CR2Cancer

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF07469 Domain of unknown function (DUF1518)
PF00010 Helix-loop-helix DNA-binding domain
PF08815 Nuclear receptor coactivator
PF00989 PAS fold
PF08832 Steroid receptor coactivator

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H3, H4	#	9296499

> Gene Ontology [ TOP ]
Biological Process	GO:0000409 regulation of transcription by galactose GO:0000411 positive regulation of transcription by galactose GO:0000429 carbon catabolite regulation of transcription from RNA polymerase II promoter GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter GO:0001101 response to acid chemical GO:0001701 in utero embryonic development GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0002154 thyroid hormone mediated signaling pathway GO:0002155 regulation of thyroid hormone mediated signaling pathway GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006820 anion transport GO:0006869 lipid transport GO:0007548 sex differentiation GO:0007584 response to nutrient GO:0007589 body fluid secretion GO:0007595 lactation GO:0007617 mating behavior GO:0007618 mating GO:0008406 gonad development GO:0008584 male gonad development GO:0009755 hormone-mediated signaling pathway GO:0009991 response to extracellular stimulus GO:0010720 positive regulation of cell development GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015721 bile acid and bile salt transport GO:0015849 organic acid transport GO:0015850 organic hydroxy compound transport GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019098 reproductive behavior GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021549 cerebellum development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0021854 hypothalamus development GO:0021987 cerebral cortex development GO:0022037 metencephalon development GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030879 mammary gland development GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0032570 response to progesterone GO:0032941 secretion by tissue GO:0035690 cellular response to drug GO:0042493 response to drug GO:0042698 ovulation cycle GO:0043401 steroid hormone mediated signaling pathway GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0044849 estrous cycle GO:0045137 development of primary sexual characteristics GO:0045666 positive regulation of neuron differentiation GO:0045924 regulation of female receptivity GO:0045925 positive regulation of female receptivity GO:0045990 carbon catabolite regulation of transcription GO:0045991 carbon catabolite activation of transcription GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0046942 carboxylic acid transport GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048732 gland development GO:0050769 positive regulation of neurogenesis GO:0050878 regulation of body fluid levels GO:0051962 positive regulation of nervous system development GO:0060179 male mating behavior GO:0060180 female mating behavior GO:0060669 embryonic placenta morphogenesis GO:0060711 labyrinthine layer development GO:0060713 labyrinthine layer morphogenesis GO:0061458 reproductive system development GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071496 cellular response to external stimulus GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901654 response to ketone GO:1904016 response to Thyroglobulin triiodothyronine GO:1904017 cellular response to Thyroglobulin triiodothyronine GO:2001023 regulation of response to drug GO:2001038 regulation of cellular response to drug
Molecular Function	GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016922 ligand-dependent nuclear receptor binding GO:0030331 estrogen receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0033142 progesterone receptor binding GO:0034212 peptide N-acetyltransferase activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042974 retinoic acid receptor binding GO:0046965 retinoid X receptor binding GO:0047485 protein N-terminus binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-194068: Bile acid and bile salt metabolism R-HSA-211859: Biological oxidations R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-1266738: Developmental Biology R-HSA-211976: Endogenous sterols R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214847: HATs acetylate histones R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-1368082: RORA activates gene expression R-HSA-159418: Recycling of bile acids and salts R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-192105: Synthesis of bile acids and bile salts R-HSA-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-1368108: BMAL1
R-HSA-194068: Bile acid and bile salt metabolism
R-HSA-211859: Biological oxidations
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-211897: Cytochrome P450 - arranged by substrate type
R-HSA-1266738: Developmental Biology
R-HSA-211976: Endogenous sterols
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214847: HATs acetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-211945: Phase 1 - Functionalization of compounds
R-HSA-1368082: RORA activates gene expression
R-HSA-159418: Recycling of bile acids and salts
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-192105: Synthesis of bile acids and bile salts
R-HSA-193807: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5889781	c.545C>T	p.P182L	Substitution - Missense	Skin
COSM1019114	c.184G>T	p.V62L	Substitution - Missense	Endometrium
COSM5396695	c.3781C>T	p.P1261S	Substitution - Missense	Skin
COSM2911481	c.3914C>T	p.T1305M	Substitution - Missense	Stomach
COSM4093215	c.2240A>G	p.Q747R	Substitution - Missense	Stomach
COSM1600258	c.2606C>A	p.P869H	Substitution - Missense	Central_nervous_system
COSM4705938	c.1391G>A	p.S464N	Substitution - Missense	Large_intestine
COSM4848224	c.959G>A	p.R320H	Substitution - Missense	Cervix
COSM3714178	c.1092C>A	p.I364I	Substitution - coding silent	Upper_aerodigestive_tract
COSM5058814	c.3320A>G	p.Q1107R	Substitution - Missense	Stomach
COSM2911451	c.3060G>A	p.T1020T	Substitution - coding silent	Biliary_tract
COSM2911447	c.2936C>T	p.T979M	Substitution - Missense	Large_intestine
COSM3839138	c.3078A>C	p.T1026T	Substitution - coding silent	Breast
COSM1306629	c.1582A>G	p.N528D	Substitution - Missense	Urinary_tract
COSM5994170	c.1670G>T	p.S557I	Substitution - Missense	Prostate
COSM321961	c.4216G>T	p.D1406Y	Substitution - Missense	Lung
COSM5968316	c.3108G>T	p.M1036I	Substitution - Missense	Genital_tract
COSM5463135	c.4093G>T	p.G1365C	Substitution - Missense	Large_intestine
COSM3910072	c.2015C>T	p.S672L	Substitution - Missense	Skin
COSM2911465	c.3625A>G	p.M1209V	Substitution - Missense	Central_nervous_system
COSM213059	c.2743G>T	p.E915*	Substitution - Nonsense	Breast
COSM5994170	c.1670G>T	p.S557I	Substitution - Missense	Prostate
COSM3798863	c.2949C>G	p.I983M	Substitution - Missense	Urinary_tract
COSM1019156	c.2692G>A	p.A898T	Substitution - Missense	Endometrium
COSM3714178	c.1092C>A	p.I364I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4486648	c.3085C>G	p.R1029G	Substitution - Missense	Skin
COSM1407038	c.65C>T	p.S22L	Substitution - Missense	Large_intestine
COSM6005840	c.4319C>A	p.T1440N	Substitution - Missense	Small_intestine
COSM213899	c.4069A>C	p.N1357H	Substitution - Missense	Breast
COSM3734184	c.1964A>C	p.K655T	Substitution - Missense	Pancreas
COSM1326285	c.2481G>A	p.L827L	Substitution - coding silent	Ovary
COSM4164465	c.230T>A	p.I77K	Substitution - Missense	Kidney
COSM2911421	c.2465A>G	p.E822G	Substitution - Missense	Large_intestine
COSM5354830	c.627C>T	p.T209T	Substitution - coding silent	Large_intestine
COSM276279	c.986G>A	p.R329K	Substitution - Missense	Large_intestine
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM3580233	c.4213G>A	p.G1405R	Substitution - Missense	Skin
COSM5505720	c.949+4A>G	p.?	Unknown	Biliary_tract
COSM1743868	c.440A>G	p.N147S	Substitution - Missense	Biliary_tract
COSM4093219	c.3404T>A	p.M1135K	Substitution - Missense	Stomach
COSM1019129	c.917A>G	p.E306G	Substitution - Missense	Endometrium
COSM418776	c.1102C>T	p.H368Y	Substitution - Missense	Urinary_tract
COSM357563	c.2899G>A	p.D967N	Substitution - Missense	Lung
COSM2911389	c.1555G>A	p.V519I	Substitution - Missense	Urinary_tract
COSM1019117	c.252A>G	p.E84E	Substitution - coding silent	Endometrium
COSM3580229	c.3098C>T	p.S1033L	Substitution - Missense	Skin
COSM3798855	c.271G>A	p.D91N	Substitution - Missense	Urinary_tract
COSM3580211	c.727C>T	p.L243L	Substitution - coding silent	Skin
COSM4505447	c.692C>T	p.S231L	Substitution - Missense	Skin
COSM5514839	c.809-10C>A	p.?	Unknown	Biliary_tract
COSM5612272	c.1486G>A	p.G496R	Substitution - Missense	Adrenal_gland
COSM2911413	c.2074C>T	p.R692W	Substitution - Missense	Large_intestine
COSM1258835	c.1538C>T	p.S513L	Substitution - Missense	Skin
COSM3933600	c.1221A>C	p.P407P	Substitution - coding silent	Urinary_tract
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM5994170	c.1670G>T	p.S557I	Substitution - Missense	Prostate
COSM3758148	c.3814C>T	p.P1272S	Substitution - Missense	Soft_tissue
COSM1019165	c.2797C>A	p.L933I	Substitution - Missense	Endometrium
COSM2911465	c.3625A>G	p.M1209V	Substitution - Missense	Central_nervous_system
COSM3773964	c.2493T>G	p.C831W	Substitution - Missense	Kidney
COSM5354061	c.117A>G	p.E39E	Substitution - coding silent	Large_intestine
COSM1722323	c.1652C>T	p.S551F	Substitution - Missense	Skin
COSM4856482	c.755G>A	p.R252Q	Substitution - Missense	Cervix
COSM4093217	c.3260G>A	p.G1087D	Substitution - Missense	Stomach
COSM4842363	c.2186C>G	p.S729C	Substitution - Missense	Cervix
COSM2911475	c.3866C>T	p.A1289V	Substitution - Missense	Large_intestine
COSM4188120	c.1987A>G	p.T663A	Substitution - Missense	Kidney
COSM4093207	c.1223C>T	p.P408L	Substitution - Missense	Stomach
COSM313154	c.1758A>G	p.K586K	Substitution - coding silent	Lung
COSM4936430	c.4326A>T	p.*1442Y	Nonstop extension	Liver
COSM1019150	c.2271G>T	p.E757D	Substitution - Missense	Endometrium
COSM2911423	c.2509G>T	p.D837Y	Substitution - Missense	Large_intestine
COSM1019138	c.1421C>A	p.S474Y	Substitution - Missense	Endometrium
COSM477204	c.321A>G	p.I107M	Substitution - Missense	Kidney
COSM461058	c.412G>C	p.E138Q	Substitution - Missense	Cervix
COSM6019283	c.1250G>A	p.R417K	Substitution - Missense	Skin
COSM4705936	c.746G>A	p.R249Q	Substitution - Missense	Large_intestine
COSM5396693	c.3556C>T	p.P1186S	Substitution - Missense	Skin
COSM5763003	c.1876T>C	p.Y626H	Substitution - Missense	Pancreas
COSM245962	c.1355A>G	p.N452S	Substitution - Missense	Prostate
COSM3933598	c.1205G>C	p.R402P	Substitution - Missense	Urinary_tract
COSM1258835	c.1538C>T	p.S513L	Substitution - Missense	Oesophagus
COSM3426320	c.197A>C	p.K66T	Substitution - Missense	Large_intestine
COSM4479866	c.2368C>T	p.P790S	Substitution - Missense	Skin
COSM3798867	c.4129C>G	p.L1377V	Substitution - Missense	Urinary_tract
COSM4093211	c.1515C>T	p.N505N	Substitution - coding silent	Stomach
COSM5058810	c.1154G>A	p.R385Q	Substitution - Missense	Stomach
COSM1195910	c.770C>T	p.T257M	Substitution - Missense	Lung
COSM5396687	c.977C>T	p.P326L	Substitution - Missense	Skin
COSM4624742	c.280G>A	p.V94I	Substitution - Missense	Large_intestine
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM4791353	c.597G>A	p.M199I	Substitution - Missense	Liver
COSM4929929	c.3271A>C	p.R1091R	Substitution - coding silent	Liver
COSM2911399	c.1815C>G	p.G605G	Substitution - coding silent	Large_intestine
COSM109318	c.3217C>T	p.R1073W	Substitution - Missense	Skin
COSM1019108	c.118A>C	p.N40H	Substitution - Missense	Endometrium
COSM3798861	c.2269G>T	p.E757*	Substitution - Nonsense	Urinary_tract
COSM1019141	c.1853G>T	p.R618I	Substitution - Missense	Endometrium
COSM3798857	c.322G>C	p.E108Q	Substitution - Missense	Urinary_tract
COSM1019135	c.1283G>A	p.S428N	Substitution - Missense	Endometrium
COSM4093197	c.968C>T	p.A323V	Substitution - Missense	Stomach
COSM4494041	c.4259C>T	p.P1420L	Substitution - Missense	Skin
COSM2911453	c.3086G>A	p.R1029Q	Substitution - Missense	Large_intestine
COSM4427455	c.2787G>A	p.E929E	Substitution - coding silent	Oesophagus
COSM1019174	c.3163C>T	p.R1055*	Substitution - Nonsense	Endometrium
COSM1019159	c.2725A>C	p.I909L	Substitution - Missense	Endometrium
COSM1019147	c.2092A>C	p.S698R	Substitution - Missense	Endometrium
COSM2911455	c.3143C>T	p.P1048L	Substitution - Missense	Large_intestine
COSM4845328	c.1715G>C	p.R572T	Substitution - Missense	Cervix
COSM1600258	c.2606C>A	p.P869H	Substitution - Missense	Central_nervous_system
COSM3839140	c.3099A>C	p.S1033S	Substitution - coding silent	Breast
COSM3991218	c.4225C>T	p.L1409L	Substitution - coding silent	Kidney
COSM1407052	c.2588C>T	p.S863F	Substitution - Missense	Large_intestine
COSM5044547	c.549G>A	p.W183*	Substitution - Nonsense	Kidney
COSM4778107	c.2702A>G	p.Q901R	Substitution - Missense	Prostate
COSM1690271	c.2668C>T	p.P890S	Substitution - Missense	Skin
COSM5396693	c.3556C>T	p.P1186S	Substitution - Missense	Skin
COSM5576244	c.3047C>T	p.P1016L	Substitution - Missense	Stomach
COSM4533855	c.2020G>A	p.G674S	Substitution - Missense	Skin
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM4905017	c.4278C>T	p.T1426T	Substitution - coding silent	Skin
COSM1306631	c.1769C>G	p.S590*	Substitution - Nonsense	Urinary_tract
COSM5581818	c.544C>T	p.P182S	Substitution - Missense	Skin
COSM313154	c.1758A>G	p.K586K	Substitution - coding silent	Soft_tissue
COSM2911411	c.2069T>G	p.L690R	Substitution - Missense	Large_intestine
COSM3580209	c.224A>T	p.D75V	Substitution - Missense	Skin
COSM4093201	c.1017C>T	p.S339S	Substitution - coding silent	Stomach
COSM4705934	c.485_486insG	p.D164fs*29	Insertion - Frameshift	Large_intestine
COSM1482976	c.4321G>A	p.E1441K	Substitution - Missense	Breast
COSM5649357	c.3672G>C	p.Q1224H	Substitution - Missense	Oesophagus
COSM1019120	c.253C>T	p.Q85*	Substitution - Nonsense	Endometrium
COSM5621355	c.3652G>A	p.G1218S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4571648	c.506T>G	p.V169G	Substitution - Missense	Skin
COSM5775100	c.4066-6T>G	p.?	Unknown	Breast
COSM3580231	c.3433C>T	p.P1145S	Substitution - Missense	Skin
COSM3673673	c.3143C>A	p.P1048Q	Substitution - Missense	Prostate
COSM3580221	c.1746C>T	p.S582S	Substitution - coding silent	Skin
COSM4093189	c.66G>A	p.S22S	Substitution - coding silent	Stomach
COSM4599760	c.3364C>T	p.R1122*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1019162	c.2736A>G	p.Q912Q	Substitution - coding silent	Endometrium
COSM5396687	c.977C>T	p.P326L	Substitution - Missense	Skin
COSM3580213	c.838C>T	p.L280L	Substitution - coding silent	Skin
COSM321959	c.2088G>T	p.E696D	Substitution - Missense	Lung
COSM4093195	c.962G>A	p.G321D	Substitution - Missense	Stomach
COSM720802	c.1054C>T	p.P352S	Substitution - Missense	Lung
COSM1614651	c.771G>A	p.T257T	Substitution - coding silent	Liver
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM183823	c.4212C>T	p.G1404G	Substitution - coding silent	Large_intestine
COSM4093223	c.3640G>C	p.G1214R	Substitution - Missense	Stomach
COSM1685867	c.3715C>T	p.P1239S	Substitution - Missense	Skin
COSM1685867	c.3715C>T	p.P1239S	Substitution - Missense	Skin
COSM3580217	c.1324G>A	p.G442R	Substitution - Missense	Skin
COSM3380114	c.3630A>C	p.T1210T	Substitution - coding silent	Pancreas
COSM1216845	c.3045A>C	p.K1015N	Substitution - Missense	Large_intestine
COSM3372721	c.3387G>A	p.Q1129Q	Substitution - coding silent	Thyroid
COSM271414	c.2754T>C	p.C918C	Substitution - coding silent	Large_intestine
COSM1614651	c.771G>A	p.T257T	Substitution - coding silent	Liver
COSM720794	c.2304G>T	p.L768L	Substitution - coding silent	Lung
COSM3734184	c.1964A>C	p.K655T	Substitution - Missense	Pancreas
COSM4093191	c.145T>A	p.L49I	Substitution - Missense	Stomach
COSM1743870	c.3181C>T	p.R1061*	Substitution - Nonsense	Biliary_tract
COSM4705940	c.3511C>A	p.P1171T	Substitution - Missense	Large_intestine
COSM3771846	c.1771A>G	p.I591V	Substitution - Missense	Pancreas
COSM4583394	c.2394A>T	p.E798D	Substitution - Missense	Bone
COSM3839136	c.2913G>C	p.E971D	Substitution - Missense	Breast
COSM3839134	c.2646A>T	p.Q882H	Substitution - Missense	Breast
COSM1216847	c.409T>G	p.S137A	Substitution - Missense	Large_intestine
COSM3580223	c.2187C>T	p.S729S	Substitution - coding silent	Skin
COSM3972165	c.3110G>A	p.G1037D	Substitution - Missense	Central_nervous_system
COSM4093225	c.3716C>T	p.P1239L	Substitution - Missense	Stomach
COSM162834	c.907C>G	p.Q303E	Substitution - Missense	Breast
COSM4776606	c.3959C>G	p.S1320C	Substitution - Missense	Breast
COSM5396697	c.4246_4247GG>AA	p.G1416K	Substitution - Missense	Skin
COSM4093221	c.3484G>A	p.G1162S	Substitution - Missense	Stomach
COSM5708152	c.1567A>G	p.S523G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM321962	c.611C>A	p.P204Q	Substitution - Missense	Lung
COSM1407046	c.1948A>G	p.I650V	Substitution - Missense	Large_intestine
COSM3758148	c.3814C>T	p.P1272S	Substitution - Missense	Large_intestine
COSM4093203	c.1064A>C	p.Q355P	Substitution - Missense	Stomach
COSM4093193	c.245G>T	p.R82I	Substitution - Missense	Stomach
COSM4140997	c.3304C>A	p.P1102T	Substitution - Missense	Ovary
COSM5695120	c.1377G>T	p.Q459H	Substitution - Missense	Soft_tissue
COSM3839142	c.3938A>G	p.N1313S	Substitution - Missense	Breast
COSM5422582	c.16G>A	p.D6N	Substitution - Missense	Prostate
COSM5889783	c.2030C>T	p.P677L	Substitution - Missense	Skin
COSM5643554	c.164G>A	p.S55N	Substitution - Missense	Oesophagus
COSM720788	c.3392G>C	p.R1131T	Substitution - Missense	Lung
COSM720782	c.4077C>G	p.P1359P	Substitution - coding silent	Lung
COSM3991214	c.1108G>A	p.G370R	Substitution - Missense	Kidney
COSM4988661	c.2983T>C	p.Y995H	Substitution - Missense	Soft_tissue
COSM1019111	c.122A>C	p.K41T	Substitution - Missense	Endometrium
COSM720790	c.2879T>C	p.L960P	Substitution - Missense	Lung
COSM3734184	c.1964A>C	p.K655T	Substitution - Missense	Pancreas
COSM5001374	c.3524C>A	p.T1175K	Substitution - Missense	Pancreas
COSM1685867	c.3715C>T	p.P1239S	Substitution - Missense	Skin
COSM78153	c.1067C>T	p.P356L	Substitution - Missense	Ovary
COSM5396691	c.3012C>T	p.L1004L	Substitution - coding silent	Skin
COSM1019153	c.2274A>C	p.K758N	Substitution - Missense	Endometrium
COSM5004002	c.103C>A	p.R35S	Substitution - Missense	Pancreas
COSM720792	c.2712A>T	p.S904S	Substitution - coding silent	Lung
COSM1019126	c.896T>G	p.F299C	Substitution - Missense	Endometrium
COSM5354061	c.117A>G	p.E39E	Substitution - coding silent	Large_intestine
COSM4406715	c.1936C>T	p.R646W	Substitution - Missense	Pancreas
COSM720784	c.4044G>T	p.M1348I	Substitution - Missense	Lung
COSM3580225	c.2245C>T	p.L749L	Substitution - coding silent	Skin
COSM1407048	c.2296C>A	p.L766M	Substitution - Missense	Large_intestine
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM4140995	c.865G>A	p.E289K	Substitution - Missense	Ovary
COSM4791353	c.597G>A	p.M199I	Substitution - Missense	Liver
COSM5823403	c.3220C>T	p.Q1074*	Substitution - Nonsense	Liver
COSM4419399	c.1512A>T	p.P504P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1019177	c.3797C>A	p.S1266Y	Substitution - Missense	Endometrium
COSM5476357	c.1924G>A	p.E642K	Substitution - Missense	Large_intestine
COSM5434309	c.180G>C	p.L60F	Substitution - Missense	Oesophagus
COSM5671725	c.594G>T	p.R198S	Substitution - Missense	Soft_tissue
COSM4566700	c.447_448GG>AA	p.E150K	Substitution - Missense	Skin
COSM4781616	c.3955G>A	p.V1319I	Substitution - Missense	Pancreas
COSM5588417	c.1750G>A	p.D584N	Substitution - Missense	Skin
COSM1216849	c.898T>G	p.F300V	Substitution - Missense	Large_intestine
COSM4570608	c.2971T>A	p.Y991N	Substitution - Missense	Skin
COSM720796	c.2298G>C	p.L766L	Substitution - coding silent	Lung
COSM5805013	c.3518A>T	p.Y1173F	Substitution - Missense	Liver
COSM384371	c.4184A>T	p.D1395V	Substitution - Missense	Lung
COSM5927241	c.3201G>A	p.Q1067Q	Substitution - coding silent	Skin
COSM5058812	c.1548C>T	p.S516S	Substitution - coding silent	Stomach
COSM1019168	c.2894G>A	p.G965E	Substitution - Missense	Endometrium
COSM5396689	c.2165C>T	p.T722I	Substitution - Missense	Skin
COSM5476357	c.1924G>A	p.E642K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1685867	c.3715C>T	p.P1239S	Substitution - Missense	Skin
COSM3580227	c.2331G>A	p.K777K	Substitution - coding silent	Skin
COSM4491131	c.3752C>T	p.P1251L	Substitution - Missense	Skin
COSM6010016	c.333C>T	p.S111S	Substitution - coding silent	Skin
COSM1019144	c.2064A>C	p.K688N	Substitution - Missense	Endometrium
COSM3580215	c.1163C>T	p.P388L	Substitution - Missense	Skin
COSM1136651	c.354+2T>C	p.?	Unknown	Kidney
COSM4093213	c.2163G>T	p.V721V	Substitution - coding silent	Stomach
COSM4133739	c.462G>C	p.T154T	Substitution - coding silent	Thyroid
COSM3939031	c.3010C>T	p.L1004F	Substitution - Missense	Oesophagus
COSM2911483	c.3954C>T	p.T1318T	Substitution - coding silent	Large_intestine
COSM3798859	c.395G>A	p.R132K	Substitution - Missense	Urinary_tract
COSM3580215	c.1163C>T	p.P388L	Substitution - Missense	Skin
COSM3839132	c.258G>C	p.E86D	Substitution - Missense	Breast
COSM574588	c.2517G>A	p.A839A	Substitution - coding silent	Large_intestine
COSM720800	c.1458C>T	p.F486F	Substitution - coding silent	Lung
COSM115931	c.391G>T	p.G131W	Substitution - Missense	Ovary
COSM1019171	c.2946G>A	p.L982L	Substitution - coding silent	Endometrium
COSM1019132	c.1018G>A	p.A340T	Substitution - Missense	Endometrium
COSM1407054	c.3987G>T	p.Q1329H	Substitution - Missense	Large_intestine
COSM4465755	c.1399C>T	p.P467S	Substitution - Missense	Skin
COSM4186810	c.3062T>C	p.M1021T	Substitution - Missense	Kidney
COSM3798865	c.3945G>C	p.M1315I	Substitution - Missense	Urinary_tract
COSM22061	c.2079_2080CT>TC	p.(=)	Unknown	Lung
COSM299362	c.1761G>T	p.E587D	Substitution - Missense	Large_intestine
COSM2911501	c.4164A>G	p.Q1388Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM5570309	c.2165C>A	p.T722N	Substitution - Missense	Prostate
COSM720798	c.1800C>G	p.N600K	Substitution - Missense	Lung
COSM5934562	c.2890G>A	p.G964S	Substitution - Missense	Skin
COSM1407050	c.2586T>C	p.T862T	Substitution - coding silent	Large_intestine
COSM1258835	c.1538C>T	p.S513L	Substitution - Missense	Central_nervous_system
COSM4093205	c.1128C>A	p.D376E	Substitution - Missense	Stomach
COSM4093209	c.1326A>C	p.G442G	Substitution - coding silent	Stomach
COSM720786	c.3751C>A	p.P1251T	Substitution - Missense	Lung
COSM5461245	c.2326G>A	p.E776K	Substitution - Missense	Large_intestine
COSM3991216	c.2058G>A	p.R686R	Substitution - coding silent	Kidney
COSM4637888	c.1811A>G	p.D604G	Substitution - Missense	Large_intestine
COSM5465510	c.1993A>G	p.N665D	Substitution - Missense	Large_intestine
COSM4093199	c.985A>G	p.R329G	Substitution - Missense	Stomach
COSM1019123	c.346C>A	p.L116I	Substitution - Missense	Endometrium
COSM4611905	c.3093delT	p.S1033fs*12	Deletion - Frameshift	Large_intestine
COSM1326283	c.4137_4138delAG	p.E1380fs*15	Deletion - Frameshift	Ovary
COSM4751402	c.384C>A	p.N128K	Substitution - Missense	Stomach
COSM5687022	c.756G>T	p.R252R	Substitution - coding silent	Soft_tissue
COSM3580219	c.1608C>T	p.I536I	Substitution - coding silent	Skin
COSM5497609	c.2693C>T	p.A898V	Substitution - Missense	Biliary_tract
COSM5625232	c.410C>G	p.S137*	Substitution - Nonsense	Oesophagus

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
26371783	mutation	Alveolar Rhabdomyosarcoma; Biphenotypic Sinonasal Sarcoma	As NCOA1 on 2p23 is a known partner in PAX3-related fusions in other tumor types (ie, alveolar rhabdomyosarcoma), we investigated its status by fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction assays in 2 BSNS cases showing only PAX3 gene rearrangements. Novel PAX3-NCOA1 fusions were identified in these 2 index cases showing an inv(2)(q35p23) by FISH and confirmed by reverse transcription polymerase chain reaction.
27283500	mutation	Thyroid Gland Follicular Carcinoma	New somatic alterations were identified in oncogenes (MDM2, FLI1), transcription factors and repressors (MITF, FLI1, ZNF331), epigenetic enzymes (KMT2A, NSD1, NCOA1, NCOA2), and protein kinases (JAK3, CHEK2, ALK).

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q15788	22	S	Phosphoserine	-	Yes	p.S22L (cancer: COAD)
Q15788	372	S	Phosphoserine	-	Yes	p.S372C (cancer: HNSC)
Q15788	395	S	Phosphoserine	-	No	None detected
Q15788	517	S	Phosphoserine	-	No	None detected
Q15788	558	S	Phosphoserine	-	No	None detected
Q15788	569	S	Phosphoserine	-	No	None detected
Q15788	698	S	Phosphoserine	-	Yes	p.S698R (cancer: UCEC)
Q15788	1033	S	Phosphoserine	-	Yes	p.S1033L (cancer: SKCM)
Q15788	1073	R	Asymmetric dimethylarginine	-	Yes	p.R1073W (cancer: READ)
Q15788	1091	R	Asymmetric dimethylarginine	-	No	None detected
Q15788	1124	R	Asymmetric dimethylarginine	-	No	None detected
Q15788	1131	R	Asymmetric dimethylarginine	-	Yes	p.R1131T (cancer: LUSC)
Q15788	1179	T	Phosphothreonine	-	No	None detected
Q15788	1185	S	Phosphoserine	-	No	None detected
Q15788	1372	S	Phosphoserine	-	No	None detected

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.318	5.767	-0.567	0.000632	NS
BRCA	Breast invasive carcinoma	112	1100	6.948	6.302	-0.618	7.89e-24	Under
CESC	Cervical and endocervical cancers	3	306	6.344	5.499	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.142	5.25	-0.961	6.69e-25	Under
ESCA	Esophageal carcinoma	11	185	7.193	6.562	-0.654	0.000497	Under
GBM	Glioblastoma multiforme	5	166	7.621	6.595	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.399	5.338	-1.031	2.01e-19	Under
KIRC	Kidney renal clear cell carcinoma	72	534	6.833	6.23	-0.62	3.71e-25	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	6.688	5.73	-0.876	2.4e-18	Under
LAML	Acute Myeloid Leukemia	0	173	NA	7.382	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.39	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.197	4.806	-0.408	1.44e-06	NS
LUAD	Lung adenocarcinoma	59	517	6.393	5.752	-0.649	1.17e-14	Under
LUSC	Lung squamous cell carcinoma	51	501	6.444	5.968	-0.469	1.25e-07	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.204	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.16	5.759	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.254	6.08	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.417	6.262	-0.179	0.0383	NS
READ	Rectum adenocarcinoma	10	167	6.349	5.343	-1.049	9.21e-08	Under
SARC	Sarcoma	2	263	5.949	5.738	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.61	5.547	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.946	6.501	-0.471	2.25e-07	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.362	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.697	5.366	-0.325	4.64e-06	NS
THYM	Thymoma	2	120	6.718	6.154	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.382	5.524	-0.81	7.98e-17	Under

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.8
Autonomic ganglia	CHP212	7.3
Autonomic ganglia	IMR32	9
Autonomic ganglia	KELLY	8
Autonomic ganglia	KPNRTBM1	8.2
Autonomic ganglia	KPNSI9S	7.9
Autonomic ganglia	KPNYN	8.2
Autonomic ganglia	MHHNB11	7.1
Autonomic ganglia	NB1	7.8
Autonomic ganglia	NH6	8.8
Autonomic ganglia	SHSY5Y	8.6
Autonomic ganglia	SIMA	7.8
Autonomic ganglia	SKNAS	7.8
Autonomic ganglia	SKNBE2	8.6
Autonomic ganglia	SKNDZ	7.9
Autonomic ganglia	SKNFI	7.8
Autonomic ganglia	SKNSH	8.3
Biliary tract	HUCCT1	6.8
Biliary tract	HUH28	7.4
Biliary tract	SNU1079	8.5
Biliary tract	SNU1196	7.1
Biliary tract	SNU245	7.4
Biliary tract	SNU308	7.8
Biliary tract	SNU478	7.7
Bone	143B	7.6
Bone	A673	9
Bone	CADOES1	8.9
Bone	CAL78	8
Bone	G292CLONEA141B1	7.6
Bone	HOS	7.3
Bone	HS706T	8
Bone	HS737T	8.4
Bone	HS819T	7.9
Bone	HS821T	8
Bone	HS822T	8.1
Bone	HS863T	7.7
Bone	HS870T	7.3
Bone	HS888T	7.6
Bone	MG63	7.6
Bone	MHHES1	9
Bone	OUMS27	7.7
Bone	RDES	7.8
Bone	SJSA1	8.1
Bone	SKES1	7.9
Bone	SKNMC	8.3
Bone	SW1353	8.7
Bone	T173	7.8
Bone	TC71	7.7
Bone	U2OS	8.4
Breast	AU565	8.3
Breast	BT20	8.7
Breast	BT474	7.8
Breast	BT483	7.8
Breast	BT549	7
Breast	CAL120	7.3
Breast	CAL148	7.9
Breast	CAL51	7.9
Breast	CAL851	7.4
Breast	CAMA1	7.1
Breast	DU4475	8.5
Breast	EFM192A	8.1
Breast	EFM19	7.6
Breast	EVSAT	7.4
Breast	HCC1143	6.5
Breast	HCC1187	8.1
Breast	HCC1395	7
Breast	HCC1419	9.3
Breast	HCC1428	9.1
Breast	HCC1500	8.3
Breast	HCC1569	8
Breast	HCC1599	7.8
Breast	HCC1806	6.9
Breast	HCC1937	7.7
Breast	HCC1954	8
Breast	HCC202	9.6
Breast	HCC2157	7.4
Breast	HCC2218	7.8
Breast	HCC38	8.5
Breast	HCC70	8.2
Breast	HDQP1	7.5
Breast	HMC18	7.9
Breast	HS274T	7.8
Breast	HS281T	7.7
Breast	HS343T	7.7
Breast	HS578T	7.6
Breast	HS606T	7.7
Breast	HS739T	7.9
Breast	HS742T	7.4
Breast	JIMT1	8.3
Breast	KPL1	8.4
Breast	MCF7	8.3
Breast	MDAMB134VI	8.4
Breast	MDAMB157	9.1
Breast	MDAMB175VII	7.8
Breast	MDAMB231	7.8
Breast	MDAMB361	8.1
Breast	MDAMB415	7.5
Breast	MDAMB436	7.3
Breast	MDAMB453	8
Breast	MDAMB468	8.9
Breast	SKBR3	8
Breast	T47D	8.2
Breast	UACC812	7.8
Breast	UACC893	5.3
Breast	YMB1	8
Breast	ZR751	7.5
Breast	ZR7530	7.7
Central nervous system	1321N1	8.1
Central nervous system	42MGBA	6.7
Central nervous system	8MGBA	7.3
Central nervous system	A172	8.2
Central nervous system	AM38	7.2
Central nervous system	BECKER	8.1
Central nervous system	CAS1	8.1
Central nervous system	CCFSTTG1	8.8
Central nervous system	D283MED	7.5
Central nervous system	D341MED	8.7
Central nervous system	DAOY	7.7
Central nervous system	DBTRG05MG	8.1
Central nervous system	DKMG	8.1
Central nervous system	GAMG	7.8
Central nervous system	GB1	8.3
Central nervous system	GI1	8.1
Central nervous system	GMS10	7.6
Central nervous system	GOS3	8.6
Central nervous system	H4	7.2
Central nervous system	HS683	8
Central nervous system	KALS1	7.6
Central nervous system	KG1C	7.8
Central nervous system	KNS42	9.5
Central nervous system	KNS60	7.7
Central nervous system	KNS81	7.5
Central nervous system	KS1	7.5
Central nervous system	LN18	8.2
Central nervous system	LN229	8
Central nervous system	M059K	7.3
Central nervous system	MOGGCCM	8
Central nervous system	MOGGUVW	6.6
Central nervous system	NMCG1	7.8
Central nervous system	ONS76	7.2
Central nervous system	SF126	7.9
Central nervous system	SF295	7.6
Central nervous system	SNB19	8.4
Central nervous system	SNU1105	7.6
Central nervous system	SNU201	8.6
Central nervous system	SNU466	7.9
Central nervous system	SNU489	8
Central nervous system	SNU626	8.4
Central nervous system	SNU738	7.3
Central nervous system	SW1088	8.8
Central nervous system	SW1783	8
Central nervous system	T98G	8.1
Central nervous system	TM31	8.5
Central nervous system	U118MG	7.9
Central nervous system	U138MG	8.2
Central nervous system	U251MG	9
Central nervous system	U87MG	7.8
Central nervous system	YH13	7.6
Central nervous system	YKG1	8.1
Endometrium	AN3CA	8
Endometrium	COLO684	8.5
Endometrium	EFE184	7.4
Endometrium	EN	7.9
Endometrium	ESS1	7.4
Endometrium	HEC108	8
Endometrium	HEC151	6.9
Endometrium	HEC1A	7.3
Endometrium	HEC1B	7.5
Endometrium	HEC251	6.7
Endometrium	HEC265	7.4
Endometrium	HEC50B	6.5
Endometrium	HEC59	5.9
Endometrium	HEC6	6.9
Endometrium	ISHIKAWAHERAKLIO02ER	8
Endometrium	JHUEM1	7.7
Endometrium	JHUEM2	8.3
Endometrium	JHUEM3	8.1
Endometrium	KLE	6.9
Endometrium	MFE280	7.8
Endometrium	MFE296	8.1
Endometrium	MFE319	7.7
Endometrium	RL952	7.6
Endometrium	SNGM	7.5
Endometrium	SNU1077	8
Endometrium	SNU685	7.7
Endometrium	TEN	6.9
Haematopoietic and lymphoid	697	8.2
Haematopoietic and lymphoid	A3KAW	8.3
Haematopoietic and lymphoid	A4FUK	7.9
Haematopoietic and lymphoid	ALLSIL	8.5
Haematopoietic and lymphoid	AML193	8.2
Haematopoietic and lymphoid	AMO1	8
Haematopoietic and lymphoid	BCP1	8.9
Haematopoietic and lymphoid	BDCM	8.7
Haematopoietic and lymphoid	BL41	7.7
Haematopoietic and lymphoid	BL70	7.3
Haematopoietic and lymphoid	BV173	6.7
Haematopoietic and lymphoid	CA46	7.6
Haematopoietic and lymphoid	CI1	8.9
Haematopoietic and lymphoid	CMK115	8.1
Haematopoietic and lymphoid	CMK86	9.3
Haematopoietic and lymphoid	CMK	9.3
Haematopoietic and lymphoid	CMLT1	8.7
Haematopoietic and lymphoid	COLO775	7.7
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	9.5
Haematopoietic and lymphoid	DEL	8.7
Haematopoietic and lymphoid	DND41	8.7
Haematopoietic and lymphoid	DOHH2	7.9
Haematopoietic and lymphoid	EB1	9.6
Haematopoietic and lymphoid	EB2	9.1
Haematopoietic and lymphoid	EHEB	9.4
Haematopoietic and lymphoid	EJM	8.7
Haematopoietic and lymphoid	EM2	7.8
Haematopoietic and lymphoid	EOL1	8
Haematopoietic and lymphoid	F36P	9.5
Haematopoietic and lymphoid	GA10	6.6
Haematopoietic and lymphoid	GDM1	8.4
Haematopoietic and lymphoid	GRANTA519	8.7
Haematopoietic and lymphoid	HDLM2	9.6
Haematopoietic and lymphoid	HDMYZ	7.2
Haematopoietic and lymphoid	HEL9217	8.9
Haematopoietic and lymphoid	HEL	9.3
Haematopoietic and lymphoid	HH	11.3
Haematopoietic and lymphoid	HL60	7.5
Haematopoietic and lymphoid	HPBALL	8.6
Haematopoietic and lymphoid	HS604T	8.2
Haematopoietic and lymphoid	HS611T	10.2
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	7.7
Haematopoietic and lymphoid	HT	7.3
Haematopoietic and lymphoid	HTK	7.4
Haematopoietic and lymphoid	HUNS1	7.9
Haematopoietic and lymphoid	HUT102	9.7
Haematopoietic and lymphoid	HUT78	8.1
Haematopoietic and lymphoid	JEKO1	8.6
Haematopoietic and lymphoid	JK1	9.3
Haematopoietic and lymphoid	JM1	8
Haematopoietic and lymphoid	JURKAT	8.4
Haematopoietic and lymphoid	JURLMK1	9.2
Haematopoietic and lymphoid	JVM2	8.9
Haematopoietic and lymphoid	JVM3	7.9
Haematopoietic and lymphoid	K562	8.7
Haematopoietic and lymphoid	KARPAS299	9.2
Haematopoietic and lymphoid	KARPAS422	8.4
Haematopoietic and lymphoid	KARPAS620	6.9
Haematopoietic and lymphoid	KASUMI1	6.4
Haematopoietic and lymphoid	KASUMI2	8
Haematopoietic and lymphoid	KASUMI6	8.8
Haematopoietic and lymphoid	KCL22	8.1
Haematopoietic and lymphoid	KE37	9.1
Haematopoietic and lymphoid	KE97	8.1
Haematopoietic and lymphoid	KG1	8.6
Haematopoietic and lymphoid	KHM1B	7.1
Haematopoietic and lymphoid	KIJK	9
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	8.4
Haematopoietic and lymphoid	KMS11	8.3
Haematopoietic and lymphoid	KMS12BM	7.6
Haematopoietic and lymphoid	KMS18	8
Haematopoietic and lymphoid	KMS20	8.3
Haematopoietic and lymphoid	KMS21BM	7.5
Haematopoietic and lymphoid	KMS26	8.5
Haematopoietic and lymphoid	KMS27	8
Haematopoietic and lymphoid	KMS28BM	7.8
Haematopoietic and lymphoid	KMS34	7.4
Haematopoietic and lymphoid	KO52	8.6
Haematopoietic and lymphoid	KOPN8	6.1
Haematopoietic and lymphoid	KU812	8.1
Haematopoietic and lymphoid	KYO1	8.5
Haematopoietic and lymphoid	L1236	9.1
Haematopoietic and lymphoid	L363	8.5
Haematopoietic and lymphoid	L428	9.2
Haematopoietic and lymphoid	L540	9.1
Haematopoietic and lymphoid	LAMA84	9
Haematopoietic and lymphoid	LOUCY	9.3
Haematopoietic and lymphoid	LP1	8.9
Haematopoietic and lymphoid	M07E	8.9
Haematopoietic and lymphoid	MC116	6.6
Haematopoietic and lymphoid	ME1	6.7
Haematopoietic and lymphoid	MEC1	7.9
Haematopoietic and lymphoid	MEC2	8.2
Haematopoietic and lymphoid	MEG01	8.3
Haematopoietic and lymphoid	MHHCALL2	8.1
Haematopoietic and lymphoid	MHHCALL3	8.7
Haematopoietic and lymphoid	MHHCALL4	8.2
Haematopoietic and lymphoid	MINO	8.8
Haematopoietic and lymphoid	MJ	9
Haematopoietic and lymphoid	MM1S	7.9
Haematopoietic and lymphoid	MOLM13	5.8
Haematopoietic and lymphoid	MOLM16	9.4
Haematopoietic and lymphoid	MOLM6	8
Haematopoietic and lymphoid	MOLP2	8.6
Haematopoietic and lymphoid	MOLP8	8.1
Haematopoietic and lymphoid	MOLT13	8.1
Haematopoietic and lymphoid	MOLT16	8.8
Haematopoietic and lymphoid	MOLT4	7.9
Haematopoietic and lymphoid	MONOMAC1	7.5
Haematopoietic and lymphoid	MONOMAC6	8.1
Haematopoietic and lymphoid	MOTN1	9.1
Haematopoietic and lymphoid	MUTZ5	8.4
Haematopoietic and lymphoid	MV411	7.5
Haematopoietic and lymphoid	NALM19	7.8
Haematopoietic and lymphoid	NALM1	8.2
Haematopoietic and lymphoid	NALM6	7.9
Haematopoietic and lymphoid	NAMALWA	8
Haematopoietic and lymphoid	NB4	7.8
Haematopoietic and lymphoid	NCIH929	7.8
Haematopoietic and lymphoid	NCO2	8.8
Haematopoietic and lymphoid	NOMO1	7.9
Haematopoietic and lymphoid	NUDHL1	6.7
Haematopoietic and lymphoid	NUDUL1	7.4
Haematopoietic and lymphoid	OCIAML2	5.7
Haematopoietic and lymphoid	OCIAML3	8
Haematopoietic and lymphoid	OCIAML5	8
Haematopoietic and lymphoid	OCILY10	7.5
Haematopoietic and lymphoid	OCILY19	8
Haematopoietic and lymphoid	OCILY3	8.6
Haematopoietic and lymphoid	OCIM1	9.2
Haematopoietic and lymphoid	OPM2	7.8
Haematopoietic and lymphoid	P12ICHIKAWA	8.8
Haematopoietic and lymphoid	P31FUJ	8.1
Haematopoietic and lymphoid	P3HR1	8.7
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	8.5
Haematopoietic and lymphoid	PF382	8.4
Haematopoietic and lymphoid	PFEIFFER	9.9
Haematopoietic and lymphoid	PL21	8.9
Haematopoietic and lymphoid	RAJI	8
Haematopoietic and lymphoid	RCHACV	7.9
Haematopoietic and lymphoid	REC1	8.9
Haematopoietic and lymphoid	REH	8
Haematopoietic and lymphoid	RI1	8.4
Haematopoietic and lymphoid	RL	6.7
Haematopoietic and lymphoid	RPMI8226	6.4
Haematopoietic and lymphoid	RPMI8402	8.4
Haematopoietic and lymphoid	RS411	7.7
Haematopoietic and lymphoid	SEM	7.1
Haematopoietic and lymphoid	SET2	9.3
Haematopoietic and lymphoid	SIGM5	7.5
Haematopoietic and lymphoid	SKM1	8.5
Haematopoietic and lymphoid	SKMM2	8.1
Haematopoietic and lymphoid	SR786	9.6
Haematopoietic and lymphoid	ST486	8.3
Haematopoietic and lymphoid	SUDHL10	5.7
Haematopoietic and lymphoid	SUDHL1	8.6
Haematopoietic and lymphoid	SUDHL4	6.9
Haematopoietic and lymphoid	SUDHL5	9.3
Haematopoietic and lymphoid	SUDHL6	8
Haematopoietic and lymphoid	SUDHL8	6.4
Haematopoietic and lymphoid	SUPB15	8.2
Haematopoietic and lymphoid	SUPHD1	8
Haematopoietic and lymphoid	SUPM2	8.2
Haematopoietic and lymphoid	SUPT11	9.3
Haematopoietic and lymphoid	SUPT1	8.7
Haematopoietic and lymphoid	TALL1	8.8
Haematopoietic and lymphoid	TF1	8.8
Haematopoietic and lymphoid	THP1	7.3
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	8
Haematopoietic and lymphoid	U266B1	9.1
Haematopoietic and lymphoid	U937	8.3
Haematopoietic and lymphoid	UT7	8.4
Haematopoietic and lymphoid	WSUDLCL2	6.6
Kidney	769P	6.8
Kidney	786O	7.4
Kidney	A498	7.9
Kidney	A704	6.8
Kidney	ACHN	7.9
Kidney	BFTC909	6.6
Kidney	CAKI1	8
Kidney	CAKI2	7.3
Kidney	CAL54	8.1
Kidney	KMRC1	7.1
Kidney	KMRC20	8
Kidney	KMRC2	6.6
Kidney	KMRC3	7.8
Kidney	OSRC2	7.9
Kidney	RCC10RGB	6.2
Kidney	SNU1272	7.6
Kidney	SNU349	8
Kidney	TUHR10TKB	7.6
Kidney	TUHR14TKB	7.1
Kidney	TUHR4TKB	7.3
Kidney	VMRCRCW	5.8
Kidney	VMRCRCZ	7.3
Large intestine	C2BBE1	8.3
Large intestine	CCK81	6.6
Large intestine	CL11	7.3
Large intestine	CL14	8
Large intestine	CL34	7.5
Large intestine	CL40	7.5
Large intestine	COLO205	6.4
Large intestine	COLO320	9.6
Large intestine	COLO678	8.3
Large intestine	CW2	6.3
Large intestine	DLD1	7.7
Large intestine	GP2D	7.2
Large intestine	HCC56	8.2
Large intestine	HCT116	7.1
Large intestine	HCT15	7.7
Large intestine	HS675T	8
Large intestine	HS698T	8.2
Large intestine	HT115	6.8
Large intestine	HT29	6.8
Large intestine	HT55	8
Large intestine	KM12	7.3
Large intestine	LOVO	7.4
Large intestine	LS1034	6.5
Large intestine	LS123	7.6
Large intestine	LS180	7.5
Large intestine	LS411N	7.1
Large intestine	LS513	6.8
Large intestine	MDST8	7.8
Large intestine	NCIH508	7.2
Large intestine	NCIH716	8.5
Large intestine	NCIH747	7.4
Large intestine	OUMS23	8.2
Large intestine	RCM1	7.5
Large intestine	RKO	6.9
Large intestine	SKCO1	7.1
Large intestine	SNU1040	7.7
Large intestine	SNU1197	6.2
Large intestine	SNU175	8.5
Large intestine	SNU283	8.3
Large intestine	SNU407	7.1
Large intestine	SNU503	9.3
Large intestine	SNU61	7.4
Large intestine	SNU81	8
Large intestine	SNUC1	5.9
Large intestine	SNUC2A	7.8
Large intestine	SNUC4	7.6
Large intestine	SNUC5	7.7
Large intestine	SW1116	7.3
Large intestine	SW1417	7.9
Large intestine	SW1463	7.6
Large intestine	SW403	8.1
Large intestine	SW480	8
Large intestine	SW48	7.7
Large intestine	SW620	8.2
Large intestine	SW837	7.5
Large intestine	SW948	8.7
Large intestine	T84	7.6
Liver	ALEXANDERCELLS	7.8
Liver	C3A	7
Liver	HEP3B217	6.3
Liver	HEPG2	7.6
Liver	HLE	7.2
Liver	HLF	7.8
Liver	HUH1	8.8
Liver	HUH6	7.6
Liver	HUH7	7.2
Liver	JHH1	7.5
Liver	JHH2	8.3
Liver	JHH4	7
Liver	JHH5	7.5
Liver	JHH6	7.8
Liver	JHH7	8.2
Liver	LI7	8.2
Liver	PLCPRF5	8.6
Liver	SKHEP1	7.6
Liver	SNU182	8.1
Liver	SNU387	8.1
Liver	SNU398	8.8
Liver	SNU423	7.6
Liver	SNU449	7.9
Liver	SNU475	8
Liver	SNU761	8.4
Liver	SNU878	8.2
Liver	SNU886	8.3
Lung	A549	7.9
Lung	ABC1	9.1
Lung	BEN	9.3
Lung	CAL12T	7.5
Lung	CALU1	7.4
Lung	CALU3	7
Lung	CALU6	8.1
Lung	CHAGOK1	9
Lung	COLO668	8.4
Lung	COLO699	8.6
Lung	CORL105	8.4
Lung	CORL23	5.8
Lung	CORL24	9.4
Lung	CORL279	8.1
Lung	CORL311	8.8
Lung	CORL47	9.1
Lung	CORL51	9.3
Lung	CORL88	8.9
Lung	CORL95	9.3
Lung	CPCN	8.4
Lung	DMS114	8.2
Lung	DMS153	8.7
Lung	DMS273	7.9
Lung	DMS454	8.4
Lung	DMS53	7.6
Lung	DMS79	7.9
Lung	DV90	7.5
Lung	EBC1	7
Lung	EPLC272H	7.1
Lung	HARA	7.8
Lung	HCC1171	7.8
Lung	HCC1195	8.5
Lung	HCC15	7.7
Lung	HCC2279	8.3
Lung	HCC2935	8.8
Lung	HCC33	8
Lung	HCC366	8.1
Lung	HCC4006	7.9
Lung	HCC44	6.3
Lung	HCC78	7.4
Lung	HCC827	7.2
Lung	HCC95	7.7
Lung	HLC1	8.5
Lung	HLFA	7.1
Lung	HS229T	7.4
Lung	HS618T	6.9
Lung	IALM	6.9
Lung	KNS62	5.4
Lung	LC1F	8.1
Lung	LC1SQSF	8.8
Lung	LCLC103H	7.5
Lung	LCLC97TM1	7.8
Lung	LK2	7.3
Lung	LOUNH91	7.7
Lung	LU65	7.3
Lung	LU99	7.5
Lung	LUDLU1	8.4
Lung	LXF289	7.2
Lung	MORCPR	7.7
Lung	NCIH1048	8.8
Lung	NCIH1092	8.5
Lung	NCIH1105	8.9
Lung	NCIH1155	9.2
Lung	NCIH1184	8.9
Lung	NCIH1299	7.8
Lung	NCIH1339	8.3
Lung	NCIH1341	8.5
Lung	NCIH1355	7.5
Lung	NCIH1373	6.9
Lung	NCIH1385	10.2
Lung	NCIH1395	8.4
Lung	NCIH1435	8
Lung	NCIH1436	8.8
Lung	NCIH1437	7.9
Lung	NCIH146	8.7
Lung	NCIH1563	8.6
Lung	NCIH1568	9.2
Lung	NCIH1573	8.4
Lung	NCIH1581	8.8
Lung	NCIH1618	9.4
Lung	NCIH1623	9.8
Lung	NCIH1648	7.9
Lung	NCIH1650	8.2
Lung	NCIH1651	7.7
Lung	NCIH1666	7.3
Lung	NCIH1693	7.7
Lung	NCIH1694	9.2
Lung	NCIH1703	8.5
Lung	NCIH1734	7.8
Lung	NCIH1755	8.2
Lung	NCIH1781	8.1
Lung	NCIH1792	7.1
Lung	NCIH1793	8.3
Lung	NCIH1836	9.5
Lung	NCIH1838	7.5
Lung	NCIH1869	7.4
Lung	NCIH1876	8.9
Lung	NCIH1915	7.6
Lung	NCIH1930	9.2
Lung	NCIH1944	7.6
Lung	NCIH1963	8.6
Lung	NCIH196	7.8
Lung	NCIH1975	7.6
Lung	NCIH2009	7.5
Lung	NCIH2023	7.9
Lung	NCIH2029	8.7
Lung	NCIH2030	7.6
Lung	NCIH2066	8.9
Lung	NCIH2081	8.6
Lung	NCIH2085	8.3
Lung	NCIH2087	7.5
Lung	NCIH209	8.6
Lung	NCIH2106	8.8
Lung	NCIH2110	8.1
Lung	NCIH211	9
Lung	NCIH2122	7.6
Lung	NCIH2126	8.5
Lung	NCIH2141	8.2
Lung	NCIH2170	8
Lung	NCIH2171	8.7
Lung	NCIH2172	7.8
Lung	NCIH2196	8.5
Lung	NCIH2227	10.1
Lung	NCIH2228	6.5
Lung	NCIH226	7.6
Lung	NCIH2286	7.8
Lung	NCIH2291	6.4
Lung	NCIH2342	9.3
Lung	NCIH2347	6.8
Lung	NCIH23	7.8
Lung	NCIH2405	7.9
Lung	NCIH2444	7.2
Lung	NCIH292	7.6
Lung	NCIH322	8.4
Lung	NCIH3255	8.2
Lung	NCIH358	6.9
Lung	NCIH441	7.4
Lung	NCIH446	8.4
Lung	NCIH460	7.4
Lung	NCIH510	8.9
Lung	NCIH520	7.5
Lung	NCIH522	8.8
Lung	NCIH524	7
Lung	NCIH526	8.2
Lung	NCIH596	8.1
Lung	NCIH647	8
Lung	NCIH650	8.3
Lung	NCIH661	8.6
Lung	NCIH69	8.3
Lung	NCIH727	7.7
Lung	NCIH810	8.5
Lung	NCIH82	7.2
Lung	NCIH838	7.4
Lung	NCIH841	8.6
Lung	NCIH854	7.9
Lung	NCIH889	8.8
Lung	PC14	7.2
Lung	RERFLCAD1	7.2
Lung	RERFLCAD2	7.6
Lung	RERFLCAI	7.3
Lung	RERFLCKJ	8.6
Lung	RERFLCMS	8.2
Lung	RERFLCSQ1	8.6
Lung	SBC5	7.9
Lung	SCLC21H	8.5
Lung	SHP77	8.2
Lung	SKLU1	7.1
Lung	SKMES1	7.5
Lung	SQ1	5.8
Lung	SW1271	8.3
Lung	SW1573	8.2
Lung	SW900	7.4
Lung	VMRCLCD	8.8
Lung	VMRCLCP	8.6
Oesophagus	COLO680N	7.2
Oesophagus	ECGI10	8.2
Oesophagus	KYSE140	7.6
Oesophagus	KYSE150	7.8
Oesophagus	KYSE180	7.7
Oesophagus	KYSE270	7.5
Oesophagus	KYSE30	8.4
Oesophagus	KYSE410	7.9
Oesophagus	KYSE450	8.5
Oesophagus	KYSE510	7.1
Oesophagus	KYSE520	7.9
Oesophagus	KYSE70	8.7
Oesophagus	OE19	7.4
Oesophagus	OE33	7.4
Oesophagus	TE10	8
Oesophagus	TE11	6.6
Oesophagus	TE14	8.6
Oesophagus	TE15	7
Oesophagus	TE1	8.8
Oesophagus	TE4	8
Oesophagus	TE5	8.7
Oesophagus	TE6	7.8
Oesophagus	TE8	7.6
Oesophagus	TE9	7.9
Oesophagus	TT	8.2
Ovary	59M	7.7
Ovary	A2780	7.6
Ovary	CAOV3	8
Ovary	CAOV4	8.1
Ovary	COLO704	8
Ovary	COV318	8.5
Ovary	COV362	5.9
Ovary	COV434	8
Ovary	COV504	7.7
Ovary	COV644	7.8
Ovary	EFO21	6.8
Ovary	EFO27	7.8
Ovary	ES2	6.8
Ovary	FUOV1	7
Ovary	HEYA8	6.6
Ovary	HS571T	8.1
Ovary	IGROV1	6.4
Ovary	JHOC5	7.4
Ovary	JHOM1	8.3
Ovary	JHOM2B	8.1
Ovary	JHOS2	8.2
Ovary	JHOS4	8
Ovary	KURAMOCHI	6.4
Ovary	MCAS	7
Ovary	NIHOVCAR3	8
Ovary	OAW28	8
Ovary	OAW42	8.1
Ovary	OC314	7.1
Ovary	OC316	7.1
Ovary	ONCODG1	8.4
Ovary	OV56	7.2
Ovary	OV7	6.7
Ovary	OV90	9
Ovary	OVCAR4	8.3
Ovary	OVCAR8	6.4
Ovary	OVISE	7.1
Ovary	OVK18	7.9
Ovary	OVKATE	6.8
Ovary	OVMANA	7.6
Ovary	OVSAHO	7.2
Ovary	OVTOKO	7.6
Ovary	RMGI	7.3
Ovary	RMUGS	8.6
Ovary	SKOV3	8.2
Ovary	SNU119	7.6
Ovary	SNU840	9
Ovary	SNU8	7.2
Ovary	TOV112D	8.4
Ovary	TOV21G	7.7
Ovary	TYKNU	7.4
Pancreas	ASPC1	8.5
Pancreas	BXPC3	6.2
Pancreas	CAPAN1	7.8
Pancreas	CAPAN2	7.1
Pancreas	CFPAC1	7.1
Pancreas	DANG	7.6
Pancreas	HPAC	7.7
Pancreas	HPAFII	7
Pancreas	HS766T	7.4
Pancreas	HUPT3	7.1
Pancreas	HUPT4	7.2
Pancreas	KCIMOH1	7.7
Pancreas	KLM1	7.6
Pancreas	KP2	8.1
Pancreas	KP3	8
Pancreas	KP4	8.1
Pancreas	L33	7.7
Pancreas	MIAPACA2	7.4
Pancreas	PANC0203	7.1
Pancreas	PANC0213	7.8
Pancreas	PANC0327	7
Pancreas	PANC0403	7.1
Pancreas	PANC0504	8
Pancreas	PANC0813	7.5
Pancreas	PANC1005	7.6
Pancreas	PANC1	8.3
Pancreas	PATU8902	7.3
Pancreas	PATU8988S	8.6
Pancreas	PATU8988T	7.9
Pancreas	PK1	7.8
Pancreas	PK45H	7.1
Pancreas	PK59	7.2
Pancreas	PL45	7.7
Pancreas	PSN1	7.8
Pancreas	QGP1	8.4
Pancreas	SNU213	7
Pancreas	SNU324	8
Pancreas	SNU410	8.2
Pancreas	SU8686	8.3
Pancreas	SUIT2	8.1
Pancreas	SW1990	7.2
Pancreas	T3M4	6.1
Pancreas	TCCPAN2	7.9
Pancreas	YAPC	7.9
Pleura	ACCMESO1	7.2
Pleura	DM3	7.8
Pleura	ISTMES1	7.1
Pleura	ISTMES2	7.9
Pleura	JL1	7.9
Pleura	MPP89	7.8
Pleura	MSTO211H	7.4
Pleura	NCIH2052	8.6
Pleura	NCIH2452	7.9
Pleura	NCIH28	7.4
Prostate	22RV1	7.1
Prostate	DU145	7.3
Prostate	LNCAPCLONEFGC	8
Prostate	MDAPCA2B	10.7
Prostate	NCIH660	8.3
Prostate	PC3	7.1
Prostate	VCAP	7.9
Salivary gland	A253	7.8
Salivary gland	YD15	7
Skin	A101D	8
Skin	A2058	7.6
Skin	A375	7.2
Skin	C32	7.8
Skin	CHL1	8.2
Skin	CJM	7.3
Skin	COLO679	7.8
Skin	COLO741	7.5
Skin	COLO783	7.9
Skin	COLO792	6.7
Skin	COLO800	8.1
Skin	COLO818	7.7
Skin	COLO829	7.9
Skin	COLO849	7.7
Skin	G361	6.6
Skin	GRM	7
Skin	HMCB	8.1
Skin	HS294T	7.7
Skin	HS600T	7.8
Skin	HS688AT	8
Skin	HS695T	7.9
Skin	HS839T	7.8
Skin	HS852T	8.1
Skin	HS895T	7.2
Skin	HS934T	7.5
Skin	HS936T	8.2
Skin	HS939T	8
Skin	HS940T	7.9
Skin	HS944T	7.7
Skin	HT144	7.5
Skin	IGR1	7.9
Skin	IGR37	7.8
Skin	IGR39	7.6
Skin	IPC298	7
Skin	K029AX	7.9
Skin	LOXIMVI	8
Skin	MALME3M	7.8
Skin	MDAMB435S	7.8
Skin	MELHO	7.6
Skin	MELJUSO	7.4
Skin	MEWO	7.9
Skin	RPMI7951	8
Skin	RVH421	7.7
Skin	SH4	8.1
Skin	SKMEL1	8
Skin	SKMEL24	8
Skin	SKMEL28	8
Skin	SKMEL2	7.2
Skin	SKMEL30	7.5
Skin	SKMEL31	8
Skin	SKMEL3	7.8
Skin	SKMEL5	8.1
Skin	UACC257	7.4
Skin	UACC62	7.7
Skin	WM115	7.7
Skin	WM1799	7.5
Skin	WM2664	8.2
Skin	WM793	8
Skin	WM88	7.6
Skin	WM983B	7.5
Small intestine	HUTU80	8.4
Soft tissue	A204	7.6
Soft tissue	G401	7.9
Soft tissue	G402	8
Soft tissue	GCT	7.7
Soft tissue	HS729	7.3
Soft tissue	HT1080	7.5
Soft tissue	KYM1	7.4
Soft tissue	MESSA	7.9
Soft tissue	RD	9.9
Soft tissue	RH30	9.7
Soft tissue	RH41	11
Soft tissue	RKN	7
Soft tissue	S117	8.1
Soft tissue	SJRH30	10.7
Soft tissue	SKLMS1	7.9
Soft tissue	SKUT1	7.9
Soft tissue	TE125T	7.7
Soft tissue	TE159T	7.9
Soft tissue	TE441T	8.6
Soft tissue	TE617T	8.7
Stomach	2313287	7.7
Stomach	AGS	8.3
Stomach	AZ521	7.9
Stomach	ECC10	9
Stomach	ECC12	9.1
Stomach	FU97	7.8
Stomach	GCIY	7.7
Stomach	GSS	8.2
Stomach	GSU	6
Stomach	HGC27	7.5
Stomach	HS746T	8.6
Stomach	HUG1N	8.2
Stomach	IM95	7.4
Stomach	KATOIII	7.8
Stomach	KE39	8.1
Stomach	LMSU	7.9
Stomach	MKN1	7.1
Stomach	MKN45	6.6
Stomach	MKN74	8.8
Stomach	MKN7	8
Stomach	NCCSTCK140	8.8
Stomach	NCIN87	8.7
Stomach	NUGC2	7.6
Stomach	NUGC3	7.3
Stomach	NUGC4	7.5
Stomach	OCUM1	6.7
Stomach	RERFGC1B	8.9
Stomach	SH10TC	7.6
Stomach	SNU16	6.9
Stomach	SNU1	8.4
Stomach	SNU216	7.7
Stomach	SNU520	7
Stomach	SNU5	8.1
Stomach	SNU601	8.4
Stomach	SNU620	7.9
Stomach	SNU668	9
Stomach	SNU719	8.7
Stomach	TGBC11TKB	8
Thyroid	8305C	7.2
Thyroid	8505C	6.9
Thyroid	BCPAP	7.5
Thyroid	BHT101	7.1
Thyroid	CAL62	7.3
Thyroid	CGTHW1	7.2
Thyroid	FTC133	7.3
Thyroid	FTC238	7.1
Thyroid	ML1	7.4
Thyroid	SW579	7.9
Thyroid	TT2609C02	8.1
Thyroid	TT	9.2
Upper aerodigestive tract	BHY	6.7
Upper aerodigestive tract	BICR16	6.5
Upper aerodigestive tract	BICR18	7.5
Upper aerodigestive tract	BICR22	7.4
Upper aerodigestive tract	BICR31	7.8
Upper aerodigestive tract	BICR56	7.2
Upper aerodigestive tract	BICR6	7.9
Upper aerodigestive tract	CAL27	7.5
Upper aerodigestive tract	CAL33	7.1
Upper aerodigestive tract	DETROIT562	6.3
Upper aerodigestive tract	FADU	7.9
Upper aerodigestive tract	HS840T	7.6
Upper aerodigestive tract	HSC2	7.2
Upper aerodigestive tract	HSC3	6.8
Upper aerodigestive tract	HSC4	8.6
Upper aerodigestive tract	PECAPJ15	8.1
Upper aerodigestive tract	PECAPJ34CLONEC12	7
Upper aerodigestive tract	PECAPJ41CLONED2	7.4
Upper aerodigestive tract	PECAPJ49	7.9
Upper aerodigestive tract	SCC15	6.9
Upper aerodigestive tract	SCC25	6.3
Upper aerodigestive tract	SCC4	6.3
Upper aerodigestive tract	SCC9	7.5
Upper aerodigestive tract	SNU1076	7.6
Upper aerodigestive tract	SNU1214	6.4
Upper aerodigestive tract	SNU46	7.9
Upper aerodigestive tract	SNU899	7.1
Upper aerodigestive tract	YD10B	7.4
Upper aerodigestive tract	YD38	6.3
Upper aerodigestive tract	YD8	8.2
Urinary tract	5637	5.8
Urinary tract	639V	8.8
Urinary tract	647V	7.7
Urinary tract	BC3C	7
Urinary tract	BFTC905	6.7
Urinary tract	CAL29	7.9
Urinary tract	HS172T	7.7
Urinary tract	HT1197	8.5
Urinary tract	HT1376	7.7
Urinary tract	J82	7.2
Urinary tract	JMSU1	7.5
Urinary tract	KMBC2	8.4
Urinary tract	KU1919	7.4
Urinary tract	RT11284	8.2
Urinary tract	RT112	7.8
Urinary tract	RT4	8.3
Urinary tract	SCABER	6.6
Urinary tract	SW1710	7.4
Urinary tract	SW780	8.5
Urinary tract	T24	7.3
Urinary tract	TCCSUP	7.6
Urinary tract	UMUC1	7.6
Urinary tract	UMUC3	7.5
Urinary tract	VMCUB1	7.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	19.1
Adrenal gland	19
Appendix	18.5
Bone marrow	11.1
Breast	21.2
Cerebral cortex	42.3
Cervix, uterine	28.7
Colon	13.4
Duodenum	21.6
Endometrium	31
Epididymis	15.3
Esophagus	19.6
Fallopian tube	25.9
Gallbladder	22.1
Heart muscle	10.9
Kidney	20.4
Liver	7.8
Lung	23.8
Lymph node	18
Ovary	32.6
Pancreas	3.6
Parathyroid gland	58
Placenta	24.4
Prostate	24.7
Rectum	18.5
Salivary gland	6.8
Seminal vesicle	27.8
Skeletal muscle	9.3
Skin	17.9
Small intestine	21.2
Smooth muscle	27.6
Spleen	22.8
Stomach	11.3
Testis	36.8
Thyroid gland	19.7
Tonsil	15.5
Urinary bladder	15.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
24282087	overexpression	Osteosarcoma	In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues.
24304549	overexpression	Breast Carcinoma	As the members of the p160/nuclear receptor co-activator (NCOA) family, NCOA1, NCOA2 and NCOA3 are known to be overexpressed in breast cancer and essentially involved in estrogen-mediated cancer cell proliferation we asked if these proteins are involved in the ERα-mediated transactivation of PLAC1 in breast cancer cells.
26082485	overexpression	Hepatocellular Carcinoma	In this study, we report that SRC-1 was overexpressed in 25 (62.5%) of 40 human hepatocellular carcinoma (HCC) specimens.
27255895	overexpression	Prostate Carcinoma	Immunohistochemical staining of PCa patient samples revealed a strong increase in NCOA1 expression in primary tumors compared with normal prostate tissue, while no final conclusion could be drawn for PRKD1 expression in tumor specimens.
26516695	aberrant expression	Head and Neck Squamous Cell Carcinoma	CKMT1 and NCOA1 were identified as independent risk factors for survival in an independent cohort analyzed by immunohistochemistry.
26287601	overexpression	Breast Carcinoma	Nuclear receptor coactivator 1 (NCOA1) is overexpressed in a subset of breast cancer and its increased expression positively correlates with disease recurrence and metastasis.
25534237	underexpression	Meningothelial Cell Neoplasm; Neuroepithelial Neoplasm	Compared to normal brain tissue, we found that the expression of SRC-1, SRC-3, and ER-α significantly decreased in meningothelial tumor and neuroepithelial tumor, suggesting that the SRC-1/SRC-3 levels may be regulated by ER-α.
24705462	overexpression	Breast Carcinoma; Endometrial Carcinoma; Prostate Carcinoma	The steroid receptor coactivator-1 (SRC-1) is highly expressed in breast, endometrial, and prostate cancer.
23531850	aberrant expression	Adrenal Cortex Carcinoma	Positive staining was observed for SRC-1 (39/40; 97.5%), inhibin-α (37/40; 92.5%), calretinin (32/40; 80%), synaptophysin (29/40; 72.5%), melan A (26/40; 65%), and CAM5.2 (9/40; 22.5%).
21654685	overexpression	Melanoma	Expression levels of the transcription factor HOXC11 and its coactivator SRC-1 were significantly elevated in malignant melanoma in comparison with benign nevi (P<0.001 and P=0.017, respectively, n=80), and expression of HOXC11 and SRC-1 in the malignant tissue associated with each other (P<0.001).
21343398	overexpression	Breast Carcinoma	Steroid receptor coactivator-1 (SRC-1 or NCOA1) is overexpressed in a subset of breast cancers with poor prognosis.
20032008	aberrant expression	Anaplastic Thyroid Tumor	Totally, 87% of anaplastic tumours were positive for SRC-1.
28521442	Underexpression	Gastric Carcinoma	Significantly decreased levels of STS, HSD3B1, ESR2, AR, NCOA1 and NCOR1 mRNA, in addition to significantly increased levels of CYP19A1 mRNA were demonstrated in tumoral tissue samples compared with adjacent healthy gastric tissue samples.
28222670	Overexpression	Bladder Carcinoma	Here, we show that significantly higher levels of nuclear receptor coactivator 1 and significantly lower levels of miR-223-3p were detected in bladder carcinoma tissue, compared to the adjacent non-tumor tissue.
28060733	Overexpression	Hepatocellular Carcinoma	Furthermore, concomitant high expression of NCOA1 and low expression of miR-105-1 correlated with a shorter median OS and PFS in HCC patients.

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.478	1.79e-24	7.4	57.9	34.7	Gain
BRCA	Breast invasive carcinoma	1075	0.158	2.07e-07	17.5	67.6	14.9	Neutral
CESC	Cervical and endocervical cancers	292	0.436	5.9e-15	4.5	68.8	26.7	Neutral
COAD	Colon adenocarcinoma	449	0.232	6.52e-07	1.8	79.1	19.2	Neutral
ESCA	Esophageal carcinoma	183	0.202	0.00598	9.8	53	37.2	Gain
GBM	Glioblastoma multiforme	147	0.316	9.92e-05	6.8	85.7	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.362	2.09e-17	6.8	73.3	19.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.18	3.19e-05	2.7	83	14.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.23	8.19e-05	2.4	82.3	15.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.028	0.716	0.6	98.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.143	0.00113	5.3	91.6	3.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.397	3.7e-15	8.5	76.1	15.4	Neutral
LUAD	Lung adenocarcinoma	512	0.295	9.07e-12	6.4	64.3	29.3	Neutral
LUSC	Lung squamous cell carcinoma	498	0.472	4.87e-29	3.6	47	49.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.483	6.24e-19	17.3	41.7	41	Gain
PAAD	Pancreatic adenocarcinoma	177	0.233	0.00178	10.7	81.9	7.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.415	4.11e-08	5.6	90.1	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.12	0.00774	4.1	91.9	4.1	Neutral
READ	Rectum adenocarcinoma	164	0.208	0.00749	7.3	69.5	23.2	Neutral
SARC	Sarcoma	255	0.424	1.55e-12	35.7	51.8	12.5	Loss
SKCM	Skin Cutaneous Melanoma	367	0.305	2.33e-09	16.3	65.7	18	Neutral
STAD	Stomach adenocarcinoma	413	0.302	3.68e-10	7.5	72.6	19.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.153	0.0612	2	56.7	41.3	Gain
THCA	Thyroid carcinoma	497	0	0.994	2	97.6	0.4	Neutral
THYM	Thymoma	119	-0.199	0.0299	1.7	97.5	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.289	8.94e-12	3	75.6	21.4	Neutral

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.021	0.659	17	408	0.007	0.356	NS/NA
BRCA	Breast invasive carcinoma	-0.126	0.000191	83	785	0.072	0.165	NS/NA
CESC	Cervical and endocervical cancers	-0.153	0.00726	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.046	0.418	19	297	0.026	1.97e-05	NS/NA
ESCA	Esophageal carcinoma	-0.175	0.015	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.039	0.758	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.134	0.00182	20	522	0.22	1.67e-06	Increased
KIRC	Kidney renal clear cell carcinoma	-0.154	0.00418	24	319	-0.004	0.00653	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.144	0.0131	23	275	0.117	1.46e-16	NS/NA
LAML	Acute Myeloid Leukemia	0.22	0.00402	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.04	0.361	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	0.098	0.0463	41	373	-0.01	5.67e-12	NS/NA
LUAD	Lung adenocarcinoma	-0.237	1.85e-07	21	456	0.181	2.55e-10	NS/NA
LUSC	Lung squamous cell carcinoma	-0.065	0.208	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	0.3	0.437	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.153	0.0389	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0.168	0.0216	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.081	0.0627	35	498	-0.065	0.0257	NS/NA
READ	Rectum adenocarcinoma	0.188	0.0598	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.051	0.406	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	0.165	0.000315	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.045	0.386	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.499	3.02e-11	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	0.027	0.523	50	509	0.007	0.00616	NS/NA
THYM	Thymoma	-0.167	0.0661	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.155	0.000783	34	431	0.044	0.942	NS/NA

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	2	Medium
Breast	3	High
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	3	High
Kidney	3	High
Liver	1	Low
Lung	2	Medium
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	1	Low
Spleen	1	Low
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.399	NS	24476821
BRCA	Breast invasive carcinoma	521	6.5e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	0.583	NS	22810696
GBM	Glioblastoma multiforme	157	0.0504	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.2e-11	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0746	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00119	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000366	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000658	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.587	NS	21720365
PRAD	Prostate adenocarcinoma	333	1.23e-06	Significant	26544944
READ	Rectum adenocarcinoma	67	0.507	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.81	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000119	Significant	25079317
THCA	Thyroid carcinoma	391	9.24e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.118	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.019	0.936	NS
BRCA	Breast invasive carcinoma	1079	1.107	0.651	NS
CESC	Cervical and endocervical cancers	291	0.944	0.86	NS
COAD	Colon adenocarcinoma	439	0.694	0.244	NS
ESCA	Esophageal carcinoma	184	1.179	0.634	NS
GBM	Glioblastoma multiforme	158	0.757	0.292	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.731	0.103	NS
KIRC	Kidney renal clear cell carcinoma	531	0.383	1.24e-05	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.01	0.98	NS
LAML	Acute Myeloid Leukemia	149	0.759	0.33	NS
LGG	Brain Lower Grade Glioma	511	0.668	0.0846	NS
LIHC	Liver hepatocellular carcinoma	365	1.094	0.706	NS
LUAD	Lung adenocarcinoma	502	0.986	0.945	NS
LUSC	Lung squamous cell carcinoma	494	1.022	0.909	NS
OV	Ovarian serous cystadenocarcinoma	303	1.185	0.424	NS
PAAD	Pancreatic adenocarcinoma	177	0.619	0.104	NS
PCPG	Pheochromocytoma and Paraganglioma	179	609697515.212	0.311	NS
PRAD	Prostate adenocarcinoma	497	0.301	0.257	NS
READ	Rectum adenocarcinoma	159	1.557	0.466	NS
SARC	Sarcoma	259	0.877	0.646	NS
SKCM	Skin Cutaneous Melanoma	459	0.654	0.0276	Longer
STAD	Stomach adenocarcinoma	388	1.364	0.16	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.342	NS
THCA	Thyroid carcinoma	500	1.629	0.556	NS
THYM	Thymoma	119	0.724	0.701	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.706	0.0583	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.119	0.0161	Higher
BRCA	Breast invasive carcinoma	1071	-0.03	0.321	NS
CESC	Cervical and endocervical cancers	167	-0.105	0.178	NS
COAD	Colon adenocarcinoma	445	0.01	0.833	NS
ESCA	Esophageal carcinoma	162	-0.021	0.791	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.052	0.27	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.207	1.54e-06	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.002	0.97	NS
LIHC	Liver hepatocellular carcinoma	347	0.051	0.348	NS
LUAD	Lung adenocarcinoma	507	-0.001	0.982	NS
LUSC	Lung squamous cell carcinoma	497	0.04	0.378	NS
OV	Ovarian serous cystadenocarcinoma	302	0.033	0.573	NS
PAAD	Pancreatic adenocarcinoma	176	-0.043	0.574	NS
READ	Rectum adenocarcinoma	156	0.095	0.24	NS
SKCM	Skin Cutaneous Melanoma	410	0.007	0.895	NS
STAD	Stomach adenocarcinoma	392	0.034	0.504	NS
TGCT	Testicular Germ Cell Tumors	81	-0.3	0.00644	Lower
THCA	Thyroid carcinoma	499	-0.056	0.208	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.038	0.393	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.065	0.288	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.062	0.165	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.202	3.2e-06	Lower
LGG	Brain Lower Grade Glioma	514	-0.196	8e-06	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.084	0.11	NS
OV	Ovarian serous cystadenocarcinoma	296	0.014	0.805	NS
PAAD	Pancreatic adenocarcinoma	176	-0.138	0.0682	NS
STAD	Stomach adenocarcinoma	406	0.085	0.0865	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.049	0.257	NS

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

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DrugBank ID	Name	Type
DB01645	Genistein	Small Molecule Drug
DB04652	(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE	Small Molecule Drug
DB06832	2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL	Small Molecule Drug
DB06875	3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE	Small Molecule Drug
DB06908	(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID	Small Molecule Drug
DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	Small Molecule Drug
DB07009	2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL	Small Molecule Drug
DB07080	N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE	Small Molecule Drug
DB07119	1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL	Small Molecule Drug
DB07150	4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME	Small Molecule Drug
DB07198	5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE	Small Molecule Drug
DB07215	2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID	Small Molecule Drug
DB07230	3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE	Small Molecule Drug
DB07236	3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL	Small Molecule Drug
DB07530	(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol	Small Molecule Drug
DB07557	(5BETA)-PREGNANE-3,20-DIONE	Small Molecule Drug
DB07724	3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid	Small Molecule Drug
DB08220	(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid	Small Molecule Drug
DB08231	MYRISTIC ACID	Small Molecule Drug
DB08742	1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)	Small Molecule Drug
DB08915	Aleglitazar	Small Molecule Drug

Summary
Symbol	NCOA1
Name	nuclear receptor coactivator 1
Aliases	F-SRC-1; NCoA-1; KAT13A; RIP160; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; class E basic helix-loop ......
Location	2p23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26082485	Hepatocellular Carcinoma	downstream	PCNA; c-Myc	positive regulation	Knockdown of SRC-1 reduced protein levels of the proliferation marker proliferating cell nuclear antigen (PCNA) and the oncogene c-Myc.
27255895	Prostate Carcinoma	downstream	PRKD1	negative regulation	Protein kinase D1 (PRKD1) was found to be prominently up-regulated by NCOA1 knockdown in MDA PCa 2b, but not in PC3 cells.
26371783	Alveolar Rhabdomyosarcoma; Biphenotypic Sinonasal Sarcoma	partner	PAX3	Fusion	As NCOA1 on 2p23 is a known partner in PAX3-related fusions in other tumor types (ie, alveolar rhabdomyosarcoma), we investigated its status by fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction assays in 2 BSNS cases showing only PAX3 gene rearrangements. Novel PAX3-NCOA1 fusions were identified in these 2 index cases showing an inv(2)(q35p23) by FISH and confirmed by reverse transcription polymerase chain reaction.
26287601	Breast Carcinoma	downstream	TWIST1; ITGA5; CSF-1; SDF1; CXCR4; VEGFa	positive regulation	Although NCOA1 is known to promote breast cancer metastasis through working with multiple transcription factors to upregulate the expression of Twist1, ITGA5, CSF-1, SDF1 and CXCR4, the role of NCOA1 in breast tumor angiogenesis has not been investigated. At the molecular level, NCOA1 upregulates VEGFa expression in both mouse mammary tumors and cultured breast cancer cells, and it does so by associating with both c-Fos, which is recruited to the AP-1 site at bp -938 of the VEGFa promoter, and HIF1α, which is recruited to the HIF1α-binding element at bp -979 of the VEGFa promoter, to enhance VEGFa transcription.
20032008	Anaplastic Thyroid Tumor	partner	NcoR	correlation	These data suggest opposing roles for the coregulators SRC-1 and NCoR in thyroid tumour progression.
28222670	Bladder Carcinoma	upstream	miR-233-3p	Negative regulation	In vitro, depletion of miR-223-3p increased bladder carcinoma cell invasion, which was abolished by overexpression of nuclear receptor coactivator 1. Bioinformatics studies demonstrate that miR-223-3p may bind to the 3'-UTR of nuclear receptor coactivator 1 messenger RNA to inhibit its protein translation in bladder carcinoma cells.
28060733	Hepatocellular Carcinoma	upstream	miR-105-1	Negative regulation	Furthermore, concomitant high expression of NCOA1 and low expression of miR-105-1 correlated with a shorter median OS and PFS in HCC patients. In conclusion, our results provide the first evidence that NCOA1 is a direct target of miR-105-1 suggesting that NCOA1 and miR-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC patients.