CR2Cancer

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02146 Sir2 family

Function

NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0006091 generation of precursor metabolites and energy GO:0006473 protein acetylation GO:0006476 protein deacetylation GO:0007568 aging GO:0009060 aerobic respiration GO:0009306 protein secretion GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0015980 energy derivation by oxidation of organic compounds GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0018394 peptidyl-lysine acetylation GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0032024 positive regulation of insulin secretion GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0042326 negative regulation of phosphorylation GO:0042886 amide transport GO:0043409 negative regulation of MAPK cascade GO:0043543 protein acylation GO:0045333 cellular respiration GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070932 histone H3 deacetylation GO:0072593 reactive oxygen species metabolic process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0098732 macromolecule deacylation GO:1901983 regulation of protein acetylation GO:1901984 negative regulation of protein acetylation GO:1902532 negative regulation of intracellular signal transduction GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000756 regulation of peptidyl-lysine acetylation GO:2000757 negative regulation of peptidyl-lysine acetylation
Molecular Function	GO:0004407 histone deacetylase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0070403 NAD+ binding
Cellular Component	GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1225796	c.1154A>C	p.D385A	Substitution - Missense	Large_intestine
COSM4513840	c.952C>T	p.L318F	Substitution - Missense	Skin
COSM4456590	c.1015C>T	p.P339S	Substitution - Missense	Skin
COSM5765023	c.477G>T	p.S159S	Substitution - coding silent	Large_intestine
COSM4803898	c.480G>T	p.P160P	Substitution - coding silent	Liver
COSM1225795	c.45G>T	p.W15C	Substitution - Missense	Large_intestine
COSM2152837	c.516T>G	p.D172E	Substitution - Missense	Central_nervous_system
COSM3446371	c.504C>T	p.L168L	Substitution - coding silent	Skin
COSM926018	c.561C>A	p.H187Q	Substitution - Missense	Endometrium
COSM4425803	c.808-4C>G	p.?	Unknown	Oesophagus
COSM376559	c.978T>G	p.P326P	Substitution - coding silent	Lung
COSM3809005	c.785C>T	p.P262L	Substitution - Missense	Breast
COSM3446370	c.505C>T	p.Q169*	Substitution - Nonsense	Skin
COSM4622043	c.986G>A	p.S329N	Substitution - Missense	Large_intestine
COSM5503692	c.916G>A	p.V306M	Substitution - Missense	Biliary_tract
COSM5422416	c.983C>T	p.A328V	Substitution - Missense	Prostate
COSM925965	c.1034G>A	p.R345Q	Substitution - Missense	Endometrium
COSM687686	c.649C>A	p.H217N	Substitution - Missense	Lung
COSM1353192	c.1107C>T	p.G369G	Substitution - coding silent	Large_intestine
COSM5661407	c.1129C>T	p.L377L	Substitution - coding silent	Soft_tissue
COSM1242845	c.540delT	p.F180fs*93	Deletion - Frameshift	Oesophagus
COSM4745661	c.6G>A	p.A2A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5765078	c.561C>T	p.H187H	Substitution - coding silent	Large_intestine
COSM687723	c.1167G>T	p.R389R	Substitution - coding silent	Lung
COSM4726198	c.513C>T	p.Y171Y	Substitution - coding silent	Large_intestine
COSM926004	c.856G>A	p.V286I	Substitution - Missense	Endometrium
COSM2112499	c.1033C>T	p.R345W	Substitution - Missense	Large_intestine
COSM5050732	c.1108G>A	p.V370M	Substitution - Missense	Stomach
COSM315204	c.399G>T	p.R133R	Substitution - coding silent	Lung
COSM3809001	c.874G>T	p.V292L	Substitution - Missense	Breast
COSM5372276	c.723C>T	p.A241A	Substitution - coding silent	Skin
COSM5554036	c.574T>C	p.F192L	Substitution - Missense	Prostate
COSM2152837	c.516T>G	p.D172E	Substitution - Missense	Central_nervous_system
COSM5703958	c.446G>A	p.S149N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM6014191	c.197C>T	p.P66L	Substitution - Missense	Skin
COSM4745660	c.7T>G	p.F3V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5769948	c.24C>T	p.A8A	Substitution - coding silent	Breast
COSM5761912	c.1165C>T	p.R389W	Substitution - Missense	Pancreas
COSM925966	c.996G>T	p.E332D	Substitution - Missense	Endometrium
COSM2112483	c.1126C>A	p.L376I	Substitution - Missense	Large_intestine
COSM1353212	c.872T>G	p.I291S	Substitution - Missense	Large_intestine
COSM925965	c.1034G>A	p.R345Q	Substitution - Missense	Prostate
COSM4803898	c.480G>T	p.P160P	Substitution - coding silent	Liver
COSM5920274	c.371C>T	p.S124F	Substitution - Missense	Skin
COSM395442	c.659G>T	p.G220V	Substitution - Missense	Lung
COSM5669896	c.172G>T	p.G58C	Substitution - Missense	Soft_tissue
COSM27254	c.1179G>A	p.K393K	Substitution - coding silent	Urinary_tract
COSM4929696	c.724T>G	p.S242A	Substitution - Missense	Liver
COSM1353249	c.322G>A	p.A108T	Substitution - Missense	Large_intestine
COSM926019	c.366G>T	p.K122N	Substitution - Missense	Endometrium
COSM4425802	c.969+7C>T	p.?	Unknown	Oesophagus
COSM1746181	c.1037A>T	p.D346V	Substitution - Missense	Urinary_tract
COSM5769948	c.24C>T	p.A8A	Substitution - coding silent	Breast
COSM1703303	c.292G>A	p.G98R	Substitution - Missense	Skin
COSM1321732	c.1168G>A	p.E390K	Substitution - Missense	Ovary
COSM5784678	c.198C>T	p.P66P	Substitution - coding silent	Breast
COSM1353244	c.455G>A	p.S152N	Substitution - Missense	Large_intestine
COSM4574282	c.552C>T	p.F184F	Substitution - coding silent	Bone
COSM347798	c.1080G>T	p.V360V	Substitution - coding silent	Lung
COSM1321725	c.120T>A	p.L40L	Substitution - coding silent	Ovary
COSM3935422	c.1104C>T	p.H368H	Substitution - coding silent	Oesophagus
COSM4430904	c.176A>C	p.E59A	Substitution - Missense	Oesophagus
COSM1746181	c.1037A>T	p.D346V	Substitution - Missense	Urinary_tract
COSM4574277	c.985A>G	p.S329G	Substitution - Missense	Bone
COSM1287936	c.793G>T	p.G265W	Substitution - Missense	Autonomic_ganglia
COSM1475340	c.490C>A	p.L164M	Substitution - Missense	Breast
COSM5811728	c.173G>A	p.G58D	Substitution - Missense	Liver
COSM4651916	c.1150C>A	p.R384R	Substitution - coding silent	Large_intestine
COSM6014190	c.879C>G	p.F293L	Substitution - Missense	Skin
COSM3446369	c.529G>A	p.E177K	Substitution - Missense	Skin
COSM1167866	c.636_637insT	p.L213fs*6	Insertion - Frameshift	Skin

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
23800187	mutation (loss of function)	Oral Cavity Squamous Cell Carcinoma	We also sequenced the entire coding region of SIRT3 and found the same mutation in 2 different OSCC cell lines. This point mutation is located in close proximity to the active site of deacetylase in the SIRT3 protein, and reduces the overall enzymatic efficiency of deacetylation.
28560068	Underexpression; Mutation	Breast Carcinoma	We demonstrated that HDAC2 and SIRT7 were the most commonly amplified/overexpressed, and SIRT3 was most deleted/underexpressed, particularly in aggressive basal-like breast cancer.

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.668	4.779	0.099	0.529	NS
BRCA	Breast invasive carcinoma	112	1100	5.203	5.176	-0.058	0.37	NS
CESC	Cervical and endocervical cancers	3	306	5.482	4.625	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.783	4.762	-0.022	0.741	NS
ESCA	Esophageal carcinoma	11	185	4.585	4.352	-0.174	0.378	NS
GBM	Glioblastoma multiforme	5	166	5.778	5.453	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.414	4.477	-0.08	0.464	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.348	5.345	0.07	0.163	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.491	5.991	0.427	6e-06	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.765	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.621	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.307	5.015	-0.294	0.00075	NS
LUAD	Lung adenocarcinoma	59	517	4.819	4.926	0.175	0.00908	NS
LUSC	Lung squamous cell carcinoma	51	501	4.716	4.63	-0.076	0.249	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.941	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.817	4.792	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.231	5.261	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.195	5.284	0.14	0.0291	NS
READ	Rectum adenocarcinoma	10	167	4.569	4.847	0.291	0.0701	NS
SARC	Sarcoma	2	263	5.413	4.849	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.917	4.79	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.339	4.487	0.148	0.118	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.574	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.146	5.29	0.193	0.000754	NS
THYM	Thymoma	2	120	5.004	5.24	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.267	5.407	0.168	0.0818	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.9
Autonomic ganglia	CHP212	6.2
Autonomic ganglia	IMR32	6.3
Autonomic ganglia	KELLY	6.1
Autonomic ganglia	KPNRTBM1	6.8
Autonomic ganglia	KPNSI9S	6.7
Autonomic ganglia	KPNYN	6.8
Autonomic ganglia	MHHNB11	6.8
Autonomic ganglia	NB1	6.5
Autonomic ganglia	NH6	6.8
Autonomic ganglia	SHSY5Y	6.8
Autonomic ganglia	SIMA	6.3
Autonomic ganglia	SKNAS	6.7
Autonomic ganglia	SKNBE2	6.5
Autonomic ganglia	SKNDZ	6.7
Autonomic ganglia	SKNFI	6.6
Autonomic ganglia	SKNSH	6.5
Biliary tract	HUCCT1	6.4
Biliary tract	HUH28	6.5
Biliary tract	SNU1079	7.1
Biliary tract	SNU1196	6.9
Biliary tract	SNU245	6.8
Biliary tract	SNU308	6.6
Biliary tract	SNU478	7.1
Bone	143B	6.6
Bone	A673	6.8
Bone	CADOES1	7
Bone	CAL78	7.3
Bone	G292CLONEA141B1	6.3
Bone	HOS	6.6
Bone	HS706T	6.5
Bone	HS737T	6.5
Bone	HS819T	6.4
Bone	HS821T	6.5
Bone	HS822T	6.6
Bone	HS863T	6.4
Bone	HS870T	6.5
Bone	HS888T	6.5
Bone	MG63	6.6
Bone	MHHES1	6.6
Bone	OUMS27	6.5
Bone	RDES	7.3
Bone	SJSA1	6.4
Bone	SKES1	6.4
Bone	SKNMC	6.4
Bone	SW1353	6.6
Bone	T173	6.5
Bone	TC71	6.8
Bone	U2OS	6.5
Breast	AU565	6.9
Breast	BT20	7
Breast	BT474	6.6
Breast	BT483	7
Breast	BT549	6.3
Breast	CAL120	6.6
Breast	CAL148	7.8
Breast	CAL51	7.2
Breast	CAL851	6.2
Breast	CAMA1	6.9
Breast	DU4475	6.9
Breast	EFM192A	6.6
Breast	EFM19	6.8
Breast	EVSAT	7.3
Breast	HCC1143	6.4
Breast	HCC1187	6.7
Breast	HCC1395	6.6
Breast	HCC1419	7.2
Breast	HCC1428	5.8
Breast	HCC1500	5.9
Breast	HCC1569	6.6
Breast	HCC1599	6.8
Breast	HCC1806	5.7
Breast	HCC1937	6.3
Breast	HCC1954	6.4
Breast	HCC202	7.5
Breast	HCC2157	7
Breast	HCC2218	7.3
Breast	HCC38	6.1
Breast	HCC70	6.1
Breast	HDQP1	6.9
Breast	HMC18	7.3
Breast	HS274T	6.5
Breast	HS281T	6.3
Breast	HS343T	6.4
Breast	HS578T	6.2
Breast	HS606T	6.7
Breast	HS739T	6.6
Breast	HS742T	6.5
Breast	JIMT1	6.1
Breast	KPL1	6.7
Breast	MCF7	6.2
Breast	MDAMB134VI	7.4
Breast	MDAMB157	6.7
Breast	MDAMB175VII	7.2
Breast	MDAMB231	6.5
Breast	MDAMB361	6.1
Breast	MDAMB415	7.2
Breast	MDAMB436	6.3
Breast	MDAMB453	7.5
Breast	MDAMB468	6.6
Breast	SKBR3	6.8
Breast	T47D	6.8
Breast	UACC812	7.5
Breast	UACC893	7
Breast	YMB1	6.5
Breast	ZR751	6.1
Breast	ZR7530	7.2
Central nervous system	1321N1	6.7
Central nervous system	42MGBA	6.1
Central nervous system	8MGBA	6.5
Central nervous system	A172	6.9
Central nervous system	AM38	6.7
Central nervous system	BECKER	7
Central nervous system	CAS1	6.5
Central nervous system	CCFSTTG1	6.3
Central nervous system	D283MED	7
Central nervous system	D341MED	7
Central nervous system	DAOY	6.4
Central nervous system	DBTRG05MG	6.8
Central nervous system	DKMG	6.3
Central nervous system	GAMG	6.6
Central nervous system	GB1	6.5
Central nervous system	GI1	6.4
Central nervous system	GMS10	6.5
Central nervous system	GOS3	7.2
Central nervous system	H4	6.8
Central nervous system	HS683	6.5
Central nervous system	KALS1	6.2
Central nervous system	KG1C	6.4
Central nervous system	KNS42	6.4
Central nervous system	KNS60	6.8
Central nervous system	KNS81	6.5
Central nervous system	KS1	6.6
Central nervous system	LN18	6.6
Central nervous system	LN229	6.4
Central nervous system	M059K	6.9
Central nervous system	MOGGCCM	6.3
Central nervous system	MOGGUVW	6.3
Central nervous system	NMCG1	6.3
Central nervous system	ONS76	7.4
Central nervous system	SF126	6.9
Central nervous system	SF295	6.5
Central nervous system	SNB19	6.2
Central nervous system	SNU1105	6.5
Central nervous system	SNU201	7
Central nervous system	SNU466	6.8
Central nervous system	SNU489	7.1
Central nervous system	SNU626	6.7
Central nervous system	SNU738	6.8
Central nervous system	SW1088	6.7
Central nervous system	SW1783	6.3
Central nervous system	T98G	7.2
Central nervous system	TM31	6.2
Central nervous system	U118MG	6.5
Central nervous system	U138MG	6.7
Central nervous system	U251MG	6.6
Central nervous system	U87MG	6.5
Central nervous system	YH13	6
Central nervous system	YKG1	6.2
Endometrium	AN3CA	7.7
Endometrium	COLO684	7
Endometrium	EFE184	6.7
Endometrium	EN	7.2
Endometrium	ESS1	6.5
Endometrium	HEC108	7.1
Endometrium	HEC151	6.6
Endometrium	HEC1A	6.5
Endometrium	HEC1B	6.8
Endometrium	HEC251	6.5
Endometrium	HEC265	6.8
Endometrium	HEC50B	6.6
Endometrium	HEC59	6.8
Endometrium	HEC6	6.7
Endometrium	ISHIKAWAHERAKLIO02ER	6.6
Endometrium	JHUEM1	6.7
Endometrium	JHUEM2	7.2
Endometrium	JHUEM3	6.4
Endometrium	KLE	6.7
Endometrium	MFE280	6.7
Endometrium	MFE296	7.3
Endometrium	MFE319	7.2
Endometrium	RL952	6.9
Endometrium	SNGM	7.3
Endometrium	SNU1077	6.8
Endometrium	SNU685	6.9
Endometrium	TEN	6.3
Haematopoietic and lymphoid	697	6.7
Haematopoietic and lymphoid	A3KAW	7.2
Haematopoietic and lymphoid	A4FUK	7.3
Haematopoietic and lymphoid	ALLSIL	6.7
Haematopoietic and lymphoid	AML193	6.5
Haematopoietic and lymphoid	AMO1	7
Haematopoietic and lymphoid	BCP1	7.1
Haematopoietic and lymphoid	BDCM	6.7
Haematopoietic and lymphoid	BL41	6.7
Haematopoietic and lymphoid	BL70	6.8
Haematopoietic and lymphoid	BV173	6.6
Haematopoietic and lymphoid	CA46	7.2
Haematopoietic and lymphoid	CI1	6.9
Haematopoietic and lymphoid	CMK115	6.1
Haematopoietic and lymphoid	CMK86	7
Haematopoietic and lymphoid	CMK	6.6
Haematopoietic and lymphoid	CMLT1	6.8
Haematopoietic and lymphoid	COLO775	7.2
Haematopoietic and lymphoid	DAUDI	6.4
Haematopoietic and lymphoid	DB	7.5
Haematopoietic and lymphoid	DEL	6.6
Haematopoietic and lymphoid	DND41	6.9
Haematopoietic and lymphoid	DOHH2	6.8
Haematopoietic and lymphoid	EB1	7.3
Haematopoietic and lymphoid	EB2	7.3
Haematopoietic and lymphoid	EHEB	7.1
Haematopoietic and lymphoid	EJM	6.5
Haematopoietic and lymphoid	EM2	6.7
Haematopoietic and lymphoid	EOL1	6.9
Haematopoietic and lymphoid	F36P	6.8
Haematopoietic and lymphoid	GA10	6.6
Haematopoietic and lymphoid	GDM1	7.1
Haematopoietic and lymphoid	GRANTA519	6.9
Haematopoietic and lymphoid	HDLM2	7.2
Haematopoietic and lymphoid	HDMYZ	6.3
Haematopoietic and lymphoid	HEL9217	6.4
Haematopoietic and lymphoid	HEL	6.6
Haematopoietic and lymphoid	HH	6.7
Haematopoietic and lymphoid	HL60	6.8
Haematopoietic and lymphoid	HPBALL	7
Haematopoietic and lymphoid	HS604T	6.8
Haematopoietic and lymphoid	HS611T	6.5
Haematopoietic and lymphoid	HS616T	6.6
Haematopoietic and lymphoid	HS751T	6.1
Haematopoietic and lymphoid	HT	6.4
Haematopoietic and lymphoid	HTK	6.7
Haematopoietic and lymphoid	HUNS1	6.7
Haematopoietic and lymphoid	HUT102	6.7
Haematopoietic and lymphoid	HUT78	6.6
Haematopoietic and lymphoid	JEKO1	7.1
Haematopoietic and lymphoid	JK1	7.6
Haematopoietic and lymphoid	JM1	6.3
Haematopoietic and lymphoid	JURKAT	6.8
Haematopoietic and lymphoid	JURLMK1	6.7
Haematopoietic and lymphoid	JVM2	7.1
Haematopoietic and lymphoid	JVM3	6.8
Haematopoietic and lymphoid	K562	7.2
Haematopoietic and lymphoid	KARPAS299	6.9
Haematopoietic and lymphoid	KARPAS422	7.2
Haematopoietic and lymphoid	KARPAS620	7.1
Haematopoietic and lymphoid	KASUMI1	6.3
Haematopoietic and lymphoid	KASUMI2	7
Haematopoietic and lymphoid	KASUMI6	7.1
Haematopoietic and lymphoid	KCL22	6.9
Haematopoietic and lymphoid	KE37	6.6
Haematopoietic and lymphoid	KE97	6.7
Haematopoietic and lymphoid	KG1	7
Haematopoietic and lymphoid	KHM1B	7.3
Haematopoietic and lymphoid	KIJK	6.5
Haematopoietic and lymphoid	KMH2	7.1
Haematopoietic and lymphoid	KMM1	6.9
Haematopoietic and lymphoid	KMS11	6.6
Haematopoietic and lymphoid	KMS12BM	7.1
Haematopoietic and lymphoid	KMS18	6.6
Haematopoietic and lymphoid	KMS20	7.4
Haematopoietic and lymphoid	KMS21BM	7.1
Haematopoietic and lymphoid	KMS26	6.4
Haematopoietic and lymphoid	KMS27	7
Haematopoietic and lymphoid	KMS28BM	7.1
Haematopoietic and lymphoid	KMS34	6.7
Haematopoietic and lymphoid	KO52	6.6
Haematopoietic and lymphoid	KOPN8	7.1
Haematopoietic and lymphoid	KU812	7.4
Haematopoietic and lymphoid	KYO1	7.7
Haematopoietic and lymphoid	L1236	6.4
Haematopoietic and lymphoid	L363	7.1
Haematopoietic and lymphoid	L428	6.7
Haematopoietic and lymphoid	L540	7
Haematopoietic and lymphoid	LAMA84	6.6
Haematopoietic and lymphoid	LOUCY	6.4
Haematopoietic and lymphoid	LP1	8
Haematopoietic and lymphoid	M07E	7.4
Haematopoietic and lymphoid	MC116	6.9
Haematopoietic and lymphoid	ME1	7.1
Haematopoietic and lymphoid	MEC1	7
Haematopoietic and lymphoid	MEC2	6.7
Haematopoietic and lymphoid	MEG01	6.7
Haematopoietic and lymphoid	MHHCALL2	6.8
Haematopoietic and lymphoid	MHHCALL3	6.5
Haematopoietic and lymphoid	MHHCALL4	6.9
Haematopoietic and lymphoid	MINO	6.7
Haematopoietic and lymphoid	MJ	6.6
Haematopoietic and lymphoid	MM1S	6.5
Haematopoietic and lymphoid	MOLM13	6.7
Haematopoietic and lymphoid	MOLM16	6.7
Haematopoietic and lymphoid	MOLM6	6.7
Haematopoietic and lymphoid	MOLP2	7.8
Haematopoietic and lymphoid	MOLP8	6.8
Haematopoietic and lymphoid	MOLT13	6.9
Haematopoietic and lymphoid	MOLT16	6.6
Haematopoietic and lymphoid	MOLT4	6.1
Haematopoietic and lymphoid	MONOMAC1	6.6
Haematopoietic and lymphoid	MONOMAC6	6.8
Haematopoietic and lymphoid	MOTN1	6.4
Haematopoietic and lymphoid	MUTZ5	7.3
Haematopoietic and lymphoid	MV411	6.9
Haematopoietic and lymphoid	NALM19	7
Haematopoietic and lymphoid	NALM1	7
Haematopoietic and lymphoid	NALM6	7.1
Haematopoietic and lymphoid	NAMALWA	7.2
Haematopoietic and lymphoid	NB4	6.5
Haematopoietic and lymphoid	NCIH929	7.2
Haematopoietic and lymphoid	NCO2	6.6
Haematopoietic and lymphoid	NOMO1	6.8
Haematopoietic and lymphoid	NUDHL1	7.2
Haematopoietic and lymphoid	NUDUL1	7.1
Haematopoietic and lymphoid	OCIAML2	6.3
Haematopoietic and lymphoid	OCIAML3	6.7
Haematopoietic and lymphoid	OCIAML5	6.5
Haematopoietic and lymphoid	OCILY10	7
Haematopoietic and lymphoid	OCILY19	6.6
Haematopoietic and lymphoid	OCILY3	6.5
Haematopoietic and lymphoid	OCIM1	7.7
Haematopoietic and lymphoid	OPM2	7
Haematopoietic and lymphoid	P12ICHIKAWA	7.2
Haematopoietic and lymphoid	P31FUJ	6.6
Haematopoietic and lymphoid	P3HR1	6.7
Haematopoietic and lymphoid	PCM6	6.9
Haematopoietic and lymphoid	PEER	7
Haematopoietic and lymphoid	PF382	6.6
Haematopoietic and lymphoid	PFEIFFER	6.6
Haematopoietic and lymphoid	PL21	6.5
Haematopoietic and lymphoid	RAJI	6.8
Haematopoietic and lymphoid	RCHACV	6.3
Haematopoietic and lymphoid	REC1	6.6
Haematopoietic and lymphoid	REH	7.1
Haematopoietic and lymphoid	RI1	6.7
Haematopoietic and lymphoid	RL	6.7
Haematopoietic and lymphoid	RPMI8226	6.7
Haematopoietic and lymphoid	RPMI8402	7.5
Haematopoietic and lymphoid	RS411	6.9
Haematopoietic and lymphoid	SEM	6.9
Haematopoietic and lymphoid	SET2	7.2
Haematopoietic and lymphoid	SIGM5	6.2
Haematopoietic and lymphoid	SKM1	6.3
Haematopoietic and lymphoid	SKMM2	7.2
Haematopoietic and lymphoid	SR786	7.1
Haematopoietic and lymphoid	ST486	7
Haematopoietic and lymphoid	SUDHL10	7.4
Haematopoietic and lymphoid	SUDHL1	6.6
Haematopoietic and lymphoid	SUDHL4	6.5
Haematopoietic and lymphoid	SUDHL5	6.8
Haematopoietic and lymphoid	SUDHL6	6.7
Haematopoietic and lymphoid	SUDHL8	6.9
Haematopoietic and lymphoid	SUPB15	6.4
Haematopoietic and lymphoid	SUPHD1	7.5
Haematopoietic and lymphoid	SUPM2	6.5
Haematopoietic and lymphoid	SUPT11	6.6
Haematopoietic and lymphoid	SUPT1	6.6
Haematopoietic and lymphoid	TALL1	6.9
Haematopoietic and lymphoid	TF1	6.8
Haematopoietic and lymphoid	THP1	6.4
Haematopoietic and lymphoid	TO175T	6.7
Haematopoietic and lymphoid	TOLEDO	7.1
Haematopoietic and lymphoid	U266B1	7
Haematopoietic and lymphoid	U937	6.7
Haematopoietic and lymphoid	UT7	7
Haematopoietic and lymphoid	WSUDLCL2	7.3
Kidney	769P	6.3
Kidney	786O	6.2
Kidney	A498	7
Kidney	A704	7.2
Kidney	ACHN	6.7
Kidney	BFTC909	6.2
Kidney	CAKI1	6.8
Kidney	CAKI2	6.9
Kidney	CAL54	6.9
Kidney	KMRC1	6.3
Kidney	KMRC20	6.5
Kidney	KMRC2	6.5
Kidney	KMRC3	6.8
Kidney	OSRC2	6.7
Kidney	RCC10RGB	6.5
Kidney	SNU1272	7.2
Kidney	SNU349	6.7
Kidney	TUHR10TKB	7.1
Kidney	TUHR14TKB	6.9
Kidney	TUHR4TKB	6.4
Kidney	VMRCRCW	6.5
Kidney	VMRCRCZ	6.7
Large intestine	C2BBE1	6.8
Large intestine	CCK81	7
Large intestine	CL11	6.5
Large intestine	CL14	7.1
Large intestine	CL34	6.8
Large intestine	CL40	6.6
Large intestine	COLO205	6.6
Large intestine	COLO320	7.2
Large intestine	COLO678	7
Large intestine	CW2	7
Large intestine	DLD1	6.9
Large intestine	GP2D	6.8
Large intestine	HCC56	7.3
Large intestine	HCT116	6.6
Large intestine	HCT15	6.7
Large intestine	HS675T	6.5
Large intestine	HS698T	6.5
Large intestine	HT115	7
Large intestine	HT29	6.6
Large intestine	HT55	6.7
Large intestine	KM12	6.8
Large intestine	LOVO	6.7
Large intestine	LS1034	6.8
Large intestine	LS123	6.5
Large intestine	LS180	7
Large intestine	LS411N	6.9
Large intestine	LS513	6.4
Large intestine	MDST8	6.6
Large intestine	NCIH508	7.2
Large intestine	NCIH716	6.5
Large intestine	NCIH747	6.8
Large intestine	OUMS23	6.7
Large intestine	RCM1	6.8
Large intestine	RKO	6.7
Large intestine	SKCO1	6.3
Large intestine	SNU1040	7
Large intestine	SNU1197	6.1
Large intestine	SNU175	7.3
Large intestine	SNU283	7
Large intestine	SNU407	7.5
Large intestine	SNU503	6.2
Large intestine	SNU61	6.8
Large intestine	SNU81	7.2
Large intestine	SNUC1	6.8
Large intestine	SNUC2A	6.9
Large intestine	SNUC4	6.8
Large intestine	SNUC5	6.6
Large intestine	SW1116	7.1
Large intestine	SW1417	6.7
Large intestine	SW1463	6.8
Large intestine	SW403	6.9
Large intestine	SW480	6.6
Large intestine	SW48	7
Large intestine	SW620	7.1
Large intestine	SW837	5.8
Large intestine	SW948	6.9
Large intestine	T84	7.1
Liver	ALEXANDERCELLS	6.9
Liver	C3A	6.8
Liver	HEP3B217	6.9
Liver	HEPG2	6.9
Liver	HLE	6.7
Liver	HLF	6.6
Liver	HUH1	6.2
Liver	HUH6	6.7
Liver	HUH7	6.3
Liver	JHH1	7.4
Liver	JHH2	7
Liver	JHH4	7.1
Liver	JHH5	6.3
Liver	JHH6	6.6
Liver	JHH7	6.9
Liver	LI7	6.6
Liver	PLCPRF5	7
Liver	SKHEP1	6.2
Liver	SNU182	6.5
Liver	SNU387	6.7
Liver	SNU398	6.9
Liver	SNU423	6.5
Liver	SNU449	7
Liver	SNU475	6.3
Liver	SNU761	6.9
Liver	SNU878	6.3
Liver	SNU886	6.2
Lung	A549	6.8
Lung	ABC1	6.6
Lung	BEN	7.1
Lung	CAL12T	6.6
Lung	CALU1	6.9
Lung	CALU3	6.6
Lung	CALU6	6.3
Lung	CHAGOK1	6.5
Lung	COLO668	6.2
Lung	COLO699	6.6
Lung	CORL105	7.3
Lung	CORL23	6.9
Lung	CORL24	6.2
Lung	CORL279	6.5
Lung	CORL311	7.2
Lung	CORL47	6.6
Lung	CORL51	6
Lung	CORL88	6.1
Lung	CORL95	6.6
Lung	CPCN	6.5
Lung	DMS114	6.7
Lung	DMS153	6.8
Lung	DMS273	6.3
Lung	DMS454	6.8
Lung	DMS53	6.8
Lung	DMS79	6.5
Lung	DV90	6.6
Lung	EBC1	6.2
Lung	EPLC272H	6.6
Lung	HARA	6.7
Lung	HCC1171	6.8
Lung	HCC1195	6.8
Lung	HCC15	6.8
Lung	HCC2279	6.3
Lung	HCC2935	7.3
Lung	HCC33	6.7
Lung	HCC366	6.4
Lung	HCC4006	6.5
Lung	HCC44	6.3
Lung	HCC78	6.9
Lung	HCC827	6.5
Lung	HCC95	6.4
Lung	HLC1	7.5
Lung	HLFA	6.3
Lung	HS229T	6.2
Lung	HS618T	6.1
Lung	IALM	7
Lung	KNS62	6.8
Lung	LC1F	6.6
Lung	LC1SQSF	6.1
Lung	LCLC103H	6.8
Lung	LCLC97TM1	6.7
Lung	LK2	6.5
Lung	LOUNH91	6.9
Lung	LU65	6.8
Lung	LU99	6
Lung	LUDLU1	6.4
Lung	LXF289	6.8
Lung	MORCPR	6.8
Lung	NCIH1048	6.7
Lung	NCIH1092	6.1
Lung	NCIH1105	6.7
Lung	NCIH1155	6.6
Lung	NCIH1184	6.7
Lung	NCIH1299	6.6
Lung	NCIH1339	6.6
Lung	NCIH1341	6.6
Lung	NCIH1355	6.2
Lung	NCIH1373	6.9
Lung	NCIH1385	6.7
Lung	NCIH1395	7.1
Lung	NCIH1435	6.9
Lung	NCIH1436	6.4
Lung	NCIH1437	6.4
Lung	NCIH146	6.8
Lung	NCIH1563	6.9
Lung	NCIH1568	6.6
Lung	NCIH1573	6.6
Lung	NCIH1581	7.7
Lung	NCIH1618	6.6
Lung	NCIH1623	6.7
Lung	NCIH1648	6.4
Lung	NCIH1650	6.1
Lung	NCIH1651	7.5
Lung	NCIH1666	6.6
Lung	NCIH1693	6.3
Lung	NCIH1694	6.8
Lung	NCIH1703	6.4
Lung	NCIH1734	6.4
Lung	NCIH1755	6.4
Lung	NCIH1781	6.8
Lung	NCIH1792	6.4
Lung	NCIH1793	6.6
Lung	NCIH1836	6.7
Lung	NCIH1838	6.9
Lung	NCIH1869	6.3
Lung	NCIH1876	6.2
Lung	NCIH1915	7.3
Lung	NCIH1930	6.9
Lung	NCIH1944	6.6
Lung	NCIH1963	6.4
Lung	NCIH196	6.7
Lung	NCIH1975	6.8
Lung	NCIH2009	6.4
Lung	NCIH2023	6.4
Lung	NCIH2029	7.1
Lung	NCIH2030	6.2
Lung	NCIH2066	6.5
Lung	NCIH2081	6.4
Lung	NCIH2085	6.9
Lung	NCIH2087	6.4
Lung	NCIH209	6.8
Lung	NCIH2106	7.3
Lung	NCIH2110	6.5
Lung	NCIH211	6.9
Lung	NCIH2122	6.7
Lung	NCIH2126	7.3
Lung	NCIH2141	6.4
Lung	NCIH2170	6.7
Lung	NCIH2171	6.6
Lung	NCIH2172	6.4
Lung	NCIH2196	7.2
Lung	NCIH2227	8
Lung	NCIH2228	6.4
Lung	NCIH226	6.5
Lung	NCIH2286	6.5
Lung	NCIH2291	6.6
Lung	NCIH2342	6.6
Lung	NCIH2347	6.5
Lung	NCIH23	6.6
Lung	NCIH2405	6.9
Lung	NCIH2444	6.5
Lung	NCIH292	7.1
Lung	NCIH322	6.1
Lung	NCIH3255	7
Lung	NCIH358	6.2
Lung	NCIH441	6.8
Lung	NCIH446	6.9
Lung	NCIH460	6.6
Lung	NCIH510	6.3
Lung	NCIH520	6.4
Lung	NCIH522	7.7
Lung	NCIH524	6.7
Lung	NCIH526	6.9
Lung	NCIH596	6.5
Lung	NCIH647	6.4
Lung	NCIH650	6.5
Lung	NCIH661	6.7
Lung	NCIH69	6.6
Lung	NCIH727	6.2
Lung	NCIH810	6.6
Lung	NCIH82	6.3
Lung	NCIH838	6.5
Lung	NCIH841	7.4
Lung	NCIH854	6.5
Lung	NCIH889	7
Lung	PC14	6.6
Lung	RERFLCAD1	6.5
Lung	RERFLCAD2	7
Lung	RERFLCAI	6.9
Lung	RERFLCKJ	7.1
Lung	RERFLCMS	6.5
Lung	RERFLCSQ1	6.2
Lung	SBC5	7.6
Lung	SCLC21H	6.7
Lung	SHP77	6.4
Lung	SKLU1	6.5
Lung	SKMES1	7
Lung	SQ1	6.5
Lung	SW1271	6.6
Lung	SW1573	6.7
Lung	SW900	6.3
Lung	VMRCLCD	7
Lung	VMRCLCP	6.2
Oesophagus	COLO680N	7.5
Oesophagus	ECGI10	7
Oesophagus	KYSE140	6.6
Oesophagus	KYSE150	6.9
Oesophagus	KYSE180	6.8
Oesophagus	KYSE270	6.8
Oesophagus	KYSE30	7.2
Oesophagus	KYSE410	6.5
Oesophagus	KYSE450	7.2
Oesophagus	KYSE510	6.7
Oesophagus	KYSE520	6.6
Oesophagus	KYSE70	7.2
Oesophagus	OE19	7.2
Oesophagus	OE33	6.5
Oesophagus	TE10	6.7
Oesophagus	TE11	6.7
Oesophagus	TE14	6.9
Oesophagus	TE15	6.4
Oesophagus	TE1	6.1
Oesophagus	TE4	6.5
Oesophagus	TE5	7.2
Oesophagus	TE6	7.1
Oesophagus	TE8	6.6
Oesophagus	TE9	6.8
Oesophagus	TT	7.2
Ovary	59M	6.3
Ovary	A2780	7.1
Ovary	CAOV3	6.3
Ovary	CAOV4	6.6
Ovary	COLO704	6.5
Ovary	COV318	6.3
Ovary	COV362	5.9
Ovary	COV434	6.6
Ovary	COV504	6.4
Ovary	COV644	6.7
Ovary	EFO21	6.7
Ovary	EFO27	7.2
Ovary	ES2	6.3
Ovary	FUOV1	6.6
Ovary	HEYA8	6.2
Ovary	HS571T	6.8
Ovary	IGROV1	6.7
Ovary	JHOC5	6.4
Ovary	JHOM1	6.8
Ovary	JHOM2B	6.3
Ovary	JHOS2	6.7
Ovary	JHOS4	6.5
Ovary	KURAMOCHI	6.4
Ovary	MCAS	6.9
Ovary	NIHOVCAR3	6.8
Ovary	OAW28	6.5
Ovary	OAW42	6.8
Ovary	OC314	7
Ovary	OC316	7
Ovary	ONCODG1	7
Ovary	OV56	5.9
Ovary	OV7	6.5
Ovary	OV90	6.4
Ovary	OVCAR4	6.4
Ovary	OVCAR8	5.9
Ovary	OVISE	6.7
Ovary	OVK18	7.3
Ovary	OVKATE	6.5
Ovary	OVMANA	6.6
Ovary	OVSAHO	6.8
Ovary	OVTOKO	6.9
Ovary	RMGI	6.8
Ovary	RMUGS	7.2
Ovary	SKOV3	6.9
Ovary	SNU119	6.2
Ovary	SNU840	7
Ovary	SNU8	6.5
Ovary	TOV112D	7.1
Ovary	TOV21G	7
Ovary	TYKNU	6.7
Pancreas	ASPC1	7.1
Pancreas	BXPC3	6.3
Pancreas	CAPAN1	6.7
Pancreas	CAPAN2	6.9
Pancreas	CFPAC1	6.4
Pancreas	DANG	6.7
Pancreas	HPAC	6.8
Pancreas	HPAFII	6.6
Pancreas	HS766T	6.5
Pancreas	HUPT3	6.6
Pancreas	HUPT4	6.6
Pancreas	KCIMOH1	6.5
Pancreas	KLM1	6.5
Pancreas	KP2	7
Pancreas	KP3	7
Pancreas	KP4	7
Pancreas	L33	6.9
Pancreas	MIAPACA2	6.8
Pancreas	PANC0203	6.4
Pancreas	PANC0213	6.7
Pancreas	PANC0327	6.2
Pancreas	PANC0403	6.5
Pancreas	PANC0504	6.5
Pancreas	PANC0813	6.5
Pancreas	PANC1005	6.4
Pancreas	PANC1	7.2
Pancreas	PATU8902	6.5
Pancreas	PATU8988S	7.1
Pancreas	PATU8988T	7.2
Pancreas	PK1	6.3
Pancreas	PK45H	6.5
Pancreas	PK59	6.9
Pancreas	PL45	6.3
Pancreas	PSN1	6.6
Pancreas	QGP1	6.8
Pancreas	SNU213	6.4
Pancreas	SNU324	7.2
Pancreas	SNU410	6.5
Pancreas	SU8686	6.9
Pancreas	SUIT2	6.3
Pancreas	SW1990	6.2
Pancreas	T3M4	6.7
Pancreas	TCCPAN2	6.8
Pancreas	YAPC	6.7
Pleura	ACCMESO1	6.4
Pleura	DM3	6.6
Pleura	ISTMES1	6.4
Pleura	ISTMES2	6.5
Pleura	JL1	6.6
Pleura	MPP89	6.2
Pleura	MSTO211H	6.5
Pleura	NCIH2052	6.5
Pleura	NCIH2452	6.8
Pleura	NCIH28	6.7
Prostate	22RV1	7.2
Prostate	DU145	6.3
Prostate	LNCAPCLONEFGC	7.6
Prostate	MDAPCA2B	7
Prostate	NCIH660	6.8
Prostate	PC3	7
Prostate	VCAP	6.7
Salivary gland	A253	6.5
Salivary gland	YD15	6.7
Skin	A101D	6.1
Skin	A2058	6.7
Skin	A375	6.6
Skin	C32	6.2
Skin	CHL1	6.5
Skin	CJM	7.5
Skin	COLO679	6.4
Skin	COLO741	6.9
Skin	COLO783	6.6
Skin	COLO792	6.3
Skin	COLO800	5.9
Skin	COLO818	6.1
Skin	COLO829	6.7
Skin	COLO849	6.4
Skin	G361	6.8
Skin	GRM	6.8
Skin	HMCB	6.5
Skin	HS294T	6.8
Skin	HS600T	6.5
Skin	HS688AT	6.8
Skin	HS695T	6.4
Skin	HS839T	6.5
Skin	HS852T	6.8
Skin	HS895T	6.5
Skin	HS934T	6.4
Skin	HS936T	6.3
Skin	HS939T	6.5
Skin	HS940T	6.6
Skin	HS944T	6.2
Skin	HT144	6.4
Skin	IGR1	6.4
Skin	IGR37	6.6
Skin	IGR39	6.3
Skin	IPC298	6.4
Skin	K029AX	6.3
Skin	LOXIMVI	6.8
Skin	MALME3M	6.2
Skin	MDAMB435S	5.9
Skin	MELHO	6.6
Skin	MELJUSO	6.4
Skin	MEWO	6.5
Skin	RPMI7951	6
Skin	RVH421	6.5
Skin	SH4	6.5
Skin	SKMEL1	6.5
Skin	SKMEL24	6.6
Skin	SKMEL28	6.3
Skin	SKMEL2	6.4
Skin	SKMEL30	6.5
Skin	SKMEL31	6.4
Skin	SKMEL3	6.8
Skin	SKMEL5	6.8
Skin	UACC257	6.1
Skin	UACC62	6.4
Skin	WM115	6.6
Skin	WM1799	6
Skin	WM2664	6.7
Skin	WM793	6
Skin	WM88	6.8
Skin	WM983B	6
Small intestine	HUTU80	7
Soft tissue	A204	7.3
Soft tissue	G401	7
Soft tissue	G402	7
Soft tissue	GCT	6.8
Soft tissue	HS729	6.4
Soft tissue	HT1080	6.5
Soft tissue	KYM1	7
Soft tissue	MESSA	6.9
Soft tissue	RD	6.8
Soft tissue	RH30	7.5
Soft tissue	RH41	7.5
Soft tissue	RKN	6.7
Soft tissue	S117	6.3
Soft tissue	SJRH30	6.9
Soft tissue	SKLMS1	7
Soft tissue	SKUT1	6.9
Soft tissue	TE125T	6.7
Soft tissue	TE159T	6.7
Soft tissue	TE441T	6.9
Soft tissue	TE617T	7.2
Stomach	2313287	7
Stomach	AGS	6.7
Stomach	AZ521	7
Stomach	ECC10	6.9
Stomach	ECC12	5.6
Stomach	FU97	6.8
Stomach	GCIY	6.9
Stomach	GSS	6.1
Stomach	GSU	7
Stomach	HGC27	6.8
Stomach	HS746T	6.8
Stomach	HUG1N	5.8
Stomach	IM95	7.2
Stomach	KATOIII	6.5
Stomach	KE39	6.8
Stomach	LMSU	7.7
Stomach	MKN1	6.7
Stomach	MKN45	6.4
Stomach	MKN74	6.8
Stomach	MKN7	7.6
Stomach	NCCSTCK140	7.2
Stomach	NCIN87	6.3
Stomach	NUGC2	7.3
Stomach	NUGC3	7
Stomach	NUGC4	6.8
Stomach	OCUM1	6.7
Stomach	RERFGC1B	7.1
Stomach	SH10TC	6.7
Stomach	SNU16	6.5
Stomach	SNU1	6.6
Stomach	SNU216	7.3
Stomach	SNU520	6.4
Stomach	SNU5	7.1
Stomach	SNU601	6.8
Stomach	SNU620	6.7
Stomach	SNU668	7.2
Stomach	SNU719	6.8
Stomach	TGBC11TKB	7
Thyroid	8305C	6.6
Thyroid	8505C	6.6
Thyroid	BCPAP	7.2
Thyroid	BHT101	6.4
Thyroid	CAL62	6.8
Thyroid	CGTHW1	6.6
Thyroid	FTC133	6.6
Thyroid	FTC238	6.3
Thyroid	ML1	6.5
Thyroid	SW579	6.6
Thyroid	TT2609C02	6.6
Thyroid	TT	7
Upper aerodigestive tract	BHY	7.8
Upper aerodigestive tract	BICR16	7
Upper aerodigestive tract	BICR18	7.2
Upper aerodigestive tract	BICR22	6.8
Upper aerodigestive tract	BICR31	6.6
Upper aerodigestive tract	BICR56	6.5
Upper aerodigestive tract	BICR6	6.7
Upper aerodigestive tract	CAL27	6.9
Upper aerodigestive tract	CAL33	7
Upper aerodigestive tract	DETROIT562	6.3
Upper aerodigestive tract	FADU	6.6
Upper aerodigestive tract	HS840T	6.2
Upper aerodigestive tract	HSC2	6.7
Upper aerodigestive tract	HSC3	6.6
Upper aerodigestive tract	HSC4	6.9
Upper aerodigestive tract	PECAPJ15	6.8
Upper aerodigestive tract	PECAPJ34CLONEC12	6.3
Upper aerodigestive tract	PECAPJ41CLONED2	6.7
Upper aerodigestive tract	PECAPJ49	6.5
Upper aerodigestive tract	SCC15	6.8
Upper aerodigestive tract	SCC25	6.8
Upper aerodigestive tract	SCC4	6.4
Upper aerodigestive tract	SCC9	7.4
Upper aerodigestive tract	SNU1076	7
Upper aerodigestive tract	SNU1214	6.5
Upper aerodigestive tract	SNU46	6.9
Upper aerodigestive tract	SNU899	6.8
Upper aerodigestive tract	YD10B	7.5
Upper aerodigestive tract	YD38	6.6
Upper aerodigestive tract	YD8	7.2
Urinary tract	5637	6.3
Urinary tract	639V	6.5
Urinary tract	647V	6.8
Urinary tract	BC3C	6.7
Urinary tract	BFTC905	6.6
Urinary tract	CAL29	6.2
Urinary tract	HS172T	6.6
Urinary tract	HT1197	6.6
Urinary tract	HT1376	7.3
Urinary tract	J82	6.6
Urinary tract	JMSU1	6.4
Urinary tract	KMBC2	7.2
Urinary tract	KU1919	6.3
Urinary tract	RT11284	6
Urinary tract	RT112	6.3
Urinary tract	RT4	6
Urinary tract	SCABER	6.6
Urinary tract	SW1710	7.1
Urinary tract	SW780	6.5
Urinary tract	T24	6.7
Urinary tract	TCCSUP	6.5
Urinary tract	UMUC1	6.7
Urinary tract	UMUC3	6.1
Urinary tract	VMCUB1	6.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	11.3
Adrenal gland	13.1
Appendix	14.6
Bone marrow	7.5
Breast	25
Cerebral cortex	32.8
Cervix, uterine	11.9
Colon	12.1
Duodenum	14
Endometrium	21.4
Epididymis	49.8
Esophagus	6.9
Fallopian tube	24.1
Gallbladder	12.8
Heart muscle	11.2
Kidney	11.9
Liver	6
Lung	15.6
Lymph node	16.5
Ovary	24.1
Pancreas	2.4
Parathyroid gland	26.7
Placenta	8.8
Prostate	22.3
Rectum	16.7
Salivary gland	5.3
Seminal vesicle	18.1
Skeletal muscle	9.9
Skin	24.6
Small intestine	15.7
Smooth muscle	15.5
Spleen	19.6
Stomach	10.2
Testis	34.6
Thyroid gland	22.6
Tonsil	14.8
Urinary bladder	10.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
23475622	underexpression	Head and Neck Squamous Cell Carcinoma	Our results demonstrated that the expression levels of SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, and SIRT7 were significantly downregulated in cancerous tissues compared with noncancerous tissues (all p<0.01).
24774224	underexpression	Hepatocellular Carcinoma	IHC and WB studies both showed a decreased expression of Sirt3 in tumoral tissues compared with peritumoral tissues (P = 0.003 for IHC, P = 0.0042 for WB).
27709558	underexpression (copy number loss)	Colorectal Carcinoma	Subsequent integrated analyses revealed that increased expression levels of the MMP9, BMP7, UBE2C, I-CAM, NOTCH3, NOTCH1, PTGES2, HMGB1 and ERBB3 genes were associated with copy number gains, whereas decreased expression levels of the MUC1, E2F2, HRAS and SIRT3 genes were associated with copy number losses.
27216459	underexpression	Ovarian Carcinoma	Here, we found that SIRT3 was significantly down-regulated in the metastatic tissues and highly metastatic cell line of ovarian cancer.
27114304	overexpression	Renal Cell Carcinoma	We show increased Sirt3 expression in the mitochondrial fraction of human RCC tissues.
26922015	underexpression	Hepatocellular Carcinoma	SIRT3 expression was significantly lower in the 3 HCC cell lines than in immortalized hepatocytes and normal liver tissues.
26785117	underexpression	Hepatocellular Carcinoma	A statistically significant downregulation of SIRT3 (p<0.001), SIRT4 (p<0.0001), MTUS1 (p<0.002) and OGG1 (p<0.0001) was observed in HNSCC compared to control samples.
26743598	overexpression	Melanoma	We found that compared with normal primary and immortalized human melanocytes, SIRT3 is significantly overexpressed in multiple human melanoma cells at mRNA and protein levels.
26631723	underexpression	B cell malignancy	Further, SIRT3 protein expression was reduced in chronic lymphocytic leukemia primary samples and malignant B cell lines compared to primary B cells from healthy donors.
26317998	underexpression	Prostate Carcinoma	We found that SIRT3 was moderately down-regulated in prostate carcinomas.
26131100	underexpression	Gastric Carcinoma	The present study revealed that the mRNA and protein levels of SIRT3 were significantly reduced in human gastric cancer tissues and cell lines.
26121691	overexpression	Gastric Carcinoma	This study demonstrated that the expression of SIRT3 was elevated in a group of gastric cancer cells compared to normal gastric epithelial cells. Although SIRT3 expression levels were increased in the gastric tumor tissues compared to the adjacent non-tumor tissues, SIRT3 positive cancer cells were more frequently detected in the intestinal type gastric cancers than the diffuse type gastric cancers, indicating that SIRT3 is linked with subtypes of gastric cancer.
25915842	underexpression	Hepatocellular Carcinoma	In this study, we found that SIRT3 expression was frequently repressed in HCC and its downregulation was closely associated with tumor grade and size.
25755250	underexpression	Pancreatic Neoplasm	Finally, we show that GOT2K159 acetylation is increased in human pancreatic tumors, which correlates with reduced SIRT3 expression.
25005846	overexpression	Esophageal Squamous Cell Carcinoma	High expression of SIRT3 in ESCC tissues was more frequently observed than corresponding adjacent non-malignant esophageal mucosa tissues.
24955214	underexpression	Breast Carcinoma	Recently, SIRT3 was reported to be decreased in 87% of breast cancers, resulting therefore in a decrease in the activity of SOD2 and an elevation in ROS.
24746213	underexpression	Breast Neoplasm	SIRT3 protein expression is significantly lower in neoplastic compared with normal breast epithelium, including normal epithelium adjacent to tumors.
24448804	underexpression	Breast Carcinoma	Recent studies indicated that SIRT3 is decreased in 87% of breast cancers, implying that the activity of SOD2 is compromised.
24287180	underexpression	Gastric Carcinoma	Western blot analysis of 25 samples from GC patients showed that 64% (16/25) of patients exhibited decreased expression of SIRT3, whereas 4.0% (1/25) of patients displayed complete loss.
23898059	overexpression	Thyroid Gland Papillary Carcinoma	NAMPT and SIRT3 expression was low in benign thyroid tissues, moderately increased in FC, and more highly expressed in PTC.
23842789	underexpression	Lung Adenocarcinoma	In the present study, we found that Sirt3 protein expression was downregulated in human lung adenocarcinoma tissue when compared with that in adjacent normal tissue.
23790338	underexpression	Hepatocellular Carcinoma	Immunohistochemical assay showed that the SIRT3 positive expression rates were 100.0% (10/10), 96.7% (29/30) and 60.0% (18/30), respectively in normal group, paracancer group and HCC group.
23562596	overexpression	Breast Carcinoma; Oral Cavity Squamous Cell Carcinoma	Increased SIRT3 transcription has been associated with node-positive breast cancer and oral squamous cell carcinoma.
23272146	underexpression	Hepatocellular Carcinoma	In this study, we demonstrated that SIRT3 expression in HCC tissue was much lower than that in paracarcinoma tissue, at both mRNA and protein levels.
22609775	underexpression	Hepatocellular Carcinoma	In this study, we found that Sirt3 protein expression was downregulated in human HCC tissue.
21472714	overexpression	Oral Cavity Squamous Cell Carcinoma	The expression levels of all sirtuins in several oral squamous cell carcinoma (OSCC) cell lines were compared with normal human oral keratinocytes and observed that SIRT3 was highly expressed.
21397863	underexpression	Breast Carcinoma	SIRT3 expression is reduced in human breast cancers, and its loss correlates with the upregulation of HIF1α target genes.
20129246	underexpression	Breast Carcinoma	Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels.
27080717	overexpression	Breast Carcinoma	In contrast, SIRT2, SIRT3, and SIRT5 genes were shown to be up-regulated in our study.
28560068	Underexpression; Mutation	Breast Carcinoma	We demonstrated that HDAC2 and SIRT7 were the most commonly amplified/overexpressed, and SIRT3 was most deleted/underexpressed, particularly in aggressive basal-like breast cancer.
28347248	Underexpression	Hepatocellular Carcinoma	The results demonstrated that the expression levels of SIRT3 protein in hepatocellular carcinoma tissues were significantly downregulated compared with those in adjacent non-cancerous tissues.
28197634	Overexpression	Non-Small Cell Lung Carcinoma	Levels of SIRT3 protein and mRNA were significantly increased in NSCLC tissue, compared with normal tissue (P<0.05).
27420645	Overexpression	Breast Carcinoma	Finally, survival curves showed that higher SIRT3 expression is correlated to a poorer prognosis for patients with grade 3 breast cancer.

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.529	1.84e-30	52	41.8	6.2	Loss
BRCA	Breast invasive carcinoma	1075	0.539	4.18e-82	28.7	58.1	13.2	Neutral
CESC	Cervical and endocervical cancers	292	0.524	5.81e-22	35.6	59.2	5.1	Loss
COAD	Colon adenocarcinoma	449	0.445	3.03e-23	13.4	73.5	13.1	Neutral
ESCA	Esophageal carcinoma	183	0.499	6.58e-13	42.1	44.3	13.7	Loss
GBM	Glioblastoma multiforme	147	0.701	4.56e-23	23.1	71.4	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.461	2e-28	31.3	56	12.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.211	1.09e-06	3.4	89.9	6.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.342	2.57e-09	5.9	90.3	3.8	Neutral
LAML	Acute Myeloid Leukemia	166	0.211	0.00642	1.8	95.8	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.689	2.29e-73	20.5	74.1	5.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.372	2.27e-13	16.8	72.3	11	Neutral
LUAD	Lung adenocarcinoma	512	0.475	3.17e-30	27.1	57.8	15	Neutral
LUSC	Lung squamous cell carcinoma	498	0.591	3.48e-48	48.6	41.6	9.8	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.681	3.53e-42	57	33	10	Loss
PAAD	Pancreatic adenocarcinoma	177	0.282	0.000146	15.3	77.4	7.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.667	3.36e-22	35.2	61.1	3.7	Loss
PRAD	Prostate adenocarcinoma	491	0.231	2.23e-07	4.7	90	5.3	Neutral
READ	Rectum adenocarcinoma	164	0.339	8.78e-06	15.2	64.6	20.1	Neutral
SARC	Sarcoma	255	0.584	1.01e-24	43.1	48.6	8.2	Loss
SKCM	Skin Cutaneous Melanoma	367	0.544	1.12e-29	30.2	57.8	12	Neutral
STAD	Stomach adenocarcinoma	413	0.386	4.4e-16	19.6	66.8	13.6	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.474	8.88e-10	62.7	30	7.3	Loss
THCA	Thyroid carcinoma	497	0.156	0.000477	1.8	97	1.2	Neutral
THYM	Thymoma	119	-0.022	0.816	8.4	90.8	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.372	4.51e-19	19.6	73.4	7.1	Neutral

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.332	2.67e-12	17	408	0	0.369	NS/NA
BRCA	Breast invasive carcinoma	-0.209	5.7e-10	83	785	-0.001	0.142	NS/NA
CESC	Cervical and endocervical cancers	-0.267	2.13e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.214	0.000135	19	297	0.001	0.0521	NS/NA
ESCA	Esophageal carcinoma	-0.193	0.00702	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.303	0.0146	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.114	0.00811	20	522	0.005	5.85e-07	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.167	0.00199	24	319	0.033	1.26e-11	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.009	0.884	23	275	-0.002	0.98	NS/NA
LAML	Acute Myeloid Leukemia	-0.101	0.19	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.295	5.07e-12	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.185	0.000156	41	373	-0.001	0.609	NS/NA
LUAD	Lung adenocarcinoma	-0.088	0.0553	21	456	0.001	0.36	NS/NA
LUSC	Lung squamous cell carcinoma	-0.177	0.00054	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.6	0.0968	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.206	0.00521	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.488	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.142	0.000996	35	498	-0.005	0.189	NS/NA
READ	Rectum adenocarcinoma	-0.148	0.139	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.333	3.71e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.238	1.93e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.173	0.000812	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.33	2.88e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.063	0.138	50	509	0	0.164	NS/NA
THYM	Thymoma	-0.147	0.106	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.228	7.42e-07	34	431	-0.001	0.364	NS/NA

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	2	Medium
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	2	Medium
Prostate	3	High
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.494	NS	24476821
BRCA	Breast invasive carcinoma	521	1.41e-22	Significant	23000897
COAD	Colon adenocarcinoma	149	0.452	NS	22810696
GBM	Glioblastoma multiforme	157	3.18e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.17e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	3.72e-05	Significant	26536169
LGG	Brain Lower Grade Glioma	513	5.02e-12	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00305	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.71e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0361	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000369	Significant	26544944
READ	Rectum adenocarcinoma	67	0.148	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.184	NS	26091043
STAD	Stomach adenocarcinoma	277	2.69e-05	Significant	25079317
THCA	Thyroid carcinoma	391	0.259	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0308	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.766	0.213	NS
BRCA	Breast invasive carcinoma	1079	0.859	0.51	NS
CESC	Cervical and endocervical cancers	291	0.734	0.389	NS
COAD	Colon adenocarcinoma	439	1.111	0.71	NS
ESCA	Esophageal carcinoma	184	0.888	0.701	NS
GBM	Glioblastoma multiforme	158	1.308	0.286	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.254	0.242	NS
KIRC	Kidney renal clear cell carcinoma	531	1.006	0.976	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.212	0.000687	Longer
LAML	Acute Myeloid Leukemia	149	0.732	0.286	NS
LGG	Brain Lower Grade Glioma	511	0.411	0.000455	Longer
LIHC	Liver hepatocellular carcinoma	365	0.913	0.704	NS
LUAD	Lung adenocarcinoma	502	0.992	0.969	NS
LUSC	Lung squamous cell carcinoma	494	0.971	0.881	NS
OV	Ovarian serous cystadenocarcinoma	303	0.992	0.964	NS
PAAD	Pancreatic adenocarcinoma	177	0.613	0.0913	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.11	0.533	NS
PRAD	Prostate adenocarcinoma	497	0	0.328	NS
READ	Rectum adenocarcinoma	159	1.144	0.792	NS
SARC	Sarcoma	259	0.71	0.262	NS
SKCM	Skin Cutaneous Melanoma	459	1.01	0.959	NS
STAD	Stomach adenocarcinoma	388	1.156	0.52	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.277	NS
THCA	Thyroid carcinoma	500	0.814	0.759	NS
THYM	Thymoma	119	2349918106.886	0.0425	Shorter
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.404	0.00459	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.065	0.192	NS
BRCA	Breast invasive carcinoma	1071	-0.043	0.162	NS
CESC	Cervical and endocervical cancers	167	-0.02	0.797	NS
COAD	Colon adenocarcinoma	445	-0.043	0.362	NS
ESCA	Esophageal carcinoma	162	-0.046	0.561	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.016	0.741	NS
KIRC	Kidney renal clear cell carcinoma	531	0.009	0.833	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.221	0.000326	Lower
LIHC	Liver hepatocellular carcinoma	347	-0.129	0.0163	Lower
LUAD	Lung adenocarcinoma	507	-0.048	0.277	NS
LUSC	Lung squamous cell carcinoma	497	0.007	0.872	NS
OV	Ovarian serous cystadenocarcinoma	302	0.019	0.74	NS
PAAD	Pancreatic adenocarcinoma	176	-0.143	0.0578	NS
READ	Rectum adenocarcinoma	156	-0.067	0.408	NS
SKCM	Skin Cutaneous Melanoma	410	-0.055	0.264	NS
STAD	Stomach adenocarcinoma	392	-0.032	0.532	NS
TGCT	Testicular Germ Cell Tumors	81	0.07	0.536	NS
THCA	Thyroid carcinoma	499	0.061	0.175	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.051	0.251	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.041	0.497	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.079	0.0772	NS
KIRC	Kidney renal clear cell carcinoma	525	0.05	0.249	NS
LGG	Brain Lower Grade Glioma	514	-0.196	7.6e-06	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.101	0.0537	NS
OV	Ovarian serous cystadenocarcinoma	296	0.077	0.185	NS
PAAD	Pancreatic adenocarcinoma	176	-0.076	0.314	NS
STAD	Stomach adenocarcinoma	406	-0.075	0.134	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.168	9.77e-05	Lower

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB02059	Adenosine-5-Diphosphoribose	Small Molecule Drug

Summary
Symbol	SIRT3
Name	sirtuin 3
Aliases	SIR2L3; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; sirtuin (silent mati ......
Location	11p15.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for SIRT3.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26785117	Hepatocellular Carcinoma	partner	SIRT4; MTUS1; OGG1-2a	positive correlation	Additionally, to explore gene-gene relationship, we observed a positive spearmen correlation between SIRT3 versus SIRT4 (r = 0.523*, p<0.0001), SIRT3 versus MTUS1 (r = 0.273, p<0.001), SIRT3 versus OGG1-2a (r = 0.213, p<0.03), SIRT4 versus OGG1 (r = 0.338**, p<0.0001) and MTUS1 versus OGG1-2a (r = 0.215, p<0.03) in HNSCC cases.
26317998	Prostate Carcinoma	downstream	Akt; c-MYC	regulation; negative regulation	Notably, upregulation of SIRT3 suppressed the phosphorylation of Akt, leading to the ubiquitination and degradation of oncoprotein c-MYC; this could be attenuated by constitutive activation of PI3K/Akt signaling.
26121691	Gastric Carcinoma	downstream	LDHA	positive regulation	Further analysis revealed that SIRT3 interacted with and deacetylated the lactate dehydrogenase A (LDHA), a key protein in regulating anaerobic glycolysis, enhancing LDHA activity.
25915842	Hepatocellular Carcinoma	downstream	GSK-3β; Bax	positive regulation	Mechanistic studies revealed that SIRT3 deacetylated and activated glycogen synthase kinase-3β (GSK-3β), which subsequently induced expression and mitochondrial translocation of the pro-apoptotic protein BCL2-associated X protein (Bax) to promote apoptosis.
25755250	Pancreatic Neoplasm	partner	GOT2	correlation	Finally, we show that GOT2K159 acetylation is increased in human pancreatic tumors, which correlates with reduced SIRT3 expression.
24955214	Breast Carcinoma	downstream	SOD2; ROS	positive regulation; negative regulation	Recently, SIRT3 was reported to be decreased in 87% of breast cancers, resulting therefore in a decrease in the activity of SOD2 and an elevation in ROS.
24287180	Gastric Carcinoma	partner	HIF-1α	negative correlation	In vitro experiment showed that knockdown of SIRT3 in MGC-803 gastric cancer cells significantly increased the expression of HIF-1α.
23842789	Lung Adenocarcinoma	downstream	p53; p21; ROS	positive regulation; positive regulation; negative regulation	Finally, Sirt3 overexpression upregulated p53 and p21 protein levels, and decreased intracellular ROS levels.
22609775	Hepatocellular Carcinoma	downstream	p53; Mdm2	positive regulation; negative regulation	Furthermore, Sirt3 overexpression upregulated p53 protein level through downregulating Mdm2 and thereby slowing p53 degradation.
21397863	Breast Carcinoma	downstream	HIF1α	negative regulation	SIRT3 loss increases reactive oxygen species production, leading to HIF1α stabilization.
28197634	Non-Small Cell Lung Carcinoma	partner	Ki-67; p-Akt	Positive correlation	Expression of SIRT3 in NSCLC positively correlated with that of malignant biomarker Ki-67 (P<0.05) and oncogene p-Akt (P<0.05).
27420645	Breast Carcinoma	downstream	PGC-1α; TFAM; MnSOD ; IDH2	Regulation	SIRT3 knockdown also affected PGC-1α and TFAM (mitochondrial biogenesis), and MnSOD and IDH2 (antioxidant defenses) protein levels.