CR2Cancer

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF05185 PRMT5 arginine-N-methyltransferase

Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3R8, H4R3	H3R8me, H4R3me	18404153

> Gene Ontology [ TOP ]
Biological Process	GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000387 spliceosomal snRNP assembly GO:0000398 mRNA splicing, via spliceosome GO:0001889 liver development GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006353 DNA-templated transcription, termination GO:0006397 mRNA processing GO:0006479 protein methylation GO:0007030 Golgi organization GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007212 dopamine receptor signaling pathway GO:0007346 regulation of mitotic cell cycle GO:0007623 circadian rhythm GO:0008213 protein alkylation GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0008380 RNA splicing GO:0010001 glial cell differentiation GO:0010720 positive regulation of cell development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0016570 histone modification GO:0016571 histone methylation GO:0018195 peptidyl-arginine modification GO:0018216 peptidyl-arginine methylation GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0032259 methylation GO:0032922 circadian regulation of gene expression GO:0034969 histone arginine methylation GO:0035246 peptidyl-arginine N-methylation GO:0035247 peptidyl-arginine omega-N-methylation GO:0042063 gliogenesis GO:0042118 endothelial cell activation GO:0043414 macromolecule methylation GO:0043985 histone H4-R3 methylation GO:0044030 regulation of DNA methylation GO:0044728 DNA methylation or demethylation GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway GO:0048511 rhythmic process GO:0048709 oligodendrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048714 positive regulation of oligodendrocyte differentiation GO:0048732 gland development GO:0050769 positive regulation of neurogenesis GO:0051052 regulation of DNA metabolic process GO:0051783 regulation of nuclear division GO:0051962 positive regulation of nervous system development GO:0060159 regulation of dopamine receptor signaling pathway GO:0060161 positive regulation of dopamine receptor signaling pathway GO:0061008 hepaticobiliary system development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0071826 ribonucleoprotein complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:0090161 Golgi ribbon formation GO:0097421 liver regeneration GO:1901796 regulation of signal transduction by p53 class mediator GO:1904990 regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
Molecular Function	GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0003714 transcription corepressor activity GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008327 methyl-CpG binding GO:0008469 histone-arginine N-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016273 arginine N-methyltransferase activity GO:0016274 protein-arginine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0035243 protein-arginine omega-N symmetric methyltransferase activity GO:0042054 histone methyltransferase activity GO:0043021 ribonucleoprotein complex binding GO:0044020 histone methyltransferase activity (H4-R3 specific) GO:0046982 protein heterodimerization activity
Cellular Component	GO:0034708 methyltransferase complex GO:0034709 methylosome GO:0035097 histone methyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03013 RNA transport
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-194441: Metabolism of non-coding RNA R-HSA-3214858: RMTs methylate histone arginines R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804760: Regulation of TP53 Activity through Methylation R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-191859: snRNP Assembly

> KEGG and Reactome Pathway

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KEGG

hsa03013 RNA transport

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-194441: Metabolism of non-coding RNA
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804760: Regulation of TP53 Activity through Methylation
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-191859: snRNP Assembly

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4049925	c.829T>C	p.F277L	Substitution - Missense	Stomach
COSM3793576	c.143C>A	p.P48Q	Substitution - Missense	Urinary_tract
COSM4049927	c.202C>T	p.R68*	Substitution - Nonsense	Stomach
COSM3690022	c.1697-2A>C	p.?	Unknown	Large_intestine
COSM954576	c.309C>T	p.S103S	Substitution - coding silent	Endometrium
COSM432867	c.646C>T	p.H216Y	Substitution - Missense	Breast
COSM78354	c.1006C>G	p.Q336E	Substitution - Missense	Ovary
COSM954562	c.1697-2A>G	p.?	Unknown	Endometrium
COSM1369108	c.856T>C	p.Y286H	Substitution - Missense	Large_intestine
COSM1323560	c.659G>A	p.R220H	Substitution - Missense	Ovary
COSM1707159	c.1621C>T	p.P541S	Substitution - Missense	Skin
COSM1300497	c.73G>A	p.E25K	Substitution - Missense	Urinary_tract
COSM1369113	c.1A>G	p.M1V	Substitution - Missense	Large_intestine
COSM954582	c.260C>A	p.S87Y	Substitution - Missense	Endometrium
COSM3814509	c.31G>T	p.G11W	Substitution - Missense	Breast
COSM1222112	c.239C>T	p.T80M	Substitution - Missense	Large_intestine
COSM1222114	c.1150C>T	p.R384W	Substitution - Missense	Large_intestine
COSM3495056	c.730C>T	p.P244S	Substitution - Missense	Skin
COSM5679473	c.1190C>G	p.A397G	Substitution - Missense	Soft_tissue
COSM317919	c.993C>A	p.P331P	Substitution - coding silent	Lung
COSM3772897	c.658C>T	p.R220C	Substitution - Missense	Pancreas
COSM4049923	c.1209C>T	p.N403N	Substitution - coding silent	Stomach
COSM469812	c.143C>T	p.P48L	Substitution - Missense	Kidney
COSM5652003	c.1889delG	p.G630fs*>8	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM469808	c.1223A>T	p.E408V	Substitution - Missense	Kidney
COSM4577767	c.1080A>G	p.V360V	Substitution - coding silent	Bone
COSM1195458	c.1895C>T	p.S632L	Substitution - Missense	Lung
COSM3793574	c.996C>G	p.I332M	Substitution - Missense	Urinary_tract
COSM5925809	c.1018-8C>T	p.?	Unknown	Skin
COSM3495048	c.1409C>T	p.S470F	Substitution - Missense	Skin
COSM4462477	c.1248C>T	p.V416V	Substitution - coding silent	Skin
COSM3885864	c.1410C>T	p.S470S	Substitution - coding silent	Skin
COSM954568	c.1199+1G>A	p.?	Unknown	Endometrium
COSM3987573	c.248T>C	p.V83A	Substitution - Missense	Kidney
COSM1607502	c.1042C>T	p.R348*	Substitution - Nonsense	Liver
COSM3495050	c.1365C>T	p.H455H	Substitution - coding silent	Skin
COSM954572	c.734T>C	p.V245A	Substitution - Missense	Endometrium
COSM4751218	c.1462A>G	p.R488G	Substitution - Missense	Stomach
COSM4717881	c.1772C>T	p.T591M	Substitution - Missense	Large_intestine
COSM1677875	c.567G>A	p.W189*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM697492	c.1006C>T	p.Q336*	Substitution - Nonsense	Urinary_tract
COSM3495052	c.1124C>T	p.S375F	Substitution - Missense	Skin
COSM4751220	c.450+2T>C	p.?	Unknown	Stomach
COSM125595	c.496G>A	p.D166N	Substitution - Missense	Upper_aerodigestive_tract
COSM284280	c.897C>A	p.L299L	Substitution - coding silent	Large_intestine
COSM5493141	c.1513C>T	p.R505W	Substitution - Missense	Biliary_tract
COSM1607502	c.1042C>T	p.R348*	Substitution - Nonsense	Liver
COSM697494	c.1778G>T	p.R593L	Substitution - Missense	Lung
COSM954560	c.1909C>A	p.L637I	Substitution - Missense	Endometrium
COSM3495052	c.1124C>T	p.S375F	Substitution - Missense	Skin
COSM1128292	c.111G>T	p.G37G	Substitution - coding silent	Prostate
COSM2030674	c.1815C>T	p.C605C	Substitution - coding silent	Large_intestine
COSM954578	c.298C>T	p.R100C	Substitution - Missense	Skin
COSM4823632	c.39C>T	p.R13R	Substitution - coding silent	Cervix
COSM254906	c.955C>G	p.L319V	Substitution - Missense	Urinary_tract
COSM254906	c.955C>G	p.L319V	Substitution - Missense	Urinary_tract
COSM3495054	c.916G>C	p.D306H	Substitution - Missense	Skin
COSM4571004	c.364T>A	p.F122I	Substitution - Missense	Skin
COSM954566	c.1204G>C	p.E402Q	Substitution - Missense	Endometrium
COSM4420591	c.644A>G	p.N215S	Substitution - Missense	Central_nervous_system
COSM954570	c.1096G>A	p.A366T	Substitution - Missense	Endometrium
COSM1707161	c.1543C>T	p.P515S	Substitution - Missense	Skin
COSM4333331	c.1093G>A	p.G365R	Substitution - Missense	Biliary_tract
COSM3711480	c.20G>T	p.G7V	Substitution - Missense	Upper_aerodigestive_tract
COSM5382082	c.267G>A	p.W89*	Substitution - Nonsense	Skin
COSM4466216	c.1421C>T	p.P474L	Substitution - Missense	Skin
COSM954564	c.1407T>C	p.T469T	Substitution - coding silent	Endometrium
COSM4717885	c.240G>A	p.T80T	Substitution - coding silent	Large_intestine
COSM954574	c.614-1G>T	p.?	Unknown	Endometrium
COSM5816335	c.352G>A	p.G118S	Substitution - Missense	Liver
COSM5801779	c.1580-12_1580-10delATT	p.?	Unknown	Breast
COSM697492	c.1006C>T	p.Q336*	Substitution - Nonsense	Lung
COSM1470678	c.614-1G>C	p.?	Unknown	Prostate
COSM2030702	c.766C>T	p.R256W	Substitution - Missense	Large_intestine
COSM954578	c.298C>T	p.R100C	Substitution - Missense	Endometrium
COSM381387	c.327_328GG>TT	p.Q109>?	Complex	Lung
COSM3814504	c.944T>C	p.L315P	Substitution - Missense	Breast
COSM3711480	c.20G>T	p.G7V	Substitution - Missense	Upper_aerodigestive_tract
COSM254906	c.955C>G	p.L319V	Substitution - Missense	Urinary_tract
COSM4404244	c.13G>A	p.A5T	Substitution - Missense	Skin
COSM183184	c.888C>A	p.A296A	Substitution - coding silent	Large_intestine
COSM4966391	c.775A>G	p.K259E	Substitution - Missense	Prostate
COSM4717883	c.927G>A	p.Q309Q	Substitution - coding silent	Large_intestine
COSM552603	c.15G>T	p.A5A	Substitution - coding silent	Lung
COSM4622919	c.1338G>A	p.S446S	Substitution - coding silent	Large_intestine
COSM432869	c.115G>C	p.D39H	Substitution - Missense	Breast
COSM3885866	c.443C>T	p.S148F	Substitution - Missense	Skin
COSM4837479	c.792C>T	p.F264F	Substitution - coding silent	Cervix
COSM1637533	c.23delG	p.G8fs*13	Deletion - Frameshift	Bone
COSM432863	c.1582C>T	p.P528S	Substitution - Missense	Breast
COSM3968736	c.1861G>A	p.V621I	Substitution - Missense	Central_nervous_system
COSM5925807	c.1018-7C>T	p.?	Unknown	Skin
COSM4845472	c.1433C>T	p.S478F	Substitution - Missense	Cervix
COSM3814506	c.507G>A	p.E169E	Substitution - coding silent	Breast
COSM6015446	c.875C>T	p.P292L	Substitution - Missense	Skin
COSM4049921	c.1490A>G	p.Q497R	Substitution - Missense	Stomach
COSM954580	c.272G>A	p.R91H	Substitution - Missense	Endometrium
COSM317919	c.993C>A	p.P331P	Substitution - coding silent	Soft_tissue
COSM125594	c.736C>T	p.L246F	Substitution - Missense	Upper_aerodigestive_tract
COSM126884	c.206C>G	p.S69*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM322830	c.858C>A	p.Y286*	Substitution - Nonsense	Lung
COSM1369104	c.1600C>T	p.R534C	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for PRMT5.

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.696	6.014	0.305	0.0703	NS
BRCA	Breast invasive carcinoma	112	1100	5.928	6.205	0.256	4.88e-07	NS
CESC	Cervical and endocervical cancers	3	306	5.931	6.302	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.76	6.477	0.733	3.01e-15	Over
ESCA	Esophageal carcinoma	11	185	5.152	6.112	0.704	0.000661	Over
GBM	Glioblastoma multiforme	5	166	5.581	6.371	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.151	6.307	0.145	0.122	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.214	5.832	-0.402	2.25e-09	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.176	5.946	-0.254	0.0216	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.129	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.374	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.738	5.066	0.316	0.000196	NS
LUAD	Lung adenocarcinoma	59	517	5.372	6.032	0.657	1.62e-15	Over
LUSC	Lung squamous cell carcinoma	51	501	5.434	6.269	0.844	1.1e-18	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.583	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.464	5.737	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.805	5.144	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.883	6.171	0.279	3.77e-07	NS
READ	Rectum adenocarcinoma	10	167	5.728	6.469	0.607	0.00188	Over
SARC	Sarcoma	2	263	5.871	6.019	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.017	6.29	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.462	5.941	0.402	0.000222	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.834	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.151	5.824	-0.368	1.69e-10	NS
THYM	Thymoma	2	120	5.558	6.208	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.015	6.181	0.129	0.301	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10
Autonomic ganglia	CHP212	10.6
Autonomic ganglia	IMR32	10.7
Autonomic ganglia	KELLY	10.8
Autonomic ganglia	KPNRTBM1	10.2
Autonomic ganglia	KPNSI9S	10.2
Autonomic ganglia	KPNYN	10.2
Autonomic ganglia	MHHNB11	10.2
Autonomic ganglia	NB1	10.5
Autonomic ganglia	NH6	10.3
Autonomic ganglia	SHSY5Y	9.8
Autonomic ganglia	SIMA	10.1
Autonomic ganglia	SKNAS	10.1
Autonomic ganglia	SKNBE2	10.5
Autonomic ganglia	SKNDZ	11.2
Autonomic ganglia	SKNFI	10.2
Autonomic ganglia	SKNSH	10.2
Biliary tract	HUCCT1	10.2
Biliary tract	HUH28	10
Biliary tract	SNU1079	10.2
Biliary tract	SNU1196	11.3
Biliary tract	SNU245	10.9
Biliary tract	SNU308	11.4
Biliary tract	SNU478	11.1
Bone	143B	11.4
Bone	A673	10.9
Bone	CADOES1	10.1
Bone	CAL78	10.5
Bone	G292CLONEA141B1	10.8
Bone	HOS	10.9
Bone	HS706T	9.8
Bone	HS737T	9.6
Bone	HS819T	9.4
Bone	HS821T	9.4
Bone	HS822T	9.3
Bone	HS863T	9.3
Bone	HS870T	9.8
Bone	HS888T	9.7
Bone	MG63	10.1
Bone	MHHES1	10.2
Bone	OUMS27	10.5
Bone	RDES	10
Bone	SJSA1	9.8
Bone	SKES1	10.6
Bone	SKNMC	10.9
Bone	SW1353	9.9
Bone	T173	9.7
Bone	TC71	11.5
Bone	U2OS	10.4
Breast	AU565	10.7
Breast	BT20	10.2
Breast	BT474	10.9
Breast	BT483	10.1
Breast	BT549	10.4
Breast	CAL120	10.3
Breast	CAL148	10.5
Breast	CAL51	10.1
Breast	CAL851	9.8
Breast	CAMA1	10.1
Breast	DU4475	10
Breast	EFM192A	10.6
Breast	EFM19	10.6
Breast	EVSAT	10.4
Breast	HCC1143	10.9
Breast	HCC1187	9.4
Breast	HCC1395	11
Breast	HCC1419	9.5
Breast	HCC1428	10.1
Breast	HCC1500	9.2
Breast	HCC1569	9.9
Breast	HCC1599	9.7
Breast	HCC1806	10
Breast	HCC1937	10.6
Breast	HCC1954	10.6
Breast	HCC202	10.8
Breast	HCC2157	10.1
Breast	HCC2218	10.6
Breast	HCC38	9.7
Breast	HCC70	10.4
Breast	HDQP1	9.4
Breast	HMC18	11.2
Breast	HS274T	9.2
Breast	HS281T	9.5
Breast	HS343T	9.7
Breast	HS578T	9.2
Breast	HS606T	9.7
Breast	HS739T	9.7
Breast	HS742T	9.4
Breast	JIMT1	9.9
Breast	KPL1	10.8
Breast	MCF7	10.9
Breast	MDAMB134VI	9.5
Breast	MDAMB157	10
Breast	MDAMB175VII	9.5
Breast	MDAMB231	10.5
Breast	MDAMB361	10.3
Breast	MDAMB415	9.8
Breast	MDAMB436	11
Breast	MDAMB453	10.4
Breast	MDAMB468	9.8
Breast	SKBR3	10.4
Breast	T47D	10
Breast	UACC812	9.5
Breast	UACC893	11.1
Breast	YMB1	10
Breast	ZR751	9.4
Breast	ZR7530	9.7
Central nervous system	1321N1	10.7
Central nervous system	42MGBA	10.9
Central nervous system	8MGBA	10.1
Central nervous system	A172	9.5
Central nervous system	AM38	10.3
Central nervous system	BECKER	9.8
Central nervous system	CAS1	10.6
Central nervous system	CCFSTTG1	10.1
Central nervous system	D283MED	11.2
Central nervous system	D341MED	10.6
Central nervous system	DAOY	11.2
Central nervous system	DBTRG05MG	9.2
Central nervous system	DKMG	8.1
Central nervous system	GAMG	10.5
Central nervous system	GB1	10.7
Central nervous system	GI1	10.1
Central nervous system	GMS10	10.7
Central nervous system	GOS3	8.6
Central nervous system	H4	10.2
Central nervous system	HS683	10.1
Central nervous system	KALS1	10
Central nervous system	KG1C	9.2
Central nervous system	KNS42	9.7
Central nervous system	KNS60	9.3
Central nervous system	KNS81	9.2
Central nervous system	KS1	10.2
Central nervous system	LN18	11
Central nervous system	LN229	9.9
Central nervous system	M059K	11.1
Central nervous system	MOGGCCM	9.1
Central nervous system	MOGGUVW	10.9
Central nervous system	NMCG1	9.7
Central nervous system	ONS76	10.6
Central nervous system	SF126	10.8
Central nervous system	SF295	10
Central nervous system	SNB19	9.5
Central nervous system	SNU1105	9.1
Central nervous system	SNU201	9.2
Central nervous system	SNU466	9.7
Central nervous system	SNU489	10.1
Central nervous system	SNU626	9.1
Central nervous system	SNU738	10.4
Central nervous system	SW1088	10.2
Central nervous system	SW1783	10.8
Central nervous system	T98G	9.6
Central nervous system	TM31	10.8
Central nervous system	U118MG	10.1
Central nervous system	U138MG	9.8
Central nervous system	U251MG	9.5
Central nervous system	U87MG	9.2
Central nervous system	YH13	10.3
Central nervous system	YKG1	9.7
Endometrium	AN3CA	10.6
Endometrium	COLO684	10.9
Endometrium	EFE184	10.6
Endometrium	EN	10.8
Endometrium	ESS1	10.7
Endometrium	HEC108	9.8
Endometrium	HEC151	11.2
Endometrium	HEC1A	10.6
Endometrium	HEC1B	10.5
Endometrium	HEC251	10.6
Endometrium	HEC265	10.8
Endometrium	HEC50B	11
Endometrium	HEC59	10.8
Endometrium	HEC6	11
Endometrium	ISHIKAWAHERAKLIO02ER	10.3
Endometrium	JHUEM1	10.5
Endometrium	JHUEM2	10.6
Endometrium	JHUEM3	10.1
Endometrium	KLE	11.3
Endometrium	MFE280	10.4
Endometrium	MFE296	10.8
Endometrium	MFE319	10.9
Endometrium	RL952	10.3
Endometrium	SNGM	10.7
Endometrium	SNU1077	10.3
Endometrium	SNU685	9.7
Endometrium	TEN	11.1
Haematopoietic and lymphoid	697	10.3
Haematopoietic and lymphoid	A3KAW	11
Haematopoietic and lymphoid	A4FUK	11.4
Haematopoietic and lymphoid	ALLSIL	10.3
Haematopoietic and lymphoid	AML193	10.1
Haematopoietic and lymphoid	AMO1	10.3
Haematopoietic and lymphoid	BCP1	11.1
Haematopoietic and lymphoid	BDCM	10.5
Haematopoietic and lymphoid	BL41	10.9
Haematopoietic and lymphoid	BL70	10.7
Haematopoietic and lymphoid	BV173	10.6
Haematopoietic and lymphoid	CA46	10.3
Haematopoietic and lymphoid	CI1	11.3
Haematopoietic and lymphoid	CMK115	10.2
Haematopoietic and lymphoid	CMK86	10.4
Haematopoietic and lymphoid	CMK	9.7
Haematopoietic and lymphoid	CMLT1	10.2
Haematopoietic and lymphoid	COLO775	10.4
Haematopoietic and lymphoid	DAUDI	9.7
Haematopoietic and lymphoid	DB	10.6
Haematopoietic and lymphoid	DEL	10.2
Haematopoietic and lymphoid	DND41	10.4
Haematopoietic and lymphoid	DOHH2	10.3
Haematopoietic and lymphoid	EB1	10.4
Haematopoietic and lymphoid	EB2	10.7
Haematopoietic and lymphoid	EHEB	9.7
Haematopoietic and lymphoid	EJM	10.7
Haematopoietic and lymphoid	EM2	10.2
Haematopoietic and lymphoid	EOL1	10.5
Haematopoietic and lymphoid	F36P	9.7
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	10
Haematopoietic and lymphoid	GRANTA519	9.9
Haematopoietic and lymphoid	HDLM2	10
Haematopoietic and lymphoid	HDMYZ	10.4
Haematopoietic and lymphoid	HEL9217	10.6
Haematopoietic and lymphoid	HEL	10.1
Haematopoietic and lymphoid	HH	10.5
Haematopoietic and lymphoid	HL60	10.7
Haematopoietic and lymphoid	HPBALL	10
Haematopoietic and lymphoid	HS604T	9.5
Haematopoietic and lymphoid	HS611T	10.4
Haematopoietic and lymphoid	HS616T	9.7
Haematopoietic and lymphoid	HS751T	9.2
Haematopoietic and lymphoid	HT	10.8
Haematopoietic and lymphoid	HTK	11
Haematopoietic and lymphoid	HUNS1	11.2
Haematopoietic and lymphoid	HUT102	9.9
Haematopoietic and lymphoid	HUT78	11.2
Haematopoietic and lymphoid	JEKO1	11.1
Haematopoietic and lymphoid	JK1	9.7
Haematopoietic and lymphoid	JM1	10.8
Haematopoietic and lymphoid	JURKAT	10.2
Haematopoietic and lymphoid	JURLMK1	10.4
Haematopoietic and lymphoid	JVM2	9.4
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	10.4
Haematopoietic and lymphoid	KARPAS299	9.6
Haematopoietic and lymphoid	KARPAS422	11.1
Haematopoietic and lymphoid	KARPAS620	10.6
Haematopoietic and lymphoid	KASUMI1	10.2
Haematopoietic and lymphoid	KASUMI2	10.6
Haematopoietic and lymphoid	KASUMI6	10.1
Haematopoietic and lymphoid	KCL22	10.2
Haematopoietic and lymphoid	KE37	9.6
Haematopoietic and lymphoid	KE97	10.7
Haematopoietic and lymphoid	KG1	10.5
Haematopoietic and lymphoid	KHM1B	10.5
Haematopoietic and lymphoid	KIJK	10.8
Haematopoietic and lymphoid	KMH2	9.3
Haematopoietic and lymphoid	KMM1	12.2
Haematopoietic and lymphoid	KMS11	10.2
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	10.3
Haematopoietic and lymphoid	KMS20	11.1
Haematopoietic and lymphoid	KMS21BM	10.5
Haematopoietic and lymphoid	KMS26	10.4
Haematopoietic and lymphoid	KMS27	10.7
Haematopoietic and lymphoid	KMS28BM	10.8
Haematopoietic and lymphoid	KMS34	10.4
Haematopoietic and lymphoid	KO52	10.4
Haematopoietic and lymphoid	KOPN8	10.7
Haematopoietic and lymphoid	KU812	11.3
Haematopoietic and lymphoid	KYO1	11.5
Haematopoietic and lymphoid	L1236	10.1
Haematopoietic and lymphoid	L363	9.8
Haematopoietic and lymphoid	L428	10.5
Haematopoietic and lymphoid	L540	9.1
Haematopoietic and lymphoid	LAMA84	10.3
Haematopoietic and lymphoid	LOUCY	10.5
Haematopoietic and lymphoid	LP1	9.4
Haematopoietic and lymphoid	M07E	10.6
Haematopoietic and lymphoid	MC116	10.5
Haematopoietic and lymphoid	ME1	10.9
Haematopoietic and lymphoid	MEC1	9.8
Haematopoietic and lymphoid	MEC2	10.9
Haematopoietic and lymphoid	MEG01	11.5
Haematopoietic and lymphoid	MHHCALL2	10.4
Haematopoietic and lymphoid	MHHCALL3	10.3
Haematopoietic and lymphoid	MHHCALL4	10.5
Haematopoietic and lymphoid	MINO	10.7
Haematopoietic and lymphoid	MJ	10.8
Haematopoietic and lymphoid	MM1S	9.3
Haematopoietic and lymphoid	MOLM13	10.6
Haematopoietic and lymphoid	MOLM16	10.6
Haematopoietic and lymphoid	MOLM6	10.7
Haematopoietic and lymphoid	MOLP2	10.2
Haematopoietic and lymphoid	MOLP8	10.2
Haematopoietic and lymphoid	MOLT13	9.7
Haematopoietic and lymphoid	MOLT16	9.4
Haematopoietic and lymphoid	MOLT4	10.1
Haematopoietic and lymphoid	MONOMAC1	10
Haematopoietic and lymphoid	MONOMAC6	10.8
Haematopoietic and lymphoid	MOTN1	9.3
Haematopoietic and lymphoid	MUTZ5	10.1
Haematopoietic and lymphoid	MV411	10.3
Haematopoietic and lymphoid	NALM19	11.1
Haematopoietic and lymphoid	NALM1	10.4
Haematopoietic and lymphoid	NALM6	10.4
Haematopoietic and lymphoid	NAMALWA	10.6
Haematopoietic and lymphoid	NB4	10.5
Haematopoietic and lymphoid	NCIH929	10.5
Haematopoietic and lymphoid	NCO2	10.8
Haematopoietic and lymphoid	NOMO1	9.6
Haematopoietic and lymphoid	NUDHL1	11.5
Haematopoietic and lymphoid	NUDUL1	10.8
Haematopoietic and lymphoid	OCIAML2	10
Haematopoietic and lymphoid	OCIAML3	10.7
Haematopoietic and lymphoid	OCIAML5	10.3
Haematopoietic and lymphoid	OCILY10	11.8
Haematopoietic and lymphoid	OCILY19	11.1
Haematopoietic and lymphoid	OCILY3	11
Haematopoietic and lymphoid	OCIM1	9.7
Haematopoietic and lymphoid	OPM2	9.6
Haematopoietic and lymphoid	P12ICHIKAWA	9.9
Haematopoietic and lymphoid	P31FUJ	10.3
Haematopoietic and lymphoid	P3HR1	10.8
Haematopoietic and lymphoid	PCM6	10.3
Haematopoietic and lymphoid	PEER	11.1
Haematopoietic and lymphoid	PF382	8.9
Haematopoietic and lymphoid	PFEIFFER	10.6
Haematopoietic and lymphoid	PL21	9.5
Haematopoietic and lymphoid	RAJI	11.2
Haematopoietic and lymphoid	RCHACV	10.6
Haematopoietic and lymphoid	REC1	10.8
Haematopoietic and lymphoid	REH	11.2
Haematopoietic and lymphoid	RI1	10.5
Haematopoietic and lymphoid	RL	10.8
Haematopoietic and lymphoid	RPMI8226	10.3
Haematopoietic and lymphoid	RPMI8402	10
Haematopoietic and lymphoid	RS411	10.7
Haematopoietic and lymphoid	SEM	10.7
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	10.6
Haematopoietic and lymphoid	SKM1	10.7
Haematopoietic and lymphoid	SKMM2	10.4
Haematopoietic and lymphoid	SR786	8.5
Haematopoietic and lymphoid	ST486	11
Haematopoietic and lymphoid	SUDHL10	10.5
Haematopoietic and lymphoid	SUDHL1	10.1
Haematopoietic and lymphoid	SUDHL4	10.1
Haematopoietic and lymphoid	SUDHL5	10.3
Haematopoietic and lymphoid	SUDHL6	9.8
Haematopoietic and lymphoid	SUDHL8	10.5
Haematopoietic and lymphoid	SUPB15	10.8
Haematopoietic and lymphoid	SUPHD1	10.6
Haematopoietic and lymphoid	SUPM2	8.9
Haematopoietic and lymphoid	SUPT11	9.9
Haematopoietic and lymphoid	SUPT1	11.1
Haematopoietic and lymphoid	TALL1	10.3
Haematopoietic and lymphoid	TF1	10.7
Haematopoietic and lymphoid	THP1	10.6
Haematopoietic and lymphoid	TO175T	9.8
Haematopoietic and lymphoid	TOLEDO	10.9
Haematopoietic and lymphoid	U266B1	10.6
Haematopoietic and lymphoid	U937	10
Haematopoietic and lymphoid	UT7	9.6
Haematopoietic and lymphoid	WSUDLCL2	9.6
Kidney	769P	9.5
Kidney	786O	9.5
Kidney	A498	9.5
Kidney	A704	8.1
Kidney	ACHN	10.3
Kidney	BFTC909	9.3
Kidney	CAKI1	9.7
Kidney	CAKI2	9.8
Kidney	CAL54	9.9
Kidney	KMRC1	9
Kidney	KMRC20	9.3
Kidney	KMRC2	9.1
Kidney	KMRC3	9.7
Kidney	OSRC2	9.7
Kidney	RCC10RGB	9.1
Kidney	SNU1272	9.3
Kidney	SNU349	9.5
Kidney	TUHR10TKB	9.6
Kidney	TUHR14TKB	9.4
Kidney	TUHR4TKB	9.2
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	9.2
Large intestine	C2BBE1	10.2
Large intestine	CCK81	11.2
Large intestine	CL11	10.9
Large intestine	CL14	10.1
Large intestine	CL34	10.5
Large intestine	CL40	11.2
Large intestine	COLO205	10.9
Large intestine	COLO320	11
Large intestine	COLO678	9.3
Large intestine	CW2	11.4
Large intestine	DLD1	10.6
Large intestine	GP2D	10.2
Large intestine	HCC56	10.5
Large intestine	HCT116	11.5
Large intestine	HCT15	11.2
Large intestine	HS675T	9.9
Large intestine	HS698T	9.9
Large intestine	HT115	11.2
Large intestine	HT29	9.7
Large intestine	HT55	9.9
Large intestine	KM12	10.4
Large intestine	LOVO	10.7
Large intestine	LS1034	10.5
Large intestine	LS123	11.2
Large intestine	LS180	10.6
Large intestine	LS411N	10.3
Large intestine	LS513	10.1
Large intestine	MDST8	10.3
Large intestine	NCIH508	9.6
Large intestine	NCIH716	10.9
Large intestine	NCIH747	10.1
Large intestine	OUMS23	10.8
Large intestine	RCM1	11.2
Large intestine	RKO	10.2
Large intestine	SKCO1	10.8
Large intestine	SNU1040	10.9
Large intestine	SNU1197	10.8
Large intestine	SNU175	10.4
Large intestine	SNU283	10.2
Large intestine	SNU407	11.1
Large intestine	SNU503	11.3
Large intestine	SNU61	11.1
Large intestine	SNU81	11.3
Large intestine	SNUC1	10.8
Large intestine	SNUC2A	10.4
Large intestine	SNUC4	10.6
Large intestine	SNUC5	11.1
Large intestine	SW1116	11
Large intestine	SW1417	10.8
Large intestine	SW1463	10.9
Large intestine	SW403	9.9
Large intestine	SW480	10.5
Large intestine	SW48	10.8
Large intestine	SW620	10.9
Large intestine	SW837	10.3
Large intestine	SW948	10
Large intestine	T84	10.5
Liver	ALEXANDERCELLS	9.9
Liver	C3A	9.8
Liver	HEP3B217	10
Liver	HEPG2	11.3
Liver	HLE	10.7
Liver	HLF	10.9
Liver	HUH1	10.8
Liver	HUH6	10.4
Liver	HUH7	11
Liver	JHH1	10.2
Liver	JHH2	10.2
Liver	JHH4	10.3
Liver	JHH5	10.5
Liver	JHH6	9.4
Liver	JHH7	10.9
Liver	LI7	10.9
Liver	PLCPRF5	10.3
Liver	SKHEP1	10.3
Liver	SNU182	10.4
Liver	SNU387	9.6
Liver	SNU398	11.1
Liver	SNU423	10.6
Liver	SNU449	10.6
Liver	SNU475	10.1
Liver	SNU761	9.7
Liver	SNU878	11
Liver	SNU886	10
Lung	A549	10.8
Lung	ABC1	9.4
Lung	BEN	9.2
Lung	CAL12T	11.7
Lung	CALU1	10.7
Lung	CALU3	10.4
Lung	CALU6	10.4
Lung	CHAGOK1	9.7
Lung	COLO668	10.6
Lung	COLO699	9.4
Lung	CORL105	10.2
Lung	CORL23	11.7
Lung	CORL24	9.5
Lung	CORL279	10.5
Lung	CORL311	10
Lung	CORL47	10.3
Lung	CORL51	9.4
Lung	CORL88	10.6
Lung	CORL95	9.8
Lung	CPCN	10.7
Lung	DMS114	10.8
Lung	DMS153	9.9
Lung	DMS273	11
Lung	DMS454	9.6
Lung	DMS53	10.4
Lung	DMS79	11.1
Lung	DV90	11.3
Lung	EBC1	10
Lung	EPLC272H	10.9
Lung	HARA	10.6
Lung	HCC1171	10.2
Lung	HCC1195	11.5
Lung	HCC15	9.9
Lung	HCC2279	10.8
Lung	HCC2935	10.3
Lung	HCC33	10.5
Lung	HCC366	9.8
Lung	HCC4006	9.6
Lung	HCC44	11.1
Lung	HCC78	10.4
Lung	HCC827	11.2
Lung	HCC95	10.3
Lung	HLC1	10.6
Lung	HLFA	9.9
Lung	HS229T	10.2
Lung	HS618T	10.2
Lung	IALM	10.7
Lung	KNS62	11.3
Lung	LC1F	10.1
Lung	LC1SQSF	9.6
Lung	LCLC103H	10.1
Lung	LCLC97TM1	10.5
Lung	LK2	10.7
Lung	LOUNH91	9.3
Lung	LU65	10.6
Lung	LU99	11
Lung	LUDLU1	10.7
Lung	LXF289	10.6
Lung	MORCPR	10.3
Lung	NCIH1048	10.8
Lung	NCIH1092	9.9
Lung	NCIH1105	9.8
Lung	NCIH1155	10.3
Lung	NCIH1184	10.6
Lung	NCIH1299	10.9
Lung	NCIH1339	9.8
Lung	NCIH1341	11.1
Lung	NCIH1355	11.1
Lung	NCIH1373	10.8
Lung	NCIH1385	9.2
Lung	NCIH1395	10.1
Lung	NCIH1435	11
Lung	NCIH1436	9.3
Lung	NCIH1437	10.1
Lung	NCIH146	10.5
Lung	NCIH1563	9.9
Lung	NCIH1568	10.7
Lung	NCIH1573	10.8
Lung	NCIH1581	10.9
Lung	NCIH1618	10.2
Lung	NCIH1623	10.6
Lung	NCIH1648	11.3
Lung	NCIH1650	9
Lung	NCIH1651	11.4
Lung	NCIH1666	10.6
Lung	NCIH1693	10.6
Lung	NCIH1694	10.8
Lung	NCIH1703	10.8
Lung	NCIH1734	10.7
Lung	NCIH1755	10.4
Lung	NCIH1781	11.4
Lung	NCIH1792	11.5
Lung	NCIH1793	10.4
Lung	NCIH1836	10.3
Lung	NCIH1838	11.2
Lung	NCIH1869	10.2
Lung	NCIH1876	9.3
Lung	NCIH1915	10.4
Lung	NCIH1930	11
Lung	NCIH1944	10
Lung	NCIH1963	10.1
Lung	NCIH196	10.8
Lung	NCIH1975	10.1
Lung	NCIH2009	10
Lung	NCIH2023	10.6
Lung	NCIH2029	12.3
Lung	NCIH2030	11.1
Lung	NCIH2066	11.3
Lung	NCIH2081	9.6
Lung	NCIH2085	10.8
Lung	NCIH2087	11.6
Lung	NCIH209	10.5
Lung	NCIH2106	10.9
Lung	NCIH2110	9.9
Lung	NCIH211	10.6
Lung	NCIH2122	11.1
Lung	NCIH2126	10.2
Lung	NCIH2141	10.8
Lung	NCIH2170	11.1
Lung	NCIH2171	12.1
Lung	NCIH2172	10.7
Lung	NCIH2196	9.5
Lung	NCIH2227	9.7
Lung	NCIH2228	10.2
Lung	NCIH226	11.1
Lung	NCIH2286	10.8
Lung	NCIH2291	10
Lung	NCIH2342	10.6
Lung	NCIH2347	11.1
Lung	NCIH23	11.7
Lung	NCIH2405	10.5
Lung	NCIH2444	10.8
Lung	NCIH292	10.5
Lung	NCIH322	11.7
Lung	NCIH3255	10.8
Lung	NCIH358	11.3
Lung	NCIH441	10.3
Lung	NCIH446	10.3
Lung	NCIH460	11.3
Lung	NCIH510	10.5
Lung	NCIH520	10.8
Lung	NCIH522	10.7
Lung	NCIH524	11.8
Lung	NCIH526	10.5
Lung	NCIH596	9.8
Lung	NCIH647	10.2
Lung	NCIH650	11.2
Lung	NCIH661	11
Lung	NCIH69	10.9
Lung	NCIH727	10.4
Lung	NCIH810	10.8
Lung	NCIH82	10.8
Lung	NCIH838	10
Lung	NCIH841	10.7
Lung	NCIH854	9.9
Lung	NCIH889	10.1
Lung	PC14	9.7
Lung	RERFLCAD1	10.5
Lung	RERFLCAD2	11.3
Lung	RERFLCAI	10.8
Lung	RERFLCKJ	9.6
Lung	RERFLCMS	10.3
Lung	RERFLCSQ1	9.1
Lung	SBC5	9.8
Lung	SCLC21H	10.3
Lung	SHP77	11.4
Lung	SKLU1	11.1
Lung	SKMES1	10.2
Lung	SQ1	10.4
Lung	SW1271	11.4
Lung	SW1573	9.9
Lung	SW900	10.2
Lung	VMRCLCD	10.7
Lung	VMRCLCP	10.6
Oesophagus	COLO680N	10.1
Oesophagus	ECGI10	11.4
Oesophagus	KYSE140	11.1
Oesophagus	KYSE150	9.9
Oesophagus	KYSE180	12.2
Oesophagus	KYSE270	9.8
Oesophagus	KYSE30	8.6
Oesophagus	KYSE410	10.4
Oesophagus	KYSE450	10.6
Oesophagus	KYSE510	10.6
Oesophagus	KYSE520	10
Oesophagus	KYSE70	10.1
Oesophagus	OE19	10.1
Oesophagus	OE33	9.8
Oesophagus	TE10	11.9
Oesophagus	TE11	11.4
Oesophagus	TE14	10
Oesophagus	TE15	11.2
Oesophagus	TE1	10.4
Oesophagus	TE4	10.6
Oesophagus	TE5	9.5
Oesophagus	TE6	11.1
Oesophagus	TE8	10.4
Oesophagus	TE9	11.2
Oesophagus	TT	11
Ovary	59M	11
Ovary	A2780	11
Ovary	CAOV3	10.5
Ovary	CAOV4	10.3
Ovary	COLO704	11
Ovary	COV318	10.9
Ovary	COV362	9.1
Ovary	COV434	9.8
Ovary	COV504	10
Ovary	COV644	8.6
Ovary	EFO21	10
Ovary	EFO27	10.5
Ovary	ES2	10.8
Ovary	FUOV1	11.1
Ovary	HEYA8	11
Ovary	HS571T	9.3
Ovary	IGROV1	11
Ovary	JHOC5	10.9
Ovary	JHOM1	11.2
Ovary	JHOM2B	9.6
Ovary	JHOS2	9.4
Ovary	JHOS4	11.4
Ovary	KURAMOCHI	10.1
Ovary	MCAS	11.7
Ovary	NIHOVCAR3	9.8
Ovary	OAW28	9.5
Ovary	OAW42	10.6
Ovary	OC314	10.8
Ovary	OC316	11.2
Ovary	ONCODG1	9.7
Ovary	OV56	10.2
Ovary	OV7	10.8
Ovary	OV90	10
Ovary	OVCAR4	10
Ovary	OVCAR8	10.9
Ovary	OVISE	10.2
Ovary	OVK18	11
Ovary	OVKATE	10.2
Ovary	OVMANA	8.9
Ovary	OVSAHO	10
Ovary	OVTOKO	10.5
Ovary	RMGI	10.5
Ovary	RMUGS	10.9
Ovary	SKOV3	10
Ovary	SNU119	10.9
Ovary	SNU840	11.3
Ovary	SNU8	11
Ovary	TOV112D	10.6
Ovary	TOV21G	9.8
Ovary	TYKNU	10.6
Pancreas	ASPC1	9.3
Pancreas	BXPC3	11
Pancreas	CAPAN1	10.9
Pancreas	CAPAN2	10.7
Pancreas	CFPAC1	10.4
Pancreas	DANG	11.3
Pancreas	HPAC	9.9
Pancreas	HPAFII	11.1
Pancreas	HS766T	10.3
Pancreas	HUPT3	11.4
Pancreas	HUPT4	10.6
Pancreas	KCIMOH1	9.8
Pancreas	KLM1	10.6
Pancreas	KP2	9.4
Pancreas	KP3	9.1
Pancreas	KP4	11.1
Pancreas	L33	10.2
Pancreas	MIAPACA2	10.7
Pancreas	PANC0203	10.6
Pancreas	PANC0213	10.2
Pancreas	PANC0327	11
Pancreas	PANC0403	10.4
Pancreas	PANC0504	10.6
Pancreas	PANC0813	10.6
Pancreas	PANC1005	9.7
Pancreas	PANC1	10.6
Pancreas	PATU8902	10.7
Pancreas	PATU8988S	9.8
Pancreas	PATU8988T	10.8
Pancreas	PK1	10.7
Pancreas	PK45H	10.1
Pancreas	PK59	11
Pancreas	PL45	10
Pancreas	PSN1	11.1
Pancreas	QGP1	9.4
Pancreas	SNU213	10.8
Pancreas	SNU324	11.1
Pancreas	SNU410	10.1
Pancreas	SU8686	10.2
Pancreas	SUIT2	9.5
Pancreas	SW1990	11.3
Pancreas	T3M4	10.6
Pancreas	TCCPAN2	9.5
Pancreas	YAPC	10.1
Pleura	ACCMESO1	10.1
Pleura	DM3	10.2
Pleura	ISTMES1	10.5
Pleura	ISTMES2	10.8
Pleura	JL1	10.2
Pleura	MPP89	10.7
Pleura	MSTO211H	11.1
Pleura	NCIH2052	9.8
Pleura	NCIH2452	10.1
Pleura	NCIH28	9.9
Prostate	22RV1	10.8
Prostate	DU145	10.7
Prostate	LNCAPCLONEFGC	10.6
Prostate	MDAPCA2B	10.5
Prostate	NCIH660	10.7
Prostate	PC3	10.9
Prostate	VCAP	10.1
Salivary gland	A253	9.8
Salivary gland	YD15	11.3
Skin	A101D	10.3
Skin	A2058	10.2
Skin	A375	10.4
Skin	C32	10.1
Skin	CHL1	10.3
Skin	CJM	11.1
Skin	COLO679	10
Skin	COLO741	9.6
Skin	COLO783	10.3
Skin	COLO792	9.4
Skin	COLO800	9.8
Skin	COLO818	9.4
Skin	COLO829	10.1
Skin	COLO849	10.5
Skin	G361	10.5
Skin	GRM	11.1
Skin	HMCB	10.6
Skin	HS294T	9.6
Skin	HS600T	9.7
Skin	HS688AT	9.5
Skin	HS695T	9.7
Skin	HS839T	9.8
Skin	HS852T	9.8
Skin	HS895T	9.5
Skin	HS934T	9.5
Skin	HS936T	10.1
Skin	HS939T	10.4
Skin	HS940T	9.7
Skin	HS944T	10.5
Skin	HT144	10.8
Skin	IGR1	9.8
Skin	IGR37	10.1
Skin	IGR39	10.3
Skin	IPC298	10.1
Skin	K029AX	9.6
Skin	LOXIMVI	10.8
Skin	MALME3M	9.7
Skin	MDAMB435S	8.9
Skin	MELHO	10.5
Skin	MELJUSO	10.5
Skin	MEWO	10.1
Skin	RPMI7951	9.7
Skin	RVH421	10.1
Skin	SH4	10.2
Skin	SKMEL1	10
Skin	SKMEL24	9.6
Skin	SKMEL28	9.8
Skin	SKMEL2	10.5
Skin	SKMEL30	10.1
Skin	SKMEL31	9.3
Skin	SKMEL3	10.1
Skin	SKMEL5	10.2
Skin	UACC257	10.4
Skin	UACC62	11
Skin	WM115	10
Skin	WM1799	10
Skin	WM2664	10
Skin	WM793	9.6
Skin	WM88	9.7
Skin	WM983B	9.6
Small intestine	HUTU80	10.5
Soft tissue	A204	10.5
Soft tissue	G401	11
Soft tissue	G402	10.6
Soft tissue	GCT	11
Soft tissue	HS729	10.4
Soft tissue	HT1080	10.8
Soft tissue	KYM1	10.8
Soft tissue	MESSA	10.6
Soft tissue	RD	10.3
Soft tissue	RH30	11.4
Soft tissue	RH41	11.2
Soft tissue	RKN	11.2
Soft tissue	S117	10.6
Soft tissue	SJRH30	10.7
Soft tissue	SKLMS1	10.8
Soft tissue	SKUT1	11.4
Soft tissue	TE125T	9.2
Soft tissue	TE159T	9.6
Soft tissue	TE441T	10.2
Soft tissue	TE617T	10.6
Stomach	2313287	10.2
Stomach	AGS	10.8
Stomach	AZ521	10.8
Stomach	ECC10	10.3
Stomach	ECC12	10.9
Stomach	FU97	9.5
Stomach	GCIY	10.7
Stomach	GSS	10.1
Stomach	GSU	11.2
Stomach	HGC27	11.2
Stomach	HS746T	11.2
Stomach	HUG1N	10.3
Stomach	IM95	11
Stomach	KATOIII	10.5
Stomach	KE39	10.2
Stomach	LMSU	11.2
Stomach	MKN1	10
Stomach	MKN45	11.1
Stomach	MKN74	10.9
Stomach	MKN7	11.6
Stomach	NCCSTCK140	9.8
Stomach	NCIN87	9.6
Stomach	NUGC2	10.6
Stomach	NUGC3	11
Stomach	NUGC4	9.8
Stomach	OCUM1	11
Stomach	RERFGC1B	10.8
Stomach	SH10TC	10.9
Stomach	SNU16	11.1
Stomach	SNU1	11
Stomach	SNU216	9.9
Stomach	SNU520	10.3
Stomach	SNU5	10.3
Stomach	SNU601	10.7
Stomach	SNU620	10.2
Stomach	SNU668	10.3
Stomach	SNU719	10.4
Stomach	TGBC11TKB	10.1
Thyroid	8305C	10.8
Thyroid	8505C	11
Thyroid	BCPAP	10.6
Thyroid	BHT101	10.3
Thyroid	CAL62	10.5
Thyroid	CGTHW1	10
Thyroid	FTC133	11.1
Thyroid	FTC238	10.3
Thyroid	ML1	10.7
Thyroid	SW579	10.5
Thyroid	TT2609C02	11
Thyroid	TT	9.6
Upper aerodigestive tract	BHY	9.8
Upper aerodigestive tract	BICR16	11.3
Upper aerodigestive tract	BICR18	10.9
Upper aerodigestive tract	BICR22	9.8
Upper aerodigestive tract	BICR31	9.5
Upper aerodigestive tract	BICR56	10.4
Upper aerodigestive tract	BICR6	11.1
Upper aerodigestive tract	CAL27	10.1
Upper aerodigestive tract	CAL33	9.4
Upper aerodigestive tract	DETROIT562	10.9
Upper aerodigestive tract	FADU	10.8
Upper aerodigestive tract	HS840T	10.2
Upper aerodigestive tract	HSC2	10
Upper aerodigestive tract	HSC3	11.6
Upper aerodigestive tract	HSC4	10
Upper aerodigestive tract	PECAPJ15	9.7
Upper aerodigestive tract	PECAPJ34CLONEC12	11
Upper aerodigestive tract	PECAPJ41CLONED2	10.5
Upper aerodigestive tract	PECAPJ49	10.7
Upper aerodigestive tract	SCC15	10.2
Upper aerodigestive tract	SCC25	11
Upper aerodigestive tract	SCC4	10.2
Upper aerodigestive tract	SCC9	10
Upper aerodigestive tract	SNU1076	8.9
Upper aerodigestive tract	SNU1214	10.7
Upper aerodigestive tract	SNU46	11.4
Upper aerodigestive tract	SNU899	10.1
Upper aerodigestive tract	YD10B	10.3
Upper aerodigestive tract	YD38	10.6
Upper aerodigestive tract	YD8	10.3
Urinary tract	5637	11.2
Urinary tract	639V	11.5
Urinary tract	647V	10.2
Urinary tract	BC3C	11
Urinary tract	BFTC905	11
Urinary tract	CAL29	10.1
Urinary tract	HS172T	9
Urinary tract	HT1197	10.9
Urinary tract	HT1376	10.2
Urinary tract	J82	10.7
Urinary tract	JMSU1	10.9
Urinary tract	KMBC2	10.7
Urinary tract	KU1919	10.4
Urinary tract	RT11284	10.3
Urinary tract	RT112	10.3
Urinary tract	RT4	10.4
Urinary tract	SCABER	10.2
Urinary tract	SW1710	9
Urinary tract	SW780	10.4
Urinary tract	T24	10.6
Urinary tract	TCCSUP	9.5
Urinary tract	UMUC1	10.1
Urinary tract	UMUC3	10.9
Urinary tract	VMCUB1	10

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	27.8
Adrenal gland	32.8
Appendix	41.2
Bone marrow	13.9
Breast	40
Cerebral cortex	42.7
Cervix, uterine	39.2
Colon	40.1
Duodenum	26.4
Endometrium	54.5
Epididymis	34.6
Esophagus	48.6
Fallopian tube	67.1
Gallbladder	30.2
Heart muscle	16.9
Kidney	38.9
Liver	12.2
Lung	29
Lymph node	31
Ovary	54.4
Pancreas	5.4
Parathyroid gland	71.4
Placenta	40.9
Prostate	43.2
Rectum	38.2
Salivary gland	11.9
Seminal vesicle	43.4
Skeletal muscle	16.6
Skin	40
Small intestine	22.5
Smooth muscle	49.1
Spleen	28
Stomach	23.6
Testis	55.4
Thyroid gland	58.9
Tonsil	30.7
Urinary bladder	29.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27546619	Overexpression	Prostate Carcinoma	Furthermore, PRMT5 expression in prostate cancer tissues is significantly higher than that in benign prostatic hyperplasia tissues, and PRMT5 expression correlates positively with AR expression at both the protein and mRNA levels.
27315569	Overexpression	Gastric Carcinoma	PRMT5 mRNA levels were significantly higher in GC tissues than the corresponding adjacent normal tissues and were independent of tumour depth, differentiation and lymph node metastasis.
26541651	Overexpression	Hepatocellular Carcinoma	PRMT5 expression was markedly upregulated in HCC tissues, and correlated inversely with overall patient survival.
26248553	altered expression	Colorectal Carcinoma	Early CRC (55 of 68, 80.9%) showed more frequent nuclear expression of PRMT5 than adenoma (15 of 40, 37.5%) (P < 0.001).
25704480	altered expression	Breast Carcinoma	We examined TRAF4 and PRMT5 expression by immunohistochemistry and found that their expression is positively correlated in breast cancer.
24775604	Aberrant Expression	Lung Adenocarcinoma	Immunohistochemical analysis of lung adenocarcinoma cases (n = 130) revealed that the expression of PRMT5 was high in the cytoplasm of 47 cases (36%) and the nuclei of 34 cases (26%).
24098663	Overexpression	Melanoma	Immunohistochemical analysis indicated significant upregulation of PRMT5 in human melanocytic nevi, malignant melanomas and metastatic melanomas as compared to normal epidermis.
23292799	Overexpression	Endometrial Carcinoma	PRMT5 overexpression was observed in 83.1% (98/118) of EOCs, and it was significantly associated with serous type, poor differentiation, advanced tumor stage, lymph node invasion, presence of residual tumor, and high expression of Ki-67 (p<0.05, respectively).
28591716	Overexpression	Pancreatic Ductal Adenocarcinoma; Colorectal Carcinoma	Here, we show that PRMT5 is highly expressed in PDAC and CRC.
28107179	Overexpression	Oropharyngeal Squamous Cell Carcinoma	Nuclear PRMT5 expression was inversely correlated with p16-status (p < 0.001) and was significantly higher in tumor samples from patients who smoked > 10 pack-years (p = 0.013).
28101581	Overexpression	Hepatocellular Carcinoma	Although the level of PRMT5 mRNA was not influenced by patient's background liver status, it was significantly higher in HCC tissues than in the corresponding noncancerous tissues.
27708221	Overexpression	Hepatocellular Carcinoma	Upregulation of both PRMT5 and CDK4 predicts more malignant characteristics in human HCC tissues.
27546619	Overexpression	Prostate Carcinoma	Furthermore, PRMT5 expression in prostate cancer tissues is significantly higher than that in benign prostatic hyperplasia tissues, and PRMT5 expression correlates positively with AR expression at both the protein and mRNA levels.

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.531	8e-31	28.7	50.7	20.5	Neutral
BRCA	Breast invasive carcinoma	1075	0.594	1.11e-103	22.3	59.8	17.9	Neutral
CESC	Cervical and endocervical cancers	292	0.541	1.49e-23	11	72.9	16.1	Neutral
COAD	Colon adenocarcinoma	449	0.665	1.02e-58	31.6	60.1	8.2	Neutral
ESCA	Esophageal carcinoma	183	0.533	8.28e-15	27.3	43.7	29	Neutral
GBM	Glioblastoma multiforme	147	0.699	7.21e-23	37.4	57.8	4.8	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.659	2.04e-65	14.8	56.4	28.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.556	5.08e-44	38.9	57.9	3.2	Loss
KIRP	Kidney renal papillary cell carcinoma	288	0.438	6.31e-15	17.4	81.9	0.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.126	0.107	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.591	1.29e-49	13.3	84.4	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.4	2.2e-15	21.4	68.4	10.2	Neutral
LUAD	Lung adenocarcinoma	512	0.634	6.55e-59	19.7	47.5	32.8	Neutral
LUSC	Lung squamous cell carcinoma	498	0.632	7.6e-57	34.5	36.9	28.5	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.787	1.68e-64	33.7	45	21.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.334	5.71e-06	9.6	73.4	16.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.324	2.6e-05	13	85.2	1.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.27	1.19e-09	6.7	91.4	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.61	4.28e-18	40.2	54.3	5.5	Loss
SARC	Sarcoma	255	0.638	1.62e-30	20.4	49.8	29.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.561	7.08e-32	30.5	57.8	11.7	Neutral
STAD	Stomach adenocarcinoma	413	0.451	4.71e-22	25.4	62.7	11.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.196	0.0164	13.3	52.7	34	Gain
THCA	Thyroid carcinoma	497	0.219	8.19e-07	0.2	97.6	2.2	Neutral
THYM	Thymoma	119	0.259	0.00449	1.7	86.6	11.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.348	9.85e-17	10.6	79.5	9.9	Neutral

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.327	5.89e-12	17	408	-0.003	0.567	NS/NA
BRCA	Breast invasive carcinoma	-0.208	7.16e-10	83	785	0	0.155	NS/NA
CESC	Cervical and endocervical cancers	-0.213	0.000166	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.209	0.00019	19	297	0.01	3.27e-05	NS/NA
ESCA	Esophageal carcinoma	-0.225	0.00166	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.19	0.129	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.221	2.12e-07	20	522	-0.009	0.101	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.318	1.96e-09	24	319	0.007	0.0394	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.259	6.29e-06	23	275	0.005	4.67e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.128	0.0958	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.232	7.5e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.155	0.00161	41	373	0.003	0.00432	NS/NA
LUAD	Lung adenocarcinoma	-0.19	2.94e-05	21	456	-0.019	0.67	NS/NA
LUSC	Lung squamous cell carcinoma	-0.356	1.35e-12	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.783	0.0172	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.246	0.00081	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.239	0.00101	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.138	0.00145	35	498	0	0.378	NS/NA
READ	Rectum adenocarcinoma	-0.254	0.0105	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.37	8.29e-10	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.344	2e-14	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.161	0.00189	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.237	0.00294	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.08	0.0582	50	509	-0.003	0.03	NS/NA
THYM	Thymoma	-0.136	0.134	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.216	2.63e-06	34	431	-0.001	0.377	NS/NA

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	0	Not detected
Breast	0	Not detected
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	1	Low
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	3	High
Kidney	2	Medium
Liver	1	Low
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	3	High
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	1	Low

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.215	NS	24476821
BRCA	Breast invasive carcinoma	521	1.53e-07	Significant	23000897
COAD	Colon adenocarcinoma	149	5.61e-06	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00741	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00168	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00961	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.46e-28	Significant	26824661
LUAD	Lung adenocarcinoma	230	3.68e-09	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00255	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	6.89e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0263	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0283	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00641	Significant	26091043
STAD	Stomach adenocarcinoma	277	9.16e-11	Significant	25079317
THCA	Thyroid carcinoma	391	0.000218	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0118	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.773	0.00846	Shorter
BRCA	Breast invasive carcinoma	1079	1.119	0.603	NS
CESC	Cervical and endocervical cancers	291	1.824	0.0954	NS
COAD	Colon adenocarcinoma	439	0.875	0.645	NS
ESCA	Esophageal carcinoma	184	0.883	0.709	NS
GBM	Glioblastoma multiforme	158	0.54	0.0183	Longer
HNSC	Head and Neck squamous cell carcinoma	518	2.311	3.81e-05	Shorter
KIRC	Kidney renal clear cell carcinoma	531	0.537	0.00317	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.735	0.528	NS
LAML	Acute Myeloid Leukemia	149	0.917	0.758	NS
LGG	Brain Lower Grade Glioma	511	0.331	4.56e-06	Longer
LIHC	Liver hepatocellular carcinoma	365	1.619	0.0528	NS
LUAD	Lung adenocarcinoma	502	1.351	0.144	NS
LUSC	Lung squamous cell carcinoma	494	0.703	0.078	NS
OV	Ovarian serous cystadenocarcinoma	303	0.885	0.561	NS
PAAD	Pancreatic adenocarcinoma	177	2.358	0.00381	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	665828523.971	0.136	NS
PRAD	Prostate adenocarcinoma	497	2.114	0.517	NS
READ	Rectum adenocarcinoma	159	0.605	0.404	NS
SARC	Sarcoma	259	2.651	0.0013	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.274	0.218	NS
STAD	Stomach adenocarcinoma	388	0.809	0.34	NS
TGCT	Testicular Germ Cell Tumors	134	555722859.158	0.334	NS
THCA	Thyroid carcinoma	500	1.545	0.549	NS
THYM	Thymoma	119	1.035	0.967	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.523	0.156	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.008	0.878	NS
BRCA	Breast invasive carcinoma	1071	0.052	0.0907	NS
CESC	Cervical and endocervical cancers	167	0.045	0.567	NS
COAD	Colon adenocarcinoma	445	-0.128	0.00671	Lower
ESCA	Esophageal carcinoma	162	-0.007	0.925	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.067	0.155	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.253	3.61e-09	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.121	0.0511	NS
LIHC	Liver hepatocellular carcinoma	347	0.041	0.449	NS
LUAD	Lung adenocarcinoma	507	0.075	0.0914	NS
LUSC	Lung squamous cell carcinoma	497	0.12	0.00725	Higher
OV	Ovarian serous cystadenocarcinoma	302	0.003	0.962	NS
PAAD	Pancreatic adenocarcinoma	176	0.109	0.149	NS
READ	Rectum adenocarcinoma	156	-0.105	0.191	NS
SKCM	Skin Cutaneous Melanoma	410	-0.079	0.112	NS
STAD	Stomach adenocarcinoma	392	0.001	0.988	NS
TGCT	Testicular Germ Cell Tumors	81	0.06	0.593	NS
THCA	Thyroid carcinoma	499	0.047	0.296	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.054	0.225	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.111	0.0688	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.073	0.103	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.22	3.48e-07	Lower
LGG	Brain Lower Grade Glioma	514	-0.071	0.11	NS
LIHC	Liver hepatocellular carcinoma	366	0.026	0.619	NS
OV	Ovarian serous cystadenocarcinoma	296	0.049	0.4	NS
PAAD	Pancreatic adenocarcinoma	176	0.254	0.000667	Higher
STAD	Stomach adenocarcinoma	406	-0.149	0.0027	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.326	1.14e-14	Higher

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for PRMT5.

Summary
Symbol	PRMT5
Name	protein arginine methyltransferase 5
Aliases	SKB1Hs; HRMT1L5; SKB1; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); IBP72; JBP1; 72 kDa ICln-binding pr ......
Location	14q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28591716	Pancreatic Ductal Adenocarcinoma; Colorectal Carcinoma	upstream	PR5-LL-CM01	Negative regulation	An in silico structure prediction suggested that PR5-LL-CM01 inhibits PRMT5 by binding with its active pocket.
28107179	Oropharyngeal Squamous Cell Carcinoma	upstream	IL-6	Regulation	Our mechanistic results suggest that IL-6 promotes nuclear translocation of PRMT5.
28107179	Oropharyngeal Squamous Cell Carcinoma	partner	p16	Negative correlation	Nuclear PRMT5 expression was inversely correlated with p16-status (p < 0.001) and was significantly higher in tumor samples from patients who smoked > 10 pack-years (p = 0.013). Our mechanistic results suggest that IL-6 promotes nuclear translocation of PRMT5.
28101581	Hepatocellular Carcinoma	partner	CDK4	Binding	Mechanistically, glucose promotes the interaction between PRMT5 and CDK4, which leads to activation of CDK4-RB-E2F-mediated transcription via releasing CDKN2A from CDK4.
27546619	Prostate Carcinoma	partner	Sp1; Brg1	Binding	Mechanistically, PRMT5 is recruited to the AR promoter by its interaction with Sp1, the major transcription factor responsible for AR transcription, and forms a complex with Brg1, an ATP-dependent chromatin remodeler, on the proximal promoter region of the AR gene.
27546619	Prostate Carcinoma	downstream	AR	Positive regulation	Knockdown of PRMT5 or inhibition of PRMT5 by a specific inhibitor reduces the expression of AR and suppresses the growth of multiple AR-positive, but not AR-negative, prostate cancer cells.