CR2Cancer

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02146 Sir2 family

Function

Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0000820 regulation of glutamine family amino acid metabolic process GO:0001666 response to hypoxia GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0006342 chromatin silencing GO:0006471 protein ADP-ribosylation GO:0006476 protein deacetylation GO:0006486 protein glycosylation GO:0006520 cellular amino acid metabolic process GO:0006541 glutamine metabolic process GO:0006626 protein targeting to mitochondrion GO:0006627 protein processing involved in protein targeting to mitochondrion GO:0006631 fatty acid metabolic process GO:0006839 mitochondrial transport GO:0009064 glutamine family amino acid metabolic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009306 protein secretion GO:0009914 hormone transport GO:0010565 regulation of cellular ketone metabolic process GO:0010639 negative regulation of organelle organization GO:0010656 negative regulation of muscle cell apoptotic process GO:0010657 muscle cell apoptotic process GO:0010658 striated muscle cell apoptotic process GO:0010659 cardiac muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010662 regulation of striated muscle cell apoptotic process GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0010665 regulation of cardiac muscle cell apoptotic process GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0010817 regulation of hormone levels GO:0010821 regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0010955 negative regulation of protein processing GO:0015833 peptide transport GO:0016458 gene silencing GO:0016485 protein processing GO:0018205 peptidyl-lysine modification GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030258 lipid modification GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034440 lipid oxidation GO:0034982 mitochondrial protein processing GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040029 regulation of gene expression, epigenetic GO:0042180 cellular ketone metabolic process GO:0042886 amide transport GO:0043413 macromolecule glycosylation GO:0045814 negative regulation of gene expression, epigenetic GO:0045833 negative regulation of lipid metabolic process GO:0045834 positive regulation of lipid metabolic process GO:0045861 negative regulation of proteolysis GO:0045922 negative regulation of fatty acid metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046322 negative regulation of fatty acid oxidation GO:0046676 negative regulation of insulin secretion GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0051341 regulation of oxidoreductase activity GO:0051604 protein maturation GO:0070085 glycosylation GO:0070482 response to oxygen levels GO:0070585 protein localization to mitochondrion GO:0070613 regulation of protein processing GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0072350 tricarboxylic acid metabolic process GO:0072655 establishment of protein localization to mitochondrion GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090278 negative regulation of peptide hormone secretion GO:0090317 negative regulation of intracellular protein transport GO:0098732 macromolecule deacylation GO:1901605 alpha-amino acid metabolic process GO:1903214 regulation of protein targeting to mitochondrion GO:1903215 negative regulation of protein targeting to mitochondrion GO:1903216 regulation of protein processing involved in protein targeting to mitochondrion GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:1903531 negative regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903748 negative regulation of establishment of protein localization to mitochondrion GO:1903828 negative regulation of cellular protein localization GO:1904182 regulation of pyruvate dehydrogenase activity GO:1904950 negative regulation of establishment of protein localization
Molecular Function	GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016763 transferase activity, transferring pentosyl groups GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0047708 biotinidase activity GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0061690 lipoamidase activity GO:0070403 NAD+ binding
Cellular Component	GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5778172	c.659G>A	p.C220Y	Substitution - Missense	Breast
COSM467894	c.239G>T	p.G80V	Substitution - Missense	Kidney
COSM277279	c.547G>T	p.E183*	Substitution - Nonsense	Large_intestine
COSM5753883	c.649G>T	p.V217F	Substitution - Missense	Large_intestine
COSM935907	c.905C>A	p.S302Y	Substitution - Missense	Endometrium
COSM935905	c.759C>T	p.A253A	Substitution - coding silent	Endometrium
COSM5374381	c.155C>T	p.T52I	Substitution - Missense	Skin
COSM5925719	c.110C>T	p.P37L	Substitution - Missense	Skin
COSM1178773	c.18G>T	p.A6A	Substitution - coding silent	Prostate
COSM4039394	c.361C>T	p.P121S	Substitution - Missense	Stomach
COSM4822159	c.44G>A	p.R15H	Substitution - Missense	Cervix
COSM1359362	c.533delG	p.V180fs*9	Deletion - Frameshift	Large_intestine
COSM4611890	c.631_632insA	p.V212fs*30	Insertion - Frameshift	Large_intestine
COSM4760700	c.730G>A	p.D244N	Substitution - Missense	Stomach
COSM1605652	c.792+3A>G	p.?	Unknown	Liver
COSM2175139	c.550C>T	p.R184C	Substitution - Missense	Upper_aerodigestive_tract
COSM1359362	c.533delG	p.V180fs*9	Deletion - Frameshift	Large_intestine
COSM1717550	c.914G>A	p.G305E	Substitution - Missense	Ovary
COSM3368678	c.290G>A	p.R97Q	Substitution - Missense	Thyroid
COSM935903	c.12C>T	p.S4S	Substitution - coding silent	Endometrium
COSM3457030	c.69G>A	p.P23P	Substitution - coding silent	Bone
COSM1638223	c.531C>T	p.P177P	Substitution - coding silent	Bone
COSM4726201	c.157C>T	p.L53F	Substitution - Missense	Large_intestine
COSM3457034	c.892C>A	p.L298M	Substitution - Missense	Skin
COSM4835759	c.555C>G	p.F185L	Substitution - Missense	Cervix
COSM4833426	c.693C>G	p.V231V	Substitution - coding silent	Cervix
COSM145934	c.466C>T	p.R156C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM145934	c.466C>T	p.R156C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1677406	c.404G>T	p.G135V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5341920	c.484G>A	p.G162R	Substitution - Missense	Large_intestine
COSM4726199	c.17C>T	p.A6V	Substitution - Missense	Large_intestine
COSM1664170	c.467G>A	p.R156H	Substitution - Missense	Kidney
COSM2175134	c.482A>G	p.H161R	Substitution - Missense	Large_intestine
COSM4887745	c.572C>A	p.T191N	Substitution - Missense	Upper_aerodigestive_tract
COSM145934	c.466C>T	p.R156C	Substitution - Missense	Prostate
COSM4834096	c.623C>T	p.S208L	Substitution - Missense	Cervix
COSM3457030	c.69G>A	p.P23P	Substitution - coding silent	Skin
COSM4498934	c.530C>T	p.P177L	Substitution - Missense	Skin
COSM691793	c.451A>G	p.K151E	Substitution - Missense	Lung
COSM935904	c.146G>A	p.R49H	Substitution - Missense	Endometrium
COSM4575092	c.532C>A	p.R178R	Substitution - coding silent	Bone
COSM3457031	c.330C>T	p.F110F	Substitution - coding silent	Skin
COSM4039395	c.903T>C	p.N301N	Substitution - coding silent	Stomach
COSM3416548	c.612C>T	p.D204D	Substitution - coding silent	Large_intestine
COSM1188625	c.718C>T	p.P240S	Substitution - Missense	Lung
COSM4501469	c.589C>T	p.H197Y	Substitution - Missense	Skin
COSM393210	c.68C>G	p.P23R	Substitution - Missense	Lung
COSM5430699	c.202G>T	p.E68*	Substitution - Nonsense	Oesophagus
COSM5929456	c.793-7C>T	p.?	Unknown	Skin
COSM1605652	c.792+3A>G	p.?	Unknown	Liver
COSM3457033	c.636C>T	p.V212V	Substitution - coding silent	Skin
COSM3368678	c.290G>A	p.R97Q	Substitution - Missense	Oesophagus
COSM1225797	c.311G>A	p.R104Q	Substitution - Missense	Large_intestine
COSM4726202	c.533G>A	p.R178Q	Substitution - Missense	Large_intestine
COSM1161037	c.480C>T	p.L160L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4726200	c.104C>T	p.A35V	Substitution - Missense	Large_intestine
COSM2175129	c.259C>T	p.R87C	Substitution - Missense	Skin
COSM1225798	c.694G>A	p.V232I	Substitution - Missense	Large_intestine
COSM4652144	c.847G>A	p.A283T	Substitution - Missense	Large_intestine
COSM5374382	c.840C>T	p.L280L	Substitution - coding silent	Skin
COSM4039396	c.908G>A	p.R303H	Substitution - Missense	Stomach
COSM1677406	c.404G>T	p.G135V	Substitution - Missense	Skin
COSM5654544	c.586G>T	p.A196S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3457032	c.389C>T	p.T130I	Substitution - Missense	Skin
COSM1717550	c.914G>A	p.G305E	Substitution - Missense	Ovary
COSM4928766	c.51C>T	p.I17I	Substitution - coding silent	Liver
COSM4510858	c.84C>T	p.S28S	Substitution - coding silent	Skin
COSM2175146	c.872G>A	p.R291Q	Substitution - Missense	Large_intestine
COSM935906	c.843G>A	p.P281P	Substitution - coding silent	Endometrium
COSM4904692	c.866C>T	p.P289L	Substitution - Missense	Skin
COSM3670990	c.533G>T	p.R178L	Substitution - Missense	Prostate
COSM1359363	c.656C>T	p.T219I	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for SIRT4.

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	-1.06	-0.698	-0.028	0.94	NS
BRCA	Breast invasive carcinoma	112	1100	0.488	0.054	-0.433	1.82e-08	NS
CESC	Cervical and endocervical cancers	3	306	0.775	-0.131	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	-0.382	-1.165	-0.917	1.25e-08	Under
ESCA	Esophageal carcinoma	11	185	-0.664	-1.463	-0.95	0.027	Under
GBM	Glioblastoma multiforme	5	166	1.034	0.647	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	-0.154	-0.768	-0.527	0.00168	NS
KIRC	Kidney renal clear cell carcinoma	72	534	1.421	0.415	-0.931	1.82e-20	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	1.67	1.11	-0.46	0.0106	NS
LAML	Acute Myeloid Leukemia	0	173	NA	-1.031	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	0.91	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	0.724	1.043	0.359	0.00554	NS
LUAD	Lung adenocarcinoma	59	517	0.184	0.179	0.147	0.231	NS
LUSC	Lung squamous cell carcinoma	51	501	0.024	-0.617	-0.515	8.08e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	-0.113	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	0.239	-0.236	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.53	-0.599	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.278	0.402	0.124	0.259	NS
READ	Rectum adenocarcinoma	10	167	-0.028	-1.305	-1.048	0.00171	Under
SARC	Sarcoma	2	263	1.346	0.542	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	0.284	0.009	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	0.036	-1.105	-1.083	6.39e-08	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	0.217	NA	NA	NA
THCA	Thyroid carcinoma	59	509	0.795	0.161	-0.577	7.66e-07	NS
THYM	Thymoma	2	120	0.573	0.587	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	0.941	0.391	-0.554	0.000161	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6
Autonomic ganglia	CHP212	4.7
Autonomic ganglia	IMR32	5.7
Autonomic ganglia	KELLY	4.6
Autonomic ganglia	KPNRTBM1	5.9
Autonomic ganglia	KPNSI9S	4.4
Autonomic ganglia	KPNYN	4.4
Autonomic ganglia	MHHNB11	5.2
Autonomic ganglia	NB1	4.9
Autonomic ganglia	NH6	4.8
Autonomic ganglia	SHSY5Y	5.8
Autonomic ganglia	SIMA	4.2
Autonomic ganglia	SKNAS	5.2
Autonomic ganglia	SKNBE2	6
Autonomic ganglia	SKNDZ	4.7
Autonomic ganglia	SKNFI	4.7
Autonomic ganglia	SKNSH	4.1
Biliary tract	HUCCT1	3.8
Biliary tract	HUH28	4
Biliary tract	SNU1079	3.8
Biliary tract	SNU1196	4.1
Biliary tract	SNU245	4.1
Biliary tract	SNU308	4.2
Biliary tract	SNU478	4
Bone	143B	4.1
Bone	A673	5.2
Bone	CADOES1	4.3
Bone	CAL78	4.6
Bone	G292CLONEA141B1	4.3
Bone	HOS	4.9
Bone	HS706T	4.3
Bone	HS737T	4.6
Bone	HS819T	4.6
Bone	HS821T	4.1
Bone	HS822T	4.4
Bone	HS863T	4.2
Bone	HS870T	4.4
Bone	HS888T	4.4
Bone	MG63	4.3
Bone	MHHES1	6.8
Bone	OUMS27	5.1
Bone	RDES	5.2
Bone	SJSA1	3.9
Bone	SKES1	5.7
Bone	SKNMC	5.4
Bone	SW1353	4.3
Bone	T173	4.4
Bone	TC71	5.7
Bone	U2OS	4.5
Breast	AU565	3.8
Breast	BT20	4
Breast	BT474	5.2
Breast	BT483	4.9
Breast	BT549	4.2
Breast	CAL120	4.3
Breast	CAL148	4.8
Breast	CAL51	4
Breast	CAL851	4.8
Breast	CAMA1	4.1
Breast	DU4475	4.3
Breast	EFM192A	5.6
Breast	EFM19	4.7
Breast	EVSAT	4
Breast	HCC1143	4.2
Breast	HCC1187	4.6
Breast	HCC1395	4.2
Breast	HCC1419	4.9
Breast	HCC1428	4.5
Breast	HCC1500	4.8
Breast	HCC1569	4.5
Breast	HCC1599	4
Breast	HCC1806	4.6
Breast	HCC1937	4
Breast	HCC1954	4.6
Breast	HCC202	6
Breast	HCC2157	5.3
Breast	HCC2218	4.5
Breast	HCC38	4.5
Breast	HCC70	3.8
Breast	HDQP1	4.4
Breast	HMC18	4.8
Breast	HS274T	4.3
Breast	HS281T	4
Breast	HS343T	4.2
Breast	HS578T	4.2
Breast	HS606T	4.3
Breast	HS739T	4.3
Breast	HS742T	4.2
Breast	JIMT1	4.9
Breast	KPL1	4.5
Breast	MCF7	4.7
Breast	MDAMB134VI	4.1
Breast	MDAMB157	4.8
Breast	MDAMB175VII	4.4
Breast	MDAMB231	4.3
Breast	MDAMB361	4.1
Breast	MDAMB415	4.2
Breast	MDAMB436	5.4
Breast	MDAMB453	4
Breast	MDAMB468	4.3
Breast	SKBR3	4
Breast	T47D	5.6
Breast	UACC812	4.2
Breast	UACC893	4
Breast	YMB1	4.2
Breast	ZR751	4.7
Breast	ZR7530	4.2
Central nervous system	1321N1	4.3
Central nervous system	42MGBA	4.5
Central nervous system	8MGBA	4.7
Central nervous system	A172	4.4
Central nervous system	AM38	4.4
Central nervous system	BECKER	4.4
Central nervous system	CAS1	5
Central nervous system	CCFSTTG1	4
Central nervous system	D283MED	4.8
Central nervous system	D341MED	6.9
Central nervous system	DAOY	4.6
Central nervous system	DBTRG05MG	5
Central nervous system	DKMG	4.4
Central nervous system	GAMG	4.2
Central nervous system	GB1	4.2
Central nervous system	GI1	5
Central nervous system	GMS10	4.3
Central nervous system	GOS3	5.1
Central nervous system	H4	4.9
Central nervous system	HS683	4.3
Central nervous system	KALS1	4.4
Central nervous system	KG1C	5.5
Central nervous system	KNS42	4.4
Central nervous system	KNS60	4.6
Central nervous system	KNS81	4.2
Central nervous system	KS1	4.1
Central nervous system	LN18	4.3
Central nervous system	LN229	4
Central nervous system	M059K	4.1
Central nervous system	MOGGCCM	4.5
Central nervous system	MOGGUVW	5.1
Central nervous system	NMCG1	4.1
Central nervous system	ONS76	4.1
Central nervous system	SF126	4.5
Central nervous system	SF295	4.6
Central nervous system	SNB19	3.9
Central nervous system	SNU1105	4
Central nervous system	SNU201	4.7
Central nervous system	SNU466	4.6
Central nervous system	SNU489	4.5
Central nervous system	SNU626	4.3
Central nervous system	SNU738	4.3
Central nervous system	SW1088	4.6
Central nervous system	SW1783	5.4
Central nervous system	T98G	4.6
Central nervous system	TM31	4.8
Central nervous system	U118MG	3.9
Central nervous system	U138MG	4.2
Central nervous system	U251MG	4.3
Central nervous system	U87MG	4.1
Central nervous system	YH13	4.6
Central nervous system	YKG1	4.7
Endometrium	AN3CA	4.4
Endometrium	COLO684	5.6
Endometrium	EFE184	4.3
Endometrium	EN	4.4
Endometrium	ESS1	4.4
Endometrium	HEC108	4.9
Endometrium	HEC151	4.2
Endometrium	HEC1A	4.1
Endometrium	HEC1B	4.5
Endometrium	HEC251	4.2
Endometrium	HEC265	4
Endometrium	HEC50B	4
Endometrium	HEC59	4.2
Endometrium	HEC6	5.7
Endometrium	ISHIKAWAHERAKLIO02ER	4.6
Endometrium	JHUEM1	4.2
Endometrium	JHUEM2	4.8
Endometrium	JHUEM3	4
Endometrium	KLE	4.6
Endometrium	MFE280	4.4
Endometrium	MFE296	4.4
Endometrium	MFE319	4.9
Endometrium	RL952	4.5
Endometrium	SNGM	5.2
Endometrium	SNU1077	4.6
Endometrium	SNU685	4.4
Endometrium	TEN	3.8
Haematopoietic and lymphoid	697	4.4
Haematopoietic and lymphoid	A3KAW	5.3
Haematopoietic and lymphoid	A4FUK	5
Haematopoietic and lymphoid	ALLSIL	4.3
Haematopoietic and lymphoid	AML193	4
Haematopoietic and lymphoid	AMO1	4.8
Haematopoietic and lymphoid	BCP1	4.3
Haematopoietic and lymphoid	BDCM	4
Haematopoietic and lymphoid	BL41	3.8
Haematopoietic and lymphoid	BL70	4.8
Haematopoietic and lymphoid	BV173	4.7
Haematopoietic and lymphoid	CA46	4.9
Haematopoietic and lymphoid	CI1	4.2
Haematopoietic and lymphoid	CMK115	4.2
Haematopoietic and lymphoid	CMK86	4.2
Haematopoietic and lymphoid	CMK	4.4
Haematopoietic and lymphoid	CMLT1	4.5
Haematopoietic and lymphoid	COLO775	4.6
Haematopoietic and lymphoid	DAUDI	4.5
Haematopoietic and lymphoid	DB	5
Haematopoietic and lymphoid	DEL	5
Haematopoietic and lymphoid	DND41	5.3
Haematopoietic and lymphoid	DOHH2	4
Haematopoietic and lymphoid	EB1	5.5
Haematopoietic and lymphoid	EB2	5
Haematopoietic and lymphoid	EHEB	4
Haematopoietic and lymphoid	EJM	5.6
Haematopoietic and lymphoid	EM2	4.2
Haematopoietic and lymphoid	EOL1	4.3
Haematopoietic and lymphoid	F36P	4
Haematopoietic and lymphoid	GA10	4
Haematopoietic and lymphoid	GDM1	4.3
Haematopoietic and lymphoid	GRANTA519	5
Haematopoietic and lymphoid	HDLM2	4.9
Haematopoietic and lymphoid	HDMYZ	4.6
Haematopoietic and lymphoid	HEL9217	4
Haematopoietic and lymphoid	HEL	3.8
Haematopoietic and lymphoid	HH	5.5
Haematopoietic and lymphoid	HL60	3.9
Haematopoietic and lymphoid	HPBALL	6.2
Haematopoietic and lymphoid	HS604T	4.3
Haematopoietic and lymphoid	HS611T	4.3
Haematopoietic and lymphoid	HS616T	4.6
Haematopoietic and lymphoid	HS751T	4.3
Haematopoietic and lymphoid	HT	4.3
Haematopoietic and lymphoid	HTK	4.3
Haematopoietic and lymphoid	HUNS1	4.2
Haematopoietic and lymphoid	HUT102	4.7
Haematopoietic and lymphoid	HUT78	4.8
Haematopoietic and lymphoid	JEKO1	6.6
Haematopoietic and lymphoid	JK1	4.1
Haematopoietic and lymphoid	JM1	4.2
Haematopoietic and lymphoid	JURKAT	5.8
Haematopoietic and lymphoid	JURLMK1	4.4
Haematopoietic and lymphoid	JVM2	4
Haematopoietic and lymphoid	JVM3	4.5
Haematopoietic and lymphoid	K562	5.7
Haematopoietic and lymphoid	KARPAS299	5.1
Haematopoietic and lymphoid	KARPAS422	4.3
Haematopoietic and lymphoid	KARPAS620	4.4
Haematopoietic and lymphoid	KASUMI1	4.5
Haematopoietic and lymphoid	KASUMI2	4.7
Haematopoietic and lymphoid	KASUMI6	4.1
Haematopoietic and lymphoid	KCL22	4.3
Haematopoietic and lymphoid	KE37	5.1
Haematopoietic and lymphoid	KE97	4.1
Haematopoietic and lymphoid	KG1	4.6
Haematopoietic and lymphoid	KHM1B	5.2
Haematopoietic and lymphoid	KIJK	4.3
Haematopoietic and lymphoid	KMH2	5.8
Haematopoietic and lymphoid	KMM1	5.1
Haematopoietic and lymphoid	KMS11	4.5
Haematopoietic and lymphoid	KMS12BM	6.7
Haematopoietic and lymphoid	KMS18	4.4
Haematopoietic and lymphoid	KMS20	4.6
Haematopoietic and lymphoid	KMS21BM	4.6
Haematopoietic and lymphoid	KMS26	5.1
Haematopoietic and lymphoid	KMS27	5.4
Haematopoietic and lymphoid	KMS28BM	5.9
Haematopoietic and lymphoid	KMS34	5.3
Haematopoietic and lymphoid	KO52	4.5
Haematopoietic and lymphoid	KOPN8	4.4
Haematopoietic and lymphoid	KU812	4
Haematopoietic and lymphoid	KYO1	4.9
Haematopoietic and lymphoid	L1236	4.6
Haematopoietic and lymphoid	L363	5.3
Haematopoietic and lymphoid	L428	4.3
Haematopoietic and lymphoid	L540	5.3
Haematopoietic and lymphoid	LAMA84	4.5
Haematopoietic and lymphoid	LOUCY	4
Haematopoietic and lymphoid	LP1	5.3
Haematopoietic and lymphoid	M07E	4.1
Haematopoietic and lymphoid	MC116	5
Haematopoietic and lymphoid	ME1	4.1
Haematopoietic and lymphoid	MEC1	5.1
Haematopoietic and lymphoid	MEC2	4.2
Haematopoietic and lymphoid	MEG01	4.8
Haematopoietic and lymphoid	MHHCALL2	4.2
Haematopoietic and lymphoid	MHHCALL3	4.4
Haematopoietic and lymphoid	MHHCALL4	4.7
Haematopoietic and lymphoid	MINO	4.7
Haematopoietic and lymphoid	MJ	4.9
Haematopoietic and lymphoid	MM1S	4
Haematopoietic and lymphoid	MOLM13	4.5
Haematopoietic and lymphoid	MOLM16	5
Haematopoietic and lymphoid	MOLM6	4.8
Haematopoietic and lymphoid	MOLP2	5.3
Haematopoietic and lymphoid	MOLP8	4.7
Haematopoietic and lymphoid	MOLT13	4.4
Haematopoietic and lymphoid	MOLT16	5.2
Haematopoietic and lymphoid	MOLT4	5.3
Haematopoietic and lymphoid	MONOMAC1	4.5
Haematopoietic and lymphoid	MONOMAC6	4.7
Haematopoietic and lymphoid	MOTN1	5.3
Haematopoietic and lymphoid	MUTZ5	5.2
Haematopoietic and lymphoid	MV411	4.3
Haematopoietic and lymphoid	NALM19	4.3
Haematopoietic and lymphoid	NALM1	5.2
Haematopoietic and lymphoid	NALM6	5.8
Haematopoietic and lymphoid	NAMALWA	5.7
Haematopoietic and lymphoid	NB4	4.5
Haematopoietic and lymphoid	NCIH929	4.6
Haematopoietic and lymphoid	NCO2	4.4
Haematopoietic and lymphoid	NOMO1	4.2
Haematopoietic and lymphoid	NUDHL1	4.9
Haematopoietic and lymphoid	NUDUL1	5.2
Haematopoietic and lymphoid	OCIAML2	4.2
Haematopoietic and lymphoid	OCIAML3	4.9
Haematopoietic and lymphoid	OCIAML5	4.2
Haematopoietic and lymphoid	OCILY10	4
Haematopoietic and lymphoid	OCILY19	4.3
Haematopoietic and lymphoid	OCILY3	4.8
Haematopoietic and lymphoid	OCIM1	4.1
Haematopoietic and lymphoid	OPM2	5
Haematopoietic and lymphoid	P12ICHIKAWA	4.4
Haematopoietic and lymphoid	P31FUJ	4.3
Haematopoietic and lymphoid	P3HR1	4.1
Haematopoietic and lymphoid	PCM6	4.7
Haematopoietic and lymphoid	PEER	4.4
Haematopoietic and lymphoid	PF382	5.5
Haematopoietic and lymphoid	PFEIFFER	4.2
Haematopoietic and lymphoid	PL21	4.2
Haematopoietic and lymphoid	RAJI	4.6
Haematopoietic and lymphoid	RCHACV	5.1
Haematopoietic and lymphoid	REC1	4.7
Haematopoietic and lymphoid	REH	5.5
Haematopoietic and lymphoid	RI1	4.2
Haematopoietic and lymphoid	RL	4.1
Haematopoietic and lymphoid	RPMI8226	3.9
Haematopoietic and lymphoid	RPMI8402	4.6
Haematopoietic and lymphoid	RS411	4.4
Haematopoietic and lymphoid	SEM	4.1
Haematopoietic and lymphoid	SET2	5.2
Haematopoietic and lymphoid	SIGM5	4.1
Haematopoietic and lymphoid	SKM1	4.4
Haematopoietic and lymphoid	SKMM2	4.3
Haematopoietic and lymphoid	SR786	4.7
Haematopoietic and lymphoid	ST486	5
Haematopoietic and lymphoid	SUDHL10	4.8
Haematopoietic and lymphoid	SUDHL1	4.9
Haematopoietic and lymphoid	SUDHL4	4.3
Haematopoietic and lymphoid	SUDHL5	4
Haematopoietic and lymphoid	SUDHL6	5
Haematopoietic and lymphoid	SUDHL8	5.1
Haematopoietic and lymphoid	SUPB15	4.9
Haematopoietic and lymphoid	SUPHD1	6.8
Haematopoietic and lymphoid	SUPM2	5.6
Haematopoietic and lymphoid	SUPT11	5
Haematopoietic and lymphoid	SUPT1	4.8
Haematopoietic and lymphoid	TALL1	6.2
Haematopoietic and lymphoid	TF1	4.4
Haematopoietic and lymphoid	THP1	4.6
Haematopoietic and lymphoid	TO175T	4.3
Haematopoietic and lymphoid	TOLEDO	5.3
Haematopoietic and lymphoid	U266B1	4.9
Haematopoietic and lymphoid	U937	4.9
Haematopoietic and lymphoid	UT7	4.6
Haematopoietic and lymphoid	WSUDLCL2	4.4
Kidney	769P	4
Kidney	786O	3.9
Kidney	A498	4.2
Kidney	A704	4.5
Kidney	ACHN	4.2
Kidney	BFTC909	4
Kidney	CAKI1	4.3
Kidney	CAKI2	4
Kidney	CAL54	4.2
Kidney	KMRC1	3.9
Kidney	KMRC20	3.9
Kidney	KMRC2	4
Kidney	KMRC3	4.7
Kidney	OSRC2	4.1
Kidney	RCC10RGB	3.9
Kidney	SNU1272	4.2
Kidney	SNU349	4.5
Kidney	TUHR10TKB	3.8
Kidney	TUHR14TKB	4.3
Kidney	TUHR4TKB	4.7
Kidney	VMRCRCW	4.2
Kidney	VMRCRCZ	4
Large intestine	C2BBE1	4.5
Large intestine	CCK81	3.7
Large intestine	CL11	4.2
Large intestine	CL14	4.4
Large intestine	CL34	4.2
Large intestine	CL40	4.3
Large intestine	COLO205	4.3
Large intestine	COLO320	5.8
Large intestine	COLO678	4.3
Large intestine	CW2	4.1
Large intestine	DLD1	4.7
Large intestine	GP2D	4.1
Large intestine	HCC56	4.1
Large intestine	HCT116	4.3
Large intestine	HCT15	4.8
Large intestine	HS675T	4.2
Large intestine	HS698T	4.8
Large intestine	HT115	4.3
Large intestine	HT29	4.1
Large intestine	HT55	4.2
Large intestine	KM12	4.4
Large intestine	LOVO	4.9
Large intestine	LS1034	3.9
Large intestine	LS123	4.7
Large intestine	LS180	4
Large intestine	LS411N	3.9
Large intestine	LS513	4.3
Large intestine	MDST8	4.9
Large intestine	NCIH508	4.3
Large intestine	NCIH716	5.9
Large intestine	NCIH747	3.7
Large intestine	OUMS23	7.1
Large intestine	RCM1	4.1
Large intestine	RKO	4.3
Large intestine	SKCO1	3.7
Large intestine	SNU1040	4.2
Large intestine	SNU1197	4.2
Large intestine	SNU175	4.4
Large intestine	SNU283	3.9
Large intestine	SNU407	4.1
Large intestine	SNU503	4.8
Large intestine	SNU61	4
Large intestine	SNU81	4.7
Large intestine	SNUC1	4
Large intestine	SNUC2A	5.1
Large intestine	SNUC4	4.3
Large intestine	SNUC5	4.4
Large intestine	SW1116	3.9
Large intestine	SW1417	4.3
Large intestine	SW1463	4
Large intestine	SW403	4.2
Large intestine	SW480	4.8
Large intestine	SW48	4.1
Large intestine	SW620	4.1
Large intestine	SW837	4.7
Large intestine	SW948	4.6
Large intestine	T84	4.5
Liver	ALEXANDERCELLS	4.4
Liver	C3A	4.7
Liver	HEP3B217	4.4
Liver	HEPG2	5.3
Liver	HLE	4.2
Liver	HLF	4.3
Liver	HUH1	5.3
Liver	HUH6	4.5
Liver	HUH7	4.9
Liver	JHH1	6.1
Liver	JHH2	4.3
Liver	JHH4	3.9
Liver	JHH5	4.8
Liver	JHH6	4.4
Liver	JHH7	5.3
Liver	LI7	5.2
Liver	PLCPRF5	4.9
Liver	SKHEP1	4.3
Liver	SNU182	4.3
Liver	SNU387	4
Liver	SNU398	4.6
Liver	SNU423	4.3
Liver	SNU449	4.2
Liver	SNU475	4.5
Liver	SNU761	4.6
Liver	SNU878	4
Liver	SNU886	4.1
Lung	A549	4.4
Lung	ABC1	4.1
Lung	BEN	4.8
Lung	CAL12T	4.6
Lung	CALU1	3.9
Lung	CALU3	4
Lung	CALU6	4
Lung	CHAGOK1	4.2
Lung	COLO668	3.9
Lung	COLO699	4.1
Lung	CORL105	4.7
Lung	CORL23	4.1
Lung	CORL24	4.6
Lung	CORL279	4.2
Lung	CORL311	5.4
Lung	CORL47	4.1
Lung	CORL51	4.5
Lung	CORL88	4
Lung	CORL95	3.8
Lung	CPCN	4.1
Lung	DMS114	4.7
Lung	DMS153	4.2
Lung	DMS273	4.7
Lung	DMS454	4.2
Lung	DMS53	5
Lung	DMS79	4.1
Lung	DV90	4
Lung	EBC1	4.1
Lung	EPLC272H	4.2
Lung	HARA	4.2
Lung	HCC1171	4.1
Lung	HCC1195	4.9
Lung	HCC15	4.6
Lung	HCC2279	4.2
Lung	HCC2935	4
Lung	HCC33	3.9
Lung	HCC366	4.2
Lung	HCC4006	3.9
Lung	HCC44	4
Lung	HCC78	4
Lung	HCC827	4.4
Lung	HCC95	4
Lung	HLC1	4.8
Lung	HLFA	4.8
Lung	HS229T	4.1
Lung	HS618T	4.2
Lung	IALM	4.5
Lung	KNS62	4.2
Lung	LC1F	4.3
Lung	LC1SQSF	4.4
Lung	LCLC103H	4.6
Lung	LCLC97TM1	4
Lung	LK2	4.1
Lung	LOUNH91	4
Lung	LU65	4.5
Lung	LU99	4.2
Lung	LUDLU1	4.2
Lung	LXF289	5.7
Lung	MORCPR	4.6
Lung	NCIH1048	4.9
Lung	NCIH1092	3.8
Lung	NCIH1105	4.2
Lung	NCIH1155	4.1
Lung	NCIH1184	4.5
Lung	NCIH1299	4.4
Lung	NCIH1339	4.1
Lung	NCIH1341	4.9
Lung	NCIH1355	4.5
Lung	NCIH1373	4.1
Lung	NCIH1385	4.2
Lung	NCIH1395	4.9
Lung	NCIH1435	3.9
Lung	NCIH1436	3.8
Lung	NCIH1437	4
Lung	NCIH146	3.9
Lung	NCIH1563	4.3
Lung	NCIH1568	3.9
Lung	NCIH1573	4.5
Lung	NCIH1581	6.3
Lung	NCIH1618	4.4
Lung	NCIH1623	3.9
Lung	NCIH1648	4.2
Lung	NCIH1650	3.9
Lung	NCIH1651	4.2
Lung	NCIH1666	3.9
Lung	NCIH1693	4.8
Lung	NCIH1694	5.1
Lung	NCIH1703	4.1
Lung	NCIH1734	4.8
Lung	NCIH1755	4.3
Lung	NCIH1781	4.6
Lung	NCIH1792	4.1
Lung	NCIH1793	4.6
Lung	NCIH1836	4
Lung	NCIH1838	4.8
Lung	NCIH1869	3.9
Lung	NCIH1876	4.5
Lung	NCIH1915	4.3
Lung	NCIH1930	5.2
Lung	NCIH1944	4
Lung	NCIH1963	3.9
Lung	NCIH196	3.9
Lung	NCIH1975	4.7
Lung	NCIH2009	3.8
Lung	NCIH2023	4.4
Lung	NCIH2029	4.5
Lung	NCIH2030	4.1
Lung	NCIH2066	4.7
Lung	NCIH2081	5.1
Lung	NCIH2085	4.4
Lung	NCIH2087	4.2
Lung	NCIH209	4
Lung	NCIH2106	4.5
Lung	NCIH2110	4.3
Lung	NCIH211	4.9
Lung	NCIH2122	3.9
Lung	NCIH2126	4.6
Lung	NCIH2141	4.1
Lung	NCIH2170	4.1
Lung	NCIH2171	4.1
Lung	NCIH2172	4.3
Lung	NCIH2196	4.4
Lung	NCIH2227	4.9
Lung	NCIH2228	4.1
Lung	NCIH226	4.2
Lung	NCIH2286	4.9
Lung	NCIH2291	4
Lung	NCIH2342	4.6
Lung	NCIH2347	4.1
Lung	NCIH23	4.8
Lung	NCIH2405	4.2
Lung	NCIH2444	4.7
Lung	NCIH292	3.8
Lung	NCIH322	4.3
Lung	NCIH3255	4
Lung	NCIH358	3.9
Lung	NCIH441	4.1
Lung	NCIH446	4.7
Lung	NCIH460	4.1
Lung	NCIH510	4.1
Lung	NCIH520	3.7
Lung	NCIH522	5.4
Lung	NCIH524	4.4
Lung	NCIH526	4.3
Lung	NCIH596	4.2
Lung	NCIH647	4.2
Lung	NCIH650	5.5
Lung	NCIH661	4.7
Lung	NCIH69	3.9
Lung	NCIH727	4.3
Lung	NCIH810	3.8
Lung	NCIH82	5.3
Lung	NCIH838	4
Lung	NCIH841	5.2
Lung	NCIH854	4.1
Lung	NCIH889	4.6
Lung	PC14	4.4
Lung	RERFLCAD1	4.3
Lung	RERFLCAD2	4.2
Lung	RERFLCAI	4.8
Lung	RERFLCKJ	4.8
Lung	RERFLCMS	4.9
Lung	RERFLCSQ1	4.1
Lung	SBC5	4.9
Lung	SCLC21H	5.3
Lung	SHP77	4
Lung	SKLU1	4.4
Lung	SKMES1	4
Lung	SQ1	4
Lung	SW1271	4.3
Lung	SW1573	5.4
Lung	SW900	4.2
Lung	VMRCLCD	4.3
Lung	VMRCLCP	4.2
Oesophagus	COLO680N	4.9
Oesophagus	ECGI10	4.9
Oesophagus	KYSE140	4
Oesophagus	KYSE150	4.2
Oesophagus	KYSE180	3.9
Oesophagus	KYSE270	4.2
Oesophagus	KYSE30	4.8
Oesophagus	KYSE410	3.9
Oesophagus	KYSE450	4.3
Oesophagus	KYSE510	4
Oesophagus	KYSE520	4.6
Oesophagus	KYSE70	4.2
Oesophagus	OE19	4.1
Oesophagus	OE33	3.8
Oesophagus	TE10	4.1
Oesophagus	TE11	3.8
Oesophagus	TE14	4
Oesophagus	TE15	3.9
Oesophagus	TE1	5
Oesophagus	TE4	3.8
Oesophagus	TE5	4.2
Oesophagus	TE6	4.1
Oesophagus	TE8	6.6
Oesophagus	TE9	4.1
Oesophagus	TT	4.2
Ovary	59M	4.3
Ovary	A2780	4.9
Ovary	CAOV3	4.3
Ovary	CAOV4	5.8
Ovary	COLO704	4.8
Ovary	COV318	4.7
Ovary	COV362	4
Ovary	COV434	5
Ovary	COV504	3.9
Ovary	COV644	3.9
Ovary	EFO21	4.1
Ovary	EFO27	6.1
Ovary	ES2	3.9
Ovary	FUOV1	4.8
Ovary	HEYA8	4.2
Ovary	HS571T	5.2
Ovary	IGROV1	4.3
Ovary	JHOC5	4.3
Ovary	JHOM1	4.1
Ovary	JHOM2B	4
Ovary	JHOS2	4.2
Ovary	JHOS4	4.6
Ovary	KURAMOCHI	4.5
Ovary	MCAS	4
Ovary	NIHOVCAR3	4.1
Ovary	OAW28	5.6
Ovary	OAW42	4.3
Ovary	OC314	5.1
Ovary	OC316	5
Ovary	ONCODG1	4.1
Ovary	OV56	4.5
Ovary	OV7	4
Ovary	OV90	4.5
Ovary	OVCAR4	4.6
Ovary	OVCAR8	5.1
Ovary	OVISE	4.4
Ovary	OVK18	4.8
Ovary	OVKATE	4.6
Ovary	OVMANA	4.2
Ovary	OVSAHO	4.1
Ovary	OVTOKO	3.9
Ovary	RMGI	4
Ovary	RMUGS	4.3
Ovary	SKOV3	4
Ovary	SNU119	5.2
Ovary	SNU840	3.9
Ovary	SNU8	4.3
Ovary	TOV112D	6.4
Ovary	TOV21G	4.1
Ovary	TYKNU	4.5
Pancreas	ASPC1	3.9
Pancreas	BXPC3	3.6
Pancreas	CAPAN1	3.9
Pancreas	CAPAN2	4.4
Pancreas	CFPAC1	4.1
Pancreas	DANG	4.1
Pancreas	HPAC	4.1
Pancreas	HPAFII	4.2
Pancreas	HS766T	3.9
Pancreas	HUPT3	4.3
Pancreas	HUPT4	3.9
Pancreas	KCIMOH1	3.9
Pancreas	KLM1	3.9
Pancreas	KP2	4.1
Pancreas	KP3	5.1
Pancreas	KP4	5.1
Pancreas	L33	5
Pancreas	MIAPACA2	5.4
Pancreas	PANC0203	4.4
Pancreas	PANC0213	4.1
Pancreas	PANC0327	4
Pancreas	PANC0403	4
Pancreas	PANC0504	4.1
Pancreas	PANC0813	3.8
Pancreas	PANC1005	4.2
Pancreas	PANC1	4.3
Pancreas	PATU8902	3.9
Pancreas	PATU8988S	4
Pancreas	PATU8988T	3.9
Pancreas	PK1	4
Pancreas	PK45H	4.2
Pancreas	PK59	4.7
Pancreas	PL45	4.2
Pancreas	PSN1	4.2
Pancreas	QGP1	4.4
Pancreas	SNU213	4.1
Pancreas	SNU324	4.3
Pancreas	SNU410	4.2
Pancreas	SU8686	4.1
Pancreas	SUIT2	3.9
Pancreas	SW1990	3.8
Pancreas	T3M4	4.1
Pancreas	TCCPAN2	4.8
Pancreas	YAPC	4.3
Pleura	ACCMESO1	4.2
Pleura	DM3	4.1
Pleura	ISTMES1	4.3
Pleura	ISTMES2	4
Pleura	JL1	3.9
Pleura	MPP89	4.2
Pleura	MSTO211H	4.6
Pleura	NCIH2052	4
Pleura	NCIH2452	4.1
Pleura	NCIH28	3.9
Prostate	22RV1	4.7
Prostate	DU145	4.5
Prostate	LNCAPCLONEFGC	4.3
Prostate	MDAPCA2B	4.5
Prostate	NCIH660	4.2
Prostate	PC3	4.3
Prostate	VCAP	4.1
Salivary gland	A253	4.3
Salivary gland	YD15	4.1
Skin	A101D	4.4
Skin	A2058	4.2
Skin	A375	4.5
Skin	C32	4.1
Skin	CHL1	4.3
Skin	CJM	3.9
Skin	COLO679	4.2
Skin	COLO741	4.1
Skin	COLO783	4.6
Skin	COLO792	4.9
Skin	COLO800	4.1
Skin	COLO818	4.2
Skin	COLO829	4.6
Skin	COLO849	4.1
Skin	G361	4.1
Skin	GRM	4.1
Skin	HMCB	3.9
Skin	HS294T	4.4
Skin	HS600T	4.2
Skin	HS688AT	4.3
Skin	HS695T	4.2
Skin	HS839T	4.1
Skin	HS852T	4.7
Skin	HS895T	4.3
Skin	HS934T	4
Skin	HS936T	4.4
Skin	HS939T	4.4
Skin	HS940T	4.4
Skin	HS944T	4.2
Skin	HT144	4.3
Skin	IGR1	4.5
Skin	IGR37	3.7
Skin	IGR39	4.2
Skin	IPC298	4.4
Skin	K029AX	4.3
Skin	LOXIMVI	4.6
Skin	MALME3M	4
Skin	MDAMB435S	4.4
Skin	MELHO	4
Skin	MELJUSO	3.9
Skin	MEWO	4.2
Skin	RPMI7951	4.6
Skin	RVH421	4.3
Skin	SH4	4.3
Skin	SKMEL1	4.6
Skin	SKMEL24	4.1
Skin	SKMEL28	4.2
Skin	SKMEL2	4.3
Skin	SKMEL30	4.1
Skin	SKMEL31	4.2
Skin	SKMEL3	4.8
Skin	SKMEL5	4.3
Skin	UACC257	3.9
Skin	UACC62	4.7
Skin	WM115	4.8
Skin	WM1799	4.1
Skin	WM2664	4.1
Skin	WM793	4.3
Skin	WM88	4.7
Skin	WM983B	4.4
Small intestine	HUTU80	5.8
Soft tissue	A204	4
Soft tissue	G401	4.6
Soft tissue	G402	5.5
Soft tissue	GCT	4
Soft tissue	HS729	4.7
Soft tissue	HT1080	3.9
Soft tissue	KYM1	4.4
Soft tissue	MESSA	4.5
Soft tissue	RD	5.3
Soft tissue	RH30	5.2
Soft tissue	RH41	5.8
Soft tissue	RKN	4.5
Soft tissue	S117	4.2
Soft tissue	SJRH30	5.7
Soft tissue	SKLMS1	4.8
Soft tissue	SKUT1	5.6
Soft tissue	TE125T	4.4
Soft tissue	TE159T	4.3
Soft tissue	TE441T	4.6
Soft tissue	TE617T	4.6
Stomach	2313287	4
Stomach	AGS	4.4
Stomach	AZ521	5.6
Stomach	ECC10	4.1
Stomach	ECC12	4.6
Stomach	FU97	4.9
Stomach	GCIY	5.4
Stomach	GSS	4.8
Stomach	GSU	4.1
Stomach	HGC27	5
Stomach	HS746T	5.7
Stomach	HUG1N	4.1
Stomach	IM95	3.9
Stomach	KATOIII	3.8
Stomach	KE39	9.5
Stomach	LMSU	4.1
Stomach	MKN1	4.8
Stomach	MKN45	4.4
Stomach	MKN74	6.2
Stomach	MKN7	5.1
Stomach	NCCSTCK140	5
Stomach	NCIN87	4
Stomach	NUGC2	4.7
Stomach	NUGC3	4.1
Stomach	NUGC4	4
Stomach	OCUM1	4.1
Stomach	RERFGC1B	5.1
Stomach	SH10TC	5
Stomach	SNU16	4.5
Stomach	SNU1	4.7
Stomach	SNU216	3.9
Stomach	SNU520	4.6
Stomach	SNU5	4.3
Stomach	SNU601	4.1
Stomach	SNU620	5
Stomach	SNU668	3.9
Stomach	SNU719	4.5
Stomach	TGBC11TKB	5.9
Thyroid	8305C	4
Thyroid	8505C	3.9
Thyroid	BCPAP	5.2
Thyroid	BHT101	4
Thyroid	CAL62	3.9
Thyroid	CGTHW1	4.9
Thyroid	FTC133	4.2
Thyroid	FTC238	4.4
Thyroid	ML1	4.3
Thyroid	SW579	4.5
Thyroid	TT2609C02	4.3
Thyroid	TT	4.2
Upper aerodigestive tract	BHY	3.8
Upper aerodigestive tract	BICR16	4.5
Upper aerodigestive tract	BICR18	4.8
Upper aerodigestive tract	BICR22	4.2
Upper aerodigestive tract	BICR31	4
Upper aerodigestive tract	BICR56	4.3
Upper aerodigestive tract	BICR6	4.1
Upper aerodigestive tract	CAL27	4.3
Upper aerodigestive tract	CAL33	3.7
Upper aerodigestive tract	DETROIT562	3.9
Upper aerodigestive tract	FADU	3.9
Upper aerodigestive tract	HS840T	4.4
Upper aerodigestive tract	HSC2	4
Upper aerodigestive tract	HSC3	4
Upper aerodigestive tract	HSC4	5
Upper aerodigestive tract	PECAPJ15	4.4
Upper aerodigestive tract	PECAPJ34CLONEC12	4.1
Upper aerodigestive tract	PECAPJ41CLONED2	3.9
Upper aerodigestive tract	PECAPJ49	5
Upper aerodigestive tract	SCC15	4.3
Upper aerodigestive tract	SCC25	4.2
Upper aerodigestive tract	SCC4	3.8
Upper aerodigestive tract	SCC9	3.9
Upper aerodigestive tract	SNU1076	4.3
Upper aerodigestive tract	SNU1214	4.6
Upper aerodigestive tract	SNU46	4.3
Upper aerodigestive tract	SNU899	3.8
Upper aerodigestive tract	YD10B	4.2
Upper aerodigestive tract	YD38	3.9
Upper aerodigestive tract	YD8	5
Urinary tract	5637	5.7
Urinary tract	639V	4.4
Urinary tract	647V	4.1
Urinary tract	BC3C	4
Urinary tract	BFTC905	3.9
Urinary tract	CAL29	3.8
Urinary tract	HS172T	4.6
Urinary tract	HT1197	4.3
Urinary tract	HT1376	4.2
Urinary tract	J82	4.2
Urinary tract	JMSU1	5.3
Urinary tract	KMBC2	4
Urinary tract	KU1919	4.2
Urinary tract	RT11284	4
Urinary tract	RT112	4.2
Urinary tract	RT4	3.8
Urinary tract	SCABER	4
Urinary tract	SW1710	4.3
Urinary tract	SW780	4
Urinary tract	T24	4
Urinary tract	TCCSUP	4.7
Urinary tract	UMUC1	4.1
Urinary tract	UMUC3	4.5
Urinary tract	VMCUB1	4.2

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0.9
Adrenal gland	3.6
Appendix	1.4
Bone marrow	0.1
Breast	1.4
Cerebral cortex	2.5
Cervix, uterine	1.6
Colon	1.1
Duodenum	3.6
Endometrium	2.7
Epididymis	1.4
Esophagus	1.6
Fallopian tube	2.4
Gallbladder	1.9
Heart muscle	2.8
Kidney	3.4
Liver	1.7
Lung	2.4
Lymph node	1.6
Ovary	3.1
Pancreas	0.4
Parathyroid gland	3.5
Placenta	1.3
Prostate	2
Rectum	1.2
Salivary gland	1.2
Seminal vesicle	2
Skeletal muscle	3.3
Skin	3.7
Small intestine	1.6
Smooth muscle	2.7
Spleen	1.5
Stomach	1.3
Testis	9.5
Thyroid gland	3.1
Tonsil	1
Urinary bladder	1.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27698834	Overexpression	Breast Carcinoma	SIRT4 protein was markedly increased in the breast cancer cells compared with adjacent non-tumor mammary cells and was correlated with estrogen receptor, progesterone receptor, nuclear-associated antigen Ki-67 and tumor protein p53 status, as well as breast cancer subtypes.
27080717	Underexpression	Breast Carcinoma	Particularly, expressions of SIRT1 and SIRT4 were found to be significantly down-regulated in breast cancer tissues and SKBR3 breast cancer cells.
26986234	Underexpression	Colorectal Carcinoma	Using a tissue microarray of 89 colorectal cancer cases, we found that SIRT4 was significantly downregulated in colorectal cancer tissues compared with that noted in the corresponding normal tissue (P<0.001).
26785117	Underexpression	Head and Neck Squamous Cell Carcinoma	A statistically significant downregulation of SIRT3 (p<0.001), SIRT4 (p<0.0001), MTUS1 (p<0.002) and OGG1 (p<0.0001) was observed in HNSCC compared to control samples.
26054687	Underexpression	Gastric Adenocarcinoma	We found that the expression level of SIRT4 in gastric adenocarcinoma was significantly lower than the corresponding normal tissue levels (P=0.003).
28582846	Underexpression	Endometrioid Adenocarcinoma	SIRT4 protein levels in endometrioid adenocarcinoma were markedly lower than its non-neoplastic tissue counterpart (P< 0.001).
27941873	Underexpression	Non-Small Cell Lung Carcinoma	We demonstrated that SIRT4 was decreased in 70 out of 133 non-small cell lung cancer (NSCLC) cases by immunohistochemical staining and localized in the mitochondria using confocal microscopy.

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.074	0.138	17.1	58.7	24.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.235	5.5e-15	19.3	62.9	17.8	Neutral
CESC	Cervical and endocervical cancers	292	0.181	0.00193	7.9	76	16.1	Neutral
COAD	Colon adenocarcinoma	449	0.13	0.00588	12.2	68.2	19.6	Neutral
ESCA	Esophageal carcinoma	183	0.342	2.22e-06	23	54.6	22.4	Neutral
GBM	Glioblastoma multiforme	147	0.138	0.0953	8.8	82.3	8.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.064	0.149	10.3	73.7	16	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.113	0.00971	1.1	75.8	23	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.395	3.32e-12	0	60.1	39.9	Gain
LAML	Acute Myeloid Leukemia	166	-0.098	0.21	0.6	99.4	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.228	1.68e-07	10.7	85.2	4.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.241	3.45e-06	13.5	73.6	12.9	Neutral
LUAD	Lung adenocarcinoma	512	0.202	4.25e-06	24	51.8	24.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.188	2.46e-05	16.7	58.8	24.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.464	1.97e-17	29	40	31	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.4	3.33e-08	22	68.4	9.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.122	0.122	1.9	89.5	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.152	0.000738	5.5	88	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.309	5.75e-05	13.4	72	14.6	Neutral
SARC	Sarcoma	255	0.435	3.17e-13	23.9	56.5	19.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.219	2.29e-05	22.9	67.6	9.5	Neutral
STAD	Stomach adenocarcinoma	413	0.155	0.00157	12.3	65.1	22.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.169	0.0386	1.3	42.7	56	Gain
THCA	Thyroid carcinoma	497	0.229	2.48e-07	0	97	3	Neutral
THYM	Thymoma	119	0.009	0.922	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.216	4.36e-07	11.2	77.8	11	Neutral

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.054	0.269	17	408	-0.007	0.0263	NS/NA
BRCA	Breast invasive carcinoma	-0.108	0.00145	83	785	-0.013	0.0323	NS/NA
CESC	Cervical and endocervical cancers	-0.095	0.0942	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.026	0.65	19	297	0.009	0.000109	NS/NA
ESCA	Esophageal carcinoma	-0.214	0.00274	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.177	0.158	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.093	0.0304	20	522	-0.002	0.437	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.196	0.000269	24	319	0.004	9.13e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.221	0.000121	23	275	0.008	0.000967	NS/NA
LAML	Acute Myeloid Leukemia	-0.019	0.806	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.07	0.106	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.047	0.337	41	373	-0.004	0.0259	NS/NA
LUAD	Lung adenocarcinoma	-0.134	0.00328	21	456	-0.014	0.195	NS/NA
LUSC	Lung squamous cell carcinoma	-0.2	9.36e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.433	0.25	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.141	0.0569	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.173	0.0179	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.054	0.216	35	498	-0.005	0.000702	NS/NA
READ	Rectum adenocarcinoma	-0.086	0.389	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.208	0.000688	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.082	0.0735	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.098	0.0587	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	0.07	0.382	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.047	0.266	50	509	-0.025	0.012	NS/NA
THYM	Thymoma	-0.588	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.136	0.00344	34	431	-0.001	0.278	NS/NA

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	1	Low
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	1	Low
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	1	Low
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	1	Low
Kidney	2	Medium
Liver	2	Medium
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	1	Low
Parathyroid gland	1	Low
Placenta	3	High
Prostate	1	Low
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	1	Low
Skeletal muscle	2	Medium
Skin	0	Not detected
Small intestine	1	Low
Smooth muscle	2	Medium
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	1	Low
Tonsil	1	Low
Urinary bladder	1	Low
Vagina	0	Not detected

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0364	Significant	24476821
BRCA	Breast invasive carcinoma	521	0.00108	Significant	23000897
COAD	Colon adenocarcinoma	149	0.646	NS	22810696
GBM	Glioblastoma multiforme	157	0.000212	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0583	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.945	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.52e-13	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0015	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.94e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00315	Significant	21720365
PRAD	Prostate adenocarcinoma	333	9.9e-11	Significant	26544944
READ	Rectum adenocarcinoma	67	0.469	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.606	NS	26091043
STAD	Stomach adenocarcinoma	277	4.01e-05	Significant	25079317
THCA	Thyroid carcinoma	391	2.09e-40	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00689	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.268	0.258	NS
BRCA	Breast invasive carcinoma	1079	1.204	0.414	NS
CESC	Cervical and endocervical cancers	291	0.82	0.547	NS
COAD	Colon adenocarcinoma	439	1.099	0.727	NS
ESCA	Esophageal carcinoma	184	0.807	0.511	NS
GBM	Glioblastoma multiforme	158	0.874	0.606	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.174	0.392	NS
KIRC	Kidney renal clear cell carcinoma	531	0.747	0.178	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.519	0.147	NS
LAML	Acute Myeloid Leukemia	149	0.708	0.277	NS
LGG	Brain Lower Grade Glioma	511	0.601	0.0381	Longer
LIHC	Liver hepatocellular carcinoma	365	1.249	0.356	NS
LUAD	Lung adenocarcinoma	502	0.785	0.257	NS
LUSC	Lung squamous cell carcinoma	494	1.005	0.978	NS
OV	Ovarian serous cystadenocarcinoma	303	1.022	0.914	NS
PAAD	Pancreatic adenocarcinoma	177	0.698	0.257	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.547	0.613	NS
PRAD	Prostate adenocarcinoma	497	0.749	0.707	NS
READ	Rectum adenocarcinoma	159	4.151	0.0217	Shorter
SARC	Sarcoma	259	0.764	0.342	NS
SKCM	Skin Cutaneous Melanoma	459	0.932	0.702	NS
STAD	Stomach adenocarcinoma	388	1.052	0.82	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.297	NS
THCA	Thyroid carcinoma	500	0.735	0.625	NS
THYM	Thymoma	119	0.665	0.629	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.184	0.573	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.067	0.176	NS
BRCA	Breast invasive carcinoma	1071	0.022	0.469	NS
CESC	Cervical and endocervical cancers	167	0.153	0.048	Higher
COAD	Colon adenocarcinoma	445	-0.013	0.777	NS
ESCA	Esophageal carcinoma	162	0.126	0.111	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.052	0.276	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.05	0.247	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.002	0.977	NS
LIHC	Liver hepatocellular carcinoma	347	-0.037	0.49	NS
LUAD	Lung adenocarcinoma	507	-0.046	0.299	NS
LUSC	Lung squamous cell carcinoma	497	0.115	0.0102	Higher
OV	Ovarian serous cystadenocarcinoma	302	0.005	0.927	NS
PAAD	Pancreatic adenocarcinoma	176	-0.1	0.186	NS
READ	Rectum adenocarcinoma	156	-0.005	0.947	NS
SKCM	Skin Cutaneous Melanoma	410	0.041	0.412	NS
STAD	Stomach adenocarcinoma	392	-0.08	0.113	NS
TGCT	Testicular Germ Cell Tumors	81	0.241	0.03	Higher
THCA	Thyroid carcinoma	499	-0.095	0.0334	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.008	0.857	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.002	0.968	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.074	0.0998	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.035	0.422	NS
LGG	Brain Lower Grade Glioma	514	0.032	0.468	NS
LIHC	Liver hepatocellular carcinoma	366	-0.007	0.894	NS
OV	Ovarian serous cystadenocarcinoma	296	0.071	0.225	NS
PAAD	Pancreatic adenocarcinoma	176	-0.069	0.366	NS
STAD	Stomach adenocarcinoma	406	0.019	0.708	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.054	0.217	NS

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SIRT4.

Summary
Symbol	SIRT4
Name	sirtuin 4
Aliases	SIR2L4; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin (silent mat ......
Location	12q24.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27698834	Breast Carcinoma	partner	Ki-67; p53	correlation	SIRT4 protein was markedly increased in the breast cancer cells compared with adjacent non-tumor mammary cells and was correlated with estrogen receptor, progesterone receptor, nuclear-associated antigen Ki-67 and tumor protein p53 status, as well as breast cancer subtypes.
26785117	Head and Neck Squamous Cell Carcinoma	partner	SIRT3; OGG1	Positive correlation	Additionally, to explore gene-gene relationship, we observed a positive spearmen correlation between SIRT3 versus SIRT4 (r = 0.523*, p<0.0001), SIRT3 versus MTUS1 (r = 0.273, p<0.001), SIRT3 versus OGG1-2a (r = 0.213, p<0.03), SIRT4 versus OGG1 (r = 0.338**, p<0.0001) and MTUS1 versus OGG1-2a (r = 0.215, p<0.03) in HNSCC cases.
27941873	Non-Small Cell Lung Carcinoma	partner	Fis-1	Binding	SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.
27941873	Non-Small Cell Lung Carcinoma	downstream	Drp1; MEK/ERK	Regulation; negative regulation	SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1. SIRT4 expression was lower in nodal metastatic tumor samples than their corresponding primary tumors, and cases with low expression of SIRT4 tended to have high p-Drp1 labeling. Also, MEK/ERK activity appeared to be hampered by SIRT4 expression, which may have implications for cells' invasive capacities.