CR2Cancer

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF06068 TIP49 C-terminus

Function

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.; FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.; FUNCTION: Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.; FUNCTION: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	18026119

> Gene Ontology [ TOP ]
Biological Process	GO:0000491 small nucleolar ribonucleoprotein complex assembly GO:0000492 box C/D snoRNP assembly GO:0006310 DNA recombination GO:0006338 chromatin remodeling GO:0006403 RNA localization GO:0006457 protein folding GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0032091 negative regulation of protein binding GO:0032355 response to estradiol GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0034502 protein localization to chromosome GO:0034644 cellular response to UV GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0043393 regulation of protein binding GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0070199 establishment of protein localization to chromosome GO:0071103 DNA conformation change GO:0071168 protein localization to chromatin GO:0071169 establishment of protein localization to chromatin GO:0071214 cellular response to abiotic stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0071733 transcriptional activation by promoter-enhancer looping GO:0071826 ribonucleoprotein complex subunit organization GO:0071898 regulation of estrogen receptor binding GO:0071899 negative regulation of estrogen receptor binding GO:0090202 gene looping GO:0090579 dsDNA loop formation GO:0090670 RNA localization to Cajal body GO:0090671 telomerase RNA localization to Cajal body GO:0090672 telomerase RNA localization GO:1900120 regulation of receptor binding GO:1900121 negative regulation of receptor binding GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1904872 regulation of telomerase RNA localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body GO:1905269 positive regulation of chromatin organization GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation
Molecular Function	GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001158 enhancer sequence-specific DNA binding GO:0003678 DNA helicase activity GO:0003682 chromatin binding GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0031490 chromatin DNA binding GO:0035326 enhancer binding GO:0042623 ATPase activity, coupled GO:0043139 5'-3' DNA helicase activity GO:0043141 ATP-dependent 5'-3' DNA helicase activity GO:0043566 structure-specific DNA binding GO:0051082 unfolded protein binding GO:0070035 purine NTP-dependent helicase activity
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000812 Swr1 complex GO:0005719 nuclear euchromatin GO:0016363 nuclear matrix GO:0031011 Ino80 complex GO:0031248 protein acetyltransferase complex GO:0033202 DNA helicase complex GO:0034399 nuclear periphery GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0044454 nuclear chromosome part GO:0044665 MLL1/2 complex GO:0070603 SWI/SNF superfamily-type complex GO:0071339 MLL1 complex GO:0097255 R2TP complex GO:0097346 INO80-type complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1640170: Cell Cycle R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-73886: Chromosome Maintenance R-HSA-180786: Extension of Telomeres R-HSA-3214847: HATs acetylate histones R-HSA-171319: Telomere Extension By Telomerase R-HSA-157579: Telomere Maintenance

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM125972	c.1235G>A	p.G412D	Substitution - Missense	Upper_aerodigestive_tract

> Text Mining based Variations [ TOP ]
There is no record for RUVBL2.

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9Y230	437	S	Phosphoserine	-	No	None detected

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.095	6.907	0.819	1.19e-08	Over
BRCA	Breast invasive carcinoma	112	1100	5.474	6.463	0.992	1.19e-46	Over
CESC	Cervical and endocervical cancers	3	306	6.161	6.93	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.247	7.072	0.921	1.31e-16	Over
ESCA	Esophageal carcinoma	11	185	5.459	6.431	0.885	5.85e-06	Over
GBM	Glioblastoma multiforme	5	166	6.347	6.64	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.373	6.578	0.209	0.0346	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.771	6.148	0.425	1.49e-09	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.064	6.634	0.628	2.48e-10	Over
LAML	Acute Myeloid Leukemia	0	173	NA	6.002	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.22	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.606	6.031	0.463	5.25e-06	NS
LUAD	Lung adenocarcinoma	59	517	5.747	6.2	0.4	5.13e-07	NS
LUSC	Lung squamous cell carcinoma	51	501	5.763	6.679	0.922	5.57e-24	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.621	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.688	6.123	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.106	5.98	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.107	6.427	0.389	6.86e-07	NS
READ	Rectum adenocarcinoma	10	167	6.216	7.154	1.007	8.07e-05	Over
SARC	Sarcoma	2	263	6.379	6.385	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.244	6.793	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.054	6.416	0.401	0.000975	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.838	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.025	6.306	0.283	5.49e-06	NS
THYM	Thymoma	2	120	6.406	7.13	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.391	7.508	1.072	2.14e-15	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.7
Autonomic ganglia	CHP212	11.3
Autonomic ganglia	IMR32	11.3
Autonomic ganglia	KELLY	11.3
Autonomic ganglia	KPNRTBM1	11.3
Autonomic ganglia	KPNSI9S	11.7
Autonomic ganglia	KPNYN	11.2
Autonomic ganglia	MHHNB11	11.1
Autonomic ganglia	NB1	10.7
Autonomic ganglia	NH6	11.2
Autonomic ganglia	SHSY5Y	11.6
Autonomic ganglia	SIMA	12.2
Autonomic ganglia	SKNAS	12.2
Autonomic ganglia	SKNBE2	11.3
Autonomic ganglia	SKNDZ	10.7
Autonomic ganglia	SKNFI	11.9
Autonomic ganglia	SKNSH	11.7
Biliary tract	HUCCT1	11.6
Biliary tract	HUH28	11.4
Biliary tract	SNU1079	11
Biliary tract	SNU1196	12.5
Biliary tract	SNU245	12.2
Biliary tract	SNU308	11.6
Biliary tract	SNU478	12.4
Bone	143B	11.5
Bone	A673	12
Bone	CADOES1	11.4
Bone	CAL78	11.2
Bone	G292CLONEA141B1	11.3
Bone	HOS	11.4
Bone	HS706T	11.3
Bone	HS737T	10.2
Bone	HS819T	10.3
Bone	HS821T	10.3
Bone	HS822T	10.2
Bone	HS863T	10.5
Bone	HS870T	10.8
Bone	HS888T	10.9
Bone	MG63	12.1
Bone	MHHES1	11.3
Bone	OUMS27	11.2
Bone	RDES	11.1
Bone	SJSA1	11.6
Bone	SKES1	11.3
Bone	SKNMC	11.9
Bone	SW1353	10.8
Bone	T173	10.5
Bone	TC71	12
Bone	U2OS	11.6
Breast	AU565	11.7
Breast	BT20	12.1
Breast	BT474	10.7
Breast	BT483	10.7
Breast	BT549	11.9
Breast	CAL120	11.8
Breast	CAL148	11.2
Breast	CAL51	10.7
Breast	CAL851	11
Breast	CAMA1	11
Breast	DU4475	11
Breast	EFM192A	12.1
Breast	EFM19	10.9
Breast	EVSAT	11.9
Breast	HCC1143	12
Breast	HCC1187	10.8
Breast	HCC1395	10.2
Breast	HCC1419	11.2
Breast	HCC1428	11.9
Breast	HCC1500	11.2
Breast	HCC1569	11
Breast	HCC1599	10.6
Breast	HCC1806	11.7
Breast	HCC1937	11.9
Breast	HCC1954	11.6
Breast	HCC202	11.8
Breast	HCC2157	11.4
Breast	HCC2218	11.5
Breast	HCC38	11.2
Breast	HCC70	11.2
Breast	HDQP1	10.6
Breast	HMC18	11.2
Breast	HS274T	10.3
Breast	HS281T	10.7
Breast	HS343T	10.8
Breast	HS578T	11.8
Breast	HS606T	10.7
Breast	HS739T	10.6
Breast	HS742T	10
Breast	JIMT1	12
Breast	KPL1	11.2
Breast	MCF7	11.7
Breast	MDAMB134VI	11.2
Breast	MDAMB157	9.8
Breast	MDAMB175VII	10.5
Breast	MDAMB231	12
Breast	MDAMB361	11.9
Breast	MDAMB415	10.8
Breast	MDAMB436	11.3
Breast	MDAMB453	11.6
Breast	MDAMB468	11.4
Breast	SKBR3	11.6
Breast	T47D	11
Breast	UACC812	11.5
Breast	UACC893	10.8
Breast	YMB1	10.6
Breast	ZR751	10.6
Breast	ZR7530	11.3
Central nervous system	1321N1	11.6
Central nervous system	42MGBA	11.6
Central nervous system	8MGBA	11.3
Central nervous system	A172	10.4
Central nervous system	AM38	11.9
Central nervous system	BECKER	11
Central nervous system	CAS1	11
Central nervous system	CCFSTTG1	11.3
Central nervous system	D283MED	12.1
Central nervous system	D341MED	11.3
Central nervous system	DAOY	12
Central nervous system	DBTRG05MG	10.9
Central nervous system	DKMG	10.3
Central nervous system	GAMG	11.1
Central nervous system	GB1	11.9
Central nervous system	GI1	11.2
Central nervous system	GMS10	11.2
Central nervous system	GOS3	10.8
Central nervous system	H4	12.2
Central nervous system	HS683	11.1
Central nervous system	KALS1	11.3
Central nervous system	KG1C	10.8
Central nervous system	KNS42	11.2
Central nervous system	KNS60	11.1
Central nervous system	KNS81	11.1
Central nervous system	KS1	11.3
Central nervous system	LN18	11.7
Central nervous system	LN229	10.9
Central nervous system	M059K	11.8
Central nervous system	MOGGCCM	11.3
Central nervous system	MOGGUVW	11.9
Central nervous system	NMCG1	10.7
Central nervous system	ONS76	10
Central nervous system	SF126	11.5
Central nervous system	SF295	12.2
Central nervous system	SNB19	11.7
Central nervous system	SNU1105	11.5
Central nervous system	SNU201	11
Central nervous system	SNU466	11
Central nervous system	SNU489	11.4
Central nervous system	SNU626	10.6
Central nervous system	SNU738	11.3
Central nervous system	SW1088	11.4
Central nervous system	SW1783	11.7
Central nervous system	T98G	11.4
Central nervous system	TM31	10.7
Central nervous system	U118MG	11.4
Central nervous system	U138MG	11
Central nervous system	U251MG	10.9
Central nervous system	U87MG	10.9
Central nervous system	YH13	12.1
Central nervous system	YKG1	11
Endometrium	AN3CA	12.2
Endometrium	COLO684	12.2
Endometrium	EFE184	11.4
Endometrium	EN	10.9
Endometrium	ESS1	11.6
Endometrium	HEC108	11.1
Endometrium	HEC151	11.3
Endometrium	HEC1A	11.9
Endometrium	HEC1B	11.9
Endometrium	HEC251	11.3
Endometrium	HEC265	11.4
Endometrium	HEC50B	11.8
Endometrium	HEC59	11
Endometrium	HEC6	11.5
Endometrium	ISHIKAWAHERAKLIO02ER	11.3
Endometrium	JHUEM1	11.4
Endometrium	JHUEM2	11.2
Endometrium	JHUEM3	10.7
Endometrium	KLE	11.9
Endometrium	MFE280	11.5
Endometrium	MFE296	12
Endometrium	MFE319	11.6
Endometrium	RL952	11.4
Endometrium	SNGM	11.2
Endometrium	SNU1077	11.8
Endometrium	SNU685	11.4
Endometrium	TEN	11.1
Haematopoietic and lymphoid	697	11.6
Haematopoietic and lymphoid	A3KAW	11.5
Haematopoietic and lymphoid	A4FUK	11.6
Haematopoietic and lymphoid	ALLSIL	11.6
Haematopoietic and lymphoid	AML193	11.4
Haematopoietic and lymphoid	AMO1	11.7
Haematopoietic and lymphoid	BCP1	11.5
Haematopoietic and lymphoid	BDCM	11.1
Haematopoietic and lymphoid	BL41	11.5
Haematopoietic and lymphoid	BL70	11.7
Haematopoietic and lymphoid	BV173	12
Haematopoietic and lymphoid	CA46	10.8
Haematopoietic and lymphoid	CI1	12
Haematopoietic and lymphoid	CMK115	11.6
Haematopoietic and lymphoid	CMK86	11.7
Haematopoietic and lymphoid	CMK	11.5
Haematopoietic and lymphoid	CMLT1	11.1
Haematopoietic and lymphoid	COLO775	11
Haematopoietic and lymphoid	DAUDI	11.4
Haematopoietic and lymphoid	DB	12
Haematopoietic and lymphoid	DEL	11
Haematopoietic and lymphoid	DND41	12.1
Haematopoietic and lymphoid	DOHH2	11.1
Haematopoietic and lymphoid	EB1	11.6
Haematopoietic and lymphoid	EB2	11.3
Haematopoietic and lymphoid	EHEB	10.3
Haematopoietic and lymphoid	EJM	11.3
Haematopoietic and lymphoid	EM2	12.2
Haematopoietic and lymphoid	EOL1	12
Haematopoietic and lymphoid	F36P	11.5
Haematopoietic and lymphoid	GA10	11.7
Haematopoietic and lymphoid	GDM1	11.1
Haematopoietic and lymphoid	GRANTA519	12.1
Haematopoietic and lymphoid	HDLM2	10.5
Haematopoietic and lymphoid	HDMYZ	11.6
Haematopoietic and lymphoid	HEL9217	11.6
Haematopoietic and lymphoid	HEL	11.5
Haematopoietic and lymphoid	HH	11.8
Haematopoietic and lymphoid	HL60	12.3
Haematopoietic and lymphoid	HPBALL	11.8
Haematopoietic and lymphoid	HS604T	10.2
Haematopoietic and lymphoid	HS611T	11.3
Haematopoietic and lymphoid	HS616T	10.5
Haematopoietic and lymphoid	HS751T	10.2
Haematopoietic and lymphoid	HT	11.7
Haematopoietic and lymphoid	HTK	12
Haematopoietic and lymphoid	HUNS1	11.7
Haematopoietic and lymphoid	HUT102	10.7
Haematopoietic and lymphoid	HUT78	12
Haematopoietic and lymphoid	JEKO1	11.6
Haematopoietic and lymphoid	JK1	10.8
Haematopoietic and lymphoid	JM1	11.4
Haematopoietic and lymphoid	JURKAT	11.5
Haematopoietic and lymphoid	JURLMK1	12
Haematopoietic and lymphoid	JVM2	10.1
Haematopoietic and lymphoid	JVM3	10.6
Haematopoietic and lymphoid	K562	11.9
Haematopoietic and lymphoid	KARPAS299	10.5
Haematopoietic and lymphoid	KARPAS422	11.4
Haematopoietic and lymphoid	KARPAS620	11.9
Haematopoietic and lymphoid	KASUMI1	11.5
Haematopoietic and lymphoid	KASUMI2	11.4
Haematopoietic and lymphoid	KASUMI6	11.3
Haematopoietic and lymphoid	KCL22	12.1
Haematopoietic and lymphoid	KE37	11.1
Haematopoietic and lymphoid	KE97	11.3
Haematopoietic and lymphoid	KG1	11.4
Haematopoietic and lymphoid	KHM1B	10.8
Haematopoietic and lymphoid	KIJK	11.9
Haematopoietic and lymphoid	KMH2	11.9
Haematopoietic and lymphoid	KMM1	11.8
Haematopoietic and lymphoid	KMS11	11.4
Haematopoietic and lymphoid	KMS12BM	11.3
Haematopoietic and lymphoid	KMS18	11
Haematopoietic and lymphoid	KMS20	11.4
Haematopoietic and lymphoid	KMS21BM	11.9
Haematopoietic and lymphoid	KMS26	10.5
Haematopoietic and lymphoid	KMS27	11.8
Haematopoietic and lymphoid	KMS28BM	11.2
Haematopoietic and lymphoid	KMS34	11.1
Haematopoietic and lymphoid	KO52	11
Haematopoietic and lymphoid	KOPN8	12
Haematopoietic and lymphoid	KU812	12.6
Haematopoietic and lymphoid	KYO1	12.9
Haematopoietic and lymphoid	L1236	11.4
Haematopoietic and lymphoid	L363	10.3
Haematopoietic and lymphoid	L428	10.9
Haematopoietic and lymphoid	L540	11
Haematopoietic and lymphoid	LAMA84	11.5
Haematopoietic and lymphoid	LOUCY	11.3
Haematopoietic and lymphoid	LP1	10.6
Haematopoietic and lymphoid	M07E	12.3
Haematopoietic and lymphoid	MC116	11.7
Haematopoietic and lymphoid	ME1	11.8
Haematopoietic and lymphoid	MEC1	10.6
Haematopoietic and lymphoid	MEC2	11.5
Haematopoietic and lymphoid	MEG01	12.7
Haematopoietic and lymphoid	MHHCALL2	11.2
Haematopoietic and lymphoid	MHHCALL3	11.4
Haematopoietic and lymphoid	MHHCALL4	11.4
Haematopoietic and lymphoid	MINO	11.5
Haematopoietic and lymphoid	MJ	11.7
Haematopoietic and lymphoid	MM1S	11.3
Haematopoietic and lymphoid	MOLM13	12.3
Haematopoietic and lymphoid	MOLM16	11.8
Haematopoietic and lymphoid	MOLM6	12.1
Haematopoietic and lymphoid	MOLP2	11.7
Haematopoietic and lymphoid	MOLP8	10.6
Haematopoietic and lymphoid	MOLT13	11.3
Haematopoietic and lymphoid	MOLT16	10.7
Haematopoietic and lymphoid	MOLT4	11.9
Haematopoietic and lymphoid	MONOMAC1	11.3
Haematopoietic and lymphoid	MONOMAC6	11.7
Haematopoietic and lymphoid	MOTN1	10.4
Haematopoietic and lymphoid	MUTZ5	11.4
Haematopoietic and lymphoid	MV411	12.3
Haematopoietic and lymphoid	NALM19	12.2
Haematopoietic and lymphoid	NALM1	11.5
Haematopoietic and lymphoid	NALM6	11.3
Haematopoietic and lymphoid	NAMALWA	11.8
Haematopoietic and lymphoid	NB4	11.7
Haematopoietic and lymphoid	NCIH929	10.8
Haematopoietic and lymphoid	NCO2	12.2
Haematopoietic and lymphoid	NOMO1	11.4
Haematopoietic and lymphoid	NUDHL1	11.8
Haematopoietic and lymphoid	NUDUL1	11.6
Haematopoietic and lymphoid	OCIAML2	11.5
Haematopoietic and lymphoid	OCIAML3	11.6
Haematopoietic and lymphoid	OCIAML5	11.8
Haematopoietic and lymphoid	OCILY10	12.2
Haematopoietic and lymphoid	OCILY19	12
Haematopoietic and lymphoid	OCILY3	11.7
Haematopoietic and lymphoid	OCIM1	11
Haematopoietic and lymphoid	OPM2	11.3
Haematopoietic and lymphoid	P12ICHIKAWA	12.1
Haematopoietic and lymphoid	P31FUJ	11.9
Haematopoietic and lymphoid	P3HR1	11.7
Haematopoietic and lymphoid	PCM6	11.2
Haematopoietic and lymphoid	PEER	11.9
Haematopoietic and lymphoid	PF382	11.2
Haematopoietic and lymphoid	PFEIFFER	11.4
Haematopoietic and lymphoid	PL21	11
Haematopoietic and lymphoid	RAJI	11.9
Haematopoietic and lymphoid	RCHACV	11.5
Haematopoietic and lymphoid	REC1	11.9
Haematopoietic and lymphoid	REH	11.9
Haematopoietic and lymphoid	RI1	12.5
Haematopoietic and lymphoid	RL	10.9
Haematopoietic and lymphoid	RPMI8226	11
Haematopoietic and lymphoid	RPMI8402	11.4
Haematopoietic and lymphoid	RS411	11.7
Haematopoietic and lymphoid	SEM	11.4
Haematopoietic and lymphoid	SET2	12.1
Haematopoietic and lymphoid	SIGM5	11.5
Haematopoietic and lymphoid	SKM1	11.2
Haematopoietic and lymphoid	SKMM2	11.3
Haematopoietic and lymphoid	SR786	10.9
Haematopoietic and lymphoid	ST486	11.7
Haematopoietic and lymphoid	SUDHL10	11.7
Haematopoietic and lymphoid	SUDHL1	11.5
Haematopoietic and lymphoid	SUDHL4	11.9
Haematopoietic and lymphoid	SUDHL5	11.3
Haematopoietic and lymphoid	SUDHL6	11.1
Haematopoietic and lymphoid	SUDHL8	12
Haematopoietic and lymphoid	SUPB15	11.5
Haematopoietic and lymphoid	SUPHD1	11.3
Haematopoietic and lymphoid	SUPM2	11
Haematopoietic and lymphoid	SUPT11	10.8
Haematopoietic and lymphoid	SUPT1	11.2
Haematopoietic and lymphoid	TALL1	11.4
Haematopoietic and lymphoid	TF1	12.5
Haematopoietic and lymphoid	THP1	11.8
Haematopoietic and lymphoid	TO175T	10.8
Haematopoietic and lymphoid	TOLEDO	11.5
Haematopoietic and lymphoid	U266B1	11.4
Haematopoietic and lymphoid	U937	12.2
Haematopoietic and lymphoid	UT7	11.4
Haematopoietic and lymphoid	WSUDLCL2	11.1
Kidney	769P	11.7
Kidney	786O	11.8
Kidney	A498	11.4
Kidney	A704	10.4
Kidney	ACHN	11.5
Kidney	BFTC909	11.5
Kidney	CAKI1	11.1
Kidney	CAKI2	12.1
Kidney	CAL54	10.6
Kidney	KMRC1	11
Kidney	KMRC20	10.9
Kidney	KMRC2	11.8
Kidney	KMRC3	10.7
Kidney	OSRC2	11.7
Kidney	RCC10RGB	11.3
Kidney	SNU1272	11.1
Kidney	SNU349	11.6
Kidney	TUHR10TKB	11.5
Kidney	TUHR14TKB	11.6
Kidney	TUHR4TKB	11
Kidney	VMRCRCW	11.1
Kidney	VMRCRCZ	11.1
Large intestine	C2BBE1	11.5
Large intestine	CCK81	11.8
Large intestine	CL11	11.4
Large intestine	CL14	11.6
Large intestine	CL34	11.6
Large intestine	CL40	11.3
Large intestine	COLO205	11.5
Large intestine	COLO320	11.3
Large intestine	COLO678	10.2
Large intestine	CW2	11.7
Large intestine	DLD1	11.6
Large intestine	GP2D	11.8
Large intestine	HCC56	11.2
Large intestine	HCT116	12.3
Large intestine	HCT15	12.1
Large intestine	HS675T	11
Large intestine	HS698T	10.4
Large intestine	HT115	11.8
Large intestine	HT29	12
Large intestine	HT55	11.6
Large intestine	KM12	11.4
Large intestine	LOVO	11.5
Large intestine	LS1034	11.3
Large intestine	LS123	11.6
Large intestine	LS180	11.5
Large intestine	LS411N	11.2
Large intestine	LS513	10.9
Large intestine	MDST8	11.8
Large intestine	NCIH508	10.8
Large intestine	NCIH716	10.8
Large intestine	NCIH747	11.2
Large intestine	OUMS23	11.2
Large intestine	RCM1	10.3
Large intestine	RKO	11.4
Large intestine	SKCO1	11.1
Large intestine	SNU1040	11.7
Large intestine	SNU1197	11.5
Large intestine	SNU175	11.1
Large intestine	SNU283	11.2
Large intestine	SNU407	11.6
Large intestine	SNU503	11.9
Large intestine	SNU61	11.4
Large intestine	SNU81	11.2
Large intestine	SNUC1	11.7
Large intestine	SNUC2A	10.6
Large intestine	SNUC4	11.7
Large intestine	SNUC5	11.3
Large intestine	SW1116	11.1
Large intestine	SW1417	12
Large intestine	SW1463	11.1
Large intestine	SW403	10.4
Large intestine	SW480	11.9
Large intestine	SW48	11.5
Large intestine	SW620	11.7
Large intestine	SW837	11.3
Large intestine	SW948	10.8
Large intestine	T84	11.3
Liver	ALEXANDERCELLS	11
Liver	C3A	10.8
Liver	HEP3B217	10.8
Liver	HEPG2	11.2
Liver	HLE	11.6
Liver	HLF	12
Liver	HUH1	11.7
Liver	HUH6	10.5
Liver	HUH7	11.2
Liver	JHH1	11.7
Liver	JHH2	11.5
Liver	JHH4	12.6
Liver	JHH5	12.3
Liver	JHH6	10.9
Liver	JHH7	11.1
Liver	LI7	11.7
Liver	PLCPRF5	11.5
Liver	SKHEP1	11.7
Liver	SNU182	11.9
Liver	SNU387	11.2
Liver	SNU398	12.1
Liver	SNU423	11.1
Liver	SNU449	11.7
Liver	SNU475	11.3
Liver	SNU761	11.1
Liver	SNU878	11.7
Liver	SNU886	12.1
Lung	A549	11.9
Lung	ABC1	11.5
Lung	BEN	10.6
Lung	CAL12T	11.6
Lung	CALU1	11.5
Lung	CALU3	11.6
Lung	CALU6	12
Lung	CHAGOK1	11.5
Lung	COLO668	10
Lung	COLO699	11.1
Lung	CORL105	11.2
Lung	CORL23	12
Lung	CORL24	11.2
Lung	CORL279	11.5
Lung	CORL311	11.7
Lung	CORL47	11.6
Lung	CORL51	11
Lung	CORL88	11.2
Lung	CORL95	10.9
Lung	CPCN	11.3
Lung	DMS114	11
Lung	DMS153	10.7
Lung	DMS273	12.1
Lung	DMS454	10.9
Lung	DMS53	11.2
Lung	DMS79	11.1
Lung	DV90	11.7
Lung	EBC1	11.6
Lung	EPLC272H	10.9
Lung	HARA	11.5
Lung	HCC1171	11
Lung	HCC1195	10.7
Lung	HCC15	11.8
Lung	HCC2279	11.4
Lung	HCC2935	11
Lung	HCC33	10.6
Lung	HCC366	11.4
Lung	HCC4006	10.4
Lung	HCC44	12.2
Lung	HCC78	11.4
Lung	HCC827	11.6
Lung	HCC95	11.1
Lung	HLC1	10.9
Lung	HLFA	10.9
Lung	HS229T	11.2
Lung	HS618T	11
Lung	IALM	11.9
Lung	KNS62	11.5
Lung	LC1F	10.8
Lung	LC1SQSF	10.7
Lung	LCLC103H	11.6
Lung	LCLC97TM1	11
Lung	LK2	11.7
Lung	LOUNH91	11.9
Lung	LU65	11.8
Lung	LU99	12
Lung	LUDLU1	11.1
Lung	LXF289	10.8
Lung	MORCPR	11.4
Lung	NCIH1048	10.7
Lung	NCIH1092	10.7
Lung	NCIH1105	11.5
Lung	NCIH1155	11.5
Lung	NCIH1184	11.2
Lung	NCIH1299	12.2
Lung	NCIH1339	12.3
Lung	NCIH1341	11.6
Lung	NCIH1355	12.1
Lung	NCIH1373	11.4
Lung	NCIH1385	10.8
Lung	NCIH1395	11.2
Lung	NCIH1435	11.3
Lung	NCIH1436	11.6
Lung	NCIH1437	11
Lung	NCIH146	11.4
Lung	NCIH1563	11.2
Lung	NCIH1568	11.4
Lung	NCIH1573	10.4
Lung	NCIH1581	10.9
Lung	NCIH1618	11.2
Lung	NCIH1623	11.7
Lung	NCIH1648	11
Lung	NCIH1650	12.3
Lung	NCIH1651	11.1
Lung	NCIH1666	11.2
Lung	NCIH1693	11
Lung	NCIH1694	10.9
Lung	NCIH1703	11.3
Lung	NCIH1734	11.8
Lung	NCIH1755	12.1
Lung	NCIH1781	10.4
Lung	NCIH1792	12.6
Lung	NCIH1793	11.9
Lung	NCIH1836	11.1
Lung	NCIH1838	11.5
Lung	NCIH1869	11.3
Lung	NCIH1876	10.6
Lung	NCIH1915	10.6
Lung	NCIH1930	12.3
Lung	NCIH1944	11.5
Lung	NCIH1963	11
Lung	NCIH196	11
Lung	NCIH1975	11.4
Lung	NCIH2009	11.4
Lung	NCIH2023	12
Lung	NCIH2029	11.1
Lung	NCIH2030	12
Lung	NCIH2066	11.4
Lung	NCIH2081	11.1
Lung	NCIH2085	12.2
Lung	NCIH2087	11.8
Lung	NCIH209	11.4
Lung	NCIH2106	11.6
Lung	NCIH2110	10.6
Lung	NCIH211	12.3
Lung	NCIH2122	12.1
Lung	NCIH2126	12
Lung	NCIH2141	11.2
Lung	NCIH2170	12.3
Lung	NCIH2171	12
Lung	NCIH2172	11.1
Lung	NCIH2196	10.8
Lung	NCIH2227	11
Lung	NCIH2228	11.3
Lung	NCIH226	11.7
Lung	NCIH2286	11.3
Lung	NCIH2291	11.5
Lung	NCIH2342	11.5
Lung	NCIH2347	11.5
Lung	NCIH23	12.1
Lung	NCIH2405	11.5
Lung	NCIH2444	11.6
Lung	NCIH292	11.1
Lung	NCIH322	11.5
Lung	NCIH3255	11.7
Lung	NCIH358	12
Lung	NCIH441	11
Lung	NCIH446	12.5
Lung	NCIH460	11.6
Lung	NCIH510	11.1
Lung	NCIH520	11.5
Lung	NCIH522	10.8
Lung	NCIH524	11.8
Lung	NCIH526	11.7
Lung	NCIH596	11.1
Lung	NCIH647	11.5
Lung	NCIH650	11.7
Lung	NCIH661	10.8
Lung	NCIH69	11.4
Lung	NCIH727	11
Lung	NCIH810	11.7
Lung	NCIH82	12.1
Lung	NCIH838	11.7
Lung	NCIH841	11.6
Lung	NCIH854	11.2
Lung	NCIH889	11.5
Lung	PC14	11.7
Lung	RERFLCAD1	10.8
Lung	RERFLCAD2	11.6
Lung	RERFLCAI	12
Lung	RERFLCKJ	10.8
Lung	RERFLCMS	11.2
Lung	RERFLCSQ1	12
Lung	SBC5	11.1
Lung	SCLC21H	11.4
Lung	SHP77	11.8
Lung	SKLU1	12.3
Lung	SKMES1	11.4
Lung	SQ1	11.2
Lung	SW1271	12.3
Lung	SW1573	12.3
Lung	SW900	12.3
Lung	VMRCLCD	11.4
Lung	VMRCLCP	11.1
Oesophagus	COLO680N	10.8
Oesophagus	ECGI10	10
Oesophagus	KYSE140	11.7
Oesophagus	KYSE150	11.9
Oesophagus	KYSE180	12
Oesophagus	KYSE270	10.8
Oesophagus	KYSE30	10.8
Oesophagus	KYSE410	11.6
Oesophagus	KYSE450	11.4
Oesophagus	KYSE510	12.4
Oesophagus	KYSE520	11.9
Oesophagus	KYSE70	10.8
Oesophagus	OE19	11.6
Oesophagus	OE33	10.4
Oesophagus	TE10	11.3
Oesophagus	TE11	11.3
Oesophagus	TE14	11.3
Oesophagus	TE15	11
Oesophagus	TE1	11.6
Oesophagus	TE4	11.2
Oesophagus	TE5	10.4
Oesophagus	TE6	11.6
Oesophagus	TE8	11.5
Oesophagus	TE9	11.6
Oesophagus	TT	10.6
Ovary	59M	11.9
Ovary	A2780	11.5
Ovary	CAOV3	10.8
Ovary	CAOV4	11.7
Ovary	COLO704	12
Ovary	COV318	10.7
Ovary	COV362	10.7
Ovary	COV434	11
Ovary	COV504	11
Ovary	COV644	10.8
Ovary	EFO21	10.6
Ovary	EFO27	11.9
Ovary	ES2	11.6
Ovary	FUOV1	11.5
Ovary	HEYA8	12.1
Ovary	HS571T	10.5
Ovary	IGROV1	11.8
Ovary	JHOC5	11.6
Ovary	JHOM1	11.5
Ovary	JHOM2B	10.2
Ovary	JHOS2	10.4
Ovary	JHOS4	11.8
Ovary	KURAMOCHI	10.5
Ovary	MCAS	11.4
Ovary	NIHOVCAR3	11.3
Ovary	OAW28	11.5
Ovary	OAW42	12.3
Ovary	OC314	11.7
Ovary	OC316	11.8
Ovary	ONCODG1	11.3
Ovary	OV56	11.2
Ovary	OV7	11.9
Ovary	OV90	11.7
Ovary	OVCAR4	11.9
Ovary	OVCAR8	11.7
Ovary	OVISE	11.5
Ovary	OVK18	11.2
Ovary	OVKATE	10.6
Ovary	OVMANA	11.1
Ovary	OVSAHO	11
Ovary	OVTOKO	11.4
Ovary	RMGI	11.7
Ovary	RMUGS	12.6
Ovary	SKOV3	11.5
Ovary	SNU119	11.6
Ovary	SNU840	12
Ovary	SNU8	12.3
Ovary	TOV112D	11.5
Ovary	TOV21G	11.8
Ovary	TYKNU	11.7
Pancreas	ASPC1	10.1
Pancreas	BXPC3	12.2
Pancreas	CAPAN1	11.9
Pancreas	CAPAN2	11.5
Pancreas	CFPAC1	11.3
Pancreas	DANG	11.4
Pancreas	HPAC	11.1
Pancreas	HPAFII	11.1
Pancreas	HS766T	11.1
Pancreas	HUPT3	11.2
Pancreas	HUPT4	11
Pancreas	KCIMOH1	11.3
Pancreas	KLM1	11.9
Pancreas	KP2	10.9
Pancreas	KP3	10.8
Pancreas	KP4	11.1
Pancreas	L33	11.9
Pancreas	MIAPACA2	12.2
Pancreas	PANC0203	11.4
Pancreas	PANC0213	9.9
Pancreas	PANC0327	11.1
Pancreas	PANC0403	11.1
Pancreas	PANC0504	11.1
Pancreas	PANC0813	11.1
Pancreas	PANC1005	12
Pancreas	PANC1	11.7
Pancreas	PATU8902	11.5
Pancreas	PATU8988S	11.2
Pancreas	PATU8988T	11.4
Pancreas	PK1	12.1
Pancreas	PK45H	11.1
Pancreas	PK59	11.5
Pancreas	PL45	11.7
Pancreas	PSN1	11.8
Pancreas	QGP1	10.7
Pancreas	SNU213	10.6
Pancreas	SNU324	11.3
Pancreas	SNU410	11.7
Pancreas	SU8686	9.9
Pancreas	SUIT2	10.9
Pancreas	SW1990	12.2
Pancreas	T3M4	10.8
Pancreas	TCCPAN2	11.8
Pancreas	YAPC	10.7
Pleura	ACCMESO1	11.3
Pleura	DM3	11.1
Pleura	ISTMES1	11.5
Pleura	ISTMES2	11.8
Pleura	JL1	11.6
Pleura	MPP89	12.1
Pleura	MSTO211H	12.2
Pleura	NCIH2052	11.7
Pleura	NCIH2452	10.6
Pleura	NCIH28	11.3
Prostate	22RV1	11.4
Prostate	DU145	11.9
Prostate	LNCAPCLONEFGC	10.5
Prostate	MDAPCA2B	10.9
Prostate	NCIH660	10
Prostate	PC3	10.7
Prostate	VCAP	10.9
Salivary gland	A253	11.4
Salivary gland	YD15	11
Skin	A101D	11.9
Skin	A2058	12.1
Skin	A375	12.4
Skin	C32	10.7
Skin	CHL1	10.8
Skin	CJM	10.7
Skin	COLO679	11.1
Skin	COLO741	11.2
Skin	COLO783	11.4
Skin	COLO792	10.8
Skin	COLO800	10.9
Skin	COLO818	10.3
Skin	COLO829	10.7
Skin	COLO849	11.6
Skin	G361	12.2
Skin	GRM	12.3
Skin	HMCB	10.9
Skin	HS294T	11.9
Skin	HS600T	10.6
Skin	HS688AT	10.7
Skin	HS695T	11.5
Skin	HS839T	10.9
Skin	HS852T	10.8
Skin	HS895T	10.4
Skin	HS934T	10.8
Skin	HS936T	10.2
Skin	HS939T	11
Skin	HS940T	10.5
Skin	HS944T	12.4
Skin	HT144	12.1
Skin	IGR1	11.8
Skin	IGR37	11.8
Skin	IGR39	12.1
Skin	IPC298	11.2
Skin	K029AX	11.4
Skin	LOXIMVI	11.8
Skin	MALME3M	10.7
Skin	MDAMB435S	11.7
Skin	MELHO	11.1
Skin	MELJUSO	12.1
Skin	MEWO	11.7
Skin	RPMI7951	12
Skin	RVH421	11.2
Skin	SH4	10.6
Skin	SKMEL1	11.3
Skin	SKMEL24	11.1
Skin	SKMEL28	11.2
Skin	SKMEL2	11.2
Skin	SKMEL30	10.6
Skin	SKMEL31	10.6
Skin	SKMEL3	11.2
Skin	SKMEL5	11.6
Skin	UACC257	11.9
Skin	UACC62	12.2
Skin	WM115	11.1
Skin	WM1799	11.3
Skin	WM2664	10.8
Skin	WM793	11.1
Skin	WM88	11.5
Skin	WM983B	11.1
Small intestine	HUTU80	11.2
Soft tissue	A204	11.9
Soft tissue	G401	12.2
Soft tissue	G402	11.5
Soft tissue	GCT	11.8
Soft tissue	HS729	11
Soft tissue	HT1080	12.2
Soft tissue	KYM1	10.9
Soft tissue	MESSA	12.2
Soft tissue	RD	11.5
Soft tissue	RH30	12.1
Soft tissue	RH41	11.8
Soft tissue	RKN	11.4
Soft tissue	S117	11.7
Soft tissue	SJRH30	11.4
Soft tissue	SKLMS1	11.7
Soft tissue	SKUT1	12.1
Soft tissue	TE125T	10
Soft tissue	TE159T	10.4
Soft tissue	TE441T	11.1
Soft tissue	TE617T	11
Stomach	2313287	10.7
Stomach	AGS	11.7
Stomach	AZ521	11.5
Stomach	ECC10	11.2
Stomach	ECC12	11.1
Stomach	FU97	11.3
Stomach	GCIY	12.6
Stomach	GSS	11.3
Stomach	GSU	11
Stomach	HGC27	11.8
Stomach	HS746T	11.1
Stomach	HUG1N	10.8
Stomach	IM95	11.4
Stomach	KATOIII	11.4
Stomach	KE39	11.4
Stomach	LMSU	11.8
Stomach	MKN1	11.1
Stomach	MKN45	11.9
Stomach	MKN74	10.5
Stomach	MKN7	11.9
Stomach	NCCSTCK140	11.8
Stomach	NCIN87	12.4
Stomach	NUGC2	11.5
Stomach	NUGC3	11.4
Stomach	NUGC4	10.2
Stomach	OCUM1	11
Stomach	RERFGC1B	12
Stomach	SH10TC	11.8
Stomach	SNU16	11.9
Stomach	SNU1	11.5
Stomach	SNU216	11.4
Stomach	SNU520	10.8
Stomach	SNU5	11.6
Stomach	SNU601	12.3
Stomach	SNU620	11.6
Stomach	SNU668	11.9
Stomach	SNU719	11.3
Stomach	TGBC11TKB	11.2
Thyroid	8305C	12
Thyroid	8505C	11.8
Thyroid	BCPAP	12.1
Thyroid	BHT101	10.6
Thyroid	CAL62	11.8
Thyroid	CGTHW1	11.9
Thyroid	FTC133	12.8
Thyroid	FTC238	11.8
Thyroid	ML1	11.2
Thyroid	SW579	11.7
Thyroid	TT2609C02	12
Thyroid	TT	11.1
Upper aerodigestive tract	BHY	10.3
Upper aerodigestive tract	BICR16	12
Upper aerodigestive tract	BICR18	11
Upper aerodigestive tract	BICR22	10.6
Upper aerodigestive tract	BICR31	10.9
Upper aerodigestive tract	BICR56	10.9
Upper aerodigestive tract	BICR6	11.4
Upper aerodigestive tract	CAL27	11.4
Upper aerodigestive tract	CAL33	11
Upper aerodigestive tract	DETROIT562	10.9
Upper aerodigestive tract	FADU	12
Upper aerodigestive tract	HS840T	11.1
Upper aerodigestive tract	HSC2	10.8
Upper aerodigestive tract	HSC3	11.2
Upper aerodigestive tract	HSC4	10.2
Upper aerodigestive tract	PECAPJ15	11.4
Upper aerodigestive tract	PECAPJ34CLONEC12	11.8
Upper aerodigestive tract	PECAPJ41CLONED2	11.7
Upper aerodigestive tract	PECAPJ49	11.9
Upper aerodigestive tract	SCC15	11.4
Upper aerodigestive tract	SCC25	11
Upper aerodigestive tract	SCC4	11.3
Upper aerodigestive tract	SCC9	11.4
Upper aerodigestive tract	SNU1076	10.7
Upper aerodigestive tract	SNU1214	11.2
Upper aerodigestive tract	SNU46	12.2
Upper aerodigestive tract	SNU899	10.5
Upper aerodigestive tract	YD10B	10.5
Upper aerodigestive tract	YD38	11.4
Upper aerodigestive tract	YD8	10.9
Urinary tract	5637	11.8
Urinary tract	639V	12.5
Urinary tract	647V	11.6
Urinary tract	BC3C	11.4
Urinary tract	BFTC905	11.4
Urinary tract	CAL29	11.2
Urinary tract	HS172T	9.9
Urinary tract	HT1197	10.9
Urinary tract	HT1376	10.4
Urinary tract	J82	12.2
Urinary tract	JMSU1	12.2
Urinary tract	KMBC2	10.1
Urinary tract	KU1919	11.6
Urinary tract	RT11284	11.7
Urinary tract	RT112	11.7
Urinary tract	RT4	11.4
Urinary tract	SCABER	11.3
Urinary tract	SW1710	11.5
Urinary tract	SW780	11.7
Urinary tract	T24	11.8
Urinary tract	TCCSUP	10.5
Urinary tract	UMUC1	11.4
Urinary tract	UMUC3	12.3
Urinary tract	VMCUB1	11.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	7
Adrenal gland	2.6
Appendix	9.8
Bone marrow	8.7
Breast	3.5
Cerebral cortex	11.9
Cervix, uterine	3.5
Colon	9
Duodenum	10.6
Endometrium	9.7
Epididymis	1
Esophagus	15.7
Fallopian tube	7.2
Gallbladder	7
Heart muscle	4.1
Kidney	6.8
Liver	2.3
Lung	6.7
Lymph node	9.5
Ovary	5.4
Pancreas	1.6
Parathyroid gland	1.4
Placenta	5.1
Prostate	6.6
Rectum	2.6
Salivary gland	3.1
Seminal vesicle	7.5
Skeletal muscle	10.2
Skin	5.3
Small intestine	10.5
Smooth muscle	2
Spleen	8.7
Stomach	9.4
Testis	71.6
Thyroid gland	12.3
Tonsil	2.7
Urinary bladder	6.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
22341977	Overexpression	Renal Cell Carcinoma	Reptin is overexpressed in cancerous tissues compared with tumor adjacent renal tissues. Cytoplasmic expression of reptin positively correlates with the poor differentiation of RCC, and predicts an unfavorable outcome for patients.
20888340	Overexpression	Breast Carcinoma	Reptin was also shown to be overproduced in a panel of primary breast cancer biopsy specimens, relative to normal adjacent tissue from the same patient, suggesting a role in cancer growth in vivo.
19877184	Overexpression	Hepatocellular Carcinoma	We found that Reptin was up-regulated in hepatocellular carcinoma (HCC) and that down-regulation of Reptin led to growth arrest.
17657734	Overexpression	Hepatocellular Carcinoma	RUVBL2 is overexpressed in a large majority of HCCs. RUVBL2 overexpression enhances tumorigenicity, and RUVBL2 is required for tumor cell viability.

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.375	5.96e-15	15.6	46.5	37.9	Gain
BRCA	Breast invasive carcinoma	1075	0.374	4.41e-37	18	59.8	22.1	Neutral
CESC	Cervical and endocervical cancers	292	0.554	6.72e-25	12	59.9	28.1	Neutral
COAD	Colon adenocarcinoma	449	0.278	2.13e-09	9.6	71.7	18.7	Neutral
ESCA	Esophageal carcinoma	183	0.389	5.43e-08	26.2	47	26.8	Neutral
GBM	Glioblastoma multiforme	147	0.655	2.23e-19	17.7	58.5	23.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.345	7.54e-16	18.7	66	15.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.202	3.25e-06	1.1	88.2	10.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.11	0.0618	6.2	92.4	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.126	0.106	2.4	94.6	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.652	2.4e-63	50.1	45.4	4.5	Loss
LIHC	Liver hepatocellular carcinoma	364	0.44	1.25e-18	10.7	68.4	20.9	Neutral
LUAD	Lung adenocarcinoma	512	0.306	1.36e-12	36.7	48.4	14.8	Loss
LUSC	Lung squamous cell carcinoma	498	0.543	1.38e-39	28.3	39.4	32.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.568	4.97e-27	49	32	19	Loss
PAAD	Pancreatic adenocarcinoma	177	0.431	2.07e-09	11.9	70.6	17.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.292	0.000163	4.9	87	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.223	6.14e-07	6.9	90.2	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.408	6e-08	14	67.1	18.9	Neutral
SARC	Sarcoma	255	0.401	2.71e-11	32.5	48.2	19.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.333	5.71e-11	21.5	63.5	15	Neutral
STAD	Stomach adenocarcinoma	413	0.416	1.03e-18	16.9	59.3	23.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.24	0.00307	38.7	43.3	18	Loss
THCA	Thyroid carcinoma	497	0.202	5.96e-06	0.2	97.8	2	Neutral
THYM	Thymoma	119	0.038	0.681	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.315	7.32e-14	11.4	78.2	10.4	Neutral

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.132	0.00632	17	408	-0.002	0.0172	NS/NA
BRCA	Breast invasive carcinoma	-0.161	1.94e-06	83	785	-0.002	0.0199	NS/NA
CESC	Cervical and endocervical cancers	-0.086	0.133	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.151	0.00733	19	297	0.001	0.00114	NS/NA
ESCA	Esophageal carcinoma	-0.18	0.0123	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.198	0.115	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.082	0.0568	20	522	0.001	0.59	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.259	1.32e-06	24	319	0.001	0.0892	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.169	0.00355	23	275	-0.002	0.145	NS/NA
LAML	Acute Myeloid Leukemia	-0.117	0.128	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.365	5.11e-20	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.158	0.00127	41	373	-0.002	0.00224	NS/NA
LUAD	Lung adenocarcinoma	-0.14	0.00219	21	456	-0.002	0.763	NS/NA
LUSC	Lung squamous cell carcinoma	-0.312	6.98e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.717	0.0369	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.317	1.4e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.091	0.218	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.154	0.00038	35	498	0.001	0.384	NS/NA
READ	Rectum adenocarcinoma	-0.094	0.348	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.252	3.74e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.165	0.000319	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.111	0.0326	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.136	0.09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.085	0.0443	50	509	-0.002	0.00241	NS/NA
THYM	Thymoma	-0.227	0.0122	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.11	0.0182	34	431	0	0.405	NS/NA

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.647	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000569	Significant	23000897
COAD	Colon adenocarcinoma	149	0.688	NS	22810696
GBM	Glioblastoma multiforme	157	0.00623	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00521	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.158	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.84e-30	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00106	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00113	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.381	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.057	NS	26544944
READ	Rectum adenocarcinoma	67	0.879	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.559	NS	26091043
STAD	Stomach adenocarcinoma	277	3.45e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.000222	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.294	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.044	0.84	NS
BRCA	Breast invasive carcinoma	1079	1.043	0.86	NS
CESC	Cervical and endocervical cancers	291	0.876	0.693	NS
COAD	Colon adenocarcinoma	439	0.845	0.55	NS
ESCA	Esophageal carcinoma	184	1.12	0.713	NS
GBM	Glioblastoma multiforme	158	0.84	0.489	NS
HNSC	Head and Neck squamous cell carcinoma	518	2.025	0.000441	Shorter
KIRC	Kidney renal clear cell carcinoma	531	2.262	0.00033	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.953	0.901	NS
LAML	Acute Myeloid Leukemia	149	1.045	0.89	NS
LGG	Brain Lower Grade Glioma	511	2.525	0.000666	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.225	0.404	NS
LUAD	Lung adenocarcinoma	502	1.574	0.0418	Shorter
LUSC	Lung squamous cell carcinoma	494	0.943	0.767	NS
OV	Ovarian serous cystadenocarcinoma	303	0.83	0.372	NS
PAAD	Pancreatic adenocarcinoma	177	0.883	0.673	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.449	0.503	NS
PRAD	Prostate adenocarcinoma	497	574565094.369	0.165	NS
READ	Rectum adenocarcinoma	159	1.263	0.676	NS
SARC	Sarcoma	259	2.034	0.0229	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.691	0.00547	Shorter
STAD	Stomach adenocarcinoma	388	0.872	0.54	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.176	NS
THCA	Thyroid carcinoma	500	0.585	0.459	NS
THYM	Thymoma	119	0.354	0.347	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.79	0.434	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.043	0.383	NS
BRCA	Breast invasive carcinoma	1071	0.045	0.139	NS
CESC	Cervical and endocervical cancers	167	-0.024	0.758	NS
COAD	Colon adenocarcinoma	445	-0.076	0.108	NS
ESCA	Esophageal carcinoma	162	-0.036	0.653	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.117	0.013	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.186	1.61e-05	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.108	0.0833	NS
LIHC	Liver hepatocellular carcinoma	347	0.029	0.588	NS
LUAD	Lung adenocarcinoma	507	0.103	0.0204	Higher
LUSC	Lung squamous cell carcinoma	497	0.082	0.0678	NS
OV	Ovarian serous cystadenocarcinoma	302	0.001	0.989	NS
PAAD	Pancreatic adenocarcinoma	176	-0.066	0.386	NS
READ	Rectum adenocarcinoma	156	-0.066	0.414	NS
SKCM	Skin Cutaneous Melanoma	410	-0.022	0.655	NS
STAD	Stomach adenocarcinoma	392	-0.041	0.421	NS
TGCT	Testicular Germ Cell Tumors	81	0.011	0.919	NS
THCA	Thyroid carcinoma	499	0.046	0.305	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.085	0.057	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.169	0.0052	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.019	0.678	NS
KIRC	Kidney renal clear cell carcinoma	525	0.245	1.29e-08	Higher
LGG	Brain Lower Grade Glioma	514	0.083	0.0611	NS
LIHC	Liver hepatocellular carcinoma	366	0.088	0.0911	NS
OV	Ovarian serous cystadenocarcinoma	296	0.057	0.328	NS
PAAD	Pancreatic adenocarcinoma	176	0.056	0.457	NS
STAD	Stomach adenocarcinoma	406	-0.059	0.236	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.056	0.194	NS

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for RUVBL2.

Summary
Symbol	RUVBL2
Name	RuvB like AAA ATPase 2
Aliases	RVB2; TIP48; TIP49b; Reptin52; ECP51; TIH2; INO80J; reptin; RuvB (E coli homolog)-like 2; RuvB-like 2 (E. co ......
Location	19q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25609707	Breast Carcinoma; Prostate Carcinoma; Osteoscaroma	partner	RUNX2	Interaction	We used proteomic analysis to identify RUNX2-dependent protein-protein interactions associated with the nuclear matrix in bone, breast and prostate tumor cell types and found that RUNX2 interacts with three distinct proteins that respond to DNA damage - RUVBL2, INTS3 and BAZ1B.
24786788	Breast Carcinoma	partner	MTBP	Interaction	Mechanistic investigations implicated associations with TIP48/TIP49 as well as MYC in MTBP function in cellular transformation and the growth of human breast cancer cells.