CR2Cancer

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02373 JmjC domain
PF00628 PHD-finger

Function

Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K9me1, H3K9me2, H3K27me2, H4K20me1, H3K36me2, H3K36me3, H3K4me3	H3K9, H3K27, H4K20, H3K36, H3K4	21423274

> Gene Ontology [ TOP ]
Biological Process	GO:0000082 G1/S transition of mitotic cell cycle GO:0000183 chromatin silencing at rDNA GO:0006342 chromatin silencing GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016577 histone demethylation GO:0031935 regulation of chromatin silencing GO:0031936 negative regulation of chromatin silencing GO:0033169 histone H3-K9 demethylation GO:0035574 histone H4-K20 demethylation GO:0040029 regulation of gene expression, epigenetic GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0045943 positive regulation of transcription from RNA polymerase I promoter GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0061187 regulation of chromatin silencing at rDNA GO:0061188 negative regulation of chromatin silencing at rDNA GO:0070076 histone lysine demethylation GO:0070544 histone H3-K36 demethylation GO:0070988 demethylation GO:0071557 histone H3-K27 demethylation GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0005506 iron ion binding GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032454 histone demethylase activity (H3-K9 specific) GO:0035064 methylated histone binding GO:0035575 histone demethylase activity (H4-K20 specific) GO:0042393 histone binding GO:0051213 dioxygenase activity GO:0051864 histone demethylase activity (H3-K36 specific) GO:0071558 histone demethylase activity (H3-K27 specific)
Cellular Component	GO:0005635 nuclear envelope GO:0031965 nuclear membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-2299718: Condensation of Prophase Chromosomes R-HSA-3214842: HDMs demethylate histones R-HSA-68886: M Phase R-HSA-68875: Mitotic Prophase

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1123273	c.1141G>C	p.G381R	Substitution - Missense	Endometrium
COSM3767009	c.1343T>C	p.V448A	Substitution - Missense	Liver
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Urinary_tract
COSM6018510	c.2996C>T	p.P999L	Substitution - Missense	Skin
COSM4794046	c.2247G>A	p.G749G	Substitution - coding silent	Liver
COSM488485	c.1708G>T	p.A570S	Substitution - Missense	Kidney
COSM1756622	c.1038C>A	p.A346A	Substitution - coding silent	Urinary_tract
COSM756871	c.1246C>T	p.H416Y	Substitution - Missense	Lung
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Stomach
COSM4887403	c.174G>T	p.G58G	Substitution - coding silent	Upper_aerodigestive_tract
COSM5412867	c.1176C>T	p.Y392Y	Substitution - coding silent	Skin
COSM488486	c.455-2A>G	p.?	Unknown	Kidney
COSM1315604	c.196C>T	p.R66C	Substitution - Missense	Urinary_tract
COSM3845083	c.1435A>G	p.M479V	Substitution - Missense	Breast
COSM5674741	c.398T>A	p.L133*	Substitution - Nonsense	Soft_tissue
COSM3708680	c.1280T>C	p.V427A	Substitution - Missense	Liver
COSM5064771	c.544G>A	p.G182R	Substitution - Missense	Stomach
COSM4714032	c.1727G>A	p.G576D	Substitution - Missense	Large_intestine
COSM457761	c.1141G>A	p.G381S	Substitution - Missense	Breast
COSM1123263	c.2845C>A	p.L949I	Substitution - Missense	Endometrium
COSM5588629	c.1602G>A	p.K534K	Substitution - coding silent	Skin
COSM4110260	c.30C>T	p.C10C	Substitution - coding silent	Stomach
COSM3845074	c.2934C>T	p.F978F	Substitution - coding silent	Breast
COSM457762	c.1003_1004delTT	p.L335fs*4	Deletion - Frameshift	Breast
COSM2968665	c.2730C>A	p.D910E	Substitution - Missense	Large_intestine
COSM326141	c.2020A>T	p.M674L	Substitution - Missense	Lung
COSM5412863	c.1658C>T	p.S553L	Substitution - Missense	Skin
COSM5501979	c.99-3C>T	p.?	Unknown	Biliary_tract
COSM1123266	c.2365G>A	p.E789K	Substitution - Missense	Endometrium
COSM5579312	c.2715G>A	p.Q905Q	Substitution - coding silent	Skin
COSM5757556	c.1906C>T	p.P636S	Substitution - Missense	Large_intestine
COSM5423009	c.1631A>G	p.N544S	Substitution - Missense	Prostate
COSM3562428	c.2204C>T	p.S735L	Substitution - Missense	Cervix
COSM4110209	c.2399A>G	p.D800G	Substitution - Missense	Stomach
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Large_intestine
COSM4154987	c.104T>A	p.V35D	Substitution - Missense	Kidney
COSM3786754	c.1352C>T	p.T451M	Substitution - Missense	Pancreas
COSM3562436	c.1739G>C	p.R580T	Substitution - Missense	Skin
COSM5946752	c.1133T>G	p.I378S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4794046	c.2247G>A	p.G749G	Substitution - coding silent	Liver
COSM3708676	c.2445C>G	p.I815M	Substitution - Missense	Liver
COSM3092507	c.1498C>A	p.L500I	Substitution - Missense	Upper_aerodigestive_tract
COSM3562446	c.1237C>T	p.L413L	Substitution - coding silent	Skin
COSM4942269	c.2306C>T	p.P769L	Substitution - Missense	Liver
COSM4714017	c.2964_2965delCC	p.Q989fs*>36	Deletion - Frameshift	Large_intestine
COSM5455901	c.294-10C>T	p.?	Unknown	Large_intestine
COSM5064764	c.1516C>T	p.R506*	Substitution - Nonsense	Stomach
COSM1123280	c.428C>T	p.T143I	Substitution - Missense	Endometrium
COSM1468629	c.1733C>T	p.T578M	Substitution - Missense	Large_intestine
COSM4110244	c.938T>C	p.I313T	Substitution - Missense	Stomach
COSM3379658	c.3026G>A	p.R1009K	Substitution - Missense	Pancreas
COSM4387350	c.1531A>G	p.S511G	Substitution - Missense	Lung
COSM4806557	c.2915C>T	p.P972L	Substitution - Missense	Pancreas
COSM4523658	c.1119G>A	p.K373K	Substitution - coding silent	Skin
COSM4110229	c.1607G>C	p.G536A	Substitution - Missense	Stomach
COSM3092559	c.936C>T	p.F312F	Substitution - coding silent	Skin
COSM211491	c.2444-1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3562418	c.3039C>T	p.I1013I	Substitution - coding silent	Skin
COSM1123277	c.809G>A	p.R270H	Substitution - Missense	Endometrium
COSM3372297	c.293+1G>T	p.?	Unknown	Thyroid
COSM3406485	c.820G>C	p.A274P	Substitution - Missense	Central_nervous_system
COSM5611559	c.339G>T	p.V113V	Substitution - coding silent	Adrenal_gland
COSM5588626	c.2869C>T	p.R957C	Substitution - Missense	Skin
COSM1123281	c.325A>C	p.N109H	Substitution - Missense	Endometrium
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Large_intestine
COSM219034	c.2011G>C	p.D671H	Substitution - Missense	Pancreas
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Large_intestine
COSM292328	c.1279G>A	p.V427I	Substitution - Missense	Large_intestine
COSM1220386	c.2318G>A	p.R773H	Substitution - Missense	Large_intestine
COSM1468627	c.2108delG	p.G703fs*126	Deletion - Frameshift	Large_intestine
COSM5911156	c.236C>G	p.P79R	Substitution - Missense	Skin
COSM3562424	c.2258G>A	p.R753Q	Substitution - Missense	Skin
COSM1625994	c.508A>G	p.M170V	Substitution - Missense	Liver
COSM4110252	c.491G>A	p.R164H	Substitution - Missense	Stomach
COSM1331783	c.455-20_455-1del20	p.?	Unknown	Ovary
COSM219034	c.2011G>C	p.D671H	Substitution - Missense	Pancreas
COSM3562463	c.261C>T	p.F87F	Substitution - coding silent	Skin
COSM4154983	c.660G>A	p.W220*	Substitution - Nonsense	Kidney
COSM1123261	c.3070C>A	p.L1024M	Substitution - Missense	Endometrium
COSM4806557	c.2915C>T	p.P972L	Substitution - Missense	Pancreas
COSM5658974	c.2308G>T	p.A770S	Substitution - Missense	Soft_tissue
COSM3845080	c.2074C>A	p.L692I	Substitution - Missense	Breast
COSM121545	c.2904C>T	p.R968R	Substitution - coding silent	Upper_aerodigestive_tract
COSM1220388	c.2667A>C	p.Q889H	Substitution - Missense	Large_intestine
COSM3767002	c.3005G>A	p.G1002D	Substitution - Missense	Liver
COSM3092498	c.1594G>A	p.A532T	Substitution - Missense	Large_intestine
COSM1491106	c.1148G>A	p.R383Q	Substitution - Missense	Breast
COSM1123262	c.2992C>T	p.R998C	Substitution - Missense	Endometrium
COSM6018513	c.2900A>G	p.N967S	Substitution - Missense	Skin
COSM3562463	c.261C>T	p.F87F	Substitution - coding silent	Skin
COSM257721	c.632G>A	p.R211Q	Substitution - Missense	Large_intestine
COSM3767005	c.1720T>A	p.S574T	Substitution - Missense	Liver
COSM5965578	c.1818G>T	p.V606V	Substitution - coding silent	Breast
COSM383647	c.376C>A	p.L126M	Substitution - Missense	Lung
COSM1123276	c.941C>A	p.P314H	Substitution - Missense	Endometrium
COSM1123264	c.2700G>A	p.L900L	Substitution - coding silent	Endometrium
COSM1123275	c.1029G>T	p.Q343H	Substitution - Missense	Endometrium
COSM4379724	c.210G>T	p.K70N	Substitution - Missense	Large_intestine
COSM4110206	c.2727A>T	p.Q909H	Substitution - Missense	Stomach
COSM4110256	c.445C>T	p.H149Y	Substitution - Missense	Stomach
COSM3562421	c.2801C>T	p.P934L	Substitution - Missense	Skin
COSM1756622	c.1038C>A	p.A346A	Substitution - coding silent	Urinary_tract
COSM5711711	c.2542C>T	p.R848C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3845086	c.882G>A	p.G294G	Substitution - coding silent	Breast
COSM1123268	c.2090C>T	p.A697V	Substitution - Missense	Endometrium
COSM3562459	c.289G>T	p.D97Y	Substitution - Missense	Skin
COSM4629618	c.756C>G	p.G252G	Substitution - coding silent	Large_intestine
COSM1123279	c.489C>A	p.T163T	Substitution - coding silent	Endometrium
COSM1123261	c.3070C>A	p.L1024M	Substitution - Missense	Endometrium
COSM3708680	c.1280T>C	p.V427A	Substitution - Missense	Liver
COSM1491099	c.2746A>T	p.T916S	Substitution - Missense	Breast
COSM3562443	c.1515G>A	p.E505E	Substitution - coding silent	Skin
COSM3562432	c.1828G>A	p.E610K	Substitution - Missense	Skin
COSM4514689	c.876C>T	p.F292F	Substitution - coding silent	Skin
COSM294699	c.1126C>A	p.L376M	Substitution - Missense	Large_intestine
COSM4825436	c.203C>T	p.S68F	Substitution - Missense	Cervix
COSM4912756	c.1317G>A	p.L439L	Substitution - coding silent	Liver
COSM4826262	c.1249G>A	p.E417K	Substitution - Missense	Cervix
COSM756872	c.2071A>G	p.I691V	Substitution - Missense	Lung
COSM3092571	c.353A>G	p.E118G	Substitution - Missense	Lung
COSM72169	c.1231G>A	p.E411K	Substitution - Missense	Ovary
COSM3379704	c.631C>T	p.R211*	Substitution - Nonsense	Pancreas
COSM1734872	c.2306C>A	p.P769H	Substitution - Missense	Pancreas
COSM1169364	c.281G>C	p.R94T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1472217	c.988T>G	p.F330V	Substitution - Missense	Prostate
COSM4714028	c.2226C>T	p.S742S	Substitution - coding silent	Large_intestine
COSM3940055	c.573T>C	p.I191I	Substitution - coding silent	Oesophagus
COSM139243	c.2576C>T	p.P859L	Substitution - Missense	Skin
COSM4461061	c.1083C>T	p.F361F	Substitution - coding silent	Skin
COSM1220389	c.2937G>C	p.L979F	Substitution - Missense	Large_intestine
COSM4881509	c.430G>T	p.V144L	Substitution - Missense	Upper_aerodigestive_tract
COSM4564348	c.1037_1038CC>TT	p.A346V	Substitution - Missense	Skin
COSM4956909	c.2715G>T	p.Q905H	Substitution - Missense	Liver
COSM3092531	c.1389C>T	p.A463A	Substitution - coding silent	Large_intestine
COSM1468632	c.1666G>T	p.D556Y	Substitution - Missense	Large_intestine
COSM115817	c.1732A>G	p.T578A	Substitution - Missense	Ovary
COSM4806557	c.2915C>T	p.P972L	Substitution - Missense	Pancreas
COSM3720038	c.1935G>A	p.A645A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1123274	c.1140C>T	p.R380R	Substitution - coding silent	Endometrium
COSM3562451	c.806T>C	p.I269T	Substitution - Missense	Skin
COSM488487	c.428C>A	p.T143N	Substitution - Missense	Breast
COSM5028932	c.2407G>A	p.D803N	Substitution - Missense	Breast
COSM4789783	c.2703G>A	p.K901K	Substitution - coding silent	Liver
COSM3780518	c.1919G>A	p.R640Q	Substitution - Missense	Pancreas
COSM72168	c.1337A>G	p.Q446R	Substitution - Missense	Ovary
COSM1331786	c.2524C>A	p.P842T	Substitution - Missense	Ovary
COSM5711839	c.2870G>A	p.R957H	Substitution - Missense	Soft_tissue
COSM5044688	c.1516C>A	p.R506R	Substitution - coding silent	Lung
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Large_intestine
COSM4156915	c.2581C>T	p.R861C	Substitution - Missense	Thyroid
COSM1123279	c.489C>A	p.T163T	Substitution - coding silent	Endometrium
COSM4110236	c.1216G>T	p.A406S	Substitution - Missense	Stomach
COSM3708676	c.2445C>G	p.I815M	Substitution - Missense	Liver
COSM6018507	c.2997C>T	p.P999P	Substitution - coding silent	Skin
COSM3092580	c.128C>T	p.A43V	Substitution - Missense	Large_intestine
COSM3092504	c.1528G>C	p.E510Q	Substitution - Missense	Upper_aerodigestive_tract
COSM1123278	c.525T>C	p.F175F	Substitution - coding silent	Endometrium
COSM211021	c.2444-1C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM276730	c.2130C>T	p.T710T	Substitution - coding silent	Large_intestine
COSM5450657	c.124G>A	p.A42T	Substitution - Missense	Large_intestine
COSM5507958	c.2849C>T	p.A950V	Substitution - Missense	Biliary_tract
COSM363470	c.1092T>G	p.F364L	Substitution - Missense	Lung
COSM4956909	c.2715G>T	p.Q905H	Substitution - Missense	Liver
COSM3786754	c.1352C>T	p.T451M	Substitution - Missense	Large_intestine
COSM1331789	c.2949C>T	p.R983R	Substitution - coding silent	Ovary
COSM4110248	c.924A>G	p.G308G	Substitution - coding silent	Stomach
COSM4850815	c.667G>A	p.E223K	Substitution - Missense	Cervix
COSM294700	c.620C>T	p.P207L	Substitution - Missense	Large_intestine
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Skin
COSM1315602	c.1260C>T	p.I420I	Substitution - coding silent	Urinary_tract
COSM4926013	c.1265A>G	p.E422G	Substitution - Missense	Liver
COSM355691	c.873G>A	p.M291I	Substitution - Missense	Lung
COSM3845077	c.2728G>A	p.D910N	Substitution - Missense	Breast
COSM4885677	c.455G>T	p.G152V	Substitution - Missense	Upper_aerodigestive_tract
COSM1123265	c.2593C>T	p.R865W	Substitution - Missense	Endometrium
COSM4993962	c.496G>A	p.A166T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3092510	c.1497A>T	p.E499D	Substitution - Missense	Upper_aerodigestive_tract
COSM4110232	c.1323+2T>C	p.?	Unknown	Stomach
COSM3940051	c.947-1G>A	p.?	Unknown	Oesophagus
COSM4714023	c.2587G>A	p.G863R	Substitution - Missense	Large_intestine
COSM3092507	c.1498C>A	p.L500I	Substitution - Missense	Upper_aerodigestive_tract
COSM1123279	c.489C>A	p.T163T	Substitution - coding silent	Endometrium
COSM4789783	c.2703G>A	p.K901K	Substitution - coding silent	Liver
COSM5650700	c.257C>T	p.T86M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2968679	c.2525C>A	p.P842Q	Substitution - Missense	Large_intestine
COSM5033868	c.1730+7T>G	p.?	Unknown	Skin
COSM457763	c.57C>T	p.F19F	Substitution - coding silent	Breast
COSM5064767	c.1270G>A	p.V424M	Substitution - Missense	Stomach
COSM1123279	c.489C>A	p.T163T	Substitution - coding silent	Endometrium
COSM5946752	c.1133T>G	p.I378S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4832150	c.1255G>A	p.E419K	Substitution - Missense	Cervix
COSM3379658	c.3026G>A	p.R1009K	Substitution - Missense	Pancreas
COSM4110217	c.1889C>T	p.A630V	Substitution - Missense	Stomach
COSM1123270	c.2046T>C	p.L682L	Substitution - coding silent	Endometrium
COSM4929032	c.410T>G	p.L137R	Substitution - Missense	Liver
COSM4891222	c.767G>T	p.W256L	Substitution - Missense	Upper_aerodigestive_tract
COSM3092504	c.1528G>C	p.E510Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4840028	c.2902C>T	p.R968C	Substitution - Missense	Cervix
COSM3092510	c.1497A>T	p.E499D	Substitution - Missense	Upper_aerodigestive_tract
COSM3786754	c.1352C>T	p.T451M	Substitution - Missense	Pancreas
COSM1724609	c.2383_2385delGAG	p.E795delE	Deletion - In frame	Large_intestine
COSM3092580	c.128C>T	p.A43V	Substitution - Missense	Large_intestine
COSM268512	c.1918C>T	p.R640W	Substitution - Missense	Large_intestine
COSM1220386	c.2318G>A	p.R773H	Substitution - Missense	Large_intestine
COSM4486288	c.2925C>G	p.P975P	Substitution - coding silent	Skin
COSM4110221	c.1827C>T	p.D609D	Substitution - coding silent	Stomach
COSM3845090	c.466G>C	p.E156Q	Substitution - Missense	Breast
COSM1123269	c.2083C>T	p.L695F	Substitution - Missense	Endometrium
COSM3694652	c.1599G>T	p.L533L	Substitution - coding silent	Large_intestine
COSM5472894	c.2457G>T	p.L819L	Substitution - coding silent	Large_intestine
COSM5570403	c.2554A>G	p.T852A	Substitution - Missense	Prostate
COSM4110225	c.1660G>A	p.D554N	Substitution - Missense	Stomach
COSM5824235	c.976G>T	p.D326Y	Substitution - Missense	Liver
COSM3092486	c.1725C>T	p.N575N	Substitution - coding silent	Large_intestine
COSM488487	c.428C>A	p.T143N	Substitution - Missense	Kidney
COSM3562432	c.1828G>A	p.E610K	Substitution - Missense	Stomach
COSM4714020	c.2796C>T	p.S932S	Substitution - coding silent	Large_intestine
COSM3562428	c.2204C>T	p.S735L	Substitution - Missense	Skin
COSM5643079	c.966G>T	p.L322L	Substitution - coding silent	Oesophagus
COSM1468636	c.78C>T	p.C26C	Substitution - coding silent	Large_intestine
COSM4110213	c.2284C>T	p.L762L	Substitution - coding silent	Stomach
COSM3092580	c.128C>T	p.A43V	Substitution - Missense	Large_intestine
COSM138155	c.1626+1G>A	p.?	Unknown	Skin
COSM756870	c.160G>T	p.E54*	Substitution - Nonsense	Lung
COSM4714036	c.416C>T	p.S139L	Substitution - Missense	Large_intestine
COSM3562455	c.306G>A	p.V102V	Substitution - coding silent	Skin
COSM1123271	c.1897A>G	p.I633V	Substitution - Missense	Endometrium
COSM1123272	c.1660G>T	p.D554Y	Substitution - Missense	Endometrium
COSM1715010	c.922_923GG>AA	p.G308K	Substitution - Missense	Skin
COSM3780522	c.1147C>T	p.R383*	Substitution - Nonsense	Pancreas
COSM4526929	c.1321G>A	p.E441K	Substitution - Missense	Skin
COSM457760	c.1834G>C	p.D612H	Substitution - Missense	Breast
COSM1491103	c.1537G>A	p.A513T	Substitution - Missense	Breast
COSM3562440	c.1517G>A	p.R506Q	Substitution - Missense	Skin
COSM4110240	c.1138C>T	p.R380C	Substitution - Missense	Stomach
COSM488488	c.267A>G	p.R89R	Substitution - coding silent	Kidney
COSM72167	c.2358G>C	p.W786C	Substitution - Missense	Ovary
COSM292328	c.1279G>A	p.V427I	Substitution - Missense	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for PHF8.

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UPP1	120	S	Phosphoserine	CDK1	No	None detected
Q9UPP1	651	S	Phosphoserine	-	No	None detected
Q9UPP1	704	Y	Phosphotyrosine	-	No	None detected
Q9UPP1	705	T	Phosphothreonine	-	No	None detected
Q9UPP1	706	T	Phosphothreonine	-	No	None detected
Q9UPP1	722	S	Phosphoserine	-	No	None detected
Q9UPP1	804	S	Phosphoserine	-	No	None detected
Q9UPP1	826	S	Phosphoserine	-	No	None detected
Q9UPP1	834	S	Phosphoserine	-	No	None detected
Q9UPP1	854	S	Phosphoserine	-	No	None detected
Q9UPP1	857	S	Phosphoserine	-	No	None detected
Q9UPP1	880	S	Phosphoserine	-	No	None detected

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.568	5.512	-0.068	0.752	NS
BRCA	Breast invasive carcinoma	112	1100	5.604	5.953	0.315	1.78e-07	NS
CESC	Cervical and endocervical cancers	3	306	4.962	5.358	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.299	5.579	0.332	0.000186	NS
ESCA	Esophageal carcinoma	11	185	5.773	5.953	0.183	0.371	NS
GBM	Glioblastoma multiforme	5	166	4.518	5.268	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.207	4.896	-0.197	0.129	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.645	5.233	-0.481	4.48e-19	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.458	5.065	-0.506	1.06e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.544	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.34	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.23	5.001	-0.31	0.0186	NS
LUAD	Lung adenocarcinoma	59	517	5.203	5.532	0.449	1.2e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	5.241	5.807	0.63	1.42e-09	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.18	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.078	5.16	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.803	5.322	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.113	6.495	0.429	3.19e-05	NS
READ	Rectum adenocarcinoma	10	167	5.202	5.766	0.669	0.000347	Over
SARC	Sarcoma	2	263	4.22	5.04	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.09	5.518	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.259	5.671	0.385	2.21e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.194	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.465	5.496	0.072	0.257	NS
THYM	Thymoma	2	120	6.033	5.534	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.506	6.017	0.517	0.000419	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	10.2
Adrenal gland	10.1
Appendix	18.2
Bone marrow	10.5
Breast	14.7
Cerebral cortex	10
Cervix, uterine	13.3
Colon	9.3
Duodenum	11
Endometrium	21.2
Epididymis	84.6
Esophagus	11.2
Fallopian tube	20.5
Gallbladder	14.6
Heart muscle	4.2
Kidney	10.1
Liver	9.5
Lung	13.7
Lymph node	19.3
Ovary	22.2
Pancreas	3.5
Parathyroid gland	21.3
Placenta	18.8
Prostate	21.5
Rectum	10.8
Salivary gland	4.8
Seminal vesicle	25.6
Skeletal muscle	2.9
Skin	13.9
Small intestine	11.3
Smooth muscle	13.8
Spleen	19.3
Stomach	9.4
Testis	75.6
Thyroid gland	18.3
Tonsil	15.2
Urinary bladder	13.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27183383	overexpression	Breast Carcinoma	USP7 was overexpressed in breast carcinomas, and the level of expression positively correlated with expression of PHF8 and cyclin A2 and with the histological grade of breast cancer.
26309412	overexpression	Prostate Carcinoma	Plant homeodomain finger protein 8 (PHF8) is upregulated in human PCa tissues and cell lines.
25065740	overexpression	Non-Small Cell Lung Carcinoma	PHF8 is up-regulated in human NSCLC tissues, and high PHF8 expression predicts poor survival.
22120715	overexpression	Prostate Carcinoma	Our results show that the KDMs JARID1B, PHF8, KDM3A, KDM3B and KDM4A were highly expressed in clinical PrCa samples.
28401003	Overexpression	Gastric Carcinoma	In this report, we show that PHF8 expression is upregulated in GC tissues, and the enhanced PHF8 level indicates a poor prognosis of GC patients.
27991916	Overexpression	Prostate Carcinoma	Importantly, we observed that PHF8 is highly expressed in clinical androgen deprived prostate cancer samples and expression of PHF8 correlates with increased levels of HIF1α and HIF2α.

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.245	5.9e-07	19.3	64.9	15.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.22	2.87e-13	15.9	66	18.1	Neutral
CESC	Cervical and endocervical cancers	292	0.125	0.0321	24	63.4	12.7	Neutral
COAD	Colon adenocarcinoma	449	0.127	0.00704	14.7	68.8	16.5	Neutral
ESCA	Esophageal carcinoma	183	0.235	0.00139	33.3	51.9	14.8	Neutral
GBM	Glioblastoma multiforme	147	-0.003	0.974	22.4	73.5	4.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.199	5.22e-06	26.3	63.2	10.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.204	2.54e-06	9.1	85.5	5.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.129	0.0282	11.1	55.9	33	Neutral
LAML	Acute Myeloid Leukemia	166	0.012	0.879	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.062	0.16	13.8	74.5	11.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.054	0.305	26.9	62.1	11	Neutral
LUAD	Lung adenocarcinoma	512	0.221	4.67e-07	18.4	69.9	11.7	Neutral
LUSC	Lung squamous cell carcinoma	498	0.265	1.96e-09	26.1	59	14.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.318	1.78e-08	42.3	29.3	28.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.143	0.0571	15.3	80.8	4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.095	0.228	27.8	67.3	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.072	0.109	6.3	90.6	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.277	0.000329	18.3	64.6	17.1	Neutral
SARC	Sarcoma	255	0.274	9.1e-06	19.2	43.1	37.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.062	0.234	22.6	61.9	15.5	Neutral
STAD	Stomach adenocarcinoma	413	0.109	0.0271	14.8	73.1	12.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.079	0.334	18.7	64	17.3	Neutral
THCA	Thyroid carcinoma	497	-0.074	0.101	1	97.6	1.4	Neutral
THYM	Thymoma	119	-0.006	0.952	5.9	92.4	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.075	0.0837	11.7	72.3	16	Neutral

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.128	0.00825	17	408	-0.015	0.0617	NS/NA
BRCA	Breast invasive carcinoma	-0.102	0.00267	83	785	-0.06	7.91e-28	NS/NA
CESC	Cervical and endocervical cancers	-0.271	1.45e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.211	0.000167	19	297	0.002	0.967	NS/NA
ESCA	Esophageal carcinoma	-0.225	0.00165	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.006	0.964	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.149	0.000488	20	522	0.003	0.959	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.045	0.401	24	319	0.001	0.0811	NS/NA
KIRP	Kidney renal papillary cell carcinoma	0.054	0.355	23	275	0.001	0.369	NS/NA
LAML	Acute Myeloid Leukemia	-0.195	0.011	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.091	0.0363	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.168	0.000625	41	373	0.001	0.0938	NS/NA
LUAD	Lung adenocarcinoma	-0.126	0.00589	21	456	0.168	0.338	NS/NA
LUSC	Lung squamous cell carcinoma	-0.145	0.0047	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	0.217	0.581	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.146	0.0492	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.133	0.0698	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.041	0.345	35	498	-0.022	1.16e-06	NS/NA
READ	Rectum adenocarcinoma	-0.113	0.26	2	99	NA	NA	NS/NA
SARC	Sarcoma	0.01	0.87	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.105	0.0222	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.218	2.24e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.347	1e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.038	0.367	50	509	-0.049	0.866	NS/NA
THYM	Thymoma	0.063	0.488	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.166	0.000317	34	431	-0.073	2.93e-21	NS/NA

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	3	High
Liver	0	Not detected
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	3	High
Oral mucosa	0	Not detected
Ovary	1	Low
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	1	Low
Stomach	3	High
Testis	2	Medium
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.352	NS	24476821
BRCA	Breast invasive carcinoma	521	1.18e-17	Significant	23000897
COAD	Colon adenocarcinoma	149	2.32e-05	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00013	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.43e-19	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.633	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.000774	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000857	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	7.21e-11	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000433	Significant	21720365
PRAD	Prostate adenocarcinoma	333	4.65e-14	Significant	26544944
READ	Rectum adenocarcinoma	67	0.00232	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.611	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0138	Significant	25079317
THCA	Thyroid carcinoma	391	2.09e-06	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00925	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.614	0.0224	Longer
BRCA	Breast invasive carcinoma	1079	1.343	0.207	NS
CESC	Cervical and endocervical cancers	291	0.644	0.189	NS
COAD	Colon adenocarcinoma	439	1.307	0.365	NS
ESCA	Esophageal carcinoma	184	2.15	0.0269	Shorter
GBM	Glioblastoma multiforme	158	0.708	0.169	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.815	0.288	NS
KIRC	Kidney renal clear cell carcinoma	531	0.934	0.76	NS
KIRP	Kidney renal papillary cell carcinoma	287	3.808	0.00207	Shorter
LAML	Acute Myeloid Leukemia	149	0.533	0.0401	Longer
LGG	Brain Lower Grade Glioma	511	2.145	0.00568	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.524	0.0111	Longer
LUAD	Lung adenocarcinoma	502	0.666	0.0549	NS
LUSC	Lung squamous cell carcinoma	494	0.702	0.063	NS
OV	Ovarian serous cystadenocarcinoma	303	1.204	0.381	NS
PAAD	Pancreatic adenocarcinoma	177	0.732	0.301	NS
PCPG	Pheochromocytoma and Paraganglioma	179	633912313.473	0.0741	NS
PRAD	Prostate adenocarcinoma	497	1.801	0.626	NS
READ	Rectum adenocarcinoma	159	2.822	0.174	NS
SARC	Sarcoma	259	1.083	0.795	NS
SKCM	Skin Cutaneous Melanoma	459	1.211	0.33	NS
STAD	Stomach adenocarcinoma	388	0.708	0.123	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.157	NS
THCA	Thyroid carcinoma	500	0.301	0.27	NS
THYM	Thymoma	119	0.418	0.463	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.026	0.932	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.13	0.00878	Lower
BRCA	Breast invasive carcinoma	1071	0.038	0.218	NS
CESC	Cervical and endocervical cancers	167	0.019	0.812	NS
COAD	Colon adenocarcinoma	445	0.045	0.344	NS
ESCA	Esophageal carcinoma	162	0.133	0.0909	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.014	0.769	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.049	0.257	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.151	0.0151	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.13	0.0155	Lower
LUAD	Lung adenocarcinoma	507	0.038	0.391	NS
LUSC	Lung squamous cell carcinoma	497	0.031	0.493	NS
OV	Ovarian serous cystadenocarcinoma	302	0.052	0.372	NS
PAAD	Pancreatic adenocarcinoma	176	-0.101	0.182	NS
READ	Rectum adenocarcinoma	156	0.104	0.197	NS
SKCM	Skin Cutaneous Melanoma	410	0.005	0.921	NS
STAD	Stomach adenocarcinoma	392	-0.04	0.433	NS
TGCT	Testicular Germ Cell Tumors	81	-0.141	0.211	NS
THCA	Thyroid carcinoma	499	-0.027	0.549	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.075	0.0948	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.049	0.421	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.153	0.000638	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.064	0.143	NS
LGG	Brain Lower Grade Glioma	514	0.144	0.00105	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.087	0.097	NS
OV	Ovarian serous cystadenocarcinoma	296	0.125	0.0322	Higher
PAAD	Pancreatic adenocarcinoma	176	-0.083	0.275	NS
STAD	Stomach adenocarcinoma	406	-0.103	0.0374	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.098	0.0237	Higher

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

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> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for PHF8.

Summary
Symbol	PHF8
Name	PHD finger protein 8
Aliases	KIAA1111; JHDM1F; jumonji C domain-containing histone demethylase 1F; MRXSSD; Histone lysine demethylase PHF ......
Location	Xp11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27183383	Breast Carcinoma	upstream	USP7	positive regulation	We showed that USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 and that the interaction between USP7 and PHF8 is augmented during DNA damage.
26309412	Prostate Carcinoma	downstream	miR-125b	regulation	Furthermore, miR-125b is a target of PHF8, and miR-125b seems to be essential for the hyper proliferation of PCa cells in the presence of PHF8.
25065740	Non-Small Cell Lung Carcinoma	downstream	miR-21	positive regulation	PHF8 promotes miR-21 expression in human lung cancer, and miR-21 knockdown blocks the effects of PHF8 on proliferation and apoptosis of lung cancer cells.
28401003	Gastric Carcinoma	partner	β-catenin	Binding	Mechanistically, PHF8 interacts with β-catenin, and binds to the promoter region of vimentin, leading to the promotion of vimentin transcription
28401003	Gastric Carcinoma	downstream	Vimentin	Positive regulation	Mechanistically, PHF8 interacts with β-catenin, and binds to the promoter region of vimentin, leading to the promotion of vimentin transcription
27991916	Prostate Carcinoma	partner	HIF1α; HIF2α	Positive correlation	Importantly, we observed that PHF8 is highly expressed in clinical androgen deprived prostate cancer samples and expression of PHF8 correlates with increased levels of HIF1α and HIF2α.
27991916	Prostate Carcinoma	downstream	AR	Positive regulation	The elevated PHF8 in turn promotes the AR signaling pathway and prostate cancer progression.