CR2Cancer

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00004 ATPase family associated with various cellular activities (AAA)
PF01426 BAH domain
PF09079 CDC6

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006270 DNA replication initiation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition
Molecular Function	GO:0003682 chromatin binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000808 origin recognition complex GO:0005664 nuclear origin of replication recognition complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04110 Cell cycle
Reactome	R-HSA-176187: Activation of ATR in response to replication stress R-HSA-68962: Activation of the pre-replicative complex R-HSA-68616: Assembly of the ORC complex at the origin of replication R-HSA-68867: Assembly of the pre-replicative complex R-HSA-69298: Association of licensing factors with the pre-replicative complex R-HSA-68689: CDC6 association with the ORC R-HSA-68827: CDT1 association with the CDC6 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-69306: DNA Replication R-HSA-69002: DNA Replication Pre-Initiation R-HSA-113510: E2F mediated regulation of DNA replication R-HSA-113507: E2F-enabled inhibition of pre-replication complex formation R-HSA-69206: G1/S Transition R-HSA-69205: G1/S-Specific Transcription R-HSA-69481: G2/M Checkpoints R-HSA-68874: M/G1 Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-68949: Orc1 removal from chromatin R-HSA-69304: Regulation of DNA replication R-HSA-69300: Removal of licensing factors from origins R-HSA-69242: S Phase R-HSA-69052: Switching of origins to a post-replicative state R-HSA-69239: Synthesis of DNA

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04110 Cell cycle

Reactome

R-HSA-176187: Activation of ATR in response to replication stress
R-HSA-68962: Activation of the pre-replicative complex
R-HSA-68616: Assembly of the ORC complex at the origin of replication
R-HSA-68867: Assembly of the pre-replicative complex
R-HSA-69298: Association of licensing factors with the pre-replicative complex
R-HSA-68689: CDC6 association with the ORC
R-HSA-68827: CDT1 association with the CDC6
R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-69306: DNA Replication
R-HSA-69002: DNA Replication Pre-Initiation
R-HSA-113510: E2F mediated regulation of DNA replication
R-HSA-113507: E2F-enabled inhibition of pre-replication complex formation
R-HSA-69206: G1/S Transition
R-HSA-69205: G1/S-Specific Transcription
R-HSA-69481: G2/M Checkpoints
R-HSA-68874: M/G1 Transition
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-68949: Orc1 removal from chromatin
R-HSA-69304: Regulation of DNA replication
R-HSA-69300: Removal of licensing factors from origins
R-HSA-69242: S Phase
R-HSA-69052: Switching of origins to a post-replicative state
R-HSA-69239: Synthesis of DNA

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3490662	c.1399C>T	p.P467S	Substitution - Missense	Skin
COSM4710322	c.253C>T	p.R85*	Substitution - Nonsense	Large_intestine
COSM4516587	c.2072_2073GG>AA	p.R691K	Substitution - Missense	Skin
COSM3490661	c.1515C>T	p.P505P	Substitution - coding silent	Skin
COSM4975985	c.924G>C	p.K308N	Substitution - Missense	Oesophagus
COSM5812351	c.1925A>T	p.H642L	Substitution - Missense	Liver
COSM219977	c.2360G>A	p.R787Q	Substitution - Missense	Prostate
COSM2192899	c.649T>C	p.S217P	Substitution - Missense	Large_intestine
COSM1218899	c.1822C>T	p.R608*	Substitution - Nonsense	Large_intestine
COSM464743	c.1476A>T	p.R492R	Substitution - coding silent	Kidney
COSM4797694	c.605G>A	p.W202*	Substitution - Nonsense	Liver
COSM1737358	c.437C>T	p.T146M	Substitution - Missense	Central_nervous_system
COSM1602532	c.256G>C	p.V86L	Substitution - Missense	Liver
COSM1218897	c.269T>C	p.V90A	Substitution - Missense	Large_intestine
COSM1320998	c.2531G>A	p.R844Q	Substitution - Missense	Ovary
COSM2192866	c.2517C>T	p.N839N	Substitution - coding silent	Large_intestine
COSM5456469	c.1755+6C>T	p.?	Unknown	Large_intestine
COSM4144075	c.2400T>C	p.S800S	Substitution - coding silent	Thyroid
COSM910656	c.961C>T	p.R321*	Substitution - Nonsense	Skin
COSM1343379	c.354G>A	p.P118P	Substitution - coding silent	Large_intestine
COSM5962073	c.2308T>C	p.S770P	Substitution - Missense	Breast
COSM1218900	c.613G>A	p.A205T	Substitution - Missense	Large_intestine
COSM5821533	c.1187+1G>T	p.?	Unknown	Liver
COSM397115	c.144G>C	p.Q48H	Substitution - Missense	Lung
COSM5716863	c.396T>G	p.L132L	Substitution - coding silent	Skin
COSM291200	c.698C>A	p.A233D	Substitution - Missense	Large_intestine
COSM3985128	c.1866C>T	p.L622L	Substitution - coding silent	Kidney
COSM910652	c.1429C>T	p.R477*	Substitution - Nonsense	Endometrium
COSM681800	c.1319C>T	p.S440F	Substitution - Missense	Lung
COSM233026	c.433C>T	p.P145S	Substitution - Missense	Skin
COSM1637054	c.1781C>G	p.A594G	Substitution - Missense	Bone
COSM4456528	c.1012C>T	p.P338S	Substitution - Missense	Skin
COSM4623071	c.1604T>C	p.V535A	Substitution - Missense	Large_intestine
COSM3934775	c.216C>T	p.F72F	Substitution - coding silent	Oesophagus
COSM4710320	c.1110T>C	p.N370N	Substitution - coding silent	Large_intestine
COSM3360954	c.1957G>A	p.A653T	Substitution - Missense	Kidney
COSM4617574	c.608C>T	p.T203I	Substitution - Missense	Upper_aerodigestive_tract
COSM5716863	c.396T>G	p.L132L	Substitution - coding silent	Skin
COSM1197041	c.934C>T	p.P312S	Substitution - Missense	Lung
COSM464742	c.1769A>G	p.Q590R	Substitution - Missense	Kidney
COSM4008808	c.2422A>C	p.M808L	Substitution - Missense	Stomach
COSM910648	c.1863+2T>C	p.?	Unknown	Endometrium
COSM1738456	c.2324A>G	p.Q775R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4547465	c.423G>A	p.K141K	Substitution - coding silent	Skin
COSM4397587	c.1132C>T	p.R378C	Substitution - Missense	Skin
COSM459063	c.495C>T	p.F165F	Substitution - coding silent	Cervix
COSM5716863	c.396T>G	p.L132L	Substitution - coding silent	Skin
COSM910649	c.1656G>A	p.Q552Q	Substitution - coding silent	Endometrium
COSM910647	c.2030G>A	p.C677Y	Substitution - Missense	Endometrium
COSM125073	c.1552G>A	p.V518M	Substitution - Missense	Upper_aerodigestive_tract
COSM3360953	c.2100T>C	p.F700F	Substitution - coding silent	Kidney
COSM414859	c.224-1G>A	p.?	Unknown	Urinary_tract
COSM273061	c.1331G>A	p.R444Q	Substitution - Missense	Large_intestine
COSM4008812	c.790C>T	p.R264W	Substitution - Missense	Stomach
COSM5053580	c.2295G>A	p.T765T	Substitution - coding silent	Stomach
COSM681798	c.216C>A	p.F72L	Substitution - Missense	Lung
COSM5518162	c.567C>T	p.P189P	Substitution - coding silent	Biliary_tract
COSM1218899	c.1822C>T	p.R608*	Substitution - Nonsense	Stomach
COSM5969466	c.1506G>C	p.E502D	Substitution - Missense	Upper_aerodigestive_tract
COSM4144074	c.2402A>G	p.Q801R	Substitution - Missense	Thyroid
COSM4008814	c.434C>T	p.P145L	Substitution - Missense	Stomach
COSM910650	c.1496C>T	p.A499V	Substitution - Missense	Endometrium
COSM426440	c.712G>C	p.E238Q	Substitution - Missense	Breast
COSM681799	c.944G>A	p.R315H	Substitution - Missense	Lung
COSM4820382	c.1221G>A	p.E407E	Substitution - coding silent	Cervix
COSM910657	c.956G>T	p.R319I	Substitution - Missense	Endometrium
COSM3805543	c.1430G>A	p.R477Q	Substitution - Missense	Breast
COSM3790117	c.444G>A	p.L148L	Substitution - coding silent	Urinary_tract
COSM464741	c.1936C>T	p.R646W	Substitution - Missense	Large_intestine
COSM910653	c.1402C>T	p.R468C	Substitution - Missense	Endometrium
COSM4167694	c.1999G>A	p.V667M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1165525	c.1132C>A	p.R378S	Substitution - Missense	Large_intestine
COSM1343374	c.1364C>T	p.T455M	Substitution - Missense	Large_intestine
COSM5588542	c.1997G>T	p.R666L	Substitution - Missense	Skin
COSM267086	c.1669G>T	p.A557S	Substitution - Missense	Large_intestine
COSM5957235	c.289G>T	p.A97S	Substitution - Missense	Thyroid
COSM910656	c.961C>T	p.R321*	Substitution - Nonsense	Endometrium
COSM3490658	c.1920C>T	p.P640P	Substitution - coding silent	Skin
COSM3386229	c.2489G>A	p.R830H	Substitution - Missense	Pancreas
COSM3490663	c.1137C>T	p.I379I	Substitution - coding silent	Skin
COSM3934774	c.807G>A	p.S269S	Substitution - coding silent	Oesophagus
COSM4888664	c.2138C>A	p.A713E	Substitution - Missense	Upper_aerodigestive_tract
COSM3805542	c.1690C>G	p.Q564E	Substitution - Missense	Breast
COSM910658	c.943C>T	p.R315C	Substitution - Missense	Endometrium
COSM4008810	c.2111C>T	p.A704V	Substitution - Missense	Stomach
COSM1343375	c.1187+2T>C	p.?	Unknown	Large_intestine
COSM241017	c.2128A>G	p.R710G	Substitution - Missense	Prostate
COSM4825032	c.841G>C	p.D281H	Substitution - Missense	Cervix
COSM3751283	c.1115C>T	p.A372V	Substitution - Missense	Large_intestine
COSM369111	c.400C>T	p.R134W	Substitution - Missense	Lung
COSM4008809	c.2381C>T	p.T794M	Substitution - Missense	Stomach
COSM3805545	c.528G>T	p.L176F	Substitution - Missense	Breast
COSM2192883	c.1646G>A	p.R549H	Substitution - Missense	Large_intestine
COSM2192906	c.448A>C	p.N150H	Substitution - Missense	Large_intestine
COSM3490660	c.1596C>T	p.I532I	Substitution - coding silent	Skin
COSM1343373	c.1491T>A	p.V497V	Substitution - coding silent	Large_intestine
COSM5719123	c.1584G>T	p.G528G	Substitution - coding silent	Skin
COSM4559124	c.792G>A	p.R264R	Substitution - coding silent	Skin
COSM146512	c.1636G>C	p.E546Q	Substitution - Missense	Stomach
COSM5044088	c.2078G>A	p.R693Q	Substitution - Missense	Liver
COSM3805544	c.1107G>T	p.Q369H	Substitution - Missense	Breast
COSM1492066	c.2161C>T	p.R721W	Substitution - Missense	Kidney
COSM384697	c.1790C>T	p.A597V	Substitution - Missense	Lung
COSM3711660	c.208G>A	p.E70K	Substitution - Missense	Upper_aerodigestive_tract
COSM4819342	c.1704C>G	p.V568V	Substitution - coding silent	Cervix
COSM3386230	c.1265A>G	p.D422G	Substitution - Missense	Pancreas
COSM5462440	c.2023A>G	p.R675G	Substitution - Missense	Large_intestine
COSM673788	c.2470T>A	p.S824T	Substitution - Missense	Endometrium
COSM5353371	c.1864C>T	p.L622F	Substitution - Missense	Large_intestine
COSM4528327	c.1527G>A	p.Q509Q	Substitution - coding silent	Skin
COSM5962905	c.130G>A	p.E44K	Substitution - Missense	Breast
COSM3711660	c.208G>A	p.E70K	Substitution - Missense	Upper_aerodigestive_tract
COSM4144073	c.2405A>C	p.H802P	Substitution - Missense	Thyroid
COSM5431698	c.2292C>G	p.I764M	Substitution - Missense	Oesophagus
COSM4710321	c.429G>T	p.V143V	Substitution - coding silent	Large_intestine
COSM910659	c.522G>A	p.A174A	Substitution - coding silent	Endometrium
COSM5479523	c.1414C>G	p.P472A	Substitution - Missense	Large_intestine
COSM4617574	c.608C>T	p.T203I	Substitution - Missense	Large_intestine
COSM4165242	c.757T>A	p.C253S	Substitution - Missense	Kidney
COSM4008813	c.602C>T	p.S201F	Substitution - Missense	Stomach
COSM4135625	c.1684C>T	p.P562S	Substitution - Missense	Pancreas
COSM5005050	c.1998G>A	p.R666R	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5963750	c.1756-1G>A	p.?	Unknown	Breast
COSM3667697	c.808G>A	p.E270K	Substitution - Missense	Liver
COSM163194	c.1192C>G	p.L398V	Substitution - Missense	Breast
COSM2192909	c.377C>T	p.A126V	Substitution - Missense	Large_intestine
COSM1602532	c.256G>C	p.V86L	Substitution - Missense	Liver
COSM2192891	c.1266C>T	p.D422D	Substitution - coding silent	Large_intestine
COSM5430672	c.519_523delTGCGG	p.F173fs*4	Deletion - Frameshift	Oesophagus
COSM4808242	c.322G>A	p.G108S	Substitution - Missense	Pancreas
COSM4565775	c.2526_2527CC>TT	p.L843F	Substitution - Missense	Skin
COSM5483908	c.1560C>T	p.S520S	Substitution - coding silent	Large_intestine
COSM4772224	c.1475G>T	p.R492L	Substitution - Missense	Stomach
COSM1260672	c.1777A>G	p.T593A	Substitution - Missense	Oesophagus
COSM4755336	c.1006C>T	p.L336F	Substitution - Missense	Stomach
COSM4008807	c.2509A>G	p.S837G	Substitution - Missense	Stomach
COSM5812481	c.1253A>T	p.D418V	Substitution - Missense	Liver
COSM910655	c.1001G>T	p.R334I	Substitution - Missense	Endometrium
COSM4746225	c.917A>G	p.D306G	Substitution - Missense	Central_nervous_system
COSM5478839	c.1709G>T	p.G570V	Substitution - Missense	Large_intestine
COSM5381200	c.217G>A	p.E73K	Substitution - Missense	Skin
COSM3490659	c.1826G>A	p.G609E	Substitution - Missense	Skin
COSM1343372	c.1867G>A	p.D623N	Substitution - Missense	Large_intestine
COSM4936562	c.752C>A	p.T251N	Substitution - Missense	Liver
COSM1687684	c.58C>G	p.P20A	Substitution - Missense	Skin
COSM3934775	c.216C>T	p.F72F	Substitution - coding silent	Skin
COSM4400068	c.184A>C	p.N62H	Substitution - Missense	Skin
COSM369111	c.400C>T	p.R134W	Substitution - Missense	Large_intestine
COSM1218898	c.1553T>C	p.V518A	Substitution - Missense	Large_intestine
COSM72032	c.951C>G	p.I317M	Substitution - Missense	Ovary
COSM910654	c.1160C>A	p.T387N	Substitution - Missense	Endometrium
COSM4755337	c.982A>G	p.I328V	Substitution - Missense	Stomach
COSM4008811	c.1483C>T	p.L495L	Substitution - coding silent	Stomach
COSM338257	c.2086C>A	p.H696N	Substitution - Missense	Lung
COSM910651	c.1439C>A	p.A480D	Substitution - Missense	Endometrium
COSM4797694	c.605G>A	p.W202*	Substitution - Nonsense	Liver
COSM4144076	c.2399G>T	p.S800I	Substitution - Missense	Thyroid
COSM459064	c.509C>T	p.S170L	Substitution - Missense	Cervix
COSM5499565	c.1560C>A	p.S520R	Substitution - Missense	Biliary_tract
COSM2192910	c.365G>A	p.S122N	Substitution - Missense	Large_intestine
COSM2192895	c.886delA	p.T296fs*21	Deletion - Frameshift	Large_intestine
COSM3490657	c.2153A>G	p.D718G	Substitution - Missense	Skin
COSM3490664	c.451G>A	p.E151K	Substitution - Missense	Skin
COSM143462	c.1501_1502CC>TT	p.P501F	Substitution - Missense	Skin
COSM5621432	c.652G>A	p.A218T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4452210	c.1673A>G	p.N558S	Substitution - Missense	Skin
COSM5954288	c.353C>T	p.P118L	Substitution - Missense	Upper_aerodigestive_tract
COSM1197041	c.934C>T	p.P312S	Substitution - Missense	Lung
COSM5917331	c.863C>T	p.P288L	Substitution - Missense	Skin
COSM5699002	c.2380A>T	p.T794S	Substitution - Missense	Soft_tissue
COSM2192910	c.365G>A	p.S122N	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for ORC1.

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13415	203	T	Phosphothreonine	-	No	None detected
Q13415	252	S	Phosphoserine	-	No	None detected
Q13415	255	S	Phosphoserine	-	No	None detected
Q13415	273	S	Phosphoserine	-	No	None detected
Q13415	287	S	Phosphoserine	-	No	None detected
Q13415	326	K	N6-acetyllysine	-	No	None detected
Q13415	337	T	Phosphothreonine	-	No	None detected
Q13415	340	S	Phosphoserine	-	No	None detected
Q13415	417	S	Phosphoserine	-	No	None detected
Q13415	420	S	Phosphoserine	-	No	None detected
Q13415	478	S	Phosphoserine	-	No	None detected

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	0.538	3.401	2.713	4.44e-19	Over
BRCA	Breast invasive carcinoma	112	1100	-0.042	2.355	2.386	1.59e-63	Over
CESC	Cervical and endocervical cancers	3	306	-0.507	4.648	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.961	4.038	1.021	5.82e-15	Over
ESCA	Esophageal carcinoma	11	185	-0.779	3.746	3.807	5.3e-24	Over
GBM	Glioblastoma multiforme	5	166	-1.773	2.705	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	2.635	3.758	1.724	7.32e-30	Over
KIRC	Kidney renal clear cell carcinoma	72	534	-0.499	0.738	1.228	1.59e-18	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	-0.111	0.661	0.942	4.53e-06	Over
LAML	Acute Myeloid Leukemia	0	173	NA	4.888	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	-0.022	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-2.227	1.297	3.258	1.39e-38	Over
LUAD	Lung adenocarcinoma	59	517	-0.548	2.519	2.861	6.92e-48	Over
LUSC	Lung squamous cell carcinoma	51	501	-0.272	3.864	3.996	1.7e-120	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.219	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	0.757	1.215	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.537	-0.839	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	-0.559	-0.101	0.581	4.54e-05	Over
READ	Rectum adenocarcinoma	10	167	2.881	3.936	0.88	0.00353	Over
SARC	Sarcoma	2	263	0.372	2.936	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.296	3.192	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	2.14	3.499	2.39	2.05e-21	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.106	NA	NA	NA
THCA	Thyroid carcinoma	59	509	-1.076	-0.005	0.736	1.75e-07	Over
THYM	Thymoma	2	120	3.776	4.07	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-0.735	3.108	3.496	9.58e-61	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0.5
Adrenal gland	0.6
Appendix	4.9
Bone marrow	18
Breast	1.3
Cerebral cortex	0.6
Cervix, uterine	0.5
Colon	3.4
Duodenum	1.7
Endometrium	1
Epididymis	0.2
Esophagus	2.3
Fallopian tube	0.5
Gallbladder	0.7
Heart muscle	0
Kidney	0.5
Liver	0.3
Lung	0.7
Lymph node	8
Ovary	0.3
Pancreas	0
Parathyroid gland	0.6
Placenta	2.7
Prostate	0.5
Rectum	4.6
Salivary gland	0.1
Seminal vesicle	0.3
Skeletal muscle	0
Skin	2.4
Small intestine	2.6
Smooth muscle	1.3
Spleen	1.7
Stomach	1
Testis	6.9
Thyroid gland	0.4
Tonsil	7.2
Urinary bladder	1.5

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.24	1.1e-06	13.4	66.1	20.5	Neutral
BRCA	Breast invasive carcinoma	1075	0.34	1.38e-30	28.3	57.5	14.2	Neutral
CESC	Cervical and endocervical cancers	292	0.355	4.45e-10	5.5	63.7	30.8	Neutral
COAD	Colon adenocarcinoma	449	0.334	3.42e-13	26.1	69.9	4	Neutral
ESCA	Esophageal carcinoma	183	0.131	0.0778	28.4	57.9	13.7	Neutral
GBM	Glioblastoma multiforme	147	0.256	0.00174	6.1	78.2	15.6	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.187	1.99e-05	13.6	73.5	12.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.299	2.82e-12	13.9	83	3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.269	3.7e-06	12.8	85.8	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.093	0.233	0	97.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.451	4.73e-27	36.5	60.8	2.7	Loss
LIHC	Liver hepatocellular carcinoma	364	0.266	2.5e-07	26.6	62.6	10.7	Neutral
LUAD	Lung adenocarcinoma	512	0.175	7.16e-05	20.9	54.7	24.4	Neutral
LUSC	Lung squamous cell carcinoma	498	0.175	8.62e-05	36.5	48.4	15.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.366	5.77e-11	15.7	49.3	35	Gain
PAAD	Pancreatic adenocarcinoma	177	0.209	0.00521	24.3	70.6	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.392	2.53e-07	71.6	28.4	0	Loss
PRAD	Prostate adenocarcinoma	491	0.115	0.0111	11.2	88	0.8	Neutral
READ	Rectum adenocarcinoma	164	0.256	0.000941	32.3	63.4	4.3	Neutral
SARC	Sarcoma	255	0.476	7.91e-16	11.4	58.4	30.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.407	4.63e-16	16.6	62.1	21.3	Neutral
STAD	Stomach adenocarcinoma	413	0.137	0.00542	18.9	73.1	8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.386	1.06e-06	17.3	58.7	24	Neutral
THCA	Thyroid carcinoma	497	0.031	0.489	0.8	98.6	0.6	Neutral
THYM	Thymoma	119	0.163	0.0763	5.9	93.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.152	0.000423	5.6	84	10.4	Neutral

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.149	0.0021	17	408	-0.022	0.000262	NS/NA
BRCA	Breast invasive carcinoma	-0.108	0.00148	83	785	0	0.0391	NS/NA
CESC	Cervical and endocervical cancers	-0.099	0.081	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.141	0.0125	19	297	-0.012	0.073	NS/NA
ESCA	Esophageal carcinoma	-0.208	0.00374	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.271	0.0293	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.105	0.0141	20	522	-0.014	0.107	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.036	0.506	24	319	-0.009	0.0114	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.195	0.000751	23	275	-0.006	0.203	NS/NA
LAML	Acute Myeloid Leukemia	-0.17	0.0266	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.346	2.55e-16	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.265	4.8e-08	41	373	-0.092	2.63e-33	NS/NA
LUAD	Lung adenocarcinoma	-0.212	3.07e-06	21	456	-0.026	0.000127	NS/NA
LUSC	Lung squamous cell carcinoma	-0.244	1.75e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.1	0.81	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.033	0.659	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.171	0.0196	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.237	3.33e-08	35	498	-0.023	1.42e-08	NS/NA
READ	Rectum adenocarcinoma	-0.197	0.0482	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.321	1.18e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.086	0.0624	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.184	0.000361	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.215	0.00716	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.09	0.0331	50	509	-0.002	0.0493	NS/NA
THYM	Thymoma	-0.009	0.918	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.135	0.00358	34	431	-0.028	0.00028	NS/NA

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	1	Low
Breast	1	Low
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	1	Low
Endometrium	0	Not detected
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	1	Low
Liver	2	Medium
Lung	1	Low
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	3	High
Parathyroid gland	3	High
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	1	Low
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	1	Low
Vagina	2	Medium

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0413	Significant	24476821
BRCA	Breast invasive carcinoma	521	2.06e-56	Significant	23000897
COAD	Colon adenocarcinoma	149	0.142	NS	22810696
GBM	Glioblastoma multiforme	157	0.000177	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00227	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00733	Significant	26536169
LGG	Brain Lower Grade Glioma	513	4.15e-25	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.83e-20	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	2.29e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	4.51e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.34	NS	26544944
READ	Rectum adenocarcinoma	67	0.385	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0068	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.62e-16	Significant	25079317
THCA	Thyroid carcinoma	391	1.89e-11	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.02e-14	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.246	0.288	NS
BRCA	Breast invasive carcinoma	1079	1.141	0.552	NS
CESC	Cervical and endocervical cancers	291	0.586	0.103	NS
COAD	Colon adenocarcinoma	439	0.621	0.117	NS
ESCA	Esophageal carcinoma	184	1.193	0.6	NS
GBM	Glioblastoma multiforme	158	0.806	0.383	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.669	0.0501	NS
KIRC	Kidney renal clear cell carcinoma	531	1.832	0.00343	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	3.747	0.00116	Shorter
LAML	Acute Myeloid Leukemia	149	1.576	0.116	NS
LGG	Brain Lower Grade Glioma	511	3.763	5.47e-07	Shorter
LIHC	Liver hepatocellular carcinoma	365	2.04	0.00378	Shorter
LUAD	Lung adenocarcinoma	502	1.686	0.014	Shorter
LUSC	Lung squamous cell carcinoma	494	0.741	0.111	NS
OV	Ovarian serous cystadenocarcinoma	303	0.904	0.631	NS
PAAD	Pancreatic adenocarcinoma	177	2.534	0.00347	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	0.969	0.982	NS
PRAD	Prostate adenocarcinoma	497	3.019	0.315	NS
READ	Rectum adenocarcinoma	159	0.389	0.129	NS
SARC	Sarcoma	259	2.223	0.00779	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.824	0.00184	Shorter
STAD	Stomach adenocarcinoma	388	0.674	0.0802	NS
TGCT	Testicular Germ Cell Tumors	134	577026061.896	0.325	NS
THCA	Thyroid carcinoma	500	1.156	0.849	NS
THYM	Thymoma	119	0.132	0.0427	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.678	0.134	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.066	0.184	NS
BRCA	Breast invasive carcinoma	1071	0.033	0.285	NS
CESC	Cervical and endocervical cancers	167	0.032	0.682	NS
COAD	Colon adenocarcinoma	445	-0.15	0.00146	Lower
ESCA	Esophageal carcinoma	162	-0.041	0.601	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.003	0.945	NS
KIRC	Kidney renal clear cell carcinoma	531	0.148	0.000601	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.356	3.44e-09	Higher
LIHC	Liver hepatocellular carcinoma	347	0.175	0.00106	Higher
LUAD	Lung adenocarcinoma	507	0.174	8.41e-05	Higher
LUSC	Lung squamous cell carcinoma	497	0.021	0.644	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.11	0.0568	NS
PAAD	Pancreatic adenocarcinoma	176	0.109	0.15	NS
READ	Rectum adenocarcinoma	156	-0.097	0.228	NS
SKCM	Skin Cutaneous Melanoma	410	-0.094	0.0566	NS
STAD	Stomach adenocarcinoma	392	-0.046	0.364	NS
TGCT	Testicular Germ Cell Tumors	81	0.316	0.00412	Higher
THCA	Thyroid carcinoma	499	0.035	0.442	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.136	0.00233	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.024	0.693	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.238	7.24e-08	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.185	2.08e-05	Higher
LGG	Brain Lower Grade Glioma	514	0.388	6.47e-20	Higher
LIHC	Liver hepatocellular carcinoma	366	0.323	2.53e-10	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.068	0.242	NS
PAAD	Pancreatic adenocarcinoma	176	0.219	0.00357	Higher
STAD	Stomach adenocarcinoma	406	-0.101	0.0416	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.462	1.41e-29	Higher

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ORC1.

Summary
Symbol	ORC1
Name	origin recognition complex subunit 1
Aliases	HSORC1; PARC1; origin recognition complex, subunit 1, S. cerevisiae, homolog-like; origin recognition comple ......
Location	1p32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for ORC1.

> Interactions from Text Mining [ TOP ]
There is no record for ORC1.