CR2Cancer

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00808 Histone-like transcription factor (CBF/NF-Y) and archaeal histone

Function

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.

Classification

Class	Modification	Substrate	Product	PubMed
Histone chaperone	#	#	#	10880450

> Gene Ontology [ TOP ]
Biological Process	GO:0006260 DNA replication GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0071897 DNA biosynthetic process
Molecular Function	GO:0003887 DNA-directed DNA polymerase activity GO:0016779 nucleotidyltransferase activity GO:0034061 DNA polymerase activity GO:0046982 protein heterodimerization activity
Cellular Component	GO:0000109 nucleotide-excision repair complex GO:0000123 histone acetyltransferase complex GO:0005657 replication fork GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex GO:0008622 epsilon DNA polymerase complex GO:0030894 replisome GO:0031248 protein acetyltransferase complex GO:0032993 protein-DNA complex GO:0042575 DNA polymerase complex GO:0043596 nuclear replication fork GO:0043601 nuclear replisome GO:0044454 nuclear chromosome part GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex GO:1990391 DNA repair complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03030 DNA replication hsa03410 Base excision repair hsa03420 Nucleotide excision repair hsa00230 Purine metabolism hsa00240 Pyrimidine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-68962: Activation of the pre-replicative complex R-HSA-73884: Base Excision Repair R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-73886: Chromosome Maintenance R-HSA-73893: DNA Damage Bypass R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69306: DNA Replication R-HSA-69002: DNA Replication Pre-Initiation R-HSA-68952: DNA replication initiation R-HSA-5696400: Dual Incision in GG-NER R-HSA-6782135: Dual incision in TC-NER R-HSA-180786: Extension of Telomeres R-HSA-69206: G1/S Transition R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685942: HDR through Homologous Recombination (HRR) R-HSA-5693538: Homology Directed Repair R-HSA-68874: M/G1 Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-5696398: Nucleotide Excision Repair R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair R-HSA-110314: Recognition of DNA damage by PCNA-containing replication complex R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-69242: S Phase R-HSA-69239: Synthesis of DNA R-HSA-174417: Telomere C-strand (Lagging Strand) Synthesis R-HSA-174430: Telomere C-strand synthesis initiation R-HSA-157579: Telomere Maintenance R-HSA-5656169: Termination of translesion DNA synthesis R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03030 DNA replication
hsa03410 Base excision repair
hsa03420 Nucleotide excision repair
hsa00230 Purine metabolism
hsa00240 Pyrimidine metabolism
hsa01100 Metabolic pathways

Reactome

R-HSA-68962: Activation of the pre-replicative complex
R-HSA-73884: Base Excision Repair
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-73886: Chromosome Maintenance
R-HSA-73893: DNA Damage Bypass
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-69306: DNA Replication
R-HSA-69002: DNA Replication Pre-Initiation
R-HSA-68952: DNA replication initiation
R-HSA-5696400: Dual Incision in GG-NER
R-HSA-6782135: Dual incision in TC-NER
R-HSA-180786: Extension of Telomeres
R-HSA-69206: G1/S Transition
R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5685942: HDR through Homologous Recombination (HRR)
R-HSA-5693538: Homology Directed Repair
R-HSA-68874: M/G1 Transition
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-5651801: PCNA-Dependent Long Patch Base Excision Repair
R-HSA-110314: Recognition of DNA damage by PCNA-containing replication complex
R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-69242: S Phase
R-HSA-69239: Synthesis of DNA
R-HSA-174417: Telomere C-strand (Lagging Strand) Synthesis
R-HSA-174430: Telomere C-strand synthesis initiation
R-HSA-157579: Telomere Maintenance
R-HSA-5656169: Termination of translesion DNA synthesis
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4646217	c.119C>T	p.A40V	Substitution - Missense	Large_intestine
COSM4411409	c.43A>T	p.I15F	Substitution - Missense	Kidney
COSM3320186	c.321G>A	p.K107K	Substitution - coding silent	Breast
COSM1104232	c.158A>C	p.N53T	Substitution - Missense	Endometrium
COSM455184	c.160_162delAAC	p.N54delN	Deletion - In frame	Breast
COSM1104228	c.412_414delGAA	p.E138delE	Deletion - In frame	Endometrium
COSM4411409	c.43A>T	p.I15F	Substitution - Missense	Kidney
COSM3320185	c.340delA	p.T114fs*32	Deletion - Frameshift	Stomach
COSM3432787	c.54C>A	p.I18I	Substitution - coding silent	Large_intestine
COSM4646217	c.119C>T	p.A40V	Substitution - Missense	Large_intestine
COSM3320191	c.191T>C	p.L64P	Substitution - Missense	Large_intestine
COSM4411409	c.43A>T	p.I15F	Substitution - Missense	Kidney
COSM1176425	c.347C>T	p.S116L	Substitution - Missense	Endometrium
COSM4411409	c.43A>T	p.I15F	Substitution - Missense	Kidney
COSM1104230	c.347C>A	p.S116*	Substitution - Nonsense	Endometrium
COSM284132	c.181C>T	p.R61W	Substitution - Missense	Large_intestine
COSM4411409	c.43A>T	p.I15F	Substitution - Missense	Kidney
COSM284132	c.181C>T	p.R61W	Substitution - Missense	Large_intestine
COSM4656465	c.45C>T	p.I15I	Substitution - coding silent	Large_intestine
COSM5016971	c.428A>T	p.E143V	Substitution - Missense	Kidney
COSM4938712	c.145A>G	p.T49A	Substitution - Missense	Liver
COSM6013601	c.268G>C	p.E90Q	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
25529843	Mutation	Colorectal Adenocarcinoma ; Colorectal Carcinoma	Therefore, targeted sequencing of the polymerase genes POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3 and POLE4 was performed in 266 unrelated patients with polyposis or fulfilled Amsterdam criteria. The POLE mutation c.1270C>G;p.Leu424Val was detected in four unrelated patients.; The mutation was present in 1.5% (4/266) of all patients, 4% (3/77) of all familial cases and 7% (2/30) of familial polyposis cases.

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9NRF9	83	T	Phosphothreonine	-	No	None detected
Q9NRF9	122	S	Phosphoserine	-	No	None detected

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.879	6.217	0.379	0.0203	NS
BRCA	Breast invasive carcinoma	112	1100	5.939	6.398	0.473	6.48e-25	NS
CESC	Cervical and endocervical cancers	3	306	5.935	6.891	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.918	6.58	0.613	4.11e-12	Over
ESCA	Esophageal carcinoma	11	185	5.38	6.256	0.84	4.98e-05	Over
GBM	Glioblastoma multiforme	5	166	5.746	6.7	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.119	6.61	0.445	1.65e-07	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.516	5.9	0.318	5.26e-11	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.353	5.81	0.429	3.92e-09	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.01	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.094	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.057	5.229	0.194	0.00899	NS
LUAD	Lung adenocarcinoma	59	517	5.706	6.056	0.372	1.02e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	5.627	6.653	1.036	5.08e-27	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.65	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.534	5.725	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.985	5.396	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.775	5.906	0.111	0.0467	NS
READ	Rectum adenocarcinoma	10	167	6.085	6.56	0.35	0.0929	NS
SARC	Sarcoma	2	263	5.44	6.298	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.213	6.074	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.746	6.187	0.402	9.67e-06	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.229	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.57	5.718	0.137	0.00108	NS
THYM	Thymoma	2	120	6.204	6.647	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.804	6.12	0.33	0.00115	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.8
Autonomic ganglia	CHP212	10.7
Autonomic ganglia	IMR32	10.7
Autonomic ganglia	KELLY	10.2
Autonomic ganglia	KPNRTBM1	10.5
Autonomic ganglia	KPNSI9S	10.1
Autonomic ganglia	KPNYN	10.7
Autonomic ganglia	MHHNB11	10.5
Autonomic ganglia	NB1	11
Autonomic ganglia	NH6	10.5
Autonomic ganglia	SHSY5Y	9.7
Autonomic ganglia	SIMA	10.5
Autonomic ganglia	SKNAS	10.1
Autonomic ganglia	SKNBE2	10.7
Autonomic ganglia	SKNDZ	10.9
Autonomic ganglia	SKNFI	10.7
Autonomic ganglia	SKNSH	10.3
Biliary tract	HUCCT1	10.4
Biliary tract	HUH28	9.6
Biliary tract	SNU1079	9.1
Biliary tract	SNU1196	11.7
Biliary tract	SNU245	10.6
Biliary tract	SNU308	10.9
Biliary tract	SNU478	10.6
Bone	143B	10.9
Bone	A673	10.6
Bone	CADOES1	9.5
Bone	CAL78	10.6
Bone	G292CLONEA141B1	10.1
Bone	HOS	11.2
Bone	HS706T	10
Bone	HS737T	9.2
Bone	HS819T	8.7
Bone	HS821T	9.8
Bone	HS822T	8.9
Bone	HS863T	9.6
Bone	HS870T	9.6
Bone	HS888T	9.9
Bone	MG63	10.4
Bone	MHHES1	10.6
Bone	OUMS27	9.8
Bone	RDES	10.1
Bone	SJSA1	9.8
Bone	SKES1	11.2
Bone	SKNMC	10.8
Bone	SW1353	9.6
Bone	T173	9.4
Bone	TC71	11.4
Bone	U2OS	10.7
Breast	AU565	10
Breast	BT20	10.7
Breast	BT474	9.8
Breast	BT483	9.7
Breast	BT549	10.7
Breast	CAL120	10.3
Breast	CAL148	10.9
Breast	CAL51	10.4
Breast	CAL851	10
Breast	CAMA1	10.3
Breast	DU4475	9.8
Breast	EFM192A	10.8
Breast	EFM19	10.8
Breast	EVSAT	11.2
Breast	HCC1143	10.4
Breast	HCC1187	10
Breast	HCC1395	9.9
Breast	HCC1419	10
Breast	HCC1428	10.8
Breast	HCC1500	10.9
Breast	HCC1569	9.6
Breast	HCC1599	11.3
Breast	HCC1806	9.9
Breast	HCC1937	10.7
Breast	HCC1954	10.5
Breast	HCC202	10.1
Breast	HCC2157	10.5
Breast	HCC2218	10.4
Breast	HCC38	10.2
Breast	HCC70	9.9
Breast	HDQP1	9.3
Breast	HMC18	11
Breast	HS274T	9.7
Breast	HS281T	9.8
Breast	HS343T	10.2
Breast	HS578T	9.3
Breast	HS606T	9.3
Breast	HS739T	9.2
Breast	HS742T	9.4
Breast	JIMT1	10.5
Breast	KPL1	11.1
Breast	MCF7	10.8
Breast	MDAMB134VI	10.1
Breast	MDAMB157	9.8
Breast	MDAMB175VII	9.3
Breast	MDAMB231	10.7
Breast	MDAMB361	10.4
Breast	MDAMB415	9.7
Breast	MDAMB436	10.5
Breast	MDAMB453	9.8
Breast	MDAMB468	10.3
Breast	SKBR3	10.2
Breast	T47D	10.7
Breast	UACC812	8.8
Breast	UACC893	10.4
Breast	YMB1	9.7
Breast	ZR751	10
Breast	ZR7530	9.9
Central nervous system	1321N1	10.7
Central nervous system	42MGBA	10.5
Central nervous system	8MGBA	10.4
Central nervous system	A172	10.3
Central nervous system	AM38	10.8
Central nervous system	BECKER	10.8
Central nervous system	CAS1	9.9
Central nervous system	CCFSTTG1	10.2
Central nervous system	D283MED	10.8
Central nervous system	D341MED	9.2
Central nervous system	DAOY	11.6
Central nervous system	DBTRG05MG	10.1
Central nervous system	DKMG	9.4
Central nervous system	GAMG	10.7
Central nervous system	GB1	11.6
Central nervous system	GI1	10.1
Central nervous system	GMS10	10.5
Central nervous system	GOS3	10.2
Central nervous system	H4	10.1
Central nervous system	HS683	10.1
Central nervous system	KALS1	10.6
Central nervous system	KG1C	10.2
Central nervous system	KNS42	11.4
Central nervous system	KNS60	10.2
Central nervous system	KNS81	10.4
Central nervous system	KS1	10.1
Central nervous system	LN18	10.2
Central nervous system	LN229	10.6
Central nervous system	M059K	10.3
Central nervous system	MOGGCCM	10.7
Central nervous system	MOGGUVW	10.8
Central nervous system	NMCG1	10.1
Central nervous system	ONS76	9.8
Central nervous system	SF126	10.6
Central nervous system	SF295	10.7
Central nervous system	SNB19	10.9
Central nervous system	SNU1105	10.7
Central nervous system	SNU201	10.4
Central nervous system	SNU466	10.2
Central nervous system	SNU489	10.4
Central nervous system	SNU626	11
Central nervous system	SNU738	10.6
Central nervous system	SW1088	10.4
Central nervous system	SW1783	10.5
Central nervous system	T98G	10.2
Central nervous system	TM31	10.4
Central nervous system	U118MG	10.7
Central nervous system	U138MG	10.1
Central nervous system	U251MG	10.3
Central nervous system	U87MG	10.1
Central nervous system	YH13	10
Central nervous system	YKG1	10.4
Endometrium	AN3CA	11
Endometrium	COLO684	10
Endometrium	EFE184	10
Endometrium	EN	10.9
Endometrium	ESS1	10.8
Endometrium	HEC108	9.3
Endometrium	HEC151	10.9
Endometrium	HEC1A	10.6
Endometrium	HEC1B	10.4
Endometrium	HEC251	10.3
Endometrium	HEC265	10.4
Endometrium	HEC50B	10.1
Endometrium	HEC59	11
Endometrium	HEC6	10.9
Endometrium	ISHIKAWAHERAKLIO02ER	10.8
Endometrium	JHUEM1	9.4
Endometrium	JHUEM2	10.6
Endometrium	JHUEM3	10
Endometrium	KLE	10.6
Endometrium	MFE280	10.3
Endometrium	MFE296	11
Endometrium	MFE319	10.4
Endometrium	RL952	10.3
Endometrium	SNGM	9.8
Endometrium	SNU1077	9.4
Endometrium	SNU685	9.8
Endometrium	TEN	9.6
Haematopoietic and lymphoid	697	11.2
Haematopoietic and lymphoid	A3KAW	11.1
Haematopoietic and lymphoid	A4FUK	11.3
Haematopoietic and lymphoid	ALLSIL	11.7
Haematopoietic and lymphoid	AML193	11.5
Haematopoietic and lymphoid	AMO1	11.2
Haematopoietic and lymphoid	BCP1	11
Haematopoietic and lymphoid	BDCM	10.3
Haematopoietic and lymphoid	BL41	12
Haematopoietic and lymphoid	BL70	11.5
Haematopoietic and lymphoid	BV173	9.8
Haematopoietic and lymphoid	CA46	11.2
Haematopoietic and lymphoid	CI1	11.2
Haematopoietic and lymphoid	CMK115	11.2
Haematopoietic and lymphoid	CMK86	10.9
Haematopoietic and lymphoid	CMK	10.7
Haematopoietic and lymphoid	CMLT1	11.1
Haematopoietic and lymphoid	COLO775	10.8
Haematopoietic and lymphoid	DAUDI	10.7
Haematopoietic and lymphoid	DB	10.9
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	10.9
Haematopoietic and lymphoid	DOHH2	11.3
Haematopoietic and lymphoid	EB1	10.4
Haematopoietic and lymphoid	EB2	10.4
Haematopoietic and lymphoid	EHEB	9.1
Haematopoietic and lymphoid	EJM	11.6
Haematopoietic and lymphoid	EM2	10.7
Haematopoietic and lymphoid	EOL1	10.7
Haematopoietic and lymphoid	F36P	11
Haematopoietic and lymphoid	GA10	11.6
Haematopoietic and lymphoid	GDM1	10.5
Haematopoietic and lymphoid	GRANTA519	10.5
Haematopoietic and lymphoid	HDLM2	9.7
Haematopoietic and lymphoid	HDMYZ	9.7
Haematopoietic and lymphoid	HEL9217	10.6
Haematopoietic and lymphoid	HEL	10.4
Haematopoietic and lymphoid	HH	10.5
Haematopoietic and lymphoid	HL60	11.8
Haematopoietic and lymphoid	HPBALL	11.2
Haematopoietic and lymphoid	HS604T	8.5
Haematopoietic and lymphoid	HS611T	10.2
Haematopoietic and lymphoid	HS616T	9.5
Haematopoietic and lymphoid	HS751T	10
Haematopoietic and lymphoid	HT	11.2
Haematopoietic and lymphoid	HTK	10.6
Haematopoietic and lymphoid	HUNS1	10.6
Haematopoietic and lymphoid	HUT102	9.8
Haematopoietic and lymphoid	HUT78	11.2
Haematopoietic and lymphoid	JEKO1	12.5
Haematopoietic and lymphoid	JK1	10.5
Haematopoietic and lymphoid	JM1	11.3
Haematopoietic and lymphoid	JURKAT	11.1
Haematopoietic and lymphoid	JURLMK1	9.7
Haematopoietic and lymphoid	JVM2	9
Haematopoietic and lymphoid	JVM3	9.6
Haematopoietic and lymphoid	K562	10.4
Haematopoietic and lymphoid	KARPAS299	10.1
Haematopoietic and lymphoid	KARPAS422	10.9
Haematopoietic and lymphoid	KARPAS620	10.6
Haematopoietic and lymphoid	KASUMI1	10.7
Haematopoietic and lymphoid	KASUMI2	11.2
Haematopoietic and lymphoid	KASUMI6	11.4
Haematopoietic and lymphoid	KCL22	11
Haematopoietic and lymphoid	KE37	11
Haematopoietic and lymphoid	KE97	10.9
Haematopoietic and lymphoid	KG1	11.2
Haematopoietic and lymphoid	KHM1B	11.1
Haematopoietic and lymphoid	KIJK	11.6
Haematopoietic and lymphoid	KMH2	10.3
Haematopoietic and lymphoid	KMM1	10.8
Haematopoietic and lymphoid	KMS11	11.6
Haematopoietic and lymphoid	KMS12BM	11.7
Haematopoietic and lymphoid	KMS18	10.6
Haematopoietic and lymphoid	KMS20	11.3
Haematopoietic and lymphoid	KMS21BM	10.3
Haematopoietic and lymphoid	KMS26	11.5
Haematopoietic and lymphoid	KMS27	10.9
Haematopoietic and lymphoid	KMS28BM	11.5
Haematopoietic and lymphoid	KMS34	11.6
Haematopoietic and lymphoid	KO52	11.1
Haematopoietic and lymphoid	KOPN8	11.5
Haematopoietic and lymphoid	KU812	10.7
Haematopoietic and lymphoid	KYO1	10
Haematopoietic and lymphoid	L1236	10.8
Haematopoietic and lymphoid	L363	11.2
Haematopoietic and lymphoid	L428	10
Haematopoietic and lymphoid	L540	9.6
Haematopoietic and lymphoid	LAMA84	9.3
Haematopoietic and lymphoid	LOUCY	11
Haematopoietic and lymphoid	LP1	10.6
Haematopoietic and lymphoid	M07E	11
Haematopoietic and lymphoid	MC116	11.3
Haematopoietic and lymphoid	ME1	10.2
Haematopoietic and lymphoid	MEC1	11.4
Haematopoietic and lymphoid	MEC2	11.4
Haematopoietic and lymphoid	MEG01	10.9
Haematopoietic and lymphoid	MHHCALL2	11.6
Haematopoietic and lymphoid	MHHCALL3	11.9
Haematopoietic and lymphoid	MHHCALL4	11.4
Haematopoietic and lymphoid	MINO	11.2
Haematopoietic and lymphoid	MJ	10
Haematopoietic and lymphoid	MM1S	11.8
Haematopoietic and lymphoid	MOLM13	11.1
Haematopoietic and lymphoid	MOLM16	11.1
Haematopoietic and lymphoid	MOLM6	10.6
Haematopoietic and lymphoid	MOLP2	10.6
Haematopoietic and lymphoid	MOLP8	10.6
Haematopoietic and lymphoid	MOLT13	11.3
Haematopoietic and lymphoid	MOLT16	10.3
Haematopoietic and lymphoid	MOLT4	11.3
Haematopoietic and lymphoid	MONOMAC1	11.2
Haematopoietic and lymphoid	MONOMAC6	11.3
Haematopoietic and lymphoid	MOTN1	10.4
Haematopoietic and lymphoid	MUTZ5	11.4
Haematopoietic and lymphoid	MV411	11
Haematopoietic and lymphoid	NALM19	11.9
Haematopoietic and lymphoid	NALM1	11.2
Haematopoietic and lymphoid	NALM6	11.2
Haematopoietic and lymphoid	NAMALWA	11.5
Haematopoietic and lymphoid	NB4	11.3
Haematopoietic and lymphoid	NCIH929	11.3
Haematopoietic and lymphoid	NCO2	10.5
Haematopoietic and lymphoid	NOMO1	11.6
Haematopoietic and lymphoid	NUDHL1	10.7
Haematopoietic and lymphoid	NUDUL1	11.3
Haematopoietic and lymphoid	OCIAML2	10.9
Haematopoietic and lymphoid	OCIAML3	10.7
Haematopoietic and lymphoid	OCIAML5	11.1
Haematopoietic and lymphoid	OCILY10	11.1
Haematopoietic and lymphoid	OCILY19	11.5
Haematopoietic and lymphoid	OCILY3	10.8
Haematopoietic and lymphoid	OCIM1	10.6
Haematopoietic and lymphoid	OPM2	11.2
Haematopoietic and lymphoid	P12ICHIKAWA	10.9
Haematopoietic and lymphoid	P31FUJ	11.1
Haematopoietic and lymphoid	P3HR1	11.3
Haematopoietic and lymphoid	PCM6	10.5
Haematopoietic and lymphoid	PEER	10.5
Haematopoietic and lymphoid	PF382	10.7
Haematopoietic and lymphoid	PFEIFFER	11
Haematopoietic and lymphoid	PL21	11
Haematopoietic and lymphoid	RAJI	11.2
Haematopoietic and lymphoid	RCHACV	11.8
Haematopoietic and lymphoid	REC1	10.9
Haematopoietic and lymphoid	REH	11.6
Haematopoietic and lymphoid	RI1	11.5
Haematopoietic and lymphoid	RL	11.6
Haematopoietic and lymphoid	RPMI8226	10.9
Haematopoietic and lymphoid	RPMI8402	11.2
Haematopoietic and lymphoid	RS411	11.1
Haematopoietic and lymphoid	SEM	11.4
Haematopoietic and lymphoid	SET2	9.7
Haematopoietic and lymphoid	SIGM5	11.1
Haematopoietic and lymphoid	SKM1	10.5
Haematopoietic and lymphoid	SKMM2	11.1
Haematopoietic and lymphoid	SR786	9.9
Haematopoietic and lymphoid	ST486	11.8
Haematopoietic and lymphoid	SUDHL10	11.2
Haematopoietic and lymphoid	SUDHL1	10.7
Haematopoietic and lymphoid	SUDHL4	11.2
Haematopoietic and lymphoid	SUDHL5	11.5
Haematopoietic and lymphoid	SUDHL6	11.2
Haematopoietic and lymphoid	SUDHL8	11.9
Haematopoietic and lymphoid	SUPB15	11
Haematopoietic and lymphoid	SUPHD1	10.4
Haematopoietic and lymphoid	SUPM2	10.1
Haematopoietic and lymphoid	SUPT11	11.5
Haematopoietic and lymphoid	SUPT1	11.2
Haematopoietic and lymphoid	TALL1	10.6
Haematopoietic and lymphoid	TF1	11.1
Haematopoietic and lymphoid	THP1	10.8
Haematopoietic and lymphoid	TO175T	9.5
Haematopoietic and lymphoid	TOLEDO	11.1
Haematopoietic and lymphoid	U266B1	11.8
Haematopoietic and lymphoid	U937	10.5
Haematopoietic and lymphoid	UT7	10.2
Haematopoietic and lymphoid	WSUDLCL2	10.7
Kidney	769P	10.2
Kidney	786O	10.8
Kidney	A498	10.1
Kidney	A704	9.1
Kidney	ACHN	10
Kidney	BFTC909	10.3
Kidney	CAKI1	9.6
Kidney	CAKI2	10.2
Kidney	CAL54	9.8
Kidney	KMRC1	9.7
Kidney	KMRC20	10.5
Kidney	KMRC2	10.2
Kidney	KMRC3	9.3
Kidney	OSRC2	9.5
Kidney	RCC10RGB	9.6
Kidney	SNU1272	10.1
Kidney	SNU349	9.2
Kidney	TUHR10TKB	10.6
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	9.9
Kidney	VMRCRCW	10.6
Kidney	VMRCRCZ	9.2
Large intestine	C2BBE1	10.1
Large intestine	CCK81	10.6
Large intestine	CL11	10.2
Large intestine	CL14	10.4
Large intestine	CL34	10.2
Large intestine	CL40	10.3
Large intestine	COLO205	11.3
Large intestine	COLO320	11.4
Large intestine	COLO678	10
Large intestine	CW2	11.3
Large intestine	DLD1	10.4
Large intestine	GP2D	10.4
Large intestine	HCC56	10.5
Large intestine	HCT116	11.1
Large intestine	HCT15	11
Large intestine	HS675T	9
Large intestine	HS698T	9.9
Large intestine	HT115	10.6
Large intestine	HT29	11
Large intestine	HT55	10.3
Large intestine	KM12	10.6
Large intestine	LOVO	10.4
Large intestine	LS1034	10.2
Large intestine	LS123	10.7
Large intestine	LS180	10.6
Large intestine	LS411N	10.7
Large intestine	LS513	10.7
Large intestine	MDST8	10.6
Large intestine	NCIH508	9.4
Large intestine	NCIH716	10.3
Large intestine	NCIH747	10.7
Large intestine	OUMS23	9.4
Large intestine	RCM1	9.7
Large intestine	RKO	11.3
Large intestine	SKCO1	9.2
Large intestine	SNU1040	10.3
Large intestine	SNU1197	10.4
Large intestine	SNU175	10.3
Large intestine	SNU283	10.9
Large intestine	SNU407	10.7
Large intestine	SNU503	10.3
Large intestine	SNU61	11.2
Large intestine	SNU81	10
Large intestine	SNUC1	10.1
Large intestine	SNUC2A	10
Large intestine	SNUC4	11.1
Large intestine	SNUC5	10.2
Large intestine	SW1116	9.4
Large intestine	SW1417	10.6
Large intestine	SW1463	10.4
Large intestine	SW403	10.4
Large intestine	SW480	10.6
Large intestine	SW48	10.5
Large intestine	SW620	10.6
Large intestine	SW837	10.2
Large intestine	SW948	10.6
Large intestine	T84	10.1
Liver	ALEXANDERCELLS	10.6
Liver	C3A	9.9
Liver	HEP3B217	11
Liver	HEPG2	9.9
Liver	HLE	10.2
Liver	HLF	10
Liver	HUH1	10.5
Liver	HUH6	9.9
Liver	HUH7	10.5
Liver	JHH1	9.6
Liver	JHH2	9.7
Liver	JHH4	10.1
Liver	JHH5	10.6
Liver	JHH6	10.7
Liver	JHH7	10.1
Liver	LI7	10.8
Liver	PLCPRF5	9.8
Liver	SKHEP1	9.6
Liver	SNU182	10.9
Liver	SNU387	11.1
Liver	SNU398	10.5
Liver	SNU423	10.5
Liver	SNU449	10.1
Liver	SNU475	10
Liver	SNU761	8.6
Liver	SNU878	10.4
Liver	SNU886	10.5
Lung	A549	10.6
Lung	ABC1	10.6
Lung	BEN	9.4
Lung	CAL12T	11.1
Lung	CALU1	10.6
Lung	CALU3	9.4
Lung	CALU6	10.3
Lung	CHAGOK1	10.5
Lung	COLO668	11.1
Lung	COLO699	10.9
Lung	CORL105	10.4
Lung	CORL23	10.1
Lung	CORL24	8.9
Lung	CORL279	9.4
Lung	CORL311	9.5
Lung	CORL47	10.8
Lung	CORL51	9.9
Lung	CORL88	10.8
Lung	CORL95	10.3
Lung	CPCN	10.2
Lung	DMS114	9.8
Lung	DMS153	10.4
Lung	DMS273	10.8
Lung	DMS454	10.3
Lung	DMS53	9.7
Lung	DMS79	10.5
Lung	DV90	10.5
Lung	EBC1	11.1
Lung	EPLC272H	10.6
Lung	HARA	11.1
Lung	HCC1171	10.2
Lung	HCC1195	10.5
Lung	HCC15	10.6
Lung	HCC2279	10.4
Lung	HCC2935	10.8
Lung	HCC33	10.5
Lung	HCC366	10.1
Lung	HCC4006	10.8
Lung	HCC44	11
Lung	HCC78	9.8
Lung	HCC827	11.2
Lung	HCC95	10.9
Lung	HLC1	11.3
Lung	HLFA	9.5
Lung	HS229T	10.3
Lung	HS618T	10.2
Lung	IALM	9.5
Lung	KNS62	10.2
Lung	LC1F	10.9
Lung	LC1SQSF	11.1
Lung	LCLC103H	10.3
Lung	LCLC97TM1	10.5
Lung	LK2	11.1
Lung	LOUNH91	9.7
Lung	LU65	10.7
Lung	LU99	10.9
Lung	LUDLU1	11.4
Lung	LXF289	10.1
Lung	MORCPR	10.6
Lung	NCIH1048	10.8
Lung	NCIH1092	10.2
Lung	NCIH1105	10
Lung	NCIH1155	10.9
Lung	NCIH1184	10.6
Lung	NCIH1299	11.4
Lung	NCIH1339	10.2
Lung	NCIH1341	10.5
Lung	NCIH1355	10.4
Lung	NCIH1373	11.3
Lung	NCIH1385	9.8
Lung	NCIH1395	9.3
Lung	NCIH1435	10.9
Lung	NCIH1436	9.7
Lung	NCIH1437	10.1
Lung	NCIH146	10
Lung	NCIH1563	9.5
Lung	NCIH1568	10.3
Lung	NCIH1573	9.2
Lung	NCIH1581	10
Lung	NCIH1618	10.2
Lung	NCIH1623	9.8
Lung	NCIH1648	10.1
Lung	NCIH1650	10
Lung	NCIH1651	9.7
Lung	NCIH1666	10.3
Lung	NCIH1693	10.2
Lung	NCIH1694	10.8
Lung	NCIH1703	10.7
Lung	NCIH1734	11
Lung	NCIH1755	10.3
Lung	NCIH1781	10.1
Lung	NCIH1792	10.4
Lung	NCIH1793	10.6
Lung	NCIH1836	9.6
Lung	NCIH1838	9.4
Lung	NCIH1869	10.2
Lung	NCIH1876	10.7
Lung	NCIH1915	11.3
Lung	NCIH1930	10.2
Lung	NCIH1944	10.8
Lung	NCIH1963	10.8
Lung	NCIH196	10
Lung	NCIH1975	10.3
Lung	NCIH2009	10.8
Lung	NCIH2023	10.7
Lung	NCIH2029	10.2
Lung	NCIH2030	9.4
Lung	NCIH2066	9.4
Lung	NCIH2081	9.8
Lung	NCIH2085	9.7
Lung	NCIH2087	9.9
Lung	NCIH209	10.8
Lung	NCIH2106	10.6
Lung	NCIH2110	10.2
Lung	NCIH211	11.1
Lung	NCIH2122	9.9
Lung	NCIH2126	9.8
Lung	NCIH2141	11
Lung	NCIH2170	10.5
Lung	NCIH2171	11.2
Lung	NCIH2172	10.8
Lung	NCIH2196	10.5
Lung	NCIH2227	9.2
Lung	NCIH2228	10.8
Lung	NCIH226	10.7
Lung	NCIH2286	10.6
Lung	NCIH2291	10.8
Lung	NCIH2342	10.8
Lung	NCIH2347	10
Lung	NCIH23	10.4
Lung	NCIH2405	9.8
Lung	NCIH2444	9.2
Lung	NCIH292	10.4
Lung	NCIH322	10.3
Lung	NCIH3255	10.2
Lung	NCIH358	11.1
Lung	NCIH441	9.4
Lung	NCIH446	9.4
Lung	NCIH460	11.5
Lung	NCIH510	10.6
Lung	NCIH520	10.9
Lung	NCIH522	10.5
Lung	NCIH524	11.5
Lung	NCIH526	10.1
Lung	NCIH596	9.8
Lung	NCIH647	10.3
Lung	NCIH650	9.1
Lung	NCIH661	10.1
Lung	NCIH69	10.6
Lung	NCIH727	10.1
Lung	NCIH810	10.9
Lung	NCIH82	11
Lung	NCIH838	10.6
Lung	NCIH841	9.8
Lung	NCIH854	9.7
Lung	NCIH889	10.9
Lung	PC14	10.6
Lung	RERFLCAD1	10.3
Lung	RERFLCAD2	9.6
Lung	RERFLCAI	10.8
Lung	RERFLCKJ	9.7
Lung	RERFLCMS	10.6
Lung	RERFLCSQ1	10.2
Lung	SBC5	9.8
Lung	SCLC21H	10.4
Lung	SHP77	10.7
Lung	SKLU1	10.4
Lung	SKMES1	9.5
Lung	SQ1	10.1
Lung	SW1271	10.7
Lung	SW1573	10
Lung	SW900	10.1
Lung	VMRCLCD	11.2
Lung	VMRCLCP	10.3
Oesophagus	COLO680N	10.2
Oesophagus	ECGI10	10.5
Oesophagus	KYSE140	10.8
Oesophagus	KYSE150	10.6
Oesophagus	KYSE180	11.2
Oesophagus	KYSE270	10.1
Oesophagus	KYSE30	10
Oesophagus	KYSE410	10.6
Oesophagus	KYSE450	11.5
Oesophagus	KYSE510	11.1
Oesophagus	KYSE520	10.1
Oesophagus	KYSE70	10.4
Oesophagus	OE19	11
Oesophagus	OE33	9.4
Oesophagus	TE10	10.4
Oesophagus	TE11	11
Oesophagus	TE14	10.9
Oesophagus	TE15	10.9
Oesophagus	TE1	10.7
Oesophagus	TE4	11.3
Oesophagus	TE5	10.1
Oesophagus	TE6	10.1
Oesophagus	TE8	11.1
Oesophagus	TE9	10.4
Oesophagus	TT	10.2
Ovary	59M	9.9
Ovary	A2780	10.6
Ovary	CAOV3	10.8
Ovary	CAOV4	9.2
Ovary	COLO704	10.4
Ovary	COV318	10.1
Ovary	COV362	11
Ovary	COV434	10.4
Ovary	COV504	10.6
Ovary	COV644	9.7
Ovary	EFO21	9.8
Ovary	EFO27	9.6
Ovary	ES2	10.4
Ovary	FUOV1	9.9
Ovary	HEYA8	10.9
Ovary	HS571T	9.1
Ovary	IGROV1	10.3
Ovary	JHOC5	9.9
Ovary	JHOM1	9.6
Ovary	JHOM2B	10.5
Ovary	JHOS2	10.5
Ovary	JHOS4	10.2
Ovary	KURAMOCHI	9.5
Ovary	MCAS	10.7
Ovary	NIHOVCAR3	9.9
Ovary	OAW28	10.7
Ovary	OAW42	10
Ovary	OC314	10.4
Ovary	OC316	10.8
Ovary	ONCODG1	9.8
Ovary	OV56	10.1
Ovary	OV7	10.6
Ovary	OV90	9.9
Ovary	OVCAR4	9.9
Ovary	OVCAR8	10.5
Ovary	OVISE	10
Ovary	OVK18	10.8
Ovary	OVKATE	11.3
Ovary	OVMANA	7.8
Ovary	OVSAHO	9.8
Ovary	OVTOKO	9.5
Ovary	RMGI	10.4
Ovary	RMUGS	11.2
Ovary	SKOV3	10.2
Ovary	SNU119	9.3
Ovary	SNU840	10
Ovary	SNU8	9.7
Ovary	TOV112D	10.3
Ovary	TOV21G	9.1
Ovary	TYKNU	10.4
Pancreas	ASPC1	8.8
Pancreas	BXPC3	11
Pancreas	CAPAN1	9.9
Pancreas	CAPAN2	9.9
Pancreas	CFPAC1	8.8
Pancreas	DANG	11.1
Pancreas	HPAC	9.6
Pancreas	HPAFII	9.7
Pancreas	HS766T	10.4
Pancreas	HUPT3	10.6
Pancreas	HUPT4	10.7
Pancreas	KCIMOH1	9.9
Pancreas	KLM1	11.6
Pancreas	KP2	10.2
Pancreas	KP3	10
Pancreas	KP4	10.7
Pancreas	L33	10.4
Pancreas	MIAPACA2	10.7
Pancreas	PANC0203	10.2
Pancreas	PANC0213	10
Pancreas	PANC0327	10.6
Pancreas	PANC0403	9.5
Pancreas	PANC0504	9.9
Pancreas	PANC0813	11.1
Pancreas	PANC1005	10.7
Pancreas	PANC1	10.3
Pancreas	PATU8902	10.9
Pancreas	PATU8988S	10.4
Pancreas	PATU8988T	11
Pancreas	PK1	11.1
Pancreas	PK45H	10.8
Pancreas	PK59	10
Pancreas	PL45	10.7
Pancreas	PSN1	10.8
Pancreas	QGP1	10.1
Pancreas	SNU213	10.1
Pancreas	SNU324	10.6
Pancreas	SNU410	10.5
Pancreas	SU8686	8.6
Pancreas	SUIT2	10.8
Pancreas	SW1990	10.6
Pancreas	T3M4	10.6
Pancreas	TCCPAN2	10.1
Pancreas	YAPC	10
Pleura	ACCMESO1	11
Pleura	DM3	9.6
Pleura	ISTMES1	10.4
Pleura	ISTMES2	10.9
Pleura	JL1	10.6
Pleura	MPP89	10.5
Pleura	MSTO211H	10.8
Pleura	NCIH2052	10.2
Pleura	NCIH2452	10.6
Pleura	NCIH28	10.8
Prostate	22RV1	10.9
Prostate	DU145	10.9
Prostate	LNCAPCLONEFGC	10.1
Prostate	MDAPCA2B	10.4
Prostate	NCIH660	9.9
Prostate	PC3	9.9
Prostate	VCAP	11
Salivary gland	A253	11.2
Salivary gland	YD15	11.1
Skin	A101D	10
Skin	A2058	10.5
Skin	A375	10.5
Skin	C32	10.5
Skin	CHL1	10.3
Skin	CJM	10.7
Skin	COLO679	10.3
Skin	COLO741	10.1
Skin	COLO783	9.6
Skin	COLO792	11.1
Skin	COLO800	9.9
Skin	COLO818	10.3
Skin	COLO829	9.7
Skin	COLO849	9.8
Skin	G361	11.2
Skin	GRM	11.6
Skin	HMCB	10.6
Skin	HS294T	9.4
Skin	HS600T	9.7
Skin	HS688AT	9.2
Skin	HS695T	9.7
Skin	HS839T	9.6
Skin	HS852T	10.6
Skin	HS895T	9.8
Skin	HS934T	9.9
Skin	HS936T	9.3
Skin	HS939T	10.2
Skin	HS940T	9.3
Skin	HS944T	10.8
Skin	HT144	10.3
Skin	IGR1	9
Skin	IGR37	10.7
Skin	IGR39	11.1
Skin	IPC298	10.3
Skin	K029AX	10.2
Skin	LOXIMVI	10.2
Skin	MALME3M	9.5
Skin	MDAMB435S	9.7
Skin	MELHO	10
Skin	MELJUSO	11.1
Skin	MEWO	9.9
Skin	RPMI7951	10.2
Skin	RVH421	9.7
Skin	SH4	10.2
Skin	SKMEL1	9.4
Skin	SKMEL24	9
Skin	SKMEL28	10.2
Skin	SKMEL2	10.3
Skin	SKMEL30	10.4
Skin	SKMEL31	9.2
Skin	SKMEL3	9.9
Skin	SKMEL5	10.5
Skin	UACC257	9.6
Skin	UACC62	10
Skin	WM115	9.6
Skin	WM1799	9.5
Skin	WM2664	9.5
Skin	WM793	9.8
Skin	WM88	9.4
Skin	WM983B	10.7
Small intestine	HUTU80	10.1
Soft tissue	A204	10.3
Soft tissue	G401	10.2
Soft tissue	G402	10.4
Soft tissue	GCT	9.9
Soft tissue	HS729	10.3
Soft tissue	HT1080	10.5
Soft tissue	KYM1	10.3
Soft tissue	MESSA	10
Soft tissue	RD	11.1
Soft tissue	RH30	12.1
Soft tissue	RH41	11.3
Soft tissue	RKN	10.3
Soft tissue	S117	9.9
Soft tissue	SJRH30	10.7
Soft tissue	SKLMS1	9.9
Soft tissue	SKUT1	10.8
Soft tissue	TE125T	9.8
Soft tissue	TE159T	9.1
Soft tissue	TE441T	11
Soft tissue	TE617T	10.1
Stomach	2313287	10.1
Stomach	AGS	10.1
Stomach	AZ521	11
Stomach	ECC10	10.2
Stomach	ECC12	10.3
Stomach	FU97	9.5
Stomach	GCIY	10.9
Stomach	GSS	10.3
Stomach	GSU	10.4
Stomach	HGC27	11.4
Stomach	HS746T	10.6
Stomach	HUG1N	10.5
Stomach	IM95	10.6
Stomach	KATOIII	10.7
Stomach	KE39	10.4
Stomach	LMSU	10.6
Stomach	MKN1	11
Stomach	MKN45	10
Stomach	MKN74	10.9
Stomach	MKN7	10.7
Stomach	NCCSTCK140	10.2
Stomach	NCIN87	10.7
Stomach	NUGC2	11.2
Stomach	NUGC3	9.6
Stomach	NUGC4	10
Stomach	OCUM1	10.2
Stomach	RERFGC1B	10.1
Stomach	SH10TC	10.3
Stomach	SNU16	10.4
Stomach	SNU1	10.5
Stomach	SNU216	9.9
Stomach	SNU520	10.2
Stomach	SNU5	10.6
Stomach	SNU601	9.7
Stomach	SNU620	11.4
Stomach	SNU668	10.1
Stomach	SNU719	9.6
Stomach	TGBC11TKB	10.3
Thyroid	8305C	10.9
Thyroid	8505C	11.2
Thyroid	BCPAP	8.9
Thyroid	BHT101	9.9
Thyroid	CAL62	10.5
Thyroid	CGTHW1	10.4
Thyroid	FTC133	10.7
Thyroid	FTC238	10.9
Thyroid	ML1	9.8
Thyroid	SW579	10.4
Thyroid	TT2609C02	11.4
Thyroid	TT	8.1
Upper aerodigestive tract	BHY	9.8
Upper aerodigestive tract	BICR16	11.2
Upper aerodigestive tract	BICR18	10.7
Upper aerodigestive tract	BICR22	10.2
Upper aerodigestive tract	BICR31	10
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	10.1
Upper aerodigestive tract	CAL27	10.5
Upper aerodigestive tract	CAL33	9.8
Upper aerodigestive tract	DETROIT562	11
Upper aerodigestive tract	FADU	10.4
Upper aerodigestive tract	HS840T	9.8
Upper aerodigestive tract	HSC2	9.5
Upper aerodigestive tract	HSC3	10.9
Upper aerodigestive tract	HSC4	9.9
Upper aerodigestive tract	PECAPJ15	9.4
Upper aerodigestive tract	PECAPJ34CLONEC12	11.1
Upper aerodigestive tract	PECAPJ41CLONED2	10
Upper aerodigestive tract	PECAPJ49	10.6
Upper aerodigestive tract	SCC15	10.5
Upper aerodigestive tract	SCC25	11
Upper aerodigestive tract	SCC4	9.9
Upper aerodigestive tract	SCC9	9.4
Upper aerodigestive tract	SNU1076	10.5
Upper aerodigestive tract	SNU1214	11.6
Upper aerodigestive tract	SNU46	10.7
Upper aerodigestive tract	SNU899	10.1
Upper aerodigestive tract	YD10B	10.5
Upper aerodigestive tract	YD38	10.9
Upper aerodigestive tract	YD8	9.9
Urinary tract	5637	11
Urinary tract	639V	9.4
Urinary tract	647V	10.2
Urinary tract	BC3C	11.5
Urinary tract	BFTC905	10.8
Urinary tract	CAL29	10.4
Urinary tract	HS172T	9.4
Urinary tract	HT1197	10.7
Urinary tract	HT1376	11
Urinary tract	J82	10.9
Urinary tract	JMSU1	11
Urinary tract	KMBC2	11
Urinary tract	KU1919	10.5
Urinary tract	RT11284	10.2
Urinary tract	RT112	10.6
Urinary tract	RT4	10.5
Urinary tract	SCABER	10
Urinary tract	SW1710	10.1
Urinary tract	SW780	9.5
Urinary tract	T24	10.5
Urinary tract	TCCSUP	10.4
Urinary tract	UMUC1	10.4
Urinary tract	UMUC3	10.1
Urinary tract	VMCUB1	9.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	29
Adrenal gland	37.9
Appendix	48.2
Bone marrow	69.3
Breast	39
Cerebral cortex	40.6
Cervix, uterine	39.1
Colon	29.8
Duodenum	26.3
Endometrium	42.2
Epididymis	31.2
Esophagus	36.8
Fallopian tube	45.6
Gallbladder	28.5
Heart muscle	16.9
Kidney	24.6
Liver	19.6
Lung	35.5
Lymph node	62.7
Ovary	27.7
Pancreas	5
Parathyroid gland	32.7
Placenta	38
Prostate	38.2
Rectum	36.9
Salivary gland	11.8
Seminal vesicle	31.6
Skeletal muscle	27.3
Skin	43.6
Small intestine	27
Smooth muscle	40.2
Spleen	43.4
Stomach	21.5
Testis	76.2
Thyroid gland	36.5
Tonsil	53.7
Urinary bladder	34.9

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.738	1.3e-70	41.8	44.6	13.6	Loss
BRCA	Breast invasive carcinoma	1075	0.548	2.97e-85	27.2	59.3	13.5	Neutral
CESC	Cervical and endocervical cancers	292	0.635	2.01e-34	18.2	65.1	16.8	Neutral
COAD	Colon adenocarcinoma	449	0.401	9.08e-19	12.9	72.6	14.5	Neutral
ESCA	Esophageal carcinoma	183	0.655	7.73e-24	29.5	43.2	27.3	Neutral
GBM	Glioblastoma multiforme	147	0.417	1.53e-07	12.9	70.7	16.3	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.684	2.78e-72	11.1	55.8	33.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.48	1.5e-31	28.4	69.1	2.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.402	1.22e-12	11.5	87.8	0.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.155	0.0466	1.2	98.2	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.427	3.83e-24	9.6	84.8	5.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.646	2.48e-44	31	61.8	7.1	Neutral
LUAD	Lung adenocarcinoma	512	0.462	1.82e-28	43.2	46.9	10	Loss
LUSC	Lung squamous cell carcinoma	498	0.568	6.12e-44	46.4	33.5	20.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.725	3.24e-50	48.7	37	14.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.322	1.24e-05	23.7	70.6	5.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.345	6.79e-06	6.2	92	1.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.582	7.08e-46	2.2	85.7	12	Neutral
READ	Rectum adenocarcinoma	164	0.554	1.33e-14	16.5	62.2	21.3	Neutral
SARC	Sarcoma	255	0.612	1.29e-27	12.9	51.4	35.7	Gain
SKCM	Skin Cutaneous Melanoma	367	0.577	5.14e-34	47.4	45.2	7.4	Loss
STAD	Stomach adenocarcinoma	413	0.569	7.71e-37	21.3	56.9	21.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.541	9.34e-13	38	48.7	13.3	Loss
THCA	Thyroid carcinoma	497	0.332	2.72e-14	5.6	93.6	0.8	Neutral
THYM	Thymoma	119	0.178	0.0524	1.7	89.9	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.395	1.74e-21	24	73.2	2.8	Neutral

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.316	3.41e-11	17	408	0.002	0.661	NS/NA
BRCA	Breast invasive carcinoma	-0.144	2.17e-05	83	785	0	0.489	NS/NA
CESC	Cervical and endocervical cancers	-0.277	8.37e-07	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.105	0.0632	19	297	-0.001	0.386	NS/NA
ESCA	Esophageal carcinoma	-0.229	0.00134	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.089	0.48	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.154	0.00033	20	522	0.001	0.00434	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.144	0.00743	24	319	0.004	2.55e-09	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.127	0.028	23	275	0.005	0.0338	NS/NA
LAML	Acute Myeloid Leukemia	-0.059	0.442	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.12	0.00583	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.2	4.39e-05	41	373	0.001	0.107	NS/NA
LUAD	Lung adenocarcinoma	-0.022	0.634	21	456	-0.016	0.00804	NS/NA
LUSC	Lung squamous cell carcinoma	-0.291	9.79e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.883	0.00308	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.118	0.11	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.074	0.315	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.103	0.0173	35	498	0.002	1.35e-07	NS/NA
READ	Rectum adenocarcinoma	-0.355	0.000295	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.302	6.98e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.403	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.181	0.000455	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.217	0.00669	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.082	0.054	50	509	0	0.18	NS/NA
THYM	Thymoma	-0.035	0.701	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.215	3.1e-06	34	431	-0.002	0.332	NS/NA

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	1	Low
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	0	Not detected
Esophagus	2	Medium
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	2	Medium
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	2	Medium
Nasopharynx	1	Low
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	1	Low
Testis	2	Medium
Thyroid gland	1	Low
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0105	Significant	24476821
BRCA	Breast invasive carcinoma	521	2e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0432	Significant	22810696
GBM	Glioblastoma multiforme	157	0.082	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0491	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0949	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.000108	Significant	26824661
LUAD	Lung adenocarcinoma	230	2.07e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	5.85e-09	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0259	Significant	21720365
PRAD	Prostate adenocarcinoma	333	5.2e-10	Significant	26544944
READ	Rectum adenocarcinoma	67	0.17	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0475	Significant	26091043
STAD	Stomach adenocarcinoma	277	2.31e-11	Significant	25079317
THCA	Thyroid carcinoma	391	0.000249	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0311	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.416	0.115	NS
BRCA	Breast invasive carcinoma	1079	0.996	0.986	NS
CESC	Cervical and endocervical cancers	291	0.506	0.0445	Longer
COAD	Colon adenocarcinoma	439	1.055	0.85	NS
ESCA	Esophageal carcinoma	184	0.664	0.247	NS
GBM	Glioblastoma multiforme	158	0.797	0.373	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.405	0.079	NS
KIRC	Kidney renal clear cell carcinoma	531	0.461	0.000155	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.131	0.778	NS
LAML	Acute Myeloid Leukemia	149	0.743	0.329	NS
LGG	Brain Lower Grade Glioma	511	1.379	0.19	NS
LIHC	Liver hepatocellular carcinoma	365	1.618	0.0602	NS
LUAD	Lung adenocarcinoma	502	1.4	0.114	NS
LUSC	Lung squamous cell carcinoma	494	0.943	0.763	NS
OV	Ovarian serous cystadenocarcinoma	303	0.752	0.16	NS
PAAD	Pancreatic adenocarcinoma	177	1.459	0.233	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.631	0.589	NS
PRAD	Prostate adenocarcinoma	497	2.65	0.22	NS
READ	Rectum adenocarcinoma	159	0.653	0.464	NS
SARC	Sarcoma	259	1.164	0.573	NS
SKCM	Skin Cutaneous Melanoma	459	1.167	0.433	NS
STAD	Stomach adenocarcinoma	388	0.752	0.194	NS
TGCT	Testicular Germ Cell Tumors	134	1.68	0.672	NS
THCA	Thyroid carcinoma	500	0.763	0.702	NS
THYM	Thymoma	119	0.222	0.157	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.743	0.368	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.001	0.983	NS
BRCA	Breast invasive carcinoma	1071	-0.006	0.852	NS
CESC	Cervical and endocervical cancers	167	-0.159	0.0407	Lower
COAD	Colon adenocarcinoma	445	-0.044	0.354	NS
ESCA	Esophageal carcinoma	162	-0.057	0.472	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.082	0.0841	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.143	0.000938	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.065	0.296	NS
LIHC	Liver hepatocellular carcinoma	347	0.116	0.0305	Higher
LUAD	Lung adenocarcinoma	507	0.101	0.0233	Higher
LUSC	Lung squamous cell carcinoma	497	0.077	0.0865	NS
OV	Ovarian serous cystadenocarcinoma	302	0.042	0.469	NS
PAAD	Pancreatic adenocarcinoma	176	0.095	0.208	NS
READ	Rectum adenocarcinoma	156	-0.02	0.807	NS
SKCM	Skin Cutaneous Melanoma	410	-0.098	0.0477	Lower
STAD	Stomach adenocarcinoma	392	-0.033	0.517	NS
TGCT	Testicular Germ Cell Tumors	81	-0.257	0.0206	Lower
THCA	Thyroid carcinoma	499	0.122	0.00632	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.028	0.53	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.005	0.934	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.164	0.000237	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.123	0.00486	Lower
LGG	Brain Lower Grade Glioma	514	0.179	4.33e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	0.132	0.0118	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.048	0.408	NS
PAAD	Pancreatic adenocarcinoma	176	0.078	0.304	NS
STAD	Stomach adenocarcinoma	406	-0.009	0.86	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.227	1.19e-07	Higher

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB00242	Cladribine	Small Molecule Drug

Summary
Symbol	POLE3
Name	DNA polymerase epsilon 3, accessory subunit
Aliases	CHRAC17; Ybl1; CHARAC17; histone fold protein CHRAC17; DNA polymerase epsilon p17 subunit; chromatin accessi ......
Location	9q32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for POLE3.