CR2Cancer

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02747 Proliferating cell nuclear antigen
PF00705 Proliferating cell nuclear antigen

Function

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	H2A, H2B	#	12786946

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000302 response to reactive oxygen species GO:0000722 telomere maintenance via recombination GO:0000723 telomere maintenance GO:0000731 DNA synthesis involved in DNA repair GO:0001889 liver development GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006271 DNA strand elongation involved in DNA replication GO:0006272 leading strand elongation GO:0006275 regulation of DNA replication GO:0006282 regulation of DNA repair GO:0006283 transcription-coupled nucleotide-excision repair GO:0006289 nucleotide-excision repair GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006297 nucleotide-excision repair, DNA gap filling GO:0006298 mismatch repair GO:0006301 postreplication repair GO:0006310 DNA recombination GO:0006312 mitotic recombination GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006979 response to oxidative stress GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010948 negative regulation of cell cycle process GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019985 translesion synthesis GO:0022616 DNA strand elongation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031297 replication fork processing GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031960 response to corticosteroid GO:0032069 regulation of nuclease activity GO:0032070 regulation of deoxyribonuclease activity GO:0032075 positive regulation of nuclease activity GO:0032077 positive regulation of deoxyribonuclease activity GO:0032200 telomere organization GO:0032201 telomere maintenance via semi-conservative replication GO:0032355 response to estradiol GO:0033260 nuclear DNA replication GO:0033683 nucleotide-excision repair, DNA incision GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0034644 cellular response to UV GO:0042276 error-prone translesion synthesis GO:0042542 response to hydrogen peroxide GO:0042698 ovulation cycle GO:0042769 DNA damage response, detection of DNA damage GO:0042770 signal transduction in response to DNA damage GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044786 cell cycle DNA replication GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0044849 estrous cycle GO:0045005 DNA-dependent DNA replication maintenance of fidelity GO:0045739 positive regulation of DNA repair GO:0045740 positive regulation of DNA replication GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046686 response to cadmium ion GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048732 gland development GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051384 response to glucocorticoid GO:0060249 anatomical structure homeostasis GO:0061008 hepaticobiliary system development GO:0070301 cellular response to hydrogen peroxide GO:0070987 error-free translesion synthesis GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0071548 response to dexamethasone GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0097421 liver regeneration GO:1901654 response to ketone GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902065 response to L-glutamate GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1902990 mitotic telomere maintenance via semi-conservative replication GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus
Molecular Function	GO:0000700 mismatch base pair DNA N-glycosylase activity GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity GO:0003682 chromatin binding GO:0003684 damaged DNA binding GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0019104 DNA N-glycosylase activity GO:0030331 estrogen receptor binding GO:0030337 DNA polymerase processivity factor activity GO:0030971 receptor tyrosine kinase binding GO:0030983 mismatched DNA binding GO:0032135 DNA insertion or deletion binding GO:0032139 dinucleotide insertion or deletion binding GO:0032404 mismatch repair complex binding GO:0032405 MutLalpha complex binding GO:0035035 histone acetyltransferase binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0051427 hormone receptor binding GO:0070182 DNA polymerase binding GO:1990782 protein tyrosine kinase binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0005657 replication fork GO:0005663 DNA replication factor C complex GO:0005813 centrosome GO:0030894 replisome GO:0032993 protein-DNA complex GO:0043596 nuclear replication fork GO:0043626 PCNA complex GO:0044454 nuclear chromosome part GO:0044796 DNA polymerase processivity factor complex GO:0070557 PCNA-p21 complex GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03030 DNA replication hsa03410 Base excision repair hsa03420 Nucleotide excision repair hsa03430 Mismatch repair hsa04110 Cell cycle hsa04530 Tight junction
Reactome	R-HSA-73884: Base Excision Repair R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-73886: Chromosome Maintenance R-HSA-73893: DNA Damage Bypass R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69306: DNA Replication R-HSA-69190: DNA strand elongation R-HSA-5696400: Dual Incision in GG-NER R-HSA-6782135: Dual incision in TC-NER R-HSA-113510: E2F mediated regulation of DNA replication R-HSA-180786: Extension of Telomeres R-HSA-1538133: G0 and Early G1 R-HSA-69206: G1/S Transition R-HSA-69205: G1/S-Specific Transcription R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685942: HDR through Homologous Recombination (HRR) R-HSA-5693538: Homology Directed Repair R-HSA-69186: Lagging Strand Synthesis R-HSA-69109: Leading Strand Synthesis R-HSA-392499: Metabolism of proteins R-HSA-5358508: Mismatch Repair R-HSA-5358606: Mismatch repair (MMR) directed by MSH2 R-HSA-5358565: Mismatch repair (MMR) directed by MSH2 R-HSA-453279: Mitotic G1-G1/S phases R-HSA-5696398: Nucleotide Excision Repair R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair R-HSA-69091: Polymerase switching R-HSA-174411: Polymerase switching on the C-strand of the telomere R-HSA-597592: Post-translational protein modification R-HSA-174414: Processive synthesis on the C-strand of the telomere R-HSA-69183: Processive synthesis on the lagging strand R-HSA-110314: Recognition of DNA damage by PCNA-containing replication complex R-HSA-69166: Removal of the Flap Intermediate R-HSA-174437: Removal of the Flap Intermediate from the C-strand R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-69242: S Phase R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-4615885: SUMOylation of DNA replication proteins R-HSA-69239: Synthesis of DNA R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-174417: Telomere C-strand (Lagging Strand) Synthesis R-HSA-157579: Telomere Maintenance R-HSA-5656169: Termination of translesion DNA synthesis R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-110320: Translesion Synthesis by POLH R-HSA-5656121: Translesion synthesis by POLI R-HSA-5655862: Translesion synthesis by POLK R-HSA-110312: Translesion synthesis by REV1 R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

> KEGG and Reactome Pathway

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KEGG

hsa03030 DNA replication
hsa03410 Base excision repair
hsa03420 Nucleotide excision repair
hsa03430 Mismatch repair
hsa04110 Cell cycle
hsa04530 Tight junction

Reactome

R-HSA-73884: Base Excision Repair
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-73886: Chromosome Maintenance
R-HSA-73893: DNA Damage Bypass
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-69306: DNA Replication
R-HSA-69190: DNA strand elongation
R-HSA-5696400: Dual Incision in GG-NER
R-HSA-6782135: Dual incision in TC-NER
R-HSA-113510: E2F mediated regulation of DNA replication
R-HSA-180786: Extension of Telomeres
R-HSA-1538133: G0 and Early G1
R-HSA-69206: G1/S Transition
R-HSA-69205: G1/S-Specific Transcription
R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5685942: HDR through Homologous Recombination (HRR)
R-HSA-5693538: Homology Directed Repair
R-HSA-69186: Lagging Strand Synthesis
R-HSA-69109: Leading Strand Synthesis
R-HSA-392499: Metabolism of proteins
R-HSA-5358508: Mismatch Repair
R-HSA-5358606: Mismatch repair (MMR) directed by MSH2
R-HSA-5358565: Mismatch repair (MMR) directed by MSH2
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair
R-HSA-69091: Polymerase switching
R-HSA-174411: Polymerase switching on the C-strand of the telomere
R-HSA-597592: Post-translational protein modification
R-HSA-174414: Processive synthesis on the C-strand of the telomere
R-HSA-69183: Processive synthesis on the lagging strand
R-HSA-110314: Recognition of DNA damage by PCNA-containing replication complex
R-HSA-69166: Removal of the Flap Intermediate
R-HSA-174437: Removal of the Flap Intermediate from the C-strand
R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-69242: S Phase
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-4615885: SUMOylation of DNA replication proteins
R-HSA-69239: Synthesis of DNA
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-174417: Telomere C-strand (Lagging Strand) Synthesis
R-HSA-157579: Telomere Maintenance
R-HSA-5656169: Termination of translesion DNA synthesis
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-110320: Translesion Synthesis by POLH
R-HSA-5656121: Translesion synthesis by POLI
R-HSA-5655862: Translesion synthesis by POLK
R-HSA-110312: Translesion synthesis by REV1
R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM21734	c.262A>G	p.I88V	Substitution - Missense	Lung
COSM268237	c.581C>T	p.A194V	Substitution - Missense	Large_intestine
COSM5494612	c.287C>T	p.A96V	Substitution - Missense	Biliary_tract
COSM3547822	c.322C>T	p.Q108*	Substitution - Nonsense	Skin
COSM4099502	c.631T>C	p.Y211H	Substitution - Missense	Stomach
COSM4749134	c.5T>C	p.F2S	Substitution - Missense	Stomach
COSM4099503	c.226T>C	p.S76P	Substitution - Missense	Stomach
COSM1028116	c.109C>A	p.L37M	Substitution - Missense	Endometrium
COSM5464961	c.616A>G	p.T206A	Substitution - Missense	Large_intestine
COSM5821924	c.244G>T	p.A82S	Substitution - Missense	Liver
COSM1028113	c.738C>A	p.H246Q	Substitution - Missense	Endometrium
COSM1028115	c.327G>T	p.E109D	Substitution - Missense	Endometrium
COSM1028114	c.679C>A	p.L227I	Substitution - Missense	Endometrium
COSM3939407	c.629G>A	p.R210K	Substitution - Missense	Oesophagus
COSM4928755	c.678A>G	p.T226T	Substitution - coding silent	Liver
COSM6004489	c.579A>C	p.E193D	Substitution - Missense	Prostate
COSM4712855	c.754G>A	p.A252T	Substitution - Missense	Large_intestine
COSM355858	c.627G>T	p.L209L	Substitution - coding silent	Lung
COSM3799674	c.427G>A	p.E143K	Substitution - Missense	Urinary_tract
COSM283881	c.256G>T	p.D86Y	Substitution - Missense	Large_intestine
COSM257692	c.267A>C	p.T89T	Substitution - coding silent	Large_intestine
COSM5631501	c.155T>A	p.L52Q	Substitution - Missense	Oesophagus
COSM4634547	c.776A>G	p.E259G	Substitution - Missense	Large_intestine
COSM5638371	c.287C>G	p.A96G	Substitution - Missense	Oesophagus
COSM1028112	c.765C>T	p.I255I	Substitution - coding silent	Endometrium
COSM478303	c.358G>A	p.D120N	Substitution - Missense	Kidney
COSM4768885	c.613C>G	p.L205V	Substitution - Missense	Biliary_tract
COSM5183505	c.208G>A	p.V70M	Substitution - Missense	Large_intestine
COSM4712856	c.268C>A	p.L90I	Substitution - Missense	Large_intestine
COSM3363314	c.462T>G	p.I154M	Substitution - Missense	Kidney
COSM3740182	c.153C>T	p.T51T	Substitution - coding silent	Liver
COSM21734	c.262A>G	p.I88V	Substitution - Missense	Lung
COSM3363313	c.499G>C	p.V167L	Substitution - Missense	Kidney
COSM5621470	c.182G>A	p.R61H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3547824	c.216C>T	p.L72L	Substitution - coding silent	Skin
COSM4618043	c.400A>G	p.S134G	Substitution - Missense	Large_intestine
COSM3423731	c.731T>G	p.M244R	Substitution - Missense	Large_intestine
COSM4838327	c.574G>T	p.E192*	Substitution - Nonsense	Cervix
COSM1028117	c.54A>G	p.A18A	Substitution - coding silent	Endometrium
COSM3718881	c.291delT	p.D97fs*5	Deletion - Frameshift	Upper_aerodigestive_tract
COSM5777338	c.375A>C	p.Q125H	Substitution - Missense	Breast
COSM258903	c.506T>G	p.F169C	Substitution - Missense	Large_intestine
COSM3547823	c.310G>A	p.E104K	Substitution - Missense	Skin
COSM6004489	c.579A>C	p.E193D	Substitution - Missense	Prostate

> Text Mining based Variations [ TOP ]
There is no record for PCNA.

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P12004	77	K	N6-acetyllysine	-	No	None detected
P12004	80	K	N6-acetyllysine	-	No	None detected
P12004	211	Y	Phosphotyrosine	EGFR	Yes	p.Y211H (cancer: STAD)
P12004	248	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.694	7.374	1.454	5.1e-13	Over
BRCA	Breast invasive carcinoma	112	1100	5.615	6.919	1.313	7.13e-70	Over
CESC	Cervical and endocervical cancers	3	306	5.468	8.266	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.448	7.607	1.051	2.28e-18	Over
ESCA	Esophageal carcinoma	11	185	4.92	7.095	1.891	5.03e-13	Over
GBM	Glioblastoma multiforme	5	166	4.505	7.164	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.306	7.058	0.897	1.23e-14	Over
KIRC	Kidney renal clear cell carcinoma	72	534	5.671	5.883	0.169	0.00447	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.46	6.017	0.516	1.22e-07	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.125	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.683	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.892	5.844	0.962	5.96e-17	Over
LUAD	Lung adenocarcinoma	59	517	5.37	6.368	0.988	6.05e-21	Over
LUSC	Lung squamous cell carcinoma	51	501	5.484	7.332	1.865	8.16e-65	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.988	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.638	5.823	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.772	5.739	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.48	5.571	0.102	0.142	NS
READ	Rectum adenocarcinoma	10	167	6.603	7.551	0.806	0.00374	Over
SARC	Sarcoma	2	263	5.769	6.652	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.43	7.006	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.239	7.224	1.19	7.28e-14	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.624	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.576	6.047	0.41	4.18e-11	NS
THYM	Thymoma	2	120	7.497	7.984	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.484	6.888	1.342	7.67e-23	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12.8
Autonomic ganglia	CHP212	12.6
Autonomic ganglia	IMR32	12.8
Autonomic ganglia	KELLY	13.2
Autonomic ganglia	KPNRTBM1	13
Autonomic ganglia	KPNSI9S	12.3
Autonomic ganglia	KPNYN	13.4
Autonomic ganglia	MHHNB11	10.9
Autonomic ganglia	NB1	13.1
Autonomic ganglia	NH6	13.2
Autonomic ganglia	SHSY5Y	11.8
Autonomic ganglia	SIMA	12.7
Autonomic ganglia	SKNAS	11.8
Autonomic ganglia	SKNBE2	13
Autonomic ganglia	SKNDZ	13.3
Autonomic ganglia	SKNFI	12.5
Autonomic ganglia	SKNSH	12.7
Biliary tract	HUCCT1	12.9
Biliary tract	HUH28	12.7
Biliary tract	SNU1079	12.6
Biliary tract	SNU1196	13
Biliary tract	SNU245	12.4
Biliary tract	SNU308	11.9
Biliary tract	SNU478	12.4
Bone	143B	12.9
Bone	A673	13.2
Bone	CADOES1	12.3
Bone	CAL78	12.3
Bone	G292CLONEA141B1	12.8
Bone	HOS	13
Bone	HS706T	12.3
Bone	HS737T	11
Bone	HS819T	11
Bone	HS821T	11.9
Bone	HS822T	10.8
Bone	HS863T	11.9
Bone	HS870T	12.2
Bone	HS888T	11.8
Bone	MG63	12.7
Bone	MHHES1	11.7
Bone	OUMS27	12.5
Bone	RDES	12.6
Bone	SJSA1	12.7
Bone	SKES1	13.1
Bone	SKNMC	13
Bone	SW1353	11.8
Bone	T173	11.9
Bone	TC71	13.2
Bone	U2OS	12.7
Breast	AU565	12.4
Breast	BT20	12.5
Breast	BT474	12.9
Breast	BT483	12.6
Breast	BT549	12.7
Breast	CAL120	11.6
Breast	CAL148	13.3
Breast	CAL51	12.7
Breast	CAL851	13.1
Breast	CAMA1	12.8
Breast	DU4475	13.1
Breast	EFM192A	12.2
Breast	EFM19	13.2
Breast	EVSAT	12.6
Breast	HCC1143	12.6
Breast	HCC1187	13.2
Breast	HCC1395	12.6
Breast	HCC1419	12.2
Breast	HCC1428	11.5
Breast	HCC1500	12.1
Breast	HCC1569	12.9
Breast	HCC1599	12.2
Breast	HCC1806	12.2
Breast	HCC1937	13.1
Breast	HCC1954	12.8
Breast	HCC202	12.6
Breast	HCC2157	12.8
Breast	HCC2218	12.4
Breast	HCC38	13.3
Breast	HCC70	13
Breast	HDQP1	11.7
Breast	HMC18	11.9
Breast	HS274T	11.7
Breast	HS281T	11.7
Breast	HS343T	12.2
Breast	HS578T	11.2
Breast	HS606T	11.3
Breast	HS739T	11.5
Breast	HS742T	10.5
Breast	JIMT1	12.8
Breast	KPL1	12.3
Breast	MCF7	12.3
Breast	MDAMB134VI	12.1
Breast	MDAMB157	13
Breast	MDAMB175VII	12.7
Breast	MDAMB231	12.4
Breast	MDAMB361	12.2
Breast	MDAMB415	12.7
Breast	MDAMB436	11.8
Breast	MDAMB453	12.5
Breast	MDAMB468	13.2
Breast	SKBR3	12.7
Breast	T47D	12.8
Breast	UACC812	12
Breast	UACC893	12.1
Breast	YMB1	11.7
Breast	ZR751	12.2
Breast	ZR7530	13
Central nervous system	1321N1	12.6
Central nervous system	42MGBA	12.7
Central nervous system	8MGBA	12.4
Central nervous system	A172	12.7
Central nervous system	AM38	13
Central nervous system	BECKER	12.8
Central nervous system	CAS1	12.2
Central nervous system	CCFSTTG1	13.2
Central nervous system	D283MED	12.5
Central nervous system	D341MED	11.4
Central nervous system	DAOY	12.9
Central nervous system	DBTRG05MG	12.8
Central nervous system	DKMG	11.9
Central nervous system	GAMG	12.9
Central nervous system	GB1	13.3
Central nervous system	GI1	12.8
Central nervous system	GMS10	13.2
Central nervous system	GOS3	12.4
Central nervous system	H4	12.1
Central nervous system	HS683	12.5
Central nervous system	KALS1	12.2
Central nervous system	KG1C	12.7
Central nervous system	KNS42	12.4
Central nervous system	KNS60	12.6
Central nervous system	KNS81	12.6
Central nervous system	KS1	12.5
Central nervous system	LN18	12.7
Central nervous system	LN229	13.3
Central nervous system	M059K	12.4
Central nervous system	MOGGCCM	12.7
Central nervous system	MOGGUVW	12.4
Central nervous system	NMCG1	13.1
Central nervous system	ONS76	12.8
Central nervous system	SF126	12.6
Central nervous system	SF295	12.4
Central nervous system	SNB19	13.1
Central nervous system	SNU1105	11.8
Central nervous system	SNU201	11.8
Central nervous system	SNU466	11.7
Central nervous system	SNU489	11.6
Central nervous system	SNU626	13
Central nervous system	SNU738	12.4
Central nervous system	SW1088	12.9
Central nervous system	SW1783	12.7
Central nervous system	T98G	12.8
Central nervous system	TM31	12.4
Central nervous system	U118MG	12.9
Central nervous system	U138MG	11.8
Central nervous system	U251MG	12
Central nervous system	U87MG	11.7
Central nervous system	YH13	11.5
Central nervous system	YKG1	12.6
Endometrium	AN3CA	12.6
Endometrium	COLO684	13.8
Endometrium	EFE184	11.9
Endometrium	EN	12.5
Endometrium	ESS1	12.8
Endometrium	HEC108	12.7
Endometrium	HEC151	13.1
Endometrium	HEC1A	12.9
Endometrium	HEC1B	12.5
Endometrium	HEC251	12.3
Endometrium	HEC265	12.9
Endometrium	HEC50B	12.3
Endometrium	HEC59	11.8
Endometrium	HEC6	12.6
Endometrium	ISHIKAWAHERAKLIO02ER	12.2
Endometrium	JHUEM1	12
Endometrium	JHUEM2	12.9
Endometrium	JHUEM3	12
Endometrium	KLE	12.3
Endometrium	MFE280	12.2
Endometrium	MFE296	12.1
Endometrium	MFE319	12.3
Endometrium	RL952	12.4
Endometrium	SNGM	11.6
Endometrium	SNU1077	12
Endometrium	SNU685	12.1
Endometrium	TEN	13.1
Haematopoietic and lymphoid	697	13
Haematopoietic and lymphoid	A3KAW	12.7
Haematopoietic and lymphoid	A4FUK	12.9
Haematopoietic and lymphoid	ALLSIL	13.5
Haematopoietic and lymphoid	AML193	13
Haematopoietic and lymphoid	AMO1	13.1
Haematopoietic and lymphoid	BCP1	12.8
Haematopoietic and lymphoid	BDCM	13.1
Haematopoietic and lymphoid	BL41	13.2
Haematopoietic and lymphoid	BL70	13.5
Haematopoietic and lymphoid	BV173	12.8
Haematopoietic and lymphoid	CA46	11.1
Haematopoietic and lymphoid	CI1	13.4
Haematopoietic and lymphoid	CMK115	13.4
Haematopoietic and lymphoid	CMK86	13.6
Haematopoietic and lymphoid	CMK	13.1
Haematopoietic and lymphoid	CMLT1	12.8
Haematopoietic and lymphoid	COLO775	12.8
Haematopoietic and lymphoid	DAUDI	12.9
Haematopoietic and lymphoid	DB	13
Haematopoietic and lymphoid	DEL	11.7
Haematopoietic and lymphoid	DND41	13.3
Haematopoietic and lymphoid	DOHH2	13.1
Haematopoietic and lymphoid	EB1	11.5
Haematopoietic and lymphoid	EB2	11.4
Haematopoietic and lymphoid	EHEB	12.4
Haematopoietic and lymphoid	EJM	12.8
Haematopoietic and lymphoid	EM2	13.2
Haematopoietic and lymphoid	EOL1	12.9
Haematopoietic and lymphoid	F36P	12.5
Haematopoietic and lymphoid	GA10	13.4
Haematopoietic and lymphoid	GDM1	12.9
Haematopoietic and lymphoid	GRANTA519	12.4
Haematopoietic and lymphoid	HDLM2	12.2
Haematopoietic and lymphoid	HDMYZ	12.3
Haematopoietic and lymphoid	HEL9217	12.4
Haematopoietic and lymphoid	HEL	12
Haematopoietic and lymphoid	HH	12.9
Haematopoietic and lymphoid	HL60	12.7
Haematopoietic and lymphoid	HPBALL	13.1
Haematopoietic and lymphoid	HS604T	11.4
Haematopoietic and lymphoid	HS611T	13.4
Haematopoietic and lymphoid	HS616T	11.3
Haematopoietic and lymphoid	HS751T	11.9
Haematopoietic and lymphoid	HT	13
Haematopoietic and lymphoid	HTK	11.9
Haematopoietic and lymphoid	HUNS1	13.2
Haematopoietic and lymphoid	HUT102	13
Haematopoietic and lymphoid	HUT78	13.3
Haematopoietic and lymphoid	JEKO1	13.3
Haematopoietic and lymphoid	JK1	12.6
Haematopoietic and lymphoid	JM1	13.2
Haematopoietic and lymphoid	JURKAT	13
Haematopoietic and lymphoid	JURLMK1	12.6
Haematopoietic and lymphoid	JVM2	12.3
Haematopoietic and lymphoid	JVM3	12.7
Haematopoietic and lymphoid	K562	12.1
Haematopoietic and lymphoid	KARPAS299	11.8
Haematopoietic and lymphoid	KARPAS422	12.8
Haematopoietic and lymphoid	KARPAS620	12.3
Haematopoietic and lymphoid	KASUMI1	12.6
Haematopoietic and lymphoid	KASUMI2	13.1
Haematopoietic and lymphoid	KASUMI6	12.6
Haematopoietic and lymphoid	KCL22	12.7
Haematopoietic and lymphoid	KE37	13.4
Haematopoietic and lymphoid	KE97	13.2
Haematopoietic and lymphoid	KG1	13.1
Haematopoietic and lymphoid	KHM1B	12.9
Haematopoietic and lymphoid	KIJK	12.7
Haematopoietic and lymphoid	KMH2	12.7
Haematopoietic and lymphoid	KMM1	13
Haematopoietic and lymphoid	KMS11	12.4
Haematopoietic and lymphoid	KMS12BM	13.2
Haematopoietic and lymphoid	KMS18	12.9
Haematopoietic and lymphoid	KMS20	13.1
Haematopoietic and lymphoid	KMS21BM	12.4
Haematopoietic and lymphoid	KMS26	12.5
Haematopoietic and lymphoid	KMS27	12.9
Haematopoietic and lymphoid	KMS28BM	12.9
Haematopoietic and lymphoid	KMS34	12.5
Haematopoietic and lymphoid	KO52	12.8
Haematopoietic and lymphoid	KOPN8	13.4
Haematopoietic and lymphoid	KU812	12.8
Haematopoietic and lymphoid	KYO1	12.3
Haematopoietic and lymphoid	L1236	13
Haematopoietic and lymphoid	L363	12.6
Haematopoietic and lymphoid	L428	13.3
Haematopoietic and lymphoid	L540	13.1
Haematopoietic and lymphoid	LAMA84	12.5
Haematopoietic and lymphoid	LOUCY	13.2
Haematopoietic and lymphoid	LP1	10.2
Haematopoietic and lymphoid	M07E	13
Haematopoietic and lymphoid	MC116	13.4
Haematopoietic and lymphoid	ME1	12.8
Haematopoietic and lymphoid	MEC1	13.1
Haematopoietic and lymphoid	MEC2	13.1
Haematopoietic and lymphoid	MEG01	12.8
Haematopoietic and lymphoid	MHHCALL2	13.3
Haematopoietic and lymphoid	MHHCALL3	12.9
Haematopoietic and lymphoid	MHHCALL4	13.2
Haematopoietic and lymphoid	MINO	13.2
Haematopoietic and lymphoid	MJ	13.2
Haematopoietic and lymphoid	MM1S	13.1
Haematopoietic and lymphoid	MOLM13	13.2
Haematopoietic and lymphoid	MOLM16	12.9
Haematopoietic and lymphoid	MOLM6	12.4
Haematopoietic and lymphoid	MOLP2	11.5
Haematopoietic and lymphoid	MOLP8	11.3
Haematopoietic and lymphoid	MOLT13	13.4
Haematopoietic and lymphoid	MOLT16	12.9
Haematopoietic and lymphoid	MOLT4	13.4
Haematopoietic and lymphoid	MONOMAC1	12.6
Haematopoietic and lymphoid	MONOMAC6	12.9
Haematopoietic and lymphoid	MOTN1	12.9
Haematopoietic and lymphoid	MUTZ5	13.3
Haematopoietic and lymphoid	MV411	13.1
Haematopoietic and lymphoid	NALM19	13.3
Haematopoietic and lymphoid	NALM1	13.3
Haematopoietic and lymphoid	NALM6	13.4
Haematopoietic and lymphoid	NAMALWA	13
Haematopoietic and lymphoid	NB4	13.3
Haematopoietic and lymphoid	NCIH929	11.9
Haematopoietic and lymphoid	NCO2	13.1
Haematopoietic and lymphoid	NOMO1	12.7
Haematopoietic and lymphoid	NUDHL1	11.2
Haematopoietic and lymphoid	NUDUL1	13.1
Haematopoietic and lymphoid	OCIAML2	12.8
Haematopoietic and lymphoid	OCIAML3	12.2
Haematopoietic and lymphoid	OCIAML5	12.5
Haematopoietic and lymphoid	OCILY10	13.1
Haematopoietic and lymphoid	OCILY19	12.5
Haematopoietic and lymphoid	OCILY3	13.6
Haematopoietic and lymphoid	OCIM1	12.1
Haematopoietic and lymphoid	OPM2	12.4
Haematopoietic and lymphoid	P12ICHIKAWA	13.5
Haematopoietic and lymphoid	P31FUJ	13
Haematopoietic and lymphoid	P3HR1	13.3
Haematopoietic and lymphoid	PCM6	11.7
Haematopoietic and lymphoid	PEER	13.7
Haematopoietic and lymphoid	PF382	13.3
Haematopoietic and lymphoid	PFEIFFER	13
Haematopoietic and lymphoid	PL21	13.1
Haematopoietic and lymphoid	RAJI	13.3
Haematopoietic and lymphoid	RCHACV	13.3
Haematopoietic and lymphoid	REC1	12.4
Haematopoietic and lymphoid	REH	13.5
Haematopoietic and lymphoid	RI1	13.1
Haematopoietic and lymphoid	RL	13.4
Haematopoietic and lymphoid	RPMI8226	13.1
Haematopoietic and lymphoid	RPMI8402	12.9
Haematopoietic and lymphoid	RS411	13.1
Haematopoietic and lymphoid	SEM	13.1
Haematopoietic and lymphoid	SET2	12.3
Haematopoietic and lymphoid	SIGM5	13.3
Haematopoietic and lymphoid	SKM1	13.2
Haematopoietic and lymphoid	SKMM2	12.4
Haematopoietic and lymphoid	SR786	12.3
Haematopoietic and lymphoid	ST486	13.3
Haematopoietic and lymphoid	SUDHL10	13
Haematopoietic and lymphoid	SUDHL1	11.7
Haematopoietic and lymphoid	SUDHL4	12.6
Haematopoietic and lymphoid	SUDHL5	13.5
Haematopoietic and lymphoid	SUDHL6	13.2
Haematopoietic and lymphoid	SUDHL8	13.8
Haematopoietic and lymphoid	SUPB15	13.4
Haematopoietic and lymphoid	SUPHD1	12.2
Haematopoietic and lymphoid	SUPM2	12.4
Haematopoietic and lymphoid	SUPT11	13.2
Haematopoietic and lymphoid	SUPT1	13.2
Haematopoietic and lymphoid	TALL1	13.5
Haematopoietic and lymphoid	TF1	12.6
Haematopoietic and lymphoid	THP1	11.7
Haematopoietic and lymphoid	TO175T	12
Haematopoietic and lymphoid	TOLEDO	13.2
Haematopoietic and lymphoid	U266B1	12.5
Haematopoietic and lymphoid	U937	13.3
Haematopoietic and lymphoid	UT7	12.5
Haematopoietic and lymphoid	WSUDLCL2	13
Kidney	769P	12.7
Kidney	786O	12.3
Kidney	A498	12
Kidney	A704	12.5
Kidney	ACHN	12.8
Kidney	BFTC909	12.2
Kidney	CAKI1	11.5
Kidney	CAKI2	12.9
Kidney	CAL54	12.3
Kidney	KMRC1	12.6
Kidney	KMRC20	12.9
Kidney	KMRC2	12.8
Kidney	KMRC3	12.3
Kidney	OSRC2	13.3
Kidney	RCC10RGB	12.4
Kidney	SNU1272	12.4
Kidney	SNU349	12.2
Kidney	TUHR10TKB	13
Kidney	TUHR14TKB	12.3
Kidney	TUHR4TKB	12.8
Kidney	VMRCRCW	9.9
Kidney	VMRCRCZ	11.9
Large intestine	C2BBE1	12.7
Large intestine	CCK81	12.9
Large intestine	CL11	12.8
Large intestine	CL14	12.2
Large intestine	CL34	13.1
Large intestine	CL40	12.4
Large intestine	COLO205	13.5
Large intestine	COLO320	12.9
Large intestine	COLO678	12.9
Large intestine	CW2	13
Large intestine	DLD1	13.2
Large intestine	GP2D	12.6
Large intestine	HCC56	12.6
Large intestine	HCT116	13.1
Large intestine	HCT15	13.2
Large intestine	HS675T	12.1
Large intestine	HS698T	12.1
Large intestine	HT115	12.7
Large intestine	HT29	12.8
Large intestine	HT55	11.4
Large intestine	KM12	12.4
Large intestine	LOVO	13.1
Large intestine	LS1034	13.1
Large intestine	LS123	13.1
Large intestine	LS180	13
Large intestine	LS411N	12.6
Large intestine	LS513	12.8
Large intestine	MDST8	12.6
Large intestine	NCIH508	11.4
Large intestine	NCIH716	12.3
Large intestine	NCIH747	12.5
Large intestine	OUMS23	11.8
Large intestine	RCM1	11.8
Large intestine	RKO	12.9
Large intestine	SKCO1	12.2
Large intestine	SNU1040	12.8
Large intestine	SNU1197	12.7
Large intestine	SNU175	12.2
Large intestine	SNU283	13.2
Large intestine	SNU407	12.8
Large intestine	SNU503	11.9
Large intestine	SNU61	12.6
Large intestine	SNU81	11.9
Large intestine	SNUC1	12.8
Large intestine	SNUC2A	12.5
Large intestine	SNUC4	12.8
Large intestine	SNUC5	12.7
Large intestine	SW1116	12.1
Large intestine	SW1417	12.4
Large intestine	SW1463	12.9
Large intestine	SW403	13.5
Large intestine	SW480	13
Large intestine	SW48	12.7
Large intestine	SW620	13.4
Large intestine	SW837	11.6
Large intestine	SW948	12.5
Large intestine	T84	12.8
Liver	ALEXANDERCELLS	11.9
Liver	C3A	13.4
Liver	HEP3B217	12.5
Liver	HEPG2	12.8
Liver	HLE	13.3
Liver	HLF	13.3
Liver	HUH1	11.9
Liver	HUH6	13.2
Liver	HUH7	13.1
Liver	JHH1	12.7
Liver	JHH2	12
Liver	JHH4	13.1
Liver	JHH5	12.2
Liver	JHH6	12.3
Liver	JHH7	12.8
Liver	LI7	12.9
Liver	PLCPRF5	12.2
Liver	SKHEP1	12.4
Liver	SNU182	12.1
Liver	SNU387	13
Liver	SNU398	12.9
Liver	SNU423	12.6
Liver	SNU449	12.6
Liver	SNU475	12.6
Liver	SNU761	12.2
Liver	SNU878	12.7
Liver	SNU886	12.8
Lung	A549	12.9
Lung	ABC1	13.6
Lung	BEN	12
Lung	CAL12T	13.2
Lung	CALU1	13.1
Lung	CALU3	11.8
Lung	CALU6	12
Lung	CHAGOK1	12.9
Lung	COLO668	13.1
Lung	COLO699	11.7
Lung	CORL105	12.8
Lung	CORL23	12.5
Lung	CORL24	13.1
Lung	CORL279	13
Lung	CORL311	13.1
Lung	CORL47	13.3
Lung	CORL51	12.9
Lung	CORL88	13
Lung	CORL95	13
Lung	CPCN	13.4
Lung	DMS114	12.5
Lung	DMS153	13.1
Lung	DMS273	12.8
Lung	DMS454	13.3
Lung	DMS53	12.7
Lung	DMS79	13.2
Lung	DV90	13.1
Lung	EBC1	13.5
Lung	EPLC272H	12.7
Lung	HARA	12.9
Lung	HCC1171	11.8
Lung	HCC1195	12.1
Lung	HCC15	12.4
Lung	HCC2279	11.4
Lung	HCC2935	12.1
Lung	HCC33	13.2
Lung	HCC366	12.3
Lung	HCC4006	13.1
Lung	HCC44	12.3
Lung	HCC78	12.8
Lung	HCC827	12.3
Lung	HCC95	12.9
Lung	HLC1	11.8
Lung	HLFA	11.7
Lung	HS229T	12.7
Lung	HS618T	12.2
Lung	IALM	11.6
Lung	KNS62	12.4
Lung	LC1F	12.2
Lung	LC1SQSF	11.9
Lung	LCLC103H	11.4
Lung	LCLC97TM1	11.4
Lung	LK2	12.4
Lung	LOUNH91	11.8
Lung	LU65	13
Lung	LU99	13
Lung	LUDLU1	13.3
Lung	LXF289	11.2
Lung	MORCPR	12.7
Lung	NCIH1048	13.1
Lung	NCIH1092	12.8
Lung	NCIH1105	13.4
Lung	NCIH1155	13.4
Lung	NCIH1184	13.6
Lung	NCIH1299	12.6
Lung	NCIH1339	12.5
Lung	NCIH1341	12.8
Lung	NCIH1355	12.5
Lung	NCIH1373	11.8
Lung	NCIH1385	12.6
Lung	NCIH1395	11.8
Lung	NCIH1435	12.9
Lung	NCIH1436	12.7
Lung	NCIH1437	12
Lung	NCIH146	13.4
Lung	NCIH1563	12.5
Lung	NCIH1568	12.5
Lung	NCIH1573	11.1
Lung	NCIH1581	12.8
Lung	NCIH1618	13.3
Lung	NCIH1623	12.2
Lung	NCIH1648	12.6
Lung	NCIH1650	12.3
Lung	NCIH1651	12.2
Lung	NCIH1666	11.7
Lung	NCIH1693	12.1
Lung	NCIH1694	12.9
Lung	NCIH1703	12.6
Lung	NCIH1734	13.2
Lung	NCIH1755	13.3
Lung	NCIH1781	13
Lung	NCIH1792	12.2
Lung	NCIH1793	11.3
Lung	NCIH1836	13.6
Lung	NCIH1838	13.1
Lung	NCIH1869	11.7
Lung	NCIH1876	12.7
Lung	NCIH1915	12.5
Lung	NCIH1930	13.1
Lung	NCIH1944	12.7
Lung	NCIH1963	13.1
Lung	NCIH196	12.4
Lung	NCIH1975	12.8
Lung	NCIH2009	12.1
Lung	NCIH2023	12.8
Lung	NCIH2029	12.7
Lung	NCIH2030	11.5
Lung	NCIH2066	12.3
Lung	NCIH2081	12.6
Lung	NCIH2085	12.1
Lung	NCIH2087	11.9
Lung	NCIH209	12.9
Lung	NCIH2106	13.8
Lung	NCIH2110	12.6
Lung	NCIH211	12.8
Lung	NCIH2122	12.4
Lung	NCIH2126	11.9
Lung	NCIH2141	12.8
Lung	NCIH2170	13.1
Lung	NCIH2171	13
Lung	NCIH2172	12.1
Lung	NCIH2196	13
Lung	NCIH2227	13.2
Lung	NCIH2228	12.5
Lung	NCIH226	12
Lung	NCIH2286	12.4
Lung	NCIH2291	11.3
Lung	NCIH2342	11.4
Lung	NCIH2347	12.6
Lung	NCIH23	12.5
Lung	NCIH2405	12.8
Lung	NCIH2444	11.8
Lung	NCIH292	11.9
Lung	NCIH322	12.4
Lung	NCIH3255	12.4
Lung	NCIH358	13
Lung	NCIH441	11.5
Lung	NCIH446	12.7
Lung	NCIH460	13.1
Lung	NCIH510	13.1
Lung	NCIH520	12.5
Lung	NCIH522	12.1
Lung	NCIH524	13.3
Lung	NCIH526	13
Lung	NCIH596	11.9
Lung	NCIH647	11.8
Lung	NCIH650	11.3
Lung	NCIH661	12.2
Lung	NCIH69	13.7
Lung	NCIH727	12.8
Lung	NCIH810	12.7
Lung	NCIH82	12.9
Lung	NCIH838	13.1
Lung	NCIH841	12.2
Lung	NCIH854	12.5
Lung	NCIH889	13
Lung	PC14	12.7
Lung	RERFLCAD1	12.6
Lung	RERFLCAD2	13.2
Lung	RERFLCAI	12.6
Lung	RERFLCKJ	12.5
Lung	RERFLCMS	12
Lung	RERFLCSQ1	12.4
Lung	SBC5	11.4
Lung	SCLC21H	12.8
Lung	SHP77	13.3
Lung	SKLU1	12.4
Lung	SKMES1	11.7
Lung	SQ1	12.7
Lung	SW1271	12.3
Lung	SW1573	12.7
Lung	SW900	12.1
Lung	VMRCLCD	12.6
Lung	VMRCLCP	13.2
Oesophagus	COLO680N	12.1
Oesophagus	ECGI10	11.5
Oesophagus	KYSE140	12.5
Oesophagus	KYSE150	12.5
Oesophagus	KYSE180	12.4
Oesophagus	KYSE270	12.2
Oesophagus	KYSE30	11
Oesophagus	KYSE410	12.6
Oesophagus	KYSE450	12.3
Oesophagus	KYSE510	12.6
Oesophagus	KYSE520	12.8
Oesophagus	KYSE70	11.5
Oesophagus	OE19	12.7
Oesophagus	OE33	13.2
Oesophagus	TE10	12.1
Oesophagus	TE11	12.7
Oesophagus	TE14	12.6
Oesophagus	TE15	13.3
Oesophagus	TE1	12.7
Oesophagus	TE4	13
Oesophagus	TE5	12.5
Oesophagus	TE6	12.8
Oesophagus	TE8	12.2
Oesophagus	TE9	12.2
Oesophagus	TT	11.8
Ovary	59M	11.2
Ovary	A2780	12.9
Ovary	CAOV3	12.6
Ovary	CAOV4	12
Ovary	COLO704	13.4
Ovary	COV318	12.6
Ovary	COV362	12.3
Ovary	COV434	13.1
Ovary	COV504	12.4
Ovary	COV644	12.4
Ovary	EFO21	10.7
Ovary	EFO27	12.2
Ovary	ES2	12.6
Ovary	FUOV1	12.1
Ovary	HEYA8	12.2
Ovary	HS571T	11.4
Ovary	IGROV1	12.8
Ovary	JHOC5	12.7
Ovary	JHOM1	12
Ovary	JHOM2B	13.2
Ovary	JHOS2	12.7
Ovary	JHOS4	13.3
Ovary	KURAMOCHI	11.4
Ovary	MCAS	12.5
Ovary	NIHOVCAR3	11.6
Ovary	OAW28	12.7
Ovary	OAW42	12.6
Ovary	OC314	12.8
Ovary	OC316	13
Ovary	ONCODG1	11.6
Ovary	OV56	11
Ovary	OV7	12.4
Ovary	OV90	12.2
Ovary	OVCAR4	12.8
Ovary	OVCAR8	12.7
Ovary	OVISE	12.1
Ovary	OVK18	12.7
Ovary	OVKATE	12.4
Ovary	OVMANA	11.2
Ovary	OVSAHO	12.2
Ovary	OVTOKO	12.9
Ovary	RMGI	11.2
Ovary	RMUGS	12.5
Ovary	SKOV3	12.5
Ovary	SNU119	12.2
Ovary	SNU840	12.2
Ovary	SNU8	12.5
Ovary	TOV112D	13
Ovary	TOV21G	12.4
Ovary	TYKNU	12.5
Pancreas	ASPC1	11.3
Pancreas	BXPC3	13.2
Pancreas	CAPAN1	12.3
Pancreas	CAPAN2	12.8
Pancreas	CFPAC1	12
Pancreas	DANG	12.7
Pancreas	HPAC	11.7
Pancreas	HPAFII	12.6
Pancreas	HS766T	12.3
Pancreas	HUPT3	11.9
Pancreas	HUPT4	12.5
Pancreas	KCIMOH1	12.3
Pancreas	KLM1	12.6
Pancreas	KP2	13
Pancreas	KP3	11.6
Pancreas	KP4	12
Pancreas	L33	12.6
Pancreas	MIAPACA2	12.6
Pancreas	PANC0203	12.3
Pancreas	PANC0213	11.1
Pancreas	PANC0327	12.3
Pancreas	PANC0403	12.4
Pancreas	PANC0504	12.5
Pancreas	PANC0813	11.9
Pancreas	PANC1005	12.8
Pancreas	PANC1	12.7
Pancreas	PATU8902	13.4
Pancreas	PATU8988S	13.3
Pancreas	PATU8988T	12.9
Pancreas	PK1	13.3
Pancreas	PK45H	12.5
Pancreas	PK59	11.9
Pancreas	PL45	13.1
Pancreas	PSN1	13
Pancreas	QGP1	12.5
Pancreas	SNU213	12.6
Pancreas	SNU324	12
Pancreas	SNU410	11.3
Pancreas	SU8686	10.1
Pancreas	SUIT2	11.8
Pancreas	SW1990	13.1
Pancreas	T3M4	12
Pancreas	TCCPAN2	11.5
Pancreas	YAPC	12
Pleura	ACCMESO1	12.9
Pleura	DM3	11.1
Pleura	ISTMES1	12.7
Pleura	ISTMES2	12.5
Pleura	JL1	12.4
Pleura	MPP89	12.3
Pleura	MSTO211H	12.5
Pleura	NCIH2052	12.4
Pleura	NCIH2452	12.9
Pleura	NCIH28	12.7
Prostate	22RV1	13.3
Prostate	DU145	12.4
Prostate	LNCAPCLONEFGC	12.3
Prostate	MDAPCA2B	12.3
Prostate	NCIH660	13.6
Prostate	PC3	12.3
Prostate	VCAP	12.9
Salivary gland	A253	13
Salivary gland	YD15	13.1
Skin	A101D	12.3
Skin	A2058	12.5
Skin	A375	12.8
Skin	C32	13.1
Skin	CHL1	12.2
Skin	CJM	10
Skin	COLO679	12.2
Skin	COLO741	12.6
Skin	COLO783	12.2
Skin	COLO792	13.2
Skin	COLO800	12.4
Skin	COLO818	12.2
Skin	COLO829	12.2
Skin	COLO849	12.9
Skin	G361	13
Skin	GRM	13.5
Skin	HMCB	12.7
Skin	HS294T	11.9
Skin	HS600T	12.1
Skin	HS688AT	11.6
Skin	HS695T	12.6
Skin	HS839T	12.5
Skin	HS852T	12.8
Skin	HS895T	11.5
Skin	HS934T	11.9
Skin	HS936T	13.1
Skin	HS939T	13
Skin	HS940T	11.5
Skin	HS944T	12.7
Skin	HT144	12.4
Skin	IGR1	12.3
Skin	IGR37	13
Skin	IGR39	12.8
Skin	IPC298	12.4
Skin	K029AX	12.4
Skin	LOXIMVI	12.5
Skin	MALME3M	12.9
Skin	MDAMB435S	12.1
Skin	MELHO	13
Skin	MELJUSO	13
Skin	MEWO	12.1
Skin	RPMI7951	13
Skin	RVH421	12.2
Skin	SH4	12.9
Skin	SKMEL1	12.4
Skin	SKMEL24	12
Skin	SKMEL28	12.9
Skin	SKMEL2	12.9
Skin	SKMEL30	13.1
Skin	SKMEL31	12.8
Skin	SKMEL3	13.1
Skin	SKMEL5	12.9
Skin	UACC257	13.2
Skin	UACC62	12.3
Skin	WM115	12.2
Skin	WM1799	12.4
Skin	WM2664	12.9
Skin	WM793	11.9
Skin	WM88	12.9
Skin	WM983B	13.2
Small intestine	HUTU80	12.6
Soft tissue	A204	12.7
Soft tissue	G401	12.4
Soft tissue	G402	12.6
Soft tissue	GCT	12.5
Soft tissue	HS729	12.2
Soft tissue	HT1080	12.5
Soft tissue	KYM1	12.5
Soft tissue	MESSA	12.2
Soft tissue	RD	12.3
Soft tissue	RH30	12.7
Soft tissue	RH41	12.7
Soft tissue	RKN	11.9
Soft tissue	S117	12.5
Soft tissue	SJRH30	12.5
Soft tissue	SKLMS1	12.5
Soft tissue	SKUT1	13.1
Soft tissue	TE125T	11.4
Soft tissue	TE159T	11.7
Soft tissue	TE441T	12.9
Soft tissue	TE617T	12.8
Stomach	2313287	12.1
Stomach	AGS	13.3
Stomach	AZ521	12.7
Stomach	ECC10	13.4
Stomach	ECC12	12.6
Stomach	FU97	12.3
Stomach	GCIY	12.6
Stomach	GSS	12.1
Stomach	GSU	12.2
Stomach	HGC27	13.1
Stomach	HS746T	12.1
Stomach	HUG1N	13.2
Stomach	IM95	12.9
Stomach	KATOIII	13
Stomach	KE39	13.5
Stomach	LMSU	12.2
Stomach	MKN1	12.5
Stomach	MKN45	12.6
Stomach	MKN74	11.2
Stomach	MKN7	12.8
Stomach	NCCSTCK140	11.9
Stomach	NCIN87	12.7
Stomach	NUGC2	12.6
Stomach	NUGC3	12.8
Stomach	NUGC4	12
Stomach	OCUM1	12.5
Stomach	RERFGC1B	12
Stomach	SH10TC	12.8
Stomach	SNU16	12.9
Stomach	SNU1	13.4
Stomach	SNU216	12.8
Stomach	SNU520	12.9
Stomach	SNU5	12.4
Stomach	SNU601	12.6
Stomach	SNU620	12.9
Stomach	SNU668	13.1
Stomach	SNU719	13
Stomach	TGBC11TKB	11.9
Thyroid	8305C	12.8
Thyroid	8505C	13
Thyroid	BCPAP	11
Thyroid	BHT101	11
Thyroid	CAL62	13.1
Thyroid	CGTHW1	12.3
Thyroid	FTC133	12.1
Thyroid	FTC238	13.3
Thyroid	ML1	11.8
Thyroid	SW579	12.6
Thyroid	TT2609C02	12.6
Thyroid	TT	12.1
Upper aerodigestive tract	BHY	12.5
Upper aerodigestive tract	BICR16	12.4
Upper aerodigestive tract	BICR18	12.6
Upper aerodigestive tract	BICR22	11.2
Upper aerodigestive tract	BICR31	12
Upper aerodigestive tract	BICR56	9.8
Upper aerodigestive tract	BICR6	12.4
Upper aerodigestive tract	CAL27	12.3
Upper aerodigestive tract	CAL33	12.7
Upper aerodigestive tract	DETROIT562	12.2
Upper aerodigestive tract	FADU	12.2
Upper aerodigestive tract	HS840T	11.9
Upper aerodigestive tract	HSC2	12.4
Upper aerodigestive tract	HSC3	12.9
Upper aerodigestive tract	HSC4	12.8
Upper aerodigestive tract	PECAPJ15	12.6
Upper aerodigestive tract	PECAPJ34CLONEC12	12.4
Upper aerodigestive tract	PECAPJ41CLONED2	11.7
Upper aerodigestive tract	PECAPJ49	11.7
Upper aerodigestive tract	SCC15	11.7
Upper aerodigestive tract	SCC25	12.3
Upper aerodigestive tract	SCC4	11.7
Upper aerodigestive tract	SCC9	11.8
Upper aerodigestive tract	SNU1076	12.5
Upper aerodigestive tract	SNU1214	12.7
Upper aerodigestive tract	SNU46	11.4
Upper aerodigestive tract	SNU899	12.3
Upper aerodigestive tract	YD10B	12.7
Upper aerodigestive tract	YD38	12.1
Upper aerodigestive tract	YD8	11.4
Urinary tract	5637	12.5
Urinary tract	639V	13.2
Urinary tract	647V	13.1
Urinary tract	BC3C	12.9
Urinary tract	BFTC905	12.4
Urinary tract	CAL29	13
Urinary tract	HS172T	11.8
Urinary tract	HT1197	13.5
Urinary tract	HT1376	13.2
Urinary tract	J82	11.9
Urinary tract	JMSU1	12.5
Urinary tract	KMBC2	13.1
Urinary tract	KU1919	11.9
Urinary tract	RT11284	12.8
Urinary tract	RT112	13.2
Urinary tract	RT4	13
Urinary tract	SCABER	12.6
Urinary tract	SW1710	12.5
Urinary tract	SW780	12.9
Urinary tract	T24	12.5
Urinary tract	TCCSUP	12.9
Urinary tract	UMUC1	12.8
Urinary tract	UMUC3	13.3
Urinary tract	VMCUB1	12.1

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	33.8
Adrenal gland	55.7
Appendix	111
Bone marrow	223.6
Breast	58.4
Cerebral cortex	39.3
Cervix, uterine	59.2
Colon	82.9
Duodenum	69.3
Endometrium	60.3
Epididymis	34.6
Esophagus	71
Fallopian tube	58.7
Gallbladder	51.5
Heart muscle	19
Kidney	44
Liver	26.5
Lung	52.6
Lymph node	187.7
Ovary	44.1
Pancreas	6.5
Parathyroid gland	73.4
Placenta	93.7
Prostate	48.1
Rectum	98.9
Salivary gland	15
Seminal vesicle	50.4
Skeletal muscle	8.9
Skin	69.8
Small intestine	77.8
Smooth muscle	64
Spleen	58.6
Stomach	48.7
Testis	108.1
Thyroid gland	66.1
Tonsil	121.7
Urinary bladder	74.7

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
28704539	Overexpression	Colon Carcinoma	In addition, we observed increased level of β-catenin, c-Myc and PCNA in colon cancer cells following incubation with Sg.
28682441	Overexpression	Cervical Carcinoma	The levels of expression of p53, PCNA, and Ki-67 in the cervical cancer group were higher, while the levels of TIPE2 were lower compared with the other two groups (p < 0.05).
28611525	Overexpression	Gastric Carcinoma	The PCNA labeling index was significantly higher and the E-cadherin labeling index was significantly lower in gastric cancer than in dysplasia (P< 0.05). The expression of PCNA was significantly higher in the gastric cancer group than in the normal group, but E-cadherin was weaker (P< 0.05).
27651027	Overexpression	Ovarian Carcinoma	Expressions of TAB3 and PCNA (proliferating cell nuclear antigen) were found to be gradually increased in EOC tissues and cell lines, by western blot analysis and qRT-PCR.
26558632	altered expression	Cervical Carcinoma; Glioma Carcinoma	In the present study, the PCNA expression in cervical cancer and gliomas patients was both correlated with 5-year-overall survival (OS) (HR=4.41, 95% CI 2.71-7.17, p=0.000; HR=4.40, 95% CI 3.00-6.47, p=0.000; respectively).
27586268	Underexpression	Esophageal Squamous Cell Carcinoma	Western blotting and immunohistochemistry revealed the down-regulation of Bcl-2 and PCNA and the up-regulation of Bax and caspase-3 in tumor tissues.

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.448	2.2e-21	9.4	42.1	48.5	Gain
BRCA	Breast invasive carcinoma	1075	0.403	2.37e-43	12.7	51.6	35.6	Gain
CESC	Cervical and endocervical cancers	292	0.618	3.52e-32	8.9	56.5	34.6	Gain
COAD	Colon adenocarcinoma	449	0.638	9.97e-53	18.3	37	44.8	Gain
ESCA	Esophageal carcinoma	183	0.505	3.03e-13	14.2	31.7	54.1	Gain
GBM	Glioblastoma multiforme	147	0.328	5.07e-05	2.7	61.2	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.427	3.05e-24	10.9	53.3	35.8	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.346	3.19e-16	1.7	77	21.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.315	4.64e-08	1	64.9	34	Gain
LAML	Acute Myeloid Leukemia	166	0.095	0.222	0	99.4	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.373	2.49e-18	1.4	89.5	9.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.357	2.25e-12	7.7	63.2	29.1	Neutral
LUAD	Lung adenocarcinoma	512	0.492	1.4e-32	25.6	42.2	32.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.509	3.37e-34	9.2	36.7	54	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.429	7.51e-15	14.7	31.3	54	Gain
PAAD	Pancreatic adenocarcinoma	177	0.351	1.62e-06	13	70.6	16.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.421	2.38e-08	2.5	90.7	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.298	1.57e-11	6.1	88.8	5.1	Neutral
READ	Rectum adenocarcinoma	164	0.767	4.76e-33	29.9	22.6	47.6	Gain
SARC	Sarcoma	255	0.383	2.46e-10	27.5	49.8	22.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.456	3.11e-20	9	51.8	39.2	Gain
STAD	Stomach adenocarcinoma	413	0.502	1.06e-27	6.5	40.4	53	Gain
TGCT	Testicular Germ Cell Tumors	150	0.16	0.0499	23.3	54.7	22	Neutral
THCA	Thyroid carcinoma	497	0.131	0.00339	0	97.4	2.6	Neutral
THYM	Thymoma	119	-0.029	0.751	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.354	2.61e-17	4.8	73.4	21.8	Neutral

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.168	0.000514	17	408	-0.006	0.0147	NS/NA
BRCA	Breast invasive carcinoma	-0.202	2.04e-09	83	785	0	0.122	NS/NA
CESC	Cervical and endocervical cancers	-0.216	0.000138	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.247	9.31e-06	19	297	0.001	0.0949	NS/NA
ESCA	Esophageal carcinoma	-0.149	0.0385	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.42	0.000551	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.071	0.0979	20	522	0.001	0.295	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.177	0.00101	24	319	0.001	0.0136	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.191	0.000961	23	275	0	0.63	NS/NA
LAML	Acute Myeloid Leukemia	-0.169	0.0279	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.157	0.000283	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.189	0.00011	41	373	-0.002	0.556	NS/NA
LUAD	Lung adenocarcinoma	-0.228	4.91e-07	21	456	-0.008	0.102	NS/NA
LUSC	Lung squamous cell carcinoma	-0.242	2.15e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.85	0.00607	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.187	0.0112	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.133	0.069	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.17	8.04e-05	35	498	-0.003	0.000294	NS/NA
READ	Rectum adenocarcinoma	-0.65	0	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.18	0.00352	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.239	1.58e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.196	0.000152	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.365	3.2e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.129	0.00229	50	509	-0.001	0.043	NS/NA
THYM	Thymoma	-0.097	0.289	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.185	6.37e-05	34	431	-0.003	0.0493	NS/NA

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA)

[ TOP ]

Cancer	Full Name	# Sample	Median (abundance)	MAD (abundance)
BLCA	Bladder urothelial carcinoma	344	-0.068	0.227
BRCA	Breast invasive carcinoma	892	-0.011	0.193
CESC	Cervical and endocervical cancers	173	-0.042	0.179
COAD	Colon adenocarcinoma	362	-0.003	0.276
ESCA	Esophageal carcinoma	126	-0.051	0.205
GBM	Glioblastoma multiforme	244	-0.029	0.171
HNSC	Head and Neck squamous cell carcinoma	212	-0.072	0.217
KIRC	Kidney renal clear cell carcinoma	478	0.012	0.119
KIRP	Kidney renal papillary cell carcinoma	216	-0.001	0.135
LGG	Brain Lower Grade Glioma	435	-0.034	0.068
LIHC	Liver hepatocellular carcinoma	184	0.015	0.078
LUAD	Lung adenocarcinoma	365	0.017	0.152
LUSC	Lung squamous cell carcinoma	328	-0.034	0.212
OV	Ovarian serous cystadenocarcinoma	436	-0.029	0.196
PAAD	Pancreatic adenocarcinoma	123	-0.029	0.102
PCPG	Pheochromocytoma and Paraganglioma	82	0.104	0.098
PRAD	Prostate adenocarcinoma	352	0.016	0.097
READ	Rectum adenocarcinoma	131	-0.002	0.227
SARC	Sarcoma	226	0.062	0.174
SKCM	Skin Cutaneous Melanoma	355	-0.025	0.203
STAD	Stomach adenocarcinoma	357	0.011	0.255
TGCT	Testicular Germ Cell Tumors	122	-0.073	0.139
THCA	Thyroid carcinoma	224	1.053	0.136
THYM	Thymoma	90	0.074	0.298
UCEC	Uterine Corpus Endometrial Carcinoma	440	0.021	0.242

> The Human Protein Atlas (HPA)

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Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	0	Not detected
Cerebellum	1	Low
Cerebral cortex	0	Not detected
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	3	High
Nasopharynx	1	Low
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	1	Low
Parathyroid gland	1	Low
Placenta	1	Low
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	3	High
Smooth muscle	1	Low
Soft tissue	0	Not detected
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	0	Not detected
Vagina	2	Medium

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0496	Significant	24476821
BRCA	Breast invasive carcinoma	521	1e-36	Significant	23000897
COAD	Colon adenocarcinoma	149	0.264	NS	22810696
GBM	Glioblastoma multiforme	157	0.444	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000264	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.141	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.42e-12	Significant	26824661
LUAD	Lung adenocarcinoma	230	6.92e-12	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000131	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	6e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.794	NS	26544944
READ	Rectum adenocarcinoma	67	0.52	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.414	NS	26091043
STAD	Stomach adenocarcinoma	277	1.47e-18	Significant	25079317
THCA	Thyroid carcinoma	391	3.33e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.43e-08	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.863	0.516	NS
BRCA	Breast invasive carcinoma	1079	1.421	0.138	NS
CESC	Cervical and endocervical cancers	291	0.541	0.0485	Longer
COAD	Colon adenocarcinoma	439	0.727	0.279	NS
ESCA	Esophageal carcinoma	184	1.257	0.522	NS
GBM	Glioblastoma multiforme	158	1.006	0.981	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.724	0.117	NS
KIRC	Kidney renal clear cell carcinoma	531	1.156	0.496	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.397	0.0247	Shorter
LAML	Acute Myeloid Leukemia	149	1.352	0.289	NS
LGG	Brain Lower Grade Glioma	511	3.244	4.17e-06	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.935	0.00899	Shorter
LUAD	Lung adenocarcinoma	502	1.687	0.0157	Shorter
LUSC	Lung squamous cell carcinoma	494	0.865	0.431	NS
OV	Ovarian serous cystadenocarcinoma	303	0.761	0.191	NS
PAAD	Pancreatic adenocarcinoma	177	2.674	0.00195	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	2.627	0.389	NS
PRAD	Prostate adenocarcinoma	497	1.43	0.642	NS
READ	Rectum adenocarcinoma	159	0.08	0.00201	Longer
SARC	Sarcoma	259	1.617	0.0974	NS
SKCM	Skin Cutaneous Melanoma	459	1.244	0.25	NS
STAD	Stomach adenocarcinoma	388	0.69	0.118	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.124	0.0207	Longer
THYM	Thymoma	119	0	0.0363	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.625	0.133	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.059	0.238	NS
BRCA	Breast invasive carcinoma	1071	0.048	0.114	NS
CESC	Cervical and endocervical cancers	167	0.064	0.409	NS
COAD	Colon adenocarcinoma	445	-0.132	0.00546	Lower
ESCA	Esophageal carcinoma	162	0.057	0.473	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.02	0.666	NS
KIRC	Kidney renal clear cell carcinoma	531	0.163	0.000167	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.241	8.37e-05	Higher
LIHC	Liver hepatocellular carcinoma	347	0.189	0.000399	Higher
LUAD	Lung adenocarcinoma	507	0.061	0.169	NS
LUSC	Lung squamous cell carcinoma	497	0.118	0.00845	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.142	0.0137	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.079	0.298	NS
READ	Rectum adenocarcinoma	156	-0.05	0.538	NS
SKCM	Skin Cutaneous Melanoma	410	-0.095	0.0549	NS
STAD	Stomach adenocarcinoma	392	-0.078	0.124	NS
TGCT	Testicular Germ Cell Tumors	81	0.072	0.525	NS
THCA	Thyroid carcinoma	499	0.002	0.961	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.082	0.0659	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.024	0.693	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.193	1.46e-05	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.157	0.000294	Higher
LGG	Brain Lower Grade Glioma	514	0.353	1.63e-16	Higher
LIHC	Liver hepatocellular carcinoma	366	0.201	0.000106	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.033	0.567	NS
PAAD	Pancreatic adenocarcinoma	176	0.083	0.272	NS
STAD	Stomach adenocarcinoma	406	-0.058	0.242	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.355	2.92e-17	Higher

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PCNA.

Summary
Symbol	PCNA
Name	proliferating cell nuclear antigen
Aliases	ATLD2; DNA polymerase delta auxiliary protein; cyclin
Location	20p12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28611525	Gastric Carcinoma	partner	E-cadherin	Negative correlation	There was a negative correlation between the expression of PCNA and E-cadherin in gastric carcinoma (r = -0.741, P = 0.000).