CR2Cancer

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00856 SET domain

Function

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor	Histone methylation	H3K9	H3K9me	23856557

> Gene Ontology [ TOP ]
Biological Process	GO:0001654 eye development GO:0001701 in utero embryonic development GO:0001754 eye photoreceptor cell differentiation GO:0001763 morphogenesis of a branching structure GO:0001779 natural killer cell differentiation GO:0001865 NK T cell differentiation GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001893 maternal placenta development GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0003170 heart valve development GO:0003205 cardiac chamber development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0007159 leukocyte cell-cell adhesion GO:0007281 germ cell development GO:0007423 sensory organ development GO:0007507 heart development GO:0007565 female pregnancy GO:0009791 post-embryonic development GO:0022407 regulation of cell-cell adhesion GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030098 lymphocyte differentiation GO:0030101 natural killer cell activation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030888 regulation of B cell proliferation GO:0030889 negative regulation of B cell proliferation GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0032102 negative regulation of response to external stimulus GO:0032259 methylation GO:0032496 response to lipopolysaccharide GO:0032814 regulation of natural killer cell activation GO:0032823 regulation of natural killer cell differentiation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0033078 extrathymic T cell differentiation GO:0033082 regulation of extrathymic T cell differentiation GO:0035904 aorta development GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042461 photoreceptor cell development GO:0042462 eye photoreceptor cell development GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0044706 multi-multicellular organism process GO:0045165 cell fate commitment GO:0045577 regulation of B cell differentiation GO:0045579 positive regulation of B cell differentiation GO:0045580 regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0046530 photoreceptor cell differentiation GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0048514 blood vessel morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048608 reproductive structure development GO:0048844 artery morphogenesis GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050869 negative regulation of B cell activation GO:0050871 positive regulation of B cell activation GO:0051136 regulation of NK T cell differentiation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0055123 digestive system development GO:0060135 maternal process involved in female pregnancy GO:0060575 intestinal epithelial cell differentiation GO:0060576 intestinal epithelial cell development GO:0060706 cell differentiation involved in embryonic placenta development GO:0060707 trophoblast giant cell differentiation GO:0060840 artery development GO:0060976 coronary vasculature development GO:0061458 reproductive system development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0090596 sensory organ morphogenesis GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1990654 sebum secreting cell proliferation
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0008168 methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0042826 histone deacetylase binding GO:1990841 promoter-specific chromatin binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804754: Regulation of TP53 Expression R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5946362	c.71_85del15	p.I25_H29delIVNDH	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM5582225	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM1071744	c.1245C>T	p.L415L	Substitution - coding silent	Endometrium
COSM1439505	c.2118C>T	p.L706L	Substitution - coding silent	Large_intestine
COSM97134	c.733_734delGA	p.D245fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM225242	c.247G>A	p.E83K	Substitution - Missense	Skin
COSM4160094	c.501C>G	p.D167E	Substitution - Missense	Thyroid
COSM1439493	c.227G>A	p.R76H	Substitution - Missense	Large_intestine
COSM5615578	c.109G>T	p.G37C	Substitution - Missense	Lung
COSM213669	c.1433G>A	p.S478N	Substitution - Missense	Breast
COSM4914833	c.1753C>T	p.H585Y	Substitution - Missense	Liver
COSM450260	c.353A>G	p.E118G	Substitution - Missense	Breast
COSM3619177	c.666C>T	p.S222S	Substitution - coding silent	Skin
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM97176	c.125_128delAGGC	p.Q42fs*23	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM450262	c.939C>G	p.S313R	Substitution - Missense	Breast
COSM97156	c.632_633delAG	p.E211fs*23	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5731143	c.221_222insCACA	p.R76fs*9	Insertion - Frameshift	Breast
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM97137	c.183G>C	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4562964	c.842G>A	p.G281E	Substitution - Missense	Skin
COSM1697721	c.15G>A	p.M5I	Substitution - Missense	Skin
COSM3619185	c.989G>A	p.G330D	Substitution - Missense	Skin
COSM329558	c.1979A>G	p.Y660C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5955072	c.276G>A	p.K92K	Substitution - coding silent	Upper_aerodigestive_tract
COSM5019273	c.2034G>A	p.P678P	Substitution - coding silent	Thyroid
COSM483226	c.1459G>A	p.A487T	Substitution - Missense	Kidney
COSM1071740	c.1040C>T	p.T347M	Substitution - Missense	Skin
COSM4717433	c.606C>A	p.L202L	Substitution - coding silent	Large_intestine
COSM3154324	c.1448C>T	p.A483V	Substitution - Missense	Oesophagus
COSM4776130	c.1925A>C	p.K642T	Substitution - Missense	Soft_tissue
COSM5723832	c.1618G>A	p.E540K	Substitution - Missense	Skin
COSM450261	c.496C>T	p.R166W	Substitution - Missense	Breast
COSM3619197	c.1537C>T	p.L513F	Substitution - Missense	Skin
COSM4406870	c.953G>A	p.S318N	Substitution - Missense	Soft_tissue
COSM97155	c.357_358delAA	p.S120fs*32	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3154266	c.226C>T	p.R76C	Substitution - Missense	Large_intestine
COSM3619175	c.646G>A	p.E216K	Substitution - Missense	Skin
COSM5404104	c.1055C>T	p.S352F	Substitution - Missense	Skin
COSM1071750	c.2126T>C	p.V709A	Substitution - Missense	Endometrium
COSM99132	c.1794+2T>A	p.V599fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3619171	c.400G>A	p.E134K	Substitution - Missense	Skin
COSM97164	c.111_111C>GG	p.T39fs*22	Complex - frameshift	Haematopoietic_and_lymphoid_tissue
COSM4992388	c.2292G>T	p.M764I	Substitution - Missense	Skin
COSM97173	c.2036C>T	p.A679V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM97179	c.37_38delTG	p.W13fs*4	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM298374	c.968C>T	p.T323M	Substitution - Missense	Large_intestine
COSM5709785	c.497_507del11	p.D167fs*28	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5787479	c.417G>A	p.A139A	Substitution - coding silent	Breast
COSM1071748	c.1611C>A	p.I537I	Substitution - coding silent	Endometrium
COSM5645042	c.2183G>C	p.R728T	Substitution - Missense	Oesophagus
COSM5404102	c.1032C>T	p.S344S	Substitution - coding silent	Skin
COSM739796	c.497G>C	p.R166P	Substitution - Missense	Lung
COSM5809936	c.1478T>A	p.V493E	Substitution - Missense	Liver
COSM1754402	c.137C>G	p.S46C	Substitution - Missense	Urinary_tract
COSM1620720	c.661G>T	p.D221Y	Substitution - Missense	Liver
COSM364706	c.1106C>T	p.S369L	Substitution - Missense	Lung
COSM97137	c.183G>C	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4992384	c.1334C>T	p.P445L	Substitution - Missense	Skin
COSM3381393	c.287G>T	p.R96M	Substitution - Missense	Pancreas
COSM1221867	c.835G>A	p.A279T	Substitution - Missense	Large_intestine
COSM4717437	c.1564G>A	p.G522S	Substitution - Missense	Large_intestine
COSM163703	c.2119G>A	p.E707K	Substitution - Missense	Breast
COSM3619167	c.288G>A	p.R96R	Substitution - coding silent	Skin
COSM1294194	c.421C>G	p.Q141E	Substitution - Missense	Cervix
COSM3154295	c.869G>A	p.R290H	Substitution - Missense	Stomach
COSM5061313	c.1843C>T	p.R615*	Substitution - Nonsense	Stomach
COSM5720735	c.1940G>T	p.R647L	Substitution - Missense	Skin
COSM4531489	c.1685G>A	p.S562N	Substitution - Missense	Skin
COSM5486509	c.1338G>A	p.E446E	Substitution - coding silent	Large_intestine
COSM5752561	c.2259C>A	p.C753*	Substitution - Nonsense	Breast
COSM4160096	c.1078C>T	p.P360S	Substitution - Missense	Thyroid
COSM4461497	c.1101C>T	p.I367I	Substitution - coding silent	Skin
COSM4930310	c.125A>T	p.Q42L	Substitution - Missense	Liver
COSM97165	c.903_904insC	p.S302fs*86	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1754404	c.540G>A	p.L180L	Substitution - coding silent	Urinary_tract
COSM4170089	c.1618_1619insA	p.C541fs*56	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3857242	c.1421G>A	p.C474Y	Substitution - Missense	Stomach
COSM5369350	c.528T>G	p.Y176*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM97169	c.445T>G	p.Y149D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4433315	c.778C>T	p.R260W	Substitution - Missense	Oesophagus
COSM5404100	c.205G>A	p.E69K	Substitution - Missense	Skin
COSM1262935	c.869G>T	p.R290L	Substitution - Missense	Oesophagus
COSM4155939	c.304-3C>T	p.?	Unknown	Kidney
COSM5677910	c.2249C>G	p.S750C	Substitution - Missense	Soft_tissue
COSM4139031	c.556+8G>T	p.?	Unknown	Ovary
COSM5720733	c.1513C>T	p.P505S	Substitution - Missense	Skin
COSM3619179	c.791C>T	p.P264L	Substitution - Missense	Skin
COSM97174	c.1412A>C	p.D471A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4759860	c.1015G>A	p.A339T	Substitution - Missense	Stomach
COSM3619199	c.1808G>A	p.R603K	Substitution - Missense	Skin
COSM4847066	c.2010G>A	p.L670L	Substitution - coding silent	Cervix
COSM97172	c.306C>G	p.I102M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1634409	c.951C>A	p.H317Q	Substitution - Missense	Liver
COSM739791	c.2127G>T	p.V709V	Substitution - coding silent	Lung
COSM4881006	c.362A>C	p.N121T	Substitution - Missense	Prostate
COSM3154347	c.1885C>T	p.P629S	Substitution - Missense	Large_intestine
COSM3154291	c.626_627delAG	p.E211fs*23	Deletion - Frameshift	Large_intestine
COSM1071737	c.205G>T	p.E69*	Substitution - Nonsense	Endometrium
COSM4901557	c.707C>T	p.S236L	Substitution - Missense	Skin
COSM97137	c.183G>C	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3619205	c.2015G>A	p.G672E	Substitution - Missense	Skin
COSM3619173	c.558A>T	p.T186T	Substitution - coding silent	Skin
COSM97175	c.1335_1336insA	p.E446fs*30	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5507609	c.2013A>T	p.K671N	Substitution - Missense	Biliary_tract
COSM4480363	c.2303C>T	p.P768L	Substitution - Missense	Skin
COSM5019273	c.2034G>A	p.P678P	Substitution - coding silent	Soft_tissue
COSM5357794	c.667A>G	p.N223D	Substitution - Missense	Large_intestine
COSM4160094	c.501C>G	p.D167E	Substitution - Missense	Liver
COSM5688063	c.497G>A	p.R166Q	Substitution - Missense	Soft_tissue
COSM3619195	c.1419C>T	p.A473A	Substitution - coding silent	Skin
COSM483226	c.1459G>A	p.A487T	Substitution - Missense	Large_intestine
COSM3920557	c.233G>A	p.G78E	Substitution - Missense	Skin
COSM1697723	c.38G>A	p.W13*	Substitution - Nonsense	Skin
COSM1620722	c.756C>T	p.S252S	Substitution - coding silent	Liver
COSM4789026	c.1928G>A	p.R643H	Substitution - Missense	Prostate
COSM739793	c.1772G>A	p.G591E	Substitution - Missense	Lung
COSM3619183	c.963G>A	p.G321G	Substitution - coding silent	Skin
COSM5709781	c.301_302insG	p.I102fs*12	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3947864	c.1555A>G	p.N519D	Substitution - Missense	Lung
COSM3619203	c.1961C>T	p.S654F	Substitution - Missense	Skin
COSM1487090	c.1742A>G	p.H581R	Substitution - Missense	Breast
COSM5627935	c.2188G>C	p.E730Q	Substitution - Missense	Oesophagus
COSM3154324	c.1448C>T	p.A483V	Substitution - Missense	Large_intestine
COSM5061311	c.847G>A	p.E283K	Substitution - Missense	Stomach
COSM3154303	c.1148G>A	p.G383D	Substitution - Missense	Central_nervous_system
COSM5894401	c.1382C>T	p.S461F	Substitution - Missense	Skin
COSM4968234	c.1750A>T	p.K584*	Substitution - Nonsense	Adrenal_gland
COSM1620732	c.1515C>A	p.P505P	Substitution - coding silent	Liver
COSM1684825	c.721G>T	p.E241*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3920559	c.732C>T	p.L244L	Substitution - coding silent	Skin
COSM4950574	c.1574C>A	p.T525N	Substitution - Missense	Liver
COSM1754406	c.549G>A	p.M183I	Substitution - Missense	Urinary_tract
COSM5474855	c.234A>G	p.G78G	Substitution - coding silent	Large_intestine
COSM3619205	c.2015G>A	p.G672E	Substitution - Missense	Skin
COSM5505200	c.622C>A	p.P208T	Substitution - Missense	Biliary_tract
COSM5723832	c.1618G>A	p.E540K	Substitution - Missense	Skin
COSM5404106	c.1618G>C	p.E540Q	Substitution - Missense	Skin
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM1262934	c.1262C>A	p.P421H	Substitution - Missense	Oesophagus
COSM739790	c.2279A>C	p.D760A	Substitution - Missense	Lung
COSM421118	c.1003C>A	p.R335R	Substitution - coding silent	Urinary_tract
COSM4636755	c.1089G>A	p.P363P	Substitution - coding silent	Large_intestine
COSM1754404	c.540G>A	p.L180L	Substitution - coding silent	Urinary_tract
COSM4139254	c.997G>A	p.E333K	Substitution - Missense	Pancreas
COSM4160098	c.1545A>T	p.K515N	Substitution - Missense	Thyroid
COSM1620730	c.1435delG	p.S480fs*32	Deletion - Frameshift	Liver
COSM234026	c.183+4A>G	p.?	Unknown	Skin
COSM1620724	c.784G>A	p.V262I	Substitution - Missense	Liver
COSM3619167	c.288G>A	p.R96R	Substitution - coding silent	Skin
COSM97167	c.557_567del11	p.T186fs*9	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1620720	c.661G>T	p.D221Y	Substitution - Missense	Liver
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5029692	c.1158T>C	p.C386C	Substitution - coding silent	Bone
COSM5019273	c.2034G>A	p.P678P	Substitution - coding silent	Soft_tissue
COSM4900370	c.1608G>A	p.K536K	Substitution - coding silent	Skin
COSM1672655	c.1924A>G	p.K642E	Substitution - Missense	Ovary
COSM5727425	c.84C>A	p.D28E	Substitution - Missense	Skin
COSM3857244	c.1627G>A	p.V543I	Substitution - Missense	Stomach
COSM97134	c.733_734delGA	p.D245fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3619181	c.846C>T	p.I282I	Substitution - coding silent	Skin
COSM72279	c.976C>T	p.P326S	Substitution - Missense	Ovary
COSM1754406	c.549G>A	p.M183I	Substitution - Missense	Urinary_tract
COSM4934690	c.876C>T	p.P292P	Substitution - coding silent	Liver
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM4586115	c.1142C>G	p.P381R	Substitution - Missense	Bone
COSM739797	c.181G>A	p.E61K	Substitution - Missense	Lung
COSM4717435	c.1035C>T	p.Y345Y	Substitution - coding silent	Large_intestine
COSM450263	c.1494C>A	p.T498T	Substitution - coding silent	Breast
COSM5582227	c.896C>T	p.P299L	Substitution - Missense	Skin
COSM97161	c.55_56ins10	p.E19fs*2	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4477860	c.2082C>T	p.I694I	Substitution - coding silent	Skin
COSM4745782	c.1565G>A	p.G522D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM109801	c.2170C>T	p.L724L	Substitution - coding silent	Skin
COSM3154276	c.425A>G	p.N142S	Substitution - Missense	Large_intestine
COSM5720735	c.1940G>T	p.R647L	Substitution - Missense	Skin
COSM97173	c.2036C>T	p.A679V	Substitution - Missense	Stomach
COSM3619171	c.400G>A	p.E134K	Substitution - Missense	Skin
COSM263087	c.2194G>T	p.E732*	Substitution - Nonsense	Large_intestine
COSM450265	c.1633G>A	p.A545T	Substitution - Missense	Breast
COSM4779054	c.1184T>C	p.M395T	Substitution - Missense	Liver
COSM4160094	c.501C>G	p.D167E	Substitution - Missense	Soft_tissue
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM97134	c.733_734delGA	p.D245fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5737716	c.1304C>A	p.P435H	Substitution - Missense	Small_intestine
COSM4789026	c.1928G>A	p.R643H	Substitution - Missense	Liver
COSM5019273	c.2034G>A	p.P678P	Substitution - coding silent	Soft_tissue
COSM4717439	c.2174C>T	p.A725V	Substitution - Missense	Large_intestine
COSM421119	c.413C>A	p.A138D	Substitution - Missense	Urinary_tract
COSM298374	c.968C>T	p.T323M	Substitution - Missense	Large_intestine
COSM97134	c.733_734delGA	p.D245fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5822593	c.294T>A	p.Y98*	Substitution - Nonsense	Liver
COSM1439501	c.748C>T	p.R250C	Substitution - Missense	Large_intestine
COSM5982021	c.?	p.L414P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1158959	c.517_523delCACTACC	p.H173fs*6	Deletion - Frameshift	Pancreas
COSM450266	c.1644C>T	p.F548F	Substitution - coding silent	Breast
COSM4939559	c.1500A>T	p.A500A	Substitution - coding silent	Liver
COSM5019273	c.2034G>A	p.P678P	Substitution - coding silent	Soft_tissue
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5700064	c.242T>C	p.I81T	Substitution - Missense	Soft_tissue
COSM5731081	c.1806G>C	p.K602N	Substitution - Missense	Breast
COSM5986717	c.?	p.E17D	Substitution - Missense	Salivary_gland
COSM5026610	c.1662G>A	p.L554L	Substitution - coding silent	Breast
COSM3154276	c.425A>G	p.N142S	Substitution - Missense	Large_intestine
COSM1071745	c.1343C>A	p.P448H	Substitution - Missense	Endometrium
COSM5720735	c.1940G>T	p.R647L	Substitution - Missense	Skin
COSM3828714	c.601G>A	p.E201K	Substitution - Missense	Breast
COSM3619189	c.1107G>A	p.S369S	Substitution - coding silent	Skin
COSM4992386	c.1450G>A	p.G484R	Substitution - Missense	Skin
COSM3975702	c.2176G>A	p.V726M	Substitution - Missense	Central_nervous_system
COSM229014	c.1403G>A	p.S468N	Substitution - Missense	Skin
COSM4160094	c.501C>G	p.D167E	Substitution - Missense	Soft_tissue
COSM1439502	c.754A>G	p.S252G	Substitution - Missense	Large_intestine
COSM1620726	c.911G>A	p.R304K	Substitution - Missense	Liver
COSM97025	c.522C>A	p.Y174*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3920563	c.1860G>A	p.E620E	Substitution - coding silent	Skin
COSM99131	c.303+1G>T	p.R101fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM97158	c.1810_1819del10	p.F604fs*32	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1262936	c.717A>G	p.T239T	Substitution - coding silent	Oesophagus
COSM3154293	c.695G>A	p.R232H	Substitution - Missense	Urinary_tract
COSM3920561	c.1844G>A	p.R615Q	Substitution - Missense	Skin
COSM1439484	c.14T>C	p.M5T	Substitution - Missense	Large_intestine
COSM3780833	c.1260G>T	p.L420L	Substitution - coding silent	Pancreas
COSM3619211	c.2239G>A	p.G747R	Substitution - Missense	Skin
COSM4992382	c.685G>A	p.D229N	Substitution - Missense	Skin
COSM97178	c.175_176insCACCAACA	p.S59fs*10	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1071742	c.1132C>T	p.L378F	Substitution - Missense	Endometrium
COSM100048	c.1565_1665+144del245	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1262937	c.640G>A	p.V214M	Substitution - Missense	Oesophagus
COSM5026608	c.1312G>A	p.G438R	Substitution - Missense	Breast
COSM1287362	c.904T>C	p.S302P	Substitution - Missense	Autonomic_ganglia
COSM1620724	c.784G>A	p.V262I	Substitution - Missense	Liver
COSM5797084	c.805C>G	p.L269V	Substitution - Missense	Breast
COSM593673	c.779G>T	p.R260L	Substitution - Missense	Oesophagus
COSM4789026	c.1928G>A	p.R643H	Substitution - Missense	Liver
COSM1071747	c.1602C>T	p.N534N	Substitution - coding silent	Endometrium
COSM4139031	c.556+8G>T	p.?	Unknown	Ovary
COSM4477860	c.2082C>T	p.I694I	Substitution - coding silent	Skin
COSM5720735	c.1940G>T	p.R647L	Substitution - Missense	Skin
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM4918711	c.588C>T	p.S196S	Substitution - coding silent	Liver
COSM1071740	c.1040C>T	p.T347M	Substitution - Missense	Endometrium
COSM1262937	c.640G>A	p.V214M	Substitution - Missense	Stomach
COSM3154282	c.554T>G	p.L185R	Substitution - Missense	Large_intestine
COSM3619169	c.312C>T	p.S104S	Substitution - coding silent	Skin
COSM450264	c.1521C>A	p.S507R	Substitution - Missense	Breast
COSM5956104	c.1676G>T	p.R559I	Substitution - Missense	Upper_aerodigestive_tract
COSM99134	c.183+2T>G	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM97026	c.609C>A	p.C203*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5043500	c.1367C>A	p.P456H	Substitution - Missense	Liver
COSM1581518	c.823A>C	p.K275Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3857236	c.635A>G	p.Y212C	Substitution - Missense	Stomach
COSM100049	c.556+1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM298374	c.968C>T	p.T323M	Substitution - Missense	Endometrium
COSM5977649	c.23C>T	p.A8V	Substitution - Missense	Central_nervous_system
COSM5943533	c.840delC	p.Y280fs*1	Deletion - Frameshift	Skin
COSM1071741	c.1084C>T	p.L362F	Substitution - Missense	Endometrium
COSM5023920	c.469A>G	p.N157D	Substitution - Missense	Bone
COSM5946380	c.1619A>G	p.E540G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3619187	c.1087C>T	p.P363S	Substitution - Missense	Skin
COSM97168	c.143C>G	p.P48R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM99134	c.183+2T>G	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3619201	c.1849C>T	p.H617Y	Substitution - Missense	Skin
COSM3619191	c.1131C>T	p.F377F	Substitution - coding silent	Skin
COSM5723832	c.1618G>A	p.E540K	Substitution - Missense	Skin
COSM383467	c.1326G>T	p.L442F	Substitution - Missense	Lung
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM3723182	c.1704A>T	p.K568N	Substitution - Missense	Upper_aerodigestive_tract
COSM100050	c.303+1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1071739	c.894T>C	p.T298T	Substitution - coding silent	Endometrium
COSM4170091	c.1694delG	p.P566fs*73	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM97157	c.594_595delGA	p.N200fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4426653	c.114T>A	p.G38G	Substitution - coding silent	Oesophagus
COSM4759862	c.1733A>C	p.Q578P	Substitution - Missense	Stomach
COSM5975727	c.906T>C	p.S302S	Substitution - coding silent	Upper_aerodigestive_tract
COSM97159	c.646G>T	p.E216*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3857238	c.686A>G	p.D229G	Substitution - Missense	Stomach
COSM5061309	c.176G>A	p.S59N	Substitution - Missense	Stomach
COSM1620726	c.911G>A	p.R304K	Substitution - Missense	Liver
COSM299892	c.1893G>A	p.K631K	Substitution - coding silent	Large_intestine
COSM97138	c.184-1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5817246	c.1447G>C	p.A483P	Substitution - Missense	Liver
COSM97171	c.1706G>A	p.C569Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5720733	c.1513C>T	p.P505S	Substitution - Missense	Skin
COSM3619181	c.846C>T	p.I282I	Substitution - coding silent	Skin
COSM1620728	c.1261C>T	p.P421S	Substitution - Missense	Liver
COSM276884	c.119C>T	p.S40L	Substitution - Missense	Large_intestine
COSM227275	c.101G>A	p.G34D	Substitution - Missense	Skin
COSM5709787	c.1260_1261insCC	p.H422fs*49	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM421118	c.1003C>A	p.R335R	Substitution - coding silent	Endometrium
COSM1620722	c.756C>T	p.S252S	Substitution - coding silent	Liver
COSM97181	c.37_183+46del193	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1620732	c.1515C>A	p.P505P	Substitution - coding silent	Liver
COSM5709783	c.363_393del31	p.W122fs*13	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1684826	c.1708C>T	p.Q570*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM97177	c.578_579insA	p.Q194fs*5	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5492125	c.1920G>A	p.L640L	Substitution - coding silent	Biliary_tract
COSM4406870	c.953G>A	p.S318N	Substitution - Missense	Liver
COSM4979514	c.532G>T	p.G178*	Substitution - Nonsense	Oesophagus
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3619209	c.2164G>A	p.E722K	Substitution - Missense	Skin
COSM4536357	c.2183G>A	p.R728K	Substitution - Missense	Skin
COSM99134	c.183+2T>G	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1620728	c.1261C>T	p.P421S	Substitution - Missense	Liver
COSM1620720	c.661G>T	p.D221Y	Substitution - Missense	Liver
COSM1071738	c.371G>T	p.R124L	Substitution - Missense	Endometrium
COSM5720733	c.1513C>T	p.P505S	Substitution - Missense	Skin
COSM97180	c.76_95del20	p.V26fs*4	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4160094	c.501C>G	p.D167E	Substitution - Missense	Soft_tissue
COSM4431226	c.1246G>A	p.G416S	Substitution - Missense	Oesophagus
COSM3619207	c.2066G>A	p.R689Q	Substitution - Missense	Skin
COSM3726492	c.131A>T	p.E44V	Substitution - Missense	Lung
COSM739795	c.1051G>T	p.G351C	Substitution - Missense	Lung
COSM5404098	c.88C>T	p.P30S	Substitution - Missense	Skin
COSM97160	c.1747C>T	p.Q583*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5020312	c.2204G>A	p.G735D	Substitution - Missense	Soft_tissue
COSM99133	c.124_127delCAGG	p.Q42fs*23	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1262937	c.640G>A	p.V214M	Substitution - Missense	Large_intestine
COSM1439501	c.748C>T	p.R250C	Substitution - Missense	Large_intestine
COSM3781953	c.1489G>A	p.A497T	Substitution - Missense	Pancreas
COSM5497847	c.1498G>A	p.A500T	Substitution - Missense	Biliary_tract
COSM5723832	c.1618G>A	p.E540K	Substitution - Missense	Skin
COSM4992380	c.684G>A	p.K228K	Substitution - coding silent	Skin
COSM3719643	c.472C>A	p.Q158K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3857248	c.2307C>T	p.S769S	Substitution - coding silent	Stomach
COSM97137	c.183G>C	p.E61fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1439493	c.227G>A	p.R76H	Substitution - Missense	Large_intestine
COSM3697432	c.1366C>T	p.P456S	Substitution - Missense	Large_intestine
COSM97156	c.632_633delAG	p.E211fs*23	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM100051	c.1_2370del2370	p.0?	Whole gene deletion	Haematopoietic_and_lymphoid_tissue
COSM3619181	c.846C>T	p.I282I	Substitution - coding silent	Large_intestine
COSM1158959	c.517_523delCACTACC	p.H173fs*6	Deletion - Frameshift	Pancreas
COSM1071749	c.2022C>T	p.C674C	Substitution - coding silent	Endometrium
COSM3619193	c.1347G>A	p.R449R	Substitution - coding silent	Skin
COSM1754402	c.137C>G	p.S46C	Substitution - Missense	Urinary_tract
COSM4636755	c.1089G>A	p.P363P	Substitution - coding silent	Large_intestine
COSM5895283	c.1516_1526del11	p.S507fs*5	Deletion - Frameshift	Skin
COSM4424696	c.35T>A	p.L12Q	Substitution - Missense	Oesophagus
COSM4950574	c.1574C>A	p.T525N	Substitution - Missense	Liver
COSM3857234	c.128C>T	p.A43V	Substitution - Missense	Stomach
COSM5720733	c.1513C>T	p.P505S	Substitution - Missense	Skin
COSM329559	c.1673T>C	p.L558P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM97170	c.142C>A	p.P48T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM225242	c.247G>A	p.E83K	Substitution - Missense	Skin
COSM1071743	c.1163G>T	p.G388V	Substitution - Missense	Endometrium
COSM5785924	c.891C>A	p.T297T	Substitution - coding silent	Breast
COSM97162	c.183G>A	p.E62fs	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4512292	c.790C>T	p.P264S	Substitution - Missense	Skin
COSM3857246	c.2027C>T	p.A676V	Substitution - Missense	Stomach
COSM5713519	c.1064_1076del13	p.Y356fs*25	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3857240	c.1365G>A	p.A455A	Substitution - coding silent	Stomach
COSM1071746	c.1412A>G	p.D471G	Substitution - Missense	Endometrium
COSM4480363	c.2303C>T	p.P768L	Substitution - Missense	Skin
COSM97163	c.556+1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM97026	c.609C>A	p.C203*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3154317	c.1390G>A	p.G464R	Substitution - Missense	Stomach
COSM3975700	c.988G>T	p.G330C	Substitution - Missense	Central_nervous_system
COSM163704	c.2077G>C	p.E693Q	Substitution - Missense	Breast
COSM1439492	c.209A>G	p.Y70C	Substitution - Missense	Large_intestine
COSM139662	c.830C>T	p.S277F	Substitution - Missense	Skin
COSM5020484	c.1240C>T	p.L414F	Substitution - Missense	Soft_tissue

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27687004	mutation	Plasmablastic Lymphoma	Furthermore, we demonstrate that recurrent somatic mutations in PRDM1 are found in 50% of plasmablastic lymphoma cases (8 of 16 cases evaluated).
27144525	mutation	Carcinoma of the Collecting Ducts of Bellini	We identified somatic SNVs in 14 other cancer census genes including: ATM, CREBBP, PRDM1, CBFB, FBXW7, IKZF1, KDR, KRAS, NACA, NF2, NUP98, SS18, TP53, and ZNF521.
26111727	mutation	Central Nervous System Lymphoma	The results showed that 68 out of 71 PCNSLs had mutations in the NF-κB gene network, most commonly affecting CD79B (83%), MYD88 (76%), TBL1XR1 (23%), PRDM1 (20%) and CREBBP1 (20%).
25743686	mutation	Plasma Cell Myeloma	We successfully tracked clonal evolution and identified mutation acquisition and/or loss in FAM46C, FAT1, KRAS, NRAS, SPEN, PRDM1, NEB, and TP53 as well as two mutations in XBP1, a gene associated with bortezomib resistance.
24518206	mutation	Plasma Cell Myeloma	Rearrangements reposition MYC near a limited number of genes associated with conventional enhancers, but mostly with super-enhancers (e.g., IGH, IGL, IGK, NSMCE2, TXNDC5, FAM46C, FOXO3, IGJ, PRDM1).
24240734	mutation	Central Nervous System Lymphoma	Moreover, PCNSL cells show impaired IG class switch due to sμ region deletions, and PRDM1 mutations.
18596541	mutation (loss of function)	Central Nervous System Lymphoma	Direct sequencing of all coding exons of the PRDM1 gene identified deleterious mutations associated with abrogation of PRDM1 protein expression in 4 of 21 (19%) PCNSLs.
27687004	Mutation	Plasmablastic Lymphoma	Furthermore, we demonstrate that recurrent somatic mutations in PRDM1 are found in 50% of plasmablastic lymphoma cases (8 of 16 cases evaluated).
27568520	copy number loss; Mutation	Diffuse Large B-Cell Lymphoma	In addition, homozygous PRDM1 deletions and PRDM1 mutations within exons 1 and 2, which encode for domains crucial for transcriptional repression, were found to show a poor prognostic impact in patients with ABC-DLBCL but not in those with germinal center B-cell-like DLBCL (GCB-DLBCL).

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.705	4.107	-0.804	0.0226	Under
BRCA	Breast invasive carcinoma	112	1100	3.849	4.184	0.21	0.027	NS
CESC	Cervical and endocervical cancers	3	306	5.282	4.901	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.213	4.3	-0.784	3.09e-07	Under
ESCA	Esophageal carcinoma	11	185	5.015	5.694	0.845	0.0474	Over
GBM	Glioblastoma multiforme	5	166	2.048	3.213	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.707	5.652	-0.696	0.000114	Under
KIRC	Kidney renal clear cell carcinoma	72	534	2.786	5.282	2.332	9.33e-76	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	2.463	2.371	-0.078	0.783	NS
LAML	Acute Myeloid Leukemia	0	173	NA	3.868	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	2.571	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	1.991	1.631	-0.365	0.035	NS
LUAD	Lung adenocarcinoma	59	517	4.722	4.744	-0.028	0.85	NS
LUSC	Lung squamous cell carcinoma	51	501	5.097	5.153	0.075	0.608	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.551	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.386	4.538	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	1.849	3.153	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.231	2.827	-0.367	0.0427	NS
READ	Rectum adenocarcinoma	10	167	5.207	4.268	-0.743	0.0131	Under
SARC	Sarcoma	2	263	1.758	3.91	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.536	3.22	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.579	5.674	-0.407	0.0474	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.229	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.825	6.547	1.634	4.34e-27	Over
THYM	Thymoma	2	120	3.869	2.133	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.284	3.802	-0.896	4.75e-05	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	4.4
Autonomic ganglia	CHP212	6
Autonomic ganglia	IMR32	6.8
Autonomic ganglia	KELLY	4.6
Autonomic ganglia	KPNRTBM1	4.6
Autonomic ganglia	KPNSI9S	4.5
Autonomic ganglia	KPNYN	4.8
Autonomic ganglia	MHHNB11	4.6
Autonomic ganglia	NB1	5
Autonomic ganglia	NH6	4.6
Autonomic ganglia	SHSY5Y	4.4
Autonomic ganglia	SIMA	4.6
Autonomic ganglia	SKNAS	4.6
Autonomic ganglia	SKNBE2	5.2
Autonomic ganglia	SKNDZ	4.7
Autonomic ganglia	SKNFI	5.4
Autonomic ganglia	SKNSH	6.4
Biliary tract	HUCCT1	7
Biliary tract	HUH28	6.1
Biliary tract	SNU1079	4.5
Biliary tract	SNU1196	7
Biliary tract	SNU245	5.4
Biliary tract	SNU308	4.7
Biliary tract	SNU478	7.1
Bone	143B	5.9
Bone	A673	4.8
Bone	CADOES1	4.8
Bone	CAL78	6.3
Bone	G292CLONEA141B1	5.3
Bone	HOS	4.6
Bone	HS706T	5.3
Bone	HS737T	6
Bone	HS819T	5.9
Bone	HS821T	5
Bone	HS822T	5.7
Bone	HS863T	4.5
Bone	HS870T	5.5
Bone	HS888T	6.2
Bone	MG63	4.7
Bone	MHHES1	4.4
Bone	OUMS27	8.7
Bone	RDES	4.6
Bone	SJSA1	5.8
Bone	SKES1	4.8
Bone	SKNMC	4.2
Bone	SW1353	6.3
Bone	T173	5.8
Bone	TC71	4.7
Bone	U2OS	5.7
Breast	AU565	5.4
Breast	BT20	7.3
Breast	BT474	4.5
Breast	BT483	5
Breast	BT549	7.3
Breast	CAL120	5.7
Breast	CAL148	4.5
Breast	CAL51	5.8
Breast	CAL851	7.2
Breast	CAMA1	5.1
Breast	DU4475	5.2
Breast	EFM192A	4.5
Breast	EFM19	5.2
Breast	EVSAT	4.9
Breast	HCC1143	7.1
Breast	HCC1187	5.1
Breast	HCC1395	4.5
Breast	HCC1419	4.9
Breast	HCC1428	4.9
Breast	HCC1500	4.5
Breast	HCC1569	4.8
Breast	HCC1599	4.7
Breast	HCC1806	4.5
Breast	HCC1937	5.6
Breast	HCC1954	5.3
Breast	HCC202	4.8
Breast	HCC2157	5.2
Breast	HCC2218	5
Breast	HCC38	7.6
Breast	HCC70	6.1
Breast	HDQP1	6.1
Breast	HMC18	7.4
Breast	HS274T	5.1
Breast	HS281T	6.9
Breast	HS343T	6.4
Breast	HS578T	6.3
Breast	HS606T	6.3
Breast	HS739T	6.4
Breast	HS742T	5.7
Breast	JIMT1	5.2
Breast	KPL1	4.9
Breast	MCF7	5
Breast	MDAMB134VI	4.4
Breast	MDAMB157	6.3
Breast	MDAMB175VII	4.4
Breast	MDAMB231	5.5
Breast	MDAMB361	4.7
Breast	MDAMB415	5.7
Breast	MDAMB436	4.7
Breast	MDAMB453	5.6
Breast	MDAMB468	6.4
Breast	SKBR3	5
Breast	T47D	5.3
Breast	UACC812	4.6
Breast	UACC893	5.2
Breast	YMB1	5.2
Breast	ZR751	4.7
Breast	ZR7530	5
Central nervous system	1321N1	5.1
Central nervous system	42MGBA	6.8
Central nervous system	8MGBA	5.7
Central nervous system	A172	5
Central nervous system	AM38	7.3
Central nervous system	BECKER	5.2
Central nervous system	CAS1	6.6
Central nervous system	CCFSTTG1	7.2
Central nervous system	D283MED	5.4
Central nervous system	D341MED	4.8
Central nervous system	DAOY	5.2
Central nervous system	DBTRG05MG	6.3
Central nervous system	DKMG	5.7
Central nervous system	GAMG	4.5
Central nervous system	GB1	5.5
Central nervous system	GI1	5.8
Central nervous system	GMS10	6.4
Central nervous system	GOS3	5.8
Central nervous system	H4	7
Central nervous system	HS683	7.1
Central nervous system	KALS1	7.2
Central nervous system	KG1C	6.3
Central nervous system	KNS42	5.8
Central nervous system	KNS60	5.2
Central nervous system	KNS81	6.5
Central nervous system	KS1	5.2
Central nervous system	LN18	6.4
Central nervous system	LN229	5.2
Central nervous system	M059K	5.5
Central nervous system	MOGGCCM	7.6
Central nervous system	MOGGUVW	6.4
Central nervous system	NMCG1	7.3
Central nervous system	ONS76	4.4
Central nervous system	SF126	6.6
Central nervous system	SF295	6.4
Central nervous system	SNB19	6.8
Central nervous system	SNU1105	6.9
Central nervous system	SNU201	6.7
Central nervous system	SNU466	4.7
Central nervous system	SNU489	6.2
Central nervous system	SNU626	5.6
Central nervous system	SNU738	5.3
Central nervous system	SW1088	6.2
Central nervous system	SW1783	6.7
Central nervous system	T98G	7
Central nervous system	TM31	6.5
Central nervous system	U118MG	5.6
Central nervous system	U138MG	5.5
Central nervous system	U251MG	6
Central nervous system	U87MG	6.3
Central nervous system	YH13	6.3
Central nervous system	YKG1	6.1
Endometrium	AN3CA	4.7
Endometrium	COLO684	7.1
Endometrium	EFE184	5
Endometrium	EN	4.7
Endometrium	ESS1	5.1
Endometrium	HEC108	4.6
Endometrium	HEC151	5
Endometrium	HEC1A	4.7
Endometrium	HEC1B	4.9
Endometrium	HEC251	4.9
Endometrium	HEC265	4.7
Endometrium	HEC50B	4.6
Endometrium	HEC59	5.3
Endometrium	HEC6	4.6
Endometrium	ISHIKAWAHERAKLIO02ER	4.5
Endometrium	JHUEM1	4.7
Endometrium	JHUEM2	5.5
Endometrium	JHUEM3	5
Endometrium	KLE	4.7
Endometrium	MFE280	4.7
Endometrium	MFE296	4.9
Endometrium	MFE319	4.5
Endometrium	RL952	4.9
Endometrium	SNGM	5
Endometrium	SNU1077	5.8
Endometrium	SNU685	5.3
Endometrium	TEN	4.6
Haematopoietic and lymphoid	697	6.2
Haematopoietic and lymphoid	A3KAW	11.2
Haematopoietic and lymphoid	A4FUK	10.9
Haematopoietic and lymphoid	ALLSIL	5.1
Haematopoietic and lymphoid	AML193	6.2
Haematopoietic and lymphoid	AMO1	10.8
Haematopoietic and lymphoid	BCP1	10.7
Haematopoietic and lymphoid	BDCM	6.6
Haematopoietic and lymphoid	BL41	6.3
Haematopoietic and lymphoid	BL70	5
Haematopoietic and lymphoid	BV173	7
Haematopoietic and lymphoid	CA46	5.5
Haematopoietic and lymphoid	CI1	7.5
Haematopoietic and lymphoid	CMK115	4.7
Haematopoietic and lymphoid	CMK86	4.4
Haematopoietic and lymphoid	CMK	4.8
Haematopoietic and lymphoid	CMLT1	6.9
Haematopoietic and lymphoid	COLO775	9
Haematopoietic and lymphoid	DAUDI	5.4
Haematopoietic and lymphoid	DB	5.2
Haematopoietic and lymphoid	DEL	9.8
Haematopoietic and lymphoid	DND41	6.2
Haematopoietic and lymphoid	DOHH2	5.2
Haematopoietic and lymphoid	EB1	7.6
Haematopoietic and lymphoid	EB2	7.3
Haematopoietic and lymphoid	EHEB	9.1
Haematopoietic and lymphoid	EJM	10.9
Haematopoietic and lymphoid	EM2	5.8
Haematopoietic and lymphoid	EOL1	6.6
Haematopoietic and lymphoid	F36P	5
Haematopoietic and lymphoid	GA10	5
Haematopoietic and lymphoid	GDM1	5.9
Haematopoietic and lymphoid	GRANTA519	8.1
Haematopoietic and lymphoid	HDLM2	7.3
Haematopoietic and lymphoid	HDMYZ	6.8
Haematopoietic and lymphoid	HEL9217	4.9
Haematopoietic and lymphoid	HEL	5.1
Haematopoietic and lymphoid	HH	6.6
Haematopoietic and lymphoid	HL60	6.2
Haematopoietic and lymphoid	HPBALL	4.9
Haematopoietic and lymphoid	HS604T	7.4
Haematopoietic and lymphoid	HS611T	7
Haematopoietic and lymphoid	HS616T	5.1
Haematopoietic and lymphoid	HS751T	4.9
Haematopoietic and lymphoid	HT	5
Haematopoietic and lymphoid	HTK	5.5
Haematopoietic and lymphoid	HUNS1	6.8
Haematopoietic and lymphoid	HUT102	11.1
Haematopoietic and lymphoid	HUT78	6.9
Haematopoietic and lymphoid	JEKO1	5.7
Haematopoietic and lymphoid	JK1	6.6
Haematopoietic and lymphoid	JM1	5.4
Haematopoietic and lymphoid	JURKAT	5.7
Haematopoietic and lymphoid	JURLMK1	4.6
Haematopoietic and lymphoid	JVM2	10
Haematopoietic and lymphoid	JVM3	9.7
Haematopoietic and lymphoid	K562	5.2
Haematopoietic and lymphoid	KARPAS299	9.7
Haematopoietic and lymphoid	KARPAS422	5.8
Haematopoietic and lymphoid	KARPAS620	8.8
Haematopoietic and lymphoid	KASUMI1	5.1
Haematopoietic and lymphoid	KASUMI2	4.7
Haematopoietic and lymphoid	KASUMI6	6.2
Haematopoietic and lymphoid	KCL22	4.5
Haematopoietic and lymphoid	KE37	4.5
Haematopoietic and lymphoid	KE97	5.8
Haematopoietic and lymphoid	KG1	4.4
Haematopoietic and lymphoid	KHM1B	10.3
Haematopoietic and lymphoid	KIJK	10.6
Haematopoietic and lymphoid	KMH2	6.5
Haematopoietic and lymphoid	KMM1	10.2
Haematopoietic and lymphoid	KMS11	11.2
Haematopoietic and lymphoid	KMS12BM	9.3
Haematopoietic and lymphoid	KMS18	8.1
Haematopoietic and lymphoid	KMS20	10.6
Haematopoietic and lymphoid	KMS21BM	11.3
Haematopoietic and lymphoid	KMS26	10.7
Haematopoietic and lymphoid	KMS27	10.9
Haematopoietic and lymphoid	KMS28BM	11.3
Haematopoietic and lymphoid	KMS34	12
Haematopoietic and lymphoid	KO52	5
Haematopoietic and lymphoid	KOPN8	5.5
Haematopoietic and lymphoid	KU812	5.1
Haematopoietic and lymphoid	KYO1	4.9
Haematopoietic and lymphoid	L1236	7.9
Haematopoietic and lymphoid	L363	10
Haematopoietic and lymphoid	L428	8.7
Haematopoietic and lymphoid	L540	10.7
Haematopoietic and lymphoid	LAMA84	5.6
Haematopoietic and lymphoid	LOUCY	4.9
Haematopoietic and lymphoid	LP1	11.1
Haematopoietic and lymphoid	M07E	4.4
Haematopoietic and lymphoid	MC116	6.7
Haematopoietic and lymphoid	ME1	5.6
Haematopoietic and lymphoid	MEC1	7
Haematopoietic and lymphoid	MEC2	8.5
Haematopoietic and lymphoid	MEG01	5.2
Haematopoietic and lymphoid	MHHCALL2	4.9
Haematopoietic and lymphoid	MHHCALL3	5.1
Haematopoietic and lymphoid	MHHCALL4	4.9
Haematopoietic and lymphoid	MINO	6.6
Haematopoietic and lymphoid	MJ	10.3
Haematopoietic and lymphoid	MM1S	11.6
Haematopoietic and lymphoid	MOLM13	5.2
Haematopoietic and lymphoid	MOLM16	4.5
Haematopoietic and lymphoid	MOLM6	5.5
Haematopoietic and lymphoid	MOLP2	10.7
Haematopoietic and lymphoid	MOLP8	10.9
Haematopoietic and lymphoid	MOLT13	4.7
Haematopoietic and lymphoid	MOLT16	5.3
Haematopoietic and lymphoid	MOLT4	4.8
Haematopoietic and lymphoid	MONOMAC1	5.6
Haematopoietic and lymphoid	MONOMAC6	5.6
Haematopoietic and lymphoid	MOTN1	9.8
Haematopoietic and lymphoid	MUTZ5	6.3
Haematopoietic and lymphoid	MV411	5.6
Haematopoietic and lymphoid	NALM19	4.7
Haematopoietic and lymphoid	NALM1	5.9
Haematopoietic and lymphoid	NALM6	5.2
Haematopoietic and lymphoid	NAMALWA	5.2
Haematopoietic and lymphoid	NB4	5
Haematopoietic and lymphoid	NCIH929	11.5
Haematopoietic and lymphoid	NCO2	5.6
Haematopoietic and lymphoid	NOMO1	5.2
Haematopoietic and lymphoid	NUDHL1	6.7
Haematopoietic and lymphoid	NUDUL1	5.7
Haematopoietic and lymphoid	OCIAML2	6.4
Haematopoietic and lymphoid	OCIAML3	5.7
Haematopoietic and lymphoid	OCIAML5	5.6
Haematopoietic and lymphoid	OCILY10	4.9
Haematopoietic and lymphoid	OCILY19	7.5
Haematopoietic and lymphoid	OCILY3	9.3
Haematopoietic and lymphoid	OCIM1	5.1
Haematopoietic and lymphoid	OPM2	11.4
Haematopoietic and lymphoid	P12ICHIKAWA	5.1
Haematopoietic and lymphoid	P31FUJ	6.1
Haematopoietic and lymphoid	P3HR1	4.8
Haematopoietic and lymphoid	PCM6	10.6
Haematopoietic and lymphoid	PEER	4.7
Haematopoietic and lymphoid	PF382	4.6
Haematopoietic and lymphoid	PFEIFFER	7.4
Haematopoietic and lymphoid	PL21	5.8
Haematopoietic and lymphoid	RAJI	7.2
Haematopoietic and lymphoid	RCHACV	5.5
Haematopoietic and lymphoid	REC1	7
Haematopoietic and lymphoid	REH	4.7
Haematopoietic and lymphoid	RI1	6.6
Haematopoietic and lymphoid	RL	5.2
Haematopoietic and lymphoid	RPMI8226	9.2
Haematopoietic and lymphoid	RPMI8402	4.6
Haematopoietic and lymphoid	RS411	4.8
Haematopoietic and lymphoid	SEM	4.8
Haematopoietic and lymphoid	SET2	4.7
Haematopoietic and lymphoid	SIGM5	5.9
Haematopoietic and lymphoid	SKM1	6
Haematopoietic and lymphoid	SKMM2	10.7
Haematopoietic and lymphoid	SR786	9.7
Haematopoietic and lymphoid	ST486	6.6
Haematopoietic and lymphoid	SUDHL10	4.5
Haematopoietic and lymphoid	SUDHL1	7.2
Haematopoietic and lymphoid	SUDHL4	4.8
Haematopoietic and lymphoid	SUDHL5	4.9
Haematopoietic and lymphoid	SUDHL6	4.8
Haematopoietic and lymphoid	SUDHL8	5.7
Haematopoietic and lymphoid	SUPB15	6.4
Haematopoietic and lymphoid	SUPHD1	7.3
Haematopoietic and lymphoid	SUPM2	9.5
Haematopoietic and lymphoid	SUPT11	5.5
Haematopoietic and lymphoid	SUPT1	4.6
Haematopoietic and lymphoid	TALL1	4.8
Haematopoietic and lymphoid	TF1	5.5
Haematopoietic and lymphoid	THP1	6.8
Haematopoietic and lymphoid	TO175T	7.1
Haematopoietic and lymphoid	TOLEDO	5.9
Haematopoietic and lymphoid	U266B1	10.6
Haematopoietic and lymphoid	U937	6
Haematopoietic and lymphoid	UT7	5.2
Haematopoietic and lymphoid	WSUDLCL2	5.3
Kidney	769P	5
Kidney	786O	4.7
Kidney	A498	5.6
Kidney	A704	5.2
Kidney	ACHN	4.5
Kidney	BFTC909	5
Kidney	CAKI1	4.8
Kidney	CAKI2	4.8
Kidney	CAL54	4.5
Kidney	KMRC1	6.2
Kidney	KMRC20	4.6
Kidney	KMRC2	4.5
Kidney	KMRC3	4.4
Kidney	OSRC2	5.7
Kidney	RCC10RGB	4.7
Kidney	SNU1272	4.3
Kidney	SNU349	4.6
Kidney	TUHR10TKB	4.6
Kidney	TUHR14TKB	4.6
Kidney	TUHR4TKB	4.4
Kidney	VMRCRCW	4.7
Kidney	VMRCRCZ	4.6
Large intestine	C2BBE1	5.9
Large intestine	CCK81	4.8
Large intestine	CL11	6.6
Large intestine	CL14	6.9
Large intestine	CL34	5.9
Large intestine	CL40	7.3
Large intestine	COLO205	5.4
Large intestine	COLO320	4.6
Large intestine	COLO678	6.6
Large intestine	CW2	5
Large intestine	DLD1	5
Large intestine	GP2D	6.4
Large intestine	HCC56	4.9
Large intestine	HCT116	5
Large intestine	HCT15	4.8
Large intestine	HS675T	6.8
Large intestine	HS698T	6.2
Large intestine	HT115	4.9
Large intestine	HT29	4.7
Large intestine	HT55	7
Large intestine	KM12	5.8
Large intestine	LOVO	6.6
Large intestine	LS1034	5.6
Large intestine	LS123	6.1
Large intestine	LS180	5.8
Large intestine	LS411N	5.6
Large intestine	LS513	7.2
Large intestine	MDST8	6.7
Large intestine	NCIH508	5.6
Large intestine	NCIH716	4.7
Large intestine	NCIH747	7.5
Large intestine	OUMS23	7.6
Large intestine	RCM1	7.7
Large intestine	RKO	4.9
Large intestine	SKCO1	6.4
Large intestine	SNU1040	5.1
Large intestine	SNU1197	7.2
Large intestine	SNU175	5
Large intestine	SNU283	5.1
Large intestine	SNU407	6.5
Large intestine	SNU503	7.1
Large intestine	SNU61	5
Large intestine	SNU81	6.5
Large intestine	SNUC1	7.5
Large intestine	SNUC2A	5.2
Large intestine	SNUC4	5.9
Large intestine	SNUC5	6.2
Large intestine	SW1116	5.7
Large intestine	SW1417	6.9
Large intestine	SW1463	6.3
Large intestine	SW403	5.6
Large intestine	SW480	7.1
Large intestine	SW48	7.2
Large intestine	SW620	6.8
Large intestine	SW837	6.6
Large intestine	SW948	5.8
Large intestine	T84	6
Liver	ALEXANDERCELLS	5.2
Liver	C3A	4.7
Liver	HEP3B217	4.8
Liver	HEPG2	4.5
Liver	HLE	5
Liver	HLF	5.1
Liver	HUH1	4.7
Liver	HUH6	7.4
Liver	HUH7	4.6
Liver	JHH1	4.8
Liver	JHH2	6.9
Liver	JHH4	4.8
Liver	JHH5	5.8
Liver	JHH6	5.2
Liver	JHH7	6.7
Liver	LI7	4.9
Liver	PLCPRF5	4.3
Liver	SKHEP1	8
Liver	SNU182	4.8
Liver	SNU387	6
Liver	SNU398	4.6
Liver	SNU423	4.4
Liver	SNU449	4.7
Liver	SNU475	6.6
Liver	SNU761	4.4
Liver	SNU878	5.9
Liver	SNU886	5.9
Lung	A549	6.4
Lung	ABC1	5.4
Lung	BEN	5.2
Lung	CAL12T	6
Lung	CALU1	6.1
Lung	CALU3	4.6
Lung	CALU6	4.5
Lung	CHAGOK1	5.4
Lung	COLO668	4.6
Lung	COLO699	4.6
Lung	CORL105	4.4
Lung	CORL23	6.8
Lung	CORL24	4.4
Lung	CORL279	4.3
Lung	CORL311	7.9
Lung	CORL47	5
Lung	CORL51	4.9
Lung	CORL88	4.9
Lung	CORL95	4.8
Lung	CPCN	4.9
Lung	DMS114	4.5
Lung	DMS153	5.2
Lung	DMS273	5.2
Lung	DMS454	4.6
Lung	DMS53	5.6
Lung	DMS79	4.8
Lung	DV90	7.7
Lung	EBC1	4.7
Lung	EPLC272H	5.8
Lung	HARA	5.2
Lung	HCC1171	5.3
Lung	HCC1195	7.6
Lung	HCC15	8.4
Lung	HCC2279	6.6
Lung	HCC2935	6.8
Lung	HCC33	4.4
Lung	HCC366	4.7
Lung	HCC4006	4.9
Lung	HCC44	5
Lung	HCC78	6.4
Lung	HCC827	5
Lung	HCC95	5.4
Lung	HLC1	9
Lung	HLFA	6.7
Lung	HS229T	6
Lung	HS618T	6.6
Lung	IALM	5
Lung	KNS62	4.9
Lung	LC1F	6.1
Lung	LC1SQSF	5.6
Lung	LCLC103H	4.5
Lung	LCLC97TM1	5.2
Lung	LK2	8.3
Lung	LOUNH91	6.2
Lung	LU65	5.1
Lung	LU99	4.8
Lung	LUDLU1	4.9
Lung	LXF289	6.2
Lung	MORCPR	6.7
Lung	NCIH1048	4.7
Lung	NCIH1092	4.4
Lung	NCIH1105	7
Lung	NCIH1155	4.6
Lung	NCIH1184	5.1
Lung	NCIH1299	4.9
Lung	NCIH1339	5.3
Lung	NCIH1341	4.5
Lung	NCIH1355	5.2
Lung	NCIH1373	5.1
Lung	NCIH1385	4.5
Lung	NCIH1395	4.9
Lung	NCIH1435	6.1
Lung	NCIH1436	6.5
Lung	NCIH1437	4.8
Lung	NCIH146	5
Lung	NCIH1563	5.5
Lung	NCIH1568	4.9
Lung	NCIH1573	4.8
Lung	NCIH1581	4.4
Lung	NCIH1618	4.6
Lung	NCIH1623	6.2
Lung	NCIH1648	6.6
Lung	NCIH1650	5.6
Lung	NCIH1651	8.3
Lung	NCIH1666	5.1
Lung	NCIH1693	5
Lung	NCIH1694	4.7
Lung	NCIH1703	6.3
Lung	NCIH1734	7.5
Lung	NCIH1755	5
Lung	NCIH1781	5
Lung	NCIH1792	6.1
Lung	NCIH1793	5.2
Lung	NCIH1836	6.3
Lung	NCIH1838	5.9
Lung	NCIH1869	6.6
Lung	NCIH1876	5.7
Lung	NCIH1915	4.7
Lung	NCIH1930	4.5
Lung	NCIH1944	5.2
Lung	NCIH1963	4.7
Lung	NCIH196	5.3
Lung	NCIH1975	5.1
Lung	NCIH2009	5.8
Lung	NCIH2023	5.5
Lung	NCIH2029	5.9
Lung	NCIH2030	6.1
Lung	NCIH2066	4.5
Lung	NCIH2081	4.9
Lung	NCIH2085	4.6
Lung	NCIH2087	5.2
Lung	NCIH209	4.5
Lung	NCIH2106	4.3
Lung	NCIH2110	5.1
Lung	NCIH211	4.9
Lung	NCIH2122	7.5
Lung	NCIH2126	4.6
Lung	NCIH2141	4.5
Lung	NCIH2170	5.6
Lung	NCIH2171	4.5
Lung	NCIH2172	5.8
Lung	NCIH2196	4.8
Lung	NCIH2227	4.7
Lung	NCIH2228	5.8
Lung	NCIH226	4.5
Lung	NCIH2286	4.8
Lung	NCIH2291	5.1
Lung	NCIH2342	6.3
Lung	NCIH2347	6.2
Lung	NCIH23	6.1
Lung	NCIH2405	5.4
Lung	NCIH2444	7.3
Lung	NCIH292	5.5
Lung	NCIH322	4.9
Lung	NCIH3255	5.4
Lung	NCIH358	5.9
Lung	NCIH441	5.2
Lung	NCIH446	4.7
Lung	NCIH460	5.2
Lung	NCIH510	5.2
Lung	NCIH520	7.3
Lung	NCIH522	6.1
Lung	NCIH524	4.4
Lung	NCIH526	4.7
Lung	NCIH596	6.4
Lung	NCIH647	5.8
Lung	NCIH650	4.9
Lung	NCIH661	6.8
Lung	NCIH69	4.4
Lung	NCIH727	4.6
Lung	NCIH810	4.7
Lung	NCIH82	5.4
Lung	NCIH838	4.6
Lung	NCIH841	5.7
Lung	NCIH854	4.5
Lung	NCIH889	6
Lung	PC14	4.9
Lung	RERFLCAD1	5.5
Lung	RERFLCAD2	6.2
Lung	RERFLCAI	4.7
Lung	RERFLCKJ	5.6
Lung	RERFLCMS	6.3
Lung	RERFLCSQ1	5.9
Lung	SBC5	4.9
Lung	SCLC21H	4.6
Lung	SHP77	5.2
Lung	SKLU1	8.1
Lung	SKMES1	4.4
Lung	SQ1	5
Lung	SW1271	5.4
Lung	SW1573	7.1
Lung	SW900	5.7
Lung	VMRCLCD	5.2
Lung	VMRCLCP	6.8
Oesophagus	COLO680N	4.9
Oesophagus	ECGI10	5.5
Oesophagus	KYSE140	8.1
Oesophagus	KYSE150	4.9
Oesophagus	KYSE180	5.7
Oesophagus	KYSE270	5.2
Oesophagus	KYSE30	6.4
Oesophagus	KYSE410	5.5
Oesophagus	KYSE450	6.7
Oesophagus	KYSE510	5.1
Oesophagus	KYSE520	5
Oesophagus	KYSE70	7.1
Oesophagus	OE19	5.8
Oesophagus	OE33	6.1
Oesophagus	TE10	5.4
Oesophagus	TE11	5.6
Oesophagus	TE14	6
Oesophagus	TE15	4.4
Oesophagus	TE1	5.4
Oesophagus	TE4	8.6
Oesophagus	TE5	4.9
Oesophagus	TE6	6.3
Oesophagus	TE8	4.4
Oesophagus	TE9	4.8
Oesophagus	TT	8.2
Ovary	59M	4.5
Ovary	A2780	4.6
Ovary	CAOV3	4.5
Ovary	CAOV4	4.6
Ovary	COLO704	8.7
Ovary	COV318	5
Ovary	COV362	4.6
Ovary	COV434	4.8
Ovary	COV504	4.7
Ovary	COV644	5.1
Ovary	EFO21	5.3
Ovary	EFO27	4.7
Ovary	ES2	5.3
Ovary	FUOV1	4.5
Ovary	HEYA8	6
Ovary	HS571T	5.2
Ovary	IGROV1	4.8
Ovary	JHOC5	4.5
Ovary	JHOM1	5.3
Ovary	JHOM2B	6.3
Ovary	JHOS2	4.8
Ovary	JHOS4	4.8
Ovary	KURAMOCHI	4.4
Ovary	MCAS	5.1
Ovary	NIHOVCAR3	4.7
Ovary	OAW28	4.3
Ovary	OAW42	4.9
Ovary	OC314	4.6
Ovary	OC316	4.4
Ovary	ONCODG1	4.7
Ovary	OV56	5.5
Ovary	OV7	4.3
Ovary	OV90	7.1
Ovary	OVCAR4	4.7
Ovary	OVCAR8	4.3
Ovary	OVISE	4.5
Ovary	OVK18	4.7
Ovary	OVKATE	4.8
Ovary	OVMANA	5.1
Ovary	OVSAHO	4.7
Ovary	OVTOKO	5
Ovary	RMGI	4.8
Ovary	RMUGS	5.3
Ovary	SKOV3	4.9
Ovary	SNU119	4.4
Ovary	SNU840	5.8
Ovary	SNU8	4.8
Ovary	TOV112D	5.1
Ovary	TOV21G	5.9
Ovary	TYKNU	5
Pancreas	ASPC1	6.3
Pancreas	BXPC3	5.3
Pancreas	CAPAN1	5.6
Pancreas	CAPAN2	7.1
Pancreas	CFPAC1	5.5
Pancreas	DANG	5.6
Pancreas	HPAC	6.3
Pancreas	HPAFII	7.2
Pancreas	HS766T	5.8
Pancreas	HUPT3	5.3
Pancreas	HUPT4	7.3
Pancreas	KCIMOH1	6.1
Pancreas	KLM1	4.5
Pancreas	KP2	6
Pancreas	KP3	4.7
Pancreas	KP4	5.5
Pancreas	L33	5.5
Pancreas	MIAPACA2	4.4
Pancreas	PANC0203	5.1
Pancreas	PANC0213	6.1
Pancreas	PANC0327	5.4
Pancreas	PANC0403	7
Pancreas	PANC0504	6
Pancreas	PANC0813	6.2
Pancreas	PANC1005	4.6
Pancreas	PANC1	5.1
Pancreas	PATU8902	4.7
Pancreas	PATU8988S	6.2
Pancreas	PATU8988T	4.5
Pancreas	PK1	4.5
Pancreas	PK45H	6.3
Pancreas	PK59	6.9
Pancreas	PL45	5.2
Pancreas	PSN1	4.9
Pancreas	QGP1	4.8
Pancreas	SNU213	6.1
Pancreas	SNU324	5.4
Pancreas	SNU410	4.7
Pancreas	SU8686	6
Pancreas	SUIT2	5.3
Pancreas	SW1990	5.3
Pancreas	T3M4	5.7
Pancreas	TCCPAN2	5.1
Pancreas	YAPC	4.6
Pleura	ACCMESO1	5.7
Pleura	DM3	5.9
Pleura	ISTMES1	4.4
Pleura	ISTMES2	4.4
Pleura	JL1	4.7
Pleura	MPP89	5.1
Pleura	MSTO211H	5.7
Pleura	NCIH2052	5.1
Pleura	NCIH2452	4.6
Pleura	NCIH28	5
Prostate	22RV1	4.6
Prostate	DU145	4.8
Prostate	LNCAPCLONEFGC	4.8
Prostate	MDAPCA2B	5.1
Prostate	NCIH660	4.3
Prostate	PC3	5.1
Prostate	VCAP	7.6
Salivary gland	A253	5.7
Salivary gland	YD15	4.6
Skin	A101D	5.9
Skin	A2058	6.1
Skin	A375	5
Skin	C32	5.3
Skin	CHL1	4.6
Skin	CJM	4.8
Skin	COLO679	4.7
Skin	COLO741	4.4
Skin	COLO783	4.9
Skin	COLO792	4.7
Skin	COLO800	4.5
Skin	COLO818	4.8
Skin	COLO829	4.9
Skin	COLO849	4.8
Skin	G361	4.6
Skin	GRM	4.6
Skin	HMCB	5.8
Skin	HS294T	6.6
Skin	HS600T	5.7
Skin	HS688AT	5.6
Skin	HS695T	7.2
Skin	HS839T	6.4
Skin	HS852T	5
Skin	HS895T	5.7
Skin	HS934T	5.6
Skin	HS936T	6.3
Skin	HS939T	6
Skin	HS940T	4.8
Skin	HS944T	5.1
Skin	HT144	4.6
Skin	IGR1	5.2
Skin	IGR37	4.5
Skin	IGR39	5.7
Skin	IPC298	4.7
Skin	K029AX	5.9
Skin	LOXIMVI	6.3
Skin	MALME3M	4.9
Skin	MDAMB435S	4.6
Skin	MELHO	5.1
Skin	MELJUSO	4.9
Skin	MEWO	4.8
Skin	RPMI7951	6.3
Skin	RVH421	5.1
Skin	SH4	4.6
Skin	SKMEL1	5.5
Skin	SKMEL24	5.1
Skin	SKMEL28	4.6
Skin	SKMEL2	4.5
Skin	SKMEL30	4.5
Skin	SKMEL31	6.1
Skin	SKMEL3	4.6
Skin	SKMEL5	4.7
Skin	UACC257	5.2
Skin	UACC62	4.8
Skin	WM115	5.5
Skin	WM1799	5.4
Skin	WM2664	4.5
Skin	WM793	7.1
Skin	WM88	5.5
Skin	WM983B	5
Small intestine	HUTU80	6.1
Soft tissue	A204	4.6
Soft tissue	G401	4.5
Soft tissue	G402	4.9
Soft tissue	GCT	5.5
Soft tissue	HS729	7.6
Soft tissue	HT1080	5.1
Soft tissue	KYM1	5
Soft tissue	MESSA	5.6
Soft tissue	RD	4.7
Soft tissue	RH30	4.3
Soft tissue	RH41	4.4
Soft tissue	RKN	6.8
Soft tissue	S117	5.3
Soft tissue	SJRH30	4.5
Soft tissue	SKLMS1	4.9
Soft tissue	SKUT1	4.9
Soft tissue	TE125T	5.3
Soft tissue	TE159T	4.7
Soft tissue	TE441T	6.3
Soft tissue	TE617T	4.6
Stomach	2313287	6.9
Stomach	AGS	6.2
Stomach	AZ521	4.9
Stomach	ECC10	7
Stomach	ECC12	4.6
Stomach	FU97	4.8
Stomach	GCIY	4.9
Stomach	GSS	5
Stomach	GSU	6
Stomach	HGC27	4.6
Stomach	HS746T	6.2
Stomach	HUG1N	5.2
Stomach	IM95	6.5
Stomach	KATOIII	7.5
Stomach	KE39	6.1
Stomach	LMSU	7.3
Stomach	MKN1	5.8
Stomach	MKN45	6.4
Stomach	MKN74	8.2
Stomach	MKN7	5
Stomach	NCCSTCK140	7.2
Stomach	NCIN87	6.8
Stomach	NUGC2	5.8
Stomach	NUGC3	5.6
Stomach	NUGC4	7.1
Stomach	OCUM1	7
Stomach	RERFGC1B	6.8
Stomach	SH10TC	4.7
Stomach	SNU16	4.7
Stomach	SNU1	5
Stomach	SNU216	6.8
Stomach	SNU520	7.2
Stomach	SNU5	4.9
Stomach	SNU601	6.5
Stomach	SNU620	5.1
Stomach	SNU668	6.3
Stomach	SNU719	8.3
Stomach	TGBC11TKB	7
Thyroid	8305C	5.2
Thyroid	8505C	4.5
Thyroid	BCPAP	7.8
Thyroid	BHT101	5.4
Thyroid	CAL62	4.7
Thyroid	CGTHW1	6.2
Thyroid	FTC133	5.6
Thyroid	FTC238	4.6
Thyroid	ML1	7.9
Thyroid	SW579	7
Thyroid	TT2609C02	5.3
Thyroid	TT	4.5
Upper aerodigestive tract	BHY	5.6
Upper aerodigestive tract	BICR16	5.5
Upper aerodigestive tract	BICR18	6.2
Upper aerodigestive tract	BICR22	7.9
Upper aerodigestive tract	BICR31	5.8
Upper aerodigestive tract	BICR56	8
Upper aerodigestive tract	BICR6	6
Upper aerodigestive tract	CAL27	6.3
Upper aerodigestive tract	CAL33	5.9
Upper aerodigestive tract	DETROIT562	5.6
Upper aerodigestive tract	FADU	4.5
Upper aerodigestive tract	HS840T	7.2
Upper aerodigestive tract	HSC2	4.8
Upper aerodigestive tract	HSC3	5.8
Upper aerodigestive tract	HSC4	4.8
Upper aerodigestive tract	PECAPJ15	6.2
Upper aerodigestive tract	PECAPJ34CLONEC12	6.2
Upper aerodigestive tract	PECAPJ41CLONED2	5.9
Upper aerodigestive tract	PECAPJ49	5.9
Upper aerodigestive tract	SCC15	6.4
Upper aerodigestive tract	SCC25	6.8
Upper aerodigestive tract	SCC4	4.8
Upper aerodigestive tract	SCC9	7.5
Upper aerodigestive tract	SNU1076	6.3
Upper aerodigestive tract	SNU1214	6.3
Upper aerodigestive tract	SNU46	4.8
Upper aerodigestive tract	SNU899	6
Upper aerodigestive tract	YD10B	4.8
Upper aerodigestive tract	YD38	5.5
Upper aerodigestive tract	YD8	5.6
Urinary tract	5637	8.9
Urinary tract	639V	5.3
Urinary tract	647V	4.7
Urinary tract	BC3C	5.4
Urinary tract	BFTC905	6.1
Urinary tract	CAL29	5.6
Urinary tract	HS172T	9.4
Urinary tract	HT1197	6.7
Urinary tract	HT1376	4.6
Urinary tract	J82	6.1
Urinary tract	JMSU1	7.4
Urinary tract	KMBC2	5.3
Urinary tract	KU1919	5.9
Urinary tract	RT11284	5.7
Urinary tract	RT112	5.2
Urinary tract	RT4	4.6
Urinary tract	SCABER	5.6
Urinary tract	SW1710	5
Urinary tract	SW780	6
Urinary tract	T24	4.7
Urinary tract	TCCSUP	6.6
Urinary tract	UMUC1	4.8
Urinary tract	UMUC3	6.4
Urinary tract	VMCUB1	5

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	7.4
Adrenal gland	3.1
Appendix	27.9
Bone marrow	13.1
Breast	8.3
Cerebral cortex	2.1
Cervix, uterine	12.3
Colon	15.2
Duodenum	9.7
Endometrium	30.1
Epididymis	1.5
Esophagus	61.3
Fallopian tube	9.8
Gallbladder	21
Heart muscle	1.2
Kidney	1.7
Liver	2.2
Lung	9.7
Lymph node	18.7
Ovary	6.3
Pancreas	0.4
Parathyroid gland	3.5
Placenta	7.6
Prostate	5.5
Rectum	20.3
Salivary gland	1.6
Seminal vesicle	3.6
Skeletal muscle	1.5
Skin	9.1
Small intestine	14.5
Smooth muscle	8.7
Spleen	17.5
Stomach	14.1
Testis	2.5
Thyroid gland	15.1
Tonsil	26.5
Urinary bladder	22.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27568520	loss of expression	Activated B-Cell-Like Diffuse Large B-Cell Lymphoma	BLIMP-1 expression was frequently associated with the ABC phenotype and plasmablastic morphologic subtype of DLBCL, yet 63% of the ABC-DLBCL patients were negative for BLIMP-1 protein expression.
26530011	underexpression	Diffuse Large B-Cell Lymphoma; Hodgkin Lymphoma	It has been shown in DLBCL and Hodgkin lymphoma that PRDM1 is downregulated by cellular microRNAs.
25991819	loss of expression	Central Nervous System Lymphoma	Several genes recurrently affected in PCNSL were common with systemic DLBCL, including loss of TNFAIP3, PRDM1, GNA13, TMEM30A, TBL1XR1, B2M, CD58, activating mutations of CD79B, CARD11, and translocations IgH-BCL6.
25533804	loss of expression	Lymphona	Genomic studies of ALCL-11 showed the TP53 loss and the in vivo subclonal expansion of lymphoma cells, lacking PRDM1/Blimp1 and carrying c-MYC gene amplification.
25203537	underexpression (copy number loss)	Nasal Type Extranodal NK/T-Cell Lymphoma	Of interest, this deleted region contains four candidate tumor suppressor genes whose decreased expression has been confirmed at the mRNA level: PRDM1, ATG5, AIM1, and HACE1.
23768641	underexpression (copy number loss); underexpresion (hypermethylation)	Nasal Type Extranodal NK/T-Cell Lymphoma	Frequent deletions and promoter methylations in PRDM1, ATG5, AIM1, FOXO3, HACE1 mapping to 6q21-q25, suggest their roles as potential tumor suppressors.
23348703	underexpression	Glioma	In this study, we showed that PRDM1 protein levels were inversely correlated with the pathological grade of gliomas and were predictive of patient survival in a retrospective analysis.
22723553	underexpression	Plasma Cell Myeloma	The expression of ASK1 and Blimp-1 showed an inverse correlation between normal human mature B cells and bone marrow plasma cells from patients with multiple myeloma (MM).
22711707	overexpression	Epstein-Barr Virus Positive HIV-Related Diffuse Large B-Cell Lymphoma	EBV+ tumor was associated with increased expression of BLIMP1 and CD30 and reduced expression of BCL6 and LMO2.
22580854	loss of expression	Epstein-Barr Virus-Related Lymphoma	The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
22102710	underexpression	Follicular Lymphoma	Gene expression analysis revealed increased expression of MAPK1, AKT1, PRKCE, IL4R and DROSHA and decreased expression of CDKN1A/p21, SOCS2, CHEK1, RAD51, KLF4, BLIMP1 and IRF4 in follicular lymphoma.
21615994	aberrant expression	Primary Gastrointestinal Diffuse Large B-Cell Lymphoma	The immunohistochemical findings were as follows: 100% positivity for CD20, 0% for CD3ε and CD5, 17.8% (16/90) for CD10, 75.6% (68/90) for bcl-6, 52.2% (47/90) for MUM-1 (cut off was 30%), 43.3% (39/90) for MUM-1 (cut off was 80%), 50.0% (45/90) for GCET1, 45.6% (41/90) for FOXP1, 23.3% (21/90) for LMO2, 42.2% (38/90) for bcl-2 and 8.9% (8/90) for BLIMP1.
21487109	loss of expression	Germinal Center-Derived B-Cell Lymphoma	Those were predominantly GCB-type DLBCL or follicular lymphoma grade 3, shared strong expression of IRF4/MUM1 and BCL6, and lacked PRDM1/BLIMP1 expression and t(14;18)/BCL2 breaks.
19433448	overexpression	Breast Carcinoma	Commensurately higher Blimp1/PRDM1 expression was detected in ERalpha-negative breast cancer cells and primary breast tumors.
17974277	aberrant expression	Squamous Cell Lung Carcinoma	Squamous cell carcinoma predominantly expressed PRDM1 protein ( P < 0.01).
17252022	underexpression	Waldenstrom Macroglobulinemia	We also found deregulation of genes involved in plasma cell differentiation such as PAX5, which was overexpressed in WM-PC, and IRF4 and BLIMP1, which were underexpressed.
16585013	aberrant expression	B-Cell Neoplasm	Most B-neoplastic cells showing plasmablastic differentiation were PRDM1-positive.
12453881	overexpression	Plasma Cell Myeloma	We observed the expression of Blimp-1 in the B-cell populations in all 11 MM patients but in none of 11 healthy subjects.
28675510	Underexpression	Colorectal Carcinoma	Ten TSGs were up-regulated (FAM123B, RB1, TP53, RUNX1, MSH2, BRCA1, BRCA2, SOX9, NPM1, and RNF43); six TSGs were down-regulated (PAX5, IZKF1, GATA3, PRDM1, TET2, and CYLD); four were associated with MSI tumors (MLH1, PTCH1, and CEBPA down-regulated and MSH6 up-regulated); and two were associated with MSS tumors (PHF6 and ASXL1 up-regulated).
28442738	Overexpression	Breast Carcinoma	Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients.
28378641	Underexpression	Lung Carcinoma	Here, we found that PRDM1 is expressed in normal human lung epithelium but is downregulated in lung cancer cells.

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.126	0.0116	45	47.5	7.4	Loss
BRCA	Breast invasive carcinoma	1075	0.102	0.00081	31.3	51.3	17.4	Neutral
CESC	Cervical and endocervical cancers	292	-0.108	0.0654	27.4	62.7	9.9	Neutral
COAD	Colon adenocarcinoma	449	-0.001	0.981	13.4	71.7	14.9	Neutral
ESCA	Esophageal carcinoma	183	0.117	0.114	27.3	57.4	15.3	Neutral
GBM	Glioblastoma multiforme	147	0.142	0.0853	31.3	65.3	3.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.073	0.0968	17.1	72.2	10.7	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.224	2.21e-07	26.5	71.8	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.028	0.635	9.7	88.2	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.136	0.0796	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.052	0.236	13.5	85.4	1.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.119	0.0229	34.3	52.7	12.9	Loss
LUAD	Lung adenocarcinoma	512	0.134	0.00237	50.4	42.6	7	Loss
LUSC	Lung squamous cell carcinoma	498	0.079	0.0793	25.7	55.2	19.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	-0.031	0.593	50	30	20	Loss
PAAD	Pancreatic adenocarcinoma	177	0.131	0.0829	46.3	51.4	2.3	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.107	0.176	11.7	84	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.108	0.0163	32.6	67	0.4	Neutral
READ	Rectum adenocarcinoma	164	0.077	0.324	16.5	62.8	20.7	Neutral
SARC	Sarcoma	255	0.076	0.227	27.5	53.3	19.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.37	2.21e-13	58	35.7	6.3	Loss
STAD	Stomach adenocarcinoma	413	0.067	0.174	18.9	64.4	16.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	-0.032	0.699	13.3	72	14.7	Neutral
THCA	Thyroid carcinoma	497	0.179	6.03e-05	1.4	98.4	0.2	Neutral
THYM	Thymoma	119	-0.215	0.0191	16.8	83.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.011	0.796	6.7	79.3	14	Neutral

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.114	0.0187	17	408	-0.001	0.964	NS/NA
BRCA	Breast invasive carcinoma	-0.139	3.82e-05	83	785	0.081	0.00352	NS/NA
CESC	Cervical and endocervical cancers	-0.06	0.289	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.071	0.211	19	297	0.001	0.0396	NS/NA
ESCA	Esophageal carcinoma	-0.171	0.0173	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.347	0.00483	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.061	0.154	20	522	-0.004	0.497	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.465	0	24	319	-0.104	3.48e-16	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.569	0	23	275	0.03	0.463	NS/NA
LAML	Acute Myeloid Leukemia	-0.281	0.000222	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.27	3.16e-10	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.133	0.00656	41	373	0.046	1.79e-24	NS/NA
LUAD	Lung adenocarcinoma	-0.098	0.0317	21	456	-0.001	0.716	NS/NA
LUSC	Lung squamous cell carcinoma	-0.089	0.0847	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.133	0.0722	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.358	5.81e-07	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.104	0.016	35	498	0.135	0.00573	NS/NA
READ	Rectum adenocarcinoma	-0.196	0.0491	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.143	0.02	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.409	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	0.002	0.976	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.786	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.179	2.17e-05	50	509	-0.074	4.34e-10	NS/NA
THYM	Thymoma	-0.708	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.058	0.215	34	431	-0.008	0.00256	NS/NA

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	2	Medium
Colon	0	Not detected
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	2	Medium
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	0	Not detected
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	0	Not detected
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	0	Not detected
Thyroid gland	0	Not detected
Tonsil	1	Low
Urinary bladder	0	Not detected
Vagina	2	Medium

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.265	NS	24476821
BRCA	Breast invasive carcinoma	521	1.01e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00017	Significant	22810696
GBM	Glioblastoma multiforme	157	2.52e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000163	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0306	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.56e-10	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00695	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000225	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	6.61e-25	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0107	Significant	26544944
READ	Rectum adenocarcinoma	67	0.054	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.237	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000125	Significant	25079317
THCA	Thyroid carcinoma	391	1.47e-11	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	5.45e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.12	0.605	NS
BRCA	Breast invasive carcinoma	1079	0.888	0.608	NS
CESC	Cervical and endocervical cancers	291	1.497	0.232	NS
COAD	Colon adenocarcinoma	439	0.834	0.556	NS
ESCA	Esophageal carcinoma	184	1.749	0.0842	NS
GBM	Glioblastoma multiforme	158	1.129	0.622	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.888	0.527	NS
KIRC	Kidney renal clear cell carcinoma	531	0.719	0.128	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.413	0.0361	Shorter
LAML	Acute Myeloid Leukemia	149	1.357	0.304	NS
LGG	Brain Lower Grade Glioma	511	1.879	0.0172	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.681	0.115	NS
LUAD	Lung adenocarcinoma	502	0.78	0.259	NS
LUSC	Lung squamous cell carcinoma	494	0.974	0.893	NS
OV	Ovarian serous cystadenocarcinoma	303	0.895	0.585	NS
PAAD	Pancreatic adenocarcinoma	177	1.722	0.0712	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.268	NS
PRAD	Prostate adenocarcinoma	497	0.632	0.612	NS
READ	Rectum adenocarcinoma	159	1.041	0.934	NS
SARC	Sarcoma	259	0.866	0.647	NS
SKCM	Skin Cutaneous Melanoma	459	0.469	0.00011	Longer
STAD	Stomach adenocarcinoma	388	1.088	0.723	NS
TGCT	Testicular Germ Cell Tumors	134	1.155	0.919	NS
THCA	Thyroid carcinoma	500	0.188	0.0183	Longer
THYM	Thymoma	119	1838800930.233	0.00949	Shorter
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.66	0.142	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.108	0.0299	Higher
BRCA	Breast invasive carcinoma	1071	0.024	0.433	NS
CESC	Cervical and endocervical cancers	167	-0.019	0.81	NS
COAD	Colon adenocarcinoma	445	-0.052	0.273	NS
ESCA	Esophageal carcinoma	162	0.008	0.919	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.068	0.15	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.037	0.396	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.021	0.741	NS
LIHC	Liver hepatocellular carcinoma	347	-0.07	0.193	NS
LUAD	Lung adenocarcinoma	507	-0.036	0.413	NS
LUSC	Lung squamous cell carcinoma	497	-0.03	0.502	NS
OV	Ovarian serous cystadenocarcinoma	302	0.004	0.95	NS
PAAD	Pancreatic adenocarcinoma	176	0.075	0.322	NS
READ	Rectum adenocarcinoma	156	0.012	0.885	NS
SKCM	Skin Cutaneous Melanoma	410	0.045	0.359	NS
STAD	Stomach adenocarcinoma	392	0.085	0.092	NS
TGCT	Testicular Germ Cell Tumors	81	-0.352	0.00129	Lower
THCA	Thyroid carcinoma	499	-0.045	0.318	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.049	0.271	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.104	0.0854	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.237	8.62e-08	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.063	0.152	NS
LGG	Brain Lower Grade Glioma	514	0.197	6.66e-06	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.071	0.173	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.078	0.182	NS
PAAD	Pancreatic adenocarcinoma	176	0.103	0.175	NS
STAD	Stomach adenocarcinoma	406	0.089	0.0726	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.199	3.54e-06	Lower

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PRDM1.

Summary
Symbol	PRDM1
Name	PR/SET domain 1
Aliases	PRDI-BF1; BLIMP1; B-lymphocyte-induced maturation protein 1; BLIMP-1; PRDI-binding factor-1; beta-interferon ......
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27568520	Activated B-Cell-Like Diffuse Large B-Cell Lymphoma	partner	Myc; p53	association	In these patients, loss of BLIMP-1 was associated with Myc overexpression and decreased expression of p53 pathway molecules.
26530011	Diffuse Large B-Cell Lymphoma; Hodgkin Lymphoma	upstream	EBV-miR-BHRF1-2	negative regulation	EBV-miR-BHRF1-2 inhibition upregulated PRDM1 protein expression in lymphoblastoid cell lines (LCL), supporting a role of miR-BHRF1-2 in PRDM1 downregulation in vivo.
26530011	Diffuse Large B-Cell Lymphoma; Hodgkin Lymphoma	downstream	SCARNA20	negative regulation	Inhibition of EBV-miR-BHRF1-2 negatively regulates cell cycle and decreases expression of SCARNA20, a small nucleolar RNA that is also downregulated by PRDM1 overexpression.
23348703	Glioma	upstream	miR-30a-5p	negative regulation	Using bioinformatics and biological approaches, we found that PRDM1 was a direct target of miR-30a-5p, and PRDM1 dysfunction was attributable to miR-30a-5p-mediated repression.
28442738	Breast Carcinoma	upstream	MAPK; miR-23b	Positive regulation; negative regulation	The present study, by using 2D and 3D breast cancer models, shows that the increased Blimp1 expression depends on both MAPK activation and miR-23b downmodulation.
28378641	Lung Carcinoma	downstream	Aiolos	Negative regulation	PRDM1 is silenced by an ectopically expressed lymphocyte-specific transcription factor Aiolos.
27687004	Plasmablastic Lymphoma	partner	MYC	coexpression	In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1α owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases.
27568520	Diffuse Large B-Cell Lymphoma	partner	Myc; p53	Positive correlation; negative correlation	In these patients, loss of BLIMP-1 was associated with Myc overexpression and decreased expression of p53 pathway molecules.