CR2Cancer

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

Function

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H4R3	H4R3me1, H4R3me2a	11387442

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0002262 myeloid cell homeostasis GO:0002683 negative regulation of immune system process GO:0006479 protein methylation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0008213 protein alkylation GO:0010948 negative regulation of cell cycle process GO:0016570 histone modification GO:0016571 histone methylation GO:0018195 peptidyl-arginine modification GO:0018216 peptidyl-arginine methylation GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0020027 hemoglobin metabolic process GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte differentiation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031098 stress-activated protein kinase signaling cascade GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0032259 methylation GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0034101 erythrocyte homeostasis GO:0034969 histone arginine methylation GO:0035246 peptidyl-arginine N-methylation GO:0035247 peptidyl-arginine omega-N-methylation GO:0038066 p38MAPK cascade GO:0042541 hemoglobin biosynthetic process GO:0042770 signal transduction in response to DNA damage GO:0043410 positive regulation of MAPK cascade GO:0043414 macromolecule methylation GO:0043985 histone H4-R3 methylation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045652 regulation of megakaryocyte differentiation GO:0045653 negative regulation of megakaryocyte differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046984 regulation of hemoglobin biosynthetic process GO:0046985 positive regulation of hemoglobin biosynthetic process GO:0048872 homeostasis of number of cells GO:0051403 stress-activated MAPK cascade GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:1900744 regulation of p38MAPK cascade GO:1900745 positive regulation of p38MAPK cascade GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Molecular Function	GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008327 methyl-CpG binding GO:0008469 histone-arginine N-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016273 arginine N-methyltransferase activity GO:0016274 protein-arginine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0042054 histone methyltransferase activity GO:0044020 histone methyltransferase activity (H4-R3 specific) GO:0048273 mitogen-activated protein kinase p38 binding GO:0051019 mitogen-activated protein kinase binding
Cellular Component	GO:0034708 methyltransferase complex GO:0034709 methylosome

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04068 FoxO signaling pathway hsa04922 Glucagon signaling pathway
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214858: RMTs methylate histone arginines R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-3700989: Transcriptional Regulation by TP53

> KEGG and Reactome Pathway

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KEGG

hsa04068 FoxO signaling pathway
hsa04922 Glucagon signaling pathway

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM118842	c.873G>A	p.T291T	Substitution - coding silent	Stomach
COSM5701091	c.848_849insC	p.Y285fs*>64	Insertion - Frameshift	Soft_tissue
COSM5150343	c.824C>T	p.T275I	Substitution - Missense	Large_intestine
COSM5550594	c.305C>T	p.A102V	Substitution - Missense	Prostate
COSM2753100	c.1008C>T	p.C336C	Substitution - coding silent	Prostate
COSM2753097	c.769G>A	p.V257M	Substitution - Missense	Large_intestine
COSM5056833	c.699C>A	p.I233I	Substitution - coding silent	Stomach
COSM5936518	c.736C>T	p.P246S	Substitution - Missense	Skin
COSM5511103	c.486G>A	p.A162A	Substitution - coding silent	Biliary_tract
COSM475042	c.940C>T	p.R314W	Substitution - Missense	Prostate
COSM1395308	c.464A>G	p.Y155C	Substitution - Missense	Large_intestine
COSM999378	c.913G>A	p.E305K	Substitution - Missense	Endometrium
COSM1290994	c.621C>T	p.A207A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4080149	c.825C>T	p.T275T	Substitution - coding silent	Stomach
COSM3536907	c.850C>T	p.P284S	Substitution - Missense	Skin
COSM5123126	c.572-4C>A	p.?	Unknown	Large_intestine
COSM999376	c.699C>G	p.I233M	Substitution - Missense	Endometrium
COSM3693312	c.512G>A	p.R171Q	Substitution - Missense	Large_intestine
COSM3893061	c.567C>T	p.I189I	Substitution - coding silent	Skin
COSM4080147	c.757C>T	p.R253W	Substitution - Missense	Stomach
COSM5697036	c.839-2A>T	p.?	Unknown	Soft_tissue
COSM2753081	c.143G>A	p.R48H	Substitution - Missense	Stomach
COSM367225	c.903G>A	p.V301V	Substitution - coding silent	Lung
COSM5726728	c.471G>A	p.R157R	Substitution - coding silent	Skin
COSM2753086	c.289A>G	p.S97G	Substitution - Missense	Large_intestine
COSM5815305	c.117C>T	p.H39H	Substitution - coding silent	Liver
COSM3362954	c.450C>T	p.L150L	Substitution - coding silent	Kidney
COSM4080152	c.936C>T	p.G312G	Substitution - coding silent	Stomach
COSM1395304	c.213C>T	p.V71V	Substitution - coding silent	Large_intestine
COSM1734899	c.457G>A	p.V153M	Substitution - Missense	Pancreas
COSM5000890	c.117C>A	p.H39Q	Substitution - Missense	Pancreas
COSM475041	c.273C>T	p.I91I	Substitution - coding silent	Kidney
COSM5097323	c.571+7G>A	p.?	Unknown	Large_intestine
COSM1395305	c.243T>C	p.F81F	Substitution - coding silent	Large_intestine
COSM5641119	c.422G>A	p.G141D	Substitution - Missense	Oesophagus
COSM5568476	c.218C>A	p.S73*	Substitution - Nonsense	Prostate
COSM4804153	c.715G>T	p.E239*	Substitution - Nonsense	Liver
COSM3357176	c.1026C>T	p.T342T	Substitution - coding silent	Large_intestine
COSM5468479	c.324_326delCAA	p.N109delN	Deletion - In frame	Large_intestine
COSM2753100	c.1008C>T	p.C336C	Substitution - coding silent	Oesophagus
COSM4080156	c.1027G>A	p.D343N	Substitution - Missense	Stomach
COSM4482287	c.186C>T	p.L62L	Substitution - coding silent	Skin
COSM1163199	c.182A>G	p.H61R	Substitution - Missense	Pancreas
COSM5632897	c.701_702insT	p.T235fs*21	Insertion - Frameshift	Oesophagus
COSM999381	c.1040G>A	p.R347H	Substitution - Missense	Endometrium
COSM4804153	c.715G>T	p.E239*	Substitution - Nonsense	Liver
COSM3536909	c.944C>T	p.P315L	Substitution - Missense	Skin
COSM3672977	c.443C>G	p.S148C	Substitution - Missense	Prostate
COSM3743050	c.582C>T	p.N194N	Substitution - coding silent	Liver
COSM713390	c.189C>T	p.F63F	Substitution - coding silent	Lung
COSM1263122	c.255C>T	p.A85A	Substitution - coding silent	Oesophagus
COSM5476095	c.598A>G	p.M200V	Substitution - Missense	Large_intestine
COSM999375	c.594C>T	p.F198F	Substitution - coding silent	Endometrium
COSM3893063	c.737C>T	p.P246L	Substitution - Missense	Skin
COSM4617961	c.738G>A	p.P246P	Substitution - coding silent	Large_intestine
COSM459890	c.490G>A	p.D164N	Substitution - Missense	Cervix
COSM1165173	c.987G>C	p.L329L	Substitution - coding silent	Large_intestine
COSM118842	c.873G>A	p.T291T	Substitution - coding silent	Ovary
COSM4080158	c.1042T>C	p.*348R	Nonstop extension	Stomach
COSM999377	c.858G>A	p.T286T	Substitution - coding silent	Endometrium
COSM78353	c.448C>T	p.L150F	Substitution - Missense	Ovary
COSM4717866	c.1040G>C	p.R347P	Substitution - Missense	Large_intestine
COSM4080145	c.647T>C	p.V216A	Substitution - Missense	Stomach
COSM4919609	c.429C>A	p.C143*	Substitution - Nonsense	Liver
COSM5894679	c.586T>A	p.Y196N	Substitution - Missense	Skin
COSM4080154	c.988G>C	p.D330H	Substitution - Missense	Stomach
COSM3357176	c.1026C>T	p.T342T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3536903	c.402C>T	p.I134I	Substitution - coding silent	Skin
COSM5002949	c.412G>A	p.E138K	Substitution - Missense	Pancreas
COSM3536905	c.737C>G	p.P246R	Substitution - Missense	Skin
COSM4080142	c.135C>T	p.D45D	Substitution - coding silent	Stomach
COSM273790	c.975_977delCAC	p.T326delT	Deletion - In frame	Large_intestine
COSM999380	c.949G>A	p.A317T	Substitution - Missense	Endometrium
COSM1315984	c.19G>T	p.V7L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4717864	c.844G>A	p.E282K	Substitution - Missense	Large_intestine
COSM4389932	c.235T>A	p.C79S	Substitution - Missense	Pancreas
COSM999379	c.948C>T	p.N316N	Substitution - coding silent	Endometrium
COSM5606005	c.634C>T	p.L212L	Substitution - coding silent	Skin
COSM5139986	c.121-4C>A	p.?	Unknown	Large_intestine
COSM1193168	c.775G>T	p.A259S	Substitution - Missense	Lung

> Text Mining based Variations [ TOP ]
There is no record for PRMT1.

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q99873	294	S	Phosphoserine	-	No	None detected
Q99873	297	S	Phosphoserine	-	No	None detected

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.94	7.515	0.536	0.000233	NS
BRCA	Breast invasive carcinoma	112	1100	6.11	6.639	0.591	1.18e-21	Over
CESC	Cervical and endocervical cancers	3	306	7.573	7.141	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.466	7.5	1.12	3.68e-20	Over
ESCA	Esophageal carcinoma	11	185	5.345	6.535	0.999	7.87e-07	Over
GBM	Glioblastoma multiforme	5	166	6.471	7.266	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.925	7.12	0.22	0.0134	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.082	6.39	0.291	7.97e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.423	6.711	0.312	5.02e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.53	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.593	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.298	5.6	0.433	2.14e-05	NS
LUAD	Lung adenocarcinoma	59	517	6.279	6.666	0.374	8.25e-07	NS
LUSC	Lung squamous cell carcinoma	51	501	6.439	7.458	0.956	5.62e-27	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.246	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.677	6.717	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.197	7.138	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.775	6.844	0.124	0.0594	NS
READ	Rectum adenocarcinoma	10	167	6.614	7.553	1.003	0.000365	Over
SARC	Sarcoma	2	263	6.677	6.713	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.003	7.062	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.404	6.647	0.255	0.0271	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.868	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.666	6.905	0.278	1.82e-07	NS
THYM	Thymoma	2	120	6.729	7.406	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.376	7.822	0.556	4.63e-06	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12.3
Autonomic ganglia	CHP212	12.9
Autonomic ganglia	IMR32	12.6
Autonomic ganglia	KELLY	13.1
Autonomic ganglia	KPNRTBM1	12.9
Autonomic ganglia	KPNSI9S	12.7
Autonomic ganglia	KPNYN	13
Autonomic ganglia	MHHNB11	12.4
Autonomic ganglia	NB1	11.9
Autonomic ganglia	NH6	12.9
Autonomic ganglia	SHSY5Y	12.4
Autonomic ganglia	SIMA	12.7
Autonomic ganglia	SKNAS	13
Autonomic ganglia	SKNBE2	12.9
Autonomic ganglia	SKNDZ	12.5
Autonomic ganglia	SKNFI	12.2
Autonomic ganglia	SKNSH	12.8
Biliary tract	HUCCT1	12.2
Biliary tract	HUH28	11.3
Biliary tract	SNU1079	11.8
Biliary tract	SNU1196	12.8
Biliary tract	SNU245	12.8
Biliary tract	SNU308	12.7
Biliary tract	SNU478	13.1
Bone	143B	12.4
Bone	A673	13.2
Bone	CADOES1	12.5
Bone	CAL78	11.1
Bone	G292CLONEA141B1	12.1
Bone	HOS	12.4
Bone	HS706T	11.6
Bone	HS737T	11.5
Bone	HS819T	11.2
Bone	HS821T	11.3
Bone	HS822T	11.2
Bone	HS863T	11.3
Bone	HS870T	11.8
Bone	HS888T	11.3
Bone	MG63	12.5
Bone	MHHES1	11.5
Bone	OUMS27	11.8
Bone	RDES	12.8
Bone	SJSA1	12.4
Bone	SKES1	13
Bone	SKNMC	13.3
Bone	SW1353	11.5
Bone	T173	11.4
Bone	TC71	12.9
Bone	U2OS	12.8
Breast	AU565	11.8
Breast	BT20	12.5
Breast	BT474	12.3
Breast	BT483	11.5
Breast	BT549	12.4
Breast	CAL120	13.5
Breast	CAL148	11.6
Breast	CAL51	12
Breast	CAL851	12.1
Breast	CAMA1	11.9
Breast	DU4475	11.9
Breast	EFM192A	12.5
Breast	EFM19	12.6
Breast	EVSAT	12.3
Breast	HCC1143	12.7
Breast	HCC1187	12.9
Breast	HCC1395	12.2
Breast	HCC1419	11.3
Breast	HCC1428	11.5
Breast	HCC1500	11.8
Breast	HCC1569	12.5
Breast	HCC1599	11.1
Breast	HCC1806	11.9
Breast	HCC1937	12.1
Breast	HCC1954	11.5
Breast	HCC202	11.9
Breast	HCC2157	11.9
Breast	HCC2218	11.8
Breast	HCC38	12.1
Breast	HCC70	11.7
Breast	HDQP1	10.9
Breast	HMC18	12.3
Breast	HS274T	10.9
Breast	HS281T	11.5
Breast	HS343T	11.1
Breast	HS578T	12.3
Breast	HS606T	11.7
Breast	HS739T	11.9
Breast	HS742T	11.3
Breast	JIMT1	12.3
Breast	KPL1	12.4
Breast	MCF7	12.6
Breast	MDAMB134VI	11.5
Breast	MDAMB157	11.1
Breast	MDAMB175VII	12
Breast	MDAMB231	12.4
Breast	MDAMB361	12.5
Breast	MDAMB415	11
Breast	MDAMB436	11.9
Breast	MDAMB453	12.4
Breast	MDAMB468	12.1
Breast	SKBR3	11.8
Breast	T47D	11.4
Breast	UACC812	11.1
Breast	UACC893	10.4
Breast	YMB1	12.2
Breast	ZR751	12
Breast	ZR7530	11.2
Central nervous system	1321N1	12
Central nervous system	42MGBA	12.3
Central nervous system	8MGBA	11.6
Central nervous system	A172	12.6
Central nervous system	AM38	12.1
Central nervous system	BECKER	12.3
Central nervous system	CAS1	12.2
Central nervous system	CCFSTTG1	11.9
Central nervous system	D283MED	13.2
Central nervous system	D341MED	12.8
Central nervous system	DAOY	12
Central nervous system	DBTRG05MG	11.7
Central nervous system	DKMG	11.1
Central nervous system	GAMG	12.1
Central nervous system	GB1	12
Central nervous system	GI1	12.7
Central nervous system	GMS10	12.1
Central nervous system	GOS3	12.1
Central nervous system	H4	13.2
Central nervous system	HS683	11.7
Central nervous system	KALS1	11.9
Central nervous system	KG1C	12
Central nervous system	KNS42	11.9
Central nervous system	KNS60	11.1
Central nervous system	KNS81	12
Central nervous system	KS1	11.8
Central nervous system	LN18	12.6
Central nervous system	LN229	11.4
Central nervous system	M059K	12.4
Central nervous system	MOGGCCM	11.8
Central nervous system	MOGGUVW	12.2
Central nervous system	NMCG1	11.8
Central nervous system	ONS76	12.2
Central nervous system	SF126	12.3
Central nervous system	SF295	13.1
Central nervous system	SNB19	12.2
Central nervous system	SNU1105	11.5
Central nervous system	SNU201	11.5
Central nervous system	SNU466	11.4
Central nervous system	SNU489	12.2
Central nervous system	SNU626	10.8
Central nervous system	SNU738	11.5
Central nervous system	SW1088	11.9
Central nervous system	SW1783	12.1
Central nervous system	T98G	12.1
Central nervous system	TM31	11.2
Central nervous system	U118MG	11.6
Central nervous system	U138MG	11.9
Central nervous system	U251MG	12
Central nervous system	U87MG	12.2
Central nervous system	YH13	12.9
Central nervous system	YKG1	12.5
Endometrium	AN3CA	13
Endometrium	COLO684	13.1
Endometrium	EFE184	11.8
Endometrium	EN	13.2
Endometrium	ESS1	12.8
Endometrium	HEC108	11.9
Endometrium	HEC151	12.8
Endometrium	HEC1A	12.9
Endometrium	HEC1B	12.5
Endometrium	HEC251	12.4
Endometrium	HEC265	12.3
Endometrium	HEC50B	12.3
Endometrium	HEC59	12.1
Endometrium	HEC6	11.6
Endometrium	ISHIKAWAHERAKLIO02ER	12
Endometrium	JHUEM1	12.8
Endometrium	JHUEM2	12.5
Endometrium	JHUEM3	11.8
Endometrium	KLE	12.7
Endometrium	MFE280	12.8
Endometrium	MFE296	13.1
Endometrium	MFE319	12.5
Endometrium	RL952	12.5
Endometrium	SNGM	12.8
Endometrium	SNU1077	12.4
Endometrium	SNU685	12.3
Endometrium	TEN	12.1
Haematopoietic and lymphoid	697	12.8
Haematopoietic and lymphoid	A3KAW	13
Haematopoietic and lymphoid	A4FUK	12.9
Haematopoietic and lymphoid	ALLSIL	12.5
Haematopoietic and lymphoid	AML193	12.1
Haematopoietic and lymphoid	AMO1	13
Haematopoietic and lymphoid	BCP1	12.8
Haematopoietic and lymphoid	BDCM	13.1
Haematopoietic and lymphoid	BL41	12.5
Haematopoietic and lymphoid	BL70	12.8
Haematopoietic and lymphoid	BV173	12.1
Haematopoietic and lymphoid	CA46	12.5
Haematopoietic and lymphoid	CI1	13.5
Haematopoietic and lymphoid	CMK115	12.7
Haematopoietic and lymphoid	CMK86	12
Haematopoietic and lymphoid	CMK	12.5
Haematopoietic and lymphoid	CMLT1	12.3
Haematopoietic and lymphoid	COLO775	12.5
Haematopoietic and lymphoid	DAUDI	12.6
Haematopoietic and lymphoid	DB	13.6
Haematopoietic and lymphoid	DEL	11.1
Haematopoietic and lymphoid	DND41	12.6
Haematopoietic and lymphoid	DOHH2	12.3
Haematopoietic and lymphoid	EB1	12.9
Haematopoietic and lymphoid	EB2	12.9
Haematopoietic and lymphoid	EHEB	12.6
Haematopoietic and lymphoid	EJM	12
Haematopoietic and lymphoid	EM2	12.6
Haematopoietic and lymphoid	EOL1	12.2
Haematopoietic and lymphoid	F36P	12
Haematopoietic and lymphoid	GA10	13.1
Haematopoietic and lymphoid	GDM1	12.4
Haematopoietic and lymphoid	GRANTA519	12.8
Haematopoietic and lymphoid	HDLM2	12.2
Haematopoietic and lymphoid	HDMYZ	11.9
Haematopoietic and lymphoid	HEL9217	12.7
Haematopoietic and lymphoid	HEL	12.7
Haematopoietic and lymphoid	HH	13.6
Haematopoietic and lymphoid	HL60	12.3
Haematopoietic and lymphoid	HPBALL	12.4
Haematopoietic and lymphoid	HS604T	11.6
Haematopoietic and lymphoid	HS611T	12.9
Haematopoietic and lymphoid	HS616T	11.7
Haematopoietic and lymphoid	HS751T	10.8
Haematopoietic and lymphoid	HT	13
Haematopoietic and lymphoid	HTK	12.7
Haematopoietic and lymphoid	HUNS1	13.3
Haematopoietic and lymphoid	HUT102	12
Haematopoietic and lymphoid	HUT78	13
Haematopoietic and lymphoid	JEKO1	12.2
Haematopoietic and lymphoid	JK1	11
Haematopoietic and lymphoid	JM1	12.8
Haematopoietic and lymphoid	JURKAT	12.1
Haematopoietic and lymphoid	JURLMK1	12.1
Haematopoietic and lymphoid	JVM2	12.1
Haematopoietic and lymphoid	JVM3	12.7
Haematopoietic and lymphoid	K562	11.7
Haematopoietic and lymphoid	KARPAS299	10.6
Haematopoietic and lymphoid	KARPAS422	12.6
Haematopoietic and lymphoid	KARPAS620	12.6
Haematopoietic and lymphoid	KASUMI1	12
Haematopoietic and lymphoid	KASUMI2	12.6
Haematopoietic and lymphoid	KASUMI6	11.6
Haematopoietic and lymphoid	KCL22	12.8
Haematopoietic and lymphoid	KE37	11.1
Haematopoietic and lymphoid	KE97	13.2
Haematopoietic and lymphoid	KG1	12.7
Haematopoietic and lymphoid	KHM1B	12.2
Haematopoietic and lymphoid	KIJK	12.6
Haematopoietic and lymphoid	KMH2	12.6
Haematopoietic and lymphoid	KMM1	13.9
Haematopoietic and lymphoid	KMS11	13
Haematopoietic and lymphoid	KMS12BM	12.8
Haematopoietic and lymphoid	KMS18	12.2
Haematopoietic and lymphoid	KMS20	12.8
Haematopoietic and lymphoid	KMS21BM	13.4
Haematopoietic and lymphoid	KMS26	12.4
Haematopoietic and lymphoid	KMS27	13.1
Haematopoietic and lymphoid	KMS28BM	12.6
Haematopoietic and lymphoid	KMS34	12.3
Haematopoietic and lymphoid	KO52	11.9
Haematopoietic and lymphoid	KOPN8	12.7
Haematopoietic and lymphoid	KU812	12.6
Haematopoietic and lymphoid	KYO1	12.8
Haematopoietic and lymphoid	L1236	12.8
Haematopoietic and lymphoid	L363	11.6
Haematopoietic and lymphoid	L428	12.6
Haematopoietic and lymphoid	L540	11.6
Haematopoietic and lymphoid	LAMA84	11.9
Haematopoietic and lymphoid	LOUCY	12.5
Haematopoietic and lymphoid	LP1	11.9
Haematopoietic and lymphoid	M07E	12.7
Haematopoietic and lymphoid	MC116	13
Haematopoietic and lymphoid	ME1	12.8
Haematopoietic and lymphoid	MEC1	12.3
Haematopoietic and lymphoid	MEC2	13.1
Haematopoietic and lymphoid	MEG01	13.3
Haematopoietic and lymphoid	MHHCALL2	12.1
Haematopoietic and lymphoid	MHHCALL3	12.1
Haematopoietic and lymphoid	MHHCALL4	12.2
Haematopoietic and lymphoid	MINO	13
Haematopoietic and lymphoid	MJ	13.5
Haematopoietic and lymphoid	MM1S	12.8
Haematopoietic and lymphoid	MOLM13	13.1
Haematopoietic and lymphoid	MOLM16	12.4
Haematopoietic and lymphoid	MOLM6	11.9
Haematopoietic and lymphoid	MOLP2	12
Haematopoietic and lymphoid	MOLP8	11.9
Haematopoietic and lymphoid	MOLT13	12.1
Haematopoietic and lymphoid	MOLT16	11.6
Haematopoietic and lymphoid	MOLT4	13
Haematopoietic and lymphoid	MONOMAC1	11.8
Haematopoietic and lymphoid	MONOMAC6	12.5
Haematopoietic and lymphoid	MOTN1	11.4
Haematopoietic and lymphoid	MUTZ5	12.1
Haematopoietic and lymphoid	MV411	13.1
Haematopoietic and lymphoid	NALM19	12.8
Haematopoietic and lymphoid	NALM1	12.1
Haematopoietic and lymphoid	NALM6	12.1
Haematopoietic and lymphoid	NAMALWA	12.6
Haematopoietic and lymphoid	NB4	12.7
Haematopoietic and lymphoid	NCIH929	12.6
Haematopoietic and lymphoid	NCO2	12.8
Haematopoietic and lymphoid	NOMO1	12
Haematopoietic and lymphoid	NUDHL1	12.5
Haematopoietic and lymphoid	NUDUL1	12.6
Haematopoietic and lymphoid	OCIAML2	11.9
Haematopoietic and lymphoid	OCIAML3	12
Haematopoietic and lymphoid	OCIAML5	11.6
Haematopoietic and lymphoid	OCILY10	13
Haematopoietic and lymphoid	OCILY19	12.5
Haematopoietic and lymphoid	OCILY3	13.6
Haematopoietic and lymphoid	OCIM1	11.3
Haematopoietic and lymphoid	OPM2	12.1
Haematopoietic and lymphoid	P12ICHIKAWA	12.5
Haematopoietic and lymphoid	P31FUJ	12.3
Haematopoietic and lymphoid	P3HR1	13
Haematopoietic and lymphoid	PCM6	12.3
Haematopoietic and lymphoid	PEER	12.6
Haematopoietic and lymphoid	PF382	10.9
Haematopoietic and lymphoid	PFEIFFER	12.4
Haematopoietic and lymphoid	PL21	10.7
Haematopoietic and lymphoid	RAJI	13.4
Haematopoietic and lymphoid	RCHACV	12.7
Haematopoietic and lymphoid	REC1	13.1
Haematopoietic and lymphoid	REH	12.9
Haematopoietic and lymphoid	RI1	14
Haematopoietic and lymphoid	RL	11.9
Haematopoietic and lymphoid	RPMI8226	12.4
Haematopoietic and lymphoid	RPMI8402	12
Haematopoietic and lymphoid	RS411	12.8
Haematopoietic and lymphoid	SEM	12.8
Haematopoietic and lymphoid	SET2	12.4
Haematopoietic and lymphoid	SIGM5	12.2
Haematopoietic and lymphoid	SKM1	11.5
Haematopoietic and lymphoid	SKMM2	12.6
Haematopoietic and lymphoid	SR786	10.7
Haematopoietic and lymphoid	ST486	12.7
Haematopoietic and lymphoid	SUDHL10	12.5
Haematopoietic and lymphoid	SUDHL1	12
Haematopoietic and lymphoid	SUDHL4	12.5
Haematopoietic and lymphoid	SUDHL5	12.5
Haematopoietic and lymphoid	SUDHL6	12.6
Haematopoietic and lymphoid	SUDHL8	12.3
Haematopoietic and lymphoid	SUPB15	12.8
Haematopoietic and lymphoid	SUPHD1	11.8
Haematopoietic and lymphoid	SUPM2	10.7
Haematopoietic and lymphoid	SUPT11	12.5
Haematopoietic and lymphoid	SUPT1	13.2
Haematopoietic and lymphoid	TALL1	12.5
Haematopoietic and lymphoid	TF1	12.9
Haematopoietic and lymphoid	THP1	12.3
Haematopoietic and lymphoid	TO175T	11.3
Haematopoietic and lymphoid	TOLEDO	12.9
Haematopoietic and lymphoid	U266B1	12.3
Haematopoietic and lymphoid	U937	12.1
Haematopoietic and lymphoid	UT7	11.7
Haematopoietic and lymphoid	WSUDLCL2	11.9
Kidney	769P	12.8
Kidney	786O	12.6
Kidney	A498	12.3
Kidney	A704	10.9
Kidney	ACHN	12.3
Kidney	BFTC909	11.6
Kidney	CAKI1	12.3
Kidney	CAKI2	12.7
Kidney	CAL54	11.3
Kidney	KMRC1	12.6
Kidney	KMRC20	11.9
Kidney	KMRC2	12.4
Kidney	KMRC3	11.2
Kidney	OSRC2	12.3
Kidney	RCC10RGB	11.5
Kidney	SNU1272	11.4
Kidney	SNU349	11.1
Kidney	TUHR10TKB	11.6
Kidney	TUHR14TKB	11.6
Kidney	TUHR4TKB	11.6
Kidney	VMRCRCW	11.9
Kidney	VMRCRCZ	12.3
Large intestine	C2BBE1	13
Large intestine	CCK81	13
Large intestine	CL11	12.2
Large intestine	CL14	12.1
Large intestine	CL34	11.7
Large intestine	CL40	11.7
Large intestine	COLO205	11.7
Large intestine	COLO320	12.2
Large intestine	COLO678	11.1
Large intestine	CW2	12.7
Large intestine	DLD1	12.5
Large intestine	GP2D	12.3
Large intestine	HCC56	12.5
Large intestine	HCT116	13.2
Large intestine	HCT15	13.3
Large intestine	HS675T	11.5
Large intestine	HS698T	11
Large intestine	HT115	12
Large intestine	HT29	13.2
Large intestine	HT55	11.9
Large intestine	KM12	12.7
Large intestine	LOVO	12.5
Large intestine	LS1034	12.5
Large intestine	LS123	12.4
Large intestine	LS180	12.6
Large intestine	LS411N	12.4
Large intestine	LS513	11.3
Large intestine	MDST8	12.4
Large intestine	NCIH508	11.9
Large intestine	NCIH716	12.3
Large intestine	NCIH747	12.4
Large intestine	OUMS23	12
Large intestine	RCM1	11.6
Large intestine	RKO	12.4
Large intestine	SKCO1	12
Large intestine	SNU1040	11.8
Large intestine	SNU1197	11.7
Large intestine	SNU175	11.5
Large intestine	SNU283	11.8
Large intestine	SNU407	12.6
Large intestine	SNU503	12.5
Large intestine	SNU61	12
Large intestine	SNU81	11.6
Large intestine	SNUC1	11.6
Large intestine	SNUC2A	12.2
Large intestine	SNUC4	12.2
Large intestine	SNUC5	12.4
Large intestine	SW1116	11.7
Large intestine	SW1417	12.9
Large intestine	SW1463	12.1
Large intestine	SW403	11.6
Large intestine	SW480	13
Large intestine	SW48	12
Large intestine	SW620	12.8
Large intestine	SW837	11.6
Large intestine	SW948	11.9
Large intestine	T84	12.4
Liver	ALEXANDERCELLS	11.8
Liver	C3A	12.4
Liver	HEP3B217	12.3
Liver	HEPG2	12.9
Liver	HLE	12
Liver	HLF	12.6
Liver	HUH1	12.6
Liver	HUH6	11.2
Liver	HUH7	13.1
Liver	JHH1	13.1
Liver	JHH2	12.3
Liver	JHH4	12.8
Liver	JHH5	13.4
Liver	JHH6	11.3
Liver	JHH7	12.9
Liver	LI7	12.5
Liver	PLCPRF5	12.3
Liver	SKHEP1	12.2
Liver	SNU182	12.7
Liver	SNU387	11.7
Liver	SNU398	13
Liver	SNU423	11.9
Liver	SNU449	12.2
Liver	SNU475	12.2
Liver	SNU761	11.7
Liver	SNU878	12.3
Liver	SNU886	12.5
Lung	A549	13.1
Lung	ABC1	12.6
Lung	BEN	12
Lung	CAL12T	12.2
Lung	CALU1	12
Lung	CALU3	12.3
Lung	CALU6	12.9
Lung	CHAGOK1	11.4
Lung	COLO668	11.4
Lung	COLO699	11.8
Lung	CORL105	12.4
Lung	CORL23	12.9
Lung	CORL24	11.9
Lung	CORL279	12.4
Lung	CORL311	12.7
Lung	CORL47	12.2
Lung	CORL51	12.3
Lung	CORL88	12
Lung	CORL95	11.9
Lung	CPCN	12.5
Lung	DMS114	11.8
Lung	DMS153	11.8
Lung	DMS273	13
Lung	DMS454	11.4
Lung	DMS53	11.7
Lung	DMS79	12.5
Lung	DV90	12.6
Lung	EBC1	12.6
Lung	EPLC272H	12
Lung	HARA	12.6
Lung	HCC1171	11.5
Lung	HCC1195	11.2
Lung	HCC15	12.2
Lung	HCC2279	12
Lung	HCC2935	11.2
Lung	HCC33	11.8
Lung	HCC366	12.1
Lung	HCC4006	10.6
Lung	HCC44	13.1
Lung	HCC78	12.1
Lung	HCC827	11.9
Lung	HCC95	11.6
Lung	HLC1	12.4
Lung	HLFA	11.9
Lung	HS229T	12.3
Lung	HS618T	12.1
Lung	IALM	13
Lung	KNS62	12.8
Lung	LC1F	12.3
Lung	LC1SQSF	11.2
Lung	LCLC103H	11.7
Lung	LCLC97TM1	12.1
Lung	LK2	13
Lung	LOUNH91	12.6
Lung	LU65	13.3
Lung	LU99	12.8
Lung	LUDLU1	12
Lung	LXF289	11.3
Lung	MORCPR	12.4
Lung	NCIH1048	12.2
Lung	NCIH1092	11.3
Lung	NCIH1105	11.6
Lung	NCIH1155	12.4
Lung	NCIH1184	12.5
Lung	NCIH1299	12.8
Lung	NCIH1339	13
Lung	NCIH1341	12.8
Lung	NCIH1355	12.8
Lung	NCIH1373	12.2
Lung	NCIH1385	12.1
Lung	NCIH1395	11.8
Lung	NCIH1435	11.6
Lung	NCIH1436	12.8
Lung	NCIH1437	11.4
Lung	NCIH146	13
Lung	NCIH1563	11.7
Lung	NCIH1568	12.3
Lung	NCIH1573	11.7
Lung	NCIH1581	12
Lung	NCIH1618	12.5
Lung	NCIH1623	12.3
Lung	NCIH1648	12
Lung	NCIH1650	12.9
Lung	NCIH1651	11.6
Lung	NCIH1666	12.3
Lung	NCIH1693	11.7
Lung	NCIH1694	12.4
Lung	NCIH1703	12.4
Lung	NCIH1734	12.6
Lung	NCIH1755	12.9
Lung	NCIH1781	11.6
Lung	NCIH1792	13.2
Lung	NCIH1793	12.6
Lung	NCIH1836	12.6
Lung	NCIH1838	11.7
Lung	NCIH1869	11.7
Lung	NCIH1876	12.4
Lung	NCIH1915	12
Lung	NCIH1930	12.3
Lung	NCIH1944	12.6
Lung	NCIH1963	12.3
Lung	NCIH196	11.6
Lung	NCIH1975	12.1
Lung	NCIH2009	11.7
Lung	NCIH2023	12.9
Lung	NCIH2029	12.5
Lung	NCIH2030	12.3
Lung	NCIH2066	12.9
Lung	NCIH2081	11.9
Lung	NCIH2085	12.8
Lung	NCIH2087	11.5
Lung	NCIH209	12.5
Lung	NCIH2106	11.9
Lung	NCIH2110	11.2
Lung	NCIH211	13.6
Lung	NCIH2122	12.7
Lung	NCIH2126	12.1
Lung	NCIH2141	12
Lung	NCIH2170	13.6
Lung	NCIH2171	12.9
Lung	NCIH2172	10.7
Lung	NCIH2196	12.3
Lung	NCIH2227	11.5
Lung	NCIH2228	12
Lung	NCIH226	12.8
Lung	NCIH2286	11.5
Lung	NCIH2291	12.4
Lung	NCIH2342	12.4
Lung	NCIH2347	12.3
Lung	NCIH23	12.8
Lung	NCIH2405	12
Lung	NCIH2444	12.7
Lung	NCIH292	11.7
Lung	NCIH322	12.3
Lung	NCIH3255	11.8
Lung	NCIH358	12.8
Lung	NCIH441	12.2
Lung	NCIH446	12.9
Lung	NCIH460	12.5
Lung	NCIH510	13.1
Lung	NCIH520	13
Lung	NCIH522	11.5
Lung	NCIH524	13.4
Lung	NCIH526	12.7
Lung	NCIH596	11.2
Lung	NCIH647	12.5
Lung	NCIH650	12.3
Lung	NCIH661	11.7
Lung	NCIH69	12.6
Lung	NCIH727	11.5
Lung	NCIH810	12.9
Lung	NCIH82	13.4
Lung	NCIH838	12.4
Lung	NCIH841	12.1
Lung	NCIH854	12.5
Lung	NCIH889	13.3
Lung	PC14	12.1
Lung	RERFLCAD1	12.1
Lung	RERFLCAD2	12.3
Lung	RERFLCAI	12.6
Lung	RERFLCKJ	11.2
Lung	RERFLCMS	12.1
Lung	RERFLCSQ1	12.2
Lung	SBC5	11.9
Lung	SCLC21H	12.5
Lung	SHP77	12.1
Lung	SKLU1	12.7
Lung	SKMES1	12.3
Lung	SQ1	12.1
Lung	SW1271	12.9
Lung	SW1573	11.6
Lung	SW900	12.8
Lung	VMRCLCD	12.3
Lung	VMRCLCP	12
Oesophagus	COLO680N	11.1
Oesophagus	ECGI10	11.6
Oesophagus	KYSE140	12.6
Oesophagus	KYSE150	12.6
Oesophagus	KYSE180	12.4
Oesophagus	KYSE270	11.6
Oesophagus	KYSE30	11.5
Oesophagus	KYSE410	12.9
Oesophagus	KYSE450	13.1
Oesophagus	KYSE510	13.1
Oesophagus	KYSE520	12.3
Oesophagus	KYSE70	12.2
Oesophagus	OE19	12.7
Oesophagus	OE33	12
Oesophagus	TE10	11.8
Oesophagus	TE11	12.1
Oesophagus	TE14	11.9
Oesophagus	TE15	11.8
Oesophagus	TE1	12.3
Oesophagus	TE4	12
Oesophagus	TE5	10.9
Oesophagus	TE6	12.4
Oesophagus	TE8	12.5
Oesophagus	TE9	12.3
Oesophagus	TT	11.4
Ovary	59M	11.7
Ovary	A2780	13
Ovary	CAOV3	12.1
Ovary	CAOV4	12.5
Ovary	COLO704	13.9
Ovary	COV318	12.3
Ovary	COV362	11
Ovary	COV434	11.9
Ovary	COV504	12.5
Ovary	COV644	11.5
Ovary	EFO21	11.7
Ovary	EFO27	12.8
Ovary	ES2	12.4
Ovary	FUOV1	12.4
Ovary	HEYA8	12.9
Ovary	HS571T	11.7
Ovary	IGROV1	12.9
Ovary	JHOC5	12.2
Ovary	JHOM1	11.9
Ovary	JHOM2B	10.7
Ovary	JHOS2	12.1
Ovary	JHOS4	12.5
Ovary	KURAMOCHI	11.3
Ovary	MCAS	12.9
Ovary	NIHOVCAR3	12.5
Ovary	OAW28	11.7
Ovary	OAW42	12.5
Ovary	OC314	12.4
Ovary	OC316	12.6
Ovary	ONCODG1	12.2
Ovary	OV56	11.7
Ovary	OV7	11.9
Ovary	OV90	12.7
Ovary	OVCAR4	12.6
Ovary	OVCAR8	11.7
Ovary	OVISE	12.4
Ovary	OVK18	12.5
Ovary	OVKATE	11.8
Ovary	OVMANA	11.2
Ovary	OVSAHO	12.2
Ovary	OVTOKO	12.2
Ovary	RMGI	13.4
Ovary	RMUGS	13
Ovary	SKOV3	12.1
Ovary	SNU119	12
Ovary	SNU840	12.1
Ovary	SNU8	12.8
Ovary	TOV112D	13.1
Ovary	TOV21G	12.6
Ovary	TYKNU	12.8
Pancreas	ASPC1	11.7
Pancreas	BXPC3	13.4
Pancreas	CAPAN1	12.6
Pancreas	CAPAN2	12.3
Pancreas	CFPAC1	11.7
Pancreas	DANG	12.6
Pancreas	HPAC	11.7
Pancreas	HPAFII	11.5
Pancreas	HS766T	12.3
Pancreas	HUPT3	12.6
Pancreas	HUPT4	12.1
Pancreas	KCIMOH1	12.4
Pancreas	KLM1	12.3
Pancreas	KP2	12.4
Pancreas	KP3	11.2
Pancreas	KP4	12.2
Pancreas	L33	12.8
Pancreas	MIAPACA2	13.1
Pancreas	PANC0203	12.1
Pancreas	PANC0213	11.6
Pancreas	PANC0327	12.2
Pancreas	PANC0403	11.8
Pancreas	PANC0504	12.3
Pancreas	PANC0813	11.8
Pancreas	PANC1005	12.9
Pancreas	PANC1	12.3
Pancreas	PATU8902	12.7
Pancreas	PATU8988S	12.5
Pancreas	PATU8988T	12.8
Pancreas	PK1	13
Pancreas	PK45H	11.2
Pancreas	PK59	12.9
Pancreas	PL45	12.6
Pancreas	PSN1	12.9
Pancreas	QGP1	12.2
Pancreas	SNU213	11.6
Pancreas	SNU324	12.5
Pancreas	SNU410	11.6
Pancreas	SU8686	11.1
Pancreas	SUIT2	11.2
Pancreas	SW1990	13
Pancreas	T3M4	11.5
Pancreas	TCCPAN2	12.6
Pancreas	YAPC	11.7
Pleura	ACCMESO1	11.8
Pleura	DM3	11.6
Pleura	ISTMES1	12.6
Pleura	ISTMES2	12.9
Pleura	JL1	12.3
Pleura	MPP89	12.8
Pleura	MSTO211H	13
Pleura	NCIH2052	12.4
Pleura	NCIH2452	11.7
Pleura	NCIH28	12.6
Prostate	22RV1	12.8
Prostate	DU145	12.3
Prostate	LNCAPCLONEFGC	12.1
Prostate	MDAPCA2B	12.7
Prostate	NCIH660	10.8
Prostate	PC3	12.7
Prostate	VCAP	12.5
Salivary gland	A253	11.4
Salivary gland	YD15	11.7
Skin	A101D	12.2
Skin	A2058	12.1
Skin	A375	12.9
Skin	C32	11.7
Skin	CHL1	12.5
Skin	CJM	10.5
Skin	COLO679	12.3
Skin	COLO741	12.1
Skin	COLO783	12
Skin	COLO792	11.2
Skin	COLO800	11.5
Skin	COLO818	10.7
Skin	COLO829	11.8
Skin	COLO849	12.1
Skin	G361	12.8
Skin	GRM	12.6
Skin	HMCB	12.8
Skin	HS294T	12.3
Skin	HS600T	11.4
Skin	HS688AT	11.4
Skin	HS695T	12.1
Skin	HS839T	11.3
Skin	HS852T	11
Skin	HS895T	11.7
Skin	HS934T	11
Skin	HS936T	10.8
Skin	HS939T	11.6
Skin	HS940T	11.6
Skin	HS944T	12.7
Skin	HT144	12.3
Skin	IGR1	12
Skin	IGR37	12.6
Skin	IGR39	12.2
Skin	IPC298	12.3
Skin	K029AX	12.3
Skin	LOXIMVI	12.6
Skin	MALME3M	11.5
Skin	MDAMB435S	11.2
Skin	MELHO	12.3
Skin	MELJUSO	12.6
Skin	MEWO	12
Skin	RPMI7951	12
Skin	RVH421	12.3
Skin	SH4	11.3
Skin	SKMEL1	12
Skin	SKMEL24	12
Skin	SKMEL28	12
Skin	SKMEL2	12.2
Skin	SKMEL30	11.1
Skin	SKMEL31	10.6
Skin	SKMEL3	12
Skin	SKMEL5	11.9
Skin	UACC257	12.5
Skin	UACC62	12.8
Skin	WM115	12.2
Skin	WM1799	11.3
Skin	WM2664	11.7
Skin	WM793	11.1
Skin	WM88	11.4
Skin	WM983B	11.4
Small intestine	HUTU80	12.6
Soft tissue	A204	12.6
Soft tissue	G401	13.2
Soft tissue	G402	12.6
Soft tissue	GCT	12.4
Soft tissue	HS729	11.7
Soft tissue	HT1080	12.7
Soft tissue	KYM1	12.2
Soft tissue	MESSA	12.3
Soft tissue	RD	12.3
Soft tissue	RH30	12.9
Soft tissue	RH41	13
Soft tissue	RKN	12.5
Soft tissue	S117	11.7
Soft tissue	SJRH30	13.2
Soft tissue	SKLMS1	12.3
Soft tissue	SKUT1	12.8
Soft tissue	TE125T	11
Soft tissue	TE159T	10.6
Soft tissue	TE441T	12
Soft tissue	TE617T	12.4
Stomach	2313287	11.8
Stomach	AGS	13.1
Stomach	AZ521	12.8
Stomach	ECC10	12.7
Stomach	ECC12	12.1
Stomach	FU97	13.2
Stomach	GCIY	13.2
Stomach	GSS	12.4
Stomach	GSU	11.8
Stomach	HGC27	12.1
Stomach	HS746T	11.9
Stomach	HUG1N	12.9
Stomach	IM95	12.1
Stomach	KATOIII	12.3
Stomach	KE39	12
Stomach	LMSU	12
Stomach	MKN1	11.7
Stomach	MKN45	12.4
Stomach	MKN74	11.9
Stomach	MKN7	12.1
Stomach	NCCSTCK140	12.1
Stomach	NCIN87	12.9
Stomach	NUGC2	11.9
Stomach	NUGC3	12.8
Stomach	NUGC4	11.5
Stomach	OCUM1	12.2
Stomach	RERFGC1B	13.1
Stomach	SH10TC	12.4
Stomach	SNU16	12.3
Stomach	SNU1	12.8
Stomach	SNU216	11.9
Stomach	SNU520	11.7
Stomach	SNU5	12.8
Stomach	SNU601	12.9
Stomach	SNU620	12.2
Stomach	SNU668	12.6
Stomach	SNU719	12.3
Stomach	TGBC11TKB	12.4
Thyroid	8305C	12.6
Thyroid	8505C	12.1
Thyroid	BCPAP	12.3
Thyroid	BHT101	11.8
Thyroid	CAL62	12.3
Thyroid	CGTHW1	12.3
Thyroid	FTC133	12.6
Thyroid	FTC238	11.9
Thyroid	ML1	11.7
Thyroid	SW579	12.5
Thyroid	TT2609C02	12.4
Thyroid	TT	11.6
Upper aerodigestive tract	BHY	11.4
Upper aerodigestive tract	BICR16	12.3
Upper aerodigestive tract	BICR18	12
Upper aerodigestive tract	BICR22	10.9
Upper aerodigestive tract	BICR31	11.4
Upper aerodigestive tract	BICR56	11.1
Upper aerodigestive tract	BICR6	12.1
Upper aerodigestive tract	CAL27	12.3
Upper aerodigestive tract	CAL33	11.5
Upper aerodigestive tract	DETROIT562	12
Upper aerodigestive tract	FADU	12.8
Upper aerodigestive tract	HS840T	11.9
Upper aerodigestive tract	HSC2	12.1
Upper aerodigestive tract	HSC3	12.2
Upper aerodigestive tract	HSC4	11.4
Upper aerodigestive tract	PECAPJ15	11.7
Upper aerodigestive tract	PECAPJ34CLONEC12	11.6
Upper aerodigestive tract	PECAPJ41CLONED2	11.3
Upper aerodigestive tract	PECAPJ49	12.6
Upper aerodigestive tract	SCC15	11.8
Upper aerodigestive tract	SCC25	11.2
Upper aerodigestive tract	SCC4	12.5
Upper aerodigestive tract	SCC9	11.6
Upper aerodigestive tract	SNU1076	11.3
Upper aerodigestive tract	SNU1214	11.2
Upper aerodigestive tract	SNU46	12.7
Upper aerodigestive tract	SNU899	11.6
Upper aerodigestive tract	YD10B	11.1
Upper aerodigestive tract	YD38	12
Upper aerodigestive tract	YD8	11.8
Urinary tract	5637	13.2
Urinary tract	639V	13.3
Urinary tract	647V	12.7
Urinary tract	BC3C	11.8
Urinary tract	BFTC905	12
Urinary tract	CAL29	11.4
Urinary tract	HS172T	10.7
Urinary tract	HT1197	11.1
Urinary tract	HT1376	11.4
Urinary tract	J82	12.7
Urinary tract	JMSU1	12.4
Urinary tract	KMBC2	11.4
Urinary tract	KU1919	11.5
Urinary tract	RT11284	12.1
Urinary tract	RT112	12.1
Urinary tract	RT4	13.2
Urinary tract	SCABER	11.9
Urinary tract	SW1710	11.8
Urinary tract	SW780	12.4
Urinary tract	T24	12.9
Urinary tract	TCCSUP	11.2
Urinary tract	UMUC1	12.3
Urinary tract	UMUC3	12.7
Urinary tract	VMCUB1	11.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	63
Adrenal gland	101.5
Appendix	105.8
Bone marrow	40.8
Breast	66
Cerebral cortex	71.8
Cervix, uterine	99.6
Colon	60.8
Duodenum	57
Endometrium	123.9
Epididymis	53.3
Esophagus	80
Fallopian tube	178.9
Gallbladder	78.4
Heart muscle	96.8
Kidney	39.9
Liver	18.5
Lung	75
Lymph node	109.6
Ovary	128.6
Pancreas	10.9
Parathyroid gland	75.8
Placenta	93.3
Prostate	82.9
Rectum	50.7
Salivary gland	24.1
Seminal vesicle	103.1
Skeletal muscle	84.1
Skin	67
Small intestine	53.7
Smooth muscle	107.2
Spleen	91
Stomach	45.1
Testis	101.8
Thyroid gland	102.3
Tonsil	80.3
Urinary bladder	81.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28656289	overexpression	Head and Neck Squamous Cell Carcinoma	Immunohistochemical analyses of specimens from typical HNC patients showed strong PRMT1 expression in the tumor cells compared with neighboring normal cells.
28040436	overexpression	Colorectal Carcinoma	Protein Arginine Methyl Transferase 1 (PRMT1) is deemed to be a potential oncogenic protein considering its overexpression in several malignancies including colorectal cancer.
27175582	Overexpression	Melanoma	In conclusion, the current results indicated that PRMT1 is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM.
26472729	Underexpression	Gastric Carcinoma	PRMT1 and FOXO1 in GC samples were predominantly expressed in the nucleus. Patients with lower PRMT1 expression (n = 131) had suppressed nuclear accumulation of FOXO1, higher recurrence after adjuvant chemotherapy, and poorer prognosis than those with higher PRMT1 expression (n = 64).
26045981	altered expression	Oesophagal Squamous Cell Carcinoma	Tissue microarray done in independent cohort of 75 patients revealed higher nuclear protein expression of KAT8 and PRMT1 in tumor similar to mRNA expression. Expression status of PRMT1 and KAT8 was found declined as we move from low grade to high grade tumor
24211191	Overexpression	Non-Small Cell Lung Cancer	We report that CARM1 and PRMT1 are significantly overexpressed in 60 patients with Non-Small Cell Lung Carcinomas (NSCLC).
22839530	Overexpression	Acute Lymphoblastic Leukemia	We identified significant up-regulation of SRSF1 and PRMT1 in the ND samples. Importantly, the expression of SRSF1 and PRMT1 returned to normal levels after CR, but rebounded in the RE samples.
19414388	Aberrant expression	Colon Carcinoma	In 18 inflamed colon tissues examined for PRMT1 expression and compared with the expression of 90 colon cancer tissue samples, statistical significance was found only for variants v1 and v2.
17848568	Aberrant expression	Breast Carcinoma	Finally, we find that the relative balance of PRMT1 isoforms is altered in breast cancer.
11097842	Aberrant expression	Breast Carcinoma	We have shown that the relative prevalence of alternatively spliced forms of PRMT1 is different between normal and cancerous breast tissues.

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.402	4.17e-17	15.3	45.8	38.9	Gain
BRCA	Breast invasive carcinoma	1075	0.408	1.76e-44	16.6	59.6	23.8	Neutral
CESC	Cervical and endocervical cancers	292	0.484	1.55e-18	12	59.6	28.4	Neutral
COAD	Colon adenocarcinoma	449	0.255	4.5e-08	9.8	71	19.2	Neutral
ESCA	Esophageal carcinoma	183	0.425	2.06e-09	27.9	46.4	25.7	Neutral
GBM	Glioblastoma multiforme	147	0.595	2.03e-15	17	59.2	23.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.395	1.23e-20	18.7	65.6	15.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.173	7e-05	1.1	88.2	10.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.156	0.00805	6.2	92.4	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.119	0.127	1.8	95.2	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.641	8.84e-61	50.5	45.2	4.3	Loss
LIHC	Liver hepatocellular carcinoma	364	0.473	1.05e-21	10.7	68.7	20.6	Neutral
LUAD	Lung adenocarcinoma	512	0.363	2.12e-17	36.9	48.6	14.5	Loss
LUSC	Lung squamous cell carcinoma	498	0.507	6.12e-34	28.3	39	32.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.561	2.84e-26	49	33	18	Loss
PAAD	Pancreatic adenocarcinoma	177	0.47	4.06e-11	11.3	70.6	18.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.309	6.31e-05	5.6	86.4	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.143	0.00144	4.9	92.1	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.373	8.97e-07	14	67.1	18.9	Neutral
SARC	Sarcoma	255	0.448	5.14e-14	31.8	48.6	19.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.439	1e-18	22.1	62.9	15	Neutral
STAD	Stomach adenocarcinoma	413	0.435	1.67e-20	17.2	59.3	23.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.055	0.503	38.7	43.3	18	Loss
THCA	Thyroid carcinoma	497	0.158	0.000396	0.2	97.8	2	Neutral
THYM	Thymoma	119	0.028	0.766	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.311	1.77e-13	11	77.5	11.5	Neutral

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.204	2.29e-05	17	408	-0.001	0.097	NS/NA
BRCA	Breast invasive carcinoma	-0.223	3.81e-11	83	785	-0.001	0.019	NS/NA
CESC	Cervical and endocervical cancers	-0.169	0.00284	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.069	0.224	19	297	0.012	0.942	NS/NA
ESCA	Esophageal carcinoma	-0.173	0.0158	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.177	0.158	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.112	0.00892	20	522	-0.001	0.424	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.239	8.32e-06	24	319	0.002	0.0114	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.135	0.0202	23	275	-0.01	8.94e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.077	0.319	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.4	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.167	0.00068	41	373	-0.008	0.268	NS/NA
LUAD	Lung adenocarcinoma	-0.167	0.000253	21	456	0.004	0.0116	NS/NA
LUSC	Lung squamous cell carcinoma	-0.264	2.12e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.7	0.0433	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.21	0.00435	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.071	0.332	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.206	1.77e-06	35	498	-0.001	0.757	NS/NA
READ	Rectum adenocarcinoma	-0.265	0.00749	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.179	0.00372	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.132	0.00414	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.089	0.0852	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.175	0.0292	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.179	2.16e-05	50	509	-0.003	0.172	NS/NA
THYM	Thymoma	-0.102	0.263	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.095	0.04	34	431	-0.002	0.026	NS/NA

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	1	Low
Bone marrow	1	Low
Breast	3	High
Bronchus	1	Low
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	1	Low
Endometrium	3	High
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	3	High
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	0	Not detected
Placenta	2	Medium
Prostate	2	Medium
Rectum	1	Low
Salivary gland	1	Low
Seminal vesicle	0	Not detected
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	3	High
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.497	NS	24476821
BRCA	Breast invasive carcinoma	521	9.43e-16	Significant	23000897
COAD	Colon adenocarcinoma	149	0.533	NS	22810696
GBM	Glioblastoma multiforme	157	0.00301	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.036	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.564	NS	26536169
LGG	Brain Lower Grade Glioma	513	7.96e-33	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.28e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0233	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.105	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.00417	Significant	26544944
READ	Rectum adenocarcinoma	67	0.817	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.7	NS	26091043
STAD	Stomach adenocarcinoma	277	4.11e-07	Significant	25079317
THCA	Thyroid carcinoma	391	0.223	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.12	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.974	0.898	NS
BRCA	Breast invasive carcinoma	1079	1.05	0.84	NS
CESC	Cervical and endocervical cancers	291	0.816	0.537	NS
COAD	Colon adenocarcinoma	439	0.668	0.166	NS
ESCA	Esophageal carcinoma	184	1.178	0.61	NS
GBM	Glioblastoma multiforme	158	0.794	0.36	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.544	0.0288	Shorter
KIRC	Kidney renal clear cell carcinoma	531	2.141	0.000657	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.701	0.2	NS
LAML	Acute Myeloid Leukemia	149	1.203	0.524	NS
LGG	Brain Lower Grade Glioma	511	1.268	0.368	NS
LIHC	Liver hepatocellular carcinoma	365	1.792	0.0128	Shorter
LUAD	Lung adenocarcinoma	502	1.515	0.0419	Shorter
LUSC	Lung squamous cell carcinoma	494	0.754	0.158	NS
OV	Ovarian serous cystadenocarcinoma	303	1.014	0.951	NS
PAAD	Pancreatic adenocarcinoma	177	0.696	0.226	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.0595	NS
PRAD	Prostate adenocarcinoma	497	2.234	0.488	NS
READ	Rectum adenocarcinoma	159	0.473	0.247	NS
SARC	Sarcoma	259	1.661	0.0819	NS
SKCM	Skin Cutaneous Melanoma	459	1.618	0.0124	Shorter
STAD	Stomach adenocarcinoma	388	0.87	0.533	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.364	0.128	NS
THYM	Thymoma	119	5.051	0.109	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.846	0.58	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.1	0.0432	Lower
BRCA	Breast invasive carcinoma	1071	0.015	0.634	NS
CESC	Cervical and endocervical cancers	167	-0.075	0.334	NS
COAD	Colon adenocarcinoma	445	-0.095	0.0461	Lower
ESCA	Esophageal carcinoma	162	-0.027	0.737	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.12	0.0113	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.106	0.0148	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.2	0.00117	Higher
LIHC	Liver hepatocellular carcinoma	347	0.109	0.0431	Higher
LUAD	Lung adenocarcinoma	507	0.093	0.0373	Higher
LUSC	Lung squamous cell carcinoma	497	0.099	0.0275	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.044	0.442	NS
PAAD	Pancreatic adenocarcinoma	176	-0.12	0.114	NS
READ	Rectum adenocarcinoma	156	-0.124	0.122	NS
SKCM	Skin Cutaneous Melanoma	410	-0.013	0.791	NS
STAD	Stomach adenocarcinoma	392	-0.038	0.459	NS
TGCT	Testicular Germ Cell Tumors	81	0.225	0.0435	Higher
THCA	Thyroid carcinoma	499	-0.016	0.718	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.052	0.246	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.226	0.000167	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.116	0.00951	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.132	0.00247	Higher
LGG	Brain Lower Grade Glioma	514	0.091	0.0383	Higher
LIHC	Liver hepatocellular carcinoma	366	0.172	0.000963	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.052	0.368	NS
PAAD	Pancreatic adenocarcinoma	176	-0.036	0.639	NS
STAD	Stomach adenocarcinoma	406	-0.021	0.669	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.103	0.0172	Higher

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB01752	S-Adenosyl-L-Homocysteine	Small Molecule Drug

Summary
Symbol	PRMT1
Name	protein arginine methyltransferase 1
Aliases	ANM1; HRMT1L2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase-like 2 (S. ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28040436	Colorectal Carcinoma	partner	FAM98A; FAM98B	positive correlation	Analysis of the data from The Cancer Genome Atlas (TCGA) database and clinical colorectal cancer specimens also demonstrated a strong positive correlation and co-occurrence of PRMT1, FAM98A and FAM98B.