CR2Cancer

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF16207 RAWUL domain RING finger- and WD40-associated ubiquitin-like

Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone ubiquitination	H2AK119	H2AK119ub	16943429

> Gene Ontology [ TOP ]
Biological Process	GO:0001702 gastrulation with mouth forming second GO:0003002 regionalization GO:0006513 protein monoubiquitination GO:0007281 germ cell development GO:0007369 gastrulation GO:0007389 pattern specification process GO:0009798 axis specification GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0010390 histone monoubiquitination GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0022412 cellular process involved in reproduction in multicellular organism GO:0033522 histone H2A ubiquitination GO:0035518 histone H2A monoubiquitination GO:0036353 histone H2A-K119 monoubiquitination GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
Molecular Function	GO:0003682 chromatin binding GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:0071535 RING-like zinc finger domain binding
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0000803 sex chromosome GO:0001739 sex chromatin GO:0005720 nuclear heterochromatin GO:0016604 nuclear body GO:0031519 PcG protein complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035102 PRC1 complex GO:0044454 nuclear chromosome part GO:0044665 MLL1/2 complex GO:0071339 MLL1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1223954	c.128G>A	p.R43Q	Substitution - Missense	Large_intestine
COSM1223954	c.128G>A	p.R43Q	Substitution - Missense	Breast
COSM3803165	c.473G>A	p.R158Q	Substitution - Missense	Breast
COSM5692332	c.302G>T	p.R101M	Substitution - Missense	Soft_tissue
COSM1689409	c.344C>T	p.P115L	Substitution - Missense	Skin
COSM3725538	c.591C>T	p.T197T	Substitution - coding silent	Lung
COSM95197	c.320A>G	p.D107G	Substitution - Missense	Breast
COSM900900	c.82C>T	p.P28S	Substitution - Missense	Endometrium
COSM1663940	c.305C>T	p.P102L	Substitution - Missense	Kidney
COSM4722077	c.988G>A	p.A330T	Substitution - Missense	Large_intestine
COSM167143	c.77G>A	p.R26Q	Substitution - Missense	Large_intestine
COSM167143	c.77G>A	p.R26Q	Substitution - Missense	Stomach
COSM224181	c.100G>A	p.D34N	Substitution - Missense	Skin
COSM3400093	c.821G>A	p.S274N	Substitution - Missense	Central_nervous_system
COSM2098085	c.671G>T	p.S224I	Substitution - Missense	Lung
COSM4722075	c.381A>G	p.V127V	Substitution - coding silent	Large_intestine
COSM424789	c.133C>T	p.L45L	Substitution - coding silent	Breast
COSM4411650	c.872A>T	p.Y291F	Substitution - Missense	Oesophagus
COSM900901	c.248G>A	p.G83D	Substitution - Missense	Endometrium
COSM3385528	c.350G>A	p.R117H	Substitution - Missense	Pancreas
COSM5623749	c.103G>T	p.G35C	Substitution - Missense	Oesophagus
COSM164060	c.375G>C	p.E125D	Substitution - Missense	Breast
COSM5052871	c.240T>C	p.L80L	Substitution - coding silent	Stomach
COSM3480144	c.34C>T	p.P12S	Substitution - Missense	Skin
COSM1240077	c.900C>T	p.G300G	Substitution - coding silent	Large_intestine
COSM4722076	c.472C>T	p.R158*	Substitution - Nonsense	Large_intestine
COSM3984546	c.189T>C	p.T63T	Substitution - coding silent	Kidney
COSM3480145	c.343C>T	p.P115S	Substitution - Missense	Skin
COSM4768496	c.746A>C	p.K249T	Substitution - Missense	Biliary_tract
COSM167143	c.77G>A	p.R26Q	Substitution - Missense	Large_intestine
COSM1663939	c.272G>A	p.R91Q	Substitution - Missense	Kidney
COSM3480146	c.358T>C	p.Y120H	Substitution - Missense	Skin
COSM3803164	c.293G>T	p.R98I	Substitution - Missense	Breast
COSM3369465	c.174G>C	p.L58F	Substitution - Missense	Thyroid
COSM3943203	c.1A>G	p.M1V	Substitution - Missense	Ovary
COSM2098073	c.210delT	p.C72fs*23	Deletion - Frameshift	Large_intestine
COSM1666343	c.926T>G	p.F309C	Substitution - Missense	Eye
COSM137793	c.242G>A	p.R81K	Substitution - Missense	Skin
COSM212498	c.258A>C	p.E86D	Substitution - Missense	Breast
COSM314850	c.136C>G	p.H46D	Substitution - Missense	Soft_tissue
COSM2098079	c.355G>C	p.E119Q	Substitution - Missense	Central_nervous_system
COSM1744280	c.818G>A	p.R273Q	Substitution - Missense	Large_intestine
COSM263373	c.817C>T	p.R273*	Substitution - Nonsense	Large_intestine
COSM314850	c.136C>G	p.H46D	Substitution - Missense	Lung
COSM900899	c.11C>T	p.A4V	Substitution - Missense	Endometrium
COSM1337079	c.924delT	p.S310fs*12	Deletion - Frameshift	Large_intestine
COSM167143	c.77G>A	p.R26Q	Substitution - Missense	Large_intestine
COSM4942622	c.476G>T	p.G159V	Substitution - Missense	Liver
COSM1337078	c.587G>A	p.R196Q	Substitution - Missense	Large_intestine
COSM1668272	c.224G>T	p.C75F	Substitution - Missense	Prostate
COSM1240077	c.900C>T	p.G300G	Substitution - coding silent	Oesophagus
COSM1287660	c.183C>T	p.T61T	Substitution - coding silent	Autonomic_ganglia
COSM3789220	c.50G>A	p.W17*	Substitution - Nonsense	Urinary_tract
COSM1668273	c.760G>A	p.A254T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1744280	c.818G>A	p.R273Q	Substitution - Missense	Biliary_tract
COSM1223953	c.856G>A	p.A286T	Substitution - Missense	Large_intestine
COSM5514486	c.951A>G	p.K317K	Substitution - coding silent	Biliary_tract
COSM2098088	c.759C>T	p.N253N	Substitution - coding silent	Stomach

> Text Mining based Variations [ TOP ]
There is no record for RNF2.

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q99496	143	S	Phosphoserine	-	Yes	p.S143R (cancer: THCA)
Q99496	168	S	Phosphoserine	-	No	None detected

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.457	4.771	0.417	0.00413	NS
BRCA	Breast invasive carcinoma	112	1100	4.709	5.124	0.418	1.94e-09	NS
CESC	Cervical and endocervical cancers	3	306	4.362	4.779	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.201	4.312	0.128	0.191	NS
ESCA	Esophageal carcinoma	11	185	3.972	4.719	0.695	0.00033	Over
GBM	Glioblastoma multiforme	5	166	4.479	4.96	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.081	4.568	0.487	6.54e-10	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.57	4.704	0.066	0.246	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.212	4.162	-0.066	0.532	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.322	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.436	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.799	3.082	0.173	0.188	NS
LUAD	Lung adenocarcinoma	59	517	4.296	4.673	0.332	1.53e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	4.259	5.032	0.778	1.34e-21	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.223	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.379	4.406	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.003	4.266	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.474	4.514	-0.006	0.929	NS
READ	Rectum adenocarcinoma	10	167	4.372	4.283	-0.232	0.309	NS
SARC	Sarcoma	2	263	3.897	4.235	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.946	4.964	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.998	4.542	0.548	4.84e-07	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.021	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.287	4.396	0.073	0.0904	NS
THYM	Thymoma	2	120	3.939	4.377	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.488	4.579	0.117	0.292	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.1
Autonomic ganglia	CHP212	8.2
Autonomic ganglia	IMR32	8.4
Autonomic ganglia	KELLY	8.4
Autonomic ganglia	KPNRTBM1	8
Autonomic ganglia	KPNSI9S	8.7
Autonomic ganglia	KPNYN	7.8
Autonomic ganglia	MHHNB11	7.3
Autonomic ganglia	NB1	7.7
Autonomic ganglia	NH6	7.8
Autonomic ganglia	SHSY5Y	7.8
Autonomic ganglia	SIMA	7.9
Autonomic ganglia	SKNAS	7.6
Autonomic ganglia	SKNBE2	7.7
Autonomic ganglia	SKNDZ	7.8
Autonomic ganglia	SKNFI	7.1
Autonomic ganglia	SKNSH	7.7
Biliary tract	HUCCT1	7
Biliary tract	HUH28	6.9
Biliary tract	SNU1079	6.4
Biliary tract	SNU1196	6.2
Biliary tract	SNU245	6.8
Biliary tract	SNU308	6.7
Biliary tract	SNU478	6.2
Bone	143B	7.6
Bone	A673	7.8
Bone	CADOES1	7.6
Bone	CAL78	6.8
Bone	G292CLONEA141B1	7.9
Bone	HOS	7.3
Bone	HS706T	7.4
Bone	HS737T	6.9
Bone	HS819T	7.1
Bone	HS821T	6.6
Bone	HS822T	6.8
Bone	HS863T	6.9
Bone	HS870T	7
Bone	HS888T	7.1
Bone	MG63	7.1
Bone	MHHES1	8.3
Bone	OUMS27	6.7
Bone	RDES	7.8
Bone	SJSA1	7
Bone	SKES1	8.2
Bone	SKNMC	8
Bone	SW1353	7
Bone	T173	7
Bone	TC71	7.4
Bone	U2OS	7.1
Breast	AU565	6.1
Breast	BT20	6.2
Breast	BT474	6.4
Breast	BT483	7.3
Breast	BT549	6.6
Breast	CAL120	7
Breast	CAL148	7.7
Breast	CAL51	7.3
Breast	CAL851	7
Breast	CAMA1	7.7
Breast	DU4475	7.3
Breast	EFM192A	6.7
Breast	EFM19	7.2
Breast	EVSAT	6.4
Breast	HCC1143	6
Breast	HCC1187	7.1
Breast	HCC1395	6.5
Breast	HCC1419	6.6
Breast	HCC1428	6.8
Breast	HCC1500	7.8
Breast	HCC1569	7.3
Breast	HCC1599	7.6
Breast	HCC1806	7.4
Breast	HCC1937	5.1
Breast	HCC1954	6.9
Breast	HCC202	6.8
Breast	HCC2157	7.2
Breast	HCC2218	4.1
Breast	HCC38	7.2
Breast	HCC70	7
Breast	HDQP1	7.4
Breast	HMC18	7.8
Breast	HS274T	6.7
Breast	HS281T	6.6
Breast	HS343T	7.1
Breast	HS578T	6.5
Breast	HS606T	7.2
Breast	HS739T	6.9
Breast	HS742T	7.3
Breast	JIMT1	6.9
Breast	KPL1	7
Breast	MCF7	6.6
Breast	MDAMB134VI	5.8
Breast	MDAMB157	8.2
Breast	MDAMB175VII	7.4
Breast	MDAMB231	7.1
Breast	MDAMB361	6.5
Breast	MDAMB415	4
Breast	MDAMB436	7.5
Breast	MDAMB453	6.3
Breast	MDAMB468	6.2
Breast	SKBR3	6.5
Breast	T47D	6.7
Breast	UACC812	6.6
Breast	UACC893	4.9
Breast	YMB1	7.5
Breast	ZR751	7.6
Breast	ZR7530	6.8
Central nervous system	1321N1	7.2
Central nervous system	42MGBA	6.7
Central nervous system	8MGBA	7.5
Central nervous system	A172	7
Central nervous system	AM38	7.2
Central nervous system	BECKER	6.8
Central nervous system	CAS1	7.3
Central nervous system	CCFSTTG1	6.8
Central nervous system	D283MED	8.6
Central nervous system	D341MED	8.7
Central nervous system	DAOY	7
Central nervous system	DBTRG05MG	6.9
Central nervous system	DKMG	7.4
Central nervous system	GAMG	7.1
Central nervous system	GB1	7
Central nervous system	GI1	7.9
Central nervous system	GMS10	6.9
Central nervous system	GOS3	6.5
Central nervous system	H4	6.6
Central nervous system	HS683	7
Central nervous system	KALS1	7.3
Central nervous system	KG1C	6.8
Central nervous system	KNS42	7.5
Central nervous system	KNS60	6.7
Central nervous system	KNS81	7.2
Central nervous system	KS1	7.5
Central nervous system	LN18	6.1
Central nervous system	LN229	7.3
Central nervous system	M059K	6.6
Central nervous system	MOGGCCM	6.9
Central nervous system	MOGGUVW	7
Central nervous system	NMCG1	7
Central nervous system	ONS76	7.3
Central nervous system	SF126	6.9
Central nervous system	SF295	6.3
Central nervous system	SNB19	7.3
Central nervous system	SNU1105	6.9
Central nervous system	SNU201	6.8
Central nervous system	SNU466	7.1
Central nervous system	SNU489	6.8
Central nervous system	SNU626	6.8
Central nervous system	SNU738	7.8
Central nervous system	SW1088	6.5
Central nervous system	SW1783	6.9
Central nervous system	T98G	7.1
Central nervous system	TM31	7
Central nervous system	U118MG	6.7
Central nervous system	U138MG	6.9
Central nervous system	U251MG	7.4
Central nervous system	U87MG	6
Central nervous system	YH13	7.4
Central nervous system	YKG1	7.6
Endometrium	AN3CA	6.3
Endometrium	COLO684	7.3
Endometrium	EFE184	7.7
Endometrium	EN	7.5
Endometrium	ESS1	7.1
Endometrium	HEC108	7
Endometrium	HEC151	7.5
Endometrium	HEC1A	7.8
Endometrium	HEC1B	7.8
Endometrium	HEC251	7.3
Endometrium	HEC265	6.5
Endometrium	HEC50B	7.2
Endometrium	HEC59	7.2
Endometrium	HEC6	8.4
Endometrium	ISHIKAWAHERAKLIO02ER	7.8
Endometrium	JHUEM1	7.4
Endometrium	JHUEM2	8.3
Endometrium	JHUEM3	7.1
Endometrium	KLE	7
Endometrium	MFE280	7.2
Endometrium	MFE296	7.2
Endometrium	MFE319	6.5
Endometrium	RL952	6.6
Endometrium	SNGM	7.6
Endometrium	SNU1077	8
Endometrium	SNU685	8
Endometrium	TEN	7.5
Haematopoietic and lymphoid	697	8
Haematopoietic and lymphoid	A3KAW	7.4
Haematopoietic and lymphoid	A4FUK	6.8
Haematopoietic and lymphoid	ALLSIL	7.4
Haematopoietic and lymphoid	AML193	7.1
Haematopoietic and lymphoid	AMO1	6.8
Haematopoietic and lymphoid	BCP1	7.6
Haematopoietic and lymphoid	BDCM	7.1
Haematopoietic and lymphoid	BL41	7.1
Haematopoietic and lymphoid	BL70	7.1
Haematopoietic and lymphoid	BV173	7.1
Haematopoietic and lymphoid	CA46	7.3
Haematopoietic and lymphoid	CI1	7.2
Haematopoietic and lymphoid	CMK115	8.2
Haematopoietic and lymphoid	CMK86	8.3
Haematopoietic and lymphoid	CMK	7.9
Haematopoietic and lymphoid	CMLT1	7.4
Haematopoietic and lymphoid	COLO775	7.2
Haematopoietic and lymphoid	DAUDI	5.2
Haematopoietic and lymphoid	DB	7.6
Haematopoietic and lymphoid	DEL	7.1
Haematopoietic and lymphoid	DND41	7.4
Haematopoietic and lymphoid	DOHH2	7.2
Haematopoietic and lymphoid	EB1	7.3
Haematopoietic and lymphoid	EB2	7.2
Haematopoietic and lymphoid	EHEB	6.5
Haematopoietic and lymphoid	EJM	7.6
Haematopoietic and lymphoid	EM2	7.3
Haematopoietic and lymphoid	EOL1	7.1
Haematopoietic and lymphoid	F36P	8.2
Haematopoietic and lymphoid	GA10	8
Haematopoietic and lymphoid	GDM1	8.1
Haematopoietic and lymphoid	GRANTA519	6.4
Haematopoietic and lymphoid	HDLM2	7.4
Haematopoietic and lymphoid	HDMYZ	7.2
Haematopoietic and lymphoid	HEL9217	8.3
Haematopoietic and lymphoid	HEL	8.3
Haematopoietic and lymphoid	HH	7.7
Haematopoietic and lymphoid	HL60	8.2
Haematopoietic and lymphoid	HPBALL	7.1
Haematopoietic and lymphoid	HS604T	6.5
Haematopoietic and lymphoid	HS611T	6.9
Haematopoietic and lymphoid	HS616T	6.9
Haematopoietic and lymphoid	HS751T	7.2
Haematopoietic and lymphoid	HT	7.3
Haematopoietic and lymphoid	HTK	7.7
Haematopoietic and lymphoid	HUNS1	6.5
Haematopoietic and lymphoid	HUT102	7
Haematopoietic and lymphoid	HUT78	6.7
Haematopoietic and lymphoid	JEKO1	7.4
Haematopoietic and lymphoid	JK1	8
Haematopoietic and lymphoid	JM1	8.2
Haematopoietic and lymphoid	JURKAT	7.9
Haematopoietic and lymphoid	JURLMK1	7.7
Haematopoietic and lymphoid	JVM2	6.9
Haematopoietic and lymphoid	JVM3	7.5
Haematopoietic and lymphoid	K562	7.4
Haematopoietic and lymphoid	KARPAS299	7.3
Haematopoietic and lymphoid	KARPAS422	7.5
Haematopoietic and lymphoid	KARPAS620	7.9
Haematopoietic and lymphoid	KASUMI1	8
Haematopoietic and lymphoid	KASUMI2	7.5
Haematopoietic and lymphoid	KASUMI6	7.6
Haematopoietic and lymphoid	KCL22	7.9
Haematopoietic and lymphoid	KE37	7.7
Haematopoietic and lymphoid	KE97	6.3
Haematopoietic and lymphoid	KG1	7.7
Haematopoietic and lymphoid	KHM1B	6.9
Haematopoietic and lymphoid	KIJK	8.1
Haematopoietic and lymphoid	KMH2	8
Haematopoietic and lymphoid	KMM1	8.2
Haematopoietic and lymphoid	KMS11	8.2
Haematopoietic and lymphoid	KMS12BM	7.2
Haematopoietic and lymphoid	KMS18	6.8
Haematopoietic and lymphoid	KMS20	7.4
Haematopoietic and lymphoid	KMS21BM	7.2
Haematopoietic and lymphoid	KMS26	7.6
Haematopoietic and lymphoid	KMS27	7
Haematopoietic and lymphoid	KMS28BM	7.3
Haematopoietic and lymphoid	KMS34	7.7
Haematopoietic and lymphoid	KO52	8
Haematopoietic and lymphoid	KOPN8	7.3
Haematopoietic and lymphoid	KU812	7.7
Haematopoietic and lymphoid	KYO1	6.8
Haematopoietic and lymphoid	L1236	7.7
Haematopoietic and lymphoid	L363	7.8
Haematopoietic and lymphoid	L428	6.6
Haematopoietic and lymphoid	L540	7.6
Haematopoietic and lymphoid	LAMA84	6.8
Haematopoietic and lymphoid	LOUCY	7.7
Haematopoietic and lymphoid	LP1	8.5
Haematopoietic and lymphoid	M07E	7.7
Haematopoietic and lymphoid	MC116	7.8
Haematopoietic and lymphoid	ME1	7.5
Haematopoietic and lymphoid	MEC1	7.3
Haematopoietic and lymphoid	MEC2	6.9
Haematopoietic and lymphoid	MEG01	7.1
Haematopoietic and lymphoid	MHHCALL2	7.5
Haematopoietic and lymphoid	MHHCALL3	7.4
Haematopoietic and lymphoid	MHHCALL4	7.8
Haematopoietic and lymphoid	MINO	7
Haematopoietic and lymphoid	MJ	7.6
Haematopoietic and lymphoid	MM1S	6.7
Haematopoietic and lymphoid	MOLM13	7
Haematopoietic and lymphoid	MOLM16	8.2
Haematopoietic and lymphoid	MOLM6	7.9
Haematopoietic and lymphoid	MOLP2	7.3
Haematopoietic and lymphoid	MOLP8	7.8
Haematopoietic and lymphoid	MOLT13	7.2
Haematopoietic and lymphoid	MOLT16	8
Haematopoietic and lymphoid	MOLT4	7.3
Haematopoietic and lymphoid	MONOMAC1	7.3
Haematopoietic and lymphoid	MONOMAC6	7.2
Haematopoietic and lymphoid	MOTN1	7.5
Haematopoietic and lymphoid	MUTZ5	7.8
Haematopoietic and lymphoid	MV411	7.1
Haematopoietic and lymphoid	NALM19	7.2
Haematopoietic and lymphoid	NALM1	7.3
Haematopoietic and lymphoid	NALM6	7.4
Haematopoietic and lymphoid	NAMALWA	7.7
Haematopoietic and lymphoid	NB4	7.6
Haematopoietic and lymphoid	NCIH929	7.5
Haematopoietic and lymphoid	NCO2	8
Haematopoietic and lymphoid	NOMO1	7.3
Haematopoietic and lymphoid	NUDHL1	6.5
Haematopoietic and lymphoid	NUDUL1	7.9
Haematopoietic and lymphoid	OCIAML2	7.2
Haematopoietic and lymphoid	OCIAML3	7.5
Haematopoietic and lymphoid	OCIAML5	8
Haematopoietic and lymphoid	OCILY10	6.6
Haematopoietic and lymphoid	OCILY19	7.7
Haematopoietic and lymphoid	OCILY3	7.9
Haematopoietic and lymphoid	OCIM1	7.5
Haematopoietic and lymphoid	OPM2	7.4
Haematopoietic and lymphoid	P12ICHIKAWA	7.6
Haematopoietic and lymphoid	P31FUJ	7.7
Haematopoietic and lymphoid	P3HR1	6.5
Haematopoietic and lymphoid	PCM6	6.7
Haematopoietic and lymphoid	PEER	7.4
Haematopoietic and lymphoid	PF382	7.1
Haematopoietic and lymphoid	PFEIFFER	7.2
Haematopoietic and lymphoid	PL21	7.6
Haematopoietic and lymphoid	RAJI	6
Haematopoietic and lymphoid	RCHACV	7.8
Haematopoietic and lymphoid	REC1	8.4
Haematopoietic and lymphoid	REH	7.7
Haematopoietic and lymphoid	RI1	7.2
Haematopoietic and lymphoid	RL	6.8
Haematopoietic and lymphoid	RPMI8226	6.8
Haematopoietic and lymphoid	RPMI8402	8.2
Haematopoietic and lymphoid	RS411	7.5
Haematopoietic and lymphoid	SEM	7.4
Haematopoietic and lymphoid	SET2	7.3
Haematopoietic and lymphoid	SIGM5	7.9
Haematopoietic and lymphoid	SKM1	8.2
Haematopoietic and lymphoid	SKMM2	7.2
Haematopoietic and lymphoid	SR786	7.6
Haematopoietic and lymphoid	ST486	3.9
Haematopoietic and lymphoid	SUDHL10	6.8
Haematopoietic and lymphoid	SUDHL1	8
Haematopoietic and lymphoid	SUDHL4	6.6
Haematopoietic and lymphoid	SUDHL5	6.4
Haematopoietic and lymphoid	SUDHL6	7.3
Haematopoietic and lymphoid	SUDHL8	7.9
Haematopoietic and lymphoid	SUPB15	7.8
Haematopoietic and lymphoid	SUPHD1	7.8
Haematopoietic and lymphoid	SUPM2	7.8
Haematopoietic and lymphoid	SUPT11	7.8
Haematopoietic and lymphoid	SUPT1	7.7
Haematopoietic and lymphoid	TALL1	7.2
Haematopoietic and lymphoid	TF1	7.4
Haematopoietic and lymphoid	THP1	7.2
Haematopoietic and lymphoid	TO175T	7.1
Haematopoietic and lymphoid	TOLEDO	8.4
Haematopoietic and lymphoid	U266B1	7.6
Haematopoietic and lymphoid	U937	7.6
Haematopoietic and lymphoid	UT7	8.5
Haematopoietic and lymphoid	WSUDLCL2	6.8
Kidney	769P	7.3
Kidney	786O	7
Kidney	A498	7
Kidney	A704	7.3
Kidney	ACHN	7.5
Kidney	BFTC909	7.1
Kidney	CAKI1	7.1
Kidney	CAKI2	7.1
Kidney	CAL54	7.2
Kidney	KMRC1	7.5
Kidney	KMRC20	6.9
Kidney	KMRC2	7.3
Kidney	KMRC3	6.9
Kidney	OSRC2	6.9
Kidney	RCC10RGB	6.5
Kidney	SNU1272	7.9
Kidney	SNU349	7.3
Kidney	TUHR10TKB	7.4
Kidney	TUHR14TKB	6.3
Kidney	TUHR4TKB	7.8
Kidney	VMRCRCW	6.8
Kidney	VMRCRCZ	7.2
Large intestine	C2BBE1	7.3
Large intestine	CCK81	7.3
Large intestine	CL11	6.9
Large intestine	CL14	7.2
Large intestine	CL34	6.8
Large intestine	CL40	6.9
Large intestine	COLO205	6.9
Large intestine	COLO320	6.4
Large intestine	COLO678	7.1
Large intestine	CW2	6.7
Large intestine	DLD1	6.6
Large intestine	GP2D	7.1
Large intestine	HCC56	6.9
Large intestine	HCT116	7.8
Large intestine	HCT15	6.8
Large intestine	HS675T	7.2
Large intestine	HS698T	6.8
Large intestine	HT115	7
Large intestine	HT29	7.4
Large intestine	HT55	7.1
Large intestine	KM12	6.8
Large intestine	LOVO	7.4
Large intestine	LS1034	6.8
Large intestine	LS123	7.3
Large intestine	LS180	7.2
Large intestine	LS411N	7.1
Large intestine	LS513	8
Large intestine	MDST8	7.4
Large intestine	NCIH508	7.2
Large intestine	NCIH716	7.2
Large intestine	NCIH747	7.2
Large intestine	OUMS23	7.3
Large intestine	RCM1	7.5
Large intestine	RKO	7.5
Large intestine	SKCO1	7.6
Large intestine	SNU1040	7.1
Large intestine	SNU1197	7.4
Large intestine	SNU175	7.1
Large intestine	SNU283	6.2
Large intestine	SNU407	7.8
Large intestine	SNU503	6.5
Large intestine	SNU61	7.4
Large intestine	SNU81	7.4
Large intestine	SNUC1	7
Large intestine	SNUC2A	7.1
Large intestine	SNUC4	7.3
Large intestine	SNUC5	7.4
Large intestine	SW1116	6.6
Large intestine	SW1417	6.9
Large intestine	SW1463	6.4
Large intestine	SW403	6.2
Large intestine	SW480	7.2
Large intestine	SW48	7.5
Large intestine	SW620	6.5
Large intestine	SW837	7.7
Large intestine	SW948	7.6
Large intestine	T84	6.8
Liver	ALEXANDERCELLS	7.5
Liver	C3A	7
Liver	HEP3B217	7.3
Liver	HEPG2	7.2
Liver	HLE	7.8
Liver	HLF	7.6
Liver	HUH1	5.8
Liver	HUH6	7.6
Liver	HUH7	7.1
Liver	JHH1	7.5
Liver	JHH2	6.1
Liver	JHH4	7.9
Liver	JHH5	7.2
Liver	JHH6	7.3
Liver	JHH7	7.3
Liver	LI7	7.1
Liver	PLCPRF5	7.5
Liver	SKHEP1	8.3
Liver	SNU182	7.6
Liver	SNU387	7.7
Liver	SNU398	7.9
Liver	SNU423	7.1
Liver	SNU449	7.5
Liver	SNU475	8.1
Liver	SNU761	7
Liver	SNU878	6.8
Liver	SNU886	7.2
Lung	A549	7.4
Lung	ABC1	6.8
Lung	BEN	6.7
Lung	CAL12T	7.1
Lung	CALU1	6.9
Lung	CALU3	7.3
Lung	CALU6	7.3
Lung	CHAGOK1	7.5
Lung	COLO668	6.6
Lung	COLO699	7.6
Lung	CORL105	7.1
Lung	CORL23	7.1
Lung	CORL24	7.5
Lung	CORL279	7.7
Lung	CORL311	7.9
Lung	CORL47	7.6
Lung	CORL51	7.2
Lung	CORL88	6.9
Lung	CORL95	7.1
Lung	CPCN	6.6
Lung	DMS114	7.2
Lung	DMS153	6.9
Lung	DMS273	7.8
Lung	DMS454	7.1
Lung	DMS53	6.5
Lung	DMS79	7
Lung	DV90	7.5
Lung	EBC1	6
Lung	EPLC272H	6.6
Lung	HARA	6.8
Lung	HCC1171	6.9
Lung	HCC1195	7.1
Lung	HCC15	6
Lung	HCC2279	6.7
Lung	HCC2935	6.3
Lung	HCC33	7.1
Lung	HCC366	7.2
Lung	HCC4006	6.4
Lung	HCC44	7.3
Lung	HCC78	7.3
Lung	HCC827	7.1
Lung	HCC95	7.6
Lung	HLC1	7.2
Lung	HLFA	7
Lung	HS229T	7.2
Lung	HS618T	7.2
Lung	IALM	6.8
Lung	KNS62	7.2
Lung	LC1F	7
Lung	LC1SQSF	7.3
Lung	LCLC103H	6.6
Lung	LCLC97TM1	7.7
Lung	LK2	6.9
Lung	LOUNH91	7
Lung	LU65	7
Lung	LU99	7.6
Lung	LUDLU1	7
Lung	LXF289	7.1
Lung	MORCPR	7.4
Lung	NCIH1048	8.5
Lung	NCIH1092	7.6
Lung	NCIH1105	7.2
Lung	NCIH1155	7.7
Lung	NCIH1184	7.7
Lung	NCIH1299	6.9
Lung	NCIH1339	7.3
Lung	NCIH1341	6.9
Lung	NCIH1355	7.1
Lung	NCIH1373	7.3
Lung	NCIH1385	6.5
Lung	NCIH1395	6.4
Lung	NCIH1435	7.4
Lung	NCIH1436	7.3
Lung	NCIH1437	6.2
Lung	NCIH146	7.3
Lung	NCIH1563	7.2
Lung	NCIH1568	6.9
Lung	NCIH1573	7
Lung	NCIH1581	7.7
Lung	NCIH1618	7.4
Lung	NCIH1623	7
Lung	NCIH1648	6.7
Lung	NCIH1650	6.7
Lung	NCIH1651	7
Lung	NCIH1666	8
Lung	NCIH1693	7.3
Lung	NCIH1694	8.4
Lung	NCIH1703	7.7
Lung	NCIH1734	6.6
Lung	NCIH1755	7.5
Lung	NCIH1781	7.3
Lung	NCIH1792	7.1
Lung	NCIH1793	6.4
Lung	NCIH1836	7.1
Lung	NCIH1838	7
Lung	NCIH1869	7.2
Lung	NCIH1876	7.7
Lung	NCIH1915	7.9
Lung	NCIH1930	7.2
Lung	NCIH1944	7.4
Lung	NCIH1963	7.7
Lung	NCIH196	7
Lung	NCIH1975	6.7
Lung	NCIH2009	8.1
Lung	NCIH2023	7.4
Lung	NCIH2029	6.4
Lung	NCIH2030	6.1
Lung	NCIH2066	7.5
Lung	NCIH2081	7.7
Lung	NCIH2085	7.4
Lung	NCIH2087	7.2
Lung	NCIH209	6.6
Lung	NCIH2106	7.4
Lung	NCIH2110	7.4
Lung	NCIH211	7.1
Lung	NCIH2122	6.4
Lung	NCIH2126	6.7
Lung	NCIH2141	6.9
Lung	NCIH2170	6.5
Lung	NCIH2171	6.7
Lung	NCIH2172	8.4
Lung	NCIH2196	6.7
Lung	NCIH2227	8.4
Lung	NCIH2228	7.2
Lung	NCIH226	6.5
Lung	NCIH2286	7.4
Lung	NCIH2291	7
Lung	NCIH2342	6.9
Lung	NCIH2347	7.6
Lung	NCIH23	7.4
Lung	NCIH2405	7.9
Lung	NCIH2444	6.7
Lung	NCIH292	7.3
Lung	NCIH322	7.4
Lung	NCIH3255	7
Lung	NCIH358	7.1
Lung	NCIH441	6.7
Lung	NCIH446	7.8
Lung	NCIH460	7.2
Lung	NCIH510	6.9
Lung	NCIH520	6.2
Lung	NCIH522	8.5
Lung	NCIH524	7
Lung	NCIH526	7.9
Lung	NCIH596	7.1
Lung	NCIH647	7.3
Lung	NCIH650	7.9
Lung	NCIH661	8.5
Lung	NCIH69	7.3
Lung	NCIH727	6.8
Lung	NCIH810	7.3
Lung	NCIH82	8
Lung	NCIH838	7.1
Lung	NCIH841	8.1
Lung	NCIH854	7.2
Lung	NCIH889	7.2
Lung	PC14	7
Lung	RERFLCAD1	7
Lung	RERFLCAD2	7.1
Lung	RERFLCAI	7.7
Lung	RERFLCKJ	5.7
Lung	RERFLCMS	7.3
Lung	RERFLCSQ1	6.5
Lung	SBC5	7.7
Lung	SCLC21H	7.3
Lung	SHP77	6.6
Lung	SKLU1	6.9
Lung	SKMES1	6.8
Lung	SQ1	7.3
Lung	SW1271	6.7
Lung	SW1573	7.7
Lung	SW900	6.2
Lung	VMRCLCD	7.5
Lung	VMRCLCP	7
Oesophagus	COLO680N	6.5
Oesophagus	ECGI10	6.7
Oesophagus	KYSE140	6.8
Oesophagus	KYSE150	7
Oesophagus	KYSE180	7.2
Oesophagus	KYSE270	7.2
Oesophagus	KYSE30	7
Oesophagus	KYSE410	6.6
Oesophagus	KYSE450	7.2
Oesophagus	KYSE510	6.3
Oesophagus	KYSE520	7.4
Oesophagus	KYSE70	7.1
Oesophagus	OE19	7.4
Oesophagus	OE33	7.7
Oesophagus	TE10	6.8
Oesophagus	TE11	7.1
Oesophagus	TE14	7.3
Oesophagus	TE15	6.8
Oesophagus	TE1	7.6
Oesophagus	TE4	5.8
Oesophagus	TE5	6.9
Oesophagus	TE6	7.3
Oesophagus	TE8	6.8
Oesophagus	TE9	7
Oesophagus	TT	7.2
Ovary	59M	7.1
Ovary	A2780	8.1
Ovary	CAOV3	5.9
Ovary	CAOV4	10
Ovary	COLO704	7.4
Ovary	COV318	7.7
Ovary	COV362	7.6
Ovary	COV434	8.2
Ovary	COV504	7.4
Ovary	COV644	7.3
Ovary	EFO21	7.6
Ovary	EFO27	7.4
Ovary	ES2	7.7
Ovary	FUOV1	8
Ovary	HEYA8	7.3
Ovary	HS571T	6.6
Ovary	IGROV1	7.5
Ovary	JHOC5	8.3
Ovary	JHOM1	7
Ovary	JHOM2B	7
Ovary	JHOS2	7.5
Ovary	JHOS4	7.1
Ovary	KURAMOCHI	8
Ovary	MCAS	6.4
Ovary	NIHOVCAR3	7.5
Ovary	OAW28	7.2
Ovary	OAW42	7.7
Ovary	OC314	7.1
Ovary	OC316	7.2
Ovary	ONCODG1	7.2
Ovary	OV56	7.1
Ovary	OV7	7.4
Ovary	OV90	7.3
Ovary	OVCAR4	7.8
Ovary	OVCAR8	8.1
Ovary	OVISE	7.9
Ovary	OVK18	7.6
Ovary	OVKATE	7.1
Ovary	OVMANA	7.2
Ovary	OVSAHO	7.4
Ovary	OVTOKO	7.3
Ovary	RMGI	6.3
Ovary	RMUGS	7.1
Ovary	SKOV3	7.3
Ovary	SNU119	7.1
Ovary	SNU840	6.7
Ovary	SNU8	7.4
Ovary	TOV112D	7.6
Ovary	TOV21G	7.2
Ovary	TYKNU	7.5
Pancreas	ASPC1	7.9
Pancreas	BXPC3	7.2
Pancreas	CAPAN1	6.8
Pancreas	CAPAN2	7.8
Pancreas	CFPAC1	7.4
Pancreas	DANG	7.2
Pancreas	HPAC	7.6
Pancreas	HPAFII	7.4
Pancreas	HS766T	7
Pancreas	HUPT3	7.2
Pancreas	HUPT4	6.5
Pancreas	KCIMOH1	7.9
Pancreas	KLM1	7
Pancreas	KP2	7.1
Pancreas	KP3	7.3
Pancreas	KP4	7.6
Pancreas	L33	6.6
Pancreas	MIAPACA2	7
Pancreas	PANC0203	7.4
Pancreas	PANC0213	5.9
Pancreas	PANC0327	7.2
Pancreas	PANC0403	7.7
Pancreas	PANC0504	6.8
Pancreas	PANC0813	7
Pancreas	PANC1005	6.9
Pancreas	PANC1	7.1
Pancreas	PATU8902	7.3
Pancreas	PATU8988S	7.3
Pancreas	PATU8988T	7
Pancreas	PK1	6.7
Pancreas	PK45H	7
Pancreas	PK59	7
Pancreas	PL45	7.1
Pancreas	PSN1	7.4
Pancreas	QGP1	6.8
Pancreas	SNU213	7.2
Pancreas	SNU324	7.6
Pancreas	SNU410	7
Pancreas	SU8686	6.9
Pancreas	SUIT2	7.7
Pancreas	SW1990	7.1
Pancreas	T3M4	7.4
Pancreas	TCCPAN2	6.7
Pancreas	YAPC	7.4
Pleura	ACCMESO1	7.4
Pleura	DM3	6.9
Pleura	ISTMES1	7.5
Pleura	ISTMES2	6
Pleura	JL1	6.2
Pleura	MPP89	6.9
Pleura	MSTO211H	7.1
Pleura	NCIH2052	6.1
Pleura	NCIH2452	6.4
Pleura	NCIH28	7.4
Prostate	22RV1	7.4
Prostate	DU145	7.2
Prostate	LNCAPCLONEFGC	6.9
Prostate	MDAPCA2B	7
Prostate	NCIH660	8
Prostate	PC3	6.5
Prostate	VCAP	7.2
Salivary gland	A253	7.1
Salivary gland	YD15	7.1
Skin	A101D	7
Skin	A2058	7.5
Skin	A375	7
Skin	C32	8.4
Skin	CHL1	7
Skin	CJM	6.7
Skin	COLO679	7.6
Skin	COLO741	7.1
Skin	COLO783	7.4
Skin	COLO792	7.6
Skin	COLO800	7.2
Skin	COLO818	6.9
Skin	COLO829	7.4
Skin	COLO849	7.7
Skin	G361	7.4
Skin	GRM	7.5
Skin	HMCB	7.3
Skin	HS294T	6.7
Skin	HS600T	6.9
Skin	HS688AT	7
Skin	HS695T	6.9
Skin	HS839T	7
Skin	HS852T	7.3
Skin	HS895T	7.2
Skin	HS934T	7
Skin	HS936T	7.3
Skin	HS939T	7.7
Skin	HS940T	6.9
Skin	HS944T	6.7
Skin	HT144	7.1
Skin	IGR1	7.5
Skin	IGR37	7.1
Skin	IGR39	6.7
Skin	IPC298	6.3
Skin	K029AX	7.2
Skin	LOXIMVI	7.5
Skin	MALME3M	7.5
Skin	MDAMB435S	6.8
Skin	MELHO	7
Skin	MELJUSO	6.9
Skin	MEWO	7.4
Skin	RPMI7951	7.3
Skin	RVH421	7.2
Skin	SH4	7.4
Skin	SKMEL1	7.1
Skin	SKMEL24	6.3
Skin	SKMEL28	7.3
Skin	SKMEL2	6.8
Skin	SKMEL30	7.6
Skin	SKMEL31	7
Skin	SKMEL3	6.9
Skin	SKMEL5	7
Skin	UACC257	6.8
Skin	UACC62	6.9
Skin	WM115	6.6
Skin	WM1799	7.5
Skin	WM2664	6.5
Skin	WM793	7.4
Skin	WM88	8.1
Skin	WM983B	7.2
Small intestine	HUTU80	8
Soft tissue	A204	7.1
Soft tissue	G401	7.8
Soft tissue	G402	7.1
Soft tissue	GCT	7.2
Soft tissue	HS729	6.7
Soft tissue	HT1080	6.8
Soft tissue	KYM1	7.7
Soft tissue	MESSA	7.1
Soft tissue	RD	7.2
Soft tissue	RH30	7.3
Soft tissue	RH41	7.7
Soft tissue	RKN	6.9
Soft tissue	S117	7
Soft tissue	SJRH30	7
Soft tissue	SKLMS1	6.5
Soft tissue	SKUT1	7.5
Soft tissue	TE125T	6.7
Soft tissue	TE159T	6.8
Soft tissue	TE441T	7.4
Soft tissue	TE617T	7.1
Stomach	2313287	6.5
Stomach	AGS	7.3
Stomach	AZ521	8.2
Stomach	ECC10	7.1
Stomach	ECC12	7.1
Stomach	FU97	7.2
Stomach	GCIY	8.6
Stomach	GSS	7.7
Stomach	GSU	6.6
Stomach	HGC27	7.5
Stomach	HS746T	6.7
Stomach	HUG1N	7.4
Stomach	IM95	7.4
Stomach	KATOIII	5.7
Stomach	KE39	7.2
Stomach	LMSU	7.9
Stomach	MKN1	7.1
Stomach	MKN45	6.9
Stomach	MKN74	7.5
Stomach	MKN7	6.9
Stomach	NCCSTCK140	7.3
Stomach	NCIN87	6.9
Stomach	NUGC2	7
Stomach	NUGC3	7.2
Stomach	NUGC4	6.7
Stomach	OCUM1	7.2
Stomach	RERFGC1B	7.5
Stomach	SH10TC	7.1
Stomach	SNU16	6
Stomach	SNU1	7.6
Stomach	SNU216	6.7
Stomach	SNU520	6.1
Stomach	SNU5	6.6
Stomach	SNU601	6.7
Stomach	SNU620	6.8
Stomach	SNU668	6.6
Stomach	SNU719	7.2
Stomach	TGBC11TKB	7.6
Thyroid	8305C	7.2
Thyroid	8505C	7.1
Thyroid	BCPAP	6.9
Thyroid	BHT101	7.4
Thyroid	CAL62	7.7
Thyroid	CGTHW1	7.2
Thyroid	FTC133	7.4
Thyroid	FTC238	7.7
Thyroid	ML1	7.5
Thyroid	SW579	6.5
Thyroid	TT2609C02	7.4
Thyroid	TT	7.3
Upper aerodigestive tract	BHY	5.6
Upper aerodigestive tract	BICR16	5.7
Upper aerodigestive tract	BICR18	7
Upper aerodigestive tract	BICR22	7.1
Upper aerodigestive tract	BICR31	7.2
Upper aerodigestive tract	BICR56	7
Upper aerodigestive tract	BICR6	7
Upper aerodigestive tract	CAL27	6.4
Upper aerodigestive tract	CAL33	6.8
Upper aerodigestive tract	DETROIT562	6.9
Upper aerodigestive tract	FADU	6.5
Upper aerodigestive tract	HS840T	6.8
Upper aerodigestive tract	HSC2	7.2
Upper aerodigestive tract	HSC3	7.1
Upper aerodigestive tract	HSC4	7.5
Upper aerodigestive tract	PECAPJ15	7.4
Upper aerodigestive tract	PECAPJ34CLONEC12	7
Upper aerodigestive tract	PECAPJ41CLONED2	7.2
Upper aerodigestive tract	PECAPJ49	7.1
Upper aerodigestive tract	SCC15	7
Upper aerodigestive tract	SCC25	6.2
Upper aerodigestive tract	SCC4	7.1
Upper aerodigestive tract	SCC9	6.2
Upper aerodigestive tract	SNU1076	6.7
Upper aerodigestive tract	SNU1214	6.2
Upper aerodigestive tract	SNU46	6.6
Upper aerodigestive tract	SNU899	6.7
Upper aerodigestive tract	YD10B	7
Upper aerodigestive tract	YD38	5.9
Upper aerodigestive tract	YD8	7.1
Urinary tract	5637	6.9
Urinary tract	639V	7
Urinary tract	647V	7.6
Urinary tract	BC3C	6.4
Urinary tract	BFTC905	7.3
Urinary tract	CAL29	7.1
Urinary tract	HS172T	7
Urinary tract	HT1197	7.6
Urinary tract	HT1376	6.4
Urinary tract	J82	6.7
Urinary tract	JMSU1	7.2
Urinary tract	KMBC2	7.4
Urinary tract	KU1919	7.9
Urinary tract	RT11284	7.2
Urinary tract	RT112	6.8
Urinary tract	RT4	7
Urinary tract	SCABER	7.2
Urinary tract	SW1710	7.1
Urinary tract	SW780	7.2
Urinary tract	T24	7.1
Urinary tract	TCCSUP	7.4
Urinary tract	UMUC1	7.6
Urinary tract	UMUC3	7.6
Urinary tract	VMCUB1	6.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	10.3
Adrenal gland	10.7
Appendix	14.3
Bone marrow	8.7
Breast	14.9
Cerebral cortex	15.9
Cervix, uterine	15.6
Colon	9.5
Duodenum	8.4
Endometrium	18.2
Epididymis	9.7
Esophagus	9.8
Fallopian tube	13.8
Gallbladder	16
Heart muscle	5.7
Kidney	10.8
Liver	4.5
Lung	12.4
Lymph node	14.2
Ovary	11.7
Pancreas	1.9
Parathyroid gland	14.2
Placenta	32.1
Prostate	13.9
Rectum	11.4
Salivary gland	4.1
Seminal vesicle	14.4
Skeletal muscle	2.8
Skin	6
Small intestine	7.7
Smooth muscle	16.5
Spleen	14.6
Stomach	9.1
Testis	42
Thyroid gland	19.3
Tonsil	12.4
Urinary bladder	16.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28529595	overexpression	Gastric Carcinoma	The results demonstrate that Rnf2 is upregulated in gastric cancer cells.
28029659	overexpression	Prostate Carcinoma	Here we show that PCa tissues showed higher RNF2 expression than the benign prostatic hyperplasia (BPH) tissues.
27129178	Overexpression	Cystadenoma; Ovarian Carcinoma; Borderline Ovarian Epithelial Tumor	Our result showed that overexpression of RNF2 was observed in none of the normal ovaries, in 7% of cystadenomas, in 15% of borderline tumors, and in 41% of ovarian carcinomas, respectively (P<0.01).
26936624	Overexpression	Esophageal Carcinoma	We demonstrate that expression of RNF2 was markedly upregulated in esophageal cancer cell lines and surgically resected cancer specimens.
26869491	Overexpression (copy number gain)	Urothelial Carcinoma	Overexpression of RNF2 was observed in 44.0% of UCBs and was found to significantly associate with shortened overall and cancer-specific survival (P<0.001). Additionally, RNF2 overexpression was significantly associated with RNF2 gene amplification (P=0.004) and cell proliferation (P=0.003).
25470042	Underexpression	Breast Carcinoma	We find that in human breast cancer cell lines containing amplified 17q23, TRIM37 is upregulated and, reciprocally, the major H2A ubiquitin ligase RNF2 (also known as RING1B) is downregulated.
25431952	Overexpression	Pancreatic Carcinoma	More than 50% of the tumor cells showed a high expression of H2AK119Ub1, Ring1B, and EZH2, whereas more than 50% of the tumor cells showed a low level of H3K27Me3.
24903147	Overexpression	Pancreatic Ductal Adenocarcinoma	Here, we report that in pancreatic ductal adenocarcinoma (PDAC), elevated levels of the ubiquitin E3 ligase Ring1B and Snail, along with elevated monoubiquitination of H2A at K119 (H2AK119Ub1), are highly correlated with poor survival.
24742605	Overexpression	Ductal Breast Carcinoma; Breast Carcinoma	Here we report that the expression of the Polycomb epigenetic repressor Ring1B is enhanced in tumoral cells that invade the stroma in human ductal breast carcinoma and its expression is coincident with that of Fak in these tumors. Our findings provide new insights in the biology of the breast carcinoma and open new avenues for breast cancer prognosis and therapy.
20491773	Underexpression	Osteosarcoma	Intriguingly, polycomb repressive complex 1 members, Bmi1 and Ring1b proteins, were reduced in PHC3-expressing osteosarcoma cells.
19585519	Overexpression	Pancreatic Ductal Adenocarcinoma; Pancreatic Intraepithelial Neoplasia	In contrast, Ring1B expression was only significantly and persistently up-regulated in high-grade PanINs and in PDAC.
16528373	Overexpression	Gastrointestinal tumor; digestive System Neoplasm; pituitary adenoma; parathyroid adenoma; Lymphoma	Changes in expression associated with tumoral transformation have been found for BMI1 and RNF2, which exhibited increased expression in a large series of tumors, including gastrointestinal tumors, pituitary and parathyroid adenomas, and lymphomas, compared with their expression in normal-cell counterparts.

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.546	9.13e-33	8.4	51.5	40.1	Gain
BRCA	Breast invasive carcinoma	1075	0.366	2.01e-35	2.2	24.1	73.7	Gain
CESC	Cervical and endocervical cancers	292	0.467	3.07e-17	2.4	45.5	52.1	Gain
COAD	Colon adenocarcinoma	449	0.339	1.55e-13	9.4	69.3	21.4	Neutral
ESCA	Esophageal carcinoma	183	0.456	9.03e-11	8.7	43.7	47.5	Gain
GBM	Glioblastoma multiforme	147	0.398	5.94e-07	2.7	79.6	17.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.378	7.2e-19	7	66.7	26.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.285	2.96e-11	6.3	82.5	11.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.481	4.39e-18	6.9	86.8	6.2	Neutral
LAML	Acute Myeloid Leukemia	166	0.158	0.0423	0	98.2	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.276	2.05e-10	3.1	91	5.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.143	0.00611	1.6	26.4	72	Gain
LUAD	Lung adenocarcinoma	512	0.362	2.78e-17	2.7	27	70.3	Gain
LUSC	Lung squamous cell carcinoma	498	0.474	2.76e-29	5.2	44	50.8	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.684	9.18e-43	4.7	41.3	54	Gain
PAAD	Pancreatic adenocarcinoma	177	0.481	1.26e-11	4	64.4	31.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.412	4.95e-08	8.6	77.2	14.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.204	5.15e-06	2.4	91.6	5.9	Neutral
READ	Rectum adenocarcinoma	164	0.408	5.89e-08	8.5	61.6	29.9	Neutral
SARC	Sarcoma	255	0.441	1.45e-13	17.3	56.5	26.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.592	3.8e-36	5.4	41.1	53.4	Gain
STAD	Stomach adenocarcinoma	413	0.441	4.23e-21	4.6	63.2	32.2	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.121	0.139	1.3	52.7	46	Gain
THCA	Thyroid carcinoma	497	0.352	5.75e-16	0.6	93.8	5.6	Neutral
THYM	Thymoma	119	0.201	0.0286	0	79	21	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.459	2.4e-29	1.7	55.5	42.8	Gain

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.375	1.13e-15	17	408	-0.003	0.133	NS/NA
BRCA	Breast invasive carcinoma	-0.387	0	83	785	-0.007	0.0163	NS/NA
CESC	Cervical and endocervical cancers	-0.301	7.58e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.307	2.98e-08	19	297	0.002	0.0939	NS/NA
ESCA	Esophageal carcinoma	-0.308	1.38e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.113	0.37	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.149	0.000529	20	522	0.084	5.43e-07	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.15	0.00554	24	319	0.114	4.36e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.277	1.31e-06	23	275	0.005	1.22e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.203	0.00814	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.084	0.0528	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.319	3.74e-11	41	373	-0.003	0.208	NS/NA
LUAD	Lung adenocarcinoma	-0.151	0.000961	21	456	-0.004	0.887	NS/NA
LUSC	Lung squamous cell carcinoma	-0.31	9.2e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.228	0.00191	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.172	0.0186	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.22	3e-07	35	498	0.002	0.000471	NS/NA
READ	Rectum adenocarcinoma	-0.215	0.0309	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.262	1.76e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.448	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.318	4.38e-10	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.737	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.097	0.0212	50	509	-0.002	0.0131	NS/NA
THYM	Thymoma	-0.315	0.000432	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.182	8.33e-05	34	431	-0.007	0.0104	NS/NA

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	0	Not detected
Bone marrow	1	Low
Breast	1	Low
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	1	Low
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	2	Medium
Endometrium	0	Not detected
Epididymis	1	Low
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	1	Low
Heart muscle	2	Medium
Hippocampus	0	Not detected
Kidney	1	Low
Liver	2	Medium
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	2	Medium
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	1	Low
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	1	Low
Testis	1	Low
Thyroid gland	2	Medium
Tonsil	0	Not detected
Urinary bladder	2	Medium
Vagina	0	Not detected

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0938	NS	24476821
BRCA	Breast invasive carcinoma	521	1.24e-08	Significant	23000897
COAD	Colon adenocarcinoma	149	0.142	NS	22810696
GBM	Glioblastoma multiforme	157	0.0732	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.25e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0104	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000963	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.92e-06	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000121	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	3.44e-07	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0688	NS	26544944
READ	Rectum adenocarcinoma	67	0.521	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000205	Significant	26091043
STAD	Stomach adenocarcinoma	277	6.27e-07	Significant	25079317
THCA	Thyroid carcinoma	391	0.000719	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.169	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.273	0.239	NS
BRCA	Breast invasive carcinoma	1079	1.014	0.951	NS
CESC	Cervical and endocervical cancers	291	2.347	0.0204	Shorter
COAD	Colon adenocarcinoma	439	1.026	0.929	NS
ESCA	Esophageal carcinoma	184	1.182	0.619	NS
GBM	Glioblastoma multiforme	158	0.57	0.0234	Longer
HNSC	Head and Neck squamous cell carcinoma	518	1.222	0.306	NS
KIRC	Kidney renal clear cell carcinoma	531	0.796	0.28	NS
KIRP	Kidney renal papillary cell carcinoma	287	5.144	0.00101	Shorter
LAML	Acute Myeloid Leukemia	149	1.018	0.935	NS
LGG	Brain Lower Grade Glioma	511	0.97	0.908	NS
LIHC	Liver hepatocellular carcinoma	365	2.68	1e-04	Shorter
LUAD	Lung adenocarcinoma	502	1.417	0.0892	NS
LUSC	Lung squamous cell carcinoma	494	1.003	0.988	NS
OV	Ovarian serous cystadenocarcinoma	303	0.96	0.851	NS
PAAD	Pancreatic adenocarcinoma	177	1.395	0.256	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1541833071.447	0.0609	NS
PRAD	Prostate adenocarcinoma	497	1.555	0.63	NS
READ	Rectum adenocarcinoma	159	1.102	0.866	NS
SARC	Sarcoma	259	1.99	0.0162	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.315	0.142	NS
STAD	Stomach adenocarcinoma	388	1.26	0.295	NS
TGCT	Testicular Germ Cell Tumors	134	0.557	0.628	NS
THCA	Thyroid carcinoma	500	4.04	0.169	NS
THYM	Thymoma	119	1.141	0.871	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.788	0.0436	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.006	0.909	NS
BRCA	Breast invasive carcinoma	1071	-0.067	0.0274	Lower
CESC	Cervical and endocervical cancers	167	-0.033	0.674	NS
COAD	Colon adenocarcinoma	445	0.055	0.248	NS
ESCA	Esophageal carcinoma	162	-0.069	0.381	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.004	0.927	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.015	0.733	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.299	9.31e-07	Higher
LIHC	Liver hepatocellular carcinoma	347	0.075	0.161	NS
LUAD	Lung adenocarcinoma	507	0.058	0.195	NS
LUSC	Lung squamous cell carcinoma	497	0.036	0.421	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.019	0.74	NS
PAAD	Pancreatic adenocarcinoma	176	0.089	0.24	NS
READ	Rectum adenocarcinoma	156	0.106	0.187	NS
SKCM	Skin Cutaneous Melanoma	410	-0.053	0.289	NS
STAD	Stomach adenocarcinoma	392	-0.02	0.698	NS
TGCT	Testicular Germ Cell Tumors	81	-0.26	0.0192	Lower
THCA	Thyroid carcinoma	499	0.032	0.47	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.048	0.28	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.057	0.345	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.036	0.423	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.05	0.255	NS
LGG	Brain Lower Grade Glioma	514	0.099	0.0252	Higher
LIHC	Liver hepatocellular carcinoma	366	0.105	0.0445	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.165	0.00441	Lower
PAAD	Pancreatic adenocarcinoma	176	0.078	0.305	NS
STAD	Stomach adenocarcinoma	406	-0.145	0.00347	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.186	1.59e-05	Higher

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RNF2.

Summary
Symbol	RNF2
Name	ring finger protein 2
Aliases	DING; HIPI3; RING1B; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; huntingt ......
Location	1q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28529595	Gastric Carcinoma	downstream	p21; p27	negative regulation	The expression levels of p21 and p27 were also significantly elevated by the knockdown of Rnf2.
26936624	Esophageal Carcinoma	partner	r-H2AX; H2AK119ub	Binding	Co-immunoprecipitation (Co-IP) assay and western blot analysis were employed to detect the interaction between RNF2 and r-H2AX, H2AK119ub, and the expression of proteins associated with cell cycle and apoptosis, respectively
24903147	Pancreatic Ductal Adenocarcinoma	partner	EZH2	Binding	We found that Ring1B and the SNAG-associated chromatin modifier EZH2 formed distinct protein complexes with Snail and that EZH2 was required for Snail-Ring1A/B recruitment to the target promoter.
24903147	Pancreatic Ductal Adenocarcinoma	downstream	Snail	Positive regulation	Simultaneous depletion of Ring1A and Ring1B in pancreatic cancer cells decreased Snail binding to the target chromatin, abolished H2AK119Ub1 modification, and thereby compromised Snail-mediated transcriptional repression and cell migration
24742605	Ductal Breast Carcinoma; Breast Carcinoma	downstream	Fak; p63	Positive regulation; negative regulation	Ring1B knockdown in breast cancer cell lines revealed that Ring1B is required to sustain Fak expression in basal conditions as well as in Tgfβ-treated cells. Finally we identify p63 as a target of Ring1B to regulate Fak expression: Ring1B depletion results in enhanced p63 expression, which in turns represses Fak expression.
20491773	Osteosarcoma	partner	PHC3	Negative correlation	Intriguingly, polycomb repressive complex 1 members, Bmi1 and Ring1b proteins, were reduced in PHC3-expressing osteosarcoma cells.