CR2Cancer

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF13820 Putative nucleic acid-binding region

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor	Histone methylation	#	#	17500065

> Gene Ontology [ TOP ]
Biological Process	GO:0006260 DNA replication GO:0006310 DNA recombination GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007507 heart development GO:0009755 hormone-mediated signaling pathway GO:0030099 myeloid cell differentiation GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031958 corticosteroid receptor signaling pathway GO:0042921 glucocorticoid receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0048545 response to steroid hormone GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound
Molecular Function	GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0030331 estrogen receptor binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042974 retinoic acid receptor binding GO:0046965 retinoid X receptor binding GO:0046966 thyroid hormone receptor binding GO:0051427 hormone receptor binding
Cellular Component	GO:0005667 transcription factor complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-1368082: RORA activates gene expression R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-1368108: BMAL1
R-HSA-400253: Circadian Clock
R-HSA-1266738: Developmental Biology
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-1368082: RORA activates gene expression
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM5638373	c.3423A>G	p.P1141P	Substitution - coding silent	Oesophagus
COSM1026091	c.2730C>T	p.N910N	Substitution - coding silent	Large_intestine
COSM1307309	c.258G>A	p.Q86Q	Substitution - coding silent	Urinary_tract
COSM272997	c.6007C>T	p.P2003S	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Pancreas
COSM1632251	c.3920C>T	p.S1307F	Substitution - Missense	Liver
COSM3840815	c.6103C>T	p.R2035C	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM2758189	c.2431G>A	p.D811N	Substitution - Missense	Small_intestine
COSM5639021	c.637C>G	p.Q213E	Substitution - Missense	Oesophagus
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM1483562	c.256C>T	p.Q86*	Substitution - Nonsense	Breast
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM5028681	c.3198G>T	p.Q1066H	Substitution - Missense	Breast
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM1190243	c.3134C>T	p.S1045L	Substitution - Missense	Lung
COSM3707718	c.4778C>T	p.P1593L	Substitution - Missense	Liver
COSM723975	c.4215G>T	p.V1405V	Substitution - coding silent	Lung
COSM3545554	c.4685C>T	p.P1562L	Substitution - Missense	Skin
COSM262333	c.5126C>A	p.S1709Y	Substitution - Missense	Large_intestine
COSM723969	c.1900C>A	p.Q634K	Substitution - Missense	Lung
COSM4971404	c.1362A>T	p.G454G	Substitution - coding silent	Central_nervous_system
COSM3363195	c.491G>A	p.G164E	Substitution - Missense	Kidney
COSM4581745	c.2643G>A	p.T881T	Substitution - coding silent	Bone
COSM3740094	c.2179C>T	p.Q727*	Substitution - Nonsense	Liver
COSM5775121	c.5968G>A	p.E1990K	Substitution - Missense	Breast
COSM4616534	c.4794T>C	p.T1598T	Substitution - coding silent	Large_intestine
COSM4097806	c.3247C>T	p.Q1083*	Substitution - Nonsense	Skin
COSM1411314	c.3513G>A	p.S1171S	Substitution - coding silent	Large_intestine
COSM1307306	c.582G>A	p.M194I	Substitution - Missense	Urinary_tract
COSM3545562	c.2962C>T	p.P988S	Substitution - Missense	Skin
COSM4440804	c.961C>A	p.L321M	Substitution - Missense	Large_intestine
COSM1172714	c.3194C>T	p.S1065F	Substitution - Missense	Skin
COSM4581743	c.5385C>G	p.P1795P	Substitution - coding silent	Bone
COSM1732436	c.2881C>T	p.P961S	Substitution - Missense	Bone
COSM1196590	c.5515C>T	p.L1839F	Substitution - Missense	Skin
COSM1026100	c.1604C>T	p.S535L	Substitution - Missense	Skin
COSM6004375	c.5490G>T	p.K1830N	Substitution - Missense	Prostate
COSM3840822	c.236-2A>T	p.?	Unknown	Breast
COSM4771824	c.129G>A	p.L43L	Substitution - coding silent	Stomach
COSM3545549	c.5896C>T	p.P1966S	Substitution - Missense	Skin
COSM5564644	c.4954C>T	p.R1652W	Substitution - Missense	Prostate
COSM443686	c.4115G>C	p.R1372T	Substitution - Missense	Breast
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Endometrium
COSM3545560	c.3234C>T	p.V1078V	Substitution - coding silent	Skin
COSM6004375	c.5490G>T	p.K1830N	Substitution - Missense	Prostate
COSM2758212	c.1464C>T	p.N488N	Substitution - coding silent	Upper_aerodigestive_tract
COSM5914302	c.3563C>T	p.S1188F	Substitution - Missense	Skin
COSM387248	c.49T>A	p.C17S	Substitution - Missense	Lung
COSM5009881	c.2505C>G	p.A835A	Substitution - coding silent	Large_intestine
COSM1026069	c.4469C>T	p.S1490L	Substitution - Missense	Endometrium
COSM4705971	c.3980G>T	p.S1327I	Substitution - Missense	Large_intestine
COSM4291451	c.831A>G	p.Q277Q	Substitution - coding silent	Large_intestine
COSM5974004	c.504A>C	p.A168A	Substitution - coding silent	Upper_aerodigestive_tract
COSM3545571	c.240C>T	p.S80S	Substitution - coding silent	Skin
COSM1632252	c.652G>T	p.D218Y	Substitution - Missense	Liver
COSM3545556	c.4436T>A	p.L1479*	Substitution - Nonsense	Skin
COSM5391881	c.1875C>T	p.H625H	Substitution - coding silent	Skin
COSM4979052	c.5137G>A	p.V1713I	Substitution - Missense	Oesophagus
COSM2758212	c.1464C>T	p.N488N	Substitution - coding silent	Upper_aerodigestive_tract
COSM478049	c.5247G>T	p.T1749T	Substitution - coding silent	Kidney
COSM75580	c.3967C>T	p.R1323W	Substitution - Missense	Ovary
COSM40369	c.825G>A	p.Q275Q	Substitution - coding silent	Central_nervous_system
COSM478052	c.2809C>T	p.P937S	Substitution - Missense	Kidney
COSM5560794	c.5418C>T	p.N1806N	Substitution - coding silent	Prostate
COSM4548357	c.4456G>A	p.E1486K	Substitution - Missense	Skin
COSM4618024	c.5868C>A	p.S1956S	Substitution - coding silent	Large_intestine
COSM3840815	c.6103C>T	p.R2035C	Substitution - Missense	Breast
COSM3740095	c.2178G>A	p.Q726Q	Substitution - coding silent	Liver
COSM1411308	c.5407T>C	p.S1803P	Substitution - Missense	Large_intestine
COSM1713385	c.1391C>T	p.P464L	Substitution - Missense	Skin
COSM4581746	c.1271C>G	p.T424S	Substitution - Missense	Bone
COSM4097811	c.1533G>A	p.M511I	Substitution - Missense	Stomach
COSM140859	c.5798C>A	p.T1933K	Substitution - Missense	Skin
COSM262332	c.5506A>G	p.T1836A	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM1615491	c.5963-2A>G	p.?	Unknown	Liver
COSM2758214	c.1422G>A	p.P474P	Substitution - coding silent	Upper_aerodigestive_tract
COSM2758143	c.4863G>A	p.Q1621Q	Substitution - coding silent	Large_intestine
COSM5963639	c.3489G>C	p.M1163I	Substitution - Missense	Breast
COSM3545567	c.773C>T	p.P258L	Substitution - Missense	Skin
COSM4097817	c.379G>A	p.V127I	Substitution - Missense	Stomach
COSM1615492	c.2909C>G	p.P970R	Substitution - Missense	Liver
COSM5499402	c.3683G>A	p.R1228H	Substitution - Missense	Biliary_tract
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Large_intestine
COSM443687	c.1375C>G	p.Q459E	Substitution - Missense	Breast
COSM385679	c.843G>T	p.Q281H	Substitution - Missense	Lung
COSM75579	c.4045T>G	p.S1349A	Substitution - Missense	Ovary
COSM4097810	c.1660A>G	p.N554D	Substitution - Missense	Stomach
COSM4983303	c.4267C>G	p.Q1423E	Substitution - Missense	Oesophagus
COSM245969	c.2741C>T	p.P914L	Substitution - Missense	Prostate
COSM283144	c.5267C>A	p.S1756Y	Substitution - Missense	Large_intestine
COSM5042287	c.4927G>A	p.G1643R	Substitution - Missense	Liver
COSM5617019	c.4734A>G	p.V1578V	Substitution - coding silent	Lung
COSM5676556	c.5577C>G	p.T1859T	Substitution - coding silent	Soft_tissue
COSM5829020	c.2793-10_2793-3delTTTTTTTT	p.?	Unknown	Large_intestine
COSM5829020	c.2793-10_2793-3delTTTTTTTT	p.?	Unknown	Large_intestine
COSM2758155	c.4052C>T	p.A1351V	Substitution - Missense	Large_intestine
COSM723966	c.717A>T	p.P239P	Substitution - coding silent	Lung
COSM2758222	c.1129C>T	p.P377S	Substitution - Missense	Skin
COSM1026109	c.535C>A	p.P179T	Substitution - Missense	Endometrium
COSM5622599	c.4050A>T	p.K1350N	Substitution - Missense	Oesophagus
COSM276284	c.6056G>A	p.R2019Q	Substitution - Missense	Large_intestine
COSM4097806	c.3247C>T	p.Q1083*	Substitution - Nonsense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Endometrium
COSM1307307	c.490G>T	p.G164*	Substitution - Nonsense	Urinary_tract
COSM137207	c.4675C>T	p.L1559F	Substitution - Missense	Skin
COSM3545552	c.5240C>T	p.P1747L	Substitution - Missense	Skin
COSM4134465	c.2305C>G	p.Q769E	Substitution - Missense	Thyroid
COSM1751407	c.652G>A	p.D218N	Substitution - Missense	Urinary_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Endometrium
COSM3545564	c.1816C>T	p.L606F	Substitution - Missense	Skin
COSM3991655	c.4516A>G	p.K1506E	Substitution - Missense	Kidney
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM4097803	c.3748G>T	p.G1250*	Substitution - Nonsense	Stomach
COSM5391882	c.602C>T	p.P201L	Substitution - Missense	Skin
COSM3673102	c.2741C>A	p.P914Q	Substitution - Missense	Prostate
COSM4705973	c.3438C>G	p.G1146G	Substitution - coding silent	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM2758203	c.1753A>G	p.M585V	Substitution - Missense	Large_intestine
COSM5891176	c.1696C>T	p.P566S	Substitution - Missense	Skin
COSM1713384	c.5096C>T	p.P1699L	Substitution - Missense	Skin
COSM2758224	c.1095G>A	p.T365T	Substitution - coding silent	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM5783872	c.391+3C>A	p.?	Unknown	Breast
COSM302732	c.795A>G	p.Q265Q	Substitution - coding silent	Kidney
COSM5366109	c.3408T>C	p.S1136S	Substitution - coding silent	Large_intestine
COSM577035	c.1831G>T	p.G611C	Substitution - Missense	Endometrium
COSM1751406	c.3158A>G	p.N1053S	Substitution - Missense	Urinary_tract
COSM3545568	c.578C>T	p.S193F	Substitution - Missense	Skin
COSM4134464	c.2832T>A	p.D944E	Substitution - Missense	Thyroid
COSM4564628	c.1317_1318CC>TT	p.P440S	Substitution - Missense	Skin
COSM1026095	c.2019G>A	p.S673S	Substitution - coding silent	Endometrium
COSM1743873	c.5825C>G	p.S1942C	Substitution - Missense	Biliary_tract
COSM4097808	c.2938C>T	p.Q980*	Substitution - Nonsense	Stomach
COSM232857	c.2905C>T	p.R969W	Substitution - Missense	Skin
COSM5391879	c.4638C>T	p.S1546S	Substitution - coding silent	Skin
COSM4097812	c.1013T>C	p.M338T	Substitution - Missense	Stomach
COSM4097800	c.5167G>C	p.A1723P	Substitution - Missense	Stomach
COSM6008552	c.3070C>T	p.Q1024*	Substitution - Nonsense	Prostate
COSM302732	c.795A>G	p.Q265Q	Substitution - coding silent	Urinary_tract
COSM1026079	c.3353C>T	p.P1118L	Substitution - Missense	Stomach
COSM5588420	c.1287C>G	p.A429A	Substitution - coding silent	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM1026055	c.5785G>A	p.A1929T	Substitution - Missense	Endometrium
COSM3911153	c.4674C>T	p.S1558S	Substitution - coding silent	Skin
COSM1026053	c.5822C>T	p.A1941V	Substitution - Missense	Endometrium
COSM3363194	c.2460T>C	p.D820D	Substitution - coding silent	Kidney
COSM4846425	c.5867C>T	p.S1956F	Substitution - Missense	Cervix
COSM1258844	c.1541G>A	p.R514H	Substitution - Missense	Stomach
COSM1158362	c.2830G>A	p.D944N	Substitution - Missense	Pancreas
COSM5829022	c.2793-11_2793-3delTTTTTTTTT	p.?	Unknown	Large_intestine
COSM1026047	c.5982C>A	p.A1994A	Substitution - coding silent	Endometrium
COSM4460599	c.1172C>T	p.P391L	Substitution - Missense	Skin
COSM5001314	c.3256G>T	p.A1086S	Substitution - Missense	Pancreas
COSM4097816	c.513A>G	p.P171P	Substitution - coding silent	Stomach
COSM302732	c.795A>G	p.Q265Q	Substitution - coding silent	Central_nervous_system
COSM5429598	c.1235C>G	p.S412C	Substitution - Missense	Oesophagus
COSM1216865	c.3976C>T	p.P1326S	Substitution - Missense	Large_intestine
COSM1026104	c.1305C>T	p.F435F	Substitution - coding silent	Skin
COSM4097799	c.5688G>A	p.P1896P	Substitution - coding silent	Stomach
COSM1026065	c.5120A>C	p.K1707T	Substitution - Missense	Endometrium
COSM1161384	c.236-1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM139183	c.674A>T	p.H225L	Substitution - Missense	Skin
COSM4776410	c.3092A>G	p.Q1031R	Substitution - Missense	Soft_tissue
COSM22032	c.3178C>T	p.P1060S	Substitution - Missense	Breast
COSM5773267	c.3775C>T	p.P1259S	Substitution - Missense	Breast
COSM4705970	c.4692G>T	p.L1564F	Substitution - Missense	Large_intestine
COSM4961357	c.901G>A	p.G301R	Substitution - Missense	Liver
COSM4097814	c.828G>A	p.Q276Q	Substitution - coding silent	Oesophagus
COSM3545563	c.1893C>T	p.S631S	Substitution - coding silent	Skin
COSM1681633	c.2707A>C	p.N903H	Substitution - Missense	Large_intestine
COSM1026077	c.3605C>T	p.A1202V	Substitution - Missense	Endometrium
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM3840816	c.5384C>T	p.P1795L	Substitution - Missense	Breast
COSM3963496	c.3355C>T	p.Q1119*	Substitution - Nonsense	Lung
COSM3713231	c.6054C>T	p.S2018S	Substitution - coding silent	Upper_aerodigestive_tract
COSM3545551	c.5263C>T	p.P1755S	Substitution - Missense	Skin
COSM1741347	c.5095C>G	p.P1699A	Substitution - Missense	Urinary_tract
COSM1026087	c.2825A>C	p.E942A	Substitution - Missense	Endometrium
COSM5780937	c.1441C>T	p.Q481*	Substitution - Nonsense	Breast
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM1026111	c.428G>A	p.R143Q	Substitution - Missense	Endometrium
COSM227167	c.5236C>T	p.P1746S	Substitution - Missense	Skin
COSM262335	c.3357G>T	p.Q1119H	Substitution - Missense	Large_intestine
COSM385680	c.359G>T	p.R120L	Substitution - Missense	Lung
COSM219679	c.5423G>A	p.R1808Q	Substitution - Missense	Breast
COSM1026085	c.2983G>A	p.A995T	Substitution - Missense	Endometrium
COSM1026081	c.3205C>T	p.P1069S	Substitution - Missense	Endometrium
COSM1026100	c.1604C>T	p.S535L	Substitution - Missense	Endometrium
COSM4566652	c.4332_4333CC>TT	p.P1445S	Substitution - Missense	Skin
COSM4097807	c.3093A>G	p.Q1031Q	Substitution - coding silent	Stomach
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Lung
COSM5008490	c.716C>G	p.P239R	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM2758153	c.4149T>C	p.N1383N	Substitution - coding silent	Prostate
COSM4752410	c.1643A>C	p.Q548P	Substitution - Missense	Stomach
COSM1026102	c.1527A>G	p.G509G	Substitution - coding silent	Endometrium
COSM4097809	c.2042A>G	p.K681R	Substitution - Missense	Stomach
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM1483561	c.5368A>G	p.T1790A	Substitution - Missense	Breast
COSM2758153	c.4149T>C	p.N1383N	Substitution - coding silent	Prostate
COSM354861	c.5845C>G	p.L1949V	Substitution - Missense	Lung
COSM4097814	c.828G>A	p.Q276Q	Substitution - coding silent	Large_intestine
COSM1730843	c.4591A>G	p.I1531V	Substitution - Missense	Liver
COSM1713383	c.6109C>T	p.R2037*	Substitution - Nonsense	Skin
COSM478054	c.2590A>T	p.N864Y	Substitution - Missense	Kidney
COSM4498245	c.5164C>A	p.P1722T	Substitution - Missense	Skin
COSM5567605	c.5832A>G	p.S1944S	Substitution - coding silent	Prostate
COSM4950059	c.413_460del48	p.A138_M153del16	Deletion - In frame	Liver
COSM3545561	c.2965C>T	p.Q989*	Substitution - Nonsense	Skin
COSM402207	c.4495G>T	p.G1499*	Substitution - Nonsense	Lung
COSM335127	c.427C>T	p.R143*	Substitution - Nonsense	Lung
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM1026069	c.4469C>T	p.S1490L	Substitution - Missense	Skin
COSM478053	c.2630A>T	p.N877I	Substitution - Missense	Kidney
COSM3707718	c.4778C>T	p.P1593L	Substitution - Missense	Liver
COSM1196590	c.5515C>T	p.L1839F	Substitution - Missense	Lung
COSM1727269	c.4354G>T	p.V1452F	Substitution - Missense	Liver
COSM3713231	c.6054C>T	p.S2018S	Substitution - coding silent	Upper_aerodigestive_tract
COSM3911156	c.1120C>T	p.P374S	Substitution - Missense	Skin
COSM1411326	c.1316C>T	p.S439F	Substitution - Missense	Skin
COSM5057249	c.538G>T	p.A180S	Substitution - Missense	Stomach
COSM5909829	c.1697C>T	p.P566L	Substitution - Missense	Skin
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Large_intestine
COSM272996	c.6161C>T	p.A2054V	Substitution - Missense	Upper_aerodigestive_tract
COSM1483563	c.156C>G	p.F52L	Substitution - Missense	Breast
COSM5921709	c.44C>T	p.S15F	Substitution - Missense	Skin
COSM1026059	c.5293G>T	p.E1765*	Substitution - Nonsense	Endometrium
COSM1681633	c.2707A>C	p.N903H	Substitution - Missense	Large_intestine
COSM1615491	c.5963-2A>G	p.?	Unknown	Liver
COSM5202004	c.2759delC	p.P920fs*11	Deletion - Frameshift	Breast
COSM1026063	c.5189G>A	p.R1730Q	Substitution - Missense	Endometrium
COSM723965	c.149T>C	p.V50A	Substitution - Missense	Lung
COSM1411316	c.3292C>T	p.P1098S	Substitution - Missense	Large_intestine
COSM219679	c.5423G>A	p.R1808Q	Substitution - Missense	Breast
COSM1713383	c.6109C>T	p.R2037*	Substitution - Nonsense	Liver
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM1026116	c.178G>T	p.D60Y	Substitution - Missense	Endometrium
COSM124692	c.4766C>T	p.S1589F	Substitution - Missense	Upper_aerodigestive_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Soft_tissue
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM4979982	c.4660G>A	p.E1554K	Substitution - Missense	Oesophagus
COSM4566273	c.3396_3397CC>TT	p.P1133S	Substitution - Missense	Skin
COSM1681634	c.1739T>C	p.M580T	Substitution - Missense	Large_intestine
COSM4491885	c.3881C>T	p.P1294L	Substitution - Missense	Skin
COSM723964	c.4G>A	p.V2I	Substitution - Missense	Lung
COSM5924746	c.5170C>T	p.P1724S	Substitution - Missense	Skin
COSM3545566	c.1001C>T	p.S334F	Substitution - Missense	Skin
COSM2758177	c.3242G>T	p.S1081I	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM3545550	c.5783C>T	p.S1928F	Substitution - Missense	Skin
COSM5507386	c.649A>G	p.M217V	Substitution - Missense	Biliary_tract
COSM1190244	c.2750A>G	p.K917R	Substitution - Missense	Lung
COSM4097805	c.3546G>A	p.Q1182Q	Substitution - coding silent	Stomach
COSM4548357	c.4456G>A	p.E1486K	Substitution - Missense	Upper_aerodigestive_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM1326793	c.2962C>A	p.P988T	Substitution - Missense	Ovary
COSM4898590	c.5939T>C	p.L1980P	Substitution - Missense	Skin
COSM1681631	c.5788G>A	p.V1930I	Substitution - Missense	Lung
COSM2758214	c.1422G>A	p.P474P	Substitution - coding silent	Upper_aerodigestive_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM3736798	c.3872C>A	p.T1291N	Substitution - Missense	Skin
COSM2758150	c.4337C>T	p.A1446V	Substitution - Missense	Large_intestine
COSM4821766	c.1356G>A	p.Q452Q	Substitution - coding silent	Cervix
COSM3545553	c.5218C>T	p.P1740S	Substitution - Missense	Skin
COSM3545555	c.4682A>G	p.H1561R	Substitution - Missense	Skin
COSM2758214	c.1422G>A	p.P474P	Substitution - coding silent	Stomach
COSM4752411	c.1170T>G	p.F390L	Substitution - Missense	Stomach
COSM5902123	c.1529-8C>T	p.?	Unknown	Skin
COSM4581745	c.2643G>A	p.T881T	Substitution - coding silent	Liver
COSM1026111	c.428G>A	p.R143Q	Substitution - Missense	Large_intestine
COSM1026069	c.4469C>T	p.S1490L	Substitution - Missense	Large_intestine
COSM5934019	c.4391C>T	p.P1464L	Substitution - Missense	Skin
COSM4902018	c.5230C>T	p.P1744S	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM4611935	c.806_807insACA	p.Q285_L286insQ	Insertion - In frame	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM269705	c.5593A>G	p.M1865V	Substitution - Missense	Large_intestine
COSM1411309	c.4395G>A	p.S1465S	Substitution - coding silent	Large_intestine
COSM2153387	c.247C>A	p.L83I	Substitution - Missense	Central_nervous_system
COSM124692	c.4766C>T	p.S1589F	Substitution - Missense	Skin
COSM137208	c.1235C>T	p.S412F	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM4488843	c.3396C>T	p.L1132L	Substitution - coding silent	Skin
COSM2758190	c.2430C>T	p.N810N	Substitution - coding silent	Large_intestine
COSM75580	c.3967C>T	p.R1323W	Substitution - Missense	Ovary
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Lung
COSM2153387	c.247C>A	p.L83I	Substitution - Missense	Central_nervous_system
COSM1307305	c.4274G>T	p.S1425I	Substitution - Missense	Urinary_tract
COSM4383356	c.2591A>G	p.N864S	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Endometrium
COSM5057248	c.4687G>A	p.E1563K	Substitution - Missense	Stomach
COSM1411315	c.3416A>G	p.E1139G	Substitution - Missense	Large_intestine
COSM723976	c.5298G>A	p.L1766L	Substitution - coding silent	Lung
COSM4097814	c.828G>A	p.Q276Q	Substitution - coding silent	Stomach
COSM5442489	c.4107G>A	p.E1369E	Substitution - coding silent	Oesophagus
COSM4409233	c.4171C>T	p.P1391S	Substitution - Missense	Oesophagus
COSM1740615	c.458T>G	p.M153R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1026069	c.4469C>T	p.S1490L	Substitution - Missense	Skin
COSM6008551	c.5156C>T	p.S1719F	Substitution - Missense	Prostate
COSM1158362	c.2830G>A	p.D944N	Substitution - Missense	Pancreas
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM723977	c.5588G>T	p.G1863V	Substitution - Missense	Lung
COSM5660053	c.2893G>A	p.E965K	Substitution - Missense	Soft_tissue
COSM3911155	c.1325C>T	p.S442F	Substitution - Missense	Skin
COSM22032	c.3178C>T	p.P1060S	Substitution - Missense	Breast
COSM5444453	c.1536T>G	p.P512P	Substitution - coding silent	Oesophagus
COSM1026049	c.5925T>G	p.T1975T	Substitution - coding silent	Endometrium
COSM4134463	c.3706G>T	p.E1236*	Substitution - Nonsense	Thyroid
COSM75580	c.3967C>T	p.R1323W	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM2758224	c.1095G>A	p.T365T	Substitution - coding silent	Pancreas
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Liver
COSM4612411	c.828_830delGCA	p.Q285delQ	Deletion - In frame	Large_intestine
COSM4894860	c.554C>T	p.P185L	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Endometrium
COSM4423456	c.4999A>T	p.I1667F	Substitution - Missense	Central_nervous_system
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM4399590	c.1295C>T	p.P432L	Substitution - Missense	Skin
COSM5018510	c.5150C>T	p.A1717V	Substitution - Missense	Soft_tissue
COSM3545558	c.4067T>C	p.L1356P	Substitution - Missense	Skin
COSM139182	c.6116C>T	p.S2039F	Substitution - Missense	Skin
COSM723967	c.954G>C	p.W318C	Substitution - Missense	Lung
COSM5474277	c.5542G>A	p.A1848T	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM276283	c.6175C>T	p.R2059*	Substitution - Nonsense	Large_intestine
COSM4494649	c.4374C>T	p.S1458S	Substitution - coding silent	Skin
COSM5579059	c.3542C>T	p.P1181L	Substitution - Missense	Skin
COSM4799788	c.2931A>G	p.P977P	Substitution - coding silent	Liver
COSM1026051	c.5888G>A	p.S1963N	Substitution - Missense	Endometrium
COSM343281	c.2953C>T	p.Q985*	Substitution - Nonsense	Lung
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Lung
COSM1026073	c.4211C>A	p.S1404Y	Substitution - Missense	Endometrium
COSM1026100	c.1604C>T	p.S535L	Substitution - Missense	Cervix
COSM4535450	c.2193G>A	p.Q731Q	Substitution - coding silent	Skin
COSM4490861	c.3700C>T	p.P1234S	Substitution - Missense	Skin
COSM723970	c.2065C>A	p.P689T	Substitution - Missense	Lung
COSM1026097	c.1885G>A	p.V629M	Substitution - Missense	Endometrium
COSM3840818	c.5060C>G	p.S1687C	Substitution - Missense	Breast
COSM288756	c.4579A>G	p.K1527E	Substitution - Missense	Large_intestine
COSM2758193	c.2291G>A	p.G764E	Substitution - Missense	Large_intestine
COSM5818087	c.932A>T	p.Q311L	Substitution - Missense	Liver
COSM5514104	c.3425C>T	p.S1142F	Substitution - Missense	Skin
COSM4961357	c.901G>A	p.G301R	Substitution - Missense	Liver
COSM1681632	c.4772C>T	p.P1591L	Substitution - Missense	Liver
COSM2758227	c.943C>T	p.P315S	Substitution - Missense	Skin
COSM723971	c.2745G>A	p.K915K	Substitution - coding silent	Lung
COSM240842	c.3993G>T	p.R1331S	Substitution - Missense	Prostate
COSM5566115	c.1367G>A	p.R456K	Substitution - Missense	Prostate
COSM1286526	c.3551C>T	p.P1184L	Substitution - Missense	Autonomic_ganglia
COSM265627	c.4343_4345delAAG	p.E1448delE	Deletion - In frame	Large_intestine
COSM4952287	c.2915-1G>A	p.?	Unknown	Liver
COSM3840817	c.5194T>A	p.L1732M	Substitution - Missense	Breast
COSM4097806	c.3247C>T	p.Q1083*	Substitution - Nonsense	Stomach
COSM272996	c.6161C>T	p.A2054V	Substitution - Missense	Large_intestine
COSM5921710	c.5435C>T	p.S1812L	Substitution - Missense	Skin
COSM5821206	c.2070A>T	p.Q690H	Substitution - Missense	Liver
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM1026093	c.2246C>T	p.P749L	Substitution - Missense	Endometrium
COSM4097797	c.6056G>C	p.R2019P	Substitution - Missense	Stomach
COSM4832949	c.1707G>C	p.Q569H	Substitution - Missense	Cervix
COSM4097798	c.5945C>T	p.A1982V	Substitution - Missense	Stomach
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM1026104	c.1305C>T	p.F435F	Substitution - coding silent	Endometrium
COSM5514104	c.3425C>T	p.S1142F	Substitution - Missense	Biliary_tract
COSM5675717	c.6192A>C	p.*2064Y	Nonstop extension	Soft_tissue
COSM4799788	c.2931A>G	p.P977P	Substitution - coding silent	Liver
COSM5924745	c.5171C>T	p.P1724L	Substitution - Missense	Skin
COSM1026075	c.3811G>A	p.D1271N	Substitution - Missense	Endometrium
COSM283145	c.3626C>T	p.P1209L	Substitution - Missense	Large_intestine
COSM723973	c.2746A>T	p.K916*	Substitution - Nonsense	Lung
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM4433198	c.1676-4delT	p.?	Unknown	Skin
COSM5008575	c.2432A>G	p.D811G	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM313157	c.4853C>T	p.T1618I	Substitution - Missense	Lung
COSM1411322	c.2101C>G	p.P701A	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM4705972	c.3581G>A	p.G1194D	Substitution - Missense	Large_intestine
COSM5016655	c.4066_4067insA	p.L1356fs*37	Insertion - Frameshift	Kidney
COSM1026107	c.792G>A	p.Q264Q	Substitution - coding silent	Large_intestine
COSM4942132	c.1256A>T	p.Q419L	Substitution - Missense	Liver
COSM4097801	c.4559T>A	p.V1520D	Substitution - Missense	Stomach
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Urinary_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM443688	c.964C>G	p.P322A	Substitution - Missense	Breast
COSM1026069	c.4469C>T	p.S1490L	Substitution - Missense	Endometrium
COSM1326792	c.2303C>T	p.P768L	Substitution - Missense	Ovary
COSM723974	c.3173G>A	p.R1058K	Substitution - Missense	Lung
COSM2758214	c.1422G>A	p.P474P	Substitution - coding silent	Upper_aerodigestive_tract
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM4477999	c.2201C>T	p.S734F	Substitution - Missense	Skin
COSM4952287	c.2915-1G>A	p.?	Unknown	Liver
COSM1411327	c.1051G>A	p.G351S	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM1740615	c.458T>G	p.M153R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3371660	c.1728G>A	p.P576P	Substitution - coding silent	Thyroid
COSM4463724	c.1302C>T	p.S434S	Substitution - coding silent	Skin
COSM3939312	c.635C>T	p.S212F	Substitution - Missense	Oesophagus
COSM4567020	c.5385_5386CC>TT	p.L1796F	Substitution - Missense	Skin
COSM5829023	c.2793-13_2793-3delTTTTTTTTTTT	p.?	Unknown	Large_intestine
COSM459772	c.484G>T	p.E162*	Substitution - Nonsense	Cervix
COSM3840821	c.1035G>A	p.K345K	Substitution - coding silent	Breast
COSM135876	c.1390C>T	p.P464S	Substitution - Missense	Upper_aerodigestive_tract
COSM5581822	c.1171C>T	p.P391S	Substitution - Missense	Skin
COSM232858	c.4502C>T	p.P1501L	Substitution - Missense	Skin
COSM6008553	c.2113G>A	p.V705I	Substitution - Missense	Prostate
COSM219679	c.5423G>A	p.R1808Q	Substitution - Missense	Large_intestine
COSM1681634	c.1739T>C	p.M580T	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM5833955	c.2411delC	p.P804fs*14	Deletion - Frameshift	Breast
COSM3731657	c.4673C>T	p.S1558F	Substitution - Missense	Stomach
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Endometrium
COSM4705974	c.2944C>T	p.P982S	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM577039	c.3188C>T	p.P1063L	Substitution - Missense	Skin
COSM5561415	c.3399T>C	p.P1133P	Substitution - coding silent	Prostate
COSM1411312	c.3740C>T	p.S1247F	Substitution - Missense	Large_intestine
COSM32330	c.3573C>A	p.S1191R	Substitution - Missense	Breast
COSM3545570	c.358C>T	p.R120W	Substitution - Missense	Skin
COSM4485372	c.2926C>T	p.Q976*	Substitution - Nonsense	Skin
COSM5750136	c.2296A>T	p.M766L	Substitution - Missense	Stomach
COSM3693447	c.2914G>T	p.G972C	Substitution - Missense	Large_intestine
COSM5767757	c.2204A>G	p.N735S	Substitution - Missense	Breast
COSM5914302	c.3563C>T	p.S1188F	Substitution - Missense	Skin
COSM1172714	c.3194C>T	p.S1065F	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM374411	c.1034A>G	p.K345R	Substitution - Missense	Lung
COSM3734939	c.3686C>T	p.P1229L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4924324	c.5956A>T	p.R1986*	Substitution - Nonsense	Liver
COSM4291451	c.831A>G	p.Q277Q	Substitution - coding silent	Large_intestine
COSM1026091	c.2730C>T	p.N910N	Substitution - coding silent	Endometrium
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Large_intestine
COSM3840819	c.4270G>A	p.D1424N	Substitution - Missense	Breast
COSM262334	c.4624G>T	p.E1542*	Substitution - Nonsense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM2758183	c.2864A>C	p.N955T	Substitution - Missense	Liver
COSM135876	c.1390C>T	p.P464S	Substitution - Missense	Skin
COSM4545190	c.3728G>A	p.R1243K	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM1216866	c.2127G>T	p.Q709H	Substitution - Missense	Large_intestine
COSM1751407	c.652G>A	p.D218N	Substitution - Missense	Urinary_tract
COSM1026063	c.5189G>A	p.R1730Q	Substitution - Missense	Peritoneum
COSM3734554	c.2825_2828delAGGC	p.E942fs*91	Deletion - Frameshift	Pancreas
COSM224593	c.361G>A	p.D121N	Substitution - Missense	Skin
COSM4548353	c.4452G>A	p.M1484I	Substitution - Missense	Skin
COSM3545565	c.1249C>T	p.P417S	Substitution - Missense	Skin
COSM5891176	c.1696C>T	p.P566S	Substitution - Missense	Skin
COSM3545559	c.3593C>T	p.P1198L	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Bone
COSM1681632	c.4772C>T	p.P1591L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4816597	c.5773G>A	p.E1925K	Substitution - Missense	Cervix
COSM4790413	c.5495G>A	p.C1832Y	Substitution - Missense	Liver
COSM276284	c.6056G>A	p.R2019Q	Substitution - Missense	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM4097804	c.3549A>G	p.Q1183Q	Substitution - coding silent	Stomach
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM1615492	c.2909C>G	p.P970R	Substitution - Missense	Liver
COSM3758531	c.2247A>G	p.P749P	Substitution - coding silent	Large_intestine
COSM1740615	c.458T>G	p.M153R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1026057	c.5530G>T	p.E1844*	Substitution - Nonsense	Endometrium
COSM478051	c.4331T>C	p.V1444A	Substitution - Missense	Kidney
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Large_intestine
COSM2758127	c.5981C>T	p.A1994V	Substitution - Missense	Large_intestine
COSM1172714	c.3194C>T	p.S1065F	Substitution - Missense	Oesophagus
COSM1026067	c.4901C>T	p.A1634V	Substitution - Missense	Endometrium
COSM1751406	c.3158A>G	p.N1053S	Substitution - Missense	Urinary_tract
COSM1026083	c.3090_3092delGCA	p.Q1032delQ	Deletion - In frame	Large_intestine
COSM6017864	c.3169C>T	p.P1057S	Substitution - Missense	Skin
COSM219679	c.5423G>A	p.R1808Q	Substitution - Missense	Large_intestine
COSM1190245	c.2143C>A	p.Q715K	Substitution - Missense	Lung
COSM1411330	c.810G>A	p.Q270Q	Substitution - coding silent	Large_intestine
COSM325925	c.3238G>C	p.V1080L	Substitution - Missense	Lung
COSM1026079	c.3353C>T	p.P1118L	Substitution - Missense	Endometrium
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Liver
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Central_nervous_system
COSM5647360	c.946C>T	p.P316S	Substitution - Missense	Oesophagus
COSM478055	c.2213C>A	p.P738Q	Substitution - Missense	Kidney
COSM4816705	c.2494C>T	p.H832Y	Substitution - Missense	Cervix
COSM5744037	c.830_831insGCA	p.Q285_L286insQ	Insertion - In frame	Small_intestine
COSM4705975	c.1895A>G	p.Q632R	Substitution - Missense	Large_intestine
COSM262333	c.5126C>A	p.S1709Y	Substitution - Missense	Large_intestine
COSM392601	c.5636delC	p.P1879fs*9	Deletion - Frameshift	Lung
COSM4097814	c.828G>A	p.Q276Q	Substitution - coding silent	Biliary_tract
COSM1172714	c.3194C>T	p.S1065F	Substitution - Missense	Skin
COSM124693	c.4742G>A	p.R1581K	Substitution - Missense	Upper_aerodigestive_tract
COSM75578	c.5408C>A	p.S1803Y	Substitution - Missense	Ovary
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM1026114	c.319C>T	p.R107W	Substitution - Missense	Endometrium
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Bone
COSM1026071	c.4352T>C	p.M1451T	Substitution - Missense	Endometrium
COSM3840820	c.3909C>T	p.H1303H	Substitution - coding silent	Breast
COSM235025	c.2904C>T	p.N968N	Substitution - coding silent	Skin
COSM1681632	c.4772C>T	p.P1591L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1307310	c.13G>C	p.D5H	Substitution - Missense	Urinary_tract
COSM5009880	c.2602T>C	p.C868R	Substitution - Missense	Large_intestine
COSM3911154	c.2851G>A	p.E951K	Substitution - Missense	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM5921708	c.1939C>T	p.P647S	Substitution - Missense	Skin
COSM235026	c.4503C>T	p.P1501P	Substitution - coding silent	Skin
COSM1026089	c.2762G>A	p.R921Q	Substitution - Missense	Endometrium
COSM3785385	c.1831G>A	p.G611S	Substitution - Missense	Pancreas
COSM4097815	c.781C>T	p.Q261*	Substitution - Nonsense	Stomach
COSM2758212	c.1464C>T	p.N488N	Substitution - coding silent	Upper_aerodigestive_tract
COSM5561415	c.3399T>C	p.P1133P	Substitution - coding silent	Prostate
COSM3545569	c.394G>A	p.E132K	Substitution - Missense	Skin
COSM478050	c.4718C>A	p.P1573Q	Substitution - Missense	Kidney
COSM5883548	c.5731C>T	p.P1911S	Substitution - Missense	Skin
COSM3545557	c.4145C>T	p.A1382V	Substitution - Missense	Skin
COSM4473258	c.1839C>T	p.P613P	Substitution - coding silent	Skin
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM4433198	c.1676-4delT	p.?	Unknown	Oesophagus
COSM262333	c.5126C>A	p.S1709Y	Substitution - Missense	Large_intestine
COSM3545552	c.5240C>T	p.P1747L	Substitution - Missense	Skin
COSM5391880	c.3195C>T	p.S1065S	Substitution - coding silent	Skin
COSM4705969	c.5273C>T	p.P1758L	Substitution - Missense	Large_intestine
COSM335127	c.427C>T	p.R143*	Substitution - Nonsense	Endometrium
COSM4391987	c.2324A>G	p.N775S	Substitution - Missense	Prostate
COSM4134462	c.5640G>A	p.T1880T	Substitution - coding silent	Thyroid
COSM4950059	c.413_460del48	p.A138_M153del16	Deletion - In frame	Liver
COSM1026107	c.792G>A	p.Q264Q	Substitution - coding silent	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Prostate
COSM5887518	c.4726C>T	p.P1576S	Substitution - Missense	Skin
COSM1411323	c.1997delC	p.P666fs*12	Deletion - Frameshift	Stomach
COSM1026107	c.792G>A	p.Q264Q	Substitution - coding silent	Large_intestine
COSM3545566	c.1001C>T	p.S334F	Substitution - Missense	Skin
COSM225792	c.6043C>T	p.R2015*	Substitution - Nonsense	Skin
COSM1411326	c.1316C>T	p.S439F	Substitution - Missense	Large_intestine
COSM5594958	c.1550C>T	p.P517L	Substitution - Missense	Skin
COSM137209	c.496C>T	p.P166S	Substitution - Missense	Skin
COSM1307308	c.273G>A	p.W91*	Substitution - Nonsense	Urinary_tract
COSM1411323	c.1997delC	p.P666fs*12	Deletion - Frameshift	Large_intestine
COSM245968	c.807G>A	p.Q269Q	Substitution - coding silent	Kidney
COSM5464902	c.4608T>C	p.D1536D	Substitution - coding silent	Large_intestine
COSM4495907	c.4637C>T	p.S1546F	Substitution - Missense	Skin
COSM3991656	c.3199A>G	p.R1067G	Substitution - Missense	Kidney
COSM1026107	c.792G>A	p.Q264Q	Substitution - coding silent	Endometrium
COSM5744037	c.830_831insGCA	p.Q285_L286insQ	Insertion - In frame	Upper_aerodigestive_tract
COSM4400286	c.1023C>T	p.N341N	Substitution - coding silent	Skin
COSM4097813	c.894G>A	p.Q298Q	Substitution - coding silent	Stomach
COSM4598152	c.1466T>C	p.F489S	Substitution - Missense	Upper_aerodigestive_tract
COSM4790413	c.5495G>A	p.C1832Y	Substitution - Missense	Liver
COSM4097802	c.4181G>A	p.S1394N	Substitution - Missense	Stomach
COSM5626798	c.1854A>G	p.P618P	Substitution - coding silent	Oesophagus
COSM1026061	c.5252C>A	p.S1751Y	Substitution - Missense	Endometrium
COSM4581744	c.5109T>A	p.P1703P	Substitution - coding silent	Bone

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
22628150	mutation	Melanoma	A haplotype from the variants within NCOA6 showed an association with risk of melanoma (OR 1.49, 95% CI 1.17-1.88).

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q14686	884	S	Phosphoserine	MAPK; in vitro	No	None detected
Q14686	1047	R	Asymmetric dimethylarginine	-	No	None detected
Q14686	1058	R	Asymmetric dimethylarginine	-	Yes	p.R1058K (cancer: LUSC)
Q14686	1096	R	Asymmetric dimethylarginine	-	No	None detected
Q14686	1321	T	Phosphothreonine	-	No	None detected
Q14686	1819	K	N6-acetyllysine	-	No	None detected
Q14686	1822	K	N6-acetyllysine	-	No	None detected
Q14686	2018	S	Phosphoserine	-	No	None detected

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.977	6.356	0.394	0.0114	NS
BRCA	Breast invasive carcinoma	112	1100	6.346	6.638	0.318	6.26e-09	NS
CESC	Cervical and endocervical cancers	3	306	5.676	6.273	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.553	6.687	0.261	0.0164	NS
ESCA	Esophageal carcinoma	11	185	6.783	7.226	0.397	0.016	NS
GBM	Glioblastoma multiforme	5	166	6.063	6.235	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.069	6.27	0.19	0.0759	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.196	5.942	-0.169	0.000939	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.151	6.092	0.002	0.985	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.202	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.566	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.562	4.953	0.427	1.84e-06	NS
LUAD	Lung adenocarcinoma	59	517	6.042	6.261	0.31	0.000226	NS
LUSC	Lung squamous cell carcinoma	51	501	6.001	6.532	0.539	3.86e-10	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.916	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.819	6.029	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.556	5.884	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.225	6.156	-0.02	0.79	NS
READ	Rectum adenocarcinoma	10	167	6.208	6.95	0.737	0.00186	Over
SARC	Sarcoma	2	263	5.253	6.111	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.663	6.289	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.666	7.126	0.503	1.73e-07	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.021	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.112	6.085	-0.005	0.945	NS
THYM	Thymoma	2	120	6.19	6.135	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.864	6.206	0.264	0.00364	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.4
Autonomic ganglia	CHP212	9.4
Autonomic ganglia	IMR32	10.4
Autonomic ganglia	KELLY	9.5
Autonomic ganglia	KPNRTBM1	10.5
Autonomic ganglia	KPNSI9S	9.4
Autonomic ganglia	KPNYN	10
Autonomic ganglia	MHHNB11	9
Autonomic ganglia	NB1	9.9
Autonomic ganglia	NH6	10
Autonomic ganglia	SHSY5Y	10.3
Autonomic ganglia	SIMA	10.1
Autonomic ganglia	SKNAS	9.7
Autonomic ganglia	SKNBE2	9.8
Autonomic ganglia	SKNDZ	10.4
Autonomic ganglia	SKNFI	10
Autonomic ganglia	SKNSH	9.2
Biliary tract	HUCCT1	9.7
Biliary tract	HUH28	9.7
Biliary tract	SNU1079	9.9
Biliary tract	SNU1196	10.3
Biliary tract	SNU245	9.6
Biliary tract	SNU308	10.1
Biliary tract	SNU478	9.7
Bone	143B	9.8
Bone	A673	9.9
Bone	CADOES1	10.5
Bone	CAL78	9.8
Bone	G292CLONEA141B1	9.6
Bone	HOS	9.8
Bone	HS706T	9.4
Bone	HS737T	9.3
Bone	HS819T	9
Bone	HS821T	9.5
Bone	HS822T	9.1
Bone	HS863T	9.4
Bone	HS870T	8.8
Bone	HS888T	9.9
Bone	MG63	9.5
Bone	MHHES1	10.5
Bone	OUMS27	10
Bone	RDES	10.6
Bone	SJSA1	9.4
Bone	SKES1	9.7
Bone	SKNMC	10
Bone	SW1353	9.6
Bone	T173	9
Bone	TC71	9.6
Bone	U2OS	9.8
Breast	AU565	10.4
Breast	BT20	10.6
Breast	BT474	12.4
Breast	BT483	10.7
Breast	BT549	10.1
Breast	CAL120	10.2
Breast	CAL148	11.2
Breast	CAL51	9.9
Breast	CAL851	8.7
Breast	CAMA1	9.6
Breast	DU4475	9.8
Breast	EFM192A	9
Breast	EFM19	9.9
Breast	EVSAT	9
Breast	HCC1143	10.2
Breast	HCC1187	9.7
Breast	HCC1395	9.5
Breast	HCC1419	10.7
Breast	HCC1428	9.5
Breast	HCC1500	10.1
Breast	HCC1569	10.7
Breast	HCC1599	10.4
Breast	HCC1806	10.1
Breast	HCC1937	9.7
Breast	HCC1954	9.3
Breast	HCC202	9.1
Breast	HCC2157	10.1
Breast	HCC2218	8.9
Breast	HCC38	10.2
Breast	HCC70	9.5
Breast	HDQP1	9.6
Breast	HMC18	9.8
Breast	HS274T	9.5
Breast	HS281T	9.3
Breast	HS343T	9.3
Breast	HS578T	9.2
Breast	HS606T	9
Breast	HS739T	9.2
Breast	HS742T	8.8
Breast	JIMT1	10.4
Breast	KPL1	9.3
Breast	MCF7	9.4
Breast	MDAMB134VI	10.2
Breast	MDAMB157	9.5
Breast	MDAMB175VII	9.9
Breast	MDAMB231	9.9
Breast	MDAMB361	10.2
Breast	MDAMB415	9.4
Breast	MDAMB436	9.7
Breast	MDAMB453	9.9
Breast	MDAMB468	9.8
Breast	SKBR3	10.8
Breast	T47D	9.7
Breast	UACC812	11.3
Breast	UACC893	9.6
Breast	YMB1	10
Breast	ZR751	9.5
Breast	ZR7530	9.7
Central nervous system	1321N1	9.1
Central nervous system	42MGBA	9.8
Central nervous system	8MGBA	9.4
Central nervous system	A172	9.5
Central nervous system	AM38	9
Central nervous system	BECKER	9.3
Central nervous system	CAS1	9.9
Central nervous system	CCFSTTG1	9.6
Central nervous system	D283MED	9.5
Central nervous system	D341MED	10.2
Central nervous system	DAOY	9.3
Central nervous system	DBTRG05MG	9.5
Central nervous system	DKMG	9.5
Central nervous system	GAMG	9.8
Central nervous system	GB1	10.3
Central nervous system	GI1	9.8
Central nervous system	GMS10	10
Central nervous system	GOS3	9.5
Central nervous system	H4	9.1
Central nervous system	HS683	9.7
Central nervous system	KALS1	9.3
Central nervous system	KG1C	9.7
Central nervous system	KNS42	9.8
Central nervous system	KNS60	9.6
Central nervous system	KNS81	9
Central nervous system	KS1	9.9
Central nervous system	LN18	9.7
Central nervous system	LN229	9.8
Central nervous system	M059K	9.8
Central nervous system	MOGGCCM	10.1
Central nervous system	MOGGUVW	9.4
Central nervous system	NMCG1	9.6
Central nervous system	ONS76	10
Central nervous system	SF126	9.2
Central nervous system	SF295	9.3
Central nervous system	SNB19	9.4
Central nervous system	SNU1105	9.9
Central nervous system	SNU201	9.8
Central nervous system	SNU466	9.6
Central nervous system	SNU489	10.5
Central nervous system	SNU626	9.6
Central nervous system	SNU738	10.3
Central nervous system	SW1088	10.1
Central nervous system	SW1783	9.5
Central nervous system	T98G	9.8
Central nervous system	TM31	9.5
Central nervous system	U118MG	10
Central nervous system	U138MG	10.4
Central nervous system	U251MG	9.4
Central nervous system	U87MG	10.2
Central nervous system	YH13	9
Central nervous system	YKG1	9.8
Endometrium	AN3CA	9.6
Endometrium	COLO684	11.1
Endometrium	EFE184	9.4
Endometrium	EN	9.4
Endometrium	ESS1	9
Endometrium	HEC108	9.5
Endometrium	HEC151	8.7
Endometrium	HEC1A	9.7
Endometrium	HEC1B	9.9
Endometrium	HEC251	8.6
Endometrium	HEC265	9
Endometrium	HEC50B	8.9
Endometrium	HEC59	9.1
Endometrium	HEC6	9.4
Endometrium	ISHIKAWAHERAKLIO02ER	9.7
Endometrium	JHUEM1	9.4
Endometrium	JHUEM2	9.7
Endometrium	JHUEM3	9.8
Endometrium	KLE	9.1
Endometrium	MFE280	9.6
Endometrium	MFE296	10
Endometrium	MFE319	8.6
Endometrium	RL952	9.8
Endometrium	SNGM	9.6
Endometrium	SNU1077	9.8
Endometrium	SNU685	9.7
Endometrium	TEN	9.9
Haematopoietic and lymphoid	697	10
Haematopoietic and lymphoid	A3KAW	9.4
Haematopoietic and lymphoid	A4FUK	9.6
Haematopoietic and lymphoid	ALLSIL	10.6
Haematopoietic and lymphoid	AML193	9.5
Haematopoietic and lymphoid	AMO1	9.5
Haematopoietic and lymphoid	BCP1	9.3
Haematopoietic and lymphoid	BDCM	9
Haematopoietic and lymphoid	BL41	9.7
Haematopoietic and lymphoid	BL70	9.5
Haematopoietic and lymphoid	BV173	7.7
Haematopoietic and lymphoid	CA46	9.8
Haematopoietic and lymphoid	CI1	9.5
Haematopoietic and lymphoid	CMK115	9.2
Haematopoietic and lymphoid	CMK86	9.5
Haematopoietic and lymphoid	CMK	9.6
Haematopoietic and lymphoid	CMLT1	10.6
Haematopoietic and lymphoid	COLO775	9.7
Haematopoietic and lymphoid	DAUDI	9.1
Haematopoietic and lymphoid	DB	10.1
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	11
Haematopoietic and lymphoid	DOHH2	9.6
Haematopoietic and lymphoid	EB1	9.8
Haematopoietic and lymphoid	EB2	9.8
Haematopoietic and lymphoid	EHEB	9.5
Haematopoietic and lymphoid	EJM	10.2
Haematopoietic and lymphoid	EM2	10
Haematopoietic and lymphoid	EOL1	9.9
Haematopoietic and lymphoid	F36P	9.9
Haematopoietic and lymphoid	GA10	9.3
Haematopoietic and lymphoid	GDM1	9.4
Haematopoietic and lymphoid	GRANTA519	9.4
Haematopoietic and lymphoid	HDLM2	8.7
Haematopoietic and lymphoid	HDMYZ	9.7
Haematopoietic and lymphoid	HEL9217	10.2
Haematopoietic and lymphoid	HEL	10.2
Haematopoietic and lymphoid	HH	9.3
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	11
Haematopoietic and lymphoid	HS604T	9.4
Haematopoietic and lymphoid	HS611T	9.1
Haematopoietic and lymphoid	HS616T	9.2
Haematopoietic and lymphoid	HS751T	9.3
Haematopoietic and lymphoid	HT	9.4
Haematopoietic and lymphoid	HTK	9.6
Haematopoietic and lymphoid	HUNS1	9
Haematopoietic and lymphoid	HUT102	9.5
Haematopoietic and lymphoid	HUT78	9
Haematopoietic and lymphoid	JEKO1	10.5
Haematopoietic and lymphoid	JK1	9.5
Haematopoietic and lymphoid	JM1	10
Haematopoietic and lymphoid	JURKAT	10.4
Haematopoietic and lymphoid	JURLMK1	10.1
Haematopoietic and lymphoid	JVM2	8.9
Haematopoietic and lymphoid	JVM3	9.4
Haematopoietic and lymphoid	K562	8.8
Haematopoietic and lymphoid	KARPAS299	9.5
Haematopoietic and lymphoid	KARPAS422	10.2
Haematopoietic and lymphoid	KARPAS620	10.2
Haematopoietic and lymphoid	KASUMI1	9.5
Haematopoietic and lymphoid	KASUMI2	10.2
Haematopoietic and lymphoid	KASUMI6	9.8
Haematopoietic and lymphoid	KCL22	9.8
Haematopoietic and lymphoid	KE37	9.5
Haematopoietic and lymphoid	KE97	8.9
Haematopoietic and lymphoid	KG1	9.4
Haematopoietic and lymphoid	KHM1B	9.4
Haematopoietic and lymphoid	KIJK	9.3
Haematopoietic and lymphoid	KMH2	8.7
Haematopoietic and lymphoid	KMM1	10.2
Haematopoietic and lymphoid	KMS11	10.3
Haematopoietic and lymphoid	KMS12BM	10.2
Haematopoietic and lymphoid	KMS18	9.6
Haematopoietic and lymphoid	KMS20	10.4
Haematopoietic and lymphoid	KMS21BM	9.4
Haematopoietic and lymphoid	KMS26	10
Haematopoietic and lymphoid	KMS27	8.9
Haematopoietic and lymphoid	KMS28BM	10
Haematopoietic and lymphoid	KMS34	9.5
Haematopoietic and lymphoid	KO52	9.4
Haematopoietic and lymphoid	KOPN8	9.8
Haematopoietic and lymphoid	KU812	9.4
Haematopoietic and lymphoid	KYO1	9.7
Haematopoietic and lymphoid	L1236	9.8
Haematopoietic and lymphoid	L363	10.5
Haematopoietic and lymphoid	L428	9.1
Haematopoietic and lymphoid	L540	10.1
Haematopoietic and lymphoid	LAMA84	9.7
Haematopoietic and lymphoid	LOUCY	9.3
Haematopoietic and lymphoid	LP1	10.6
Haematopoietic and lymphoid	M07E	9.6
Haematopoietic and lymphoid	MC116	9.1
Haematopoietic and lymphoid	ME1	10.2
Haematopoietic and lymphoid	MEC1	9.5
Haematopoietic and lymphoid	MEC2	9.6
Haematopoietic and lymphoid	MEG01	9
Haematopoietic and lymphoid	MHHCALL2	9.9
Haematopoietic and lymphoid	MHHCALL3	10.4
Haematopoietic and lymphoid	MHHCALL4	10.1
Haematopoietic and lymphoid	MINO	9.9
Haematopoietic and lymphoid	MJ	9.2
Haematopoietic and lymphoid	MM1S	9.9
Haematopoietic and lymphoid	MOLM13	9.6
Haematopoietic and lymphoid	MOLM16	9.9
Haematopoietic and lymphoid	MOLM6	9.8
Haematopoietic and lymphoid	MOLP2	10
Haematopoietic and lymphoid	MOLP8	9.7
Haematopoietic and lymphoid	MOLT13	10.1
Haematopoietic and lymphoid	MOLT16	9.8
Haematopoietic and lymphoid	MOLT4	10
Haematopoietic and lymphoid	MONOMAC1	10
Haematopoietic and lymphoid	MONOMAC6	10.1
Haematopoietic and lymphoid	MOTN1	10.3
Haematopoietic and lymphoid	MUTZ5	10.1
Haematopoietic and lymphoid	MV411	10
Haematopoietic and lymphoid	NALM19	9.7
Haematopoietic and lymphoid	NALM1	10.1
Haematopoietic and lymphoid	NALM6	10.3
Haematopoietic and lymphoid	NAMALWA	9.5
Haematopoietic and lymphoid	NB4	10
Haematopoietic and lymphoid	NCIH929	9.4
Haematopoietic and lymphoid	NCO2	9.3
Haematopoietic and lymphoid	NOMO1	9.8
Haematopoietic and lymphoid	NUDHL1	9.7
Haematopoietic and lymphoid	NUDUL1	9.4
Haematopoietic and lymphoid	OCIAML2	10.3
Haematopoietic and lymphoid	OCIAML3	9.9
Haematopoietic and lymphoid	OCIAML5	9.9
Haematopoietic and lymphoid	OCILY10	9.7
Haematopoietic and lymphoid	OCILY19	10.5
Haematopoietic and lymphoid	OCILY3	9.4
Haematopoietic and lymphoid	OCIM1	9.3
Haematopoietic and lymphoid	OPM2	10.3
Haematopoietic and lymphoid	P12ICHIKAWA	10.5
Haematopoietic and lymphoid	P31FUJ	9.3
Haematopoietic and lymphoid	P3HR1	9.4
Haematopoietic and lymphoid	PCM6	10.4
Haematopoietic and lymphoid	PEER	9.4
Haematopoietic and lymphoid	PF382	10.5
Haematopoietic and lymphoid	PFEIFFER	9.5
Haematopoietic and lymphoid	PL21	10.2
Haematopoietic and lymphoid	RAJI	9.3
Haematopoietic and lymphoid	RCHACV	10.4
Haematopoietic and lymphoid	REC1	9.9
Haematopoietic and lymphoid	REH	9.9
Haematopoietic and lymphoid	RI1	10.1
Haematopoietic and lymphoid	RL	8.3
Haematopoietic and lymphoid	RPMI8226	9.2
Haematopoietic and lymphoid	RPMI8402	11.1
Haematopoietic and lymphoid	RS411	9.6
Haematopoietic and lymphoid	SEM	9.3
Haematopoietic and lymphoid	SET2	9.6
Haematopoietic and lymphoid	SIGM5	9.9
Haematopoietic and lymphoid	SKM1	10
Haematopoietic and lymphoid	SKMM2	10
Haematopoietic and lymphoid	SR786	10.5
Haematopoietic and lymphoid	ST486	9.6
Haematopoietic and lymphoid	SUDHL10	9.6
Haematopoietic and lymphoid	SUDHL1	10.1
Haematopoietic and lymphoid	SUDHL4	9.6
Haematopoietic and lymphoid	SUDHL5	9.5
Haematopoietic and lymphoid	SUDHL6	9.7
Haematopoietic and lymphoid	SUDHL8	10.2
Haematopoietic and lymphoid	SUPB15	9.3
Haematopoietic and lymphoid	SUPHD1	10.1
Haematopoietic and lymphoid	SUPM2	9.1
Haematopoietic and lymphoid	SUPT11	10.8
Haematopoietic and lymphoid	SUPT1	9.6
Haematopoietic and lymphoid	TALL1	10.8
Haematopoietic and lymphoid	TF1	10.4
Haematopoietic and lymphoid	THP1	9.3
Haematopoietic and lymphoid	TO175T	9.6
Haematopoietic and lymphoid	TOLEDO	10.3
Haematopoietic and lymphoid	U266B1	10.5
Haematopoietic and lymphoid	U937	9.8
Haematopoietic and lymphoid	UT7	10.2
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	9.3
Kidney	786O	9.5
Kidney	A498	9.4
Kidney	A704	8.9
Kidney	ACHN	8.8
Kidney	BFTC909	8.6
Kidney	CAKI1	9.4
Kidney	CAKI2	9.4
Kidney	CAL54	9.8
Kidney	KMRC1	9.1
Kidney	KMRC20	9.1
Kidney	KMRC2	8.8
Kidney	KMRC3	9.5
Kidney	OSRC2	10.5
Kidney	RCC10RGB	9.6
Kidney	SNU1272	9.5
Kidney	SNU349	8.7
Kidney	TUHR10TKB	10
Kidney	TUHR14TKB	9.7
Kidney	TUHR4TKB	9.9
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	9.3
Large intestine	C2BBE1	10.1
Large intestine	CCK81	9.6
Large intestine	CL11	10.1
Large intestine	CL14	10.4
Large intestine	CL34	9.7
Large intestine	CL40	9.5
Large intestine	COLO205	9.8
Large intestine	COLO320	10.3
Large intestine	COLO678	10.9
Large intestine	CW2	9.9
Large intestine	DLD1	9.8
Large intestine	GP2D	9.9
Large intestine	HCC56	9.5
Large intestine	HCT116	9.7
Large intestine	HCT15	9.9
Large intestine	HS675T	8.9
Large intestine	HS698T	9.4
Large intestine	HT115	9.3
Large intestine	HT29	10.1
Large intestine	HT55	11.3
Large intestine	KM12	9.9
Large intestine	LOVO	9.3
Large intestine	LS1034	10.2
Large intestine	LS123	10.1
Large intestine	LS180	9.6
Large intestine	LS411N	9.2
Large intestine	LS513	9.2
Large intestine	MDST8	10.2
Large intestine	NCIH508	8.7
Large intestine	NCIH716	9.5
Large intestine	NCIH747	10.1
Large intestine	OUMS23	9.8
Large intestine	RCM1	10
Large intestine	RKO	9.5
Large intestine	SKCO1	9.4
Large intestine	SNU1040	10.5
Large intestine	SNU1197	10
Large intestine	SNU175	10.4
Large intestine	SNU283	10.7
Large intestine	SNU407	9.9
Large intestine	SNU503	9.4
Large intestine	SNU61	9.4
Large intestine	SNU81	10.4
Large intestine	SNUC1	10
Large intestine	SNUC2A	10.2
Large intestine	SNUC4	9.8
Large intestine	SNUC5	10.2
Large intestine	SW1116	9.6
Large intestine	SW1417	10.3
Large intestine	SW1463	10.4
Large intestine	SW403	10.4
Large intestine	SW480	9.3
Large intestine	SW48	9.8
Large intestine	SW620	10.2
Large intestine	SW837	10.1
Large intestine	SW948	10.5
Large intestine	T84	10
Liver	ALEXANDERCELLS	9.1
Liver	C3A	9.8
Liver	HEP3B217	9.5
Liver	HEPG2	9.8
Liver	HLE	9.8
Liver	HLF	9.8
Liver	HUH1	9.9
Liver	HUH6	10
Liver	HUH7	9.5
Liver	JHH1	9.6
Liver	JHH2	9.9
Liver	JHH4	9.7
Liver	JHH5	10
Liver	JHH6	9.6
Liver	JHH7	9.8
Liver	LI7	9.9
Liver	PLCPRF5	9.4
Liver	SKHEP1	9.1
Liver	SNU182	9.2
Liver	SNU387	10
Liver	SNU398	9.8
Liver	SNU423	10
Liver	SNU449	10
Liver	SNU475	10.2
Liver	SNU761	9.8
Liver	SNU878	9
Liver	SNU886	9.7
Lung	A549	8.7
Lung	ABC1	9.5
Lung	BEN	10.1
Lung	CAL12T	9.7
Lung	CALU1	10.1
Lung	CALU3	10
Lung	CALU6	9
Lung	CHAGOK1	9.2
Lung	COLO668	10
Lung	COLO699	9.9
Lung	CORL105	10.1
Lung	CORL23	9.7
Lung	CORL24	10.7
Lung	CORL279	10.3
Lung	CORL311	11.1
Lung	CORL47	10.1
Lung	CORL51	10.7
Lung	CORL88	10.8
Lung	CORL95	10.8
Lung	CPCN	10.2
Lung	DMS114	9.5
Lung	DMS153	10.2
Lung	DMS273	9.5
Lung	DMS454	9.5
Lung	DMS53	9.5
Lung	DMS79	10
Lung	DV90	9
Lung	EBC1	9.7
Lung	EPLC272H	8.9
Lung	HARA	9.5
Lung	HCC1171	10.2
Lung	HCC1195	9.9
Lung	HCC15	9.5
Lung	HCC2279	9.1
Lung	HCC2935	10.2
Lung	HCC33	10.4
Lung	HCC366	9.3
Lung	HCC4006	8.5
Lung	HCC44	8.8
Lung	HCC78	9.6
Lung	HCC827	9.8
Lung	HCC95	9.7
Lung	HLC1	10.2
Lung	HLFA	9.2
Lung	HS229T	8.8
Lung	HS618T	9
Lung	IALM	9.6
Lung	KNS62	8.6
Lung	LC1F	10.3
Lung	LC1SQSF	9.8
Lung	LCLC103H	10.3
Lung	LCLC97TM1	9.5
Lung	LK2	8.7
Lung	LOUNH91	10
Lung	LU65	9.4
Lung	LU99	9.5
Lung	LUDLU1	10
Lung	LXF289	9.8
Lung	MORCPR	10
Lung	NCIH1048	10
Lung	NCIH1092	10
Lung	NCIH1105	10.8
Lung	NCIH1155	9.8
Lung	NCIH1184	10
Lung	NCIH1299	9.9
Lung	NCIH1339	9.6
Lung	NCIH1341	9.8
Lung	NCIH1355	9
Lung	NCIH1373	8.8
Lung	NCIH1385	10.5
Lung	NCIH1395	9.5
Lung	NCIH1435	9.8
Lung	NCIH1436	10.6
Lung	NCIH1437	9.6
Lung	NCIH146	10.5
Lung	NCIH1563	9.6
Lung	NCIH1568	9.8
Lung	NCIH1573	9.8
Lung	NCIH1581	10.6
Lung	NCIH1618	10.9
Lung	NCIH1623	9.7
Lung	NCIH1648	10.6
Lung	NCIH1650	10
Lung	NCIH1651	9
Lung	NCIH1666	9.7
Lung	NCIH1693	8.6
Lung	NCIH1694	9.5
Lung	NCIH1703	10
Lung	NCIH1734	9.1
Lung	NCIH1755	9.6
Lung	NCIH1781	9.5
Lung	NCIH1792	9.9
Lung	NCIH1793	10.3
Lung	NCIH1836	10.1
Lung	NCIH1838	10.1
Lung	NCIH1869	9.6
Lung	NCIH1876	10.3
Lung	NCIH1915	9.1
Lung	NCIH1930	10.4
Lung	NCIH1944	8.9
Lung	NCIH1963	10.4
Lung	NCIH196	10.1
Lung	NCIH1975	9.7
Lung	NCIH2009	10.1
Lung	NCIH2023	9.1
Lung	NCIH2029	10.4
Lung	NCIH2030	9.5
Lung	NCIH2066	10
Lung	NCIH2081	10.1
Lung	NCIH2085	10
Lung	NCIH2087	8.9
Lung	NCIH209	10.2
Lung	NCIH2106	10.3
Lung	NCIH2110	9
Lung	NCIH211	9.8
Lung	NCIH2122	9.5
Lung	NCIH2126	10.6
Lung	NCIH2141	11.3
Lung	NCIH2170	10.2
Lung	NCIH2171	10.1
Lung	NCIH2172	9.9
Lung	NCIH2196	10.2
Lung	NCIH2227	10.7
Lung	NCIH2228	9.2
Lung	NCIH226	9.4
Lung	NCIH2286	9.8
Lung	NCIH2291	9.2
Lung	NCIH2342	10
Lung	NCIH2347	9.4
Lung	NCIH23	9.9
Lung	NCIH2405	9.9
Lung	NCIH2444	10
Lung	NCIH292	9.6
Lung	NCIH322	9.9
Lung	NCIH3255	10.2
Lung	NCIH358	9.6
Lung	NCIH441	9.2
Lung	NCIH446	9.9
Lung	NCIH460	8.6
Lung	NCIH510	10.4
Lung	NCIH520	9.5
Lung	NCIH522	9.8
Lung	NCIH524	9.8
Lung	NCIH526	10.4
Lung	NCIH596	10.3
Lung	NCIH647	9.8
Lung	NCIH650	10
Lung	NCIH661	9.9
Lung	NCIH69	10.3
Lung	NCIH727	10.2
Lung	NCIH810	9.9
Lung	NCIH82	9.7
Lung	NCIH838	9.2
Lung	NCIH841	9.9
Lung	NCIH854	10.6
Lung	NCIH889	9.2
Lung	PC14	9.4
Lung	RERFLCAD1	9.7
Lung	RERFLCAD2	8.9
Lung	RERFLCAI	8
Lung	RERFLCKJ	9.6
Lung	RERFLCMS	8.9
Lung	RERFLCSQ1	9.6
Lung	SBC5	9.4
Lung	SCLC21H	11.1
Lung	SHP77	9.4
Lung	SKLU1	9.8
Lung	SKMES1	9.2
Lung	SQ1	9.3
Lung	SW1271	11
Lung	SW1573	10.2
Lung	SW900	9.1
Lung	VMRCLCD	10
Lung	VMRCLCP	10.5
Oesophagus	COLO680N	9.9
Oesophagus	ECGI10	9.3
Oesophagus	KYSE140	8.9
Oesophagus	KYSE150	10.2
Oesophagus	KYSE180	9.7
Oesophagus	KYSE270	10.2
Oesophagus	KYSE30	10.3
Oesophagus	KYSE410	9.6
Oesophagus	KYSE450	9.5
Oesophagus	KYSE510	9.7
Oesophagus	KYSE520	9.6
Oesophagus	KYSE70	9.6
Oesophagus	OE19	10.1
Oesophagus	OE33	9.9
Oesophagus	TE10	9.7
Oesophagus	TE11	9.5
Oesophagus	TE14	10.5
Oesophagus	TE15	9.7
Oesophagus	TE1	9.6
Oesophagus	TE4	9.2
Oesophagus	TE5	10.4
Oesophagus	TE6	9.8
Oesophagus	TE8	10.2
Oesophagus	TE9	9.2
Oesophagus	TT	10.1
Ovary	59M	9.5
Ovary	A2780	9.5
Ovary	CAOV3	8.3
Ovary	CAOV4	10.4
Ovary	COLO704	10.7
Ovary	COV318	10.3
Ovary	COV362	8.8
Ovary	COV434	9.3
Ovary	COV504	9.6
Ovary	COV644	9.1
Ovary	EFO21	10.3
Ovary	EFO27	9.8
Ovary	ES2	8.9
Ovary	FUOV1	10.6
Ovary	HEYA8	8.8
Ovary	HS571T	8.9
Ovary	IGROV1	9.9
Ovary	JHOC5	9.6
Ovary	JHOM1	9.6
Ovary	JHOM2B	10.8
Ovary	JHOS2	9.1
Ovary	JHOS4	9.8
Ovary	KURAMOCHI	10.3
Ovary	MCAS	8.6
Ovary	NIHOVCAR3	9.7
Ovary	OAW28	9.8
Ovary	OAW42	9.2
Ovary	OC314	9.8
Ovary	OC316	9.7
Ovary	ONCODG1	9.9
Ovary	OV56	8.9
Ovary	OV7	9.6
Ovary	OV90	10.1
Ovary	OVCAR4	9.7
Ovary	OVCAR8	9.5
Ovary	OVISE	9.1
Ovary	OVK18	10
Ovary	OVKATE	9.5
Ovary	OVMANA	9.1
Ovary	OVSAHO	10.4
Ovary	OVTOKO	8.4
Ovary	RMGI	9
Ovary	RMUGS	9.5
Ovary	SKOV3	9.7
Ovary	SNU119	10
Ovary	SNU840	9.8
Ovary	SNU8	9.9
Ovary	TOV112D	9.7
Ovary	TOV21G	9.6
Ovary	TYKNU	9.2
Pancreas	ASPC1	10.3
Pancreas	BXPC3	9.9
Pancreas	CAPAN1	9.8
Pancreas	CAPAN2	9.4
Pancreas	CFPAC1	9.6
Pancreas	DANG	9.3
Pancreas	HPAC	10.5
Pancreas	HPAFII	9.8
Pancreas	HS766T	10.1
Pancreas	HUPT3	9.2
Pancreas	HUPT4	9.8
Pancreas	KCIMOH1	9.5
Pancreas	KLM1	10.4
Pancreas	KP2	9.4
Pancreas	KP3	9.1
Pancreas	KP4	9.5
Pancreas	L33	9.8
Pancreas	MIAPACA2	10
Pancreas	PANC0203	9.6
Pancreas	PANC0213	10.4
Pancreas	PANC0327	9.6
Pancreas	PANC0403	9.5
Pancreas	PANC0504	9.6
Pancreas	PANC0813	9.7
Pancreas	PANC1005	9.6
Pancreas	PANC1	9.3
Pancreas	PATU8902	9.4
Pancreas	PATU8988S	9.6
Pancreas	PATU8988T	10.1
Pancreas	PK1	9.9
Pancreas	PK45H	9.8
Pancreas	PK59	10.4
Pancreas	PL45	9.6
Pancreas	PSN1	9.7
Pancreas	QGP1	10
Pancreas	SNU213	9.9
Pancreas	SNU324	10.2
Pancreas	SNU410	10.1
Pancreas	SU8686	10
Pancreas	SUIT2	9.9
Pancreas	SW1990	9.7
Pancreas	T3M4	9.7
Pancreas	TCCPAN2	9.3
Pancreas	YAPC	10.1
Pleura	ACCMESO1	9.4
Pleura	DM3	9.3
Pleura	ISTMES1	9.7
Pleura	ISTMES2	9.5
Pleura	JL1	10.1
Pleura	MPP89	9.9
Pleura	MSTO211H	8.9
Pleura	NCIH2052	10
Pleura	NCIH2452	9.4
Pleura	NCIH28	9.4
Prostate	22RV1	9.6
Prostate	DU145	9
Prostate	LNCAPCLONEFGC	9.6
Prostate	MDAPCA2B	9.6
Prostate	NCIH660	10.3
Prostate	PC3	9.2
Prostate	VCAP	9.7
Salivary gland	A253	9.6
Salivary gland	YD15	9.5
Skin	A101D	9.6
Skin	A2058	9.6
Skin	A375	9.7
Skin	C32	8.9
Skin	CHL1	10.1
Skin	CJM	10.8
Skin	COLO679	9.4
Skin	COLO741	9.4
Skin	COLO783	10.6
Skin	COLO792	9.2
Skin	COLO800	9.9
Skin	COLO818	9.5
Skin	COLO829	9.9
Skin	COLO849	9.7
Skin	G361	9.5
Skin	GRM	10.2
Skin	HMCB	10.4
Skin	HS294T	10.3
Skin	HS600T	8.9
Skin	HS688AT	9.3
Skin	HS695T	9.1
Skin	HS839T	9.2
Skin	HS852T	10.2
Skin	HS895T	8.5
Skin	HS934T	9.5
Skin	HS936T	9.6
Skin	HS939T	9.6
Skin	HS940T	9.5
Skin	HS944T	9.6
Skin	HT144	9.3
Skin	IGR1	9.4
Skin	IGR37	9.7
Skin	IGR39	10
Skin	IPC298	9.1
Skin	K029AX	9.2
Skin	LOXIMVI	9.7
Skin	MALME3M	9.3
Skin	MDAMB435S	9
Skin	MELHO	9.4
Skin	MELJUSO	9.3
Skin	MEWO	9.5
Skin	RPMI7951	10.1
Skin	RVH421	10.1
Skin	SH4	9.9
Skin	SKMEL1	9.9
Skin	SKMEL24	9.2
Skin	SKMEL28	9.3
Skin	SKMEL2	9.4
Skin	SKMEL30	9.8
Skin	SKMEL31	9.6
Skin	SKMEL3	9.6
Skin	SKMEL5	9.5
Skin	UACC257	9.5
Skin	UACC62	9.5
Skin	WM115	9.7
Skin	WM1799	9.8
Skin	WM2664	9.7
Skin	WM793	10.5
Skin	WM88	9.9
Skin	WM983B	10
Small intestine	HUTU80	9.8
Soft tissue	A204	9.5
Soft tissue	G401	9.5
Soft tissue	G402	9.4
Soft tissue	GCT	9.5
Soft tissue	HS729	10.3
Soft tissue	HT1080	9.1
Soft tissue	KYM1	9.7
Soft tissue	MESSA	9.3
Soft tissue	RD	10.1
Soft tissue	RH30	10.9
Soft tissue	RH41	10.7
Soft tissue	RKN	9.7
Soft tissue	S117	10.3
Soft tissue	SJRH30	10.4
Soft tissue	SKLMS1	9.9
Soft tissue	SKUT1	9.8
Soft tissue	TE125T	9.1
Soft tissue	TE159T	9.3
Soft tissue	TE441T	9.8
Soft tissue	TE617T	9.6
Stomach	2313287	10.2
Stomach	AGS	9.9
Stomach	AZ521	9.3
Stomach	ECC10	10.9
Stomach	ECC12	9.9
Stomach	FU97	10.1
Stomach	GCIY	9.3
Stomach	GSS	10.9
Stomach	GSU	9.7
Stomach	HGC27	9.6
Stomach	HS746T	9.9
Stomach	HUG1N	10.4
Stomach	IM95	9.1
Stomach	KATOIII	9.8
Stomach	KE39	10.2
Stomach	LMSU	9.8
Stomach	MKN1	9.6
Stomach	MKN45	10.1
Stomach	MKN74	10.7
Stomach	MKN7	10.4
Stomach	NCCSTCK140	10.7
Stomach	NCIN87	9.6
Stomach	NUGC2	9.6
Stomach	NUGC3	10.1
Stomach	NUGC4	9.3
Stomach	OCUM1	9.4
Stomach	RERFGC1B	10.4
Stomach	SH10TC	9.6
Stomach	SNU16	10.1
Stomach	SNU1	9.8
Stomach	SNU216	11.3
Stomach	SNU520	9.6
Stomach	SNU5	9.3
Stomach	SNU601	10.1
Stomach	SNU620	10.3
Stomach	SNU668	9.9
Stomach	SNU719	10
Stomach	TGBC11TKB	10.1
Thyroid	8305C	10.5
Thyroid	8505C	10
Thyroid	BCPAP	11
Thyroid	BHT101	9.2
Thyroid	CAL62	10.3
Thyroid	CGTHW1	9.7
Thyroid	FTC133	9.8
Thyroid	FTC238	9.9
Thyroid	ML1	9.3
Thyroid	SW579	9.7
Thyroid	TT2609C02	9.8
Thyroid	TT	10.2
Upper aerodigestive tract	BHY	10.2
Upper aerodigestive tract	BICR16	9
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.4
Upper aerodigestive tract	BICR31	10
Upper aerodigestive tract	BICR56	9.9
Upper aerodigestive tract	BICR6	9.6
Upper aerodigestive tract	CAL27	9.7
Upper aerodigestive tract	CAL33	10
Upper aerodigestive tract	DETROIT562	9.3
Upper aerodigestive tract	FADU	9.3
Upper aerodigestive tract	HS840T	9.3
Upper aerodigestive tract	HSC2	9.7
Upper aerodigestive tract	HSC3	8.9
Upper aerodigestive tract	HSC4	11
Upper aerodigestive tract	PECAPJ15	9.9
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	9.4
Upper aerodigestive tract	PECAPJ49	9.9
Upper aerodigestive tract	SCC15	10
Upper aerodigestive tract	SCC25	9.6
Upper aerodigestive tract	SCC4	9.7
Upper aerodigestive tract	SCC9	10.1
Upper aerodigestive tract	SNU1076	10.2
Upper aerodigestive tract	SNU1214	9.3
Upper aerodigestive tract	SNU46	9.2
Upper aerodigestive tract	SNU899	10.3
Upper aerodigestive tract	YD10B	9.8
Upper aerodigestive tract	YD38	12.1
Upper aerodigestive tract	YD8	10.4
Urinary tract	5637	9.8
Urinary tract	639V	10.6
Urinary tract	647V	10.3
Urinary tract	BC3C	9.9
Urinary tract	BFTC905	10.1
Urinary tract	CAL29	10.3
Urinary tract	HS172T	9.1
Urinary tract	HT1197	9.3
Urinary tract	HT1376	9.7
Urinary tract	J82	10.9
Urinary tract	JMSU1	10.6
Urinary tract	KMBC2	11.2
Urinary tract	KU1919	10.1
Urinary tract	RT11284	9.7
Urinary tract	RT112	9.9
Urinary tract	RT4	9.5
Urinary tract	SCABER	9.4
Urinary tract	SW1710	10.3
Urinary tract	SW780	10.5
Urinary tract	T24	10.4
Urinary tract	TCCSUP	10.1
Urinary tract	UMUC1	9.9
Urinary tract	UMUC3	9.2
Urinary tract	VMCUB1	10.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	11.6
Adrenal gland	10.1
Appendix	12.5
Bone marrow	9.1
Breast	11
Cerebral cortex	18.6
Cervix, uterine	16.4
Colon	12.5
Duodenum	13.6
Endometrium	17.8
Epididymis	14.6
Esophagus	12.1
Fallopian tube	18.2
Gallbladder	14
Heart muscle	6.2
Kidney	10.7
Liver	4.4
Lung	15.6
Lymph node	10.5
Ovary	14.2
Pancreas	2.6
Parathyroid gland	41.8
Placenta	19.2
Prostate	15.5
Rectum	16.2
Salivary gland	5.6
Seminal vesicle	15.7
Skeletal muscle	3.3
Skin	16.1
Small intestine	13.5
Smooth muscle	19.2
Spleen	13.2
Stomach	10.8
Testis	34.9
Thyroid gland	22.9
Tonsil	9.8
Urinary bladder	11.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
21703850	underexpression	Wilms Tumour	TSPAN3, NCOA6, CDO1, MPP2 and MCM2 were confirmed to be down-regulated in relapse WT, and TSPAN3 and NCOA6 were also validated in an independent sample group.
15561801	copy number gain; overexpression	Breast Carcinoma; Colon Carcinoma; Lung Carcinoma	The NRC gene is also amplified and overexpressed in breast, colon, and lung cancers.

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.641	4.01e-48	1.7	36.4	61.9	Gain
BRCA	Breast invasive carcinoma	1075	0.549	1.31e-85	5.4	51.7	42.9	Gain
CESC	Cervical and endocervical cancers	292	0.483	1.88e-18	2.4	53.4	44.2	Gain
COAD	Colon adenocarcinoma	449	0.688	3.24e-64	0	28.1	71.9	Gain
ESCA	Esophageal carcinoma	183	0.538	3.79e-15	2.2	31.1	66.7	Gain
GBM	Glioblastoma multiforme	147	0.332	3.88e-05	2	61.9	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.475	2.92e-30	2.9	54.5	42.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.195	6.76e-06	0	77.3	22.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.47	3.33e-17	0.3	64.2	35.4	Gain
LAML	Acute Myeloid Leukemia	166	0.316	3.28e-05	1.8	97.6	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.153	0.000505	0.6	90.8	8.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.301	4.55e-09	2.7	65.9	31.3	Neutral
LUAD	Lung adenocarcinoma	512	0.525	1.36e-37	10.5	46.9	42.6	Gain
LUSC	Lung squamous cell carcinoma	498	0.476	1.45e-29	5.6	38	56.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.581	1.85e-28	3	37	60	Gain
PAAD	Pancreatic adenocarcinoma	177	0.476	2.06e-11	2.8	73.4	23.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.328	2.01e-05	1.9	92	6.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.291	5.08e-11	3.5	90	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.587	1.48e-16	0	11.6	88.4	Gain
SARC	Sarcoma	255	0.33	6.93e-08	5.9	56.1	38	Gain
SKCM	Skin Cutaneous Melanoma	367	0.592	4.74e-36	2.2	49.3	48.5	Gain
STAD	Stomach adenocarcinoma	413	0.688	2.77e-59	0.7	35.4	63.9	Gain
TGCT	Testicular Germ Cell Tumors	150	0.145	0.0768	9.3	62.7	28	Neutral
THCA	Thyroid carcinoma	497	0.206	3.64e-06	0.2	97.4	2.4	Neutral
THYM	Thymoma	119	-0.018	0.849	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.368	1.03e-18	2	72.8	25.1	Neutral

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.39	0	17	408	-0.244	5.92e-13	Decreased
BRCA	Breast invasive carcinoma	-0.322	0	83	785	-0.08	1.04e-07	NS/NA
CESC	Cervical and endocervical cancers	-0.301	8.31e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.514	0	19	297	-0.005	0.174	NS/NA
ESCA	Esophageal carcinoma	-0.366	1.96e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.117	0.352	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.29	6.94e-12	20	522	0.002	0.00577	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.071	0.191	24	319	0.004	0.004	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.332	5.5e-09	23	275	0.007	0.424	NS/NA
LAML	Acute Myeloid Leukemia	-0.174	0.0233	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.034	0.439	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.322	2.59e-11	41	373	-0.316	3.83e-29	Decreased
LUAD	Lung adenocarcinoma	-0.401	0	21	456	-0.13	2.08e-08	NS/NA
LUSC	Lung squamous cell carcinoma	-0.439	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.338	3.2e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.269	0.000202	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.255	2.55e-09	35	498	-0.143	1.97e-10	NS/NA
READ	Rectum adenocarcinoma	-0.525	2.85e-08	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.281	4.01e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.301	3.1e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.566	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.569	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.122	0.00402	50	509	-0.136	1.56e-06	NS/NA
THYM	Thymoma	-0.203	0.0254	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.231	4.86e-07	34	431	-0.239	9.7e-17	Decreased

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	3	High
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0267	Significant	24476821
BRCA	Breast invasive carcinoma	521	6.68e-11	Significant	23000897
COAD	Colon adenocarcinoma	149	3.1e-14	Significant	22810696
GBM	Glioblastoma multiforme	157	5.66e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00019	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00282	Significant	26536169
LGG	Brain Lower Grade Glioma	513	5.53e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.048	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0172	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00357	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0577	NS	26544944
READ	Rectum adenocarcinoma	67	1.19e-05	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000646	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.42e-18	Significant	25079317
THCA	Thyroid carcinoma	391	5.87e-08	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000755	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.234	0.317	NS
BRCA	Breast invasive carcinoma	1079	1.016	0.943	NS
CESC	Cervical and endocervical cancers	291	1.355	0.394	NS
COAD	Colon adenocarcinoma	439	1.015	0.96	NS
ESCA	Esophageal carcinoma	184	0.799	0.491	NS
GBM	Glioblastoma multiforme	158	1.011	0.964	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.86	0.437	NS
KIRC	Kidney renal clear cell carcinoma	531	0.554	0.00744	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.711	0.294	NS
LAML	Acute Myeloid Leukemia	149	0.913	0.778	NS
LGG	Brain Lower Grade Glioma	511	0.764	0.266	NS
LIHC	Liver hepatocellular carcinoma	365	1.651	0.0376	Shorter
LUAD	Lung adenocarcinoma	502	1.314	0.195	NS
LUSC	Lung squamous cell carcinoma	494	1.262	0.226	NS
OV	Ovarian serous cystadenocarcinoma	303	1.377	0.143	NS
PAAD	Pancreatic adenocarcinoma	177	1.429	0.236	NS
PCPG	Pheochromocytoma and Paraganglioma	179	679568717.963	0.0658	NS
PRAD	Prostate adenocarcinoma	497	2.683	0.279	NS
READ	Rectum adenocarcinoma	159	1.013	0.984	NS
SARC	Sarcoma	259	1.963	0.0207	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.419	0.0715	NS
STAD	Stomach adenocarcinoma	388	0.957	0.848	NS
TGCT	Testicular Germ Cell Tumors	134	1.128	0.932	NS
THCA	Thyroid carcinoma	500	1.244	0.775	NS
THYM	Thymoma	119	0.229	0.151	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.762	0.0556	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.022	0.658	NS
BRCA	Breast invasive carcinoma	1071	0.023	0.445	NS
CESC	Cervical and endocervical cancers	167	0.069	0.373	NS
COAD	Colon adenocarcinoma	445	0.095	0.0444	Higher
ESCA	Esophageal carcinoma	162	-0.049	0.539	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.021	0.655	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.119	0.00597	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.137	0.027	Higher
LIHC	Liver hepatocellular carcinoma	347	0.154	0.00416	Higher
LUAD	Lung adenocarcinoma	507	0.075	0.091	NS
LUSC	Lung squamous cell carcinoma	497	0.1	0.0251	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.094	0.104	NS
PAAD	Pancreatic adenocarcinoma	176	-0.006	0.935	NS
READ	Rectum adenocarcinoma	156	0.121	0.131	NS
SKCM	Skin Cutaneous Melanoma	410	-0.108	0.0287	Lower
STAD	Stomach adenocarcinoma	392	-0.062	0.221	NS
TGCT	Testicular Germ Cell Tumors	81	-0.246	0.027	Lower
THCA	Thyroid carcinoma	499	0.013	0.777	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.087	0.0509	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.029	0.638	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.106	0.0175	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.03	0.497	NS
LGG	Brain Lower Grade Glioma	514	0.068	0.125	NS
LIHC	Liver hepatocellular carcinoma	366	0.159	0.00231	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.078	0.181	NS
PAAD	Pancreatic adenocarcinoma	176	0.05	0.514	NS
STAD	Stomach adenocarcinoma	406	-0.245	5.96e-07	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.201	2.69e-06	Higher

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for NCOA6.

Summary
Symbol	NCOA6
Name	nuclear receptor coactivator 6
Aliases	KIAA0181; RAP250; NRC; nuclear receptor coactivator RAP250; activating signal cointegrator-2; peroxisome pro ......
Location	20q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for NCOA6.