CR2Cancer

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

Function

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

Classification

Class	Modification	Substrate	Product	PubMed
DNA modification	DNA demethylation	mC	#	24335252

> Gene Ontology [ TOP ]
Biological Process	GO:0001701 in utero embryonic development GO:0001708 cell fate specification GO:0001824 blastocyst development GO:0001825 blastocyst formation GO:0001826 inner cell mass cell differentiation GO:0001827 inner cell mass cell fate commitment GO:0001894 tissue homeostasis GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006479 protein methylation GO:0007281 germ cell development GO:0007549 dosage compensation GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0008213 protein alkylation GO:0008543 fibroblast growth factor receptor signaling pathway GO:0009048 dosage compensation by inactivation of X chromosome GO:0009566 fertilization GO:0016570 histone modification GO:0016571 histone methylation GO:0018195 peptidyl-arginine modification GO:0018216 peptidyl-arginine methylation GO:0019827 stem cell population maintenance GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030718 germ-line stem cell population maintenance GO:0032259 methylation GO:0034969 histone arginine methylation GO:0034972 histone H3-R26 methylation GO:0035019 somatic stem cell population maintenance GO:0040029 regulation of gene expression, epigenetic GO:0040036 regulation of fibroblast growth factor receptor signaling pathway GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO:0043414 macromolecule methylation GO:0044030 regulation of DNA methylation GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044706 multi-multicellular organism process GO:0044728 DNA methylation or demethylation GO:0045165 cell fate commitment GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0051052 regulation of DNA metabolic process GO:0060249 anatomical structure homeostasis GO:0060817 inactivation of paternal X chromosome GO:0071774 response to fibroblast growth factor GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0098727 maintenance of cell number
Molecular Function	GO:0003682 chromatin binding GO:0008168 methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0031490 chromatin DNA binding GO:0043566 structure-specific DNA binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1266738: Developmental Biology R-HSA-452723: Transcriptional regulation of pluripotent stem cells

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1458053	c.1513C>T	p.R505C	Substitution - Missense	Skin
COSM3663861	c.613G>A	p.V205I	Substitution - Missense	Liver
COSM5444720	c.432T>C	p.C144C	Substitution - coding silent	Oesophagus
COSM1720117	c.1316G>A	p.R439Q	Substitution - Missense	Skin
COSM3699155	c.158T>G	p.F53C	Substitution - Missense	Large_intestine
COSM1720117	c.1316G>A	p.R439Q	Substitution - Missense	Skin
COSM2874526	c.833T>C	p.V278A	Substitution - Missense	Large_intestine
COSM1458059	c.543T>C	p.G181G	Substitution - coding silent	Large_intestine
COSM5623006	c.1366G>A	p.E456K	Substitution - Missense	Oesophagus
COSM486634	c.429T>C	p.C143C	Substitution - coding silent	Kidney
COSM1101400	c.336G>A	p.P112P	Substitution - coding silent	Central_nervous_system
COSM5554234	c.1408T>G	p.F470V	Substitution - Missense	Prostate
COSM1101398	c.622G>A	p.G208R	Substitution - Missense	Prostate
COSM4163050	c.730A>G	p.K244E	Substitution - Missense	Thyroid
COSM4959021	c.200C>T	p.P67L	Substitution - Missense	Liver
COSM2874501	c.1662C>A	p.I554I	Substitution - coding silent	Large_intestine
COSM486635	c.13C>T	p.R5W	Substitution - Missense	Kidney
COSM3765411	c.910G>A	p.E304K	Substitution - Missense	Central_nervous_system
COSM4978937	c.813T>C	p.S271S	Substitution - coding silent	Oesophagus
COSM1101395	c.751G>T	p.E251*	Substitution - Nonsense	Endometrium
COSM1458056	c.1274T>C	p.V425A	Substitution - Missense	Large_intestine
COSM3901325	c.889G>A	p.G297R	Substitution - Missense	Skin
COSM5409822	c.1229C>T	p.T410I	Substitution - Missense	Skin
COSM486632	c.1183+1G>T	p.?	Unknown	Kidney
COSM5749826	c.496A>G	p.T166A	Substitution - Missense	Genital_tract
COSM5562420	c.1267C>T	p.P423S	Substitution - Missense	Prostate
COSM1101398	c.622G>A	p.G208R	Substitution - Missense	Endometrium
COSM1472097	c.335C>T	p.P112L	Substitution - Missense	Urinary_tract
COSM2874534	c.594G>A	p.T198T	Substitution - coding silent	Skin
COSM3650665	c.1540G>A	p.E514K	Substitution - Missense	Skin
COSM1221875	c.659A>G	p.H220R	Substitution - Missense	Large_intestine
COSM3650666	c.1290G>A	p.R430R	Substitution - coding silent	Skin
COSM3901325	c.889G>A	p.G297R	Substitution - Missense	Stomach
COSM5677961	c.198G>A	p.M66I	Substitution - Missense	Soft_tissue
COSM338085	c.989G>C	p.C330S	Substitution - Missense	Lung
COSM3901327	c.350G>A	p.S117N	Substitution - Missense	Stomach
COSM3650675	c.612C>T	p.F204F	Substitution - coding silent	Skin
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM125563	c.518C>T	p.S173L	Substitution - Missense	Upper_aerodigestive_tract
COSM3901322	c.1331G>A	p.R444Q	Substitution - Missense	Stomach
COSM3929619	c.1155G>A	p.P385P	Substitution - coding silent	Central_nervous_system
COSM1239926	c.1376G>A	p.R459Q	Substitution - Missense	Oesophagus
COSM4519364	c.1006G>A	p.E336K	Substitution - Missense	Skin
COSM3925534	c.475C>T	p.L159L	Substitution - coding silent	Skin
COSM4462102	c.1233C>A	p.Y411*	Substitution - Nonsense	Skin
COSM4717476	c.423C>T	p.G141G	Substitution - coding silent	Large_intestine
COSM3901329	c.281G>A	p.W94*	Substitution - Nonsense	Skin
COSM4483169	c.267C>T	p.L89L	Substitution - coding silent	Skin
COSM5800111	c.700+7G>A	p.?	Unknown	Breast
COSM3901329	c.281G>A	p.W94*	Substitution - Nonsense	Stomach
COSM5749433	c.913-2A>T	p.?	Unknown	Genital_tract
COSM5805838	c.17C>A	p.P6Q	Substitution - Missense	Liver
COSM4163049	c.1629T>C	p.D543D	Substitution - coding silent	Thyroid
COSM5778306	c.1418C>T	p.S473F	Substitution - Missense	Breast
COSM4909710	c.426G>A	p.P142P	Substitution - coding silent	Liver
COSM486633	c.620A>G	p.Y207C	Substitution - Missense	Kidney
COSM3786029	c.1184-4A>G	p.?	Unknown	Pancreas
COSM4717474	c.1285G>A	p.D429N	Substitution - Missense	Large_intestine
COSM5567507	c.501C>T	p.S167S	Substitution - coding silent	Prostate
COSM3983766	c.1355T>G	p.L452R	Substitution - Missense	Oesophagus
COSM4608019	c.823G>T	p.A275S	Substitution - Missense	Adrenal_gland
COSM454810	c.616C>T	p.L206L	Substitution - coding silent	Breast
COSM4757129	c.965G>T	p.G322V	Substitution - Missense	Stomach
COSM1673963	c.1081G>A	p.E361K	Substitution - Missense	Skin
COSM6007451	c.773C>T	p.T258M	Substitution - Missense	Prostate
COSM3650667	c.1211G>A	p.R404K	Substitution - Missense	Skin
COSM3901323	c.1308C>T	p.L436L	Substitution - coding silent	Stomach
COSM454811	c.600G>A	p.E200E	Substitution - coding silent	Breast
COSM1221877	c.1553A>C	p.K518T	Substitution - Missense	Large_intestine
COSM4772368	c.869C>T	p.A290V	Substitution - Missense	Stomach
COSM1101396	c.710C>A	p.S237Y	Substitution - Missense	Endometrium
COSM5806987	c.363C>G	p.Y121*	Substitution - Nonsense	Liver
COSM1101388	c.1704T>C	p.H568H	Substitution - coding silent	Endometrium
COSM82307	c.1419T>C	p.S473S	Substitution - coding silent	Ovary
COSM1221876	c.995G>A	p.R332H	Substitution - Missense	Large_intestine
COSM1101389	c.1342C>T	p.R448W	Substitution - Missense	Endometrium
COSM4717475	c.823G>A	p.A275T	Substitution - Missense	Stomach
COSM5919616	c.1130C>T	p.P377L	Substitution - Missense	Skin
COSM3951830	c.134C>G	p.T45S	Substitution - Missense	Lung
COSM195396	c.1514G>A	p.R505H	Substitution - Missense	Large_intestine
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM3650669	c.1183G>T	p.E395*	Substitution - Nonsense	Skin
COSM5688249	c.1267C>G	p.P423A	Substitution - Missense	Soft_tissue
COSM3650673	c.822C>T	p.I274I	Substitution - coding silent	Skin
COSM750812	c.750A>G	p.P250P	Substitution - coding silent	Lung
COSM3650674	c.666G>A	p.A222A	Substitution - coding silent	Skin
COSM5345627	c.1598A>C	p.D533A	Substitution - Missense	Large_intestine
COSM2874502	c.1626_1628delGGA	p.E542delE	Deletion - In frame	Large_intestine
COSM4529948	c.1656G>A	p.G552G	Substitution - coding silent	Skin
COSM4440169	c.689delC	p.P230fs*64	Deletion - Frameshift	Thyroid
COSM134250	c.1610G>A	p.R537Q	Substitution - Missense	Skin
COSM1744170	c.221C>T	p.A74V	Substitution - Missense	Biliary_tract
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM3951827	c.928C>G	p.H310D	Substitution - Missense	Lung
COSM1700236	c.736T>G	p.S246A	Substitution - Missense	Skin
COSM3650670	c.1116A>T	p.K372N	Substitution - Missense	Skin
COSM5758979	c.1557C>A	p.C519*	Substitution - Nonsense	Bone
COSM3901324	c.1237T>C	p.Y413H	Substitution - Missense	Stomach
COSM750810	c.216G>T	p.R72R	Substitution - coding silent	Lung
COSM4539678	c.271G>A	p.D91N	Substitution - Missense	Skin
COSM1458053	c.1513C>T	p.R505C	Substitution - Missense	Large_intestine
COSM5434483	c.182C>T	p.S61F	Substitution - Missense	Oesophagus
COSM393841	c.800G>T	p.G267V	Substitution - Missense	Lung
COSM4959021	c.200C>T	p.P67L	Substitution - Missense	Liver
COSM3901331	c.101C>T	p.P34L	Substitution - Missense	Stomach
COSM72280	c.982G>A	p.V328I	Substitution - Missense	Ovary
COSM1173421	c.1351A>G	p.I451V	Substitution - Missense	Oesophagus
COSM1158181	c.1247A>C	p.D416A	Substitution - Missense	Pancreas
COSM1569565	c.54G>A	p.P18P	Substitution - coding silent	Large_intestine
COSM422069	c.598G>C	p.E200Q	Substitution - Missense	Urinary_tract
COSM1101400	c.336G>A	p.P112P	Substitution - coding silent	Endometrium
COSM195396	c.1514G>A	p.R505H	Substitution - Missense	Endometrium
COSM3925535	c.20G>A	p.S7N	Substitution - Missense	Skin
COSM1101392	c.1119T>G	p.F373L	Substitution - Missense	Endometrium
COSM454809	c.888C>T	p.Y296Y	Substitution - coding silent	Prostate
COSM2874509	c.1548C>T	p.P516P	Substitution - coding silent	Large_intestine
COSM3763391	c.1416A>G	p.Q472Q	Substitution - coding silent	Large_intestine
COSM5626323	c.56C>T	p.P19L	Substitution - Missense	Oesophagus
COSM454809	c.888C>T	p.Y296Y	Substitution - coding silent	Prostate
COSM3650675	c.612C>T	p.F204F	Substitution - coding silent	Skin
COSM3650678	c.567G>A	p.G189G	Substitution - coding silent	Skin
COSM2874534	c.594G>A	p.T198T	Substitution - coding silent	Skin
COSM2874542	c.438T>C	p.P146P	Substitution - coding silent	Large_intestine
COSM4610123	c.544C>T	p.P182S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3996116	c.131C>A	p.A44D	Substitution - Missense	Kidney
COSM3650674	c.666G>A	p.A222A	Substitution - coding silent	Skin
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM3834972	c.704C>T	p.S235F	Substitution - Missense	Breast
COSM5697624	c.1091T>C	p.V364A	Substitution - Missense	Soft_tissue
COSM5492394	c.14G>A	p.R5Q	Substitution - Missense	Biliary_tract
COSM454808	c.1184-1_1184insC	p.E395fs*9	Unknown	Breast
COSM3650673	c.822C>T	p.I274I	Substitution - coding silent	Skin
COSM1635853	c.1593C>T	p.A531A	Substitution - coding silent	Liver
COSM3413103	c.792A>G	p.P264P	Substitution - coding silent	Central_nervous_system
COSM3786028	c.1257C>T	p.L419L	Substitution - coding silent	Pancreas
COSM4717475	c.823G>A	p.A275T	Substitution - Missense	Large_intestine
COSM2874515	c.1308_1309delCT	p.C437fs*5	Deletion - Frameshift	Large_intestine
COSM1314177	c.1129C>T	p.P377S	Substitution - Missense	Urinary_tract
COSM3901326	c.871A>G	p.S291G	Substitution - Missense	Stomach
COSM6013183	c.1458C>G	p.D486E	Substitution - Missense	Skin
COSM5679243	c.455C>A	p.P152Q	Substitution - Missense	Soft_tissue
COSM3925534	c.475C>T	p.L159L	Substitution - coding silent	Skin
COSM2874522	c.939C>T	p.H313H	Substitution - coding silent	Large_intestine
COSM3650680	c.60G>A	p.E20E	Substitution - coding silent	Skin
COSM3951828	c.328G>A	p.E110K	Substitution - Missense	Lung
COSM381655	c.1058G>T	p.C353F	Substitution - Missense	Lung
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM3663861	c.613G>A	p.V205I	Substitution - Missense	Liver
COSM1569568	c.1650C>A	p.I550I	Substitution - coding silent	Large_intestine
COSM1569567	c.1233C>T	p.Y411Y	Substitution - coding silent	Large_intestine
COSM1458060	c.404G>A	p.G135D	Substitution - Missense	Large_intestine
COSM3650673	c.822C>T	p.I274I	Substitution - coding silent	Stomach
COSM3650675	c.612C>T	p.F204F	Substitution - coding silent	Skin
COSM1221875	c.659A>G	p.H220R	Substitution - Missense	Oesophagus
COSM5561414	c.334C>T	p.P112S	Substitution - Missense	Prostate
COSM1101393	c.1083G>T	p.E361D	Substitution - Missense	Endometrium
COSM81613	c.1134G>T	p.V378V	Substitution - coding silent	Ovary
COSM4980204	c.325A>T	p.R109W	Substitution - Missense	Oesophagus
COSM454809	c.888C>T	p.Y296Y	Substitution - coding silent	Prostate
COSM1262947	c.505T>G	p.L169V	Substitution - Missense	Stomach
COSM3925533	c.608A>C	p.H203P	Substitution - Missense	Skin
COSM227788	c.1297C>T	p.P433S	Substitution - Missense	Skin
COSM3901328	c.333G>T	p.V111V	Substitution - coding silent	Stomach
COSM4387923	c.1679C>T	p.T560I	Substitution - Missense	Pancreas
COSM1458057	c.1223T>C	p.V408A	Substitution - Missense	Large_intestine
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM3951825	c.1365T>G	p.H455Q	Substitution - Missense	Lung
COSM3650672	c.874G>A	p.E292K	Substitution - Missense	Skin
COSM3650668	c.1186T>G	p.S396A	Substitution - Missense	Skin
COSM72280	c.982G>A	p.V328I	Substitution - Missense	Bone
COSM3650677	c.591C>T	p.F197F	Substitution - coding silent	Skin
COSM3901330	c.276G>T	p.L92L	Substitution - coding silent	Stomach
COSM3723185	c.958G>A	p.G320S	Substitution - Missense	Upper_aerodigestive_tract
COSM241240	c.1586A>G	p.H529R	Substitution - Missense	Prostate
COSM1221878	c.795T>G	p.H265Q	Substitution - Missense	Large_intestine
COSM2874517	c.1250A>C	p.K417T	Substitution - Missense	Large_intestine
COSM3925532	c.1156G>A	p.G386R	Substitution - Missense	Skin
COSM314407	c.1005G>T	p.K335N	Substitution - Missense	Lung
COSM1101397	c.631C>A	p.P211T	Substitution - Missense	Endometrium
COSM1472098	c.957A>G	p.G319G	Substitution - coding silent	Prostate
COSM1101391	c.1202G>T	p.R401I	Substitution - Missense	Endometrium
COSM1552808	c.1574C>G	p.S525C	Substitution - Missense	Cervix
COSM1472097	c.335C>T	p.P112L	Substitution - Missense	Prostate
COSM3650679	c.315C>T	p.P105P	Substitution - coding silent	Skin
COSM4553690	c.598G>A	p.E200K	Substitution - Missense	Skin
COSM1158181	c.1247A>C	p.D416A	Substitution - Missense	Pancreas
COSM3951829	c.147C>A	p.D49E	Substitution - Missense	Lung
COSM1165381	c.1315C>T	p.R439*	Substitution - Nonsense	Large_intestine
COSM1101389	c.1342C>T	p.R448W	Substitution - Missense	Skin
COSM750811	c.655C>T	p.L219L	Substitution - coding silent	Lung
COSM4476800	c.209C>T	p.P70L	Substitution - Missense	Skin
COSM1101387	c.1710C>G	p.D570E	Substitution - Missense	Endometrium
COSM1489405	c.593C>T	p.T198M	Substitution - Missense	Breast
COSM195396	c.1514G>A	p.R505H	Substitution - Missense	Large_intestine
COSM3951826	c.1335C>A	p.D445E	Substitution - Missense	Lung
COSM3650674	c.666G>A	p.A222A	Substitution - coding silent	Breast
COSM3942735	c.1027C>T	p.Q343*	Substitution - Nonsense	Oesophagus
COSM5040490	c.1042A>T	p.I348L	Substitution - Missense	Liver
COSM3413102	c.1565G>T	p.C522F	Substitution - Missense	Central_nervous_system
COSM5912837	c.595G>A	p.E199K	Substitution - Missense	Skin
COSM3650671	c.925G>A	p.G309S	Substitution - Missense	Skin
COSM377741	c.1435C>G	p.H479D	Substitution - Missense	Lung
COSM1720117	c.1316G>A	p.R439Q	Substitution - Missense	Skin
COSM5409824	c.459C>T	p.P153P	Substitution - coding silent	Skin
COSM2874534	c.594G>A	p.T198T	Substitution - coding silent	Oesophagus
COSM373856	c.635G>T	p.S212I	Substitution - Missense	Lung
COSM4529948	c.1656G>A	p.G552G	Substitution - coding silent	Skin
COSM1458053	c.1513C>T	p.R505C	Substitution - Missense	Skin
COSM1101394	c.1038G>A	p.G346G	Substitution - coding silent	Endometrium
COSM3763392	c.963G>A	p.T321T	Substitution - coding silent	Large_intestine
COSM4591210	c.187G>C	p.A63P	Substitution - Missense	Upper_aerodigestive_tract
COSM5634215	c.539_540insG	p.D180fs*57	Insertion - Frameshift	Oesophagus
COSM1458062	c.27C>T	p.A9A	Substitution - coding silent	Large_intestine
COSM3650676	c.601G>T	p.D201Y	Substitution - Missense	Skin
COSM1101401	c.287G>T	p.S96I	Substitution - Missense	Endometrium
COSM1101399	c.365C>T	p.A122V	Substitution - Missense	Endometrium
COSM5409823	c.938A>G	p.H313R	Substitution - Missense	Skin
COSM1101390	c.1221G>T	p.K407N	Substitution - Missense	Endometrium
COSM1314176	c.1337G>A	p.R446Q	Substitution - Missense	Urinary_tract
COSM5429677	c.1573T>C	p.S525P	Substitution - Missense	Oesophagus
COSM2874511	c.1505G>A	p.S502N	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for PRDM14.

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.133	NA	NA	NA

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	5.1
Autonomic ganglia	CHP212	5
Autonomic ganglia	IMR32	4.8
Autonomic ganglia	KELLY	4.8
Autonomic ganglia	KPNRTBM1	5.1
Autonomic ganglia	KPNSI9S	5
Autonomic ganglia	KPNYN	5.3
Autonomic ganglia	MHHNB11	5.6
Autonomic ganglia	NB1	5.1
Autonomic ganglia	NH6	5.2
Autonomic ganglia	SHSY5Y	4.7
Autonomic ganglia	SIMA	5.3
Autonomic ganglia	SKNAS	5.9
Autonomic ganglia	SKNBE2	5
Autonomic ganglia	SKNDZ	4.9
Autonomic ganglia	SKNFI	5.2
Autonomic ganglia	SKNSH	5.1
Biliary tract	HUCCT1	5.5
Biliary tract	HUH28	5.3
Biliary tract	SNU1079	5.4
Biliary tract	SNU1196	5.3
Biliary tract	SNU245	5.4
Biliary tract	SNU308	5
Biliary tract	SNU478	5.7
Bone	143B	4.6
Bone	A673	5.2
Bone	CADOES1	4.9
Bone	CAL78	4.7
Bone	G292CLONEA141B1	5
Bone	HOS	5.1
Bone	HS706T	4.5
Bone	HS737T	4.7
Bone	HS819T	4.7
Bone	HS821T	4.8
Bone	HS822T	4.6
Bone	HS863T	5
Bone	HS870T	4.7
Bone	HS888T	4.7
Bone	MG63	4.8
Bone	MHHES1	4.8
Bone	OUMS27	4.8
Bone	RDES	5
Bone	SJSA1	5
Bone	SKES1	5.2
Bone	SKNMC	4.9
Bone	SW1353	4.8
Bone	T173	5.3
Bone	TC71	5.3
Bone	U2OS	4.8
Breast	AU565	5.1
Breast	BT20	5.1
Breast	BT474	4.6
Breast	BT483	5.3
Breast	BT549	5.4
Breast	CAL120	4.9
Breast	CAL148	4.9
Breast	CAL51	4.9
Breast	CAL851	4.9
Breast	CAMA1	4.8
Breast	DU4475	5.4
Breast	EFM192A	4.9
Breast	EFM19	5.3
Breast	EVSAT	4.8
Breast	HCC1143	5
Breast	HCC1187	5
Breast	HCC1395	4.9
Breast	HCC1419	4.7
Breast	HCC1428	5.1
Breast	HCC1500	5
Breast	HCC1569	5.3
Breast	HCC1599	4.8
Breast	HCC1806	4.6
Breast	HCC1937	4.7
Breast	HCC1954	5.1
Breast	HCC202	4.8
Breast	HCC2157	5
Breast	HCC2218	5.7
Breast	HCC38	4.6
Breast	HCC70	5.2
Breast	HDQP1	5
Breast	HMC18	5
Breast	HS274T	4.7
Breast	HS281T	4.5
Breast	HS343T	5
Breast	HS578T	4.9
Breast	HS606T	4.8
Breast	HS739T	4.6
Breast	HS742T	4.8
Breast	JIMT1	5.3
Breast	KPL1	4.9
Breast	MCF7	4.8
Breast	MDAMB134VI	4.9
Breast	MDAMB157	5
Breast	MDAMB175VII	4.9
Breast	MDAMB231	5.2
Breast	MDAMB361	4.8
Breast	MDAMB415	4.9
Breast	MDAMB436	4.5
Breast	MDAMB453	5.1
Breast	MDAMB468	5.1
Breast	SKBR3	5
Breast	T47D	4.9
Breast	UACC812	5
Breast	UACC893	4.9
Breast	YMB1	5.2
Breast	ZR751	4.5
Breast	ZR7530	4.7
Central nervous system	1321N1	4.7
Central nervous system	42MGBA	4.8
Central nervous system	8MGBA	4.7
Central nervous system	A172	4.7
Central nervous system	AM38	4.7
Central nervous system	BECKER	4.8
Central nervous system	CAS1	4.9
Central nervous system	CCFSTTG1	4.6
Central nervous system	D283MED	4.9
Central nervous system	D341MED	4.9
Central nervous system	DAOY	4.9
Central nervous system	DBTRG05MG	4.7
Central nervous system	DKMG	4.6
Central nervous system	GAMG	4.9
Central nervous system	GB1	4.8
Central nervous system	GI1	5.2
Central nervous system	GMS10	4.8
Central nervous system	GOS3	5.5
Central nervous system	H4	5
Central nervous system	HS683	5
Central nervous system	KALS1	4.9
Central nervous system	KG1C	4.9
Central nervous system	KNS42	5.1
Central nervous system	KNS60	4.7
Central nervous system	KNS81	5
Central nervous system	KS1	4.5
Central nervous system	LN18	5.1
Central nervous system	LN229	5
Central nervous system	M059K	4.6
Central nervous system	MOGGCCM	5.2
Central nervous system	MOGGUVW	4.9
Central nervous system	NMCG1	4.4
Central nervous system	ONS76	5.2
Central nervous system	SF126	5.3
Central nervous system	SF295	4.8
Central nervous system	SNB19	4.9
Central nervous system	SNU1105	5.1
Central nervous system	SNU201	4.9
Central nervous system	SNU466	5.4
Central nervous system	SNU489	4.4
Central nervous system	SNU626	5
Central nervous system	SNU738	5.3
Central nervous system	SW1088	4.9
Central nervous system	SW1783	4.9
Central nervous system	T98G	4.9
Central nervous system	TM31	4.5
Central nervous system	U118MG	4.6
Central nervous system	U138MG	4.8
Central nervous system	U251MG	4.9
Central nervous system	U87MG	4.8
Central nervous system	YH13	4.6
Central nervous system	YKG1	4.4
Endometrium	AN3CA	5.6
Endometrium	COLO684	5.2
Endometrium	EFE184	5.2
Endometrium	EN	5.1
Endometrium	ESS1	4.7
Endometrium	HEC108	5.4
Endometrium	HEC151	5.2
Endometrium	HEC1A	5
Endometrium	HEC1B	5.1
Endometrium	HEC251	5
Endometrium	HEC265	5.4
Endometrium	HEC50B	5.4
Endometrium	HEC59	4.9
Endometrium	HEC6	4.9
Endometrium	ISHIKAWAHERAKLIO02ER	5
Endometrium	JHUEM1	5.1
Endometrium	JHUEM2	5
Endometrium	JHUEM3	4.8
Endometrium	KLE	5.3
Endometrium	MFE280	5.8
Endometrium	MFE296	4.7
Endometrium	MFE319	5.4
Endometrium	RL952	5
Endometrium	SNGM	5.1
Endometrium	SNU1077	4.9
Endometrium	SNU685	5
Endometrium	TEN	5.3
Haematopoietic and lymphoid	697	5
Haematopoietic and lymphoid	A3KAW	5.4
Haematopoietic and lymphoid	A4FUK	5.3
Haematopoietic and lymphoid	ALLSIL	5.6
Haematopoietic and lymphoid	AML193	4.9
Haematopoietic and lymphoid	AMO1	5.2
Haematopoietic and lymphoid	BCP1	4.9
Haematopoietic and lymphoid	BDCM	5.5
Haematopoietic and lymphoid	BL41	5.1
Haematopoietic and lymphoid	BL70	5.3
Haematopoietic and lymphoid	BV173	5
Haematopoietic and lymphoid	CA46	5.1
Haematopoietic and lymphoid	CI1	5.3
Haematopoietic and lymphoid	CMK115	4.9
Haematopoietic and lymphoid	CMK86	5
Haematopoietic and lymphoid	CMK	5
Haematopoietic and lymphoid	CMLT1	4.7
Haematopoietic and lymphoid	COLO775	4.9
Haematopoietic and lymphoid	DAUDI	5.2
Haematopoietic and lymphoid	DB	5
Haematopoietic and lymphoid	DEL	5.4
Haematopoietic and lymphoid	DND41	4.8
Haematopoietic and lymphoid	DOHH2	5.5
Haematopoietic and lymphoid	EB1	5.7
Haematopoietic and lymphoid	EB2	5.6
Haematopoietic and lymphoid	EHEB	5.1
Haematopoietic and lymphoid	EJM	5.4
Haematopoietic and lymphoid	EM2	4.9
Haematopoietic and lymphoid	EOL1	4.7
Haematopoietic and lymphoid	F36P	4.7
Haematopoietic and lymphoid	GA10	5.3
Haematopoietic and lymphoid	GDM1	5.1
Haematopoietic and lymphoid	GRANTA519	5.3
Haematopoietic and lymphoid	HDLM2	5.1
Haematopoietic and lymphoid	HDMYZ	4.8
Haematopoietic and lymphoid	HEL9217	4.6
Haematopoietic and lymphoid	HEL	4.7
Haematopoietic and lymphoid	HH	5.2
Haematopoietic and lymphoid	HL60	5.1
Haematopoietic and lymphoid	HPBALL	5.1
Haematopoietic and lymphoid	HS604T	5.4
Haematopoietic and lymphoid	HS611T	5.2
Haematopoietic and lymphoid	HS616T	4.9
Haematopoietic and lymphoid	HS751T	5.1
Haematopoietic and lymphoid	HT	5.5
Haematopoietic and lymphoid	HTK	5
Haematopoietic and lymphoid	HUNS1	5.2
Haematopoietic and lymphoid	HUT102	4.8
Haematopoietic and lymphoid	HUT78	5.1
Haematopoietic and lymphoid	JEKO1	5.2
Haematopoietic and lymphoid	JK1	5.4
Haematopoietic and lymphoid	JM1	5.7
Haematopoietic and lymphoid	JURKAT	4.9
Haematopoietic and lymphoid	JURLMK1	5.2
Haematopoietic and lymphoid	JVM2	4.7
Haematopoietic and lymphoid	JVM3	5
Haematopoietic and lymphoid	K562	5
Haematopoietic and lymphoid	KARPAS299	5.1
Haematopoietic and lymphoid	KARPAS422	5.1
Haematopoietic and lymphoid	KARPAS620	5.2
Haematopoietic and lymphoid	KASUMI1	4.6
Haematopoietic and lymphoid	KASUMI2	5.4
Haematopoietic and lymphoid	KASUMI6	4.8
Haematopoietic and lymphoid	KCL22	5
Haematopoietic and lymphoid	KE37	4.8
Haematopoietic and lymphoid	KE97	5.3
Haematopoietic and lymphoid	KG1	5.6
Haematopoietic and lymphoid	KHM1B	5.3
Haematopoietic and lymphoid	KIJK	5.1
Haematopoietic and lymphoid	KMH2	5.3
Haematopoietic and lymphoid	KMM1	5.7
Haematopoietic and lymphoid	KMS11	5.5
Haematopoietic and lymphoid	KMS12BM	5.5
Haematopoietic and lymphoid	KMS18	4.6
Haematopoietic and lymphoid	KMS20	5.1
Haematopoietic and lymphoid	KMS21BM	4.5
Haematopoietic and lymphoid	KMS26	5.5
Haematopoietic and lymphoid	KMS27	5.2
Haematopoietic and lymphoid	KMS28BM	5.2
Haematopoietic and lymphoid	KMS34	5.9
Haematopoietic and lymphoid	KO52	4.7
Haematopoietic and lymphoid	KOPN8	5.2
Haematopoietic and lymphoid	KU812	5
Haematopoietic and lymphoid	KYO1	5.5
Haematopoietic and lymphoid	L1236	5.3
Haematopoietic and lymphoid	L363	5.3
Haematopoietic and lymphoid	L428	5.1
Haematopoietic and lymphoid	L540	5.5
Haematopoietic and lymphoid	LAMA84	4.9
Haematopoietic and lymphoid	LOUCY	4.8
Haematopoietic and lymphoid	LP1	5.6
Haematopoietic and lymphoid	M07E	4.5
Haematopoietic and lymphoid	MC116	5.5
Haematopoietic and lymphoid	ME1	5.2
Haematopoietic and lymphoid	MEC1	5
Haematopoietic and lymphoid	MEC2	5.1
Haematopoietic and lymphoid	MEG01	4.9
Haematopoietic and lymphoid	MHHCALL2	4.8
Haematopoietic and lymphoid	MHHCALL3	5
Haematopoietic and lymphoid	MHHCALL4	5.4
Haematopoietic and lymphoid	MINO	5.1
Haematopoietic and lymphoid	MJ	4.9
Haematopoietic and lymphoid	MM1S	5.7
Haematopoietic and lymphoid	MOLM13	5.3
Haematopoietic and lymphoid	MOLM16	4.7
Haematopoietic and lymphoid	MOLM6	4.9
Haematopoietic and lymphoid	MOLP2	5.3
Haematopoietic and lymphoid	MOLP8	5.2
Haematopoietic and lymphoid	MOLT13	5
Haematopoietic and lymphoid	MOLT16	5
Haematopoietic and lymphoid	MOLT4	5
Haematopoietic and lymphoid	MONOMAC1	4.9
Haematopoietic and lymphoid	MONOMAC6	5
Haematopoietic and lymphoid	MOTN1	4.9
Haematopoietic and lymphoid	MUTZ5	4.9
Haematopoietic and lymphoid	MV411	4.7
Haematopoietic and lymphoid	NALM19	5.1
Haematopoietic and lymphoid	NALM1	5.2
Haematopoietic and lymphoid	NALM6	5.2
Haematopoietic and lymphoid	NAMALWA	5.4
Haematopoietic and lymphoid	NB4	5.1
Haematopoietic and lymphoid	NCIH929	5.5
Haematopoietic and lymphoid	NCO2	5.2
Haematopoietic and lymphoid	NOMO1	4.8
Haematopoietic and lymphoid	NUDHL1	5.6
Haematopoietic and lymphoid	NUDUL1	5.7
Haematopoietic and lymphoid	OCIAML2	5.1
Haematopoietic and lymphoid	OCIAML3	4.6
Haematopoietic and lymphoid	OCIAML5	5
Haematopoietic and lymphoid	OCILY10	5.2
Haematopoietic and lymphoid	OCILY19	5.1
Haematopoietic and lymphoid	OCILY3	5.1
Haematopoietic and lymphoid	OCIM1	4.9
Haematopoietic and lymphoid	OPM2	5.4
Haematopoietic and lymphoid	P12ICHIKAWA	5.6
Haematopoietic and lymphoid	P31FUJ	4.8
Haematopoietic and lymphoid	P3HR1	5.2
Haematopoietic and lymphoid	PCM6	5.1
Haematopoietic and lymphoid	PEER	5.4
Haematopoietic and lymphoid	PF382	4.7
Haematopoietic and lymphoid	PFEIFFER	5.6
Haematopoietic and lymphoid	PL21	5.4
Haematopoietic and lymphoid	RAJI	5.6
Haematopoietic and lymphoid	RCHACV	5
Haematopoietic and lymphoid	REC1	5.4
Haematopoietic and lymphoid	REH	5.2
Haematopoietic and lymphoid	RI1	5.4
Haematopoietic and lymphoid	RL	5.9
Haematopoietic and lymphoid	RPMI8226	5.5
Haematopoietic and lymphoid	RPMI8402	5
Haematopoietic and lymphoid	RS411	4.8
Haematopoietic and lymphoid	SEM	5
Haematopoietic and lymphoid	SET2	5
Haematopoietic and lymphoid	SIGM5	5.3
Haematopoietic and lymphoid	SKM1	5.3
Haematopoietic and lymphoid	SKMM2	5.5
Haematopoietic and lymphoid	SR786	4.9
Haematopoietic and lymphoid	ST486	5.5
Haematopoietic and lymphoid	SUDHL10	4.9
Haematopoietic and lymphoid	SUDHL1	5.2
Haematopoietic and lymphoid	SUDHL4	5.3
Haematopoietic and lymphoid	SUDHL5	5
Haematopoietic and lymphoid	SUDHL6	4.8
Haematopoietic and lymphoid	SUDHL8	5
Haematopoietic and lymphoid	SUPB15	5
Haematopoietic and lymphoid	SUPHD1	4.9
Haematopoietic and lymphoid	SUPM2	4.6
Haematopoietic and lymphoid	SUPT11	5
Haematopoietic and lymphoid	SUPT1	5.4
Haematopoietic and lymphoid	TALL1	5
Haematopoietic and lymphoid	TF1	5
Haematopoietic and lymphoid	THP1	4.6
Haematopoietic and lymphoid	TO175T	5.4
Haematopoietic and lymphoid	TOLEDO	4.9
Haematopoietic and lymphoid	U266B1	5.3
Haematopoietic and lymphoid	U937	5
Haematopoietic and lymphoid	UT7	5
Haematopoietic and lymphoid	WSUDLCL2	5.7
Kidney	769P	4.9
Kidney	786O	4.7
Kidney	A498	5.4
Kidney	A704	5
Kidney	ACHN	5
Kidney	BFTC909	4.9
Kidney	CAKI1	4.8
Kidney	CAKI2	4.7
Kidney	CAL54	4.9
Kidney	KMRC1	5.5
Kidney	KMRC20	4.9
Kidney	KMRC2	5.1
Kidney	KMRC3	5.2
Kidney	OSRC2	4.7
Kidney	RCC10RGB	5
Kidney	SNU1272	4.7
Kidney	SNU349	5.4
Kidney	TUHR10TKB	4.5
Kidney	TUHR14TKB	4.8
Kidney	TUHR4TKB	5
Kidney	VMRCRCW	5.3
Kidney	VMRCRCZ	5.1
Large intestine	C2BBE1	5.1
Large intestine	CCK81	4.7
Large intestine	CL11	4.8
Large intestine	CL14	5.1
Large intestine	CL34	4.9
Large intestine	CL40	5.4
Large intestine	COLO205	5
Large intestine	COLO320	5.2
Large intestine	COLO678	4.9
Large intestine	CW2	5.1
Large intestine	DLD1	5
Large intestine	GP2D	4.5
Large intestine	HCC56	5
Large intestine	HCT116	4.9
Large intestine	HCT15	5.1
Large intestine	HS675T	4.9
Large intestine	HS698T	5
Large intestine	HT115	4.3
Large intestine	HT29	5.4
Large intestine	HT55	5.2
Large intestine	KM12	4.9
Large intestine	LOVO	5
Large intestine	LS1034	5
Large intestine	LS123	5
Large intestine	LS180	4.8
Large intestine	LS411N	5
Large intestine	LS513	4.9
Large intestine	MDST8	4.9
Large intestine	NCIH508	4.9
Large intestine	NCIH716	4.9
Large intestine	NCIH747	5.1
Large intestine	OUMS23	5.2
Large intestine	RCM1	4.7
Large intestine	RKO	5.1
Large intestine	SKCO1	4.8
Large intestine	SNU1040	4.9
Large intestine	SNU1197	5
Large intestine	SNU175	5.5
Large intestine	SNU283	5.6
Large intestine	SNU407	4.9
Large intestine	SNU503	5.1
Large intestine	SNU61	5.1
Large intestine	SNU81	4.5
Large intestine	SNUC1	5.2
Large intestine	SNUC2A	4.4
Large intestine	SNUC4	4.5
Large intestine	SNUC5	4.9
Large intestine	SW1116	4.8
Large intestine	SW1417	5.1
Large intestine	SW1463	5.1
Large intestine	SW403	4.9
Large intestine	SW480	4.8
Large intestine	SW48	4.7
Large intestine	SW620	4.5
Large intestine	SW837	4.8
Large intestine	SW948	5
Large intestine	T84	5.3
Liver	ALEXANDERCELLS	5.4
Liver	C3A	5.5
Liver	HEP3B217	5
Liver	HEPG2	4.9
Liver	HLE	5
Liver	HLF	4.9
Liver	HUH1	5.2
Liver	HUH6	5
Liver	HUH7	5.1
Liver	JHH1	4.8
Liver	JHH2	4.8
Liver	JHH4	5.1
Liver	JHH5	4.5
Liver	JHH6	4.6
Liver	JHH7	5.4
Liver	LI7	4.5
Liver	PLCPRF5	5
Liver	SKHEP1	4.6
Liver	SNU182	5
Liver	SNU387	5.2
Liver	SNU398	5.2
Liver	SNU423	5.2
Liver	SNU449	5.2
Liver	SNU475	4.9
Liver	SNU761	4.8
Liver	SNU878	5.7
Liver	SNU886	4.9
Lung	A549	5.4
Lung	ABC1	4.9
Lung	BEN	4.6
Lung	CAL12T	5.3
Lung	CALU1	5.1
Lung	CALU3	5.1
Lung	CALU6	5.6
Lung	CHAGOK1	5
Lung	COLO668	5.1
Lung	COLO699	4.9
Lung	CORL105	4.9
Lung	CORL23	5.3
Lung	CORL24	4.7
Lung	CORL279	4.6
Lung	CORL311	5.3
Lung	CORL47	4.6
Lung	CORL51	4.8
Lung	CORL88	4.8
Lung	CORL95	4.8
Lung	CPCN	5
Lung	DMS114	4.8
Lung	DMS153	5.3
Lung	DMS273	4.7
Lung	DMS454	4.9
Lung	DMS53	4.9
Lung	DMS79	5.1
Lung	DV90	5.3
Lung	EBC1	4.8
Lung	EPLC272H	6
Lung	HARA	5
Lung	HCC1171	4.4
Lung	HCC1195	5.4
Lung	HCC15	5
Lung	HCC2279	4.8
Lung	HCC2935	4.5
Lung	HCC33	4.9
Lung	HCC366	4.5
Lung	HCC4006	5
Lung	HCC44	5.3
Lung	HCC78	5.1
Lung	HCC827	5
Lung	HCC95	4.7
Lung	HLC1	4.8
Lung	HLFA	4.9
Lung	HS229T	4.3
Lung	HS618T	4.8
Lung	IALM	5.2
Lung	KNS62	5.5
Lung	LC1F	5.3
Lung	LC1SQSF	4.8
Lung	LCLC103H	4.7
Lung	LCLC97TM1	4.6
Lung	LK2	4.7
Lung	LOUNH91	5.3
Lung	LU65	5.7
Lung	LU99	5.1
Lung	LUDLU1	5.4
Lung	LXF289	5.1
Lung	MORCPR	5.1
Lung	NCIH1048	4.7
Lung	NCIH1092	4.5
Lung	NCIH1105	4.9
Lung	NCIH1155	4.9
Lung	NCIH1184	5.2
Lung	NCIH1299	5.4
Lung	NCIH1339	4.9
Lung	NCIH1341	4.4
Lung	NCIH1355	4.8
Lung	NCIH1373	5.3
Lung	NCIH1385	5.6
Lung	NCIH1395	5.1
Lung	NCIH1435	5.1
Lung	NCIH1436	4.5
Lung	NCIH1437	4.9
Lung	NCIH146	5.2
Lung	NCIH1563	5
Lung	NCIH1568	4.8
Lung	NCIH1573	5
Lung	NCIH1581	5
Lung	NCIH1618	5.1
Lung	NCIH1623	4.7
Lung	NCIH1648	4.8
Lung	NCIH1650	5.1
Lung	NCIH1651	4.9
Lung	NCIH1666	5
Lung	NCIH1693	5.3
Lung	NCIH1694	4.9
Lung	NCIH1703	5.1
Lung	NCIH1734	4.9
Lung	NCIH1755	4.8
Lung	NCIH1781	5.1
Lung	NCIH1792	4.7
Lung	NCIH1793	4.9
Lung	NCIH1836	5
Lung	NCIH1838	5.1
Lung	NCIH1869	5.1
Lung	NCIH1876	4.9
Lung	NCIH1915	4.9
Lung	NCIH1930	4.8
Lung	NCIH1944	5.1
Lung	NCIH1963	4.8
Lung	NCIH196	4.9
Lung	NCIH1975	5.1
Lung	NCIH2009	5.3
Lung	NCIH2023	4.9
Lung	NCIH2029	5.1
Lung	NCIH2030	5
Lung	NCIH2066	4.9
Lung	NCIH2081	4.8
Lung	NCIH2085	4.9
Lung	NCIH2087	4.6
Lung	NCIH209	4.6
Lung	NCIH2106	4.7
Lung	NCIH2110	4.9
Lung	NCIH211	5.4
Lung	NCIH2122	5.1
Lung	NCIH2126	5
Lung	NCIH2141	4.7
Lung	NCIH2170	4.9
Lung	NCIH2171	4.9
Lung	NCIH2172	4.8
Lung	NCIH2196	5
Lung	NCIH2227	4.9
Lung	NCIH2228	4.5
Lung	NCIH226	5
Lung	NCIH2286	5.2
Lung	NCIH2291	5.2
Lung	NCIH2342	5.2
Lung	NCIH2347	5.4
Lung	NCIH23	5.2
Lung	NCIH2405	5
Lung	NCIH2444	4.9
Lung	NCIH292	5
Lung	NCIH322	5.8
Lung	NCIH3255	4.6
Lung	NCIH358	4.8
Lung	NCIH441	4.9
Lung	NCIH446	4.9
Lung	NCIH460	5.1
Lung	NCIH510	5
Lung	NCIH520	4.7
Lung	NCIH522	4.9
Lung	NCIH524	6.1
Lung	NCIH526	5.2
Lung	NCIH596	4.5
Lung	NCIH647	5.1
Lung	NCIH650	5.1
Lung	NCIH661	5.2
Lung	NCIH69	5.1
Lung	NCIH727	4.9
Lung	NCIH810	5
Lung	NCIH82	4.4
Lung	NCIH838	4.7
Lung	NCIH841	4.9
Lung	NCIH854	5.2
Lung	NCIH889	4.9
Lung	PC14	4.8
Lung	RERFLCAD1	5
Lung	RERFLCAD2	5.4
Lung	RERFLCAI	4.9
Lung	RERFLCKJ	4.7
Lung	RERFLCMS	5.3
Lung	RERFLCSQ1	4.9
Lung	SBC5	5.2
Lung	SCLC21H	4.9
Lung	SHP77	5.3
Lung	SKLU1	5.2
Lung	SKMES1	5.2
Lung	SQ1	5.1
Lung	SW1271	4.6
Lung	SW1573	4.8
Lung	SW900	4.6
Lung	VMRCLCD	5
Lung	VMRCLCP	4.6
Oesophagus	COLO680N	4.5
Oesophagus	ECGI10	4.9
Oesophagus	KYSE140	5.1
Oesophagus	KYSE150	4.8
Oesophagus	KYSE180	5.4
Oesophagus	KYSE270	4.9
Oesophagus	KYSE30	5.6
Oesophagus	KYSE410	5
Oesophagus	KYSE450	5.2
Oesophagus	KYSE510	5.2
Oesophagus	KYSE520	5.3
Oesophagus	KYSE70	5.1
Oesophagus	OE19	4.8
Oesophagus	OE33	4.7
Oesophagus	TE10	5.1
Oesophagus	TE11	5
Oesophagus	TE14	4.5
Oesophagus	TE15	5
Oesophagus	TE1	4.7
Oesophagus	TE4	4.7
Oesophagus	TE5	5
Oesophagus	TE6	4.8
Oesophagus	TE8	4.3
Oesophagus	TE9	5.1
Oesophagus	TT	5.4
Ovary	59M	4.9
Ovary	A2780	4.7
Ovary	CAOV3	4.8
Ovary	CAOV4	5.3
Ovary	COLO704	5
Ovary	COV318	4.9
Ovary	COV362	4.7
Ovary	COV434	5
Ovary	COV504	4.6
Ovary	COV644	4.4
Ovary	EFO21	5.2
Ovary	EFO27	4.6
Ovary	ES2	5.3
Ovary	FUOV1	5.2
Ovary	HEYA8	5.4
Ovary	HS571T	4.6
Ovary	IGROV1	4.8
Ovary	JHOC5	5.2
Ovary	JHOM1	5.1
Ovary	JHOM2B	4.4
Ovary	JHOS2	5.1
Ovary	JHOS4	5
Ovary	KURAMOCHI	5.1
Ovary	MCAS	5.4
Ovary	NIHOVCAR3	5
Ovary	OAW28	4.5
Ovary	OAW42	4.7
Ovary	OC314	5.3
Ovary	OC316	5.1
Ovary	ONCODG1	4.7
Ovary	OV56	5.5
Ovary	OV7	5
Ovary	OV90	5.2
Ovary	OVCAR4	4.7
Ovary	OVCAR8	4.6
Ovary	OVISE	4.7
Ovary	OVK18	5
Ovary	OVKATE	4.6
Ovary	OVMANA	4.7
Ovary	OVSAHO	5
Ovary	OVTOKO	5.8
Ovary	RMGI	5.3
Ovary	RMUGS	4.9
Ovary	SKOV3	4.9
Ovary	SNU119	4.3
Ovary	SNU840	5.2
Ovary	SNU8	5.7
Ovary	TOV112D	5
Ovary	TOV21G	4.8
Ovary	TYKNU	4.8
Pancreas	ASPC1	5
Pancreas	BXPC3	4.8
Pancreas	CAPAN1	4.9
Pancreas	CAPAN2	4.6
Pancreas	CFPAC1	5.3
Pancreas	DANG	4.6
Pancreas	HPAC	4.7
Pancreas	HPAFII	5.3
Pancreas	HS766T	4.9
Pancreas	HUPT3	4.9
Pancreas	HUPT4	5.5
Pancreas	KCIMOH1	5.2
Pancreas	KLM1	4.8
Pancreas	KP2	5
Pancreas	KP3	5.3
Pancreas	KP4	4.7
Pancreas	L33	4.8
Pancreas	MIAPACA2	4.6
Pancreas	PANC0203	5.1
Pancreas	PANC0213	4.7
Pancreas	PANC0327	5.3
Pancreas	PANC0403	4.8
Pancreas	PANC0504	6.9
Pancreas	PANC0813	5.5
Pancreas	PANC1005	4.9
Pancreas	PANC1	5.3
Pancreas	PATU8902	4.9
Pancreas	PATU8988S	5.8
Pancreas	PATU8988T	5.1
Pancreas	PK1	4.8
Pancreas	PK45H	5
Pancreas	PK59	5.4
Pancreas	PL45	5.3
Pancreas	PSN1	4.9
Pancreas	QGP1	4.7
Pancreas	SNU213	4.6
Pancreas	SNU324	4.7
Pancreas	SNU410	4.6
Pancreas	SU8686	5.1
Pancreas	SUIT2	5.3
Pancreas	SW1990	5.2
Pancreas	T3M4	4.8
Pancreas	TCCPAN2	5.1
Pancreas	YAPC	4.7
Pleura	ACCMESO1	4.8
Pleura	DM3	5.2
Pleura	ISTMES1	4.8
Pleura	ISTMES2	4.8
Pleura	JL1	5.1
Pleura	MPP89	4.7
Pleura	MSTO211H	5.1
Pleura	NCIH2052	5.2
Pleura	NCIH2452	5.1
Pleura	NCIH28	5
Prostate	22RV1	5.1
Prostate	DU145	5.1
Prostate	LNCAPCLONEFGC	4.8
Prostate	MDAPCA2B	4.9
Prostate	NCIH660	4.9
Prostate	PC3	5.4
Prostate	VCAP	5.5
Salivary gland	A253	4.7
Salivary gland	YD15	5.1
Skin	A101D	5.2
Skin	A2058	4.6
Skin	A375	4.5
Skin	C32	4.9
Skin	CHL1	4.5
Skin	CJM	4.8
Skin	COLO679	5.1
Skin	COLO741	5.1
Skin	COLO783	4.8
Skin	COLO792	5.3
Skin	COLO800	4.8
Skin	COLO818	4.9
Skin	COLO829	4.8
Skin	COLO849	4.5
Skin	G361	5
Skin	GRM	4.8
Skin	HMCB	4.4
Skin	HS294T	5
Skin	HS600T	4.8
Skin	HS688AT	4.7
Skin	HS695T	5.1
Skin	HS839T	4.7
Skin	HS852T	4.7
Skin	HS895T	5.3
Skin	HS934T	5
Skin	HS936T	5.2
Skin	HS939T	4.5
Skin	HS940T	4.7
Skin	HS944T	4.9
Skin	HT144	4.7
Skin	IGR1	4.9
Skin	IGR37	4.8
Skin	IGR39	5
Skin	IPC298	4.3
Skin	K029AX	4.7
Skin	LOXIMVI	5.2
Skin	MALME3M	5.2
Skin	MDAMB435S	4.6
Skin	MELHO	5.2
Skin	MELJUSO	4.8
Skin	MEWO	5.1
Skin	RPMI7951	4.9
Skin	RVH421	5.3
Skin	SH4	4.8
Skin	SKMEL1	5.1
Skin	SKMEL24	4.7
Skin	SKMEL28	4.7
Skin	SKMEL2	4.8
Skin	SKMEL30	4.8
Skin	SKMEL31	4.9
Skin	SKMEL3	4.9
Skin	SKMEL5	4.9
Skin	UACC257	4.9
Skin	UACC62	4.8
Skin	WM115	4.7
Skin	WM1799	4.7
Skin	WM2664	4.7
Skin	WM793	4.5
Skin	WM88	4.9
Skin	WM983B	4.5
Small intestine	HUTU80	5
Soft tissue	A204	4.6
Soft tissue	G401	5.2
Soft tissue	G402	5.1
Soft tissue	GCT	4.5
Soft tissue	HS729	5
Soft tissue	HT1080	5.3
Soft tissue	KYM1	4.7
Soft tissue	MESSA	5.1
Soft tissue	RD	4.7
Soft tissue	RH30	4.9
Soft tissue	RH41	4.7
Soft tissue	RKN	5.3
Soft tissue	S117	5.3
Soft tissue	SJRH30	5.3
Soft tissue	SKLMS1	4.8
Soft tissue	SKUT1	5.1
Soft tissue	TE125T	5
Soft tissue	TE159T	5
Soft tissue	TE441T	5.1
Soft tissue	TE617T	5.5
Stomach	2313287	4.9
Stomach	AGS	5.1
Stomach	AZ521	5.3
Stomach	ECC10	4.8
Stomach	ECC12	4.8
Stomach	FU97	5.1
Stomach	GCIY	5.4
Stomach	GSS	4.6
Stomach	GSU	4.9
Stomach	HGC27	4.5
Stomach	HS746T	4.9
Stomach	HUG1N	4.9
Stomach	IM95	4.9
Stomach	KATOIII	5.1
Stomach	KE39	5.2
Stomach	LMSU	4.4
Stomach	MKN1	5
Stomach	MKN45	4.6
Stomach	MKN74	4.9
Stomach	MKN7	5.1
Stomach	NCCSTCK140	4.9
Stomach	NCIN87	4.7
Stomach	NUGC2	4.7
Stomach	NUGC3	4.6
Stomach	NUGC4	5.6
Stomach	OCUM1	5.4
Stomach	RERFGC1B	4.6
Stomach	SH10TC	5.4
Stomach	SNU16	4.9
Stomach	SNU1	5.2
Stomach	SNU216	5.2
Stomach	SNU520	4.6
Stomach	SNU5	4.8
Stomach	SNU601	4.7
Stomach	SNU620	4.6
Stomach	SNU668	5.4
Stomach	SNU719	5
Stomach	TGBC11TKB	4.9
Thyroid	8305C	4.9
Thyroid	8505C	5.1
Thyroid	BCPAP	4.1
Thyroid	BHT101	5.1
Thyroid	CAL62	4.9
Thyroid	CGTHW1	4.5
Thyroid	FTC133	5
Thyroid	FTC238	5.1
Thyroid	ML1	4.7
Thyroid	SW579	4.9
Thyroid	TT2609C02	4.9
Thyroid	TT	5
Upper aerodigestive tract	BHY	5.1
Upper aerodigestive tract	BICR16	5.5
Upper aerodigestive tract	BICR18	5.2
Upper aerodigestive tract	BICR22	5.1
Upper aerodigestive tract	BICR31	4.9
Upper aerodigestive tract	BICR56	5.1
Upper aerodigestive tract	BICR6	5.1
Upper aerodigestive tract	CAL27	4.9
Upper aerodigestive tract	CAL33	4.8
Upper aerodigestive tract	DETROIT562	5.3
Upper aerodigestive tract	FADU	5.1
Upper aerodigestive tract	HS840T	5
Upper aerodigestive tract	HSC2	4.7
Upper aerodigestive tract	HSC3	5.1
Upper aerodigestive tract	HSC4	4.7
Upper aerodigestive tract	PECAPJ15	5
Upper aerodigestive tract	PECAPJ34CLONEC12	5
Upper aerodigestive tract	PECAPJ41CLONED2	4.8
Upper aerodigestive tract	PECAPJ49	5.1
Upper aerodigestive tract	SCC15	4.9
Upper aerodigestive tract	SCC25	5.2
Upper aerodigestive tract	SCC4	5.2
Upper aerodigestive tract	SCC9	5.2
Upper aerodigestive tract	SNU1076	5.7
Upper aerodigestive tract	SNU1214	5.4
Upper aerodigestive tract	SNU46	4.9
Upper aerodigestive tract	SNU899	5.1
Upper aerodigestive tract	YD10B	5.1
Upper aerodigestive tract	YD38	5.5
Upper aerodigestive tract	YD8	5.5
Urinary tract	5637	4.6
Urinary tract	639V	4.7
Urinary tract	647V	4.9
Urinary tract	BC3C	5.3
Urinary tract	BFTC905	5
Urinary tract	CAL29	5.3
Urinary tract	HS172T	5.4
Urinary tract	HT1197	4.7
Urinary tract	HT1376	4.9
Urinary tract	J82	5.5
Urinary tract	JMSU1	4.9
Urinary tract	KMBC2	4.8
Urinary tract	KU1919	4.4
Urinary tract	RT11284	5
Urinary tract	RT112	4.8
Urinary tract	RT4	5.3
Urinary tract	SCABER	5.3
Urinary tract	SW1710	4.8
Urinary tract	SW780	4.8
Urinary tract	T24	4.8
Urinary tract	TCCSUP	5
Urinary tract	UMUC1	5.2
Urinary tract	UMUC3	5.4
Urinary tract	VMCUB1	5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0.2
Adrenal gland	0.1
Appendix	0.1
Bone marrow	0.3
Breast	0.2
Cerebral cortex	0.2
Cervix, uterine	0.2
Colon	0.1
Duodenum	0.3
Endometrium	0.4
Epididymis	0.5
Esophagus	0.1
Fallopian tube	0.2
Gallbladder	0.2
Heart muscle	0.2
Kidney	0.2
Liver	0
Lung	0.3
Lymph node	0.2
Ovary	0.3
Pancreas	0
Parathyroid gland	0.3
Placenta	0.2
Prostate	0.2
Rectum	0.1
Salivary gland	0
Seminal vesicle	0.2
Skeletal muscle	0
Skin	0.5
Small intestine	0.1
Smooth muscle	0.3
Spleen	0.3
Stomach	0.1
Testis	1.8
Thyroid gland	0.3
Tonsil	0.1
Urinary bladder	0.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25635434	Overexpression	Non-Small Cell Lung Cancer	As a novel molecular marker of non-small cell lung cancer (NSCLC), PRDI-BF1 and RIZ homology domain containing protein 14 (PRDM14) is over-expressed in NSCLC tumor tissues.
23690269	Overexpression	Non-Small Cell Lung Cancer	PRDM14 was found to be increased expression in 35.65 % cases (46/129) for primary tumors and 39.68 % cases (25/63) for paired metastatic lymph nodes. Increased expression of PRDM14 correlated with differentiation of tumor cells significantly (P = 0.008).
20840815	altered expression	Non-Small Cell Lung Cancer	The positive cytoplasmic expression of PRDM14 in highly differentiated NSCLC, the low expression of PRDM14 in poorly differentiated NSCLC. The results of Western blot showed that there were significant difference between the two groups (P<0.001); expression of PRDM14 was conspicuous in NSCLC specimens but low in paracancerous tissues.
17942894	Overexpression	Breast Carcinoma	We found that PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that expression of PRDM14 protein is also up-regulated.
28423353	Overexpression	Breast Carcinoma	PRDM14 expression was markedly increased in many different cancer types and correlated with poor survival of breast cancer patients.

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
TGCT	Testicular Germ Cell Tumors	150	0.26	0.00134	2	16	82	Gain

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
TGCT	Testicular Germ Cell Tumors	-0.515	0	0	156	NA	NA	NS/NA

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype [ TOP ]
There is no record.

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
TGCT	Testicular Germ Cell Tumors	134	1591916516.802	0.16	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
TGCT	Testicular Germ Cell Tumors	81	0.22	0.0481	Higher

> Grade [ TOP ]
There is no data.

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PRDM14.

Summary
Symbol	PRDM14
Name	PR/SET domain 14
Aliases	PFM11; PR domain-containing 14; PR domain-containing protein 14; PR domain zinc finger protein 14
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for PRDM14.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25663945	Lung Carcinoma	partner	ZNF703; MYC	correlation	Amplification of the ZNF703, PRDM14 and MYC genes were highly correlated suggesting that the genes displaying high copy number changes on chromosome 8 collaborate during lung carcinogenesis.