CR2Cancer

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF06068 TIP49 C-terminus

Function

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.; FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.; FUNCTION: Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.; FUNCTION: May be able to bind plasminogen at cell surface and enhance plasminogen activation.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling, Histone modification write	#, Histone phosphorylation	#	#	14695187

> Gene Ontology [ TOP ]
Biological Process	GO:0000422 mitophagy GO:0000491 small nucleolar ribonucleoprotein complex assembly GO:0000492 box C/D snoRNP assembly GO:0006310 DNA recombination GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006403 RNA localization GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006914 autophagy GO:0007067 mitotic nuclear division GO:0007283 spermatogenesis GO:0010506 regulation of autophagy GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0033157 regulation of intracellular protein transport GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043486 histone exchange GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0048232 male gamete generation GO:0051222 positive regulation of protein transport GO:0061641 CENP-A containing chromatin organization GO:0061726 mitochondrion disassembly GO:0065004 protein-DNA complex assembly GO:0070585 protein localization to mitochondrion GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:0071826 ribonucleoprotein complex subunit organization GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:0090670 RNA localization to Cajal body GO:0090671 telomerase RNA localization to Cajal body GO:0090672 telomerase RNA localization GO:1903008 organelle disassembly GO:1903146 regulation of mitophagy GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904837 beta-catenin-TCF complex assembly GO:1904872 regulation of telomerase RNA localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body GO:1904951 positive regulation of establishment of protein localization
Molecular Function	GO:0003678 DNA helicase activity GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0043139 5'-3' DNA helicase activity GO:0043141 ATP-dependent 5'-3' DNA helicase activity GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0070035 purine NTP-dependent helicase activity GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000812 Swr1 complex GO:0005913 cell-cell adherens junction GO:0016363 nuclear matrix GO:0031011 Ino80 complex GO:0031248 protein acetyltransferase complex GO:0033202 DNA helicase complex GO:0034399 nuclear periphery GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0044454 nuclear chromosome part GO:0044665 MLL1/2 complex GO:0070603 SWI/SNF superfamily-type complex GO:0071339 MLL1 complex GO:0097255 R2TP complex GO:0097346 INO80-type complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04310 Wnt signaling pathway
Reactome	R-HSA-1640170: Cell Cycle R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-73886: Chromosome Maintenance R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-5688426: Deubiquitination R-HSA-180786: Extension of Telomeres R-HSA-201722: Formation of the beta-catenin R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-3214847: HATs acetylate histones R-HSA-392499: Metabolism of proteins R-HSA-774815: Nucleosome assembly R-HSA-5696398: Nucleotide Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-171319: Telomere Extension By Telomerase R-HSA-157579: Telomere Maintenance R-HSA-5689603: UCH proteinases R-HSA-5689880: Ub-specific processing proteases

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04310 Wnt signaling pathway

Reactome

R-HSA-1640170: Cell Cycle
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-73886: Chromosome Maintenance
R-HSA-5696394: DNA Damage Recognition in GG-NER
R-HSA-73894: DNA Repair
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-5688426: Deubiquitination
R-HSA-180786: Extension of Telomeres
R-HSA-201722: Formation of the beta-catenin
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-3214847: HATs acetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-774815: Nucleosome assembly
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-597592: Post-translational protein modification
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-171319: Telomere Extension By Telomerase
R-HSA-157579: Telomere Maintenance
R-HSA-5689603: UCH proteinases
R-HSA-5689880: Ub-specific processing proteases

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM253092	c.514-3delT	p.?	Unknown	Skin
COSM5978716	c.151G>A	p.V51I	Substitution - Missense	Upper_aerodigestive_tract
COSM4803888	c.194C>T	p.A65V	Substitution - Missense	Liver
COSM727605	c.1026G>T	p.E342D	Substitution - Missense	Lung
COSM253092	c.514-3delT	p.?	Unknown	Biliary_tract
COSM1536515	c.979G>A	p.V327I	Substitution - Missense	Large_intestine
COSM1037966	c.744G>A	p.A248A	Substitution - coding silent	Endometrium
COSM419852	c.241C>T	p.L81L	Substitution - coding silent	Urinary_tract
COSM125971	c.948C>A	p.H316Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4803888	c.194C>T	p.A65V	Substitution - Missense	Liver
COSM1177162	c.634G>T	p.E212*	Substitution - Nonsense	Endometrium
COSM3846137	c.826C>T	p.R276*	Substitution - Nonsense	Breast
COSM5417377	c.543G>T	p.Q181H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4113229	c.1132C>T	p.R378C	Substitution - Missense	Stomach
COSM1418748	c.743C>T	p.A248V	Substitution - Missense	Large_intestine
COSM5804249	c.231A>T	p.T77T	Substitution - coding silent	Liver
COSM5506126	c.951C>T	p.R317R	Substitution - coding silent	Biliary_tract
COSM402355	c.1099A>T	p.T367S	Substitution - Missense	Lung
COSM3059443	c.1046G>A	p.G349D	Substitution - Missense	Large_intestine
COSM4113236	c.436C>T	p.P146S	Substitution - Missense	Skin
COSM3748796	c.616T>G	p.C206G	Substitution - Missense	Stomach
COSM26516	c.306C>T	p.Y102Y	Substitution - coding silent	Skin
COSM4138412	c.263G>A	p.G88D	Substitution - Missense	Ovary
COSM172449	c.1291G>A	p.E431K	Substitution - Missense	Large_intestine
COSM203725	c.349C>T	p.R117C	Substitution - Missense	Large_intestine
COSM203725	c.349C>T	p.R117C	Substitution - Missense	Skin
COSM1308534	c.110C>T	p.S37L	Substitution - Missense	Urinary_tract
COSM4432099	c.834G>A	p.E278E	Substitution - coding silent	Oesophagus
COSM4113231	c.952G>A	p.A318T	Substitution - Missense	Stomach
COSM5440511	c.10G>C	p.E4Q	Substitution - Missense	Oesophagus
COSM1308532	c.1235C>T	p.P412L	Substitution - Missense	Urinary_tract
COSM4723168	c.1120-2delA	p.?	Unknown	Large_intestine
COSM445526	c.928G>A	p.E310K	Substitution - Missense	Breast
COSM4113230	c.1084C>T	p.R362W	Substitution - Missense	Stomach
COSM4398829	c.885C>T	p.V295V	Substitution - coding silent	Skin
COSM5506126	c.951C>T	p.R317R	Substitution - coding silent	Biliary_tract
COSM4138412	c.263G>A	p.G88D	Substitution - Missense	Liver
COSM241488	c.514-2A>T	p.?	Unknown	Prostate
COSM4835908	c.904G>A	p.D302N	Substitution - Missense	Cervix
COSM345414	c.405C>T	p.V135V	Substitution - coding silent	Lung
COSM4113235	c.687C>T	p.H229H	Substitution - coding silent	Stomach
COSM5941845	c.275C>T	p.P92L	Substitution - Missense	Skin
COSM3408202	c.1097A>G	p.Y366C	Substitution - Missense	Central_nervous_system
COSM1037967	c.697G>T	p.E233*	Substitution - Nonsense	Endometrium
COSM1177162	c.634G>T	p.E212*	Substitution - Nonsense	Breast
COSM4113236	c.436C>T	p.P146S	Substitution - Missense	Stomach
COSM4113237	c.355G>A	p.A119T	Substitution - Missense	Stomach
COSM727601	c.51C>T	p.S17S	Substitution - coding silent	Lung
COSM4803863	c.193G>T	p.A65S	Substitution - Missense	Liver
COSM5788438	c.186T>A	p.A62A	Substitution - coding silent	Breast
COSM253092	c.514-3delT	p.?	Unknown	Skin
COSM5355004	c.604-5delT	p.?	Unknown	Large_intestine
COSM5516284	c.757_758insG	p.Q254fs*27	Insertion - Frameshift	Biliary_tract
COSM3587074	c.810A>G	p.E270E	Substitution - coding silent	Skin
COSM5931381	c.773C>T	p.S258F	Substitution - Missense	Skin
COSM3059440	c.1143G>A	p.T381T	Substitution - coding silent	Large_intestine
COSM3992708	c.308C>T	p.S103L	Substitution - Missense	Kidney
COSM253092	c.514-3delT	p.?	Unknown	Ovary
COSM230532	c.1361A>T	p.Y454F	Substitution - Missense	Skin
COSM3059445	c.1010T>C	p.V337A	Substitution - Missense	Large_intestine
COSM479371	c.794A>G	p.K265R	Substitution - Missense	Kidney
COSM727603	c.532G>T	p.E178*	Substitution - Nonsense	Lung
COSM345413	c.556G>T	p.E186*	Substitution - Nonsense	Lung
COSM3059449	c.861C>T	p.I287I	Substitution - coding silent	Large_intestine
COSM26516	c.306C>T	p.Y102Y	Substitution - coding silent	Skin
COSM4113233	c.860T>C	p.I287T	Substitution - Missense	Stomach
COSM5880164	c.214C>T	p.P72S	Substitution - Missense	Skin
COSM4583907	c.883G>T	p.V295F	Substitution - Missense	Bone
COSM445525	c.1272C>T	p.S424S	Substitution - coding silent	Breast
COSM6011186	c.912C>T	p.V304V	Substitution - coding silent	Skin
COSM3059447	c.949C>T	p.R317C	Substitution - Missense	Stomach
COSM1037965	c.1107G>T	p.Q369H	Substitution - Missense	Endometrium
COSM4803863	c.193G>T	p.A65S	Substitution - Missense	Liver
COSM5749229	c.1259A>G	p.N420S	Substitution - Missense	Genital_tract
COSM3364983	c.1014C>A	p.I338I	Substitution - coding silent	Kidney
COSM4909506	c.330G>A	p.E110E	Substitution - coding silent	Liver
COSM5430096	c.1354G>A	p.D452N	Substitution - Missense	Oesophagus
COSM4113234	c.756G>A	p.G252G	Substitution - coding silent	Stomach
COSM5978716	c.151G>A	p.V51I	Substitution - Missense	Upper_aerodigestive_tract
COSM5880164	c.214C>T	p.P72S	Substitution - Missense	Skin
COSM5781154	c.744G>C	p.A248A	Substitution - coding silent	Breast
COSM4113232	c.908A>G	p.E303G	Substitution - Missense	Stomach
COSM253092	c.514-3delT	p.?	Unknown	Skin
COSM3801020	c.12G>C	p.E4D	Substitution - Missense	Urinary_tract
COSM727602	c.368G>T	p.R123L	Substitution - Missense	Lung
COSM253092	c.514-3delT	p.?	Unknown	Skin
COSM3427011	c.385G>A	p.E129K	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for RUVBL1.

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.208	6.224	1.015	3.29e-10	Over
BRCA	Breast invasive carcinoma	112	1100	4.916	5.939	1.028	1.62e-59	Over
CESC	Cervical and endocervical cancers	3	306	5.375	6.519	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.9	6.253	1.369	7.2e-55	Over
ESCA	Esophageal carcinoma	11	185	3.842	5.598	1.552	3.32e-10	Over
GBM	Glioblastoma multiforme	5	166	4.616	6.054	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.382	6.243	0.899	2.19e-20	Over
KIRC	Kidney renal clear cell carcinoma	72	534	5.352	5.05	-0.322	4.8e-09	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.438	5.898	0.504	4.92e-08	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.566	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.577	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.125	4.695	0.569	1.83e-11	NS
LUAD	Lung adenocarcinoma	59	517	5.029	5.716	0.759	9.9e-18	Over
LUSC	Lung squamous cell carcinoma	51	501	4.989	6.543	1.549	1.09e-53	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.437	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.075	5.343	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.069	4.865	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.931	5.699	0.728	1.53e-19	Over
READ	Rectum adenocarcinoma	10	167	4.905	6.308	1.313	8.7e-14	Over
SARC	Sarcoma	2	263	5.488	5.632	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.954	6.033	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.599	5.364	0.812	2.68e-13	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.815	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.963	4.999	0.027	0.548	NS
THYM	Thymoma	2	120	5.775	6.31	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.427	6.495	0.918	1.59e-15	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.8
Autonomic ganglia	CHP212	11.2
Autonomic ganglia	IMR32	10.4
Autonomic ganglia	KELLY	10.9
Autonomic ganglia	KPNRTBM1	10.9
Autonomic ganglia	KPNSI9S	10.5
Autonomic ganglia	KPNYN	10.4
Autonomic ganglia	MHHNB11	9.5
Autonomic ganglia	NB1	10.3
Autonomic ganglia	NH6	10.3
Autonomic ganglia	SHSY5Y	10.5
Autonomic ganglia	SIMA	10.9
Autonomic ganglia	SKNAS	10.8
Autonomic ganglia	SKNBE2	11.2
Autonomic ganglia	SKNDZ	10.9
Autonomic ganglia	SKNFI	10.6
Autonomic ganglia	SKNSH	10.4
Biliary tract	HUCCT1	10.8
Biliary tract	HUH28	10
Biliary tract	SNU1079	10
Biliary tract	SNU1196	11.1
Biliary tract	SNU245	9.9
Biliary tract	SNU308	10.9
Biliary tract	SNU478	10.5
Bone	143B	11.2
Bone	A673	10.7
Bone	CADOES1	10.2
Bone	CAL78	9.5
Bone	G292CLONEA141B1	10.1
Bone	HOS	10.6
Bone	HS706T	9.5
Bone	HS737T	8.8
Bone	HS819T	9
Bone	HS821T	9.1
Bone	HS822T	8.6
Bone	HS863T	9.1
Bone	HS870T	9
Bone	HS888T	9.8
Bone	MG63	10.8
Bone	MHHES1	9.7
Bone	OUMS27	9.2
Bone	RDES	10.4
Bone	SJSA1	9.6
Bone	SKES1	11.2
Bone	SKNMC	11.8
Bone	SW1353	9.2
Bone	T173	8.8
Bone	TC71	11
Bone	U2OS	9.7
Breast	AU565	9.4
Breast	BT20	10.6
Breast	BT474	9.9
Breast	BT483	9.9
Breast	BT549	10.6
Breast	CAL120	10.8
Breast	CAL148	10.8
Breast	CAL51	9.8
Breast	CAL851	9.1
Breast	CAMA1	10
Breast	DU4475	9.9
Breast	EFM192A	10.1
Breast	EFM19	10.2
Breast	EVSAT	10.9
Breast	HCC1143	10.7
Breast	HCC1187	9.3
Breast	HCC1395	10.4
Breast	HCC1419	9.1
Breast	HCC1428	9.9
Breast	HCC1500	8.9
Breast	HCC1569	10.5
Breast	HCC1599	10.4
Breast	HCC1806	9.8
Breast	HCC1937	10.3
Breast	HCC1954	9.8
Breast	HCC202	9.9
Breast	HCC2157	10.3
Breast	HCC2218	8.9
Breast	HCC38	9.9
Breast	HCC70	10.5
Breast	HDQP1	9.4
Breast	HMC18	10.2
Breast	HS274T	8.9
Breast	HS281T	9.1
Breast	HS343T	9.4
Breast	HS578T	10
Breast	HS606T	9.5
Breast	HS739T	9.1
Breast	HS742T	8.7
Breast	JIMT1	10.5
Breast	KPL1	10.3
Breast	MCF7	10
Breast	MDAMB134VI	9.4
Breast	MDAMB157	9.6
Breast	MDAMB175VII	8.9
Breast	MDAMB231	9.5
Breast	MDAMB361	10.4
Breast	MDAMB415	8.2
Breast	MDAMB436	9.8
Breast	MDAMB453	10.3
Breast	MDAMB468	9.7
Breast	SKBR3	9.4
Breast	T47D	10.1
Breast	UACC812	9.3
Breast	UACC893	10.2
Breast	YMB1	9.3
Breast	ZR751	9
Breast	ZR7530	9.3
Central nervous system	1321N1	10.6
Central nervous system	42MGBA	9.7
Central nervous system	8MGBA	10.9
Central nervous system	A172	10.1
Central nervous system	AM38	11
Central nervous system	BECKER	10
Central nervous system	CAS1	9.9
Central nervous system	CCFSTTG1	9.3
Central nervous system	D283MED	11.2
Central nervous system	D341MED	10.2
Central nervous system	DAOY	10.3
Central nervous system	DBTRG05MG	9.6
Central nervous system	DKMG	9.7
Central nervous system	GAMG	10.5
Central nervous system	GB1	10.4
Central nervous system	GI1	10
Central nervous system	GMS10	9.8
Central nervous system	GOS3	9.7
Central nervous system	H4	10.6
Central nervous system	HS683	9
Central nervous system	KALS1	9.8
Central nervous system	KG1C	9.4
Central nervous system	KNS42	9.7
Central nervous system	KNS60	9.5
Central nervous system	KNS81	9.7
Central nervous system	KS1	10.1
Central nervous system	LN18	10.1
Central nervous system	LN229	9.7
Central nervous system	M059K	9.6
Central nervous system	MOGGCCM	9.5
Central nervous system	MOGGUVW	10.1
Central nervous system	NMCG1	9.7
Central nervous system	ONS76	9.8
Central nervous system	SF126	10.1
Central nervous system	SF295	10
Central nervous system	SNB19	10
Central nervous system	SNU1105	9.6
Central nervous system	SNU201	9.5
Central nervous system	SNU466	9.5
Central nervous system	SNU489	10.1
Central nervous system	SNU626	9.2
Central nervous system	SNU738	10.5
Central nervous system	SW1088	10
Central nervous system	SW1783	9.4
Central nervous system	T98G	10
Central nervous system	TM31	10
Central nervous system	U118MG	9.9
Central nervous system	U138MG	10.2
Central nervous system	U251MG	9.8
Central nervous system	U87MG	10.1
Central nervous system	YH13	10.1
Central nervous system	YKG1	10.2
Endometrium	AN3CA	11
Endometrium	COLO684	10.8
Endometrium	EFE184	10.7
Endometrium	EN	10.7
Endometrium	ESS1	10.3
Endometrium	HEC108	8.3
Endometrium	HEC151	10.3
Endometrium	HEC1A	10.9
Endometrium	HEC1B	11.3
Endometrium	HEC251	11.3
Endometrium	HEC265	10
Endometrium	HEC50B	10.4
Endometrium	HEC59	9.7
Endometrium	HEC6	10.5
Endometrium	ISHIKAWAHERAKLIO02ER	10.2
Endometrium	JHUEM1	10.3
Endometrium	JHUEM2	10.3
Endometrium	JHUEM3	9.8
Endometrium	KLE	10.9
Endometrium	MFE280	11
Endometrium	MFE296	10.6
Endometrium	MFE319	9.8
Endometrium	RL952	9.7
Endometrium	SNGM	10.2
Endometrium	SNU1077	10.2
Endometrium	SNU685	10.3
Endometrium	TEN	10.3
Haematopoietic and lymphoid	697	10.7
Haematopoietic and lymphoid	A3KAW	10.6
Haematopoietic and lymphoid	A4FUK	10.5
Haematopoietic and lymphoid	ALLSIL	10.6
Haematopoietic and lymphoid	AML193	10.3
Haematopoietic and lymphoid	AMO1	11
Haematopoietic and lymphoid	BCP1	10.6
Haematopoietic and lymphoid	BDCM	10.1
Haematopoietic and lymphoid	BL41	10.9
Haematopoietic and lymphoid	BL70	11.1
Haematopoietic and lymphoid	BV173	9.7
Haematopoietic and lymphoid	CA46	10
Haematopoietic and lymphoid	CI1	11.1
Haematopoietic and lymphoid	CMK115	10.2
Haematopoietic and lymphoid	CMK86	10.7
Haematopoietic and lymphoid	CMK	9.8
Haematopoietic and lymphoid	CMLT1	10.3
Haematopoietic and lymphoid	COLO775	10.7
Haematopoietic and lymphoid	DAUDI	10.6
Haematopoietic and lymphoid	DB	10.7
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	11
Haematopoietic and lymphoid	DOHH2	10.6
Haematopoietic and lymphoid	EB1	10.5
Haematopoietic and lymphoid	EB2	10.9
Haematopoietic and lymphoid	EHEB	9.9
Haematopoietic and lymphoid	EJM	10.4
Haematopoietic and lymphoid	EM2	10.4
Haematopoietic and lymphoid	EOL1	10.3
Haematopoietic and lymphoid	F36P	10.2
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	9.3
Haematopoietic and lymphoid	GRANTA519	10.3
Haematopoietic and lymphoid	HDLM2	10.1
Haematopoietic and lymphoid	HDMYZ	10.3
Haematopoietic and lymphoid	HEL9217	11.2
Haematopoietic and lymphoid	HEL	10.9
Haematopoietic and lymphoid	HH	10.6
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	10.8
Haematopoietic and lymphoid	HS604T	8.8
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	9.2
Haematopoietic and lymphoid	HS751T	9.4
Haematopoietic and lymphoid	HT	11.6
Haematopoietic and lymphoid	HTK	11.5
Haematopoietic and lymphoid	HUNS1	10.9
Haematopoietic and lymphoid	HUT102	9.4
Haematopoietic and lymphoid	HUT78	11
Haematopoietic and lymphoid	JEKO1	11.5
Haematopoietic and lymphoid	JK1	10
Haematopoietic and lymphoid	JM1	10.9
Haematopoietic and lymphoid	JURKAT	9.3
Haematopoietic and lymphoid	JURLMK1	10.4
Haematopoietic and lymphoid	JVM2	10.1
Haematopoietic and lymphoid	JVM3	10
Haematopoietic and lymphoid	K562	9.8
Haematopoietic and lymphoid	KARPAS299	10.3
Haematopoietic and lymphoid	KARPAS422	11
Haematopoietic and lymphoid	KARPAS620	10.7
Haematopoietic and lymphoid	KASUMI1	10.6
Haematopoietic and lymphoid	KASUMI2	10.4
Haematopoietic and lymphoid	KASUMI6	10.2
Haematopoietic and lymphoid	KCL22	11
Haematopoietic and lymphoid	KE37	10.3
Haematopoietic and lymphoid	KE97	10.2
Haematopoietic and lymphoid	KG1	10.6
Haematopoietic and lymphoid	KHM1B	9.9
Haematopoietic and lymphoid	KIJK	10.8
Haematopoietic and lymphoid	KMH2	10.9
Haematopoietic and lymphoid	KMM1	10.8
Haematopoietic and lymphoid	KMS11	10.9
Haematopoietic and lymphoid	KMS12BM	10.8
Haematopoietic and lymphoid	KMS18	10.5
Haematopoietic and lymphoid	KMS20	10.6
Haematopoietic and lymphoid	KMS21BM	11
Haematopoietic and lymphoid	KMS26	10
Haematopoietic and lymphoid	KMS27	10.3
Haematopoietic and lymphoid	KMS28BM	10.4
Haematopoietic and lymphoid	KMS34	10.9
Haematopoietic and lymphoid	KO52	9.9
Haematopoietic and lymphoid	KOPN8	10.7
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	10.8
Haematopoietic and lymphoid	L1236	10
Haematopoietic and lymphoid	L363	9.4
Haematopoietic and lymphoid	L428	10.5
Haematopoietic and lymphoid	L540	10.1
Haematopoietic and lymphoid	LAMA84	10.4
Haematopoietic and lymphoid	LOUCY	9.6
Haematopoietic and lymphoid	LP1	10.6
Haematopoietic and lymphoid	M07E	10.7
Haematopoietic and lymphoid	MC116	10.6
Haematopoietic and lymphoid	ME1	10.8
Haematopoietic and lymphoid	MEC1	10.9
Haematopoietic and lymphoid	MEC2	10.9
Haematopoietic and lymphoid	MEG01	10.4
Haematopoietic and lymphoid	MHHCALL2	10.3
Haematopoietic and lymphoid	MHHCALL3	10.4
Haematopoietic and lymphoid	MHHCALL4	10.1
Haematopoietic and lymphoid	MINO	10.4
Haematopoietic and lymphoid	MJ	11.2
Haematopoietic and lymphoid	MM1S	10.4
Haematopoietic and lymphoid	MOLM13	10.4
Haematopoietic and lymphoid	MOLM16	10.6
Haematopoietic and lymphoid	MOLM6	10.1
Haematopoietic and lymphoid	MOLP2	10.1
Haematopoietic and lymphoid	MOLP8	9.9
Haematopoietic and lymphoid	MOLT13	10.7
Haematopoietic and lymphoid	MOLT16	10
Haematopoietic and lymphoid	MOLT4	11
Haematopoietic and lymphoid	MONOMAC1	10.1
Haematopoietic and lymphoid	MONOMAC6	10.5
Haematopoietic and lymphoid	MOTN1	9.9
Haematopoietic and lymphoid	MUTZ5	10.2
Haematopoietic and lymphoid	MV411	10.7
Haematopoietic and lymphoid	NALM19	11.2
Haematopoietic and lymphoid	NALM1	10.3
Haematopoietic and lymphoid	NALM6	10.2
Haematopoietic and lymphoid	NAMALWA	11.3
Haematopoietic and lymphoid	NB4	10.7
Haematopoietic and lymphoid	NCIH929	10
Haematopoietic and lymphoid	NCO2	10.6
Haematopoietic and lymphoid	NOMO1	10.4
Haematopoietic and lymphoid	NUDHL1	10.6
Haematopoietic and lymphoid	NUDUL1	11.2
Haematopoietic and lymphoid	OCIAML2	10.2
Haematopoietic and lymphoid	OCIAML3	10.1
Haematopoietic and lymphoid	OCIAML5	10.5
Haematopoietic and lymphoid	OCILY10	11.2
Haematopoietic and lymphoid	OCILY19	10.2
Haematopoietic and lymphoid	OCILY3	11.3
Haematopoietic and lymphoid	OCIM1	9.6
Haematopoietic and lymphoid	OPM2	9.9
Haematopoietic and lymphoid	P12ICHIKAWA	10.4
Haematopoietic and lymphoid	P31FUJ	10.1
Haematopoietic and lymphoid	P3HR1	10.6
Haematopoietic and lymphoid	PCM6	11.1
Haematopoietic and lymphoid	PEER	10.5
Haematopoietic and lymphoid	PF382	9.9
Haematopoietic and lymphoid	PFEIFFER	10.9
Haematopoietic and lymphoid	PL21	9.4
Haematopoietic and lymphoid	RAJI	11.1
Haematopoietic and lymphoid	RCHACV	11
Haematopoietic and lymphoid	REC1	11.3
Haematopoietic and lymphoid	REH	10.7
Haematopoietic and lymphoid	RI1	11.6
Haematopoietic and lymphoid	RL	11.4
Haematopoietic and lymphoid	RPMI8226	10.8
Haematopoietic and lymphoid	RPMI8402	10.8
Haematopoietic and lymphoid	RS411	10.4
Haematopoietic and lymphoid	SEM	10.5
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	11.4
Haematopoietic and lymphoid	SKM1	10.7
Haematopoietic and lymphoid	SKMM2	10.1
Haematopoietic and lymphoid	SR786	9.3
Haematopoietic and lymphoid	ST486	10.6
Haematopoietic and lymphoid	SUDHL10	11.1
Haematopoietic and lymphoid	SUDHL1	10.7
Haematopoietic and lymphoid	SUDHL4	10.8
Haematopoietic and lymphoid	SUDHL5	11.6
Haematopoietic and lymphoid	SUDHL6	10.6
Haematopoietic and lymphoid	SUDHL8	10.5
Haematopoietic and lymphoid	SUPB15	10.2
Haematopoietic and lymphoid	SUPHD1	10.1
Haematopoietic and lymphoid	SUPM2	9.7
Haematopoietic and lymphoid	SUPT11	10.6
Haematopoietic and lymphoid	SUPT1	10.6
Haematopoietic and lymphoid	TALL1	10
Haematopoietic and lymphoid	TF1	10.9
Haematopoietic and lymphoid	THP1	10.2
Haematopoietic and lymphoid	TO175T	9.1
Haematopoietic and lymphoid	TOLEDO	10.7
Haematopoietic and lymphoid	U266B1	9.6
Haematopoietic and lymphoid	U937	10
Haematopoietic and lymphoid	UT7	9.5
Haematopoietic and lymphoid	WSUDLCL2	10.6
Kidney	769P	10.4
Kidney	786O	10.2
Kidney	A498	9.4
Kidney	A704	8.6
Kidney	ACHN	10.2
Kidney	BFTC909	9.5
Kidney	CAKI1	9.8
Kidney	CAKI2	9.4
Kidney	CAL54	10.3
Kidney	KMRC1	9.4
Kidney	KMRC20	9.3
Kidney	KMRC2	10.1
Kidney	KMRC3	9
Kidney	OSRC2	10
Kidney	RCC10RGB	9
Kidney	SNU1272	9.9
Kidney	SNU349	8.8
Kidney	TUHR10TKB	10.5
Kidney	TUHR14TKB	10
Kidney	TUHR4TKB	9.9
Kidney	VMRCRCW	10
Kidney	VMRCRCZ	9.5
Large intestine	C2BBE1	10.2
Large intestine	CCK81	11
Large intestine	CL11	10.7
Large intestine	CL14	10
Large intestine	CL34	10.6
Large intestine	CL40	10
Large intestine	COLO205	10.4
Large intestine	COLO320	10.9
Large intestine	COLO678	9.8
Large intestine	CW2	10.7
Large intestine	DLD1	10.3
Large intestine	GP2D	10.8
Large intestine	HCC56	10.7
Large intestine	HCT116	11.1
Large intestine	HCT15	10.4
Large intestine	HS675T	9.3
Large intestine	HS698T	9.4
Large intestine	HT115	10.9
Large intestine	HT29	11
Large intestine	HT55	10.3
Large intestine	KM12	9.8
Large intestine	LOVO	10.3
Large intestine	LS1034	10.1
Large intestine	LS123	10.2
Large intestine	LS180	10
Large intestine	LS411N	10.5
Large intestine	LS513	10
Large intestine	MDST8	10.9
Large intestine	NCIH508	10.1
Large intestine	NCIH716	10.3
Large intestine	NCIH747	10.9
Large intestine	OUMS23	10.4
Large intestine	RCM1	10.1
Large intestine	RKO	9.7
Large intestine	SKCO1	10.1
Large intestine	SNU1040	10.6
Large intestine	SNU1197	10.4
Large intestine	SNU175	9.8
Large intestine	SNU283	9.9
Large intestine	SNU407	10.2
Large intestine	SNU503	10.8
Large intestine	SNU61	11
Large intestine	SNU81	9.6
Large intestine	SNUC1	10.5
Large intestine	SNUC2A	9.1
Large intestine	SNUC4	10.3
Large intestine	SNUC5	10.3
Large intestine	SW1116	10.4
Large intestine	SW1417	10.7
Large intestine	SW1463	10.7
Large intestine	SW403	10.6
Large intestine	SW480	10.7
Large intestine	SW48	10.5
Large intestine	SW620	10.6
Large intestine	SW837	10.8
Large intestine	SW948	10.5
Large intestine	T84	9.9
Liver	ALEXANDERCELLS	10
Liver	C3A	9.8
Liver	HEP3B217	10.2
Liver	HEPG2	9.8
Liver	HLE	10.1
Liver	HLF	9.8
Liver	HUH1	9.9
Liver	HUH6	10.5
Liver	HUH7	10.1
Liver	JHH1	9.7
Liver	JHH2	9.4
Liver	JHH4	10.1
Liver	JHH5	9.9
Liver	JHH6	9.3
Liver	JHH7	10
Liver	LI7	9.7
Liver	PLCPRF5	9.8
Liver	SKHEP1	10.7
Liver	SNU182	10
Liver	SNU387	9.7
Liver	SNU398	11
Liver	SNU423	9.9
Liver	SNU449	9.9
Liver	SNU475	9.5
Liver	SNU761	9.3
Liver	SNU878	10.1
Liver	SNU886	10.7
Lung	A549	10.3
Lung	ABC1	10.3
Lung	BEN	9.8
Lung	CAL12T	10.6
Lung	CALU1	10.1
Lung	CALU3	11.2
Lung	CALU6	10.3
Lung	CHAGOK1	10.7
Lung	COLO668	10
Lung	COLO699	10.1
Lung	CORL105	10.6
Lung	CORL23	12
Lung	CORL24	10.5
Lung	CORL279	11
Lung	CORL311	11.1
Lung	CORL47	11.2
Lung	CORL51	10.6
Lung	CORL88	10.3
Lung	CORL95	9.7
Lung	CPCN	11
Lung	DMS114	10.7
Lung	DMS153	10.1
Lung	DMS273	12.1
Lung	DMS454	10.6
Lung	DMS53	9.4
Lung	DMS79	9.8
Lung	DV90	10.6
Lung	EBC1	11.2
Lung	EPLC272H	10.2
Lung	HARA	10.9
Lung	HCC1171	10
Lung	HCC1195	10.8
Lung	HCC15	9.2
Lung	HCC2279	10.2
Lung	HCC2935	9.4
Lung	HCC33	10.6
Lung	HCC366	10.7
Lung	HCC4006	10
Lung	HCC44	10.9
Lung	HCC78	10.4
Lung	HCC827	10.8
Lung	HCC95	10.2
Lung	HLC1	10.8
Lung	HLFA	9.5
Lung	HS229T	9.9
Lung	HS618T	9.7
Lung	IALM	9.9
Lung	KNS62	10.7
Lung	LC1F	10.5
Lung	LC1SQSF	10.5
Lung	LCLC103H	10.3
Lung	LCLC97TM1	11
Lung	LK2	11.2
Lung	LOUNH91	9.9
Lung	LU65	10.3
Lung	LU99	11.2
Lung	LUDLU1	10.3
Lung	LXF289	10.3
Lung	MORCPR	10.5
Lung	NCIH1048	10.1
Lung	NCIH1092	10.6
Lung	NCIH1105	11.4
Lung	NCIH1155	10.4
Lung	NCIH1184	10.4
Lung	NCIH1299	11.4
Lung	NCIH1339	10.7
Lung	NCIH1341	10
Lung	NCIH1355	10
Lung	NCIH1373	10.6
Lung	NCIH1385	9.3
Lung	NCIH1395	9.3
Lung	NCIH1435	11
Lung	NCIH1436	11.2
Lung	NCIH1437	10.8
Lung	NCIH146	11.4
Lung	NCIH1563	9.2
Lung	NCIH1568	10.1
Lung	NCIH1573	10.1
Lung	NCIH1581	11
Lung	NCIH1618	9.6
Lung	NCIH1623	10
Lung	NCIH1648	10.8
Lung	NCIH1650	10
Lung	NCIH1651	9.5
Lung	NCIH1666	10.2
Lung	NCIH1693	9
Lung	NCIH1694	10.2
Lung	NCIH1703	11.1
Lung	NCIH1734	10.2
Lung	NCIH1755	9.7
Lung	NCIH1781	10.1
Lung	NCIH1792	10.5
Lung	NCIH1793	10
Lung	NCIH1836	10.1
Lung	NCIH1838	10.4
Lung	NCIH1869	10
Lung	NCIH1876	10.7
Lung	NCIH1915	10.1
Lung	NCIH1930	10.7
Lung	NCIH1944	10.2
Lung	NCIH1963	10.4
Lung	NCIH196	10.2
Lung	NCIH1975	10.3
Lung	NCIH2009	10.4
Lung	NCIH2023	10.8
Lung	NCIH2029	10
Lung	NCIH2030	10.3
Lung	NCIH2066	9.7
Lung	NCIH2081	11.5
Lung	NCIH2085	9.8
Lung	NCIH2087	10.7
Lung	NCIH209	10.5
Lung	NCIH2106	10.8
Lung	NCIH2110	10.7
Lung	NCIH211	10.8
Lung	NCIH2122	10
Lung	NCIH2126	9.9
Lung	NCIH2141	9.5
Lung	NCIH2170	10.6
Lung	NCIH2171	10.9
Lung	NCIH2172	10.6
Lung	NCIH2196	10.4
Lung	NCIH2227	10.4
Lung	NCIH2228	9.6
Lung	NCIH226	10.1
Lung	NCIH2286	11
Lung	NCIH2291	10.3
Lung	NCIH2342	9.8
Lung	NCIH2347	10.3
Lung	NCIH23	11.3
Lung	NCIH2405	10.1
Lung	NCIH2444	10.5
Lung	NCIH292	10.4
Lung	NCIH322	10.3
Lung	NCIH3255	9.6
Lung	NCIH358	10.6
Lung	NCIH441	9.9
Lung	NCIH446	10.5
Lung	NCIH460	11.2
Lung	NCIH510	9.8
Lung	NCIH520	11.2
Lung	NCIH522	10
Lung	NCIH524	12.3
Lung	NCIH526	11.4
Lung	NCIH596	10.2
Lung	NCIH647	10.2
Lung	NCIH650	10.5
Lung	NCIH661	10.6
Lung	NCIH69	9.9
Lung	NCIH727	9.9
Lung	NCIH810	11.5
Lung	NCIH82	11.4
Lung	NCIH838	10.8
Lung	NCIH841	10.4
Lung	NCIH854	9.3
Lung	NCIH889	10.7
Lung	PC14	10.6
Lung	RERFLCAD1	9.2
Lung	RERFLCAD2	9.7
Lung	RERFLCAI	11.1
Lung	RERFLCKJ	9.4
Lung	RERFLCMS	10
Lung	RERFLCSQ1	10
Lung	SBC5	10.5
Lung	SCLC21H	10.4
Lung	SHP77	11.3
Lung	SKLU1	9.9
Lung	SKMES1	9.2
Lung	SQ1	11.4
Lung	SW1271	10.7
Lung	SW1573	10.3
Lung	SW900	9.8
Lung	VMRCLCD	11.2
Lung	VMRCLCP	10.1
Oesophagus	COLO680N	9.2
Oesophagus	ECGI10	9.8
Oesophagus	KYSE140	10.6
Oesophagus	KYSE150	10.5
Oesophagus	KYSE180	11.6
Oesophagus	KYSE270	11.3
Oesophagus	KYSE30	8.7
Oesophagus	KYSE410	10.6
Oesophagus	KYSE450	11.6
Oesophagus	KYSE510	11
Oesophagus	KYSE520	10.1
Oesophagus	KYSE70	10.4
Oesophagus	OE19	10.5
Oesophagus	OE33	9.8
Oesophagus	TE10	10.5
Oesophagus	TE11	10.8
Oesophagus	TE14	10.4
Oesophagus	TE15	10.5
Oesophagus	TE1	10.2
Oesophagus	TE4	10.9
Oesophagus	TE5	9.6
Oesophagus	TE6	11.1
Oesophagus	TE8	10.5
Oesophagus	TE9	10.2
Oesophagus	TT	10.1
Ovary	59M	10.5
Ovary	A2780	11.3
Ovary	CAOV3	9.7
Ovary	CAOV4	10.5
Ovary	COLO704	11
Ovary	COV318	9.9
Ovary	COV362	10
Ovary	COV434	10.4
Ovary	COV504	9.9
Ovary	COV644	10.2
Ovary	EFO21	10
Ovary	EFO27	9.6
Ovary	ES2	10.9
Ovary	FUOV1	10.9
Ovary	HEYA8	10.4
Ovary	HS571T	8.9
Ovary	IGROV1	10.3
Ovary	JHOC5	10.6
Ovary	JHOM1	9.7
Ovary	JHOM2B	9.2
Ovary	JHOS2	8.9
Ovary	JHOS4	10.6
Ovary	KURAMOCHI	10.5
Ovary	MCAS	9.9
Ovary	NIHOVCAR3	11.4
Ovary	OAW28	10
Ovary	OAW42	11.2
Ovary	OC314	10.4
Ovary	OC316	10.5
Ovary	ONCODG1	11.7
Ovary	OV56	9.1
Ovary	OV7	11
Ovary	OV90	9.5
Ovary	OVCAR4	10.3
Ovary	OVCAR8	10.3
Ovary	OVISE	10.7
Ovary	OVK18	10.4
Ovary	OVKATE	9.6
Ovary	OVMANA	8.9
Ovary	OVSAHO	10.5
Ovary	OVTOKO	9.6
Ovary	RMGI	9.8
Ovary	RMUGS	10.5
Ovary	SKOV3	9.7
Ovary	SNU119	10
Ovary	SNU840	10.3
Ovary	SNU8	10.6
Ovary	TOV112D	10.8
Ovary	TOV21G	10
Ovary	TYKNU	11.3
Pancreas	ASPC1	8.8
Pancreas	BXPC3	10.3
Pancreas	CAPAN1	10.2
Pancreas	CAPAN2	10
Pancreas	CFPAC1	9.5
Pancreas	DANG	11
Pancreas	HPAC	9.3
Pancreas	HPAFII	9.9
Pancreas	HS766T	9.7
Pancreas	HUPT3	10.2
Pancreas	HUPT4	9.8
Pancreas	KCIMOH1	9.6
Pancreas	KLM1	11.5
Pancreas	KP2	9.6
Pancreas	KP3	9.4
Pancreas	KP4	10.9
Pancreas	L33	10.7
Pancreas	MIAPACA2	11.1
Pancreas	PANC0203	10.7
Pancreas	PANC0213	8.9
Pancreas	PANC0327	10.8
Pancreas	PANC0403	9.7
Pancreas	PANC0504	9
Pancreas	PANC0813	10
Pancreas	PANC1005	10.7
Pancreas	PANC1	10.9
Pancreas	PATU8902	10.9
Pancreas	PATU8988S	10.3
Pancreas	PATU8988T	11
Pancreas	PK1	10.8
Pancreas	PK45H	10.2
Pancreas	PK59	9.2
Pancreas	PL45	10.4
Pancreas	PSN1	11.1
Pancreas	QGP1	9.6
Pancreas	SNU213	10.1
Pancreas	SNU324	10.5
Pancreas	SNU410	10.5
Pancreas	SU8686	9.8
Pancreas	SUIT2	10.5
Pancreas	SW1990	10.5
Pancreas	T3M4	10.4
Pancreas	TCCPAN2	9.6
Pancreas	YAPC	10.4
Pleura	ACCMESO1	10.3
Pleura	DM3	9.9
Pleura	ISTMES1	9.7
Pleura	ISTMES2	10.4
Pleura	JL1	10.5
Pleura	MPP89	10.3
Pleura	MSTO211H	10.7
Pleura	NCIH2052	9.6
Pleura	NCIH2452	10.1
Pleura	NCIH28	10.1
Prostate	22RV1	10.9
Prostate	DU145	10.6
Prostate	LNCAPCLONEFGC	10.7
Prostate	MDAPCA2B	9.9
Prostate	NCIH660	9.8
Prostate	PC3	9.6
Prostate	VCAP	10.5
Salivary gland	A253	10
Salivary gland	YD15	11
Skin	A101D	10
Skin	A2058	10.5
Skin	A375	10.9
Skin	C32	8.9
Skin	CHL1	9.9
Skin	CJM	10.7
Skin	COLO679	9.7
Skin	COLO741	10.7
Skin	COLO783	10
Skin	COLO792	10.5
Skin	COLO800	10.8
Skin	COLO818	10.1
Skin	COLO829	9.6
Skin	COLO849	10.3
Skin	G361	11.4
Skin	GRM	11.4
Skin	HMCB	10.4
Skin	HS294T	9.9
Skin	HS600T	9.1
Skin	HS688AT	8.9
Skin	HS695T	10.1
Skin	HS839T	9.4
Skin	HS852T	9.6
Skin	HS895T	9.2
Skin	HS934T	9.4
Skin	HS936T	9.4
Skin	HS939T	9.8
Skin	HS940T	8.9
Skin	HS944T	10.4
Skin	HT144	10.8
Skin	IGR1	10.1
Skin	IGR37	11
Skin	IGR39	10.6
Skin	IPC298	10
Skin	K029AX	10.1
Skin	LOXIMVI	10.6
Skin	MALME3M	9.2
Skin	MDAMB435S	10.7
Skin	MELHO	10.2
Skin	MELJUSO	10.6
Skin	MEWO	10.7
Skin	RPMI7951	10.6
Skin	RVH421	9.6
Skin	SH4	10.7
Skin	SKMEL1	9.1
Skin	SKMEL24	9.2
Skin	SKMEL28	10.2
Skin	SKMEL2	10.8
Skin	SKMEL30	10.1
Skin	SKMEL31	8.9
Skin	SKMEL3	9.9
Skin	SKMEL5	10.1
Skin	UACC257	9.7
Skin	UACC62	11.1
Skin	WM115	9.3
Skin	WM1799	10.5
Skin	WM2664	9.9
Skin	WM793	9.8
Skin	WM88	10.9
Skin	WM983B	10.7
Small intestine	HUTU80	10.2
Soft tissue	A204	10.8
Soft tissue	G401	10.9
Soft tissue	G402	10.9
Soft tissue	GCT	10.1
Soft tissue	HS729	9.4
Soft tissue	HT1080	11.2
Soft tissue	KYM1	10.9
Soft tissue	MESSA	10.8
Soft tissue	RD	10.4
Soft tissue	RH30	11.1
Soft tissue	RH41	10.5
Soft tissue	RKN	9.8
Soft tissue	S117	9.5
Soft tissue	SJRH30	10.5
Soft tissue	SKLMS1	9.8
Soft tissue	SKUT1	10.5
Soft tissue	TE125T	9.4
Soft tissue	TE159T	9.1
Soft tissue	TE441T	9.6
Soft tissue	TE617T	10.2
Stomach	2313287	10.4
Stomach	AGS	10
Stomach	AZ521	11.3
Stomach	ECC10	10.9
Stomach	ECC12	9.8
Stomach	FU97	8.5
Stomach	GCIY	11.1
Stomach	GSS	10.2
Stomach	GSU	11
Stomach	HGC27	10.5
Stomach	HS746T	9.4
Stomach	HUG1N	10.9
Stomach	IM95	10.1
Stomach	KATOIII	10.8
Stomach	KE39	9.8
Stomach	LMSU	10.7
Stomach	MKN1	10.1
Stomach	MKN45	10.9
Stomach	MKN74	8.5
Stomach	MKN7	10.5
Stomach	NCCSTCK140	9.3
Stomach	NCIN87	10.3
Stomach	NUGC2	10.9
Stomach	NUGC3	10.6
Stomach	NUGC4	9.6
Stomach	OCUM1	9.6
Stomach	RERFGC1B	9.1
Stomach	SH10TC	10.6
Stomach	SNU16	9.6
Stomach	SNU1	10.1
Stomach	SNU216	10.3
Stomach	SNU520	10.3
Stomach	SNU5	10.3
Stomach	SNU601	10.8
Stomach	SNU620	10
Stomach	SNU668	10.3
Stomach	SNU719	8.8
Stomach	TGBC11TKB	10.1
Thyroid	8305C	10.4
Thyroid	8505C	10.9
Thyroid	BCPAP	9.5
Thyroid	BHT101	10.9
Thyroid	CAL62	10.9
Thyroid	CGTHW1	10.5
Thyroid	FTC133	10.4
Thyroid	FTC238	10.8
Thyroid	ML1	9.1
Thyroid	SW579	10.2
Thyroid	TT2609C02	10.7
Thyroid	TT	9.9
Upper aerodigestive tract	BHY	9
Upper aerodigestive tract	BICR16	10.3
Upper aerodigestive tract	BICR18	10.2
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	10.6
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	10
Upper aerodigestive tract	CAL27	9.5
Upper aerodigestive tract	CAL33	10.6
Upper aerodigestive tract	DETROIT562	10.7
Upper aerodigestive tract	FADU	10
Upper aerodigestive tract	HS840T	9.6
Upper aerodigestive tract	HSC2	9.9
Upper aerodigestive tract	HSC3	10.7
Upper aerodigestive tract	HSC4	9.1
Upper aerodigestive tract	PECAPJ15	10.1
Upper aerodigestive tract	PECAPJ34CLONEC12	10.9
Upper aerodigestive tract	PECAPJ41CLONED2	9.9
Upper aerodigestive tract	PECAPJ49	11.2
Upper aerodigestive tract	SCC15	10.1
Upper aerodigestive tract	SCC25	10.3
Upper aerodigestive tract	SCC4	10.2
Upper aerodigestive tract	SCC9	9.2
Upper aerodigestive tract	SNU1076	9.1
Upper aerodigestive tract	SNU1214	10.2
Upper aerodigestive tract	SNU46	10.7
Upper aerodigestive tract	SNU899	9.8
Upper aerodigestive tract	YD10B	10.8
Upper aerodigestive tract	YD38	10.3
Upper aerodigestive tract	YD8	9.1
Urinary tract	5637	10.2
Urinary tract	639V	11.2
Urinary tract	647V	11.1
Urinary tract	BC3C	10.9
Urinary tract	BFTC905	10.3
Urinary tract	CAL29	10.4
Urinary tract	HS172T	8.9
Urinary tract	HT1197	9.6
Urinary tract	HT1376	10.6
Urinary tract	J82	10.9
Urinary tract	JMSU1	11.5
Urinary tract	KMBC2	9.5
Urinary tract	KU1919	10.6
Urinary tract	RT11284	11.1
Urinary tract	RT112	10.8
Urinary tract	RT4	9.6
Urinary tract	SCABER	10.6
Urinary tract	SW1710	10.4
Urinary tract	SW780	9.9
Urinary tract	T24	10.7
Urinary tract	TCCSUP	9.5
Urinary tract	UMUC1	10.5
Urinary tract	UMUC3	10.7
Urinary tract	VMCUB1	9.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	17.7
Adrenal gland	15.4
Appendix	30.3
Bone marrow	11.6
Breast	22.4
Cerebral cortex	20.6
Cervix, uterine	23.8
Colon	15.8
Duodenum	11.2
Endometrium	30.1
Epididymis	14.5
Esophagus	17.4
Fallopian tube	80.9
Gallbladder	16.7
Heart muscle	15.5
Kidney	22.8
Liver	8.5
Lung	20.3
Lymph node	33.4
Ovary	18.4
Pancreas	2.2
Parathyroid gland	55.3
Placenta	39.3
Prostate	21.7
Rectum	20.8
Salivary gland	5.3
Seminal vesicle	20.5
Skeletal muscle	4.1
Skin	15.7
Small intestine	10.8
Smooth muscle	30.9
Spleen	23.9
Stomach	10.9
Testis	50.8
Thyroid gland	26.9
Tonsil	32.8
Urinary bladder	18.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27722820	overexpression	Lung Adenocarcinoma	Our study revealed that RUVBL1 expression was higher in lung adenocarcinoma specimens than in those of adjacent non-tumor tissues and in lung cancer cell lines than in normal lung cell lines.
25751257	overexpression	Renal Cell Carcinoma	In this study, we demonstrate for the first time that pontin was up-regulated in RCC, and plays a previously unknown pro-invasive role in the metastatic progression of RCC through epithelial-to-mesenchymal transition (EMT) pathway.
24518087	overexpression	Small Cell Lung Carcinoma	Dihydropyrimidinase-related protein 2, guanine nucleotide-binding protein alpha-q, laminin receptor 1, pontin, and stathmin 1 were selected as candidate biomarkers among MAPs overexpressed in SCLC.
24396308	overexpression	Esophageal Squamous Cell Carcinoma	RUVBL1 was consistently overexpressed in all three datasets, although we found inconsistent CNIH expression possibly affected by the diverse major risk factors for ESCC across different areas.
19877184	overexpression	Hepatocellular Carcinoma	We show here that Pontin messenger RNA (mRNA) is also up-regulated in human HCC 3.9-fold as compared to nontumor liver (P = 0.0004).
17442372	overexpression	Colorectal Carcinoma	Cytoplasmic pontin staining of tumor cells was present in all cases and was stronger in 84.6% and equal in 15.4% of the cases compared with normal mucosa.
12716467	overexpression	Lymphoma	Increased expression of MPHOSPH1, RUVBL1, CHN2, PSA and CDC10 genes, and reduced expression of COL1A2, COL4A1, FBLN5, CLECSF6, MIC2, CAV1 and S100A10 genes in the advanced lymphoma group were confirmed by semi-quantitative reverse transcription-PCR.
28341484	overexpression	Breast Carcinoma	Elevated expression of RUVBL1 is found in high metastatic breast cancer cells.

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.45	1.38e-21	5.4	46	48.5	Gain
BRCA	Breast invasive carcinoma	1075	0.484	2.92e-64	11.5	66.7	21.8	Neutral
CESC	Cervical and endocervical cancers	292	0.573	6.94e-27	2.1	34.2	63.7	Gain
COAD	Colon adenocarcinoma	449	0.321	3.29e-12	7.6	78.4	14	Neutral
ESCA	Esophageal carcinoma	183	0.627	2.14e-21	11.5	37.7	50.8	Gain
GBM	Glioblastoma multiforme	147	0.526	7.52e-12	6.1	75.5	18.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.534	3.1e-39	4.5	39.9	55.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.552	3.87e-43	21	66.5	12.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.61	1.07e-30	2.8	63.9	33.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.171	0.0276	2.4	97	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.354	1.47e-16	7.4	90.8	1.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.354	3.65e-12	11.3	77.2	11.5	Neutral
LUAD	Lung adenocarcinoma	512	0.528	4.77e-38	24.2	53.5	22.3	Neutral
LUSC	Lung squamous cell carcinoma	498	0.63	2.35e-56	6.4	22.5	71.1	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.522	2.26e-22	7.7	34.7	57.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.462	9.5e-11	10.2	76.8	13	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.703	1.96e-25	56.8	43.2	0	Loss
PRAD	Prostate adenocarcinoma	491	0.453	3.4e-26	2.9	82.1	15.1	Neutral
READ	Rectum adenocarcinoma	164	0.487	3.6e-11	6.1	72.6	21.3	Neutral
SARC	Sarcoma	255	0.539	1.39e-20	18.8	65.1	16.1	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.484	6.28e-23	16.3	64.6	19.1	Neutral
STAD	Stomach adenocarcinoma	413	0.384	5.76e-16	11.6	62.5	25.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.182	0.0258	16	60	24	Neutral
THCA	Thyroid carcinoma	497	0.092	0.0413	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.061	0.512	6.7	89.1	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.37	7.88e-19	3.9	75.6	20.5	Neutral

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.158	0.00108	17	408	-0.004	0.0257	NS/NA
BRCA	Breast invasive carcinoma	-0.179	1.11e-07	83	785	-0.009	0.0024	NS/NA
CESC	Cervical and endocervical cancers	-0.361	7.97e-11	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.11	0.0516	19	297	0	0.292	NS/NA
ESCA	Esophageal carcinoma	-0.447	9.73e-11	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.435	0.000339	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.334	1.95e-15	20	522	-0.004	0.368	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.284	9.68e-08	24	319	-0.004	0.518	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.209	0.000294	23	275	0.003	0.00116	NS/NA
LAML	Acute Myeloid Leukemia	-0.118	0.124	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.108	0.0125	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.104	0.0348	41	373	0	0.662	NS/NA
LUAD	Lung adenocarcinoma	-0.139	0.00235	21	456	-0.001	0.825	NS/NA
LUSC	Lung squamous cell carcinoma	-0.376	5.18e-14	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.667	0.0589	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.219	0.00298	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.469	1.4e-11	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.179	3.33e-05	35	498	-0.003	0.248	NS/NA
READ	Rectum adenocarcinoma	-0.14	0.161	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.191	0.00184	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.277	1.08e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.115	0.0269	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.319	5.45e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.066	0.122	50	509	-0.002	0.051	NS/NA
THYM	Thymoma	-0.195	0.0314	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.243	1.17e-07	34	431	-0.005	0.392	NS/NA

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	3	High
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	1	Low
Esophagus	1	Low
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	1	Low
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	1	Low
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	2	Medium
Testis	3	High
Thyroid gland	1	Low
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	0	Not detected

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.221	NS	24476821
BRCA	Breast invasive carcinoma	521	4.46e-13	Significant	23000897
COAD	Colon adenocarcinoma	149	0.08	NS	22810696
GBM	Glioblastoma multiforme	157	0.446	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000406	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0042	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.306	NS	26824661
LUAD	Lung adenocarcinoma	230	1.62e-10	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00449	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.04e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00112	Significant	26544944
READ	Rectum adenocarcinoma	67	0.739	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.295	NS	26091043
STAD	Stomach adenocarcinoma	277	6.63e-08	Significant	25079317
THCA	Thyroid carcinoma	391	6.56e-15	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.217	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.121	0.608	NS
BRCA	Breast invasive carcinoma	1079	1.054	0.808	NS
CESC	Cervical and endocervical cancers	291	1.052	0.873	NS
COAD	Colon adenocarcinoma	439	1.116	0.686	NS
ESCA	Esophageal carcinoma	184	1.102	0.785	NS
GBM	Glioblastoma multiforme	158	0.842	0.519	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.458	0.0562	NS
KIRC	Kidney renal clear cell carcinoma	531	1.435	0.0946	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.808	0.589	NS
LAML	Acute Myeloid Leukemia	149	0.975	0.943	NS
LGG	Brain Lower Grade Glioma	511	1.116	0.659	NS
LIHC	Liver hepatocellular carcinoma	365	2.646	8.61e-05	Shorter
LUAD	Lung adenocarcinoma	502	1.435	0.0901	NS
LUSC	Lung squamous cell carcinoma	494	0.931	0.71	NS
OV	Ovarian serous cystadenocarcinoma	303	0.668	0.0612	NS
PAAD	Pancreatic adenocarcinoma	177	1.508	0.152	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.474	0.532	NS
PRAD	Prostate adenocarcinoma	497	2.736	0.364	NS
READ	Rectum adenocarcinoma	159	0.659	0.513	NS
SARC	Sarcoma	259	1.715	0.0555	NS
SKCM	Skin Cutaneous Melanoma	459	1.497	0.0242	Shorter
STAD	Stomach adenocarcinoma	388	0.716	0.136	NS
TGCT	Testicular Germ Cell Tumors	134	1.092	0.95	NS
THCA	Thyroid carcinoma	500	1.317	0.718	NS
THYM	Thymoma	119	0.416	0.3	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.749	0.0716	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.087	0.079	NS
BRCA	Breast invasive carcinoma	1071	0.036	0.242	NS
CESC	Cervical and endocervical cancers	167	-0.059	0.449	NS
COAD	Colon adenocarcinoma	445	0	0.997	NS
ESCA	Esophageal carcinoma	162	0.064	0.422	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.11	0.0197	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.09	0.039	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.058	0.349	NS
LIHC	Liver hepatocellular carcinoma	347	0.095	0.0777	NS
LUAD	Lung adenocarcinoma	507	0.133	0.00278	Higher
LUSC	Lung squamous cell carcinoma	497	0.013	0.767	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.098	0.0881	NS
PAAD	Pancreatic adenocarcinoma	176	0.013	0.867	NS
READ	Rectum adenocarcinoma	156	-0.05	0.538	NS
SKCM	Skin Cutaneous Melanoma	410	-0.027	0.587	NS
STAD	Stomach adenocarcinoma	392	-0.037	0.46	NS
TGCT	Testicular Germ Cell Tumors	81	0.072	0.52	NS
THCA	Thyroid carcinoma	499	-0.012	0.791	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.081	0.0695	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.148	0.0146	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.025	0.578	NS
KIRC	Kidney renal clear cell carcinoma	525	0.153	0.00043	Higher
LGG	Brain Lower Grade Glioma	514	0.154	0.000463	Higher
LIHC	Liver hepatocellular carcinoma	366	0.113	0.0312	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.111	0.0567	NS
PAAD	Pancreatic adenocarcinoma	176	0.173	0.0215	Higher
STAD	Stomach adenocarcinoma	406	-0.142	0.00424	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.25	4.41e-09	Higher

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RUVBL1.

Summary
Symbol	RUVBL1
Name	RuvB like AAA ATPase 1
Aliases	TIP49; NMP238; RVB1; TIP49a; Pontin52; ECP54; INO80H; pontin; INO80 complex subunit H; RuvB (E coli homolog) ......
Location	3q21.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25751257	Renal Cell Carcinoma	downstream	CDH1; VIM; CTNNB1	negative regulation; positive regulation; positive regulation	Mechanistic studies show that pontin depletion up-regulated the E-cadherin protein and down-regulated vimentin protein, and decreased nuclear β-catenin expression, suggesting the involvement of EMT in pontin induced metastatic progression.
19877184	Hepatocellular Carcinoma	downstream	RUVBL2	positive regulation	Pontin depletion led to down-regulation of Reptin as shown with western blot, and vice versa.