CR2Cancer

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

Function

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Classification

Class	Modification	Substrate	Product	PubMed
Polycomb group (PcG) protein	#	#	#	21282530

> Gene Ontology [ TOP ]
Biological Process	-
Molecular Function	GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0031519 PcG protein complex GO:0035102 PRC1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome	-

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5657023	c.86T>C	p.V29A	Substitution - Missense	Soft_tissue
COSM1504169	c.270G>A	p.L90L	Substitution - coding silent	Large_intestine
COSM2059751	c.388C>G	p.P130A	Substitution - Missense	Large_intestine
COSM5698149	c.103A>C	p.T35P	Substitution - Missense	Soft_tissue
COSM2059758	c.297_299delGGA	p.E99delE	Deletion - In frame	Breast
COSM5698148	c.103A>C	p.T35P	Substitution - Missense	Soft_tissue
COSM914323	c.261_263delAGA	p.E89delE	Deletion - In frame	Endometrium
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4787506	c.763G>A	p.A255T	Substitution - Missense	Liver
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4787505	c.988G>A	p.A330T	Substitution - Missense	Liver
COSM683490	c.4G>C	p.E2Q	Substitution - Missense	Lung
COSM2059735	c.558-3C>T	p.?	Unknown	Skin
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM1296894	c.141T>G	p.P47P	Substitution - coding silent	Urinary_tract
COSM1675527	c.565C>T	p.R189*	Substitution - Nonsense	Large_intestine
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM2059748	c.459C>T	p.T153T	Substitution - coding silent	Large_intestine
COSM4912083	c.770T>C	p.L257P	Substitution - Missense	Liver
COSM3414650	c.715G>C	p.E239Q	Substitution - Missense	Large_intestine
COSM1675527	c.565C>T	p.R189*	Substitution - Nonsense	Large_intestine
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM5894926	c.178C>T	p.R60W	Substitution - Missense	Skin
COSM5901671	c.656G>A	p.R219K	Substitution - Missense	Skin
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM5692395	c.274G>A	p.E92K	Substitution - Missense	Soft_tissue
COSM3716374	c.721T>C	p.Y241H	Substitution - Missense	Prostate
COSM4573327	c.379G>A	p.E127K	Substitution - Missense	Bone
COSM4787506	c.763G>A	p.A255T	Substitution - Missense	Liver
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM3716373	c.946T>C	p.Y316H	Substitution - Missense	Prostate
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4712698	c.300C>A	p.D100E	Substitution - Missense	Large_intestine
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM1289304	c.96C>A	p.P32P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3786312	c.909G>T	p.Q303H	Substitution - Missense	Pancreas
COSM23379	c.877A>G	p.R293G	Substitution - Missense	Kidney
COSM4433520	c.945delG	p.Q315fs*5	Deletion - Frameshift	Oesophagus
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM401104	c.167G>T	p.C56F	Substitution - Missense	Lung
COSM5631241	c.414A>G	p.K138K	Substitution - coding silent	Oesophagus
COSM465212	c.77C>A	p.P26Q	Substitution - Missense	Kidney
COSM4011355	c.381G>C	p.E127D	Substitution - Missense	Stomach
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM5657024	c.86T>C	p.V29A	Substitution - Missense	Soft_tissue
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM5831383	c.68_69delTG	p.L23fs*19	Deletion - Frameshift	Breast
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM368494	c.912A>G	p.V304V	Substitution - coding silent	Lung
COSM465211	c.77C>A	p.P26Q	Substitution - Missense	Kidney
COSM683492	c.822G>C	p.K274N	Substitution - Missense	Lung
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM1474325	c.967C>G	p.R323G	Substitution - Missense	Breast
COSM4849890	c.574C>G	p.Q192E	Substitution - Missense	Cervix
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4712697	c.614-3_614-2insT	p.?	Unknown	Large_intestine
COSM5901670	c.881G>A	p.R294K	Substitution - Missense	Skin
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM5445985	c.69_70insCCGCCT	p.P28_V29insPP	Insertion - In frame	Thyroid
COSM5940064	c.772-8C>T	p.?	Unknown	Skin
COSM2059759	c.297_299delGGA	p.E99delE	Deletion - In frame	Breast
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM3731481	c.666T>C	p.P222P	Substitution - coding silent	Stomach
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM3414649	c.940G>C	p.E314Q	Substitution - Missense	Large_intestine
COSM1296893	c.141T>G	p.P47P	Substitution - coding silent	Urinary_tract
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM23379	c.877A>G	p.R293G	Substitution - Missense	Kidney
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM914322	c.261_263delAGA	p.E89delE	Deletion - In frame	Endometrium
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM2059734	c.783-3C>T	p.?	Unknown	Skin
COSM1261519	c.814T>C	p.L272L	Substitution - coding silent	Stomach
COSM5692396	c.274G>A	p.E92K	Substitution - Missense	Soft_tissue
COSM3978051	c.640G>C	p.E214Q	Substitution - Missense	Lung
COSM5691119	c.84delT	p.V29fs*73	Deletion - Frameshift	Soft_tissue
COSM1638428	c.614-3delT	p.?	Unknown	Stomach
COSM1675527	c.565C>T	p.R189*	Substitution - Nonsense	Large_intestine
COSM4626616	c.943C>T	p.Q315*	Substitution - Nonsense	Large_intestine
COSM2154707	c.553A>G	p.I185V	Substitution - Missense	Central_nervous_system
COSM2154706	c.553A>G	p.I185V	Substitution - Missense	Central_nervous_system
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4457525	c.1049C>G	p.T350S	Substitution - Missense	Skin
COSM4626617	c.718C>T	p.Q240*	Substitution - Nonsense	Large_intestine
COSM1289303	c.96C>A	p.P32P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5691118	c.84delT	p.V29fs*73	Deletion - Frameshift	Soft_tissue
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM2059749	c.459C>T	p.T153T	Substitution - coding silent	Large_intestine
COSM5691118	c.84delT	p.V29fs*73	Deletion - Frameshift	Soft_tissue
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM3786313	c.684G>T	p.Q228H	Substitution - Missense	Pancreas
COSM2059750	c.388C>G	p.P130A	Substitution - Missense	Large_intestine
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM683493	c.597G>C	p.K199N	Substitution - Missense	Lung
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM1504168	c.270G>A	p.L90L	Substitution - coding silent	Large_intestine
COSM236191	c.605T>C	p.L202P	Substitution - Missense	Autonomic_ganglia
COSM4457526	c.824C>G	p.T275S	Substitution - Missense	Skin
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM1675527	c.565C>T	p.R189*	Substitution - Nonsense	Large_intestine
COSM914319	c.361C>T	p.R121C	Substitution - Missense	Endometrium
COSM368495	c.687A>G	p.V229V	Substitution - coding silent	Lung
COSM5445986	c.69_70insCCGCCT	p.P28_V29insPP	Insertion - In frame	Thyroid
COSM294683	c.281A>C	p.E94A	Substitution - Missense	Large_intestine
COSM401105	c.167G>T	p.C56F	Substitution - Missense	Lung
COSM5657024	c.86T>C	p.V29A	Substitution - Missense	Skin
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Central_nervous_system
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM343389	c.761C>T	p.S254F	Substitution - Missense	Skin
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM914318	c.361C>T	p.R121C	Substitution - Missense	Endometrium
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4787505	c.988G>A	p.A330T	Substitution - Missense	Liver
COSM5691119	c.84delT	p.V29fs*73	Deletion - Frameshift	Soft_tissue
COSM2154707	c.553A>G	p.I185V	Substitution - Missense	Central_nervous_system
COSM5657023	c.86T>C	p.V29A	Substitution - Missense	Soft_tissue
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Central_nervous_system
COSM5177983	c.782+6T>C	p.?	Unknown	Large_intestine
COSM343389	c.761C>T	p.S254F	Substitution - Missense	Lung
COSM343390	c.639C>G	p.F213L	Substitution - Missense	Lung
COSM5894925	c.178C>T	p.R60W	Substitution - Missense	Skin
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4712699	c.300C>A	p.D100E	Substitution - Missense	Large_intestine
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM5940063	c.997-8C>T	p.?	Unknown	Skin
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM3978050	c.865G>C	p.E289Q	Substitution - Missense	Lung
COSM1474326	c.742C>G	p.R248G	Substitution - Missense	Breast
COSM683491	c.4G>C	p.E2Q	Substitution - Missense	Lung
COSM3382654	c.478G>A	p.V160I	Substitution - Missense	Pancreas
COSM5631242	c.414A>G	p.K138K	Substitution - coding silent	Oesophagus
COSM914320	c.273G>T	p.E91D	Substitution - Missense	Endometrium
COSM2059758	c.297_299delGGA	p.E99delE	Deletion - In frame	Large_intestine
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM2059759	c.297_299delGGA	p.E99delE	Deletion - In frame	Large_intestine
COSM3382655	c.478G>A	p.V160I	Substitution - Missense	Pancreas
COSM23505	c.652A>G	p.R218G	Substitution - Missense	Kidney
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM2154706	c.553A>G	p.I185V	Substitution - Missense	Central_nervous_system
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4433521	c.720delG	p.Q240fs*5	Deletion - Frameshift	Oesophagus
COSM4011356	c.381G>C	p.E127D	Substitution - Missense	Stomach
COSM1560994	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM4573326	c.379G>A	p.E127K	Substitution - Missense	Bone
COSM3433842	c.736C>T	p.R246C	Substitution - Missense	Skin
COSM294684	c.281A>C	p.E94A	Substitution - Missense	Large_intestine
COSM5894925	c.178C>T	p.R60W	Substitution - Missense	Skin
COSM4603246	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM4603245	c.84_85insGCCTCC	p.P28_V29insAS	Insertion - In frame	Upper_aerodigestive_tract
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM5657024	c.86T>C	p.V29A	Substitution - Missense	Soft_tissue
COSM5657023	c.86T>C	p.V29A	Substitution - Missense	Skin
COSM5831382	c.68_69delTG	p.L23fs*19	Deletion - Frameshift	Breast
COSM2059737	c.674C>T	p.A225V	Substitution - Missense	Bone
COSM1560993	c.83_84insGCCTCC	p.P28_V29insPP	Insertion - In frame	Large_intestine
COSM914321	c.273G>T	p.E91D	Substitution - Missense	Endometrium
COSM1675527	c.565C>T	p.R189*	Substitution - Nonsense	Large_intestine
COSM5894926	c.178C>T	p.R60W	Substitution - Missense	Skin
COSM1261520	c.589T>C	p.L197L	Substitution - coding silent	Stomach

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27625789	Mutation	Metastatic Malignant Neoplasm in the Breast	We identify driver mutations in ADPGK, NUP93, PCGF6, PKP2 and SLC22A5, which are verified to enhance cancer cell migration and prompt metastasis with in vitro experiments.

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9BYE7	115	S	Phosphoserine	-	No	None detected

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.105	3.239	0.152	0.35	NS
BRCA	Breast invasive carcinoma	112	1100	3.243	3.117	-0.136	0.0126	NS
CESC	Cervical and endocervical cancers	3	306	3.606	3.644	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.743	3.125	0.271	0.0135	NS
ESCA	Esophageal carcinoma	11	185	2.455	2.981	0.456	0.0128	NS
GBM	Glioblastoma multiforme	5	166	2.877	2.858	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	2.498	2.921	0.469	3.36e-08	NS
KIRC	Kidney renal clear cell carcinoma	72	534	2.736	2.871	0.144	0.0186	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	2.551	2.643	0.072	0.418	NS
LAML	Acute Myeloid Leukemia	0	173	NA	3.35	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.282	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.191	2.922	-0.283	0.00232	NS
LUAD	Lung adenocarcinoma	59	517	2.657	3.036	0.319	4.77e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	2.69	3.381	0.686	3.48e-16	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	2.605	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	2.821	2.805	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.828	2.701	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	2.838	2.746	-0.133	0.0573	NS
READ	Rectum adenocarcinoma	10	167	3.045	3.063	-0.273	0.237	NS
SARC	Sarcoma	2	263	3.163	3.28	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	2.786	2.692	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	2.459	2.91	0.285	0.00878	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.25	NA	NA	NA
THCA	Thyroid carcinoma	59	509	2.444	2.456	0.016	0.756	NS
THYM	Thymoma	2	120	3.431	3.268	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.423	3.152	-0.159	0.248	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	8.3
Adrenal gland	4.4
Appendix	7.1
Bone marrow	2.8
Breast	7
Cerebral cortex	6
Cervix, uterine	6.1
Colon	4.3
Duodenum	4.6
Endometrium	10.1
Epididymis	4.1
Esophagus	5
Fallopian tube	4.8
Gallbladder	6.8
Heart muscle	3.4
Kidney	4.8
Liver	5.9
Lung	4.9
Lymph node	6.5
Ovary	4
Pancreas	1.1
Parathyroid gland	8.3
Placenta	6.6
Prostate	6.7
Rectum	4.9
Salivary gland	1.2
Seminal vesicle	7.3
Skeletal muscle	3.1
Skin	4.9
Small intestine	4.6
Smooth muscle	11.1
Spleen	5.6
Stomach	2.9
Testis	16.2
Thyroid gland	5.2
Tonsil	4.8
Urinary bladder	5.9

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26001296	Underexpression	Acute Lymphoblastic Leukemia	Six genes whose expression in leukemic blasts was associated with prognosis were identified:three genes predicting poor prognosis (AK022211, FASTKD1 and STARD4) and three genes associated with a favorable outcome (CAMSAP1, PCGF6 and SH3RF3).; IndeedAK022211, FASTKD1andPCGF6are active in early precursors of hematopoietic cells (CD34 positive cells from cord blood and/or bone marrow), whileSTARD4 was found to be preferentially expressed in blood B-lymphocytes andSH3RF3in bone marrow neutrophils.

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.414	3.52e-18	41.3	51.5	7.2	Loss
BRCA	Breast invasive carcinoma	1075	0.379	4.73e-38	30.2	61.6	8.2	Neutral
CESC	Cervical and endocervical cancers	292	0.522	7.78e-22	30.5	63.4	6.2	Neutral
COAD	Colon adenocarcinoma	449	0.326	1.49e-12	23.8	72.6	3.6	Neutral
ESCA	Esophageal carcinoma	183	0.255	0.000491	33.9	50.8	15.3	Loss
GBM	Glioblastoma multiforme	147	0.563	1.14e-13	91.2	8.2	0.7	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.409	3.76e-22	25.1	67.9	7	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.439	3.38e-26	18.1	79.8	2.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.329	1.03e-08	6.6	91	2.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.136	0.0806	0.6	97.6	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.552	2.9e-42	23.4	76.2	0.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.574	2.98e-33	26.1	64.3	9.6	Neutral
LUAD	Lung adenocarcinoma	512	0.413	1.53e-22	28.3	56.8	14.8	Neutral
LUSC	Lung squamous cell carcinoma	498	0.446	9.68e-26	52.4	39.8	7.8	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.579	3.11e-28	44.7	39	16.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.312	2.31e-05	19.8	72.9	7.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.225	0.00401	1.2	90.7	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.498	4.21e-32	16.7	81.3	2	Neutral
READ	Rectum adenocarcinoma	164	0.323	2.44e-05	29.9	68.3	1.8	Neutral
SARC	Sarcoma	255	0.387	1.59e-10	50.6	42.7	6.7	Loss
SKCM	Skin Cutaneous Melanoma	367	0.474	5.36e-22	62.4	35.7	1.9	Loss
STAD	Stomach adenocarcinoma	413	0.461	3.88e-23	22.5	64.2	13.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.233	0.00408	44.7	48	7.3	Loss
THCA	Thyroid carcinoma	497	0.186	2.96e-05	1.4	98.2	0.4	Neutral
THYM	Thymoma	119	0.354	7.94e-05	3.4	95	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.415	8.63e-24	12.3	66.9	20.9	Neutral

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.229	2.01e-06	17	408	0.002	0.179	NS/NA
BRCA	Breast invasive carcinoma	-0.142	2.58e-05	83	785	0.001	0.0754	NS/NA
CESC	Cervical and endocervical cancers	-0.348	4.23e-10	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.195	0.000503	19	297	0.003	0.0111	NS/NA
ESCA	Esophageal carcinoma	-0.181	0.0117	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.379	0.00199	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.177	3.52e-05	20	522	-0.002	0.69	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.098	0.0697	24	319	0.001	0.238	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.121	0.0372	23	275	0.001	0.404	NS/NA
LAML	Acute Myeloid Leukemia	-0.173	0.0242	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.243	1.68e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.291	1.81e-09	41	373	-0.001	0.706	NS/NA
LUAD	Lung adenocarcinoma	-0.15	0.00102	21	456	-0.003	0.84	NS/NA
LUSC	Lung squamous cell carcinoma	-0.189	0.000217	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.733	0.0311	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.254	0.00054	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.041	0.573	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.259	1.59e-09	35	498	0	0.562	NS/NA
READ	Rectum adenocarcinoma	-0.183	0.0677	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.2	0.00114	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.359	9.11e-16	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.257	5.26e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.359	4.76e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.093	0.0285	50	509	-0.002	0.303	NS/NA
THYM	Thymoma	-0.261	0.00383	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.163	0.000415	34	431	0.014	0.892	NS/NA

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.877	NS	24476821
BRCA	Breast invasive carcinoma	521	8.59e-15	Significant	23000897
COAD	Colon adenocarcinoma	149	0.78	NS	22810696
GBM	Glioblastoma multiforme	157	0.000189	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0396	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.828	NS	26536169
LGG	Brain Lower Grade Glioma	513	5.93e-32	Significant	26824661
LUAD	Lung adenocarcinoma	230	2.54e-08	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.139	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000453	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.371	NS	26544944
READ	Rectum adenocarcinoma	67	0.395	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	1.39e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	8.36e-07	Significant	25079317
THCA	Thyroid carcinoma	391	0.0484	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.961	NS	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.894	0.592	NS
BRCA	Breast invasive carcinoma	1079	1.049	0.844	NS
CESC	Cervical and endocervical cancers	291	0.931	0.827	NS
COAD	Colon adenocarcinoma	439	1.216	0.493	NS
ESCA	Esophageal carcinoma	184	1.766	0.0616	NS
GBM	Glioblastoma multiforme	158	0.607	0.0539	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.96	0.834	NS
KIRC	Kidney renal clear cell carcinoma	531	1.723	0.00627	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	2.623	0.0161	Shorter
LAML	Acute Myeloid Leukemia	149	0.999	0.999	NS
LGG	Brain Lower Grade Glioma	511	0.229	2.47e-09	Longer
LIHC	Liver hepatocellular carcinoma	365	1.037	0.883	NS
LUAD	Lung adenocarcinoma	502	1.568	0.043	Shorter
LUSC	Lung squamous cell carcinoma	494	0.749	0.142	NS
OV	Ovarian serous cystadenocarcinoma	303	1.093	0.668	NS
PAAD	Pancreatic adenocarcinoma	177	1.318	0.343	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.506	0.571	NS
PRAD	Prostate adenocarcinoma	497	1.768	0.507	NS
READ	Rectum adenocarcinoma	159	0.489	0.172	NS
SARC	Sarcoma	259	1.204	0.538	NS
SKCM	Skin Cutaneous Melanoma	459	0.851	0.406	NS
STAD	Stomach adenocarcinoma	388	0.834	0.42	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	2.28	0.315	NS
THYM	Thymoma	119	0	0.0613	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.904	0.755	NS

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.076	0.125	NS
BRCA	Breast invasive carcinoma	1071	-0.043	0.159	NS
CESC	Cervical and endocervical cancers	167	-0.006	0.942	NS
COAD	Colon adenocarcinoma	445	-0.11	0.0205	Lower
ESCA	Esophageal carcinoma	162	0.075	0.342	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.041	0.387	NS
KIRC	Kidney renal clear cell carcinoma	531	0.131	0.00255	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.153	0.0136	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.11	0.0403	Lower
LUAD	Lung adenocarcinoma	507	0.123	0.00538	Higher
LUSC	Lung squamous cell carcinoma	497	0.072	0.108	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.013	0.818	NS
PAAD	Pancreatic adenocarcinoma	176	-0.022	0.773	NS
READ	Rectum adenocarcinoma	156	0.021	0.792	NS
SKCM	Skin Cutaneous Melanoma	410	-0.074	0.136	NS
STAD	Stomach adenocarcinoma	392	-0.011	0.823	NS
TGCT	Testicular Germ Cell Tumors	81	0.042	0.707	NS
THCA	Thyroid carcinoma	499	0.057	0.205	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.048	0.287	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.005	0.931	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.197	9.71e-06	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.098	0.0245	Higher
LGG	Brain Lower Grade Glioma	514	-0.131	0.00286	Lower
LIHC	Liver hepatocellular carcinoma	366	0.007	0.894	NS
OV	Ovarian serous cystadenocarcinoma	296	0.04	0.489	NS
PAAD	Pancreatic adenocarcinoma	176	0.028	0.713	NS
STAD	Stomach adenocarcinoma	406	0.083	0.0936	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.134	0.00188	Higher

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PCGF6.

Summary
Symbol	PCGF6
Name	polycomb group ring finger 6
Aliases	MBLR; RNF134; ring finger protein 134; Mel18 and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING fin ......
Location	10q24.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for PCGF6.