Browse PHF24 in pancancer

Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF16744 KIAA1045 RING finger
Function

-

Classification
Class Modification Substrate Product PubMed
# # # # #
> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
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COSMIC ID
CDS change
AA change
Mutation Type
Anatomical Site
COSM753557c.305C>Ap.P102HSubstitution - MissenseLung
COSM1255649c.587C>Tp.T196ISubstitution - MissenseOesophagus
COSM266762c.261C>Tp.G87GSubstitution - coding silentLarge_intestine
COSM2773690c.106C>Tp.R36CSubstitution - MissensePancreas
COSM3779980c.88G>Cp.D30HSubstitution - MissenseUrinary_tract
COSM1108526c.9G>Ap.V3VSubstitution - coding silentEndometrium
COSM487409c.214A>Gp.S72GSubstitution - MissenseKidney
COSM4964393c.952C>Tp.R318WSubstitution - MissenseBreast
COSM120932c.698G>Ap.R233QSubstitution - MissenseUpper_aerodigestive_tract
COSM1489973c.967T>Cp.W323RSubstitution - MissenseBreast
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> Text Mining based Variations
 
There is no record for PHF24.
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
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Uniprot ID
Position
Amino Acid
Description
Upstream Enzyme
Amino Acid Sequence Variant
Q9UPV743SPhosphoserine-None detected
Q9UPV747TPhosphothreonine-None detected
Q9UPV751SPhosphoserine-None detected
Showing 1 to 3 of 3 rows
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
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Cancer
Full Name
# N
# T
Median (N)
Median (T)
LogFC
Adj. P
Status
BLCABladder urothelial carcinoma19408-1.06-2.94-1.7550.000493Under
BRCABreast invasive carcinoma11211000.656-1.949-2.4241.35e-35Under
CESCCervical and endocervical cancers33060.5-2.285NANANA
ESCAEsophageal carcinoma11185-1-0.849-0.1330.909NS
GBMGlioblastoma multiforme51668.4512.608NANANA
HNSCHead and Neck squamous cell carcinoma44522-0.8240.7881.5131.44e-06Over
KIRCKidney renal clear cell carcinoma72534-1.891-0.9820.7091.42e-05Over
KIRPKidney renal papillary cell carcinoma32291-1.293-1.88-0.4330.116NS
LGGBrain Lower Grade Glioma0530NA3.735NANANA
LUADLung adenocarcinoma59517-0.571-1.767-1.4247.31e-16Under
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> Cancer Cell Line Encyclopedia (CCLE)
 



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Tissue
Cell Line
Expression Level (Microarray)
Autonomic gangliaCHP1263.9
Autonomic gangliaCHP2123.7
Autonomic gangliaIMR323.9
Autonomic gangliaKELLY4
Autonomic gangliaKPNRTBM13.9
Autonomic gangliaKPNSI9S3.6
Autonomic gangliaKPNYN3.9
Autonomic gangliaMHHNB113.9
Autonomic gangliaNB13.9
Autonomic gangliaNH63.9
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> The Human Protein Atlas (HPA)
 


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Tissue
Expression Level (TPM)
Adipose tissue0.5
Adrenal gland0.3
Appendix0.6
Bone marrow0
Breast0.3
Cerebral cortex58.7
Cervix, uterine0.5
Colon0.1
Duodenum0.1
Endometrium0.5
Showing 1 to 10 of 37 rows rows per page
> Text Mining based Expression
 
There is no record.
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
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Cancer
Full Name
# Sample
R
P
% Loss
% Neutral
% Gain
Status
BLCABladder urothelial carcinoma4040.1210.015241.638.619.8Loss
BRCABreast invasive carcinoma10750.1831.51e-0925.457.916.7Neutral
CESCCervical and endocervical cancers2920.0870.13818.265.116.8Neutral
ESCAEsophageal carcinoma1830.1240.094848.631.120.2Loss
GBMGlioblastoma multiforme1470.2150.008933255.112.9Neutral
HNSCHead and Neck squamous cell carcinoma5140.2311.16e-0731.542.825.7Neutral
KIRCKidney renal clear cell carcinoma5250.0040.92127.469.72.9Neutral
KIRPKidney renal papillary cell carcinoma2880.0310.59711.187.51.4Neutral
LGGBrain Lower Grade Glioma5130.1250.004561680.53.5Neutral
LUADLung adenocarcinoma5120.0050.91742.443.214.5Loss
Showing 1 to 10 of 22 rows rows per page
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
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Cancer
Full Name
R
P
# N
# T
Delta beta (T vs N)
P value (T vs N)
Status
BLCABladder urothelial carcinoma-0.0450.3571740800.414NS/NA
BRCABreast invasive carcinoma-0.1563.74e-06837850.0040.319NS/NA
CESCCervical and endocervical cancers-0.1680.003163306NANANS/NA
ESCAEsophageal carcinoma-0.3652.07e-079185NANANS/NA
GBMGlioblastoma multiforme-0.3080.0129164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.0580.17620522-0.0010.15NS/NA
KIRCKidney renal clear cell carcinoma-0.130.016324319-0.0070.00206NS/NA
KIRPKidney renal papillary cell carcinoma-0.1040.0733232750.0220.143NS/NA
LGGBrain Lower Grade Glioma-0.3391.42e-150530NANANS/NA
LUADLung adenocarcinoma-0.050.278214560.0060.000185NS/NA
Showing 1 to 10 of 22 rows rows per page
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


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Tissue
Level
Level Name
Adrenal gland0Not detected
Appendix0Not detected
Bone marrow0Not detected
Breast0Not detected
Bronchus0Not detected
Caudate1Low
Cerebellum2Medium
Cerebral cortex3High
Cervix, uterine0Not detected
Colon0Not detected
Showing 1 to 10 of 44 rows rows per page
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
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Cancer
Full Name
# Patients
P Value (Kruskal-Wallis)
Association
Source
BLCABladder urothelial carcinoma1280.00469Significant24476821
BRCABreast invasive carcinoma5216.86e-31Significant23000897
GBMGlioblastoma multiforme1570.00131Significant26824661
HNSCHead and Neck squamous cell carcinoma2790.0391Significant25631445
KIRPKidney renal papillary cell carcinoma1610.00155Significant26536169
LGGBrain Lower Grade Glioma5130.00173Significant26824661
LUADLung adenocarcinoma2300.0605NS25079552
LUSCLung squamous cell carcinoma1780.0111Significant22960745
OVOvarian serous cystadenocarcinoma2874.31e-05Significant21720365
READRectum adenocarcinoma670.578NS22810696
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> Overall survival
 

  Overall survival analysis based on expression.
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Cancer
Full Name
# Patients
Hazard Ratio
P Value (Log Rank Test)
Association
BLCABladder urothelial carcinoma405 1.1750.461NS
BRCABreast invasive carcinoma1079 0.5780.0157Longer
CESCCervical and endocervical cancers291 0.9010.772NS
ESCAEsophageal carcinoma184 0.8180.551NS
GBMGlioblastoma multiforme158 1.3940.197NS
HNSCHead and Neck squamous cell carcinoma518 0.9890.952NS
KIRCKidney renal clear cell carcinoma531 1.4210.0896NS
KIRPKidney renal papillary cell carcinoma287 1.4320.353NS
LGGBrain Lower Grade Glioma511 0.6070.0647NS
LUADLung adenocarcinoma502 1.2130.342NS
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> Stage
 

  Association between expresson and stage.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
BLCABladder urothelial carcinoma406 0.1280.00996Higher
BRCABreast invasive carcinoma1071 -0.0810.00817Lower
CESCCervical and endocervical cancers167 -0.0190.81NS
ESCAEsophageal carcinoma162 0.0020.983NS
HNSCHead and Neck squamous cell carcinoma448 0.0020.959NS
KIRCKidney renal clear cell carcinoma531 0.0980.0241Higher
KIRPKidney renal papillary cell carcinoma260 0.190.00204Higher
LUADLung adenocarcinoma507 -0.0450.317NS
LUSCLung squamous cell carcinoma497 -0.0070.875NS
OVOvarian serous cystadenocarcinoma302 -0.0220.707NS
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> Grade
 

  Association between expresson and grade.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
CESCCervical and endocervical cancers272 -0.0040.949NS
HNSCHead and Neck squamous cell carcinoma498 -0.1680.000172Lower
KIRCKidney renal clear cell carcinoma525 0.1340.00208Higher
LGGBrain Lower Grade Glioma514 -0.1120.0113Lower
OVOvarian serous cystadenocarcinoma296 0.0390.499NS
PAADPancreatic adenocarcinoma176 -0.1740.0209Lower
STADStomach adenocarcinoma406 0.150.00242Higher
UCECUterine Corpus Endometrial Carcinoma534 0.1881.24e-05Higher
Showing 1 to 8 of 8 rows
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for PHF24.
Summary
SymbolPHF24
NamePHD finger protein 24
Aliases KIAA1045
Location9p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for PHF24.
> Interactions from Text Mining
 
There is no record for PHF24.