CR2Cancer

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain
PF00400 WD domain

Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007346 regulation of mitotic cell cycle GO:0008286 insulin receptor signaling pathway GO:0008360 regulation of cell shape GO:0022604 regulation of cell morphogenesis GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0043434 response to peptide hormone GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway GO:0045787 positive regulation of cell cycle GO:0045840 positive regulation of mitotic nuclear division GO:0045931 positive regulation of mitotic cell cycle GO:0048009 insulin-like growth factor receptor signaling pathway GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090068 positive regulation of cell cycle process GO:0097191 extrinsic apoptotic signaling pathway GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function	GO:0005158 insulin receptor binding GO:0042393 histone binding GO:0070577 lysine-acetylated histone binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5024783	c.1571C>A	p.P524H	Substitution - Missense	Large_intestine
COSM743058	c.5046C>G	p.I1682M	Substitution - Missense	Lung
COSM364043	c.4360G>T	p.A1454S	Substitution - Missense	Lung
COSM421228	c.4700G>C	p.S1567T	Substitution - Missense	Urinary_tract
COSM4571616	c.5020T>A	p.L1674I	Substitution - Missense	Skin
COSM196940	c.2113G>A	p.A705T	Substitution - Missense	Lung
COSM3176006	c.1112T>C	p.I371T	Substitution - Missense	Large_intestine
COSM1446055	c.2105A>T	p.H702L	Substitution - Missense	Large_intestine
COSM3762194	c.3278T>C	p.L1093P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5202444	c.2656_2658delGAA	p.E886delE	Deletion - In frame	Breast
COSM743051	c.2196A>T	p.V732V	Substitution - coding silent	Lung
COSM5427326	c.3468G>A	p.W1156*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1081853	c.3753C>T	p.F1251F	Substitution - coding silent	Endometrium
COSM3176019	c.381G>A	p.A127A	Substitution - coding silent	Stomach
COSM1329537	c.3788A>T	p.Q1263L	Substitution - Missense	Ovary
COSM276731	c.3838T>G	p.L1280V	Substitution - Missense	Endometrium
COSM1220395	c.2537G>T	p.S846I	Substitution - Missense	Large_intestine
COSM5996780	c.4002A>G	p.Q1334Q	Substitution - coding silent	Prostate
COSM451824	c.3831_3833delGAA	p.K1278delK	Deletion - In frame	Breast
COSM3875673	c.2307C>A	p.P769P	Substitution - coding silent	Stomach
COSM1081869	c.1187G>A	p.R396Q	Substitution - Missense	Large_intestine
COSM1672580	c.1378C>A	p.H460N	Substitution - Missense	Large_intestine
COSM4004130	c.2621C>T	p.T874I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1081853	c.3753C>T	p.F1251F	Substitution - coding silent	Upper_aerodigestive_tract
COSM1634943	c.1918A>G	p.I640V	Substitution - Missense	Liver
COSM5997048	c.4284T>A	p.A1428A	Substitution - coding silent	Prostate
COSM1643149	c.4055A>G	p.D1352G	Substitution - Missense	Stomach
COSM304495	c.2897A>G	p.Y966C	Substitution - Missense	Large_intestine
COSM3875666	c.4706G>A	p.G1569D	Substitution - Missense	Stomach
COSM5571848	c.2285T>A	p.V762D	Substitution - Missense	Prostate
COSM1081854	c.3733A>G	p.I1245V	Substitution - Missense	Endometrium
COSM3875679	c.510T>C	p.Y170Y	Substitution - coding silent	Stomach
COSM1621963	c.4416A>T	p.E1472D	Substitution - Missense	Liver
COSM3949487	c.5147C>T	p.P1716L	Substitution - Missense	Lung
COSM4601317	c.4061G>C	p.R1354T	Substitution - Missense	Upper_aerodigestive_tract
COSM4604000	c.1041T>G	p.V347V	Substitution - coding silent	Upper_aerodigestive_tract
COSM269879	c.3288T>C	p.P1096P	Substitution - coding silent	Large_intestine
COSM4996758	c.5066C>G	p.S1689C	Substitution - Missense	Upper_aerodigestive_tract
COSM5555350	c.1058G>A	p.G353D	Substitution - Missense	Prostate
COSM1159395	c.1428G>A	p.P476P	Substitution - coding silent	Pancreas
COSM391756	c.2270_2297del28	p.R757fs*47	Deletion - Frameshift	Lung
COSM4393179	c.340A>T	p.S114C	Substitution - Missense	Prostate
COSM3176006	c.1112T>C	p.I371T	Substitution - Missense	Large_intestine
COSM5617858	c.4786A>G	p.K1596E	Substitution - Missense	Breast
COSM170748	c.2925C>T	p.V975V	Substitution - coding silent	Large_intestine
COSM1081855	c.3686G>A	p.R1229Q	Substitution - Missense	Endometrium
COSM4392294	c.2581A>T	p.I861F	Substitution - Missense	Prostate
COSM4586943	c.3423T>C	p.D1141D	Substitution - coding silent	Bone
COSM3719982	c.1606G>T	p.G536*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5405869	c.3877C>T	p.P1293S	Substitution - Missense	Skin
COSM98117	c.3301C>G	p.Q1101E	Substitution - Missense	Upper_aerodigestive_tract
COSM3875672	c.2466C>T	p.G822G	Substitution - coding silent	Stomach
COSM1741812	c.3088A>G	p.T1030A	Substitution - Missense	Urinary_tract
COSM4482455	c.2609C>T	p.P870L	Substitution - Missense	Skin
COSM5427326	c.3468G>A	p.W1156*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4805896	c.3617T>C	p.L1206P	Substitution - Missense	Liver
COSM4586941	c.4639A>C	p.N1547H	Substitution - Missense	Bone
COSM5405870	c.3444C>T	p.I1148I	Substitution - coding silent	Skin
COSM1446056	c.1261A>C	p.K421Q	Substitution - Missense	Large_intestine
COSM1643149	c.4055A>G	p.D1352G	Substitution - Missense	Stomach
COSM3630087	c.3623C>T	p.T1208I	Substitution - Missense	Skin
COSM1081856	c.3561C>A	p.P1187P	Substitution - coding silent	Endometrium
COSM1081867	c.1642A>G	p.K548E	Substitution - Missense	Endometrium
COSM421229	c.5298G>C	p.M1766I	Substitution - Missense	Urinary_tract
COSM3875670	c.3728G>A	p.S1243N	Substitution - Missense	Stomach
COSM3875678	c.1168C>T	p.R390C	Substitution - Missense	Stomach
COSM176342	c.4584G>T	p.K1528N	Substitution - Missense	Endometrium
COSM743056	c.4520G>A	p.R1507K	Substitution - Missense	Lung
COSM3662731	c.1829A>T	p.E610V	Substitution - Missense	Liver
COSM1621962	c.4643C>G	p.S1548C	Substitution - Missense	Liver
COSM1081850	c.3874G>A	p.V1292M	Substitution - Missense	Endometrium
COSM421227	c.1027C>T	p.H343Y	Substitution - Missense	Urinary_tract
COSM1262074	c.1133A>G	p.N378S	Substitution - Missense	Oesophagus
COSM1446046	c.4409A>T	p.K1470I	Substitution - Missense	Large_intestine
COSM5357762	c.441G>A	p.A147A	Substitution - coding silent	Large_intestine
COSM3430900	c.1508G>A	p.R503Q	Substitution - Missense	Large_intestine
COSM1446061	c.329G>A	p.R110H	Substitution - Missense	Large_intestine
COSM4985617	c.3418A>C	p.T1140P	Substitution - Missense	Soft_tissue
COSM1697565	c.2348T>G	p.L783R	Substitution - Missense	Skin
COSM3941849	c.4189C>G	p.P1397A	Substitution - Missense	Oesophagus
COSM5919068	c.1819C>T	p.P607S	Substitution - Missense	Skin
COSM276733	c.1036C>T	p.R346W	Substitution - Missense	Large_intestine
COSM5811285	c.5111A>G	p.D1704G	Substitution - Missense	Liver
COSM341452	c.3023G>T	p.G1008V	Substitution - Missense	Lung
COSM379390	c.2517G>T	p.W839C	Substitution - Missense	Lung
COSM1220394	c.1186C>T	p.R396*	Substitution - Nonsense	Large_intestine
COSM3762194	c.3278T>C	p.L1093P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1329538	c.4971G>A	p.K1657K	Substitution - coding silent	Ovary
COSM5592505	c.2020T>C	p.S674P	Substitution - Missense	Skin
COSM4155298	c.5062C>G	p.P1688A	Substitution - Missense	Kidney
COSM4882465	c.376G>T	p.A126S	Substitution - Missense	Upper_aerodigestive_tract
COSM4714049	c.1687C>T	p.R563W	Substitution - Missense	Large_intestine
COSM1621963	c.4416A>T	p.E1472D	Substitution - Missense	Liver
COSM5600203	c.5235G>A	p.K1745K	Substitution - coding silent	Skin
COSM4540876	c.2903G>A	p.R968Q	Substitution - Missense	Skin
COSM5600203	c.5235G>A	p.K1745K	Substitution - coding silent	Skin
COSM1081841	c.4901T>G	p.L1634R	Substitution - Missense	Endometrium
COSM1446062	c.288A>G	p.G96G	Substitution - coding silent	Large_intestine
COSM5600203	c.5235G>A	p.K1745K	Substitution - coding silent	Skin
COSM3358051	c.311G>T	p.G104V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3875668	c.4513C>G	p.R1505G	Substitution - Missense	Stomach
COSM1081845	c.4495G>T	p.E1499*	Substitution - Nonsense	Endometrium
COSM1262073	c.14G>A	p.R5K	Substitution - Missense	Oesophagus
COSM1159395	c.1428G>A	p.P476P	Substitution - coding silent	Large_intestine
COSM3762194	c.3278T>C	p.L1093P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3928620	c.4895C>G	p.S1632*	Substitution - Nonsense	Central_nervous_system
COSM743050	c.1336A>G	p.M446V	Substitution - Missense	Lung
COSM1081859	c.3289G>C	p.D1097H	Substitution - Missense	Endometrium
COSM196940	c.2113G>A	p.A705T	Substitution - Missense	Large_intestine
COSM1081842	c.4853T>C	p.V1618A	Substitution - Missense	Endometrium
COSM3175995	c.1934G>A	p.S645N	Substitution - Missense	Upper_aerodigestive_tract
COSM4714050	c.1545C>T	p.G515G	Substitution - coding silent	Large_intestine
COSM3430899	c.3928C>T	p.R1310C	Substitution - Missense	Breast
COSM3875674	c.2101A>T	p.M701L	Substitution - Missense	Stomach
COSM4473799	c.1874C>T	p.S625F	Substitution - Missense	Skin
COSM3686351	c.3657-4delT	p.?	Unknown	Prostate
COSM1568252	c.5113T>G	p.L1705V	Substitution - Missense	Large_intestine
COSM5630796	c.2192G>C	p.G731A	Substitution - Missense	Oesophagus
COSM1446050	c.3929G>A	p.R1310H	Substitution - Missense	Large_intestine
COSM1081862	c.2926G>A	p.E976K	Substitution - Missense	Endometrium
COSM1496424	c.695C>G	p.A232G	Substitution - Missense	Kidney
COSM4932502	c.4168A>T	p.S1390C	Substitution - Missense	Liver
COSM1717591	c.2137G>T	p.E713*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5732101	c.275A>G	p.Q92R	Substitution - Missense	Pancreas
COSM1081863	c.2093T>A	p.V698E	Substitution - Missense	Endometrium
COSM484378	c.5183A>C	p.D1728A	Substitution - Missense	Kidney
COSM4586942	c.3805A>G	p.I1269V	Substitution - Missense	Bone
COSM1672579	c.4136T>C	p.M1379T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3762194	c.3278T>C	p.L1093P	Substitution - Missense	Large_intestine
COSM4546956	c.4111G>C	p.E1371Q	Substitution - Missense	Skin
COSM1262075	c.3363G>A	p.E1121E	Substitution - coding silent	Stomach
COSM3175978	c.2959A>G	p.N987D	Substitution - Missense	Large_intestine
COSM235195	c.2964C>T	p.P988P	Substitution - coding silent	Skin
COSM1487942	c.1292C>A	p.A431D	Substitution - Missense	Breast
COSM1672580	c.1378C>A	p.H460N	Substitution - Missense	Large_intestine
COSM1081847	c.4448G>A	p.R1483Q	Substitution - Missense	Endometrium
COSM4004130	c.2621C>T	p.T874I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4996757	c.5279A>G	p.K1760R	Substitution - Missense	Upper_aerodigestive_tract
COSM743055	c.3520C>A	p.Q1174K	Substitution - Missense	Lung
COSM451826	c.2887G>A	p.E963K	Substitution - Missense	Breast
COSM39640	c.737A>G	p.D246G	Substitution - Missense	Central_nervous_system
COSM3698011	c.338A>C	p.K113T	Substitution - Missense	Large_intestine
COSM3762193	c.4228C>T	p.L1410L	Substitution - coding silent	Large_intestine
COSM4488586	c.3350C>T	p.P1117L	Substitution - Missense	Skin
COSM4894542	c.83G>A	p.C28Y	Substitution - Missense	Skin
COSM4357132	c.2416C>T	p.P806S	Substitution - Missense	Bone
COSM246567	c.2258C>A	p.S753*	Substitution - Nonsense	Prostate
COSM1159395	c.1428G>A	p.P476P	Substitution - coding silent	Pancreas
COSM1446050	c.3929G>A	p.R1310H	Substitution - Missense	Liver
COSM3720216	c.3677G>A	p.W1226*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1754937	c.1607G>C	p.G536A	Substitution - Missense	Urinary_tract
COSM4714045	c.5255A>G	p.E1752G	Substitution - Missense	Large_intestine
COSM33476	c.5300G>T	p.R1767I	Substitution - Missense	Large_intestine
COSM4714051	c.1050delT	p.F350fs*32	Deletion - Frameshift	Large_intestine
COSM3630088	c.163G>A	p.E55K	Substitution - Missense	Skin
COSM223111	c.3560C>T	p.P1187L	Substitution - Missense	Skin
COSM1081844	c.4790C>T	p.A1597V	Substitution - Missense	Endometrium
COSM5040730	c.4264T>G	p.L1422V	Substitution - Missense	Liver
COSM1697564	c.5146C>T	p.P1716S	Substitution - Missense	Skin
COSM1220396	c.995-1G>A	p.?	Unknown	Large_intestine
COSM3175978	c.2959A>G	p.N987D	Substitution - Missense	Large_intestine
COSM1329536	c.2312T>C	p.V771A	Substitution - Missense	Ovary
COSM3176004	c.1202G>A	p.S401N	Substitution - Missense	Large_intestine
COSM5031133	c.380C>T	p.A127V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM98117	c.3301C>G	p.Q1101E	Substitution - Missense	Upper_aerodigestive_tract
COSM1081839	c.5300G>A	p.R1767K	Substitution - Missense	Endometrium
COSM4714052	c.444T>C	p.D148D	Substitution - coding silent	Large_intestine
COSM1081874	c.764G>A	p.R255Q	Substitution - Missense	Large_intestine
COSM1446044	c.4991A>C	p.K1664T	Substitution - Missense	Large_intestine
COSM5579314	c.4682C>T	p.P1561L	Substitution - Missense	Skin
COSM1081865	c.1889A>C	p.Q630P	Substitution - Missense	Endometrium
COSM1220394	c.1186C>T	p.R396*	Substitution - Nonsense	Large_intestine
COSM3762192	c.4236T>A	p.A1412A	Substitution - coding silent	Large_intestine
COSM1081869	c.1187G>A	p.R396Q	Substitution - Missense	Endometrium
COSM1167850	c.1928_1929insT	p.D644fs*18	Insertion - Frameshift	Skin
COSM1754937	c.1607G>C	p.G536A	Substitution - Missense	Urinary_tract
COSM3995130	c.1444C>T	p.L482F	Substitution - Missense	Kidney
COSM4714046	c.3383T>C	p.V1128A	Substitution - Missense	Large_intestine
COSM4649020	c.2430A>G	p.E810E	Substitution - coding silent	Large_intestine
COSM5835268	c.2377delC	p.Q793fs*20	Deletion - Frameshift	Breast
COSM1081851	c.3861G>T	p.E1287D	Substitution - Missense	Endometrium
COSM5600203	c.5235G>A	p.K1745K	Substitution - coding silent	Skin
COSM1634944	c.1816G>C	p.V606L	Substitution - Missense	Liver
COSM4604244	c.1301G>A	p.R434Q	Substitution - Missense	Upper_aerodigestive_tract
COSM283996	c.5131C>T	p.R1711C	Substitution - Missense	Large_intestine
COSM5563251	c.3940C>T	p.Q1314*	Substitution - Nonsense	Prostate
COSM283998	c.2390G>A	p.R797H	Substitution - Missense	Stomach
COSM3430901	c.1226G>A	p.R409H	Substitution - Missense	Large_intestine
COSM1161640	c.609T>G	p.D203E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1081875	c.240T>C	p.H80H	Substitution - coding silent	Endometrium
COSM5442545	c.760C>G	p.L254V	Substitution - Missense	Oesophagus
COSM3176003	c.1382T>C	p.V461A	Substitution - Missense	Large_intestine
COSM5948915	c.600+2T>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3430899	c.3928C>T	p.R1310C	Substitution - Missense	Pancreas
COSM5571863	c.2313C>T	p.V771V	Substitution - coding silent	Prostate
COSM4880462	c.3180T>C	p.D1060D	Substitution - coding silent	Large_intestine
COSM5428677	c.709A>T	p.N237Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5600203	c.5235G>A	p.K1745K	Substitution - coding silent	Skin
COSM5564705	c.5142G>A	p.R1714R	Substitution - coding silent	Prostate
COSM3831104	c.1383C>G	p.V461V	Substitution - coding silent	Breast
COSM1634944	c.1816G>C	p.V606L	Substitution - Missense	Liver
COSM5029832	c.3706C>T	p.R1236*	Substitution - Nonsense	Bone
COSM1081858	c.3406A>G	p.S1136G	Substitution - Missense	Endometrium
COSM4714047	c.3264G>A	p.Q1088Q	Substitution - coding silent	Large_intestine
COSM1081849	c.4018C>T	p.P1340S	Substitution - Missense	Endometrium
COSM4997675	c.341G>A	p.S114N	Substitution - Missense	Large_intestine
COSM3175967	c.3707G>A	p.R1236Q	Substitution - Missense	Large_intestine
COSM4714048	c.2569G>A	p.A857T	Substitution - Missense	Large_intestine
COSM276732	c.2742A>C	p.K914N	Substitution - Missense	Large_intestine
COSM219580	c.1285A>G	p.M429V	Substitution - Missense	Breast
COSM5405868	c.4715A>T	p.N1572I	Substitution - Missense	Skin
COSM5582104	c.4021T>A	p.F1341I	Substitution - Missense	Skin
COSM5032130	c.1225C>G	p.R409G	Substitution - Missense	Pancreas
COSM1729799	c.1136+1G>A	p.?	Unknown	Liver
COSM3175972	c.3209A>G	p.D1070G	Substitution - Missense	Large_intestine
COSM5492107	c.1784G>A	p.G595D	Substitution - Missense	Biliary_tract
COSM1081869	c.1187G>A	p.R396Q	Substitution - Missense	Endometrium
COSM5557366	c.1698T>C	p.I566I	Substitution - coding silent	Prostate
COSM5455523	c.3237C>A	p.A1079A	Substitution - coding silent	Large_intestine
COSM4747540	c.1504delA	p.I502fs*7	Deletion - Frameshift	Stomach
COSM1081864	c.2026A>C	p.S676R	Substitution - Missense	Endometrium
COSM3875667	c.4514G>A	p.R1505Q	Substitution - Missense	Stomach
COSM338824	c.2970A>G	p.K990K	Substitution - coding silent	Lung
COSM1319060	c.630G>T	p.W210C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1081866	c.1851C>A	p.L617L	Substitution - coding silent	Endometrium
COSM1161640	c.609T>G	p.D203E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3175988	c.2306C>A	p.P769H	Substitution - Missense	Large_intestine
COSM451825	c.3457G>A	p.D1153N	Substitution - Missense	Breast
COSM1568249	c.1153C>T	p.R385C	Substitution - Missense	Large_intestine
COSM338368	c.375G>T	p.L125L	Substitution - coding silent	Lung
COSM3662731	c.1829A>T	p.E610V	Substitution - Missense	Liver
COSM3175955	c.4602T>G	p.A1534A	Substitution - coding silent	Large_intestine
COSM4473799	c.1874C>T	p.S625F	Substitution - Missense	Skin
COSM3831103	c.2326G>A	p.A776T	Substitution - Missense	Breast
COSM5564101	c.3212G>A	p.R1071H	Substitution - Missense	Prostate
COSM3430899	c.3928C>T	p.R1310C	Substitution - Missense	Large_intestine
COSM4939508	c.2781G>C	p.V927V	Substitution - coding silent	Liver
COSM5948939	c.600+3A>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM394329	c.62G>T	p.R21L	Substitution - Missense	Lung
COSM1081843	c.4810T>C	p.S1604P	Substitution - Missense	Endometrium
COSM5931872	c.2044C>T	p.H682Y	Substitution - Missense	Skin
COSM4928762	c.2770-1G>T	p.?	Unknown	Liver
COSM1081868	c.1330A>C	p.N444H	Substitution - Missense	Endometrium
COSM1568249	c.1153C>T	p.R385C	Substitution - Missense	Stomach
COSM4964777	c.2426C>T	p.S809L	Substitution - Missense	Pancreas
COSM1568250	c.2585A>G	p.N862S	Substitution - Missense	Large_intestine
COSM1621962	c.4643C>G	p.S1548C	Substitution - Missense	Liver
COSM3875669	c.4263T>G	p.V1421V	Substitution - coding silent	Stomach
COSM484381	c.200A>G	p.Y67C	Substitution - Missense	Kidney
COSM1081860	c.3193C>T	p.R1065*	Substitution - Nonsense	Endometrium
COSM5802370	c.3155_3174del20	p.L1052fs*2	Deletion - Frameshift	Breast
COSM385374	c.3981A>C	p.E1327D	Substitution - Missense	Lung
COSM4805896	c.3617T>C	p.L1206P	Substitution - Missense	Liver
COSM3745369	c.5172A>G	p.K1724K	Substitution - coding silent	Liver
COSM5749868	c.3059G>A	p.C1020Y	Substitution - Missense	Genital_tract
COSM4473510	c.1855C>T	p.P619S	Substitution - Missense	Skin
COSM4426334	c.5362A>G	p.R1788G	Substitution - Missense	Oesophagus
COSM743048	c.455C>T	p.S152L	Substitution - Missense	Lung
COSM1081852	c.3754G>A	p.V1252M	Substitution - Missense	Endometrium
COSM3686351	c.3657-4delT	p.?	Unknown	Large_intestine
COSM1081874	c.764G>A	p.R255Q	Substitution - Missense	Endometrium
COSM3175972	c.3209A>G	p.D1070G	Substitution - Missense	Large_intestine
COSM484380	c.1920C>T	p.I640I	Substitution - coding silent	Kidney
COSM3875671	c.3256G>A	p.E1086K	Substitution - Missense	Stomach
COSM4885608	c.2286T>A	p.V762V	Substitution - coding silent	Upper_aerodigestive_tract
COSM3430898	c.3949G>A	p.D1317N	Substitution - Missense	Large_intestine
COSM743059	c.5348C>A	p.S1783Y	Substitution - Missense	Lung
COSM4714044	c.5436A>C	p.E1812D	Substitution - Missense	Large_intestine
COSM196940	c.2113G>A	p.A705T	Substitution - Missense	Large_intestine
COSM1081872	c.874G>T	p.D292Y	Substitution - Missense	Endometrium
COSM1081857	c.3503T>G	p.I1168S	Substitution - Missense	Endometrium
COSM5749394	c.2759G>C	p.R920T	Substitution - Missense	Genital_tract
COSM5880233	c.4381A>G	p.K1461E	Substitution - Missense	Skin
COSM1316292	c.2033C>T	p.T678I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4915923	c.2667A>G	p.K889K	Substitution - coding silent	Liver
COSM1446047	c.4278A>C	p.K1426N	Substitution - Missense	Large_intestine
COSM39331	c.4031C>T	p.P1344L	Substitution - Missense	Skin
COSM3630086	c.3982T>C	p.L1328L	Substitution - coding silent	Skin
COSM1446052	c.3675G>A	p.M1225I	Substitution - Missense	Large_intestine
COSM1081853	c.3753C>T	p.F1251F	Substitution - coding silent	Endometrium
COSM1081871	c.1068G>T	p.E356D	Substitution - Missense	Endometrium
COSM5564627	c.4910G>C	p.R1637T	Substitution - Missense	Prostate
COSM4714053	c.190G>A	p.V64M	Substitution - Missense	Large_intestine
COSM3430899	c.3928C>T	p.R1310C	Substitution - Missense	Skin
COSM1081846	c.4486G>A	p.G1496S	Substitution - Missense	Endometrium
COSM4636497	c.1833T>C	p.N611N	Substitution - coding silent	Large_intestine
COSM246568	c.5054A>C	p.E1685A	Substitution - Missense	Prostate
COSM4609928	c.1911C>A	p.N637K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1081848	c.4382A>C	p.K1461T	Substitution - Missense	Endometrium
COSM269879	c.3288T>C	p.P1096P	Substitution - coding silent	Breast
COSM3374386	c.2095C>T	p.R699W	Substitution - Missense	Thyroid
COSM4426335	c.5052T>C	p.D1684D	Substitution - coding silent	Oesophagus
COSM1081861	c.3182C>T	p.A1061V	Substitution - Missense	Endometrium
COSM389580	c.1987G>T	p.V663F	Substitution - Missense	Lung
COSM484379	c.4792T>C	p.S1598P	Substitution - Missense	Kidney
COSM4931429	c.433A>T	p.S145C	Substitution - Missense	Liver
COSM743052	c.2202-3C>T	p.?	Unknown	Lung
COSM3762194	c.3278T>C	p.L1093P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5996591	c.2935C>T	p.R979W	Substitution - Missense	Prostate
COSM743054	c.3424G>T	p.G1142C	Substitution - Missense	Lung
COSM5588631	c.2169G>T	p.V723V	Substitution - coding silent	Skin
COSM5466926	c.2467G>A	p.E823K	Substitution - Missense	Large_intestine
COSM289477	c.3326A>C	p.N1109T	Substitution - Missense	Large_intestine
COSM283997	c.2755G>T	p.E919*	Substitution - Nonsense	Large_intestine
COSM4498378	c.5194C>T	p.P1732S	Substitution - Missense	Skin
COSM1081868	c.1330A>C	p.N444H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4883931	c.2923G>A	p.V975I	Substitution - Missense	Upper_aerodigestive_tract
COSM1446053	c.3148G>A	p.D1050N	Substitution - Missense	Large_intestine
COSM3875677	c.1406T>C	p.V469A	Substitution - Missense	Stomach
COSM3875675	c.1910A>C	p.N637T	Substitution - Missense	Stomach
COSM125342	c.5401A>G	p.T1801A	Substitution - Missense	Upper_aerodigestive_tract
COSM5919067	c.1083G>C	p.L361F	Substitution - Missense	Skin
COSM4880444	c.4155C>T	p.V1385V	Substitution - coding silent	Prostate
COSM1081870	c.1136G>T	p.R379M	Substitution - Missense	Endometrium
COSM3875676	c.1824C>T	p.G608G	Substitution - coding silent	Stomach
COSM1568251	c.4081A>G	p.M1361V	Substitution - Missense	Large_intestine
COSM4635435	c.1613T>C	p.L538P	Substitution - Missense	Large_intestine
COSM3831101	c.4513C>T	p.R1505*	Substitution - Nonsense	Breast
COSM5734595	c.1511C>G	p.S504C	Substitution - Missense	Pancreas
COSM743053	c.2873C>A	p.P958Q	Substitution - Missense	Lung
COSM4970520	c.5227C>T	p.R1743*	Substitution - Nonsense	Central_nervous_system
COSM5915567	c.2440A>T	p.N814Y	Substitution - Missense	Skin
COSM5632437	c.2905C>T	p.Q969*	Substitution - Nonsense	Oesophagus
COSM1081873	c.822+1G>A	p.?	Unknown	Endometrium
COSM39331	c.4031C>T	p.P1344L	Substitution - Missense	Central_nervous_system
COSM1081840	c.5185C>A	p.L1729I	Substitution - Missense	Endometrium
COSM5654762	c.153G>C	p.W51C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5880233	c.4381A>G	p.K1461E	Substitution - Missense	Skin
COSM3176010	c.721G>A	p.A241T	Substitution - Missense	Large_intestine
COSM5428677	c.709A>T	p.N237Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1621962	c.4643C>G	p.S1548C	Substitution - Missense	Liver
COSM4758021	c.3893G>A	p.R1298Q	Substitution - Missense	Stomach
COSM1446059	c.487C>T	p.R163*	Substitution - Nonsense	Large_intestine
COSM1081844	c.4790C>T	p.A1597V	Substitution - Missense	Large_intestine
COSM283998	c.2390G>A	p.R797H	Substitution - Missense	Large_intestine
COSM4978221	c.1402G>T	p.E468*	Substitution - Nonsense	Oesophagus
COSM3831102	c.2375A>T	p.N792I	Substitution - Missense	Breast
COSM1187092	c.1712A>G	p.N571S	Substitution - Missense	Lung
COSM4186138	c.1937T>C	p.M646T	Substitution - Missense	Kidney
COSM3875670	c.3728G>A	p.S1243N	Substitution - Missense	Upper_aerodigestive_tract
COSM82288	c.4746A>G	p.E1582E	Substitution - coding silent	Ovary
COSM3737224	c.610_611insACTA	p.C205fs*1	Insertion - Frameshift	Soft_tissue
COSM4880462	c.3180T>C	p.D1060D	Substitution - coding silent	Prostate
COSM1446051	c.3783-2A>G	p.?	Unknown	Large_intestine
COSM5996876	c.3084T>C	p.P1028P	Substitution - coding silent	Prostate
COSM3430899	c.3928C>T	p.R1310C	Substitution - Missense	Stomach
COSM276731	c.3838T>G	p.L1280V	Substitution - Missense	Large_intestine
COSM283996	c.5131C>T	p.R1711C	Substitution - Missense	Large_intestine
COSM32396	c.1405G>A	p.V469I	Substitution - Missense	Large_intestine
COSM6012386	c.2201G>A	p.S734N	Substitution - Missense	Skin
COSM3381670	c.4999C>T	p.Q1667*	Substitution - Nonsense	Pancreas
COSM4988896	c.5284T>C	p.S1762P	Substitution - Missense	Soft_tissue
COSM3922200	c.1250G>A	p.G417E	Substitution - Missense	Skin
COSM1319061	c.3947_3948insA	p.Y1316fs*1	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4850889	c.4427C>T	p.S1476F	Substitution - Missense	Cervix
COSM5811707	c.682A>C	p.I228L	Substitution - Missense	Liver
COSM1220393	c.1421C>T	p.P474L	Substitution - Missense	Large_intestine
COSM4887500	c.3952A>G	p.I1318V	Substitution - Missense	Upper_aerodigestive_tract
COSM4988896	c.5284T>C	p.S1762P	Substitution - Missense	Soft_tissue
COSM3175975	c.3148G>T	p.D1050Y	Substitution - Missense	Large_intestine
COSM5476711	c.1169G>A	p.R390H	Substitution - Missense	Large_intestine
COSM219580	c.1285A>G	p.M429V	Substitution - Missense	Breast
COSM743058	c.5046C>G	p.I1682M	Substitution - Missense	Lung
COSM5450284	c.4706G>C	p.G1569A	Substitution - Missense	Large_intestine
COSM4438985	c.1013C>T	p.T338M	Substitution - Missense	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for PHIP.

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8WWQ0	641	S	Phosphoserine	-	No	None detected
Q8WWQ0	659	S	Phosphoserine	-	No	None detected
Q8WWQ0	674	S	Phosphoserine	-	No	None detected
Q8WWQ0	677	S	Phosphoserine	-	No	None detected
Q8WWQ0	683	S	Phosphoserine	-	No	None detected
Q8WWQ0	692	S	Phosphoserine	-	No	None detected
Q8WWQ0	879	S	Phosphoserine	-	No	None detected
Q8WWQ0	880	S	Phosphoserine	-	No	None detected
Q8WWQ0	881	S	Phosphoserine	-	No	None detected
Q8WWQ0	911	S	Phosphoserine	-	No	None detected
Q8WWQ0	1281	S	Phosphoserine	-	No	None detected
Q8WWQ0	1283	S	Phosphoserine	-	No	None detected
Q8WWQ0	1296	S	Phosphoserine	-	No	None detected
Q8WWQ0	1315	S	Phosphoserine	-	No	None detected
Q8WWQ0	1359	T	Phosphothreonine	-	No	None detected
Q8WWQ0	1405	S	Phosphoserine	-	No	None detected
Q8WWQ0	1479	S	Phosphoserine	-	No	None detected
Q8WWQ0	1497	K	N6-acetyllysine	-	No	None detected
Q8WWQ0	1525	S	Phosphoserine	-	No	None detected
Q8WWQ0	1533	K	N6-acetyllysine	-	No	None detected
Q8WWQ0	1560	S	Phosphoserine	-	No	None detected
Q8WWQ0	1651	S	Phosphoserine	-	No	None detected
Q8WWQ0	1762	S	Phosphoserine	-	No	None detected
Q8WWQ0	1783	S	Phosphoserine	-	Yes	p.S1783Y (cancer: LUSC)

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.061	5.718	-0.295	0.0845	NS
BRCA	Breast invasive carcinoma	112	1100	6.759	6.391	-0.332	3.67e-07	NS
CESC	Cervical and endocervical cancers	3	306	5.84	6.158	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.166	5.364	0.011	0.939	NS
ESCA	Esophageal carcinoma	11	185	7.042	7.067	0.098	0.638	NS
GBM	Glioblastoma multiforme	5	166	5.499	5.179	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.583	5.49	0.048	0.674	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.056	6.031	0.023	0.751	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.58	5.607	-0.029	0.838	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.32	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.572	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.91	4.313	0.322	0.00247	NS
LUAD	Lung adenocarcinoma	59	517	6.116	5.906	-0.129	0.13	NS
LUSC	Lung squamous cell carcinoma	51	501	5.86	5.982	0.096	0.262	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.211	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.715	5.586	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.895	6.194	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.033	5.804	-0.305	0.0104	NS
READ	Rectum adenocarcinoma	10	167	5.492	5.354	-0.328	0.344	NS
SARC	Sarcoma	2	263	5.124	5.447	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.449	5.539	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.221	6.793	0.484	1.27e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.995	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.043	5.959	-0.093	0.137	NS
THYM	Thymoma	2	120	6.403	6.054	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.248	5.864	-0.424	0.000375	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.9
Autonomic ganglia	CHP212	9.7
Autonomic ganglia	IMR32	10.6
Autonomic ganglia	KELLY	10.4
Autonomic ganglia	KPNRTBM1	10.6
Autonomic ganglia	KPNSI9S	9.3
Autonomic ganglia	KPNYN	10.6
Autonomic ganglia	MHHNB11	10.9
Autonomic ganglia	NB1	10.2
Autonomic ganglia	NH6	10.2
Autonomic ganglia	SHSY5Y	10.4
Autonomic ganglia	SIMA	10.2
Autonomic ganglia	SKNAS	9.7
Autonomic ganglia	SKNBE2	10.3
Autonomic ganglia	SKNDZ	10.3
Autonomic ganglia	SKNFI	9
Autonomic ganglia	SKNSH	9.1
Biliary tract	HUCCT1	8.6
Biliary tract	HUH28	9
Biliary tract	SNU1079	9.2
Biliary tract	SNU1196	9.1
Biliary tract	SNU245	8.9
Biliary tract	SNU308	9.1
Biliary tract	SNU478	9.8
Bone	143B	9.5
Bone	A673	9.6
Bone	CADOES1	9.9
Bone	CAL78	9.7
Bone	G292CLONEA141B1	9.4
Bone	HOS	9.9
Bone	HS706T	9.3
Bone	HS737T	8.6
Bone	HS819T	8.3
Bone	HS821T	8.8
Bone	HS822T	8.3
Bone	HS863T	8.9
Bone	HS870T	9.1
Bone	HS888T	9.4
Bone	MG63	9.6
Bone	MHHES1	10
Bone	OUMS27	9.1
Bone	RDES	9.8
Bone	SJSA1	9.1
Bone	SKES1	10
Bone	SKNMC	10.2
Bone	SW1353	8.9
Bone	T173	8.7
Bone	TC71	9.7
Bone	U2OS	9.1
Breast	AU565	9.7
Breast	BT20	9.7
Breast	BT474	10.1
Breast	BT483	9.2
Breast	BT549	9.5
Breast	CAL120	9.4
Breast	CAL148	9.5
Breast	CAL51	10.7
Breast	CAL851	9.4
Breast	CAMA1	9.1
Breast	DU4475	9.8
Breast	EFM192A	9.5
Breast	EFM19	9.9
Breast	EVSAT	9.8
Breast	HCC1143	10.4
Breast	HCC1187	9.8
Breast	HCC1395	9.8
Breast	HCC1419	10.2
Breast	HCC1428	9.2
Breast	HCC1500	9.7
Breast	HCC1569	9
Breast	HCC1599	10
Breast	HCC1806	9.6
Breast	HCC1937	9.8
Breast	HCC1954	10.1
Breast	HCC202	8.3
Breast	HCC2157	8.9
Breast	HCC2218	9.6
Breast	HCC38	9.1
Breast	HCC70	9.3
Breast	HDQP1	9.7
Breast	HMC18	9.5
Breast	HS274T	9.1
Breast	HS281T	8.6
Breast	HS343T	8.9
Breast	HS578T	9
Breast	HS606T	8.8
Breast	HS739T	8.7
Breast	HS742T	8.1
Breast	JIMT1	8.3
Breast	KPL1	9.5
Breast	MCF7	9.8
Breast	MDAMB134VI	10.2
Breast	MDAMB157	9.8
Breast	MDAMB175VII	9.1
Breast	MDAMB231	9
Breast	MDAMB361	10.1
Breast	MDAMB415	10.1
Breast	MDAMB436	9.6
Breast	MDAMB453	10.2
Breast	MDAMB468	10.4
Breast	SKBR3	9.6
Breast	T47D	9.4
Breast	UACC812	10
Breast	UACC893	10.3
Breast	YMB1	9.7
Breast	ZR751	9.7
Breast	ZR7530	9.1
Central nervous system	1321N1	9.6
Central nervous system	42MGBA	9.2
Central nervous system	8MGBA	8.8
Central nervous system	A172	9.2
Central nervous system	AM38	9.1
Central nervous system	BECKER	9.4
Central nervous system	CAS1	8.7
Central nervous system	CCFSTTG1	9.4
Central nervous system	D283MED	9.8
Central nervous system	D341MED	10.2
Central nervous system	DAOY	10.2
Central nervous system	DBTRG05MG	8.3
Central nervous system	DKMG	9.7
Central nervous system	GAMG	9.2
Central nervous system	GB1	9.2
Central nervous system	GI1	9.9
Central nervous system	GMS10	9.6
Central nervous system	GOS3	8.3
Central nervous system	H4	9.1
Central nervous system	HS683	9.5
Central nervous system	KALS1	9.7
Central nervous system	KG1C	8.6
Central nervous system	KNS42	10.2
Central nervous system	KNS60	9.4
Central nervous system	KNS81	9
Central nervous system	KS1	9.9
Central nervous system	LN18	9.2
Central nervous system	LN229	9.9
Central nervous system	M059K	9.6
Central nervous system	MOGGCCM	9.2
Central nervous system	MOGGUVW	9.7
Central nervous system	NMCG1	9.2
Central nervous system	ONS76	9.9
Central nervous system	SF126	9.2
Central nervous system	SF295	9
Central nervous system	SNB19	9.9
Central nervous system	SNU1105	9.1
Central nervous system	SNU201	8.6
Central nervous system	SNU466	7.6
Central nervous system	SNU489	8
Central nervous system	SNU626	9
Central nervous system	SNU738	8.7
Central nervous system	SW1088	9.2
Central nervous system	SW1783	9.3
Central nervous system	T98G	8.3
Central nervous system	TM31	9.1
Central nervous system	U118MG	9.5
Central nervous system	U138MG	9
Central nervous system	U251MG	9.7
Central nervous system	U87MG	8.1
Central nervous system	YH13	8.9
Central nervous system	YKG1	9.8
Endometrium	AN3CA	10.2
Endometrium	COLO684	9.6
Endometrium	EFE184	9.4
Endometrium	EN	9.5
Endometrium	ESS1	9.8
Endometrium	HEC108	10.5
Endometrium	HEC151	9.3
Endometrium	HEC1A	10.2
Endometrium	HEC1B	10.1
Endometrium	HEC251	10.8
Endometrium	HEC265	9.8
Endometrium	HEC50B	9.3
Endometrium	HEC59	9.2
Endometrium	HEC6	10.1
Endometrium	ISHIKAWAHERAKLIO02ER	10.2
Endometrium	JHUEM1	10.2
Endometrium	JHUEM2	10.7
Endometrium	JHUEM3	9.8
Endometrium	KLE	9.3
Endometrium	MFE280	10.1
Endometrium	MFE296	9.7
Endometrium	MFE319	9.9
Endometrium	RL952	10.1
Endometrium	SNGM	10.1
Endometrium	SNU1077	9.5
Endometrium	SNU685	9
Endometrium	TEN	9.8
Haematopoietic and lymphoid	697	9.1
Haematopoietic and lymphoid	A3KAW	9.9
Haematopoietic and lymphoid	A4FUK	10.7
Haematopoietic and lymphoid	ALLSIL	9.9
Haematopoietic and lymphoid	AML193	10.4
Haematopoietic and lymphoid	AMO1	9.6
Haematopoietic and lymphoid	BCP1	9.5
Haematopoietic and lymphoid	BDCM	9.7
Haematopoietic and lymphoid	BL41	9.9
Haematopoietic and lymphoid	BL70	10.1
Haematopoietic and lymphoid	BV173	10.9
Haematopoietic and lymphoid	CA46	10
Haematopoietic and lymphoid	CI1	9.8
Haematopoietic and lymphoid	CMK115	10.1
Haematopoietic and lymphoid	CMK86	10.3
Haematopoietic and lymphoid	CMK	9.6
Haematopoietic and lymphoid	CMLT1	10.1
Haematopoietic and lymphoid	COLO775	9.3
Haematopoietic and lymphoid	DAUDI	10.1
Haematopoietic and lymphoid	DB	9.8
Haematopoietic and lymphoid	DEL	10.2
Haematopoietic and lymphoid	DND41	9.5
Haematopoietic and lymphoid	DOHH2	10
Haematopoietic and lymphoid	EB1	9.8
Haematopoietic and lymphoid	EB2	9.9
Haematopoietic and lymphoid	EHEB	10.2
Haematopoietic and lymphoid	EJM	9.3
Haematopoietic and lymphoid	EM2	10.7
Haematopoietic and lymphoid	EOL1	10.5
Haematopoietic and lymphoid	F36P	9.3
Haematopoietic and lymphoid	GA10	10.1
Haematopoietic and lymphoid	GDM1	9.9
Haematopoietic and lymphoid	GRANTA519	10.2
Haematopoietic and lymphoid	HDLM2	10.8
Haematopoietic and lymphoid	HDMYZ	9.4
Haematopoietic and lymphoid	HEL9217	9.9
Haematopoietic and lymphoid	HEL	10.1
Haematopoietic and lymphoid	HH	10.1
Haematopoietic and lymphoid	HL60	10.6
Haematopoietic and lymphoid	HPBALL	10.1
Haematopoietic and lymphoid	HS604T	8.3
Haematopoietic and lymphoid	HS611T	9.4
Haematopoietic and lymphoid	HS616T	8.5
Haematopoietic and lymphoid	HS751T	9.1
Haematopoietic and lymphoid	HT	10.5
Haematopoietic and lymphoid	HTK	9.7
Haematopoietic and lymphoid	HUNS1	9.2
Haematopoietic and lymphoid	HUT102	10.6
Haematopoietic and lymphoid	HUT78	9.6
Haematopoietic and lymphoid	JEKO1	8.5
Haematopoietic and lymphoid	JK1	10.2
Haematopoietic and lymphoid	JM1	10.4
Haematopoietic and lymphoid	JURKAT	10
Haematopoietic and lymphoid	JURLMK1	10
Haematopoietic and lymphoid	JVM2	10.4
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	9.4
Haematopoietic and lymphoid	KARPAS299	10.3
Haematopoietic and lymphoid	KARPAS422	10.2
Haematopoietic and lymphoid	KARPAS620	10.2
Haematopoietic and lymphoid	KASUMI1	10.4
Haematopoietic and lymphoid	KASUMI2	9.4
Haematopoietic and lymphoid	KASUMI6	10
Haematopoietic and lymphoid	KCL22	10
Haematopoietic and lymphoid	KE37	10.6
Haematopoietic and lymphoid	KE97	9.5
Haematopoietic and lymphoid	KG1	10.1
Haematopoietic and lymphoid	KHM1B	9.5
Haematopoietic and lymphoid	KIJK	10
Haematopoietic and lymphoid	KMH2	10
Haematopoietic and lymphoid	KMM1	9.6
Haematopoietic and lymphoid	KMS11	9.4
Haematopoietic and lymphoid	KMS12BM	10.7
Haematopoietic and lymphoid	KMS18	9.6
Haematopoietic and lymphoid	KMS20	10.3
Haematopoietic and lymphoid	KMS21BM	9.7
Haematopoietic and lymphoid	KMS26	9.5
Haematopoietic and lymphoid	KMS27	8.8
Haematopoietic and lymphoid	KMS28BM	11.2
Haematopoietic and lymphoid	KMS34	10.5
Haematopoietic and lymphoid	KO52	10
Haematopoietic and lymphoid	KOPN8	9.4
Haematopoietic and lymphoid	KU812	10.6
Haematopoietic and lymphoid	KYO1	9.1
Haematopoietic and lymphoid	L1236	9.7
Haematopoietic and lymphoid	L363	10.1
Haematopoietic and lymphoid	L428	10.9
Haematopoietic and lymphoid	L540	9.5
Haematopoietic and lymphoid	LAMA84	10.7
Haematopoietic and lymphoid	LOUCY	10.7
Haematopoietic and lymphoid	LP1	9.2
Haematopoietic and lymphoid	M07E	9.9
Haematopoietic and lymphoid	MC116	10
Haematopoietic and lymphoid	ME1	8
Haematopoietic and lymphoid	MEC1	10.1
Haematopoietic and lymphoid	MEC2	8.8
Haematopoietic and lymphoid	MEG01	10.3
Haematopoietic and lymphoid	MHHCALL2	10.4
Haematopoietic and lymphoid	MHHCALL3	9.6
Haematopoietic and lymphoid	MHHCALL4	10.2
Haematopoietic and lymphoid	MINO	10
Haematopoietic and lymphoid	MJ	9.7
Haematopoietic and lymphoid	MM1S	10.2
Haematopoietic and lymphoid	MOLM13	10.9
Haematopoietic and lymphoid	MOLM16	9.3
Haematopoietic and lymphoid	MOLM6	9.6
Haematopoietic and lymphoid	MOLP2	9.2
Haematopoietic and lymphoid	MOLP8	10.1
Haematopoietic and lymphoid	MOLT13	10.5
Haematopoietic and lymphoid	MOLT16	9.6
Haematopoietic and lymphoid	MOLT4	9.8
Haematopoietic and lymphoid	MONOMAC1	10.3
Haematopoietic and lymphoid	MONOMAC6	10.9
Haematopoietic and lymphoid	MOTN1	9.7
Haematopoietic and lymphoid	MUTZ5	9.5
Haematopoietic and lymphoid	MV411	10.4
Haematopoietic and lymphoid	NALM19	9.9
Haematopoietic and lymphoid	NALM1	10.2
Haematopoietic and lymphoid	NALM6	10.3
Haematopoietic and lymphoid	NAMALWA	10
Haematopoietic and lymphoid	NB4	10.3
Haematopoietic and lymphoid	NCIH929	11.1
Haematopoietic and lymphoid	NCO2	10.9
Haematopoietic and lymphoid	NOMO1	9.9
Haematopoietic and lymphoid	NUDHL1	8.5
Haematopoietic and lymphoid	NUDUL1	10.1
Haematopoietic and lymphoid	OCIAML2	10.5
Haematopoietic and lymphoid	OCIAML3	9.5
Haematopoietic and lymphoid	OCIAML5	10
Haematopoietic and lymphoid	OCILY10	10.3
Haematopoietic and lymphoid	OCILY19	9.3
Haematopoietic and lymphoid	OCILY3	10.7
Haematopoietic and lymphoid	OCIM1	10.4
Haematopoietic and lymphoid	OPM2	10.5
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	9.5
Haematopoietic and lymphoid	P3HR1	9.9
Haematopoietic and lymphoid	PCM6	8.3
Haematopoietic and lymphoid	PEER	9.9
Haematopoietic and lymphoid	PF382	10.8
Haematopoietic and lymphoid	PFEIFFER	9.8
Haematopoietic and lymphoid	PL21	10.8
Haematopoietic and lymphoid	RAJI	9.9
Haematopoietic and lymphoid	RCHACV	9.3
Haematopoietic and lymphoid	REC1	9.3
Haematopoietic and lymphoid	REH	10
Haematopoietic and lymphoid	RI1	8.3
Haematopoietic and lymphoid	RL	9.6
Haematopoietic and lymphoid	RPMI8226	9.5
Haematopoietic and lymphoid	RPMI8402	9.4
Haematopoietic and lymphoid	RS411	10.2
Haematopoietic and lymphoid	SEM	10.6
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	9.8
Haematopoietic and lymphoid	SKM1	10
Haematopoietic and lymphoid	SKMM2	10.8
Haematopoietic and lymphoid	SR786	10.7
Haematopoietic and lymphoid	ST486	9.8
Haematopoietic and lymphoid	SUDHL10	8.5
Haematopoietic and lymphoid	SUDHL1	9.8
Haematopoietic and lymphoid	SUDHL4	8.7
Haematopoietic and lymphoid	SUDHL5	9.2
Haematopoietic and lymphoid	SUDHL6	9.9
Haematopoietic and lymphoid	SUDHL8	9.7
Haematopoietic and lymphoid	SUPB15	9.8
Haematopoietic and lymphoid	SUPHD1	9.7
Haematopoietic and lymphoid	SUPM2	10.5
Haematopoietic and lymphoid	SUPT11	10
Haematopoietic and lymphoid	SUPT1	10.4
Haematopoietic and lymphoid	TALL1	10.8
Haematopoietic and lymphoid	TF1	10.4
Haematopoietic and lymphoid	THP1	11.4
Haematopoietic and lymphoid	TO175T	9
Haematopoietic and lymphoid	TOLEDO	9.6
Haematopoietic and lymphoid	U266B1	9.7
Haematopoietic and lymphoid	U937	9.6
Haematopoietic and lymphoid	UT7	10.9
Haematopoietic and lymphoid	WSUDLCL2	9
Kidney	769P	9.4
Kidney	786O	8.9
Kidney	A498	7.9
Kidney	A704	9.6
Kidney	ACHN	9.2
Kidney	BFTC909	9.8
Kidney	CAKI1	8.8
Kidney	CAKI2	8.8
Kidney	CAL54	9.1
Kidney	KMRC1	9.8
Kidney	KMRC20	9.5
Kidney	KMRC2	9.4
Kidney	KMRC3	8
Kidney	OSRC2	8.8
Kidney	RCC10RGB	9
Kidney	SNU1272	9
Kidney	SNU349	8.5
Kidney	TUHR10TKB	8.6
Kidney	TUHR14TKB	8.9
Kidney	TUHR4TKB	9
Kidney	VMRCRCW	8.6
Kidney	VMRCRCZ	10
Large intestine	C2BBE1	9.5
Large intestine	CCK81	9.5
Large intestine	CL11	9
Large intestine	CL14	9.8
Large intestine	CL34	9.5
Large intestine	CL40	8.6
Large intestine	COLO205	8.6
Large intestine	COLO320	9.3
Large intestine	COLO678	9.6
Large intestine	CW2	9.1
Large intestine	DLD1	9.5
Large intestine	GP2D	10.2
Large intestine	HCC56	8.8
Large intestine	HCT116	9.3
Large intestine	HCT15	9.9
Large intestine	HS675T	8.5
Large intestine	HS698T	8.9
Large intestine	HT115	9.5
Large intestine	HT29	9
Large intestine	HT55	9.6
Large intestine	KM12	10.1
Large intestine	LOVO	9.3
Large intestine	LS1034	9.2
Large intestine	LS123	9.7
Large intestine	LS180	9.3
Large intestine	LS411N	9.8
Large intestine	LS513	9.2
Large intestine	MDST8	8.1
Large intestine	NCIH508	9.1
Large intestine	NCIH716	9.1
Large intestine	NCIH747	10.1
Large intestine	OUMS23	9.8
Large intestine	RCM1	9.5
Large intestine	RKO	10
Large intestine	SKCO1	10.2
Large intestine	SNU1040	9.1
Large intestine	SNU1197	9
Large intestine	SNU175	10.1
Large intestine	SNU283	9
Large intestine	SNU407	10.3
Large intestine	SNU503	9.2
Large intestine	SNU61	8.8
Large intestine	SNU81	10.3
Large intestine	SNUC1	8.7
Large intestine	SNUC2A	10.4
Large intestine	SNUC4	9.4
Large intestine	SNUC5	10.7
Large intestine	SW1116	8.9
Large intestine	SW1417	9.3
Large intestine	SW1463	9.2
Large intestine	SW403	9.2
Large intestine	SW480	9.5
Large intestine	SW48	10.2
Large intestine	SW620	9.7
Large intestine	SW837	9.1
Large intestine	SW948	9.9
Large intestine	T84	9.5
Liver	ALEXANDERCELLS	9.7
Liver	C3A	9
Liver	HEP3B217	10.3
Liver	HEPG2	9
Liver	HLE	9.2
Liver	HLF	9.5
Liver	HUH1	9.7
Liver	HUH6	9.5
Liver	HUH7	9.6
Liver	JHH1	9.4
Liver	JHH2	9
Liver	JHH4	9.2
Liver	JHH5	9.4
Liver	JHH6	9.6
Liver	JHH7	9.6
Liver	LI7	9.5
Liver	PLCPRF5	9.6
Liver	SKHEP1	8.8
Liver	SNU182	9.3
Liver	SNU387	9.4
Liver	SNU398	10.4
Liver	SNU423	9.7
Liver	SNU449	9.2
Liver	SNU475	9.4
Liver	SNU761	9.3
Liver	SNU878	8.9
Liver	SNU886	9.3
Lung	A549	9
Lung	ABC1	10.3
Lung	BEN	9.3
Lung	CAL12T	8.4
Lung	CALU1	9.5
Lung	CALU3	10.2
Lung	CALU6	9.4
Lung	CHAGOK1	10.1
Lung	COLO668	9.3
Lung	COLO699	9.5
Lung	CORL105	8.6
Lung	CORL23	9.1
Lung	CORL24	10.6
Lung	CORL279	10.6
Lung	CORL311	10.3
Lung	CORL47	9.3
Lung	CORL51	9.9
Lung	CORL88	11.1
Lung	CORL95	10
Lung	CPCN	10.6
Lung	DMS114	10.1
Lung	DMS153	11.4
Lung	DMS273	9.2
Lung	DMS454	9.2
Lung	DMS53	9.4
Lung	DMS79	11.7
Lung	DV90	9.3
Lung	EBC1	8.9
Lung	EPLC272H	9.9
Lung	HARA	9.4
Lung	HCC1171	9.7
Lung	HCC1195	7.5
Lung	HCC15	9.3
Lung	HCC2279	8.9
Lung	HCC2935	9.5
Lung	HCC33	10.7
Lung	HCC366	9.4
Lung	HCC4006	10.1
Lung	HCC44	7.9
Lung	HCC78	9.8
Lung	HCC827	9.4
Lung	HCC95	8.6
Lung	HLC1	8.7
Lung	HLFA	8.9
Lung	HS229T	9.3
Lung	HS618T	8.8
Lung	IALM	8.8
Lung	KNS62	8.7
Lung	LC1F	9.9
Lung	LC1SQSF	9.9
Lung	LCLC103H	8.8
Lung	LCLC97TM1	9.7
Lung	LK2	10
Lung	LOUNH91	9.1
Lung	LU65	9.5
Lung	LU99	10.1
Lung	LUDLU1	8.9
Lung	LXF289	9.4
Lung	MORCPR	8.8
Lung	NCIH1048	10.8
Lung	NCIH1092	10.4
Lung	NCIH1105	11.5
Lung	NCIH1155	9.9
Lung	NCIH1184	11.9
Lung	NCIH1299	10.1
Lung	NCIH1339	9.8
Lung	NCIH1341	9.8
Lung	NCIH1355	9.5
Lung	NCIH1373	9.4
Lung	NCIH1385	10.3
Lung	NCIH1395	8.9
Lung	NCIH1435	9.1
Lung	NCIH1436	11.1
Lung	NCIH1437	9.4
Lung	NCIH146	10.2
Lung	NCIH1563	8.5
Lung	NCIH1568	9.5
Lung	NCIH1573	8.9
Lung	NCIH1581	9.9
Lung	NCIH1618	11.1
Lung	NCIH1623	8.8
Lung	NCIH1648	9.4
Lung	NCIH1650	8.8
Lung	NCIH1651	9.4
Lung	NCIH1666	8.8
Lung	NCIH1693	10.4
Lung	NCIH1694	10.4
Lung	NCIH1703	9.8
Lung	NCIH1734	9.2
Lung	NCIH1755	9.5
Lung	NCIH1781	10.8
Lung	NCIH1792	8.9
Lung	NCIH1793	8.9
Lung	NCIH1836	10.1
Lung	NCIH1838	9.5
Lung	NCIH1869	9.1
Lung	NCIH1876	11.2
Lung	NCIH1915	9.3
Lung	NCIH1930	9.9
Lung	NCIH1944	10
Lung	NCIH1963	11.1
Lung	NCIH196	9.4
Lung	NCIH1975	8.8
Lung	NCIH2009	9.6
Lung	NCIH2023	8.8
Lung	NCIH2029	10.4
Lung	NCIH2030	9.7
Lung	NCIH2066	10.7
Lung	NCIH2081	10.9
Lung	NCIH2085	9.2
Lung	NCIH2087	9.2
Lung	NCIH209	11
Lung	NCIH2106	10.7
Lung	NCIH2110	10.1
Lung	NCIH211	10.5
Lung	NCIH2122	9.2
Lung	NCIH2126	8.8
Lung	NCIH2141	11.2
Lung	NCIH2170	9.8
Lung	NCIH2171	10.1
Lung	NCIH2172	9.6
Lung	NCIH2196	10.4
Lung	NCIH2227	10.1
Lung	NCIH2228	8.9
Lung	NCIH226	9.5
Lung	NCIH2286	9.2
Lung	NCIH2291	9.5
Lung	NCIH2342	10.2
Lung	NCIH2347	9
Lung	NCIH23	10.3
Lung	NCIH2405	9.6
Lung	NCIH2444	9.3
Lung	NCIH292	9.8
Lung	NCIH322	9.9
Lung	NCIH3255	10
Lung	NCIH358	9.7
Lung	NCIH441	9.2
Lung	NCIH446	9.8
Lung	NCIH460	9.3
Lung	NCIH510	10
Lung	NCIH520	10
Lung	NCIH522	9.7
Lung	NCIH524	9.9
Lung	NCIH526	10
Lung	NCIH596	9.6
Lung	NCIH647	9.8
Lung	NCIH650	9.2
Lung	NCIH661	10.5
Lung	NCIH69	11.4
Lung	NCIH727	9.5
Lung	NCIH810	10.2
Lung	NCIH82	9.5
Lung	NCIH838	9.8
Lung	NCIH841	10.5
Lung	NCIH854	9.5
Lung	NCIH889	9.5
Lung	PC14	9.2
Lung	RERFLCAD1	9.9
Lung	RERFLCAD2	9.4
Lung	RERFLCAI	9.7
Lung	RERFLCKJ	9.4
Lung	RERFLCMS	9.1
Lung	RERFLCSQ1	9.1
Lung	SBC5	10.1
Lung	SCLC21H	10.9
Lung	SHP77	9.9
Lung	SKLU1	8.4
Lung	SKMES1	8.9
Lung	SQ1	8.5
Lung	SW1271	9.6
Lung	SW1573	10
Lung	SW900	8.3
Lung	VMRCLCD	10.2
Lung	VMRCLCP	10
Oesophagus	COLO680N	9.8
Oesophagus	ECGI10	9.4
Oesophagus	KYSE140	9.6
Oesophagus	KYSE150	9.1
Oesophagus	KYSE180	9.8
Oesophagus	KYSE270	9.4
Oesophagus	KYSE30	9.2
Oesophagus	KYSE410	8.7
Oesophagus	KYSE450	9
Oesophagus	KYSE510	10.3
Oesophagus	KYSE520	9.1
Oesophagus	KYSE70	8.6
Oesophagus	OE19	8.7
Oesophagus	OE33	10.7
Oesophagus	TE10	10
Oesophagus	TE11	9.4
Oesophagus	TE14	10.5
Oesophagus	TE15	9.3
Oesophagus	TE1	9.6
Oesophagus	TE4	9.4
Oesophagus	TE5	9.9
Oesophagus	TE6	10.1
Oesophagus	TE8	9.7
Oesophagus	TE9	9.6
Oesophagus	TT	9.3
Ovary	59M	9.1
Ovary	A2780	10.4
Ovary	CAOV3	9.8
Ovary	CAOV4	10.2
Ovary	COLO704	10.4
Ovary	COV318	9.5
Ovary	COV362	9.6
Ovary	COV434	9.9
Ovary	COV504	10.3
Ovary	COV644	9.9
Ovary	EFO21	10.1
Ovary	EFO27	9.3
Ovary	ES2	9.7
Ovary	FUOV1	10
Ovary	HEYA8	9.4
Ovary	HS571T	8.6
Ovary	IGROV1	9.5
Ovary	JHOC5	9
Ovary	JHOM1	9.7
Ovary	JHOM2B	9.6
Ovary	JHOS2	10
Ovary	JHOS4	10
Ovary	KURAMOCHI	10.9
Ovary	MCAS	9.3
Ovary	NIHOVCAR3	10.1
Ovary	OAW28	10.4
Ovary	OAW42	9.3
Ovary	OC314	9.7
Ovary	OC316	9.6
Ovary	ONCODG1	10.2
Ovary	OV56	9
Ovary	OV7	9.2
Ovary	OV90	10.3
Ovary	OVCAR4	9.7
Ovary	OVCAR8	10.5
Ovary	OVISE	9.3
Ovary	OVK18	8.6
Ovary	OVKATE	9.5
Ovary	OVMANA	10.5
Ovary	OVSAHO	9.9
Ovary	OVTOKO	9
Ovary	RMGI	8.6
Ovary	RMUGS	7.8
Ovary	SKOV3	9.9
Ovary	SNU119	9.7
Ovary	SNU840	9.1
Ovary	SNU8	9.6
Ovary	TOV112D	9.9
Ovary	TOV21G	10
Ovary	TYKNU	8.5
Pancreas	ASPC1	8.7
Pancreas	BXPC3	8.9
Pancreas	CAPAN1	9.2
Pancreas	CAPAN2	9.2
Pancreas	CFPAC1	8.9
Pancreas	DANG	9.4
Pancreas	HPAC	10.7
Pancreas	HPAFII	9.1
Pancreas	HS766T	9
Pancreas	HUPT3	8.8
Pancreas	HUPT4	9.7
Pancreas	KCIMOH1	9.8
Pancreas	KLM1	7.8
Pancreas	KP2	10
Pancreas	KP3	9.1
Pancreas	KP4	10.8
Pancreas	L33	10.8
Pancreas	MIAPACA2	10
Pancreas	PANC0203	9.2
Pancreas	PANC0213	9.9
Pancreas	PANC0327	9.3
Pancreas	PANC0403	9.2
Pancreas	PANC0504	9.3
Pancreas	PANC0813	9.6
Pancreas	PANC1005	10
Pancreas	PANC1	9.3
Pancreas	PATU8902	9.8
Pancreas	PATU8988S	9.3
Pancreas	PATU8988T	10.3
Pancreas	PK1	8.8
Pancreas	PK45H	9.2
Pancreas	PK59	9.7
Pancreas	PL45	9.9
Pancreas	PSN1	9.3
Pancreas	QGP1	9.6
Pancreas	SNU213	9.3
Pancreas	SNU324	9
Pancreas	SNU410	8.6
Pancreas	SU8686	10
Pancreas	SUIT2	9.4
Pancreas	SW1990	9.4
Pancreas	T3M4	8.8
Pancreas	TCCPAN2	9.5
Pancreas	YAPC	9.7
Pleura	ACCMESO1	8.7
Pleura	DM3	8.3
Pleura	ISTMES1	9.4
Pleura	ISTMES2	9.2
Pleura	JL1	9.5
Pleura	MPP89	9.3
Pleura	MSTO211H	9.4
Pleura	NCIH2052	8.5
Pleura	NCIH2452	10
Pleura	NCIH28	9.8
Prostate	22RV1	10.3
Prostate	DU145	9.3
Prostate	LNCAPCLONEFGC	9.5
Prostate	MDAPCA2B	9.4
Prostate	NCIH660	11.1
Prostate	PC3	9.4
Prostate	VCAP	9.3
Salivary gland	A253	9.8
Salivary gland	YD15	9.2
Skin	A101D	8.6
Skin	A2058	9.5
Skin	A375	9.1
Skin	C32	9
Skin	CHL1	9.6
Skin	CJM	9.6
Skin	COLO679	9.2
Skin	COLO741	8.6
Skin	COLO783	8.9
Skin	COLO792	6.6
Skin	COLO800	9.8
Skin	COLO818	9.6
Skin	COLO829	9.1
Skin	COLO849	9.8
Skin	G361	9.1
Skin	GRM	8
Skin	HMCB	10.1
Skin	HS294T	7.9
Skin	HS600T	8.7
Skin	HS688AT	8.6
Skin	HS695T	8.9
Skin	HS839T	8.9
Skin	HS852T	9
Skin	HS895T	8.7
Skin	HS934T	9.1
Skin	HS936T	9.4
Skin	HS939T	9.8
Skin	HS940T	8.4
Skin	HS944T	8.6
Skin	HT144	9.2
Skin	IGR1	9.5
Skin	IGR37	8.5
Skin	IGR39	8.7
Skin	IPC298	9.1
Skin	K029AX	9.1
Skin	LOXIMVI	9.9
Skin	MALME3M	8.6
Skin	MDAMB435S	9.8
Skin	MELHO	9.6
Skin	MELJUSO	9.4
Skin	MEWO	10.1
Skin	RPMI7951	9.7
Skin	RVH421	8.7
Skin	SH4	8.4
Skin	SKMEL1	9
Skin	SKMEL24	8.8
Skin	SKMEL28	9.3
Skin	SKMEL2	8.8
Skin	SKMEL30	9.2
Skin	SKMEL31	9.4
Skin	SKMEL3	8.5
Skin	SKMEL5	8.6
Skin	UACC257	9.7
Skin	UACC62	9.2
Skin	WM115	9.6
Skin	WM1799	9.6
Skin	WM2664	9.6
Skin	WM793	9.8
Skin	WM88	9.2
Skin	WM983B	9.6
Small intestine	HUTU80	10.1
Soft tissue	A204	8.8
Soft tissue	G401	10
Soft tissue	G402	9.5
Soft tissue	GCT	10
Soft tissue	HS729	9.3
Soft tissue	HT1080	9.3
Soft tissue	KYM1	11
Soft tissue	MESSA	8.2
Soft tissue	RD	9.8
Soft tissue	RH30	8.7
Soft tissue	RH41	9.8
Soft tissue	RKN	9.3
Soft tissue	S117	9.8
Soft tissue	SJRH30	10
Soft tissue	SKLMS1	9.2
Soft tissue	SKUT1	9.1
Soft tissue	TE125T	9
Soft tissue	TE159T	8.8
Soft tissue	TE441T	10
Soft tissue	TE617T	9.6
Stomach	2313287	9.8
Stomach	AGS	10.2
Stomach	AZ521	10.3
Stomach	ECC10	10.5
Stomach	ECC12	10.4
Stomach	FU97	8.9
Stomach	GCIY	10.2
Stomach	GSS	10.3
Stomach	GSU	9.4
Stomach	HGC27	9.6
Stomach	HS746T	9.9
Stomach	HUG1N	9.8
Stomach	IM95	9.6
Stomach	KATOIII	9.4
Stomach	KE39	9.4
Stomach	LMSU	9.5
Stomach	MKN1	9.6
Stomach	MKN45	9.4
Stomach	MKN74	10.6
Stomach	MKN7	8.9
Stomach	NCCSTCK140	9.4
Stomach	NCIN87	10
Stomach	NUGC2	8
Stomach	NUGC3	10.2
Stomach	NUGC4	9.7
Stomach	OCUM1	9.3
Stomach	RERFGC1B	10.1
Stomach	SH10TC	9.2
Stomach	SNU16	9.4
Stomach	SNU1	10.5
Stomach	SNU216	9.6
Stomach	SNU520	9.4
Stomach	SNU5	9
Stomach	SNU601	10.2
Stomach	SNU620	9
Stomach	SNU668	8.9
Stomach	SNU719	9
Stomach	TGBC11TKB	10
Thyroid	8305C	8.5
Thyroid	8505C	9.5
Thyroid	BCPAP	8.4
Thyroid	BHT101	8.7
Thyroid	CAL62	9.8
Thyroid	CGTHW1	8.8
Thyroid	FTC133	8.9
Thyroid	FTC238	10
Thyroid	ML1	9
Thyroid	SW579	9.1
Thyroid	TT2609C02	8.3
Thyroid	TT	10.5
Upper aerodigestive tract	BHY	9
Upper aerodigestive tract	BICR16	8
Upper aerodigestive tract	BICR18	9.5
Upper aerodigestive tract	BICR22	9.1
Upper aerodigestive tract	BICR31	9
Upper aerodigestive tract	BICR56	10.1
Upper aerodigestive tract	BICR6	9
Upper aerodigestive tract	CAL27	9.2
Upper aerodigestive tract	CAL33	9.4
Upper aerodigestive tract	DETROIT562	9.3
Upper aerodigestive tract	FADU	10.1
Upper aerodigestive tract	HS840T	9
Upper aerodigestive tract	HSC2	8.8
Upper aerodigestive tract	HSC3	8.8
Upper aerodigestive tract	HSC4	9.7
Upper aerodigestive tract	PECAPJ15	9.4
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	9.3
Upper aerodigestive tract	PECAPJ49	8.8
Upper aerodigestive tract	SCC15	8.7
Upper aerodigestive tract	SCC25	9.1
Upper aerodigestive tract	SCC4	9.7
Upper aerodigestive tract	SCC9	10.1
Upper aerodigestive tract	SNU1076	8.4
Upper aerodigestive tract	SNU1214	8.9
Upper aerodigestive tract	SNU46	9.1
Upper aerodigestive tract	SNU899	8.9
Upper aerodigestive tract	YD10B	9.3
Upper aerodigestive tract	YD38	9.6
Upper aerodigestive tract	YD8	9.1
Urinary tract	5637	8.8
Urinary tract	639V	10
Urinary tract	647V	9.1
Urinary tract	BC3C	9.3
Urinary tract	BFTC905	9.5
Urinary tract	CAL29	9.7
Urinary tract	HS172T	8.6
Urinary tract	HT1197	8.7
Urinary tract	HT1376	9.4
Urinary tract	J82	9.3
Urinary tract	JMSU1	9.7
Urinary tract	KMBC2	9.6
Urinary tract	KU1919	9.4
Urinary tract	RT11284	9.3
Urinary tract	RT112	9.2
Urinary tract	RT4	9.8
Urinary tract	SCABER	9.6
Urinary tract	SW1710	10
Urinary tract	SW780	9.8
Urinary tract	T24	8.9
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	7.3
Urinary tract	UMUC3	9.8
Urinary tract	VMCUB1	9.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	8.8
Adrenal gland	8.3
Appendix	13.1
Bone marrow	21.3
Breast	16.6
Cerebral cortex	10.3
Cervix, uterine	14.4
Colon	7.4
Duodenum	6.7
Endometrium	20.6
Epididymis	11.4
Esophagus	6.9
Fallopian tube	15.4
Gallbladder	11.5
Heart muscle	4.4
Kidney	7.4
Liver	2.7
Lung	13.3
Lymph node	14.7
Ovary	16.3
Pancreas	1.5
Parathyroid gland	21.9
Placenta	12.8
Prostate	15.3
Rectum	9.7
Salivary gland	4.1
Seminal vesicle	11.1
Skeletal muscle	1.8
Skin	11.9
Small intestine	8.6
Smooth muscle	11.9
Spleen	15.6
Stomach	8.6
Testis	13.5
Thyroid gland	14.8
Tonsil	9.9
Urinary bladder	8.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26004342	Overexpression	Breast Carcinoma	The present study demonstrates the mechanisms by which curcumin inhibits PhIP-induced cytotoxicity in normal breast epithelial cells (MCF-10A). PhIP suppressed the expression of the tumor suppressor P16 gene, whereas curcumin co-treatment increased its expression.
25628930	Overexpression	Prostate Carcinoma	Here, we describe our work in evaluating the molecular events associated with PhIP-mediated disruption of AR function in LNCaP human prostate cancer cells. In vitro assays show that PhIP increase AR protein expression in LNCaP cells and alters its responsiveness through PSA protein and mRNA expression.
22511720	Overexpression (copy number gain)	Melanoma	In addition, a high proportion of PHIP-overexpressing melanomas harbored increased PHIP copy number. PHIP-overexpressing melanomas include tumors with wild-type BRAF, neuroblastoma RAS viral (v-ras) oncogene homolog, and phosphatase and tensin homolog, demonstrating PHIP activation in triple-negative melanoma.

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.351	3.96e-13	41.6	50.2	8.2	Loss
BRCA	Breast invasive carcinoma	1075	0.343	5.87e-31	30	55.3	14.7	Neutral
CESC	Cervical and endocervical cancers	292	0.493	2.96e-19	24.3	65.4	10.3	Neutral
COAD	Colon adenocarcinoma	449	0.195	3.06e-05	12.2	70.8	16.9	Neutral
ESCA	Esophageal carcinoma	183	0.378	1.32e-07	25.1	56.8	18	Neutral
GBM	Glioblastoma multiforme	147	0.551	4.81e-13	29.3	67.3	3.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.204	3.11e-06	17.1	71.4	11.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.427	1.27e-24	22.7	75.6	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.183	0.00177	9.7	88.5	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	-0.07	0.368	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.279	1.29e-10	11.5	87.9	0.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.387	1.79e-14	29.1	55.8	15.1	Neutral
LUAD	Lung adenocarcinoma	512	0.338	3.48e-15	46.5	43.9	9.6	Loss
LUSC	Lung squamous cell carcinoma	498	0.459	2.84e-27	21.3	56	22.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.516	8.66e-22	38	37.3	24.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.414	9.72e-09	40.7	55.9	3.4	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.407	7.89e-08	9.9	84.6	5.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.31	2.23e-12	24.2	74.5	1.2	Neutral
READ	Rectum adenocarcinoma	164	0.128	0.104	14.6	64.6	20.7	Neutral
SARC	Sarcoma	255	0.446	7.19e-14	29	54.1	16.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.326	1.48e-10	45.2	43.1	11.7	Loss
STAD	Stomach adenocarcinoma	413	0.464	1.95e-23	19.4	65.6	15	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.306	0.000142	10.7	70.7	18.7	Neutral
THCA	Thyroid carcinoma	497	0.128	0.00435	1.2	98.4	0.4	Neutral
THYM	Thymoma	119	0.504	5.27e-09	16	84	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.218	3.37e-07	6.5	79.9	13.6	Neutral

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.276	8.4e-09	17	408	0.004	0.00103	NS/NA
BRCA	Breast invasive carcinoma	-0.281	3.85e-17	83	785	0.001	0.011	NS/NA
CESC	Cervical and endocervical cancers	-0.365	4.93e-11	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.129	0.0222	19	297	0.001	0.00425	NS/NA
ESCA	Esophageal carcinoma	-0.346	8.8e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.321	0.00929	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.316	6.79e-14	20	522	0.003	7.87e-16	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.173	0.00131	24	319	0.003	0.000593	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.208	0.000301	23	275	0.004	1.91e-16	NS/NA
LAML	Acute Myeloid Leukemia	-0.028	0.713	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.241	2.06e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.136	0.00559	41	373	0.003	4.04e-17	NS/NA
LUAD	Lung adenocarcinoma	-0.102	0.0256	21	456	0	0.576	NS/NA
LUSC	Lung squamous cell carcinoma	-0.058	0.259	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.8	0.0138	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.466	3.68e-11	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.209	0.00408	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.456	0	35	498	0.006	4.58e-29	NS/NA
READ	Rectum adenocarcinoma	-0.126	0.208	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.361	2.04e-09	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.339	5.06e-14	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.292	1.17e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.183	0.022	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.147	0.000507	50	509	-0.001	0.317	NS/NA
THYM	Thymoma	-0.215	0.0176	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.192	3.28e-05	34	431	0	0.0637	NS/NA

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	0	Not detected
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	1	Low
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	0	Not detected
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	1	Low
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.837	NS	24476821
BRCA	Breast invasive carcinoma	521	0.161	NS	23000897
COAD	Colon adenocarcinoma	149	0.874	NS	22810696
GBM	Glioblastoma multiforme	157	0.00167	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.63e-14	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00134	Significant	26536169
LGG	Brain Lower Grade Glioma	513	3e-06	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00276	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.03e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0054	Significant	21720365
PRAD	Prostate adenocarcinoma	333	1.7e-11	Significant	26544944
READ	Rectum adenocarcinoma	67	0.198	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.61	NS	26091043
STAD	Stomach adenocarcinoma	277	0.62	NS	25079317
THCA	Thyroid carcinoma	391	1.55e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.054	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.841	0.405	NS
BRCA	Breast invasive carcinoma	1079	1.133	0.59	NS
CESC	Cervical and endocervical cancers	291	1.073	0.844	NS
COAD	Colon adenocarcinoma	439	0.823	0.522	NS
ESCA	Esophageal carcinoma	184	1.461	0.208	NS
GBM	Glioblastoma multiforme	158	0.814	0.415	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.531	0.00167	Longer
KIRC	Kidney renal clear cell carcinoma	531	1.708	0.0111	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.648	0.257	NS
LAML	Acute Myeloid Leukemia	149	0.564	0.05	NS
LGG	Brain Lower Grade Glioma	511	1.726	0.033	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.175	0.508	NS
LUAD	Lung adenocarcinoma	502	0.832	0.394	NS
LUSC	Lung squamous cell carcinoma	494	0.982	0.925	NS
OV	Ovarian serous cystadenocarcinoma	303	0.781	0.234	NS
PAAD	Pancreatic adenocarcinoma	177	0.973	0.921	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.486	0.548	NS
PRAD	Prostate adenocarcinoma	497	1.521	0.682	NS
READ	Rectum adenocarcinoma	159	0.576	0.372	NS
SARC	Sarcoma	259	1.152	0.635	NS
SKCM	Skin Cutaneous Melanoma	459	0.698	0.069	NS
STAD	Stomach adenocarcinoma	388	0.989	0.963	NS
TGCT	Testicular Germ Cell Tumors	134	0.527	0.595	NS
THCA	Thyroid carcinoma	500	0.51	0.371	NS
THYM	Thymoma	119	0.32	0.298	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.562	0.115	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.134	0.007	Lower
BRCA	Breast invasive carcinoma	1071	-0.008	0.791	NS
CESC	Cervical and endocervical cancers	167	-0.016	0.835	NS
COAD	Colon adenocarcinoma	445	-0.009	0.856	NS
ESCA	Esophageal carcinoma	162	0.103	0.193	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.049	0.305	NS
KIRC	Kidney renal clear cell carcinoma	531	0.154	0.000364	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.02	0.752	NS
LIHC	Liver hepatocellular carcinoma	347	0.124	0.0204	Higher
LUAD	Lung adenocarcinoma	507	-0.109	0.0144	Lower
LUSC	Lung squamous cell carcinoma	497	-0.008	0.864	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.12	0.0376	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.034	0.653	NS
READ	Rectum adenocarcinoma	156	0.093	0.246	NS
SKCM	Skin Cutaneous Melanoma	410	-0.068	0.171	NS
STAD	Stomach adenocarcinoma	392	0.102	0.0438	Higher
TGCT	Testicular Germ Cell Tumors	81	-0.228	0.0406	Lower
THCA	Thyroid carcinoma	499	-0.037	0.414	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.08	0.073	NS

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.03	0.627	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.118	0.00826	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.061	0.162	NS
LGG	Brain Lower Grade Glioma	514	0.073	0.0997	NS
LIHC	Liver hepatocellular carcinoma	366	0.229	9.66e-06	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.063	0.277	NS
PAAD	Pancreatic adenocarcinoma	176	-0.134	0.0769	NS
STAD	Stomach adenocarcinoma	406	-0.016	0.744	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.199	3.73e-06	Higher

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PHIP.

Summary
Symbol	PHIP
Name	pleckstrin homology domain interacting protein
Aliases	ndrp; FLJ20705; DCAF14; DDB1 and CUL4 associated factor 14; IRS-1 PH domain-binding protein; PH-interacting ......
Location	6q14.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26004342	Breast Carcinoma	downstream	P16	Negative regulation	PhIP suppressed the expression of the tumor suppressor P16 gene, whereas curcumin co-treatment increased its expression.
25628930	Prostate Carcinoma	downstream	AR	Positive regulation	In vitro assays show that PhIP increase AR protein expression in LNCaP cells and alters its responsiveness through PSA protein and mRNA expression.
24518113	Melanoma	downstream	Akt	Positive regulation	PHIP has been found to be amplified in wild-type melanomas, resulting in Akt activation and aerobic glycolysis (Warburg effect), associated with ulceration.