CR2Cancer

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02146 Sir2 family

Function

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H3K9ac, H3K56ac	H3K9, H3K56	18337721

> Gene Ontology [ TOP ]
Biological Process	GO:0000018 regulation of DNA recombination GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0003007 heart morphogenesis GO:0003241 growth involved in heart morphogenesis GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006109 regulation of carbohydrate metabolic process GO:0006110 regulation of glycolytic process GO:0006140 regulation of nucleotide metabolic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006282 regulation of DNA repair GO:0006284 base-excision repair GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0006471 protein ADP-ribosylation GO:0006476 protein deacetylation GO:0006486 protein glycosylation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006757 ATP generation from ADP GO:0007507 heart development GO:0007517 muscle organ development GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009116 nucleoside metabolic process GO:0009118 regulation of nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010569 regulation of double-strand break repair via homologous recombination GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010827 regulation of glucose transport GO:0010829 negative regulation of glucose transport GO:0014706 striated muscle tissue development GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0016049 cell growth GO:0016052 carbohydrate catabolic process GO:0016570 histone modification GO:0016575 histone deacetylation GO:0019362 pyridine nucleotide metabolic process GO:0031647 regulation of protein stability GO:0031648 protein destabilization GO:0031667 response to nutrient levels GO:0033500 carbohydrate homeostasis GO:0035265 organ growth GO:0035601 protein deacylation GO:0042278 purine nucleoside metabolic process GO:0042326 negative regulation of phosphorylation GO:0042593 glucose homeostasis GO:0043413 macromolecule glycosylation GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045820 negative regulation of glycolytic process GO:0045912 negative regulation of carbohydrate metabolic process GO:0045978 negative regulation of nucleoside metabolic process GO:0045980 negative regulation of nucleotide metabolic process GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046325 negative regulation of glucose import GO:0046496 nicotinamide nucleotide metabolic process GO:0046939 nucleotide phosphorylation GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048588 developmental cell growth GO:0048644 muscle organ morphogenesis GO:0048738 cardiac muscle tissue development GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051186 cofactor metabolic process GO:0051193 regulation of cofactor metabolic process GO:0051195 negative regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0051198 negative regulation of coenzyme metabolic process GO:0055008 cardiac muscle tissue morphogenesis GO:0055017 cardiac muscle tissue growth GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060537 muscle tissue development GO:0060560 developmental growth involved in morphogenesis GO:0061647 histone H3-K9 modification GO:0070085 glycosylation GO:0070932 histone H3 deacetylation GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072524 pyridine-containing compound metabolic process GO:0098732 macromolecule deacylation GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1901657 glycosyl compound metabolic process GO:1903578 regulation of ATP metabolic process GO:1903579 negative regulation of ATP metabolic process GO:1990619 histone H3-K9 deacetylation GO:2000648 positive regulation of stem cell proliferation GO:2000779 regulation of double-strand break repair GO:2001020 regulation of response to DNA damage stimulus
Molecular Function	GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity GO:0004407 histone deacetylase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016763 transferase activity, transferring pentosyl groups GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0032129 histone deacetylase activity (H3-K9 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0070403 NAD+ binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0005720 nuclear heterochromatin GO:0005724 nuclear telomeric heterochromatin GO:0031933 telomeric heterochromatin GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693538: Homology Directed Repair R-HSA-5693607: Processing of DNA double-strand break ends

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM21739	c.23G>A	p.G8E	Substitution - Missense	Skin
COSM1225799	c.246C>A	p.F82L	Substitution - Missense	Large_intestine
COSM5389846	c.489C>T	p.G163G	Substitution - coding silent	Skin
COSM5582501	c.327C>T	p.F109F	Substitution - coding silent	Skin
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM5972968	c.583C>T	p.R195W	Substitution - Missense	Upper_aerodigestive_tract
COSM3534381	c.79C>T	p.P27S	Substitution - Missense	Skin
COSM5499342	c.692G>A	p.R231H	Substitution - Missense	Biliary_tract
COSM3823169	c.964C>T	p.Q322*	Substitution - Nonsense	Breast
COSM712797	c.778G>T	p.E260*	Substitution - Nonsense	Lung
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM3226828	c.590T>C	p.L197P	Substitution - Missense	Large_intestine
COSM5782236	c.234G>A	p.L78L	Substitution - coding silent	Breast
COSM21739	c.23G>A	p.G8E	Substitution - Missense	Skin
COSM4748996	c.242A>G	p.K81R	Substitution - Missense	Stomach
COSM4627690	c.741C>T	p.D247D	Substitution - coding silent	Large_intestine
COSM5365199	c.307C>T	p.R103C	Substitution - Missense	Large_intestine
COSM3534350	c.870C>T	p.P290P	Substitution - coding silent	Skin
COSM355800	c.243G>T	p.K81N	Substitution - Missense	Lung
COSM4131895	c.311T>A	p.V104E	Substitution - Missense	Thyroid
COSM5365199	c.307C>T	p.R103C	Substitution - Missense	Large_intestine
COSM3692782	c.924C>G	p.N308K	Substitution - Missense	Soft_tissue
COSM5659549	c.715G>T	p.V239F	Substitution - Missense	Soft_tissue
COSM303208	c.404delA	p.N135fs*25	Deletion - Frameshift	Central_nervous_system
COSM3701500	c.362G>T	p.R121L	Substitution - Missense	Liver
COSM4431664	c.365C>G	p.S122*	Substitution - Nonsense	Oesophagus
COSM1750838	c.367G>T	p.G123C	Substitution - Missense	Urinary_tract
COSM474779	c.107A>T	p.E36V	Substitution - Missense	Kidney
COSM5800137	c.441G>A	p.Q147Q	Substitution - coding silent	Breast
COSM4836850	c.787A>C	p.T263P	Substitution - Missense	Cervix
COSM5389845	c.939C>T	p.A313A	Substitution - coding silent	Skin
COSM712793	c.346G>A	p.D116N	Substitution - Missense	Lung
COSM4646606	c.712A>G	p.I238V	Substitution - Missense	Large_intestine
COSM3226914	c.194+7G>A	p.?	Unknown	Pancreas
COSM1325311	c.1002G>A	p.E334E	Substitution - coding silent	Ovary
COSM4777421	c.448C>T	p.R150*	Substitution - Nonsense	Breast
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM4921291	c.325T>C	p.F109L	Substitution - Missense	Liver
COSM3692782	c.924C>G	p.N308K	Substitution - Missense	Large_intestine
COSM3933052	c.752A>C	p.D251A	Substitution - Missense	Urinary_tract
COSM3692780	c.956C>T	p.P319L	Substitution - Missense	Large_intestine
COSM712792	c.265G>T	p.A89S	Substitution - Missense	Lung
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM4534206	c.205G>A	p.G69R	Substitution - Missense	Skin
COSM4627687	c.1059C>T	p.V353V	Substitution - coding silent	Large_intestine
COSM1750838	c.367G>T	p.G123C	Substitution - Missense	Urinary_tract
COSM5565422	c.872G>C	p.R291P	Substitution - Missense	Prostate
COSM3892651	c.72C>T	p.F24F	Substitution - coding silent	Skin
COSM5565422	c.872G>C	p.R291P	Substitution - Missense	Gastrointestinal_tract_(site_indeterminate)
COSM1644987	c.80C>G	p.P27R	Substitution - Missense	Salivary_gland
COSM5770369	c.299A>G	p.Q100R	Substitution - Missense	Breast
COSM4972182	c.275C>T	p.T92M	Substitution - Missense	Thyroid
COSM3226812	c.757C>T	p.R253C	Substitution - Missense	Large_intestine
COSM392901	c.73G>A	p.D25N	Substitution - Missense	Lung
COSM1644987	c.80C>G	p.P27R	Substitution - Missense	Upper_aerodigestive_tract
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM4590338	c.671A>C	p.N224T	Substitution - Missense	Upper_aerodigestive_tract
COSM3692781	c.937G>T	p.A313S	Substitution - Missense	Large_intestine
COSM1393037	c.483C>T	p.A161A	Substitution - coding silent	Large_intestine
COSM4505872	c.703C>T	p.R235C	Substitution - Missense	Skin
COSM118310	c.789C>T	p.T263T	Substitution - coding silent	Ovary
COSM5770369	c.299A>G	p.Q100R	Substitution - Missense	Breast
COSM21739	c.23G>A	p.G8E	Substitution - Missense	Skin
COSM4930769	c.664A>T	p.S222C	Substitution - Missense	Liver
COSM1287937	c.15C>T	p.Y5Y	Substitution - coding silent	Autonomic_ganglia
COSM4627687	c.1059C>T	p.V353V	Substitution - coding silent	Large_intestine
COSM5364732	c.739-7delT	p.?	Unknown	Large_intestine
COSM5483053	c.67-10C>T	p.?	Unknown	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for SIRT6.

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8N6T7	10	S	Phosphoserine	-	No	None detected
Q8N6T7	294	T	Phosphothreonine	-	No	None detected
Q8N6T7	303	S	Phosphoserine	-	No	None detected
Q8N6T7	330	S	Phosphoserine	-	No	None detected

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.843	4.558	0.76	6.47e-07	Over
BRCA	Breast invasive carcinoma	112	1100	2.851	3.72	0.974	8.51e-40	Over
CESC	Cervical and endocervical cancers	3	306	3.882	4.338	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.815	4.924	-0.824	8.97e-14	Under
ESCA	Esophageal carcinoma	11	185	3.454	3.967	0.639	0.00183	Over
GBM	Glioblastoma multiforme	5	166	3.733	4.334	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.76	4.07	0.382	0.000138	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.343	3.706	0.438	2.1e-08	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.981	4.562	0.674	1.01e-08	Over
LAML	Acute Myeloid Leukemia	0	173	NA	3.414	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.311	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.043	3.575	0.609	1.14e-08	Over
LUAD	Lung adenocarcinoma	59	517	3.592	3.942	0.352	1.39e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	3.567	3.956	0.414	1.33e-07	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.842	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.308	4.485	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.397	4.257	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.956	4.26	0.347	5.21e-05	NS
READ	Rectum adenocarcinoma	10	167	5.373	4.99	-0.514	0.0401	NS
SARC	Sarcoma	2	263	4.01	4.442	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.216	4.319	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.391	4.169	0.038	0.8	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.391	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.649	4.231	0.566	2.27e-14	NS
THYM	Thymoma	2	120	4.279	4.875	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.081	4.878	0.709	1.3e-09	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.2
Autonomic ganglia	CHP212	5.8
Autonomic ganglia	IMR32	5.9
Autonomic ganglia	KELLY	5.8
Autonomic ganglia	KPNRTBM1	5.9
Autonomic ganglia	KPNSI9S	5.8
Autonomic ganglia	KPNYN	6
Autonomic ganglia	MHHNB11	6.3
Autonomic ganglia	NB1	6
Autonomic ganglia	NH6	5.9
Autonomic ganglia	SHSY5Y	5.7
Autonomic ganglia	SIMA	5.8
Autonomic ganglia	SKNAS	6.1
Autonomic ganglia	SKNBE2	6.2
Autonomic ganglia	SKNDZ	6.1
Autonomic ganglia	SKNFI	6
Autonomic ganglia	SKNSH	5.7
Biliary tract	HUCCT1	6.2
Biliary tract	HUH28	6
Biliary tract	SNU1079	6.2
Biliary tract	SNU1196	6.1
Biliary tract	SNU245	5.7
Biliary tract	SNU308	6.4
Biliary tract	SNU478	6.2
Bone	143B	6.2
Bone	A673	6
Bone	CADOES1	6.2
Bone	CAL78	6.2
Bone	G292CLONEA141B1	6.3
Bone	HOS	6
Bone	HS706T	5.9
Bone	HS737T	6
Bone	HS819T	6.1
Bone	HS821T	6
Bone	HS822T	6.1
Bone	HS863T	6.1
Bone	HS870T	6.3
Bone	HS888T	6
Bone	MG63	5.6
Bone	MHHES1	5.7
Bone	OUMS27	5.9
Bone	RDES	5.7
Bone	SJSA1	6.2
Bone	SKES1	5.9
Bone	SKNMC	6
Bone	SW1353	6
Bone	T173	5.8
Bone	TC71	6.5
Bone	U2OS	5.6
Breast	AU565	5.8
Breast	BT20	5.9
Breast	BT474	5.8
Breast	BT483	6
Breast	BT549	6.3
Breast	CAL120	6
Breast	CAL148	6.2
Breast	CAL51	5.7
Breast	CAL851	6.3
Breast	CAMA1	6
Breast	DU4475	5.8
Breast	EFM192A	6.1
Breast	EFM19	6.1
Breast	EVSAT	6.2
Breast	HCC1143	5.7
Breast	HCC1187	5.7
Breast	HCC1395	6
Breast	HCC1419	6.1
Breast	HCC1428	6.2
Breast	HCC1500	5.9
Breast	HCC1569	5.7
Breast	HCC1599	5.6
Breast	HCC1806	6
Breast	HCC1937	5.4
Breast	HCC1954	5.7
Breast	HCC202	6.2
Breast	HCC2157	6.1
Breast	HCC2218	6.1
Breast	HCC38	5.9
Breast	HCC70	5.5
Breast	HDQP1	5.6
Breast	HMC18	6.2
Breast	HS274T	6
Breast	HS281T	6
Breast	HS343T	6.1
Breast	HS578T	6.2
Breast	HS606T	5.9
Breast	HS739T	6.1
Breast	HS742T	6.1
Breast	JIMT1	6
Breast	KPL1	6.2
Breast	MCF7	6.4
Breast	MDAMB134VI	6.2
Breast	MDAMB157	5.7
Breast	MDAMB175VII	6
Breast	MDAMB231	6.2
Breast	MDAMB361	5.9
Breast	MDAMB415	5.8
Breast	MDAMB436	6.1
Breast	MDAMB453	6.1
Breast	MDAMB468	6
Breast	SKBR3	5.7
Breast	T47D	5.8
Breast	UACC812	6
Breast	UACC893	5.8
Breast	YMB1	6
Breast	ZR751	5.7
Breast	ZR7530	6.1
Central nervous system	1321N1	6.4
Central nervous system	42MGBA	6.1
Central nervous system	8MGBA	5.7
Central nervous system	A172	6.5
Central nervous system	AM38	6.1
Central nervous system	BECKER	6.2
Central nervous system	CAS1	5.7
Central nervous system	CCFSTTG1	6.1
Central nervous system	D283MED	5.7
Central nervous system	D341MED	5.9
Central nervous system	DAOY	6.3
Central nervous system	DBTRG05MG	6
Central nervous system	DKMG	5.6
Central nervous system	GAMG	5.9
Central nervous system	GB1	6
Central nervous system	GI1	6.3
Central nervous system	GMS10	5.9
Central nervous system	GOS3	6.3
Central nervous system	H4	5.8
Central nervous system	HS683	5.8
Central nervous system	KALS1	6
Central nervous system	KG1C	5.9
Central nervous system	KNS42	6.1
Central nervous system	KNS60	6.2
Central nervous system	KNS81	5.9
Central nervous system	KS1	5.7
Central nervous system	LN18	6.1
Central nervous system	LN229	5.8
Central nervous system	M059K	6.1
Central nervous system	MOGGCCM	6
Central nervous system	MOGGUVW	6.1
Central nervous system	NMCG1	5.6
Central nervous system	ONS76	5.9
Central nervous system	SF126	6
Central nervous system	SF295	6.5
Central nervous system	SNB19	6
Central nervous system	SNU1105	6.2
Central nervous system	SNU201	5.9
Central nervous system	SNU466	6.5
Central nervous system	SNU489	6.2
Central nervous system	SNU626	5.9
Central nervous system	SNU738	6.1
Central nervous system	SW1088	6.1
Central nervous system	SW1783	5.9
Central nervous system	T98G	6
Central nervous system	TM31	5.5
Central nervous system	U118MG	6.5
Central nervous system	U138MG	5.9
Central nervous system	U251MG	5.9
Central nervous system	U87MG	6.6
Central nervous system	YH13	5.7
Central nervous system	YKG1	5.8
Endometrium	AN3CA	6.3
Endometrium	COLO684	6.1
Endometrium	EFE184	6.5
Endometrium	EN	6.2
Endometrium	ESS1	5.8
Endometrium	HEC108	6.1
Endometrium	HEC151	6.2
Endometrium	HEC1A	5.9
Endometrium	HEC1B	5.7
Endometrium	HEC251	5.8
Endometrium	HEC265	5.9
Endometrium	HEC50B	5.9
Endometrium	HEC59	5.6
Endometrium	HEC6	5.9
Endometrium	ISHIKAWAHERAKLIO02ER	5.7
Endometrium	JHUEM1	6.1
Endometrium	JHUEM2	5.9
Endometrium	JHUEM3	5.5
Endometrium	KLE	5.9
Endometrium	MFE280	5.9
Endometrium	MFE296	6.1
Endometrium	MFE319	6.3
Endometrium	RL952	6
Endometrium	SNGM	5.9
Endometrium	SNU1077	5.5
Endometrium	SNU685	5.7
Endometrium	TEN	6
Haematopoietic and lymphoid	697	6.3
Haematopoietic and lymphoid	A3KAW	6.3
Haematopoietic and lymphoid	A4FUK	6.3
Haematopoietic and lymphoid	ALLSIL	6.6
Haematopoietic and lymphoid	AML193	6.6
Haematopoietic and lymphoid	AMO1	6.4
Haematopoietic and lymphoid	BCP1	6.4
Haematopoietic and lymphoid	BDCM	6.4
Haematopoietic and lymphoid	BL41	6.7
Haematopoietic and lymphoid	BL70	6.7
Haematopoietic and lymphoid	BV173	6.2
Haematopoietic and lymphoid	CA46	7
Haematopoietic and lymphoid	CI1	7
Haematopoietic and lymphoid	CMK115	6
Haematopoietic and lymphoid	CMK86	5.8
Haematopoietic and lymphoid	CMK	6
Haematopoietic and lymphoid	CMLT1	6.2
Haematopoietic and lymphoid	COLO775	6
Haematopoietic and lymphoid	DAUDI	6.2
Haematopoietic and lymphoid	DB	7.1
Haematopoietic and lymphoid	DEL	6.2
Haematopoietic and lymphoid	DND41	6.9
Haematopoietic and lymphoid	DOHH2	6.7
Haematopoietic and lymphoid	EB1	6.7
Haematopoietic and lymphoid	EB2	7
Haematopoietic and lymphoid	EHEB	6.5
Haematopoietic and lymphoid	EJM	6.6
Haematopoietic and lymphoid	EM2	6.3
Haematopoietic and lymphoid	EOL1	6.7
Haematopoietic and lymphoid	F36P	7.1
Haematopoietic and lymphoid	GA10	6.4
Haematopoietic and lymphoid	GDM1	5.7
Haematopoietic and lymphoid	GRANTA519	6.7
Haematopoietic and lymphoid	HDLM2	6.7
Haematopoietic and lymphoid	HDMYZ	6
Haematopoietic and lymphoid	HEL9217	5.8
Haematopoietic and lymphoid	HEL	5.9
Haematopoietic and lymphoid	HH	6.4
Haematopoietic and lymphoid	HL60	6.7
Haematopoietic and lymphoid	HPBALL	6.7
Haematopoietic and lymphoid	HS604T	5.9
Haematopoietic and lymphoid	HS611T	6.4
Haematopoietic and lymphoid	HS616T	6.1
Haematopoietic and lymphoid	HS751T	5.6
Haematopoietic and lymphoid	HT	6.4
Haematopoietic and lymphoid	HTK	6.4
Haematopoietic and lymphoid	HUNS1	6.6
Haematopoietic and lymphoid	HUT102	6.3
Haematopoietic and lymphoid	HUT78	6.7
Haematopoietic and lymphoid	JEKO1	7
Haematopoietic and lymphoid	JK1	6.1
Haematopoietic and lymphoid	JM1	6.2
Haematopoietic and lymphoid	JURKAT	6
Haematopoietic and lymphoid	JURLMK1	6.3
Haematopoietic and lymphoid	JVM2	6.4
Haematopoietic and lymphoid	JVM3	6.4
Haematopoietic and lymphoid	K562	6.2
Haematopoietic and lymphoid	KARPAS299	6
Haematopoietic and lymphoid	KARPAS422	6.8
Haematopoietic and lymphoid	KARPAS620	6.1
Haematopoietic and lymphoid	KASUMI1	5.7
Haematopoietic and lymphoid	KASUMI2	6
Haematopoietic and lymphoid	KASUMI6	6.2
Haematopoietic and lymphoid	KCL22	6.1
Haematopoietic and lymphoid	KE37	6.2
Haematopoietic and lymphoid	KE97	6.8
Haematopoietic and lymphoid	KG1	6
Haematopoietic and lymphoid	KHM1B	6.7
Haematopoietic and lymphoid	KIJK	6.5
Haematopoietic and lymphoid	KMH2	6.5
Haematopoietic and lymphoid	KMM1	6.4
Haematopoietic and lymphoid	KMS11	6
Haematopoietic and lymphoid	KMS12BM	6.1
Haematopoietic and lymphoid	KMS18	6.4
Haematopoietic and lymphoid	KMS20	6.3
Haematopoietic and lymphoid	KMS21BM	6.4
Haematopoietic and lymphoid	KMS26	6.3
Haematopoietic and lymphoid	KMS27	6.9
Haematopoietic and lymphoid	KMS28BM	6.3
Haematopoietic and lymphoid	KMS34	6.4
Haematopoietic and lymphoid	KO52	5.8
Haematopoietic and lymphoid	KOPN8	7.3
Haematopoietic and lymphoid	KU812	6.1
Haematopoietic and lymphoid	KYO1	6.7
Haematopoietic and lymphoid	L1236	6.5
Haematopoietic and lymphoid	L363	7.4
Haematopoietic and lymphoid	L428	6.7
Haematopoietic and lymphoid	L540	7
Haematopoietic and lymphoid	LAMA84	6.1
Haematopoietic and lymphoid	LOUCY	6.1
Haematopoietic and lymphoid	LP1	6.6
Haematopoietic and lymphoid	M07E	6.2
Haematopoietic and lymphoid	MC116	6.9
Haematopoietic and lymphoid	ME1	6.7
Haematopoietic and lymphoid	MEC1	6.3
Haematopoietic and lymphoid	MEC2	6.9
Haematopoietic and lymphoid	MEG01	5.9
Haematopoietic and lymphoid	MHHCALL2	5.9
Haematopoietic and lymphoid	MHHCALL3	6.2
Haematopoietic and lymphoid	MHHCALL4	6.3
Haematopoietic and lymphoid	MINO	6.5
Haematopoietic and lymphoid	MJ	6.4
Haematopoietic and lymphoid	MM1S	6.6
Haematopoietic and lymphoid	MOLM13	7
Haematopoietic and lymphoid	MOLM16	5.7
Haematopoietic and lymphoid	MOLM6	6.7
Haematopoietic and lymphoid	MOLP2	6.9
Haematopoietic and lymphoid	MOLP8	6
Haematopoietic and lymphoid	MOLT13	6.3
Haematopoietic and lymphoid	MOLT16	6
Haematopoietic and lymphoid	MOLT4	6.2
Haematopoietic and lymphoid	MONOMAC1	6.2
Haematopoietic and lymphoid	MONOMAC6	6.5
Haematopoietic and lymphoid	MOTN1	6.7
Haematopoietic and lymphoid	MUTZ5	6.5
Haematopoietic and lymphoid	MV411	7
Haematopoietic and lymphoid	NALM19	6.6
Haematopoietic and lymphoid	NALM1	6.1
Haematopoietic and lymphoid	NALM6	6.1
Haematopoietic and lymphoid	NAMALWA	6.2
Haematopoietic and lymphoid	NB4	5.9
Haematopoietic and lymphoid	NCIH929	7.2
Haematopoietic and lymphoid	NCO2	5.8
Haematopoietic and lymphoid	NOMO1	6.2
Haematopoietic and lymphoid	NUDHL1	6.8
Haematopoietic and lymphoid	NUDUL1	6.4
Haematopoietic and lymphoid	OCIAML2	6.3
Haematopoietic and lymphoid	OCIAML3	6.8
Haematopoietic and lymphoid	OCIAML5	6.4
Haematopoietic and lymphoid	OCILY10	6.8
Haematopoietic and lymphoid	OCILY19	6.4
Haematopoietic and lymphoid	OCILY3	6.4
Haematopoietic and lymphoid	OCIM1	5.7
Haematopoietic and lymphoid	OPM2	6.2
Haematopoietic and lymphoid	P12ICHIKAWA	6.3
Haematopoietic and lymphoid	P31FUJ	6.5
Haematopoietic and lymphoid	P3HR1	7
Haematopoietic and lymphoid	PCM6	7.6
Haematopoietic and lymphoid	PEER	6.4
Haematopoietic and lymphoid	PF382	6.4
Haematopoietic and lymphoid	PFEIFFER	6.3
Haematopoietic and lymphoid	PL21	6.4
Haematopoietic and lymphoid	RAJI	6.4
Haematopoietic and lymphoid	RCHACV	5.9
Haematopoietic and lymphoid	REC1	7.1
Haematopoietic and lymphoid	REH	6.5
Haematopoietic and lymphoid	RI1	6.3
Haematopoietic and lymphoid	RL	6.5
Haematopoietic and lymphoid	RPMI8226	6.2
Haematopoietic and lymphoid	RPMI8402	6.2
Haematopoietic and lymphoid	RS411	6.6
Haematopoietic and lymphoid	SEM	6.1
Haematopoietic and lymphoid	SET2	5.9
Haematopoietic and lymphoid	SIGM5	6.6
Haematopoietic and lymphoid	SKM1	6.2
Haematopoietic and lymphoid	SKMM2	6.2
Haematopoietic and lymphoid	SR786	6.7
Haematopoietic and lymphoid	ST486	6.2
Haematopoietic and lymphoid	SUDHL10	7
Haematopoietic and lymphoid	SUDHL1	6.4
Haematopoietic and lymphoid	SUDHL4	7.2
Haematopoietic and lymphoid	SUDHL5	7
Haematopoietic and lymphoid	SUDHL6	6.4
Haematopoietic and lymphoid	SUDHL8	6.7
Haematopoietic and lymphoid	SUPB15	6.1
Haematopoietic and lymphoid	SUPHD1	6.6
Haematopoietic and lymphoid	SUPM2	5.7
Haematopoietic and lymphoid	SUPT11	5.8
Haematopoietic and lymphoid	SUPT1	6.7
Haematopoietic and lymphoid	TALL1	6.7
Haematopoietic and lymphoid	TF1	6.1
Haematopoietic and lymphoid	THP1	6.1
Haematopoietic and lymphoid	TO175T	6.2
Haematopoietic and lymphoid	TOLEDO	6.2
Haematopoietic and lymphoid	U266B1	6.9
Haematopoietic and lymphoid	U937	6.6
Haematopoietic and lymphoid	UT7	6.3
Haematopoietic and lymphoid	WSUDLCL2	6.6
Kidney	769P	6.2
Kidney	786O	6.4
Kidney	A498	6.4
Kidney	A704	5.8
Kidney	ACHN	5.7
Kidney	BFTC909	5.9
Kidney	CAKI1	5.7
Kidney	CAKI2	6.7
Kidney	CAL54	5.9
Kidney	KMRC1	5.8
Kidney	KMRC20	5.4
Kidney	KMRC2	6.4
Kidney	KMRC3	6.1
Kidney	OSRC2	6
Kidney	RCC10RGB	6
Kidney	SNU1272	6.2
Kidney	SNU349	6
Kidney	TUHR10TKB	5.5
Kidney	TUHR14TKB	6.1
Kidney	TUHR4TKB	6.1
Kidney	VMRCRCW	6.2
Kidney	VMRCRCZ	5.9
Large intestine	C2BBE1	5.8
Large intestine	CCK81	6.3
Large intestine	CL11	6.1
Large intestine	CL14	6.7
Large intestine	CL34	6.3
Large intestine	CL40	7.3
Large intestine	COLO205	6.3
Large intestine	COLO320	6
Large intestine	COLO678	5.8
Large intestine	CW2	6.5
Large intestine	DLD1	6.3
Large intestine	GP2D	5.8
Large intestine	HCC56	6.7
Large intestine	HCT116	6.2
Large intestine	HCT15	6.2
Large intestine	HS675T	6
Large intestine	HS698T	6
Large intestine	HT115	6.3
Large intestine	HT29	6.2
Large intestine	HT55	6.4
Large intestine	KM12	6.3
Large intestine	LOVO	6
Large intestine	LS1034	6.5
Large intestine	LS123	6.2
Large intestine	LS180	6.4
Large intestine	LS411N	6
Large intestine	LS513	6
Large intestine	MDST8	6.4
Large intestine	NCIH508	6.4
Large intestine	NCIH716	6.2
Large intestine	NCIH747	6.5
Large intestine	OUMS23	5.9
Large intestine	RCM1	6.2
Large intestine	RKO	6.6
Large intestine	SKCO1	5.9
Large intestine	SNU1040	6.7
Large intestine	SNU1197	6.5
Large intestine	SNU175	6.5
Large intestine	SNU283	6.6
Large intestine	SNU407	6.2
Large intestine	SNU503	6.2
Large intestine	SNU61	6.5
Large intestine	SNU81	6.4
Large intestine	SNUC1	7
Large intestine	SNUC2A	5.8
Large intestine	SNUC4	6.5
Large intestine	SNUC5	6.1
Large intestine	SW1116	6.3
Large intestine	SW1417	6.4
Large intestine	SW1463	6.5
Large intestine	SW403	6.1
Large intestine	SW480	6.1
Large intestine	SW48	5.8
Large intestine	SW620	6.1
Large intestine	SW837	5.4
Large intestine	SW948	6.3
Large intestine	T84	6.4
Liver	ALEXANDERCELLS	5.9
Liver	C3A	5.7
Liver	HEP3B217	6.2
Liver	HEPG2	6.2
Liver	HLE	5.8
Liver	HLF	5.8
Liver	HUH1	6.6
Liver	HUH6	5.8
Liver	HUH7	5.9
Liver	JHH1	5.8
Liver	JHH2	6.5
Liver	JHH4	5.8
Liver	JHH5	6.4
Liver	JHH6	5.7
Liver	JHH7	5.9
Liver	LI7	5.7
Liver	PLCPRF5	5.9
Liver	SKHEP1	5.5
Liver	SNU182	5.6
Liver	SNU387	6
Liver	SNU398	6.1
Liver	SNU423	6
Liver	SNU449	5.9
Liver	SNU475	5.5
Liver	SNU761	6.5
Liver	SNU878	6.1
Liver	SNU886	6.2
Lung	A549	6.1
Lung	ABC1	5.9
Lung	BEN	6.1
Lung	CAL12T	6
Lung	CALU1	6.7
Lung	CALU3	5.8
Lung	CALU6	6.2
Lung	CHAGOK1	5.5
Lung	COLO668	6
Lung	COLO699	6.4
Lung	CORL105	6.3
Lung	CORL23	6.3
Lung	CORL24	5.6
Lung	CORL279	6.4
Lung	CORL311	6
Lung	CORL47	5.9
Lung	CORL51	5.7
Lung	CORL88	5.6
Lung	CORL95	5.9
Lung	CPCN	6.6
Lung	DMS114	5.8
Lung	DMS153	5.9
Lung	DMS273	6.2
Lung	DMS454	5.5
Lung	DMS53	5.8
Lung	DMS79	6
Lung	DV90	6
Lung	EBC1	6.2
Lung	EPLC272H	6.1
Lung	HARA	6.5
Lung	HCC1171	5.9
Lung	HCC1195	6.1
Lung	HCC15	6.3
Lung	HCC2279	6.5
Lung	HCC2935	5.8
Lung	HCC33	6.1
Lung	HCC366	5.6
Lung	HCC4006	6.1
Lung	HCC44	6.1
Lung	HCC78	6.1
Lung	HCC827	6.1
Lung	HCC95	5.8
Lung	HLC1	6.2
Lung	HLFA	5.9
Lung	HS229T	6.1
Lung	HS618T	6.1
Lung	IALM	5.6
Lung	KNS62	6
Lung	LC1F	5.6
Lung	LC1SQSF	5.7
Lung	LCLC103H	6.1
Lung	LCLC97TM1	5.8
Lung	LK2	6.3
Lung	LOUNH91	6.2
Lung	LU65	6.3
Lung	LU99	6
Lung	LUDLU1	5.9
Lung	LXF289	6.1
Lung	MORCPR	6
Lung	NCIH1048	5.9
Lung	NCIH1092	5.3
Lung	NCIH1105	5.6
Lung	NCIH1155	5.9
Lung	NCIH1184	5.8
Lung	NCIH1299	6.5
Lung	NCIH1339	6.3
Lung	NCIH1341	6.2
Lung	NCIH1355	5.6
Lung	NCIH1373	6.1
Lung	NCIH1385	6.4
Lung	NCIH1395	6.2
Lung	NCIH1435	6
Lung	NCIH1436	5.7
Lung	NCIH1437	6
Lung	NCIH146	5.8
Lung	NCIH1563	6
Lung	NCIH1568	5.8
Lung	NCIH1573	5.8
Lung	NCIH1581	5.8
Lung	NCIH1618	5.9
Lung	NCIH1623	6.1
Lung	NCIH1648	5.8
Lung	NCIH1650	5.5
Lung	NCIH1651	5.6
Lung	NCIH1666	5.9
Lung	NCIH1693	5.6
Lung	NCIH1694	5.9
Lung	NCIH1703	5.8
Lung	NCIH1734	6
Lung	NCIH1755	6.2
Lung	NCIH1781	5.8
Lung	NCIH1792	6
Lung	NCIH1793	6.5
Lung	NCIH1836	6.8
Lung	NCIH1838	5.9
Lung	NCIH1869	6.1
Lung	NCIH1876	5.6
Lung	NCIH1915	6.1
Lung	NCIH1930	6
Lung	NCIH1944	5.8
Lung	NCIH1963	5.9
Lung	NCIH196	5.7
Lung	NCIH1975	6.5
Lung	NCIH2009	6.2
Lung	NCIH2023	6.4
Lung	NCIH2029	5.9
Lung	NCIH2030	5.7
Lung	NCIH2066	6.1
Lung	NCIH2081	5.6
Lung	NCIH2085	6
Lung	NCIH2087	6.3
Lung	NCIH209	6
Lung	NCIH2106	6.5
Lung	NCIH2110	5.7
Lung	NCIH211	5.9
Lung	NCIH2122	6.3
Lung	NCIH2126	6
Lung	NCIH2141	6
Lung	NCIH2170	6.1
Lung	NCIH2171	6.6
Lung	NCIH2172	5.7
Lung	NCIH2196	6.1
Lung	NCIH2227	5.9
Lung	NCIH2228	6.2
Lung	NCIH226	6.1
Lung	NCIH2286	6.1
Lung	NCIH2291	6.4
Lung	NCIH2342	5.9
Lung	NCIH2347	6.1
Lung	NCIH23	7.2
Lung	NCIH2405	5.5
Lung	NCIH2444	6.1
Lung	NCIH292	6
Lung	NCIH322	5.9
Lung	NCIH3255	5.7
Lung	NCIH358	5.7
Lung	NCIH441	5.7
Lung	NCIH446	6.4
Lung	NCIH460	6.2
Lung	NCIH510	6.1
Lung	NCIH520	6.6
Lung	NCIH522	6
Lung	NCIH524	6.1
Lung	NCIH526	6
Lung	NCIH596	5.8
Lung	NCIH647	5.6
Lung	NCIH650	5.9
Lung	NCIH661	5.7
Lung	NCIH69	5.9
Lung	NCIH727	6
Lung	NCIH810	6.3
Lung	NCIH82	5.7
Lung	NCIH838	5.7
Lung	NCIH841	5.7
Lung	NCIH854	7.4
Lung	NCIH889	6.3
Lung	PC14	6
Lung	RERFLCAD1	5.9
Lung	RERFLCAD2	5.7
Lung	RERFLCAI	5.9
Lung	RERFLCKJ	6
Lung	RERFLCMS	6.3
Lung	RERFLCSQ1	5.6
Lung	SBC5	5.7
Lung	SCLC21H	5.7
Lung	SHP77	6.3
Lung	SKLU1	6.4
Lung	SKMES1	5.9
Lung	SQ1	6
Lung	SW1271	6.3
Lung	SW1573	5.9
Lung	SW900	6.2
Lung	VMRCLCD	6
Lung	VMRCLCP	5.8
Oesophagus	COLO680N	5.9
Oesophagus	ECGI10	6.3
Oesophagus	KYSE140	6.2
Oesophagus	KYSE150	6.6
Oesophagus	KYSE180	6.4
Oesophagus	KYSE270	5.7
Oesophagus	KYSE30	6.4
Oesophagus	KYSE410	5.8
Oesophagus	KYSE450	6.8
Oesophagus	KYSE510	6.2
Oesophagus	KYSE520	5.9
Oesophagus	KYSE70	6.3
Oesophagus	OE19	6.1
Oesophagus	OE33	5.9
Oesophagus	TE10	5.7
Oesophagus	TE11	5.8
Oesophagus	TE14	5.9
Oesophagus	TE15	5.6
Oesophagus	TE1	5.8
Oesophagus	TE4	6
Oesophagus	TE5	5.8
Oesophagus	TE6	6
Oesophagus	TE8	6.1
Oesophagus	TE9	6
Oesophagus	TT	5.9
Ovary	59M	5.9
Ovary	A2780	5.8
Ovary	CAOV3	5.8
Ovary	CAOV4	5.7
Ovary	COLO704	6.1
Ovary	COV318	6
Ovary	COV362	5.4
Ovary	COV434	5.8
Ovary	COV504	5.6
Ovary	COV644	5.7
Ovary	EFO21	5.8
Ovary	EFO27	6
Ovary	ES2	6.2
Ovary	FUOV1	5.7
Ovary	HEYA8	6.1
Ovary	HS571T	6
Ovary	IGROV1	6.1
Ovary	JHOC5	6.2
Ovary	JHOM1	5.9
Ovary	JHOM2B	6.2
Ovary	JHOS2	5.7
Ovary	JHOS4	5.6
Ovary	KURAMOCHI	5.3
Ovary	MCAS	6.3
Ovary	NIHOVCAR3	5.6
Ovary	OAW28	5.6
Ovary	OAW42	6.1
Ovary	OC314	6.1
Ovary	OC316	6.1
Ovary	ONCODG1	5.8
Ovary	OV56	6.1
Ovary	OV7	6.1
Ovary	OV90	6.1
Ovary	OVCAR4	5.7
Ovary	OVCAR8	5.6
Ovary	OVISE	6
Ovary	OVK18	6.3
Ovary	OVKATE	5.8
Ovary	OVMANA	5.9
Ovary	OVSAHO	5.8
Ovary	OVTOKO	6.1
Ovary	RMGI	6.4
Ovary	RMUGS	6.1
Ovary	SKOV3	5.9
Ovary	SNU119	5.8
Ovary	SNU840	5.8
Ovary	SNU8	5.8
Ovary	TOV112D	6.2
Ovary	TOV21G	5.8
Ovary	TYKNU	6.2
Pancreas	ASPC1	6.5
Pancreas	BXPC3	6
Pancreas	CAPAN1	6.1
Pancreas	CAPAN2	5.8
Pancreas	CFPAC1	5.7
Pancreas	DANG	5.8
Pancreas	HPAC	5.8
Pancreas	HPAFII	6.6
Pancreas	HS766T	5.9
Pancreas	HUPT3	6.4
Pancreas	HUPT4	6.1
Pancreas	KCIMOH1	6
Pancreas	KLM1	6.1
Pancreas	KP2	5.8
Pancreas	KP3	5.6
Pancreas	KP4	6
Pancreas	L33	6
Pancreas	MIAPACA2	6.7
Pancreas	PANC0203	6.2
Pancreas	PANC0213	6.1
Pancreas	PANC0327	5.9
Pancreas	PANC0403	5.9
Pancreas	PANC0504	5.7
Pancreas	PANC0813	6.2
Pancreas	PANC1005	6.2
Pancreas	PANC1	5.4
Pancreas	PATU8902	5.8
Pancreas	PATU8988S	5.9
Pancreas	PATU8988T	6
Pancreas	PK1	6.3
Pancreas	PK45H	5.9
Pancreas	PK59	6.3
Pancreas	PL45	5.9
Pancreas	PSN1	6.2
Pancreas	QGP1	6.3
Pancreas	SNU213	6.1
Pancreas	SNU324	6.4
Pancreas	SNU410	6.5
Pancreas	SU8686	5.6
Pancreas	SUIT2	5.8
Pancreas	SW1990	6.2
Pancreas	T3M4	6.2
Pancreas	TCCPAN2	6.4
Pancreas	YAPC	5.6
Pleura	ACCMESO1	6.1
Pleura	DM3	6.3
Pleura	ISTMES1	6.1
Pleura	ISTMES2	6.1
Pleura	JL1	6.3
Pleura	MPP89	6.1
Pleura	MSTO211H	6.1
Pleura	NCIH2052	5.9
Pleura	NCIH2452	6.2
Pleura	NCIH28	6.3
Prostate	22RV1	6.2
Prostate	DU145	6
Prostate	LNCAPCLONEFGC	5.9
Prostate	MDAPCA2B	6.3
Prostate	NCIH660	6
Prostate	PC3	5.8
Prostate	VCAP	5.6
Salivary gland	A253	5.8
Salivary gland	YD15	6.1
Skin	A101D	6.5
Skin	A2058	6.5
Skin	A375	6.3
Skin	C32	5.7
Skin	CHL1	6.2
Skin	CJM	6
Skin	COLO679	5.8
Skin	COLO741	6.1
Skin	COLO783	5.8
Skin	COLO792	5.9
Skin	COLO800	5.7
Skin	COLO818	5.8
Skin	COLO829	6.3
Skin	COLO849	6.4
Skin	G361	5.9
Skin	GRM	6.2
Skin	HMCB	6
Skin	HS294T	6.2
Skin	HS600T	6
Skin	HS688AT	6.2
Skin	HS695T	5.8
Skin	HS839T	6.2
Skin	HS852T	6.1
Skin	HS895T	5.8
Skin	HS934T	5.9
Skin	HS936T	5.8
Skin	HS939T	5.8
Skin	HS940T	5.9
Skin	HS944T	6.4
Skin	HT144	6.2
Skin	IGR1	5.9
Skin	IGR37	6.5
Skin	IGR39	6.6
Skin	IPC298	6.4
Skin	K029AX	6.1
Skin	LOXIMVI	6.2
Skin	MALME3M	5.8
Skin	MDAMB435S	6.6
Skin	MELHO	5.9
Skin	MELJUSO	6.1
Skin	MEWO	6.1
Skin	RPMI7951	6.1
Skin	RVH421	6
Skin	SH4	5.9
Skin	SKMEL1	5.8
Skin	SKMEL24	5.7
Skin	SKMEL28	6.1
Skin	SKMEL2	6.2
Skin	SKMEL30	6.1
Skin	SKMEL31	5.8
Skin	SKMEL3	5.8
Skin	SKMEL5	6
Skin	UACC257	6.2
Skin	UACC62	6.1
Skin	WM115	5.9
Skin	WM1799	5.8
Skin	WM2664	6.1
Skin	WM793	5.9
Skin	WM88	5.9
Skin	WM983B	5.7
Small intestine	HUTU80	6.2
Soft tissue	A204	5.7
Soft tissue	G401	5.9
Soft tissue	G402	6.2
Soft tissue	GCT	6.3
Soft tissue	HS729	6.2
Soft tissue	HT1080	6.4
Soft tissue	KYM1	5.9
Soft tissue	MESSA	6.5
Soft tissue	RD	6.1
Soft tissue	RH30	6.3
Soft tissue	RH41	5.7
Soft tissue	RKN	6.2
Soft tissue	S117	6.2
Soft tissue	SJRH30	5.9
Soft tissue	SKLMS1	6.4
Soft tissue	SKUT1	6.6
Soft tissue	TE125T	6.2
Soft tissue	TE159T	5.8
Soft tissue	TE441T	5.9
Soft tissue	TE617T	6.1
Stomach	2313287	6.1
Stomach	AGS	6
Stomach	AZ521	6.3
Stomach	ECC10	5.4
Stomach	ECC12	5.9
Stomach	FU97	6
Stomach	GCIY	5.7
Stomach	GSS	5.8
Stomach	GSU	6.3
Stomach	HGC27	6.3
Stomach	HS746T	6.3
Stomach	HUG1N	6.2
Stomach	IM95	6.6
Stomach	KATOIII	6.1
Stomach	KE39	5.7
Stomach	LMSU	6.6
Stomach	MKN1	5.7
Stomach	MKN45	6.2
Stomach	MKN74	5.7
Stomach	MKN7	5.9
Stomach	NCCSTCK140	5.8
Stomach	NCIN87	5.7
Stomach	NUGC2	6.5
Stomach	NUGC3	6.7
Stomach	NUGC4	5.9
Stomach	OCUM1	6.6
Stomach	RERFGC1B	5.9
Stomach	SH10TC	5.8
Stomach	SNU16	6.2
Stomach	SNU1	6.1
Stomach	SNU216	6.5
Stomach	SNU520	6.5
Stomach	SNU5	6.4
Stomach	SNU601	5.9
Stomach	SNU620	6.3
Stomach	SNU668	5.6
Stomach	SNU719	7.2
Stomach	TGBC11TKB	6.3
Thyroid	8305C	6.1
Thyroid	8505C	6.2
Thyroid	BCPAP	6.4
Thyroid	BHT101	6
Thyroid	CAL62	6
Thyroid	CGTHW1	6
Thyroid	FTC133	6.3
Thyroid	FTC238	5.9
Thyroid	ML1	5.5
Thyroid	SW579	6.3
Thyroid	TT2609C02	6.1
Thyroid	TT	5.9
Upper aerodigestive tract	BHY	5.8
Upper aerodigestive tract	BICR16	6.5
Upper aerodigestive tract	BICR18	6
Upper aerodigestive tract	BICR22	6.3
Upper aerodigestive tract	BICR31	5.7
Upper aerodigestive tract	BICR56	6
Upper aerodigestive tract	BICR6	6.1
Upper aerodigestive tract	CAL27	6.3
Upper aerodigestive tract	CAL33	5.8
Upper aerodigestive tract	DETROIT562	5.4
Upper aerodigestive tract	FADU	6
Upper aerodigestive tract	HS840T	6.2
Upper aerodigestive tract	HSC2	5.9
Upper aerodigestive tract	HSC3	6
Upper aerodigestive tract	HSC4	5.8
Upper aerodigestive tract	PECAPJ15	5.7
Upper aerodigestive tract	PECAPJ34CLONEC12	6
Upper aerodigestive tract	PECAPJ41CLONED2	5.8
Upper aerodigestive tract	PECAPJ49	5.7
Upper aerodigestive tract	SCC15	6.2
Upper aerodigestive tract	SCC25	5.8
Upper aerodigestive tract	SCC4	6
Upper aerodigestive tract	SCC9	5.8
Upper aerodigestive tract	SNU1076	6
Upper aerodigestive tract	SNU1214	5.8
Upper aerodigestive tract	SNU46	6.8
Upper aerodigestive tract	SNU899	5.8
Upper aerodigestive tract	YD10B	5.8
Upper aerodigestive tract	YD38	6.1
Upper aerodigestive tract	YD8	6.1
Urinary tract	5637	6.7
Urinary tract	639V	6.1
Urinary tract	647V	6
Urinary tract	BC3C	6.2
Urinary tract	BFTC905	6
Urinary tract	CAL29	5.7
Urinary tract	HS172T	5.8
Urinary tract	HT1197	6
Urinary tract	HT1376	6
Urinary tract	J82	6
Urinary tract	JMSU1	6.6
Urinary tract	KMBC2	5.8
Urinary tract	KU1919	5.8
Urinary tract	RT11284	5.8
Urinary tract	RT112	6.2
Urinary tract	RT4	6
Urinary tract	SCABER	6
Urinary tract	SW1710	6.2
Urinary tract	SW780	5.6
Urinary tract	T24	5.8
Urinary tract	TCCSUP	6.2
Urinary tract	UMUC1	6.5
Urinary tract	UMUC3	5.7
Urinary tract	VMCUB1	6.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	5.2
Adrenal gland	7
Appendix	10.5
Bone marrow	6.4
Breast	2.6
Cerebral cortex	8.1
Cervix, uterine	4.5
Colon	13.5
Duodenum	10
Endometrium	5.9
Epididymis	2.9
Esophagus	3.1
Fallopian tube	5.4
Gallbladder	5.2
Heart muscle	2.6
Kidney	3.4
Liver	1.3
Lung	6.1
Lymph node	7.9
Ovary	3.7
Pancreas	1.8
Parathyroid gland	6.6
Placenta	6
Prostate	6
Rectum	8.1
Salivary gland	2.6
Seminal vesicle	7
Skeletal muscle	1.8
Skin	7.6
Small intestine	10.5
Smooth muscle	3.6
Spleen	10.3
Stomach	7.2
Testis	5.1
Thyroid gland	3.7
Tonsil	3.6
Urinary bladder	4.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26648570	Overexpression	Glioma	Immunoblotting and immunofluorescent staining demonstrated that SIRT6 overexpression promoted the mitochondrial-tonuclear translocation of apoptosisinducing factor (AIF), a potent apoptosis inducer.
26180037	Aberrant Expression	Non-Small Cell Lung Cancer	Patients with high cytoplasmic expression and low nuclear expression of SIRT6 (n = 33) had more aggressive cancer, shorter overall survival, and shorter recurrence-free survival than did patients with different SIRT6 expression profiles (P < 0.05).
25807436	Underexpression	Ovarian Carcinoma	We found that the SIRT6 expression was significantly reduced in human ovarian cancer tissues compared to the normal tissues.
25713071	Underexpression	Lung Carcinoma	Activation of cAMP signaling reduced SIRT6 protein expression in lung cancer cells.
25503141	Overexpression	Head and Neck Squamous Cell Carcinoma	In the cancer group, the expression level of SIRT1 was down-regulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001).
25400728	Underexpression	Urothelial Carcinoma	Immunohistochemistry studies of SIRT6 on radical cystectomy samples showed a dramatic decline of SIRT6 expression when bladder cancer progressed from T2 to T4.
25320180	Overexpression	Human Skin Squamous Cell Carcinoma	Clinically, we found that SIRT6 was upregulated in human skin squamous cell carcinoma.
25197348	Underexpression	Non-Small Cell Lung Cancer	The present study showed that the mRNA and protein levels of SIRT6 were decreased in human non-small cell lung cancer (NSCLC) tissues and cell lines.
24607900	Underexpression	Glioma	We find that SIRT6, one of the NAD(+)-dependent class III deacetylase SIRTUINs, is down-regulated in human glioma tissues and that the level of SIRT6 is negatively correlated with PCBP2 level while H3K9ac enrichment on the promoter of PCBP2 is positively correlated with PCBP2 expression.
23982738	Overexpression	Prostate Carcinoma	From deposited gene profiling studies we found that SIRT6 was overexpressed in prostate tumors, compared with normal or paratumor prostate tissues.
23514751	Overexpression	Breast Carcinoma	Consistently, immunohistochemical analysis of 118 breast cancer patient samples revealed that high SIRT6 nuclear staining is significantly associated with poorer overall survival (P = 0.018; Kaplan-Meier analysis).
21207424	Aberrant Expression	Endometrial Carcinoma	We identified ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, SOCS2 and DCN as differentially expressed in ECs.
23475622	Underexpression	Head and Neck Squamous Cell Carcinoma	Our results demonstrated that the expression levels of SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, and SIRT7 were significantly downregulated in cancerous tissues compared with noncancerous tissues (all p<0.01).
27746184	Aberrant Expression	Breast Carcinoma	Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis.
28656307	Underexpression	Gastric Carcinoma	In this study, we found that SIRT6 expression level was decreased in gastric cancer tissues and cell lines. Decreased SIRT6 expression was associated with unfavorable clinical parameters including tumor differentiation, tumor size and TNM stage.
28653878	Overexpression	Oesophagal Squamous Cell Carcinoma	In the study, data from quantitative reverse transcriptase polymerase chain reaction-based assays and immunohistochemical assays revealed that sirtuin 6 was remarkably overexpressed in esophageal squamous tumor tissues.
28393212	Overexpression	Thyroid Carcinoma	SIRT6 mRNA and protein levels were upregulated in PTC tumor tissues and its overexpression was an independent biomarker for nodal metastasis (odds ratio=1.794, 95% confidence interval: 1.2561.920, p=0.012). SIRT6 expression was related to poor recurrencefree survival, however, not significantly.
27824900	Overexpression	Hepatocellular Carcinoma	SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients than in an immortalized hepatocyte cell line, THLE-2 and non-tumor tissues, respectively.

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.471	1.19e-23	35.1	50.5	14.4	Loss
BRCA	Breast invasive carcinoma	1075	0.343	5.38e-31	28.2	57.5	14.3	Neutral
CESC	Cervical and endocervical cancers	292	0.499	8.81e-20	34.2	54.8	11	Loss
COAD	Colon adenocarcinoma	449	0.28	1.59e-09	13.1	71.9	14.9	Neutral
ESCA	Esophageal carcinoma	183	0.551	6.83e-16	47.5	39.3	13.1	Loss
GBM	Glioblastoma multiforme	147	0.608	3.15e-16	8.8	55.8	35.4	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.455	1.43e-27	29	61.5	9.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.105	0.0163	3.2	88	8.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.22	0.000167	7.6	91	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.132	0.0911	2.4	94.6	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.294	1.17e-11	4.5	73.1	22.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.38	5.52e-14	22.8	63.2	14	Neutral
LUAD	Lung adenocarcinoma	512	0.333	1.01e-14	53.9	42.4	3.7	Loss
LUSC	Lung squamous cell carcinoma	498	0.465	4.15e-28	43.4	39.8	16.9	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.69	1.07e-43	85.7	10	4.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.278	0.000181	18.6	75.1	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.118	0.136	0.6	84.6	14.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.218	1.1e-06	7.5	91	1.4	Neutral
READ	Rectum adenocarcinoma	164	0.352	3.78e-06	22	60.4	17.7	Neutral
SARC	Sarcoma	255	0.333	5.22e-08	13.7	48.6	37.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.428	8.26e-18	25.9	57.8	16.3	Neutral
STAD	Stomach adenocarcinoma	413	0.331	4.89e-12	37.3	56.2	6.5	Loss
TGCT	Testicular Germ Cell Tumors	150	0.363	4.88e-06	31.3	44.7	24	Neutral
THCA	Thyroid carcinoma	497	0.24	6.42e-08	1.6	97	1.4	Neutral
THYM	Thymoma	119	-0.107	0.247	2.5	94.1	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.525	2.15e-39	28.7	68.9	2.4	Neutral

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR [ TOP ]
There is no record.

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0188	Significant	24476821
BRCA	Breast invasive carcinoma	521	0.28	NS	23000897
COAD	Colon adenocarcinoma	149	0.0991	NS	22810696
GBM	Glioblastoma multiforme	157	0.00027	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.001	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.6	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.000139	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.08	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.12	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00696	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00512	Significant	26544944
READ	Rectum adenocarcinoma	67	0.946	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.943	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0124	Significant	25079317
THCA	Thyroid carcinoma	391	0.000405	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	5.49e-08	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.536	0.0051	Longer
BRCA	Breast invasive carcinoma	1079	1.075	0.759	NS
CESC	Cervical and endocervical cancers	291	0.62	0.153	NS
COAD	Colon adenocarcinoma	439	0.912	0.749	NS
ESCA	Esophageal carcinoma	184	0.98	0.952	NS
GBM	Glioblastoma multiforme	158	1.015	0.958	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.78	0.201	NS
KIRC	Kidney renal clear cell carcinoma	531	1.954	0.00266	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.865	0.731	NS
LAML	Acute Myeloid Leukemia	149	1.892	0.0301	Shorter
LGG	Brain Lower Grade Glioma	511	0.805	0.419	NS
LIHC	Liver hepatocellular carcinoma	365	1.265	0.326	NS
LUAD	Lung adenocarcinoma	502	1.086	0.681	NS
LUSC	Lung squamous cell carcinoma	494	0.759	0.163	NS
OV	Ovarian serous cystadenocarcinoma	303	0.871	0.513	NS
PAAD	Pancreatic adenocarcinoma	177	0.675	0.156	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.034	0.981	NS
PRAD	Prostate adenocarcinoma	497	606448954.522	0.0434	Shorter
READ	Rectum adenocarcinoma	159	1.596	0.465	NS
SARC	Sarcoma	259	0.66	0.147	NS
SKCM	Skin Cutaneous Melanoma	459	1.121	0.571	NS
STAD	Stomach adenocarcinoma	388	0.56	0.0127	Longer
TGCT	Testicular Germ Cell Tumors	134	0.273	0.235	NS
THCA	Thyroid carcinoma	500	0.562	0.424	NS
THYM	Thymoma	119	0.775	0.756	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.373	0.00192	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.17	0.000561	Lower
BRCA	Breast invasive carcinoma	1071	0.042	0.169	NS
CESC	Cervical and endocervical cancers	167	0.022	0.781	NS
COAD	Colon adenocarcinoma	445	0.01	0.834	NS
ESCA	Esophageal carcinoma	162	-0.119	0.133	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.005	0.92	NS
KIRC	Kidney renal clear cell carcinoma	531	0.172	6.92e-05	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.057	0.36	NS
LIHC	Liver hepatocellular carcinoma	347	0.013	0.808	NS
LUAD	Lung adenocarcinoma	507	0.033	0.462	NS
LUSC	Lung squamous cell carcinoma	497	0.089	0.0472	Higher
OV	Ovarian serous cystadenocarcinoma	302	0.058	0.314	NS
PAAD	Pancreatic adenocarcinoma	176	-0.157	0.0381	Lower
READ	Rectum adenocarcinoma	156	0.069	0.39	NS
SKCM	Skin Cutaneous Melanoma	410	-0.064	0.197	NS
STAD	Stomach adenocarcinoma	392	-0.071	0.163	NS
TGCT	Testicular Germ Cell Tumors	81	-0.005	0.961	NS
THCA	Thyroid carcinoma	499	0.075	0.0951	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.116	0.00956	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.054	0.377	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.036	0.427	NS
KIRC	Kidney renal clear cell carcinoma	525	0.156	0.000322	Higher
LGG	Brain Lower Grade Glioma	514	0.038	0.388	NS
LIHC	Liver hepatocellular carcinoma	366	0.09	0.0839	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.061	0.299	NS
PAAD	Pancreatic adenocarcinoma	176	-0.067	0.38	NS
STAD	Stomach adenocarcinoma	406	-0.061	0.217	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.239	2.19e-08	Lower

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SIRT6.

Summary
Symbol	SIRT6
Name	sirtuin 6
Aliases	sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; sirtuin (silent mating type ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for SIRT6.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25713071	Lung Carcinoma	upstream	cAMP	negative regulation	Activation of cAMP signaling reduced SIRT6 protein expression in lung cancer cells.
25197348	Non-Small Cell Lung Cancer	downstream	Twist1	Negative regulation	On the molecular level, we found that SIRT6 inhibited the expression of Twist1 both at the mRNA and protein levels in NSCLC cells.
27746184	Breast Carcinoma	upstream	CSNK2A1	regulation	In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an invitro kinase assay, and transfection of mutant CSNK2A1.
27746184	Breast Carcinoma	partner	β-catenin	Association	Especially, SIRT6 expression was associated with the nuclear localization of β-catenin
28653878	Oesophagal Squamous Cell Carcinoma	partner	ULK1	Interaction	In addition, results from western blotting assays and immunoprecipitation assays displayed that sirtuin 6 specifically interacted with ULK1 and positively regulated its activity by inhibiting its upstream factor mammalian target of rapamycin activity.