CR2Cancer

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00856 SET domain

Function

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3K9	H3K9me	20084102

> Gene Ontology [ TOP ]
Biological Process	GO:0006479 protein methylation GO:0007568 aging GO:0008213 protein alkylation GO:0008340 determination of adult lifespan GO:0010259 multicellular organism aging GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0032259 methylation GO:0034968 histone lysine methylation GO:0043414 macromolecule methylation
Molecular Function	GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00310 Lysine degradation
Reactome	-

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4576210	c.523T>C	p.S175P	Substitution - Missense	Bone
COSM1683735	c.3376_3378delGTT	p.V1126delV	Deletion - In frame	Central_nervous_system
COSM895020	c.3632G>A	p.R1211Q	Substitution - Missense	Endometrium
COSM368357	c.3989C>T	p.T1330I	Substitution - Missense	Lung
COSM1683736	c.5000_5001delAG	p.E1667fs*34	Deletion - Frameshift	Kidney
COSM3750308	c.1008G>A	p.E336E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4021538	c.470C>T	p.A157V	Substitution - Missense	Stomach
COSM4021560	c.4194A>T	p.G1398G	Substitution - coding silent	Stomach
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Upper_aerodigestive_tract
COSM4801918	c.2158T>C	p.S720P	Substitution - Missense	Liver
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Pancreas
COSM3376679	c.2622G>A	p.T874T	Substitution - coding silent	Pancreas
COSM1320049	c.2772T>A	p.D924E	Substitution - Missense	Ovary
COSM326234	c.4975G>T	p.A1659S	Substitution - Missense	Lung
COSM3472828	c.3104C>T	p.P1035L	Substitution - Missense	Skin
COSM2230162	c.4589C>T	p.P1530L	Substitution - Missense	Large_intestine
COSM4517169	c.2899_2900CC>TT	p.P967F	Substitution - Missense	Skin
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM263089	c.3838A>G	p.I1280V	Substitution - Missense	Large_intestine
COSM895012	c.2337C>T	p.S779S	Substitution - coding silent	Endometrium
COSM6009078	c.385-7C>T	p.?	Unknown	Skin
COSM2230170	c.4852A>G	p.S1618G	Substitution - Missense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM3472825	c.2864C>T	p.S955F	Substitution - Missense	Skin
COSM5428769	c.2705C>T	p.P902L	Substitution - Missense	Oesophagus
COSM4021562	c.4278T>A	p.N1426K	Substitution - Missense	Stomach
COSM4771067	c.4758T>C	p.H1586H	Substitution - coding silent	Pleura
COSM1333443	c.81G>A	p.P27P	Substitution - coding silent	Stomach
COSM4938369	c.444A>G	p.I148M	Substitution - Missense	Liver
COSM2230149	c.4146C>T	p.G1382G	Substitution - coding silent	Large_intestine
COSM895017	c.3108C>T	p.P1036P	Substitution - coding silent	Endometrium
COSM3801562	c.4279C>T	p.Q1427*	Substitution - Nonsense	Breast
COSM5792694	c.1083G>A	p.P361P	Substitution - coding silent	Breast
COSM3862517	c.2931C>T	p.P977P	Substitution - coding silent	Skin
COSM4616068	c.862_864delGAG	p.E288delE	Deletion - In frame	Large_intestine
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Small_intestine
COSM1667163	c.1409C>A	p.S470Y	Substitution - Missense	Large_intestine
COSM4717500	c.2520T>C	p.T840T	Substitution - coding silent	Large_intestine
COSM342306	c.2362G>A	p.G788R	Substitution - Missense	Lung
COSM4933494	c.4888A>G	p.S1630G	Substitution - Missense	Liver
COSM5745577	c.4858G>T	p.A1620S	Substitution - Missense	Pancreas
COSM4219256	c.2110G>C	p.A704P	Substitution - Missense	Oesophagus
COSM5735268	c.3713G>A	p.S1238N	Substitution - Missense	Small_intestine
COSM5563331	c.5017C>A	p.Q1673K	Substitution - Missense	Prostate
COSM6006490	c.1198G>A	p.G400S	Substitution - Missense	Prostate
COSM4422537	c.1374G>T	p.M458I	Substitution - Missense	Kidney
COSM3750308	c.1008G>A	p.E336E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4645769	c.702G>T	p.E234D	Substitution - Missense	Large_intestine
COSM3472817	c.99C>T	p.F33F	Substitution - coding silent	Skin
COSM3472820	c.1213C>T	p.R405W	Substitution - Missense	Skin
COSM1333460	c.4333G>A	p.D1445N	Substitution - Missense	Large_intestine
COSM5821764	c.4561G>T	p.E1521*	Substitution - Nonsense	Liver
COSM4486730	c.3098C>T	p.P1033L	Substitution - Missense	Skin
COSM5977857	c.159_160insA	p.F56fs*7	Insertion - Frameshift	Upper_aerodigestive_tract
COSM423662	c.3369_3371delTGT	p.V1126delV	Deletion - In frame	Breast
COSM423663	c.3889A>T	p.S1297C	Substitution - Missense	Breast
COSM3862515	c.2090C>T	p.T697I	Substitution - Missense	Skin
COSM5477567	c.4823C>T	p.S1608L	Substitution - Missense	Large_intestine
COSM674885	c.4584G>T	p.Q1528H	Substitution - Missense	Lung
COSM1666297	c.4798T>C	p.S1600P	Substitution - Missense	Eye
COSM5353466	c.4886C>T	p.A1629V	Substitution - Missense	Large_intestine
COSM4608209	c.5152G>T	p.E1718*	Substitution - Nonsense	Adrenal_gland
COSM895015	c.2809A>G	p.T937A	Substitution - Missense	Endometrium
COSM4021554	c.3461C>A	p.S1154Y	Substitution - Missense	Stomach
COSM3801560	c.2299G>A	p.G767R	Substitution - Missense	Breast
COSM145807	c.3502G>A	p.V1168M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1600689	c.4324C>T	p.Q1442*	Substitution - Nonsense	Liver
COSM4576213	c.4836C>G	p.H1612Q	Substitution - Missense	Bone
COSM3472830	c.3709C>T	p.P1237S	Substitution - Missense	Skin
COSM674889	c.1221A>C	p.R407R	Substitution - coding silent	Lung
COSM895023	c.4241C>T	p.S1414L	Substitution - Missense	Endometrium
COSM4219251	c.1450C>T	p.P484S	Substitution - Missense	Oesophagus
COSM5907993	c.4588C>T	p.P1530S	Substitution - Missense	Skin
COSM3750309	c.3070T>A	p.S1024T	Substitution - Missense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM3710287	c.5074G>A	p.A1692T	Substitution - Missense	Upper_aerodigestive_tract
COSM4970529	c.849T>A	p.D283E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4801918	c.2158T>C	p.S720P	Substitution - Missense	Liver
COSM3930325	c.2878C>T	p.Q960*	Substitution - Nonsense	Urinary_tract
COSM4450099	c.4438delA	p.K1481fs*83	Deletion - Frameshift	Large_intestine
COSM4450099	c.4438delA	p.K1481fs*83	Deletion - Frameshift	Skin
COSM3687737	c.3244T>C	p.S1082P	Substitution - Missense	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM1333457	c.3993C>T	p.T1331T	Substitution - coding silent	Large_intestine
COSM3723186	c.2634A>G	p.V878V	Substitution - coding silent	Upper_aerodigestive_tract
COSM5548651	c.4331C>T	p.A1444V	Substitution - Missense	Prostate
COSM1333449	c.852T>A	p.D284E	Substitution - Missense	Large_intestine
COSM4219255	c.2104A>C	p.T702P	Substitution - Missense	Skin
COSM1294870	c.1913A>G	p.K638R	Substitution - Missense	Urinary_tract
COSM4517886	c.4536_4537CC>TT	p.H1513Y	Substitution - Missense	Skin
COSM1626374	c.3564G>T	p.G1188G	Substitution - coding silent	Liver
COSM4410156	c.2332C>G	p.H778D	Substitution - Missense	Oesophagus
COSM895009	c.1655A>C	p.D552A	Substitution - Missense	Endometrium
COSM4919122	c.416G>T	p.W139L	Substitution - Missense	Liver
COSM4219251	c.1450C>T	p.P484S	Substitution - Missense	Cervix
COSM3750310	c.4824A>G	p.S1608S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5516128	c.3544_3545insT	p.L1183fs*15	Insertion - Frameshift	Biliary_tract
COSM5799970	c.664G>A	p.E222K	Substitution - Missense	Breast
COSM1185322	c.2338G>T	p.D780Y	Substitution - Missense	Lung
COSM1333456	c.3481C>T	p.P1161S	Substitution - Missense	Large_intestine
COSM1221888	c.4094C>T	p.T1365M	Substitution - Missense	Large_intestine
COSM3862513	c.1211A>C	p.N404T	Substitution - Missense	Skin
COSM5477565	c.640G>T	p.E214*	Substitution - Nonsense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM4912624	c.4338G>A	p.L1446L	Substitution - coding silent	Liver
COSM349751	c.5082G>T	p.P1694P	Substitution - coding silent	Lung
COSM4021536	c.231+2T>C	p.?	Unknown	Stomach
COSM5735266	c.1253G>A	p.R418Q	Substitution - Missense	Small_intestine
COSM895001	c.338T>C	p.L113S	Substitution - Missense	Endometrium
COSM2230103	c.1798_1801delTGTC	p.L601fs*12	Deletion - Frameshift	Large_intestine
COSM5415411	c.1149A>G	p.I383M	Substitution - Missense	Prostate
COSM5473125	c.456T>C	p.I152I	Substitution - coding silent	Large_intestine
COSM4822330	c.2541C>G	p.V847V	Substitution - coding silent	Cervix
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Upper_aerodigestive_tract
COSM5622517	c.3809A>G	p.Y1270C	Substitution - Missense	Oesophagus
COSM4610839	c.852delT	p.D284fs*22	Deletion - Frameshift	Large_intestine
COSM1333449	c.852T>A	p.D284E	Substitution - Missense	Lung
COSM4970529	c.849T>A	p.D283E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1333455	c.2883G>A	p.L961L	Substitution - coding silent	Large_intestine
COSM895002	c.348G>A	p.L116L	Substitution - coding silent	Endometrium
COSM5735262	c.196A>G	p.R66G	Substitution - Missense	Small_intestine
COSM1333445	c.672G>A	p.P224P	Substitution - coding silent	Large_intestine
COSM3862516	c.2291C>T	p.T764I	Substitution - Missense	Skin
COSM4021561	c.4235T>C	p.M1412T	Substitution - Missense	Stomach
COSM4824021	c.1144C>T	p.H382Y	Substitution - Missense	Cervix
COSM3472824	c.2781C>T	p.L927L	Substitution - coding silent	Skin
COSM5352889	c.2961T>C	p.P987P	Substitution - coding silent	Large_intestine
COSM895026	c.4702C>T	p.P1568S	Substitution - Missense	Endometrium
COSM895025	c.4686G>A	p.S1562S	Substitution - coding silent	Upper_aerodigestive_tract
COSM1333447	c.834A>T	p.E278D	Substitution - Missense	Large_intestine
COSM528034	c.3021C>T	p.C1007C	Substitution - coding silent	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Ovary
COSM5460858	c.2105_2106insCTC	p.T702_P703insS	Insertion - In frame	Large_intestine
COSM3773420	c.409C>T	p.L137L	Substitution - coding silent	Kidney
COSM3801564	c.4671C>G	p.V1557V	Substitution - coding silent	Breast
COSM4021547	c.1750G>C	p.D584H	Substitution - Missense	Stomach
COSM2230124	c.3204T>G	p.S1068S	Substitution - coding silent	Large_intestine
COSM2230149	c.4146C>T	p.G1382G	Substitution - coding silent	Stomach
COSM82308	c.2694C>T	p.G898G	Substitution - coding silent	Ovary
COSM1720118	c.721A>G	p.T241A	Substitution - Missense	Skin
COSM674888	c.2020A>G	p.T674A	Substitution - Missense	Lung
COSM2230155	c.4420G>T	p.A1474S	Substitution - Missense	Soft_tissue
COSM4717502	c.2974A>T	p.T992S	Substitution - Missense	Large_intestine
COSM2230102	c.1783T>G	p.L595V	Substitution - Missense	Large_intestine
COSM5968782	c.4348T>C	p.C1450R	Substitution - Missense	Upper_aerodigestive_tract
COSM1333449	c.852T>A	p.D284E	Substitution - Missense	Stomach
COSM5977857	c.159_160insA	p.F56fs*7	Insertion - Frameshift	Upper_aerodigestive_tract
COSM4902159	c.2967C>T	p.L989L	Substitution - coding silent	Skin
COSM3801565	c.4739G>A	p.R1580K	Substitution - Missense	Breast
COSM4431288	c.494C>A	p.S165Y	Substitution - Missense	Oesophagus
COSM3801559	c.1567G>C	p.E523Q	Substitution - Missense	Breast
COSM2230141	c.3775G>T	p.E1259*	Substitution - Nonsense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Central_nervous_system
COSM365947	c.2392C>T	p.P798S	Substitution - Missense	Stomach
COSM4021540	c.1082C>T	p.P361L	Substitution - Missense	Stomach
COSM4576212	c.1802T>G	p.L601R	Substitution - Missense	Bone
COSM5745575	c.2978T>C	p.V993A	Substitution - Missense	Pancreas
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM5704894	c.3401T>G	p.F1134C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3934052	c.4241C>G	p.S1414W	Substitution - Missense	Oesophagus
COSM257801	c.3312A>C	p.E1104D	Substitution - Missense	Large_intestine
COSM1333451	c.2535A>G	p.E845E	Substitution - coding silent	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Central_nervous_system
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM3676773	c.4416A>C	p.K1472N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3740597	c.1232G>A	p.R411H	Substitution - Missense	Liver
COSM5682932	c.874G>T	p.E292*	Substitution - Nonsense	Soft_tissue
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM895010	c.1925C>T	p.A642V	Substitution - Missense	Endometrium
COSM2230149	c.4146C>T	p.G1382G	Substitution - coding silent	Biliary_tract
COSM5968787	c.5047C>T	p.R1683C	Substitution - Missense	Upper_aerodigestive_tract
COSM4997169	c.3658_3659insC	p.H1221fs*5	Insertion - Frameshift	Upper_aerodigestive_tract
COSM3738080	c.3130G>A	p.A1044T	Substitution - Missense	Soft_tissue
COSM4792958	c.682C>A	p.Q228K	Substitution - Missense	Liver
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Stomach
COSM5582228	c.1081C>T	p.P361S	Substitution - Missense	Skin
COSM1333443	c.81G>A	p.P27P	Substitution - coding silent	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Stomach
COSM1747696	c.2637G>C	p.K879N	Substitution - Missense	Urinary_tract
COSM3360276	c.2493A>G	p.K831K	Substitution - coding silent	Kidney
COSM1741228	c.3445C>T	p.L1149L	Substitution - coding silent	Urinary_tract
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Upper_aerodigestive_tract
COSM4021551	c.2917C>T	p.P973S	Substitution - Missense	Stomach
COSM5048982	c.3875A>G	p.N1292S	Substitution - Missense	Oesophagus
COSM4717503	c.4394C>A	p.T1465N	Substitution - Missense	Large_intestine
COSM5377480	c.4641C>T	p.P1547P	Substitution - coding silent	Skin
COSM2230114	c.2508T>C	p.G836G	Substitution - coding silent	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM4949439	c.512-1G>C	p.?	Unknown	Liver
COSM5071994	c.1073T>G	p.F358C	Substitution - Missense	Large_intestine
COSM2230161	c.4551A>G	p.T1517T	Substitution - coding silent	Large_intestine
COSM4021541	c.1216C>T	p.R406W	Substitution - Missense	Stomach
COSM4486448	c.3054C>T	p.S1018S	Substitution - coding silent	Skin
COSM5821160	c.1448A>T	p.H483L	Substitution - Missense	Liver
COSM3417980	c.4323G>A	p.K1441K	Substitution - coding silent	Large_intestine
COSM4399807	c.459G>A	p.E153E	Substitution - coding silent	Skin
COSM5745573	c.2663T>C	p.L888P	Substitution - Missense	Pancreas
COSM1333447	c.834A>T	p.E278D	Substitution - Missense	Biliary_tract
COSM5433823	c.3642C>T	p.H1214H	Substitution - coding silent	Oesophagus
COSM1667163	c.1409C>A	p.S470Y	Substitution - Missense	Large_intestine
COSM4021546	c.1600A>G	p.T534A	Substitution - Missense	Stomach
COSM2230117	c.2626A>G	p.S876G	Substitution - Missense	Large_intestine
COSM314409	c.3772G>A	p.E1258K	Substitution - Missense	Lung
COSM181359	c.5048G>A	p.R1683H	Substitution - Missense	Lung
COSM4717504	c.4624A>G	p.T1542A	Substitution - Missense	Large_intestine
COSM895023	c.4241C>T	p.S1414L	Substitution - Missense	Endometrium
COSM1333447	c.834A>T	p.E278D	Substitution - Missense	Large_intestine
COSM3369238	c.174A>G	p.P58P	Substitution - coding silent	Thyroid
COSM4021550	c.2782G>A	p.G928S	Substitution - Missense	Stomach
COSM1667163	c.1409C>A	p.S470Y	Substitution - Missense	Large_intestine
COSM222512	c.4421C>T	p.A1474V	Substitution - Missense	Skin
COSM4949439	c.512-1G>C	p.?	Unknown	Liver
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Small_intestine
COSM4457052	c.1030C>T	p.P344S	Substitution - Missense	Skin
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM1333446	c.832_834delGAA	p.E282delE	Deletion - In frame	Large_intestine
COSM5881501	c.2605C>A	p.H869N	Substitution - Missense	Breast
COSM1127426	c.1387G>A	p.A463T	Substitution - Missense	Prostate
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Large_intestine
COSM1747696	c.2637G>C	p.K879N	Substitution - Missense	Urinary_tract
COSM4021564	c.4512T>C	p.S1504S	Substitution - coding silent	Stomach
COSM3417978	c.299G>A	p.R100Q	Substitution - Missense	Large_intestine
COSM3788562	c.686A>T	p.E229V	Substitution - Missense	Urinary_tract
COSM3965773	c.2971C>G	p.P991A	Substitution - Missense	Central_nervous_system
COSM4021553	c.3046G>A	p.A1016T	Substitution - Missense	Prostate
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Upper_aerodigestive_tract
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Biliary_tract
COSM5977862	c.2875G>A	p.G959S	Substitution - Missense	Upper_aerodigestive_tract
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM5977860	c.2393C>T	p.P798L	Substitution - Missense	Upper_aerodigestive_tract
COSM1333449	c.852T>A	p.D284E	Substitution - Missense	Kidney
COSM1294868	c.403G>A	p.E135K	Substitution - Missense	Urinary_tract
COSM4883436	c.265G>C	p.D89H	Substitution - Missense	Upper_aerodigestive_tract
COSM5421042	c.2380A>T	p.T794S	Substitution - Missense	Prostate
COSM3710287	c.5074G>A	p.A1692T	Substitution - Missense	Upper_aerodigestive_tract
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Central_nervous_system
COSM3934051	c.2986C>T	p.P996S	Substitution - Missense	Oesophagus
COSM4021552	c.2977G>A	p.V993I	Substitution - Missense	Stomach
COSM5448168	c.3237C>T	p.S1079S	Substitution - coding silent	Large_intestine
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM5943424	c.2103delA	p.T702fs*10	Deletion - Frameshift	Skin
COSM3369240	c.480G>C	p.R160R	Substitution - coding silent	Thyroid
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Upper_aerodigestive_tract
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Stomach
COSM895003	c.773C>T	p.A258V	Substitution - Missense	Endometrium
COSM5518112	c.1228C>T	p.R410W	Substitution - Missense	Biliary_tract
COSM2230161	c.4551A>G	p.T1517T	Substitution - coding silent	Large_intestine
COSM4717496	c.1362C>G	p.D454E	Substitution - Missense	Large_intestine
COSM5660382	c.3629A>T	p.Q1210L	Substitution - Missense	Soft_tissue
COSM5968785	c.4845A>G	p.V1615V	Substitution - coding silent	Upper_aerodigestive_tract
COSM3976012	c.121C>G	p.R41G	Substitution - Missense	Lung
COSM4842117	c.3328C>G	p.L1110V	Substitution - Missense	Cervix
COSM895006	c.1415T>G	p.V472G	Substitution - Missense	Endometrium
COSM5700296	c.2146C>T	p.P716S	Substitution - Missense	Soft_tissue
COSM1626374	c.3564G>T	p.G1188G	Substitution - coding silent	Liver
COSM3472832	c.4332C>T	p.A1444A	Substitution - coding silent	Skin
COSM3862514	c.1930C>T	p.P644S	Substitution - Missense	Skin
COSM3788564	c.3194C>G	p.S1065C	Substitution - Missense	Urinary_tract
COSM414126	c.2996C>A	p.S999Y	Substitution - Missense	Urinary_tract
COSM4460544	c.1170C>T	p.F390F	Substitution - coding silent	Skin
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Stomach
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM145807	c.3502G>A	p.V1168M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM365947	c.2392C>T	p.P798S	Substitution - Missense	Lung
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM3472828	c.3104C>T	p.P1035L	Substitution - Missense	Skin
COSM3862512	c.883G>A	p.E295K	Substitution - Missense	Skin
COSM4021549	c.2621C>T	p.T874M	Substitution - Missense	Stomach
COSM1333450	c.2248C>A	p.L750I	Substitution - Missense	Large_intestine
COSM895008	c.1627G>T	p.E543*	Substitution - Nonsense	Endometrium
COSM3704898	c.199T>A	p.S67T	Substitution - Missense	Liver
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Stomach
COSM895005	c.1229G>A	p.R410Q	Substitution - Missense	Endometrium
COSM3750308	c.1008G>A	p.E336E	Substitution - coding silent	Large_intestine
COSM895024	c.4420G>A	p.A1474T	Substitution - Missense	Endometrium
COSM2230157	c.4459_4460delAA	p.K1489fs*6	Deletion - Frameshift	Skin
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM1472509	c.831_832insGAA	p.E282_D283insE	Insertion - In frame	Central_nervous_system
COSM895027	c.4919A>C	p.K1640T	Substitution - Missense	Endometrium
COSM5577677	c.1536C>T	p.P512P	Substitution - coding silent	Skin
COSM4219256	c.2110G>C	p.A704P	Substitution - Missense	Large_intestine
COSM4960785	c.4197G>A	p.Q1399Q	Substitution - coding silent	Liver
COSM3385119	c.1711G>A	p.D571N	Substitution - Missense	Pancreas
COSM1687032	c.4598A>G	p.K1533R	Substitution - Missense	Skin
COSM1221886	c.127G>A	p.G43S	Substitution - Missense	Large_intestine
COSM4142421	c.3853C>G	p.P1285A	Substitution - Missense	Thyroid
COSM2230114	c.2508T>C	p.G836G	Substitution - coding silent	Large_intestine
COSM5423507	c.1859T>C	p.V620A	Substitution - Missense	Prostate
COSM1166773	c.849_850delTG	p.D283fs*2	Deletion - Frameshift	Large_intestine
COSM3750310	c.4824A>G	p.S1608S	Substitution - coding silent	Oesophagus
COSM5654617	c.466C>T	p.R156*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1166773	c.849_850delTG	p.D283fs*2	Deletion - Frameshift	Large_intestine
COSM3704900	c.1681A>T	p.N561Y	Substitution - Missense	Liver
COSM895014	c.2533G>A	p.E845K	Substitution - Missense	Endometrium
COSM1333461	c.4423G>A	p.A1475T	Substitution - Missense	Large_intestine
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM3737469	c.4239G>C	p.S1413S	Substitution - coding silent	Soft_tissue
COSM3472831	c.4300C>T	p.L1434F	Substitution - Missense	Skin
COSM895019	c.3238G>A	p.A1080T	Substitution - Missense	Endometrium
COSM4717494	c.190delA	p.R66fs*37	Deletion - Frameshift	Large_intestine
COSM4610839	c.852delT	p.D284fs*22	Deletion - Frameshift	Large_intestine
COSM674890	c.1042G>C	p.E348Q	Substitution - Missense	Lung
COSM391655	c.2445_2452delTAGCAGTG	p.S816fs*17	Deletion - Frameshift	Lung
COSM4021565	c.4631T>C	p.V1544A	Substitution - Missense	Stomach
COSM241241	c.3832T>A	p.S1278T	Substitution - Missense	Prostate
COSM4556251	c.684G>A	p.Q228Q	Substitution - coding silent	Skin
COSM3376679	c.2622G>A	p.T874T	Substitution - coding silent	Pancreas
COSM5770600	c.1696T>G	p.L566V	Substitution - Missense	Breast
COSM4745683	c.3559G>C	p.V1187L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1294869	c.904G>A	p.E302K	Substitution - Missense	Urinary_tract
COSM4929886	c.1516C>T	p.H506Y	Substitution - Missense	Liver
COSM3472815	c.47C>T	p.A16V	Substitution - Missense	Stomach
COSM1720118	c.721A>G	p.T241A	Substitution - Missense	Skin
COSM4517941	c.470_471CC>TT	p.A157V	Substitution - Missense	Skin
COSM3725138	c.4831C>T	p.L1611L	Substitution - coding silent	Lung
COSM5352889	c.2961T>C	p.P987P	Substitution - coding silent	Large_intestine
COSM1221887	c.831T>A	p.D277E	Substitution - Missense	Soft_tissue
COSM1333447	c.834A>T	p.E278D	Substitution - Missense	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Stomach
COSM3472819	c.681C>T	p.L227L	Substitution - coding silent	Skin
COSM1600689	c.4324C>T	p.Q1442*	Substitution - Nonsense	Liver
COSM895004	c.1227G>A	p.E409E	Substitution - coding silent	Endometrium
COSM895012	c.2337C>T	p.S779S	Substitution - coding silent	Endometrium
COSM4021555	c.3792T>C	p.D1264D	Substitution - coding silent	Stomach
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM4964469	c.1999C>T	p.L667F	Substitution - Missense	Pancreas
COSM895016	c.3045C>A	p.T1015T	Substitution - coding silent	Endometrium
COSM4924898	c.3948A>T	p.T1316T	Substitution - coding silent	Liver
COSM3376679	c.2622G>A	p.T874T	Substitution - coding silent	Pancreas
COSM4772789	c.3763A>G	p.T1255A	Substitution - Missense	Stomach
COSM4021559	c.4108C>G	p.P1370A	Substitution - Missense	Stomach
COSM4021563	c.4311C>T	p.N1437N	Substitution - coding silent	Stomach
COSM4610839	c.852delT	p.D284fs*22	Deletion - Frameshift	Large_intestine
COSM5034319	c.3900A>C	p.P1300P	Substitution - coding silent	Skin
COSM1168634	c.5010C>T	p.S1670S	Substitution - coding silent	Pancreas
COSM4516380	c.1855_1856CC>TT	p.P619F	Substitution - Missense	Skin
COSM3472827	c.2954C>T	p.P985L	Substitution - Missense	Stomach
COSM423661	c.1887G>A	p.L629L	Substitution - coding silent	Breast
COSM5049373	c.656C>T	p.S219L	Substitution - Missense	Oesophagus
COSM4021544	c.1514T>C	p.V505A	Substitution - Missense	Stomach
COSM5001343	c.1414G>A	p.V472I	Substitution - Missense	Pancreas
COSM4717497	c.1493T>C	p.M498T	Substitution - Missense	Large_intestine
COSM1239927	c.4910T>C	p.F1637S	Substitution - Missense	Oesophagus
COSM4543474	c.3382G>A	p.E1128K	Substitution - Missense	Skin
COSM4475618	c.2002C>T	p.P668S	Substitution - Missense	Skin
COSM1221887	c.831T>A	p.D277E	Substitution - Missense	Large_intestine
COSM5434499	c.2642G>C	p.R881T	Substitution - Missense	Oesophagus
COSM674884	c.4983G>C	p.L1661F	Substitution - Missense	Lung
COSM5047428	c.3343G>C	p.E1115Q	Substitution - Missense	Oesophagus
COSM4836377	c.3127G>T	p.A1043S	Substitution - Missense	Cervix
COSM2230143	c.3813G>A	p.T1271T	Substitution - coding silent	Large_intestine
COSM895022	c.4183C>T	p.R1395*	Substitution - Nonsense	Endometrium
COSM3750310	c.4824A>G	p.S1608S	Substitution - coding silent	Large_intestine
COSM267252	c.2726G>T	p.G909V	Substitution - Missense	Large_intestine
COSM5367553	c.2955_2956insC	p.P988fs*102	Insertion - Frameshift	Large_intestine
COSM5792694	c.1083G>A	p.P361P	Substitution - coding silent	Upper_aerodigestive_tract
COSM1665712	c.4618delG	p.G1540fs*24	Deletion - Frameshift	Kidney
COSM1626375	c.4458_4459insA	p.V1490fs*6	Insertion - Frameshift	Liver
COSM5021263	c.5118A>G	p.P1706P	Substitution - coding silent	Bone
COSM4717499	c.2046G>T	p.E682D	Substitution - Missense	Large_intestine
COSM1333464	c.4936delG	p.P1648fs*14	Deletion - Frameshift	Large_intestine
COSM3801561	c.3057A>C	p.P1019P	Substitution - coding silent	Breast
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM2230183	c.5095C>T	p.Q1699*	Substitution - Nonsense	Large_intestine
COSM1725670	c.384G>T	p.K128N	Substitution - Missense	Liver
COSM4960785	c.4197G>A	p.Q1399Q	Substitution - coding silent	Liver
COSM5353466	c.4886C>T	p.A1629V	Substitution - Missense	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM1333461	c.4423G>A	p.A1475T	Substitution - Missense	Large_intestine
COSM4021545	c.1564G>C	p.E522Q	Substitution - Missense	Stomach
COSM895018	c.3173C>A	p.S1058Y	Substitution - Missense	Endometrium
COSM2230146	c.4066G>A	p.A1356T	Substitution - Missense	Large_intestine
COSM1166773	c.849_850delTG	p.D283fs*2	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3417981	c.5059C>T	p.R1687*	Substitution - Nonsense	Large_intestine
COSM1287367	c.980C>A	p.S327*	Substitution - Nonsense	Autonomic_ganglia
COSM1166773	c.849_850delTG	p.D283fs*2	Deletion - Frameshift	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM4021556	c.3995C>T	p.A1332V	Substitution - Missense	Stomach
COSM5641406	c.4234A>G	p.M1412V	Substitution - Missense	Oesophagus
COSM895000	c.121C>T	p.R41W	Substitution - Missense	Endometrium
COSM4004759	c.3225A>C	p.P1075P	Substitution - coding silent	Ovary
COSM1600688	c.1794A>G	p.I598M	Substitution - Missense	Liver
COSM181360	c.5055G>A	p.A1685A	Substitution - coding silent	Stomach
COSM4970529	c.849T>A	p.D283E	Substitution - Missense	Central_nervous_system
COSM895013	c.2390C>A	p.P797H	Substitution - Missense	Endometrium
COSM895025	c.4686G>A	p.S1562S	Substitution - coding silent	Endometrium
COSM1600688	c.1794A>G	p.I598M	Substitution - Missense	Liver
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Central_nervous_system
COSM4021542	c.1217G>A	p.R406Q	Substitution - Missense	Stomach
COSM5889577	c.2899C>T	p.P967S	Substitution - Missense	Skin
COSM4880242	c.2302C>T	p.L768L	Substitution - coding silent	Prostate
COSM4777829	c.1476_1477insT	p.G493fs*5	Insertion - Frameshift	Prostate
COSM3676771	c.4357T>C	p.S1453P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM5557389	c.1837A>G	p.I613V	Substitution - Missense	Prostate
COSM241242	c.4444C>T	p.P1482S	Substitution - Missense	Prostate
COSM4021558	c.4049A>G	p.K1350R	Substitution - Missense	Stomach
COSM5735259	c.32C>T	p.A11V	Substitution - Missense	Small_intestine
COSM4717501	c.2714A>C	p.N905T	Substitution - Missense	Large_intestine
COSM674889	c.1221A>C	p.R407R	Substitution - coding silent	Stomach
COSM3472823	c.2690A>T	p.N897I	Substitution - Missense	Skin
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM5448170	c.4095G>A	p.T1365T	Substitution - coding silent	Large_intestine
COSM1333454	c.2862C>A	p.P954P	Substitution - coding silent	Large_intestine
COSM5017959	c.2438C>T	p.S813F	Substitution - Missense	Soft_tissue
COSM895011	c.2240G>T	p.S747I	Substitution - Missense	Endometrium
COSM895021	c.3850G>T	p.D1284Y	Substitution - Missense	Endometrium
COSM5960899	c.4092C>G	p.Y1364*	Substitution - Nonsense	Breast
COSM4717505	c.4891_4893delAAG	p.K1632delK	Deletion - In frame	Large_intestine
COSM4576211	c.1801C>T	p.L601L	Substitution - coding silent	Bone
COSM4021543	c.1498C>T	p.R500W	Substitution - Missense	Stomach
COSM3984155	c.265G>T	p.D89Y	Substitution - Missense	Kidney
COSM252734	c.1519G>A	p.E507K	Substitution - Missense	Ovary
COSM3750310	c.4824A>G	p.S1608S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Large_intestine
COSM297202	c.4459delA	p.V1490fs*74	Deletion - Frameshift	Stomach
COSM3472827	c.2954C>T	p.P985L	Substitution - Missense	Skin
COSM2230150	c.4323G>T	p.K1441N	Substitution - Missense	Large_intestine
COSM4426175	c.3623A>G	p.Q1208R	Substitution - Missense	Oesophagus
COSM5965175	c.3707A>G	p.D1236G	Substitution - Missense	Breast
COSM4824594	c.1143C>T	p.I381I	Substitution - coding silent	Cervix
COSM5468592	c.2497A>G	p.K833E	Substitution - Missense	Large_intestine
COSM5977857	c.159_160insA	p.F56fs*7	Insertion - Frameshift	Upper_aerodigestive_tract
COSM1626374	c.3564G>T	p.G1188G	Substitution - coding silent	Large_intestine
COSM1221890	c.1220G>A	p.R407Q	Substitution - Missense	Large_intestine
COSM5928155	c.5093G>A	p.R1698K	Substitution - Missense	Skin
COSM3788563	c.3158C>T	p.S1053F	Substitution - Missense	Urinary_tract
COSM2230149	c.4146C>T	p.G1382G	Substitution - coding silent	Stomach
COSM674886	c.4239G>A	p.S1413S	Substitution - coding silent	Lung
COSM3472829	c.3186T>G	p.S1062S	Substitution - coding silent	Skin
COSM4021548	c.2411A>C	p.K804T	Substitution - Missense	Stomach
COSM5046139	c.2017A>G	p.T673A	Substitution - Missense	Oesophagus
COSM3704900	c.1681A>T	p.N561Y	Substitution - Missense	Liver
COSM1333459	c.4270delA	p.N1426fs*3	Deletion - Frameshift	Large_intestine
COSM1741198	c.849_850insAGA	p.D283_D284insR	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM4792958	c.682C>A	p.Q228K	Substitution - Missense	Liver
COSM674887	c.3595G>C	p.E1199Q	Substitution - Missense	Lung
COSM1745535	c.3670_3671insTTGAAAGC	p.G1227fs*6	Insertion - Frameshift	Urinary_tract
COSM5621599	c.763C>T	p.R255*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5673352	c.1141A>C	p.I381L	Substitution - Missense	Soft_tissue
COSM1333462	c.4665G>A	p.Q1555Q	Substitution - coding silent	Large_intestine
COSM3737469	c.4239G>C	p.S1413S	Substitution - coding silent	Soft_tissue
COSM1262952	c.3615T>G	p.N1205K	Substitution - Missense	Oesophagus
COSM3801563	c.4396T>C	p.Y1466H	Substitution - Missense	Breast
COSM3472821	c.2344C>T	p.P782S	Substitution - Missense	Skin
COSM181348	c.846A>T	p.E282D	Substitution - Missense	Large_intestine
COSM4021557	c.4020A>G	p.K1340K	Substitution - coding silent	Stomach
COSM4954343	c.143A>C	p.K48T	Substitution - Missense	Liver
COSM4922793	c.798G>T	p.L266F	Substitution - Missense	Liver
COSM4219256	c.2110G>C	p.A704P	Substitution - Missense	Oesophagus
COSM3472826	c.2865C>T	p.S955S	Substitution - coding silent	Skin
COSM4717498	c.1910A>G	p.K637R	Substitution - Missense	Large_intestine
COSM895007	c.1497A>G	p.R499R	Substitution - coding silent	Endometrium
COSM4021553	c.3046G>A	p.A1016T	Substitution - Missense	Stomach
COSM4651933	c.3093C>T	p.P1031P	Substitution - coding silent	Large_intestine
COSM112121	c.2104_2105insCTC	p.P703_A704insP	Insertion - In frame	Upper_aerodigestive_tract
COSM1168634	c.5010C>T	p.S1670S	Substitution - coding silent	Biliary_tract
COSM4954343	c.143A>C	p.K48T	Substitution - Missense	Liver
COSM5680278	c.4950C>A	p.T1650T	Substitution - coding silent	Soft_tissue
COSM3676772	c.4401T>G	p.I1467M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4832061	c.4083G>C	p.K1361N	Substitution - Missense	Cervix
COSM3472822	c.2388C>T	p.S796S	Substitution - coding silent	Skin
COSM1221889	c.4567A>C	p.K1523Q	Substitution - Missense	Large_intestine
COSM3984157	c.4546C>T	p.R1516W	Substitution - Missense	Kidney
COSM4717506	c.4943C>A	p.P1648Q	Substitution - Missense	Large_intestine
COSM4790119	c.436C>A	p.P146T	Substitution - Missense	Liver
COSM4790119	c.436C>A	p.P146T	Substitution - Missense	Liver
COSM1262953	c.1225G>T	p.E409*	Substitution - Nonsense	Oesophagus
COSM3472815	c.47C>T	p.A16V	Substitution - Missense	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
24755471	Mutation	Colorectal Carcinoma	Notably, we found that exome mutation and DNA copy-number spectra in colorectal cancer cell lines closely resembled those seen in primary colorectal tumors. Similarities included the presence of two hypermutation phenotypes, as defined by signatures for defective DNA mismatch repair and DNA polymerase ε proofreading deficiency, along with concordant mutation profiles in the broadly altered WNT, MAPK, PI3K, TGFβ, and p53 pathways. Furthermore, we documented mutations enriched in genes involved in chromatin remodeling (ARID1A, CHD6, and SRCAP) and histone methylation or acetylation (ASH1L, EP300, EP400, MLL2, MLL3, PRDM2, and TRRAP).
22993552	Hypermethylation; Mutation	Cholangiocarcinoma	An understanding of the molecular mechanisms underlying the carcinogenesis and pathogenesis of CCA is necessary to improve patient survival. Therefore, we determined the genetic and epigenetic alterations of RIZ1 in 81 CCA samples and 69 matched non-tumor tissues. Methylation was found in 31 of 81 (38%) tumor samples and in 5 of 69 (7%) matched non-tumor tissues. Frameshift mutations (2 of 81) and loss of heterozygosity (LOH) (14 of 81) were not common.
16421660	Mutation	Hereditary Nonpolyposis Colorectal Cancer	Mutations of the hMSH3, TCF4, CASP5, RIZ, RAD50, and MBD4 genes were comparatively frequent (>35 percent) in all stages.
15309726	Mutation	Gastric Carcinoma	Frameshift mutations of RIZ may play an important role in gastric cancers with MSI.
14534544	Mutation	Gastric Carcinoma	In this study, we evaluated RIZ1 in 30 primary gastric cancers and found frameshift mutations in two cases (6.7%).
12082534	Mutation	Melanoma	Frameshift mutations in the RIZ gene were found in 17% of melanoma samples and 8.6% of naevi, but we could not demonstrate any missense mutations in the exons of RIZ1.
11544182	Mutation	diffuse large B-cell Lymphoma	Finally, several missense mutations of RIZ1 were found in human tumor tissues and cell lines; one of these was particularly common in human DLBL tumors. These missense mutations, as well as the previously described frameshift mutation, all mapped to the MTase functional domains.
11135439	Mutation	Pancreatic Carcinoma; Gastric Carcinoma; Colorectal Carcinoma	In this study, we examined mutations of two poly adenine tracts, A(8) and A(9), within the coding region of the RIZ gene, in MSI-high (MSI-H) primary cancers occurring in the pancreas, stomach, and colorectum. Frameshift mutations were found in one (10%) of 10 pancreatic, four (36%) of 11 gastric, and two (25%) of eight colorectal cancers.
10987271	Mutation; Loss of Expression	Gastric Carcinoma; Endometrial Carcinomaertrial carcinoma; Colorectal Carcinoma	Frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas, 6 (33%) of 18 endometrial carcinomas, 14 (26%) of 51 of colorectal carcinomas, and 7 (54%) of 13 cell lines. Eleven tumor tissues showed biallelic inactivation of RIZ.
10688904	Mutation; Underexpression; Loss of Expression	Colorectal Carcinoma	Four of eleven microsatellite-unstable colorectal cancer cell lines, three of which had frameshifts, showed reduced or absent mRNA expression of RIZ1.

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13029	643	S	Phosphoserine	-	No	None detected
Q13029	743	S	Phosphoserine	-	No	None detected
Q13029	781	S	Phosphoserine	-	No	None detected
Q13029	785	S	Phosphoserine	-	No	None detected
Q13029	796	S	Phosphoserine	-	No	None detected

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.163	5.73	-0.535	0.000157	NS
BRCA	Breast invasive carcinoma	112	1100	6.461	6.017	-0.47	4.77e-18	NS
CESC	Cervical and endocervical cancers	3	306	6.07	5.576	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.586	5.305	-0.344	0.000136	NS
ESCA	Esophageal carcinoma	11	185	6.453	5.99	-0.472	0.0172	NS
GBM	Glioblastoma multiforme	5	166	7.195	5.338	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.95	5.554	-0.431	1.8e-06	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.659	5.216	-0.493	1.07e-17	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.455	4.829	-0.589	8.78e-08	Under
LAML	Acute Myeloid Leukemia	0	173	NA	7.36	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.816	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.91	3.581	-0.336	0.000128	NS
LUAD	Lung adenocarcinoma	59	517	6.079	5.756	-0.291	3.04e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	6.028	5.711	-0.32	2.11e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.083	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.712	5.538	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.506	4.911	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.1	5.787	-0.307	2.76e-06	NS
READ	Rectum adenocarcinoma	10	167	5.524	5.292	-0.256	0.194	NS
SARC	Sarcoma	2	263	5.207	5.572	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.672	5.56	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.943	5.703	-0.337	0.000572	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.477	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.691	6.084	-0.586	4.45e-19	Under
THYM	Thymoma	2	120	6.199	5.708	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.893	5.262	-0.652	5.14e-12	Under

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6
Autonomic ganglia	CHP212	5.9
Autonomic ganglia	IMR32	6.1
Autonomic ganglia	KELLY	6.9
Autonomic ganglia	KPNRTBM1	6.2
Autonomic ganglia	KPNSI9S	5.5
Autonomic ganglia	KPNYN	6.1
Autonomic ganglia	MHHNB11	6.2
Autonomic ganglia	NB1	6.3
Autonomic ganglia	NH6	6
Autonomic ganglia	SHSY5Y	6.3
Autonomic ganglia	SIMA	6.2
Autonomic ganglia	SKNAS	6.5
Autonomic ganglia	SKNBE2	6.2
Autonomic ganglia	SKNDZ	6.2
Autonomic ganglia	SKNFI	6.6
Autonomic ganglia	SKNSH	6.1
Biliary tract	HUCCT1	5.8
Biliary tract	HUH28	6.2
Biliary tract	SNU1079	5.6
Biliary tract	SNU1196	5.8
Biliary tract	SNU245	6.3
Biliary tract	SNU308	6.4
Biliary tract	SNU478	6.3
Bone	143B	6.5
Bone	A673	6.7
Bone	CADOES1	7.2
Bone	CAL78	6.8
Bone	G292CLONEA141B1	6.1
Bone	HOS	6.4
Bone	HS706T	6.2
Bone	HS737T	6
Bone	HS819T	5.9
Bone	HS821T	6.2
Bone	HS822T	5.9
Bone	HS863T	6.2
Bone	HS870T	6.1
Bone	HS888T	6.2
Bone	MG63	6.3
Bone	MHHES1	7.2
Bone	OUMS27	6.6
Bone	RDES	7.6
Bone	SJSA1	6.8
Bone	SKES1	7
Bone	SKNMC	7.1
Bone	SW1353	6.2
Bone	T173	6.2
Bone	TC71	7
Bone	U2OS	6.4
Breast	AU565	6.2
Breast	BT20	6.3
Breast	BT474	6.6
Breast	BT483	6.4
Breast	BT549	6.4
Breast	CAL120	6.4
Breast	CAL148	6.1
Breast	CAL51	6.3
Breast	CAL851	6.1
Breast	CAMA1	6.6
Breast	DU4475	6.3
Breast	EFM192A	6.2
Breast	EFM19	6.3
Breast	EVSAT	6.8
Breast	HCC1143	6
Breast	HCC1187	6.3
Breast	HCC1395	6
Breast	HCC1419	6.9
Breast	HCC1428	6.1
Breast	HCC1500	6.1
Breast	HCC1569	6.3
Breast	HCC1599	5.7
Breast	HCC1806	7
Breast	HCC1937	5.9
Breast	HCC1954	6.5
Breast	HCC202	6
Breast	HCC2157	6.9
Breast	HCC2218	5.8
Breast	HCC38	6
Breast	HCC70	6.3
Breast	HDQP1	6.5
Breast	HMC18	6.2
Breast	HS274T	6.1
Breast	HS281T	6.2
Breast	HS343T	6.3
Breast	HS578T	6.3
Breast	HS606T	6.2
Breast	HS739T	6.2
Breast	HS742T	6
Breast	JIMT1	6.1
Breast	KPL1	6.3
Breast	MCF7	6.5
Breast	MDAMB134VI	6.1
Breast	MDAMB157	7
Breast	MDAMB175VII	5.9
Breast	MDAMB231	6.3
Breast	MDAMB361	6.3
Breast	MDAMB415	6.4
Breast	MDAMB436	6
Breast	MDAMB453	6.2
Breast	MDAMB468	6.3
Breast	SKBR3	6.2
Breast	T47D	6.5
Breast	UACC812	6.3
Breast	UACC893	6
Breast	YMB1	6.5
Breast	ZR751	6.4
Breast	ZR7530	6.4
Central nervous system	1321N1	6.5
Central nervous system	42MGBA	6.6
Central nervous system	8MGBA	5.7
Central nervous system	A172	5.5
Central nervous system	AM38	5.9
Central nervous system	BECKER	6
Central nervous system	CAS1	6.3
Central nervous system	CCFSTTG1	6.2
Central nervous system	D283MED	6.1
Central nervous system	D341MED	6.4
Central nervous system	DAOY	6.9
Central nervous system	DBTRG05MG	5.7
Central nervous system	DKMG	6.2
Central nervous system	GAMG	6.4
Central nervous system	GB1	6.4
Central nervous system	GI1	6.4
Central nervous system	GMS10	6.1
Central nervous system	GOS3	6.2
Central nervous system	H4	6.2
Central nervous system	HS683	6.2
Central nervous system	KALS1	6.8
Central nervous system	KG1C	5.8
Central nervous system	KNS42	5.4
Central nervous system	KNS60	6
Central nervous system	KNS81	5.5
Central nervous system	KS1	5.7
Central nervous system	LN18	6.4
Central nervous system	LN229	6
Central nervous system	M059K	6.8
Central nervous system	MOGGCCM	6.2
Central nervous system	MOGGUVW	6.3
Central nervous system	NMCG1	5.5
Central nervous system	ONS76	6.3
Central nervous system	SF126	6.1
Central nervous system	SF295	6.3
Central nervous system	SNB19	6.6
Central nervous system	SNU1105	6.3
Central nervous system	SNU201	6
Central nervous system	SNU466	6.4
Central nervous system	SNU489	6.4
Central nervous system	SNU626	5.6
Central nervous system	SNU738	6
Central nervous system	SW1088	6.3
Central nervous system	SW1783	6.1
Central nervous system	T98G	6.3
Central nervous system	TM31	6.4
Central nervous system	U118MG	6.2
Central nervous system	U138MG	6
Central nervous system	U251MG	6
Central nervous system	U87MG	6.1
Central nervous system	YH13	6.4
Central nervous system	YKG1	6.5
Endometrium	AN3CA	6.1
Endometrium	COLO684	6.3
Endometrium	EFE184	5.8
Endometrium	EN	6.7
Endometrium	ESS1	6.1
Endometrium	HEC108	6.3
Endometrium	HEC151	5.9
Endometrium	HEC1A	6.1
Endometrium	HEC1B	5.7
Endometrium	HEC251	6.2
Endometrium	HEC265	6.1
Endometrium	HEC50B	5.9
Endometrium	HEC59	6.1
Endometrium	HEC6	6.6
Endometrium	ISHIKAWAHERAKLIO02ER	6.4
Endometrium	JHUEM1	6.7
Endometrium	JHUEM2	6.6
Endometrium	JHUEM3	6
Endometrium	KLE	6.1
Endometrium	MFE280	5.8
Endometrium	MFE296	6
Endometrium	MFE319	6.5
Endometrium	RL952	6.5
Endometrium	SNGM	6
Endometrium	SNU1077	6.8
Endometrium	SNU685	6.1
Endometrium	TEN	6.1
Haematopoietic and lymphoid	697	7
Haematopoietic and lymphoid	A3KAW	7.2
Haematopoietic and lymphoid	A4FUK	6.6
Haematopoietic and lymphoid	ALLSIL	6.4
Haematopoietic and lymphoid	AML193	6.4
Haematopoietic and lymphoid	AMO1	6.9
Haematopoietic and lymphoid	BCP1	7
Haematopoietic and lymphoid	BDCM	6.8
Haematopoietic and lymphoid	BL41	7.5
Haematopoietic and lymphoid	BL70	7.8
Haematopoietic and lymphoid	BV173	6.8
Haematopoietic and lymphoid	CA46	8.2
Haematopoietic and lymphoid	CI1	7.2
Haematopoietic and lymphoid	CMK115	7
Haematopoietic and lymphoid	CMK86	6.7
Haematopoietic and lymphoid	CMK	7.3
Haematopoietic and lymphoid	CMLT1	6.4
Haematopoietic and lymphoid	COLO775	7.1
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	7.7
Haematopoietic and lymphoid	DEL	6.3
Haematopoietic and lymphoid	DND41	6.7
Haematopoietic and lymphoid	DOHH2	8.2
Haematopoietic and lymphoid	EB1	7.7
Haematopoietic and lymphoid	EB2	7.8
Haematopoietic and lymphoid	EHEB	7.2
Haematopoietic and lymphoid	EJM	7.6
Haematopoietic and lymphoid	EM2	7.1
Haematopoietic and lymphoid	EOL1	6.6
Haematopoietic and lymphoid	F36P	6.6
Haematopoietic and lymphoid	GA10	7.5
Haematopoietic and lymphoid	GDM1	6.4
Haematopoietic and lymphoid	GRANTA519	7.2
Haematopoietic and lymphoid	HDLM2	7.2
Haematopoietic and lymphoid	HDMYZ	6.7
Haematopoietic and lymphoid	HEL9217	7.5
Haematopoietic and lymphoid	HEL	7.3
Haematopoietic and lymphoid	HH	8.2
Haematopoietic and lymphoid	HL60	7
Haematopoietic and lymphoid	HPBALL	7.1
Haematopoietic and lymphoid	HS604T	6
Haematopoietic and lymphoid	HS611T	7.4
Haematopoietic and lymphoid	HS616T	6
Haematopoietic and lymphoid	HS751T	6.2
Haematopoietic and lymphoid	HT	7
Haematopoietic and lymphoid	HTK	6.4
Haematopoietic and lymphoid	HUNS1	7.2
Haematopoietic and lymphoid	HUT102	6.8
Haematopoietic and lymphoid	HUT78	7.9
Haematopoietic and lymphoid	JEKO1	7.2
Haematopoietic and lymphoid	JK1	6.5
Haematopoietic and lymphoid	JM1	7.1
Haematopoietic and lymphoid	JURKAT	6.8
Haematopoietic and lymphoid	JURLMK1	6.8
Haematopoietic and lymphoid	JVM2	8.2
Haematopoietic and lymphoid	JVM3	7.5
Haematopoietic and lymphoid	K562	6.3
Haematopoietic and lymphoid	KARPAS299	6.6
Haematopoietic and lymphoid	KARPAS422	6.9
Haematopoietic and lymphoid	KARPAS620	7
Haematopoietic and lymphoid	KASUMI1	7.2
Haematopoietic and lymphoid	KASUMI2	7.2
Haematopoietic and lymphoid	KASUMI6	6.6
Haematopoietic and lymphoid	KCL22	6.5
Haematopoietic and lymphoid	KE37	6.8
Haematopoietic and lymphoid	KE97	6.4
Haematopoietic and lymphoid	KG1	6.7
Haematopoietic and lymphoid	KHM1B	6.3
Haematopoietic and lymphoid	KIJK	6
Haematopoietic and lymphoid	KMH2	7
Haematopoietic and lymphoid	KMM1	7
Haematopoietic and lymphoid	KMS11	6.7
Haematopoietic and lymphoid	KMS12BM	7.3
Haematopoietic and lymphoid	KMS18	6.5
Haematopoietic and lymphoid	KMS20	7.4
Haematopoietic and lymphoid	KMS21BM	7.1
Haematopoietic and lymphoid	KMS26	7.2
Haematopoietic and lymphoid	KMS27	7
Haematopoietic and lymphoid	KMS28BM	7.2
Haematopoietic and lymphoid	KMS34	6.4
Haematopoietic and lymphoid	KO52	7.3
Haematopoietic and lymphoid	KOPN8	7.7
Haematopoietic and lymphoid	KU812	7.3
Haematopoietic and lymphoid	KYO1	6.4
Haematopoietic and lymphoid	L1236	7.6
Haematopoietic and lymphoid	L363	7.7
Haematopoietic and lymphoid	L428	6.5
Haematopoietic and lymphoid	L540	8
Haematopoietic and lymphoid	LAMA84	6.7
Haematopoietic and lymphoid	LOUCY	7.4
Haematopoietic and lymphoid	LP1	6.4
Haematopoietic and lymphoid	M07E	6.8
Haematopoietic and lymphoid	MC116	8.1
Haematopoietic and lymphoid	ME1	7
Haematopoietic and lymphoid	MEC1	7.5
Haematopoietic and lymphoid	MEC2	7.5
Haematopoietic and lymphoid	MEG01	6.7
Haematopoietic and lymphoid	MHHCALL2	7.1
Haematopoietic and lymphoid	MHHCALL3	7.4
Haematopoietic and lymphoid	MHHCALL4	7.6
Haematopoietic and lymphoid	MINO	7.4
Haematopoietic and lymphoid	MJ	7
Haematopoietic and lymphoid	MM1S	7
Haematopoietic and lymphoid	MOLM13	6.5
Haematopoietic and lymphoid	MOLM16	6.9
Haematopoietic and lymphoid	MOLM6	6.9
Haematopoietic and lymphoid	MOLP2	7.7
Haematopoietic and lymphoid	MOLP8	7.6
Haematopoietic and lymphoid	MOLT13	6.9
Haematopoietic and lymphoid	MOLT16	7
Haematopoietic and lymphoid	MOLT4	6.7
Haematopoietic and lymphoid	MONOMAC1	6.2
Haematopoietic and lymphoid	MONOMAC6	6.5
Haematopoietic and lymphoid	MOTN1	7.8
Haematopoietic and lymphoid	MUTZ5	7.2
Haematopoietic and lymphoid	MV411	6.7
Haematopoietic and lymphoid	NALM19	7.1
Haematopoietic and lymphoid	NALM1	7.1
Haematopoietic and lymphoid	NALM6	6.8
Haematopoietic and lymphoid	NAMALWA	8.5
Haematopoietic and lymphoid	NB4	6.7
Haematopoietic and lymphoid	NCIH929	6.6
Haematopoietic and lymphoid	NCO2	6.3
Haematopoietic and lymphoid	NOMO1	6.1
Haematopoietic and lymphoid	NUDHL1	6.9
Haematopoietic and lymphoid	NUDUL1	7.4
Haematopoietic and lymphoid	OCIAML2	6.3
Haematopoietic and lymphoid	OCIAML3	6.2
Haematopoietic and lymphoid	OCIAML5	6.2
Haematopoietic and lymphoid	OCILY10	6.5
Haematopoietic and lymphoid	OCILY19	7.4
Haematopoietic and lymphoid	OCILY3	8
Haematopoietic and lymphoid	OCIM1	6.9
Haematopoietic and lymphoid	OPM2	6.7
Haematopoietic and lymphoid	P12ICHIKAWA	7.2
Haematopoietic and lymphoid	P31FUJ	6.3
Haematopoietic and lymphoid	P3HR1	7.6
Haematopoietic and lymphoid	PCM6	6.8
Haematopoietic and lymphoid	PEER	7.2
Haematopoietic and lymphoid	PF382	6.7
Haematopoietic and lymphoid	PFEIFFER	7
Haematopoietic and lymphoid	PL21	6.7
Haematopoietic and lymphoid	RAJI	7.9
Haematopoietic and lymphoid	RCHACV	7
Haematopoietic and lymphoid	REC1	8
Haematopoietic and lymphoid	REH	7
Haematopoietic and lymphoid	RI1	7.2
Haematopoietic and lymphoid	RL	7.2
Haematopoietic and lymphoid	RPMI8226	7.1
Haematopoietic and lymphoid	RPMI8402	6.5
Haematopoietic and lymphoid	RS411	6.9
Haematopoietic and lymphoid	SEM	6.5
Haematopoietic and lymphoid	SET2	6.8
Haematopoietic and lymphoid	SIGM5	6.3
Haematopoietic and lymphoid	SKM1	6.3
Haematopoietic and lymphoid	SKMM2	6.6
Haematopoietic and lymphoid	SR786	6.5
Haematopoietic and lymphoid	ST486	7
Haematopoietic and lymphoid	SUDHL10	7.2
Haematopoietic and lymphoid	SUDHL1	6.6
Haematopoietic and lymphoid	SUDHL4	7.8
Haematopoietic and lymphoid	SUDHL5	7.2
Haematopoietic and lymphoid	SUDHL6	8.2
Haematopoietic and lymphoid	SUDHL8	7.3
Haematopoietic and lymphoid	SUPB15	7.1
Haematopoietic and lymphoid	SUPHD1	6.7
Haematopoietic and lymphoid	SUPM2	6.6
Haematopoietic and lymphoid	SUPT11	7.2
Haematopoietic and lymphoid	SUPT1	6.5
Haematopoietic and lymphoid	TALL1	6.2
Haematopoietic and lymphoid	TF1	6.8
Haematopoietic and lymphoid	THP1	6.3
Haematopoietic and lymphoid	TO175T	6.2
Haematopoietic and lymphoid	TOLEDO	7.3
Haematopoietic and lymphoid	U266B1	8
Haematopoietic and lymphoid	U937	6.6
Haematopoietic and lymphoid	UT7	7.2
Haematopoietic and lymphoid	WSUDLCL2	8.2
Kidney	769P	5.6
Kidney	786O	6.3
Kidney	A498	5.2
Kidney	A704	6.1
Kidney	ACHN	5
Kidney	BFTC909	6.3
Kidney	CAKI1	5.8
Kidney	CAKI2	5.3
Kidney	CAL54	5.5
Kidney	KMRC1	6.1
Kidney	KMRC20	6.1
Kidney	KMRC2	5.3
Kidney	KMRC3	5.4
Kidney	OSRC2	6.1
Kidney	RCC10RGB	5.8
Kidney	SNU1272	5.5
Kidney	SNU349	5.9
Kidney	TUHR10TKB	5.9
Kidney	TUHR14TKB	5.6
Kidney	TUHR4TKB	5.8
Kidney	VMRCRCW	5.6
Kidney	VMRCRCZ	5.7
Large intestine	C2BBE1	6.1
Large intestine	CCK81	6.2
Large intestine	CL11	6.1
Large intestine	CL14	6.7
Large intestine	CL34	6.2
Large intestine	CL40	6.4
Large intestine	COLO205	6.3
Large intestine	COLO320	6.8
Large intestine	COLO678	6.5
Large intestine	CW2	6.1
Large intestine	DLD1	6.7
Large intestine	GP2D	6.4
Large intestine	HCC56	6.2
Large intestine	HCT116	5.8
Large intestine	HCT15	6.6
Large intestine	HS675T	6.2
Large intestine	HS698T	6
Large intestine	HT115	6.4
Large intestine	HT29	6
Large intestine	HT55	7
Large intestine	KM12	6
Large intestine	LOVO	5.9
Large intestine	LS1034	6.2
Large intestine	LS123	6.5
Large intestine	LS180	6.3
Large intestine	LS411N	6.1
Large intestine	LS513	6.4
Large intestine	MDST8	6.5
Large intestine	NCIH508	6.2
Large intestine	NCIH716	6.2
Large intestine	NCIH747	6.1
Large intestine	OUMS23	6.9
Large intestine	RCM1	6.1
Large intestine	RKO	6.2
Large intestine	SKCO1	6.1
Large intestine	SNU1040	6.3
Large intestine	SNU1197	6.2
Large intestine	SNU175	6.1
Large intestine	SNU283	6
Large intestine	SNU407	6.4
Large intestine	SNU503	6.2
Large intestine	SNU61	6.1
Large intestine	SNU81	6.1
Large intestine	SNUC1	6.6
Large intestine	SNUC2A	6.2
Large intestine	SNUC4	6.4
Large intestine	SNUC5	6
Large intestine	SW1116	6.7
Large intestine	SW1417	6.2
Large intestine	SW1463	6.3
Large intestine	SW403	6
Large intestine	SW480	6
Large intestine	SW48	6
Large intestine	SW620	6.2
Large intestine	SW837	6.9
Large intestine	SW948	6.1
Large intestine	T84	6.2
Liver	ALEXANDERCELLS	6.3
Liver	C3A	6.4
Liver	HEP3B217	6.1
Liver	HEPG2	5.9
Liver	HLE	5.9
Liver	HLF	6.1
Liver	HUH1	5.9
Liver	HUH6	6.5
Liver	HUH7	5.8
Liver	JHH1	6.5
Liver	JHH2	5.8
Liver	JHH4	5.8
Liver	JHH5	5.5
Liver	JHH6	6
Liver	JHH7	6.2
Liver	LI7	5.5
Liver	PLCPRF5	6.4
Liver	SKHEP1	6.1
Liver	SNU182	6.2
Liver	SNU387	6.3
Liver	SNU398	6.4
Liver	SNU423	5.7
Liver	SNU449	5.6
Liver	SNU475	6.2
Liver	SNU761	5.9
Liver	SNU878	5.6
Liver	SNU886	5.8
Lung	A549	6
Lung	ABC1	6.3
Lung	BEN	5.8
Lung	CAL12T	6
Lung	CALU1	5.6
Lung	CALU3	6.1
Lung	CALU6	6.4
Lung	CHAGOK1	6.4
Lung	COLO668	7
Lung	COLO699	6.7
Lung	CORL105	5.5
Lung	CORL23	5.5
Lung	CORL24	6.7
Lung	CORL279	6.9
Lung	CORL311	7.1
Lung	CORL47	6.6
Lung	CORL51	6.8
Lung	CORL88	6.7
Lung	CORL95	6.9
Lung	CPCN	5.9
Lung	DMS114	6.7
Lung	DMS153	6.4
Lung	DMS273	6.7
Lung	DMS454	6.7
Lung	DMS53	6.3
Lung	DMS79	7
Lung	DV90	5
Lung	EBC1	6.1
Lung	EPLC272H	6.2
Lung	HARA	5.8
Lung	HCC1171	6
Lung	HCC1195	6.3
Lung	HCC15	6.2
Lung	HCC2279	5.7
Lung	HCC2935	6.3
Lung	HCC33	6.7
Lung	HCC366	6.2
Lung	HCC4006	6.1
Lung	HCC44	6.8
Lung	HCC78	6.2
Lung	HCC827	6.1
Lung	HCC95	6.1
Lung	HLC1	5.9
Lung	HLFA	6.2
Lung	HS229T	6
Lung	HS618T	6
Lung	IALM	6.1
Lung	KNS62	5.8
Lung	LC1F	6.1
Lung	LC1SQSF	6.3
Lung	LCLC103H	6.2
Lung	LCLC97TM1	6
Lung	LK2	6.4
Lung	LOUNH91	6.4
Lung	LU65	5.8
Lung	LU99	5.8
Lung	LUDLU1	5.7
Lung	LXF289	5.9
Lung	MORCPR	6.3
Lung	NCIH1048	6.1
Lung	NCIH1092	7
Lung	NCIH1105	7.4
Lung	NCIH1155	6.2
Lung	NCIH1184	6.4
Lung	NCIH1299	6.3
Lung	NCIH1339	6.7
Lung	NCIH1341	6.6
Lung	NCIH1355	6.1
Lung	NCIH1373	5.8
Lung	NCIH1385	5.8
Lung	NCIH1395	6.2
Lung	NCIH1435	6.5
Lung	NCIH1436	6.8
Lung	NCIH1437	5.7
Lung	NCIH146	5.9
Lung	NCIH1563	5.4
Lung	NCIH1568	6.1
Lung	NCIH1573	6.6
Lung	NCIH1581	6.4
Lung	NCIH1618	6.3
Lung	NCIH1623	6.2
Lung	NCIH1648	6.1
Lung	NCIH1650	6.3
Lung	NCIH1651	5.7
Lung	NCIH1666	6.1
Lung	NCIH1693	6.8
Lung	NCIH1694	6.4
Lung	NCIH1703	6.4
Lung	NCIH1734	5.8
Lung	NCIH1755	6
Lung	NCIH1781	6.2
Lung	NCIH1792	5.8
Lung	NCIH1793	5.9
Lung	NCIH1836	6.5
Lung	NCIH1838	6
Lung	NCIH1869	6.3
Lung	NCIH1876	6.9
Lung	NCIH1915	5.9
Lung	NCIH1930	6.5
Lung	NCIH1944	5.2
Lung	NCIH1963	6.3
Lung	NCIH196	6.2
Lung	NCIH1975	5.9
Lung	NCIH2009	6.2
Lung	NCIH2023	6
Lung	NCIH2029	6.7
Lung	NCIH2030	6
Lung	NCIH2066	6.5
Lung	NCIH2081	6.5
Lung	NCIH2085	6.3
Lung	NCIH2087	6.1
Lung	NCIH209	6.1
Lung	NCIH2106	6.6
Lung	NCIH2110	6.1
Lung	NCIH211	6.7
Lung	NCIH2122	6
Lung	NCIH2126	6.5
Lung	NCIH2141	6.6
Lung	NCIH2170	6.1
Lung	NCIH2171	7.3
Lung	NCIH2172	6
Lung	NCIH2196	6.4
Lung	NCIH2227	6.8
Lung	NCIH2228	5.4
Lung	NCIH226	6
Lung	NCIH2286	6.5
Lung	NCIH2291	6.1
Lung	NCIH2342	6.5
Lung	NCIH2347	5.9
Lung	NCIH23	6.5
Lung	NCIH2405	5.5
Lung	NCIH2444	6.1
Lung	NCIH292	5.2
Lung	NCIH322	6.3
Lung	NCIH3255	6.1
Lung	NCIH358	5.8
Lung	NCIH441	6.5
Lung	NCIH446	6.8
Lung	NCIH460	6
Lung	NCIH510	7.1
Lung	NCIH520	6.7
Lung	NCIH522	6.4
Lung	NCIH524	6.5
Lung	NCIH526	6.1
Lung	NCIH596	6.3
Lung	NCIH647	6.4
Lung	NCIH650	6.3
Lung	NCIH661	6.3
Lung	NCIH69	5.5
Lung	NCIH727	6.8
Lung	NCIH810	6.4
Lung	NCIH82	6.9
Lung	NCIH838	6.6
Lung	NCIH841	6.7
Lung	NCIH854	6.6
Lung	NCIH889	6
Lung	PC14	6.2
Lung	RERFLCAD1	6.2
Lung	RERFLCAD2	6.4
Lung	RERFLCAI	6.1
Lung	RERFLCKJ	6.1
Lung	RERFLCMS	6
Lung	RERFLCSQ1	6.1
Lung	SBC5	7
Lung	SCLC21H	6.7
Lung	SHP77	6.5
Lung	SKLU1	6.1
Lung	SKMES1	6.5
Lung	SQ1	5.8
Lung	SW1271	5.7
Lung	SW1573	5.8
Lung	SW900	5.9
Lung	VMRCLCD	6.4
Lung	VMRCLCP	6
Oesophagus	COLO680N	6
Oesophagus	ECGI10	6.1
Oesophagus	KYSE140	7.2
Oesophagus	KYSE150	5.9
Oesophagus	KYSE180	6.3
Oesophagus	KYSE270	7.3
Oesophagus	KYSE30	7.3
Oesophagus	KYSE410	6.2
Oesophagus	KYSE450	6.1
Oesophagus	KYSE510	6.1
Oesophagus	KYSE520	6.4
Oesophagus	KYSE70	6.4
Oesophagus	OE19	6.2
Oesophagus	OE33	6.4
Oesophagus	TE10	6.6
Oesophagus	TE11	6.6
Oesophagus	TE14	6.1
Oesophagus	TE15	6.1
Oesophagus	TE1	6.6
Oesophagus	TE4	5.9
Oesophagus	TE5	6.1
Oesophagus	TE6	6.2
Oesophagus	TE8	6.3
Oesophagus	TE9	6.3
Oesophagus	TT	6.5
Ovary	59M	6.4
Ovary	A2780	6.6
Ovary	CAOV3	6
Ovary	CAOV4	6.7
Ovary	COLO704	6.3
Ovary	COV318	6.9
Ovary	COV362	6.1
Ovary	COV434	6.6
Ovary	COV504	6.5
Ovary	COV644	6.3
Ovary	EFO21	6
Ovary	EFO27	6.6
Ovary	ES2	5.9
Ovary	FUOV1	6.7
Ovary	HEYA8	5.9
Ovary	HS571T	6
Ovary	IGROV1	6.5
Ovary	JHOC5	6.1
Ovary	JHOM1	6
Ovary	JHOM2B	6.8
Ovary	JHOS2	6.3
Ovary	JHOS4	6.8
Ovary	KURAMOCHI	7.3
Ovary	MCAS	5.7
Ovary	NIHOVCAR3	6.7
Ovary	OAW28	6.6
Ovary	OAW42	5.8
Ovary	OC314	5.5
Ovary	OC316	5.9
Ovary	ONCODG1	7
Ovary	OV56	6
Ovary	OV7	6.3
Ovary	OV90	6.5
Ovary	OVCAR4	6.7
Ovary	OVCAR8	6
Ovary	OVISE	6
Ovary	OVK18	6.5
Ovary	OVKATE	6.6
Ovary	OVMANA	6.2
Ovary	OVSAHO	7.2
Ovary	OVTOKO	5.6
Ovary	RMGI	6.2
Ovary	RMUGS	5.9
Ovary	SKOV3	6
Ovary	SNU119	6.8
Ovary	SNU840	6.2
Ovary	SNU8	6.5
Ovary	TOV112D	6.2
Ovary	TOV21G	6
Ovary	TYKNU	6.6
Pancreas	ASPC1	6.5
Pancreas	BXPC3	6.1
Pancreas	CAPAN1	5.9
Pancreas	CAPAN2	6.5
Pancreas	CFPAC1	6.5
Pancreas	DANG	6.1
Pancreas	HPAC	6.4
Pancreas	HPAFII	5.7
Pancreas	HS766T	6.4
Pancreas	HUPT3	6.3
Pancreas	HUPT4	6.2
Pancreas	KCIMOH1	6.2
Pancreas	KLM1	6.1
Pancreas	KP2	6.9
Pancreas	KP3	5.9
Pancreas	KP4	6.2
Pancreas	L33	6.1
Pancreas	MIAPACA2	6.6
Pancreas	PANC0203	6.2
Pancreas	PANC0213	6.6
Pancreas	PANC0327	6
Pancreas	PANC0403	6
Pancreas	PANC0504	5.9
Pancreas	PANC0813	6.4
Pancreas	PANC1005	6.6
Pancreas	PANC1	6.5
Pancreas	PATU8902	5.4
Pancreas	PATU8988S	5.5
Pancreas	PATU8988T	5.5
Pancreas	PK1	5.7
Pancreas	PK45H	6
Pancreas	PK59	6.4
Pancreas	PL45	6.3
Pancreas	PSN1	5.6
Pancreas	QGP1	6.4
Pancreas	SNU213	6.4
Pancreas	SNU324	5.4
Pancreas	SNU410	6.2
Pancreas	SU8686	6.2
Pancreas	SUIT2	6.1
Pancreas	SW1990	5.7
Pancreas	T3M4	6.3
Pancreas	TCCPAN2	5.5
Pancreas	YAPC	6.8
Pleura	ACCMESO1	5.9
Pleura	DM3	5.9
Pleura	ISTMES1	6.2
Pleura	ISTMES2	6.3
Pleura	JL1	6.1
Pleura	MPP89	5.6
Pleura	MSTO211H	5.7
Pleura	NCIH2052	5.5
Pleura	NCIH2452	6.2
Pleura	NCIH28	5.7
Prostate	22RV1	5.9
Prostate	DU145	5.8
Prostate	LNCAPCLONEFGC	6.4
Prostate	MDAPCA2B	6.5
Prostate	NCIH660	6.6
Prostate	PC3	6
Prostate	VCAP	6.4
Salivary gland	A253	6.1
Salivary gland	YD15	6.1
Skin	A101D	6.2
Skin	A2058	6.2
Skin	A375	6.2
Skin	C32	6.3
Skin	CHL1	6.5
Skin	CJM	6.1
Skin	COLO679	6.7
Skin	COLO741	6.6
Skin	COLO783	6.7
Skin	COLO792	6
Skin	COLO800	6.6
Skin	COLO818	6.5
Skin	COLO829	6.4
Skin	COLO849	6
Skin	G361	6.3
Skin	GRM	5.8
Skin	HMCB	6.9
Skin	HS294T	6
Skin	HS600T	5.9
Skin	HS688AT	6.5
Skin	HS695T	6.1
Skin	HS839T	6.1
Skin	HS852T	6.6
Skin	HS895T	5.9
Skin	HS934T	6.1
Skin	HS936T	6.4
Skin	HS939T	6.3
Skin	HS940T	6.2
Skin	HS944T	6
Skin	HT144	5.6
Skin	IGR1	7.1
Skin	IGR37	6.5
Skin	IGR39	6.4
Skin	IPC298	6.5
Skin	K029AX	6.9
Skin	LOXIMVI	5.8
Skin	MALME3M	6.2
Skin	MDAMB435S	6.2
Skin	MELHO	6.4
Skin	MELJUSO	6.6
Skin	MEWO	7.3
Skin	RPMI7951	6.5
Skin	RVH421	6.2
Skin	SH4	5.9
Skin	SKMEL1	6.4
Skin	SKMEL24	6.2
Skin	SKMEL28	7.3
Skin	SKMEL2	6.5
Skin	SKMEL30	6.8
Skin	SKMEL31	6.5
Skin	SKMEL3	6.6
Skin	SKMEL5	6.3
Skin	UACC257	6.8
Skin	UACC62	6.4
Skin	WM115	6.5
Skin	WM1799	6.2
Skin	WM2664	6.2
Skin	WM793	6.5
Skin	WM88	6.5
Skin	WM983B	6.8
Small intestine	HUTU80	5.9
Soft tissue	A204	6.1
Soft tissue	G401	6.2
Soft tissue	G402	6.2
Soft tissue	GCT	6.2
Soft tissue	HS729	6.3
Soft tissue	HT1080	6
Soft tissue	KYM1	6.2
Soft tissue	MESSA	6.2
Soft tissue	RD	7
Soft tissue	RH30	6.2
Soft tissue	RH41	6.9
Soft tissue	RKN	6.3
Soft tissue	S117	7
Soft tissue	SJRH30	6.8
Soft tissue	SKLMS1	6.5
Soft tissue	SKUT1	6.2
Soft tissue	TE125T	6.1
Soft tissue	TE159T	6
Soft tissue	TE441T	6.5
Soft tissue	TE617T	6.3
Stomach	2313287	6
Stomach	AGS	6.5
Stomach	AZ521	5.9
Stomach	ECC10	6.1
Stomach	ECC12	6
Stomach	FU97	6.2
Stomach	GCIY	5.9
Stomach	GSS	6.2
Stomach	GSU	6.1
Stomach	HGC27	6.1
Stomach	HS746T	5.9
Stomach	HUG1N	6.3
Stomach	IM95	5.7
Stomach	KATOIII	6.3
Stomach	KE39	6
Stomach	LMSU	5.9
Stomach	MKN1	5.9
Stomach	MKN45	6.7
Stomach	MKN74	6.7
Stomach	MKN7	6
Stomach	NCCSTCK140	6.2
Stomach	NCIN87	6
Stomach	NUGC2	5.8
Stomach	NUGC3	5.6
Stomach	NUGC4	6
Stomach	OCUM1	6.3
Stomach	RERFGC1B	6.6
Stomach	SH10TC	5.9
Stomach	SNU16	6.7
Stomach	SNU1	6.6
Stomach	SNU216	6.5
Stomach	SNU520	5.9
Stomach	SNU5	5.8
Stomach	SNU601	6.2
Stomach	SNU620	6
Stomach	SNU668	5.8
Stomach	SNU719	6.3
Stomach	TGBC11TKB	6.5
Thyroid	8305C	6.4
Thyroid	8505C	6.4
Thyroid	BCPAP	6.7
Thyroid	BHT101	6.3
Thyroid	CAL62	6.5
Thyroid	CGTHW1	6.3
Thyroid	FTC133	6.1
Thyroid	FTC238	6.6
Thyroid	ML1	6.3
Thyroid	SW579	6.3
Thyroid	TT2609C02	5.3
Thyroid	TT	5.5
Upper aerodigestive tract	BHY	6.2
Upper aerodigestive tract	BICR16	6.1
Upper aerodigestive tract	BICR18	6.1
Upper aerodigestive tract	BICR22	6.4
Upper aerodigestive tract	BICR31	7
Upper aerodigestive tract	BICR56	6.5
Upper aerodigestive tract	BICR6	6.3
Upper aerodigestive tract	CAL27	6.3
Upper aerodigestive tract	CAL33	6.1
Upper aerodigestive tract	DETROIT562	5.9
Upper aerodigestive tract	FADU	6.1
Upper aerodigestive tract	HS840T	6.2
Upper aerodigestive tract	HSC2	6.1
Upper aerodigestive tract	HSC3	6.1
Upper aerodigestive tract	HSC4	6.1
Upper aerodigestive tract	PECAPJ15	6.6
Upper aerodigestive tract	PECAPJ34CLONEC12	6.6
Upper aerodigestive tract	PECAPJ41CLONED2	6.5
Upper aerodigestive tract	PECAPJ49	6.3
Upper aerodigestive tract	SCC15	6.5
Upper aerodigestive tract	SCC25	6.4
Upper aerodigestive tract	SCC4	6.5
Upper aerodigestive tract	SCC9	6.4
Upper aerodigestive tract	SNU1076	6.5
Upper aerodigestive tract	SNU1214	6.1
Upper aerodigestive tract	SNU46	5.7
Upper aerodigestive tract	SNU899	6
Upper aerodigestive tract	YD10B	6.5
Upper aerodigestive tract	YD38	6.6
Upper aerodigestive tract	YD8	6.1
Urinary tract	5637	6.1
Urinary tract	639V	6.3
Urinary tract	647V	6.2
Urinary tract	BC3C	6.2
Urinary tract	BFTC905	6.2
Urinary tract	CAL29	6.4
Urinary tract	HS172T	6.5
Urinary tract	HT1197	6.8
Urinary tract	HT1376	6.4
Urinary tract	J82	6.1
Urinary tract	JMSU1	6.7
Urinary tract	KMBC2	6.3
Urinary tract	KU1919	6.3
Urinary tract	RT11284	6.4
Urinary tract	RT112	6.3
Urinary tract	RT4	6.3
Urinary tract	SCABER	6.6
Urinary tract	SW1710	6.1
Urinary tract	SW780	6.8
Urinary tract	T24	6.1
Urinary tract	TCCSUP	6.3
Urinary tract	UMUC1	6
Urinary tract	UMUC3	6.2
Urinary tract	VMCUB1	6.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	18.3
Adrenal gland	19.1
Appendix	26.8
Bone marrow	51.3
Breast	21.9
Cerebral cortex	44.4
Cervix, uterine	24
Colon	12.6
Duodenum	13.4
Endometrium	30.1
Epididymis	19.6
Esophagus	22.6
Fallopian tube	21.2
Gallbladder	27
Heart muscle	10.1
Kidney	11
Liver	4.5
Lung	24.7
Lymph node	32.3
Ovary	38.4
Pancreas	2.8
Parathyroid gland	25.1
Placenta	23.8
Prostate	27.5
Rectum	15.4
Salivary gland	7.3
Seminal vesicle	24.3
Skeletal muscle	11.2
Skin	27.7
Small intestine	15.7
Smooth muscle	22.1
Spleen	26.6
Stomach	14.2
Testis	34.8
Thyroid gland	40.7
Tonsil	23.9
Urinary bladder	20.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28339081	underexpression (hypermethylation)	Hepatocellular Carcinoma	RIZ1 gene, a candidate HCC suppressor gene, is frequently found to be hypermethylated and downregulated in HCC.
26690953	Underexpression	Glioma	Real-time polymerase chain reaction and western blot analysis showed that RIZ1 was downregulated in high-grade gliomas compared with low-grade gliomas and normal brain tissue.
25987089	Underexpression (hypermethylation); Loss of Expression	Renal Cell Carcinoma	RIZ1 expression was down-regulated or lost in OS-RC-2, 769-P, Caki-1, 786-O and A498 RCC cell lines. RIZ1 expression is down-regulated in human RCC, and this down-regulation is associated with methylation.
25722013	altered expression	Parathyroid Gland Neoplasm	Impaired expression of the histone methyltransferases EZH2, BMI1, and RIZ1 have been described in parathyroid tumors.
24966940	Underexpression (hypermethylation)	Lung Carcinoma	PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells.
24441146	Overexpression	pediatric Myeloid Leukemia	Gene expression profiling showed a unique signature characterized by significantly higher expression of EYA3, SESN1, PRDM2/RIZ, and HIST2H4 genes. In conclusion, t(6;9)/DEK-NUP214 represents a unique subtype of acute myeloid leukemia with a high risk of relapse, high frequency of FLT3-ITD, and a specific gene expression signature.
24040155	altered expression	Rectal cacinoma	Twenty seven out of 35 patients were finally included in the study. We performed a multiple t-test using Significance Analysis of Microarrays, to find those genes differing significantly in expression, between responders (n=11) and non-responders (n=16) to CRT. The differently expressed genes were: BC 035656.1, CIR, PRDM2, CAPG, FALZ, HLA-DPB2, NUPL2, and ZFP36.
22614009	Underexpression	Malignant meningioma	These results from our study indicate that RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas.
22372344	Underexpression (hypermethylation)	Esophageal Squamous Cell Carcinoma	In the 28 ESCC patient samples, RIZ1 expression was significantly lower in the tumor tissues than that in their adjacent non-cancerous tissues (p < 0.05). Methylation of the RIZ1 promoter and loss of RIZ1 expression in human ESCC are independent biomarkers.
22363126	Underexpression (hypermethylation)	Esophageal Squamous Cell Carcinoma	The expression of RIZ1 mRNA in TE-13 was up-regulated after treatment with 5-aza-CdR. Promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human ESCC.
22300346	Loss of Expression (hypermethylation)	T Acute Lymphoblastic Leukemia	These results suggest that RIZ1 is inactivated in adult ALL, and this inactivation is associated with methylation in T-ALL.
21369371	Overexpression	Prostate Carcinoma	In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
20878080	Underexpression	Neuroblastoma	However, RIZ1 and RIZ1+2 mRNA were significantly under-expressed in biologically unfavourable tumors characterized by 1p loss (p<0.005) or MYCN amplification (p<0.005).
20828818	Underexpression (hypermethylation)	Acute Myeloid Leukemia	Decreased RIZ1 expression was accompanied by methylation in six of nine samples examined, while it was also observed in seven of 13 without methylation.
20675009	Loss of Expression (hypermethylation)	Hepatocellular Carcinoma	RIZ1 methylation was detected in 66.7% (32/48) HCC tissues, 6.3% (3/48) corresponding non-cancerous tissues, and 66.7% (4/6) HCC cell lines. All 32 HCC tissues with promoter methylation showed complete loss of RIZ1 protein, whereas RIZ1 protein was present in all the corresponding non-cancerous tissues.
20159667	Underexpression (hypermethylation); Loss of Expression (hypermethylation)	Cervical Carcinoma	RIZ1 expression is reduced or lost in cervical cancers, compared with normal cervical tissues (P <0.05). The current study results also showed that loss of RIZ1 is mediated by aberrant cytosine methylation of the RIZ1 promoter. RIZ1 mRNA expression was significantly higher (P = 0.000) in unmethylated (0.3494 +/- 0.0466, mean +/-SD), compared with methylated tissues (0.1422 +/- 0.1073, mean +/-SD)
19746436	Underexpression	Prostate Carcinoma	Our data demonstrate that RIZ1 is expressed in normal PECs and down-regulated in cancer cells, with a switch of its sub-cellular localization from the nucleus to the cytoplasm upon cancer grade progression.
19602237	Underexpression	Chronic Myelogenous Leukemia	RIZ1 is a candidate tumor suppressor gene whose expression is decreased in blast crisis. Loss of RIZ1 activity results in decreased apoptosis and differentiation and enhanced proliferation. Together these results suggest that loss of RIZ1 expression will lead to an increase in myeloid blast cell population resulting in CML progression.
18712668	Loss of Expression (hypermethylation)	Hepatocellular Carcinoma	These results suggest that the inactivation of the RIZ1 by DNA methylation at its promoter region is involved in the tumorigenesis of HCC, particularly in the early stage of disease.
17963297	Underexpression (hypermethylation)	Hepatocellular Carcinoma	SMYD3 over-expression in HCC was associated with RIZ1 hypermethylation and mRNA down-expression.
17922684	Underexpression (hypermethylation)	Ovarian Carcinoma	DNA methylation status of RIZ1 was also studied. All (6/6) of the normal, 5/9 of benign, and 4/9 of borderline tissues were positive for RIZ1 protein. In ovarian cancer tissues 32.9% (54/164) were positive for RIZ1. Decreased expression of RIZ1 was significantly correlated with histological subtypes (P < 0.0001), high tumor grade (P = 0.0153) and advanced clinical stage (P = 0.0345), and high Ki67 index (P = 0.0117) but was not associated with the overall prognoses of the patients (P = 0.519). The presence of methylated band was detected in 2/9 cell lines, and 5/69 ovarian cancer tissues. Median values of relative RIZ1 expression in cell lines with methylation were significantly lower than those without methylation (P = 0.0404), and treatment of 5-aza-2'deoxycitidine resulted in demethylation and re-expression of RIZ1.
17103461	Underexpression (hypermethylation); Loss of Expression (hypermethylation)	Thyroid Gland Carcinoma; Thyroid Gland Neoplasm	The authors demonstrated that RIZ1 expression is lost in thyroid tumor cell lines and is also significantly reduced in thyroid carcinomas, when compared with normal thyroid tissues (P < .0001) and benign tumors (P = .0003). The current study results also showed that loss of RIZ1 is mediated by aberrant cytosine methylation of the RIZ1 promoter. RIZ1 mRNA expression was significantly higher (P = .02) in unmethylated (1.22 +/- 1.2, mean +/- standard deviation [SD]), compared with methylated tissues (0.37 +/- 0.42, mean +/- SD).
17052263	Underexpression (hypermethylation)	Prostate Carcinoma	DNA methylation of the RIZ1 gene was detected in 20 (42.6%) of the 47 PCa tissues by methylation-specific polymerase chain reaction. Of the three PCa cell lines, only the PC3 cell line showed loss of RIZ1 mRNA due to DNA methylation, and this loss was rectified by treatment with a demethylating agent, 5-Aza-2'-deoxycytidine.
16706806	Loss of Expression (hypermethylation)	Hepatocellular Carcinoma	Frequent promoter hypermethylation and subsequent loss of protein expression has also been demonstrated in HCC at tumor suppressor gene (TSG), p16, p14, p15, SOCS1, RIZ1, E-cadherin and 14-3-3 sigma.
15809732	Underexpression	Adrenal Gland Pheochromocytoma; abdominal paraganGlioma	RIZ1 mRNA appeared to be significantly under-expressed in the tumour samples compared to normal adrenal controls (mean 0.6 vs. 1.0, p<0.001).
15069684	Underexpression (hypermethylation)	Gastric Carcinoma	Promoter hypermethylation of the RIZ1 gene was found in 31 (69%) of 45 gastric carcinoma tissues and in 3 (21%) of 14 corresponding non-neoplastic mucosae, the incidence being significantly different (p = 0.002). Promoter hypermethylation was associated with reduced RIZ1 expression in gastric carcinoma tissues (p = 0.029).
12631603	Loss of Expression (hypermethylation)	Nasopharyngeal Carcinoma	The methylated RIZ1 gene was detected in both CNE-2 and M1, 18 (60%) NP tumors, but not in any of the normal controls. Of 30 matched body fluid samples, methylated RIZ1 DNA was found in 11 (37%) NP swabs, 9 (30%) M & T rinsing fluid, 7 (23%) plasma, and 3 (10%) buffy coat samples. Sequencing analysis confirmed all cytosines to uracils conversion, excluding cytosines in CpG dinucleotides in methylated PCR products. Promoter methylation correlated with loss of RIZ1 mRNA expression, and 5-aza-2'-deoxycytidine treatment restored its expression in CNE-2.
12472571	altered expression	Leukemia; Acute Myeloid Leukemia	Our results showed that the expression of RIZ1 was significantly decreased in leukemia cell lines (14 out of 17, 82%) and in patients with acute myeloblastic leukemia (eight out of 14, 57%). In contrast, RIZ2 expression was increased in patients with acute lymphoblastic leukemia (eight out of 11, 73%), compared with normal bone marrow cells.
11719434	Underexpression (hypermethylation); Loss of Expression	Breast Carcinoma; liver carcinoma; Colon Carcinoma; Lung Carcinoma	Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
10987271	Mutation; Loss of Expression	Gastric Carcinoma; Endometrial Carcinomaertrial carcinoma; Colorectal Carcinoma	Frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas, 6 (33%) of 18 endometrial carcinomas, 14 (26%) of 51 of colorectal carcinomas, and 7 (54%) of 13 cell lines. Eleven tumor tissues showed biallelic inactivation of RIZ.
10688904	Mutation; Underexpression; Loss of Expression	Colorectal Carcinoma	Four of eleven microsatellite-unstable colorectal cancer cell lines, three of which had frameshifts, showed reduced or absent mRNA expression of RIZ1.
10508492	Underexpression	hepatoma tumor	RIZ1 expression was also decreased in hepatoma tumor specimens.

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.433	7.3e-20	18.3	61.4	20.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.477	3.8e-62	41.8	52.7	5.6	Loss
CESC	Cervical and endocervical cancers	292	0.521	9.81e-22	12.7	59.9	27.4	Neutral
COAD	Colon adenocarcinoma	449	0.367	8.43e-16	33.9	63.7	2.4	Loss
ESCA	Esophageal carcinoma	183	0.483	4.54e-12	35	47.5	17.5	Loss
GBM	Glioblastoma multiforme	147	0.552	4.04e-13	10.2	70.7	19	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.409	3.43e-22	18.1	70.8	11.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.302	1.49e-12	18.9	80	1.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.509	2e-20	18.1	81.2	0.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.053	0.499	0.6	97	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.578	4.34e-47	38	59.6	2.3	Loss
LIHC	Liver hepatocellular carcinoma	364	0.508	2.6e-25	39.3	54.7	6	Loss
LUAD	Lung adenocarcinoma	512	0.48	7.32e-31	22.9	53.5	23.6	Neutral
LUSC	Lung squamous cell carcinoma	498	0.532	8.89e-38	45.2	43.4	11.4	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.663	2.73e-39	33.7	37.3	29	Loss
PAAD	Pancreatic adenocarcinoma	177	0.598	1.55e-18	29.4	64.4	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.777	5.37e-34	62.3	37	0.6	Loss
PRAD	Prostate adenocarcinoma	491	0.309	2.52e-12	10	89.2	0.8	Neutral
READ	Rectum adenocarcinoma	164	0.521	8.33e-13	43.3	54.3	2.4	Loss
SARC	Sarcoma	255	0.501	1.31e-17	18.8	49.8	31.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.573	2.01e-33	19.9	59.1	21	Neutral
STAD	Stomach adenocarcinoma	413	0.442	3.4e-21	24.2	65.1	10.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.051	0.536	21.3	62.7	16	Neutral
THCA	Thyroid carcinoma	497	0.169	0.000148	1	98.6	0.4	Neutral
THYM	Thymoma	119	0.073	0.429	6.7	92.4	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.41	3.44e-23	12.8	78.2	8.9	Neutral

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.374	1.36e-15	17	408	-0.134	0.00288	NS/NA
BRCA	Breast invasive carcinoma	-0.342	0	83	785	0.004	6.31e-09	NS/NA
CESC	Cervical and endocervical cancers	-0.351	2.99e-10	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.349	2.37e-10	19	297	0.001	0.0199	NS/NA
ESCA	Esophageal carcinoma	-0.481	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.484	5.43e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.265	4.24e-10	20	522	0.002	0.00294	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.303	1.17e-08	24	319	0.227	5.82e-08	Increased
KIRP	Kidney renal papillary cell carcinoma	-0.362	1.67e-10	23	275	0.003	0.0545	NS/NA
LAML	Acute Myeloid Leukemia	-0.387	2.28e-07	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.412	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.348	4.33e-13	41	373	0.007	3.47e-05	NS/NA
LUAD	Lung adenocarcinoma	-0.191	2.74e-05	21	456	-0.044	0.01	NS/NA
LUSC	Lung squamous cell carcinoma	-0.337	2.38e-11	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.733	0.0311	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.441	6.02e-10	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.453	1.09e-10	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.344	3.45e-16	35	498	0.002	0.343	NS/NA
READ	Rectum adenocarcinoma	-0.488	3.21e-07	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.346	1.03e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.287	2.43e-10	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.341	1.95e-11	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.556	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.149	0.000399	50	509	0.018	0.00134	NS/NA
THYM	Thymoma	-0.446	3.49e-07	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.195	2.35e-05	34	431	0	0.336	NS/NA

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	1	Low
Breast	2	Medium
Bronchus	1	Low
Caudate	3	High
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	1	Low
Colon	1	Low
Duodenum	1	Low
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	1	Low
Gallbladder	1	Low
Heart muscle	1	Low
Hippocampus	3	High
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	1	Low
Placenta	2	Medium
Prostate	1	Low
Rectum	1	Low
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	1	Low
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	0	Not detected

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.704	NS	24476821
BRCA	Breast invasive carcinoma	521	4.31e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000995	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0215	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.57e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0194	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.42e-30	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.95e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.336	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0399	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000134	Significant	26544944
READ	Rectum adenocarcinoma	67	0.131	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00281	Significant	26091043
STAD	Stomach adenocarcinoma	277	8.94e-13	Significant	25079317
THCA	Thyroid carcinoma	391	0.251	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.361	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.724	0.131	NS
BRCA	Breast invasive carcinoma	1079	1.119	0.621	NS
CESC	Cervical and endocervical cancers	291	1.436	0.289	NS
COAD	Colon adenocarcinoma	439	0.987	0.968	NS
ESCA	Esophageal carcinoma	184	0.669	0.242	NS
GBM	Glioblastoma multiforme	158	0.884	0.624	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.56	0.00271	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.93	0.745	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.299	0.0146	Longer
LAML	Acute Myeloid Leukemia	149	1.032	0.892	NS
LGG	Brain Lower Grade Glioma	511	1.263	0.395	NS
LIHC	Liver hepatocellular carcinoma	365	0.764	0.272	NS
LUAD	Lung adenocarcinoma	502	0.483	0.00101	Longer
LUSC	Lung squamous cell carcinoma	494	1.138	0.525	NS
OV	Ovarian serous cystadenocarcinoma	303	1.282	0.246	NS
PAAD	Pancreatic adenocarcinoma	177	0.921	0.793	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.601	0.424	NS
PRAD	Prostate adenocarcinoma	497	0.385	0.394	NS
READ	Rectum adenocarcinoma	159	0.722	0.546	NS
SARC	Sarcoma	259	1.349	0.309	NS
SKCM	Skin Cutaneous Melanoma	459	1.109	0.59	NS
STAD	Stomach adenocarcinoma	388	1.095	0.687	NS
TGCT	Testicular Germ Cell Tumors	134	0.653	0.728	NS
THCA	Thyroid carcinoma	500	2.478	0.262	NS
THYM	Thymoma	119	1.156	0.885	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.052	0.00891	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.057	0.256	NS
BRCA	Breast invasive carcinoma	1071	-0.058	0.0564	NS
CESC	Cervical and endocervical cancers	167	0.006	0.934	NS
COAD	Colon adenocarcinoma	445	-0.006	0.895	NS
ESCA	Esophageal carcinoma	162	-0.026	0.741	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.062	0.192	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.071	0.104	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.247	5.8e-05	Lower
LIHC	Liver hepatocellular carcinoma	347	0.086	0.109	NS
LUAD	Lung adenocarcinoma	507	-0.141	0.00149	Lower
LUSC	Lung squamous cell carcinoma	497	-0.056	0.21	NS
OV	Ovarian serous cystadenocarcinoma	302	0.091	0.114	NS
PAAD	Pancreatic adenocarcinoma	176	0.181	0.0163	Higher
READ	Rectum adenocarcinoma	156	0.012	0.885	NS
SKCM	Skin Cutaneous Melanoma	410	0.006	0.91	NS
STAD	Stomach adenocarcinoma	392	0.032	0.521	NS
TGCT	Testicular Germ Cell Tumors	81	-0.438	4.36e-05	Lower
THCA	Thyroid carcinoma	499	-0.065	0.145	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.018	0.696	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.115	0.0578	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.001	0.98	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.064	0.141	NS
LGG	Brain Lower Grade Glioma	514	-0.03	0.49	NS
LIHC	Liver hepatocellular carcinoma	366	-0.053	0.313	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.075	0.198	NS
PAAD	Pancreatic adenocarcinoma	176	-0.022	0.774	NS
STAD	Stomach adenocarcinoma	406	0.114	0.0214	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.118	0.00654	Higher

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PRDM2.

Summary
Symbol	PRDM2
Name	PR/SET domain 2
Aliases	RIZ; RIZ1; RIZ2; KMT8; MTB-ZF; HUMHOXY1; retinoblastoma protein-binding zinc finger protein; retinoblastoma ......
Location	1p36.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28339081	Hepatocellular Carcinoma	upstream	DNMT1; HBx	negative regulation	HBx recombinant transfection increased DNMT1 expression level and suppressed RIZ1 expression. Moreover, knockdown of DNMT1 by siRNA restored RIZ1 expression in HCC cell SMMC-7721 and reduced methylated CpG sites of RIZ1.
26690953	Glioma	partner	Ki-67	Negative correlation	There was a negative correlation between RIZ1 and Ki-67 immunoreactivity.
22614009	Malignant meningioma	partner	c-myc	Negative correlation	Furthermore, RIZ1 overexpression in malignant meningioma cells was associated with the downregulation of c-myc expression.
17963297	Hepatocellular Carcinoma	partner	SMYD3	Negative correlation	SMYD3 over-expression in HCC was associated with RIZ1 hypermethylation and mRNA down-expression.
17052263	Prostate Carcinoma	partner	p53	Association	All four PCa specimens with nuclear accumulation of p53 were stage III disease and showed DNA methylation of RIZ1.
10688904	Colorectal Carcinoma	upstream	p1	Regulation	We propose that RIZ is a target of the observed 1p alterations, with impairment of the PR domain-mediated function through either frameshift mutation or genomic deletion.