CR2Cancer

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF07533 BRK domain
PF00439 Bromodomain
PF00271 Helicase conserved C-terminal domain
PF07529 HSA
PF08880 QLQ
PF14619 Snf2-ATP coupling
PF00176 SNF2 family N-terminal domain

Function

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3, DNA motif	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0006338 chromatin remodeling GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0016049 cell growth GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030308 negative regulation of cell growth GO:0045926 negative regulation of growth GO:0048232 male gamete generation GO:0048515 spermatid differentiation
Molecular Function	GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004386 helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0042393 histone binding GO:0042623 ATPase activity, coupled GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016514 SWI/SNF complex GO:0044454 nuclear chromosome part GO:0045111 intermediate filament cytoskeleton GO:0070603 SWI/SNF superfamily-type complex GO:0071564 npBAF complex GO:0071565 nBAF complex GO:0090544 BAF-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214858: RMTs methylate histone arginines

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1107898	c.4760C>T	p.T1587M	Substitution - Missense	Endometrium
COSM4163690	c.707A>C	p.Q236P	Substitution - Missense	Thyroid
COSM5723957	c.1898C>T	p.S633F	Substitution - Missense	Skin
COSM285194	c.232G>A	p.D78N	Substitution - Missense	Large_intestine
COSM1461712	c.1424A>C	p.K475T	Substitution - Missense	Large_intestine
COSM3656604	c.4108C>T	p.R1370C	Substitution - Missense	Large_intestine
COSM6013356	c.2322C>G	p.G774G	Substitution - coding silent	Skin
COSM1461696	c.1017C>T	p.P339P	Substitution - coding silent	Large_intestine
COSM5711272	c.399C>G	p.H133Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3091823	c.3078G>A	p.E1026E	Substitution - coding silent	Large_intestine
COSM5799033	c.1397A>T	p.H466L	Substitution - Missense	Breast
COSM5998224	c.1046+6G>A	p.?	Unknown	Prostate
COSM3906627	c.4539G>T	p.E1513D	Substitution - Missense	Stomach
COSM3686394	c.717_719delGCA	p.Q242delQ	Deletion - In frame	Large_intestine
COSM1461693	c.711G>A	p.Q237Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Large_intestine
COSM5496173	c.651A>G	p.Q217Q	Substitution - coding silent	Biliary_tract
COSM1169164	c.1250G>A	p.R417Q	Substitution - Missense	Pancreas
COSM4728277	c.2516T>G	p.I839S	Substitution - Missense	Large_intestine
COSM247462	c.3410C>T	p.A1137V	Substitution - Missense	Prostate
COSM1179000	c.3558G>A	p.A1186A	Substitution - coding silent	Prostate
COSM1107677	c.79C>A	p.L27I	Substitution - Missense	Endometrium
COSM1624841	c.1023A>T	p.E341D	Substitution - Missense	Liver
COSM3906563	c.3314G>A	p.R1105H	Substitution - Missense	Stomach
COSM374911	c.2258T>G	p.L753R	Substitution - Missense	Lung
COSM1700786	c.1952C>T	p.S651F	Substitution - Missense	Skin
COSM3656571	c.3852C>T	p.I1284I	Substitution - coding silent	Skin
COSM5063852	c.3352C>A	p.Q1118K	Substitution - Missense	Stomach
COSM1107885	c.4431C>T	p.N1477N	Substitution - coding silent	Endometrium
COSM364119	c.4025G>T	p.R1342L	Substitution - Missense	Lung
COSM1107817	c.3925C>T	p.R1309C	Substitution - Missense	Endometrium
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Cervix
COSM1461706	c.1280G>A	p.R427H	Substitution - Missense	Large_intestine
COSM1700788	c.3386G>T	p.G1129V	Substitution - Missense	Skin
COSM3656494	c.1407G>T	p.V469V	Substitution - coding silent	Skin
COSM4548013	c.4370G>A	p.R1457H	Substitution - Missense	Skin
COSM1266208	c.664_666delCAA	p.Q238delQ	Deletion - In frame	Oesophagus
COSM5036668	c.1329A>C	p.K443N	Substitution - Missense	Oesophagus
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Biliary_tract
COSM3788236	c.334C>T	p.P112S	Substitution - Missense	Pancreas
COSM218987	c.2759C>T	p.T920I	Substitution - Missense	Pancreas
COSM3906586	c.3797G>A	p.R1266Q	Substitution - Missense	Stomach
COSM5738531	c.2456G>A	p.R819Q	Substitution - Missense	Small_intestine
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Large_intestine
COSM5697345	c.876C>T	p.P292P	Substitution - coding silent	Soft_tissue
COSM5711281	c.3918G>C	p.R1306S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3413553	c.210G>C	p.M70I	Substitution - Missense	Central_nervous_system
COSM5711279	c.3220C>A	p.Q1074K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1314715	c.2812C>A	p.L938I	Substitution - Missense	Urinary_tract
COSM4387382	c.3392T>C	p.L1131P	Substitution - Missense	Lung
COSM3848235	c.380C>T	p.P127L	Substitution - Missense	Breast
COSM5800832	c.1563G>C	p.K521N	Substitution - Missense	Breast
COSM4408969	c.4638C>G	p.D1546E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5977200	c.666_667insCAGCAGCAG	p.Q238_P239insQQQ	Insertion - In frame	Upper_aerodigestive_tract
COSM3656507	c.2691C>T	p.F897F	Substitution - coding silent	Skin
COSM1461743	c.3466G>A	p.A1156T	Substitution - Missense	Liver
COSM1266214	c.2394T>A	p.S798S	Substitution - coding silent	Oesophagus
COSM5700953	c.2096A>T	p.Q699L	Substitution - Missense	Soft_tissue
COSM753806	c.166C>T	p.P56S	Substitution - Missense	Lung
COSM4163695	c.1345C>A	p.Q449K	Substitution - Missense	Thyroid
COSM217448	c.545delT	p.R183fs*5	Deletion - Frameshift	Liver
COSM1674364	c.2423C>T	p.P808L	Substitution - Missense	Prostate
COSM5659318	c.4461+1G>T	p.?	Unknown	Soft_tissue
COSM4728283	c.4480G>A	p.V1494I	Substitution - Missense	Oesophagus
COSM1461724	c.2397G>A	p.V799V	Substitution - coding silent	Large_intestine
COSM5922767	c.3350C>T	p.S1117F	Substitution - Missense	Skin
COSM753794	c.2301G>A	p.M767I	Substitution - Missense	Lung
COSM3395736	c.2052C>T	p.D684D	Substitution - coding silent	Pancreas
COSM315433	c.3201C>A	p.H1067Q	Substitution - Missense	Soft_tissue
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Upper_aerodigestive_tract
COSM4588732	c.1884A>G	p.E628E	Substitution - coding silent	Bone
COSM4728283	c.4480G>A	p.V1494I	Substitution - Missense	Large_intestine
COSM233446	c.511C>T	p.P171S	Substitution - Missense	Skin
COSM5035330	c.2723C>T	p.T908I	Substitution - Missense	Oesophagus
COSM4791566	c.2123T>C	p.I708T	Substitution - Missense	Liver
COSM277378	c.4261C>T	p.R1421*	Substitution - Nonsense	Large_intestine
COSM3656608	c.4173C>T	p.I1391I	Substitution - coding silent	Skin
COSM5124942	c.1692+4C>T	p.?	Unknown	Large_intestine
COSM3906508	c.568A>G	p.K190E	Substitution - Missense	Stomach
COSM4633065	c.731C>A	p.P244Q	Substitution - Missense	Large_intestine
COSM1107714	c.1738G>A	p.D580N	Substitution - Missense	Endometrium
COSM4748644	c.4396G>A	p.D1466N	Substitution - Missense	Stomach
COSM5202462	c.1664_1666delAGA	p.K558delK	Deletion - In frame	Breast
COSM3656604	c.4108C>T	p.R1370C	Substitution - Missense	Skin
COSM5723957	c.1898C>T	p.S633F	Substitution - Missense	Skin
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Skin
COSM1107674	c.9G>A	p.T3T	Substitution - coding silent	Endometrium
COSM315431	c.3613G>T	p.D1205Y	Substitution - Missense	Lung
COSM1107711	c.1663_1664insAGA	p.K558_R559insK	Insertion - In frame	Endometrium
COSM1664267	c.395A>C	p.E132A	Substitution - Missense	Kidney
COSM3848239	c.705G>A	p.Q235Q	Substitution - coding silent	Stomach
COSM487313	c.3684+1G>A	p.?	Unknown	Kidney
COSM4964189	c.3313C>T	p.R1105C	Substitution - Missense	Liver
COSM3906522	c.1673A>G	p.K558R	Substitution - Missense	Stomach
COSM1107721	c.2337T>A	p.I779I	Substitution - coding silent	Endometrium
COSM487307	c.1289A>T	p.E430V	Substitution - Missense	Kidney
COSM217448	c.545delT	p.R183fs*5	Deletion - Frameshift	Liver
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Stomach
COSM1636136	c.3445A>G	p.N1149D	Substitution - Missense	Liver
COSM173127	c.2530C>T	p.R844W	Substitution - Missense	Large_intestine
COSM1645008	c.3377C>T	p.T1126I	Substitution - Missense	Salivary_gland
COSM78544	c.1070G>T	p.R357M	Substitution - Missense	Ovary
COSM5991853	c.225_225+2delGGT	p.?	Unknown	Prostate
COSM4728271	c.708A>G	p.Q236Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3906558	c.3139C>T	p.R1047W	Substitution - Missense	Stomach
COSM6013358	c.2348+3A>G	p.?	Unknown	Skin
COSM3656604	c.4108C>T	p.R1370C	Substitution - Missense	Large_intestine
COSM422396	c.3448C>T	p.P1150S	Substitution - Missense	Urinary_tract
COSM3656497	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM3763857	c.3672G>A	p.E1224E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5769692	c.1111G>T	p.D371Y	Substitution - Missense	Breast
COSM1658954	c.2564G>A	p.R855Q	Substitution - Missense	Large_intestine
COSM3848239	c.705G>A	p.Q235Q	Substitution - coding silent	Breast
COSM3906584	c.3763C>T	p.R1255W	Substitution - Missense	Large_intestine
COSM5716253	c.531C>T	p.V177V	Substitution - coding silent	Skin
COSM3906506	c.494G>A	p.S165N	Substitution - Missense	Stomach
COSM5815368	c.677A>T	p.Q226L	Substitution - Missense	Liver
COSM5041182	c.2561A>G	p.H854R	Substitution - Missense	Liver
COSM3656489	c.596C>T	p.P199L	Substitution - Missense	Skin
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Soft_tissue
COSM422399	c.2683C>G	p.L895V	Substitution - Missense	Urinary_tract
COSM285196	c.3863A>G	p.D1288G	Substitution - Missense	Large_intestine
COSM4958267	c.2336T>C	p.I779T	Substitution - Missense	Liver
COSM1624851	c.2983G>C	p.D995H	Substitution - Missense	Liver
COSM3656615	c.4506C>T	p.A1502A	Substitution - coding silent	Skin
COSM1461726	c.2459G>A	p.S820N	Substitution - Missense	Large_intestine
COSM5743319	c.1877G>A	p.G626D	Substitution - Missense	Small_intestine
COSM4163693	c.1344C>G	p.H448Q	Substitution - Missense	Thyroid
COSM4805192	c.3452A>G	p.H1151R	Substitution - Missense	Liver
COSM3848251	c.3382G>A	p.A1128T	Substitution - Missense	Breast
COSM3091901	c.3637C>T	p.R1213W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2149273	c.476G>A	p.G159D	Substitution - Missense	Central_nervous_system
COSM1107693	c.1059C>T	p.R353R	Substitution - coding silent	Endometrium
COSM1461717	c.2234G>A	p.G745E	Substitution - Missense	Large_intestine
COSM1226752	c.3962C>T	p.T1321M	Substitution - Missense	Large_intestine
COSM4789563	c.3464A>T	p.Q1155L	Substitution - Missense	Liver
COSM5418745	c.1626T>A	p.N542K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1107705	c.1399C>T	p.R467W	Substitution - Missense	Endometrium
COSM234108	c.2884-10T>G	p.?	Unknown	Skin
COSM4408969	c.4638C>G	p.D1546E	Substitution - Missense	Soft_tissue
COSM5410917	c.279C>T	p.S93S	Substitution - coding silent	Skin
COSM277378	c.4261C>T	p.R1421*	Substitution - Nonsense	Large_intestine
COSM4460792	c.117C>G	p.S39S	Substitution - coding silent	Skin
COSM1107882	c.4171A>G	p.I1391V	Substitution - Missense	Endometrium
COSM4152228	c.1783G>T	p.V595F	Substitution - Missense	Ovary
COSM3091815	c.2936G>A	p.R979H	Substitution - Missense	Large_intestine
COSM5831039	c.683_684insGCC	p.Q228_Q229insP	Insertion - In frame	Large_intestine
COSM3906590	c.3894A>G	p.E1298E	Substitution - coding silent	Stomach
COSM5610608	c.3005C>G	p.A1002G	Substitution - Missense	Skin
COSM3716168	c.1989T>G	p.D663E	Substitution - Missense	Upper_aerodigestive_tract
COSM1496999	c.356-2A>T	p.?	Unknown	Kidney
COSM3092203	c.4371T>C	p.R1457R	Substitution - coding silent	Large_intestine
COSM608519	c.1249C>T	p.R417W	Substitution - Missense	Large_intestine
COSM1624841	c.1023A>T	p.E341D	Substitution - Missense	Liver
COSM5788223	c.4768G>T	p.E1590*	Substitution - Nonsense	Breast
COSM3656487	c.501C>T	p.P167P	Substitution - coding silent	Skin
COSM1732544	c.2872C>T	p.L958F	Substitution - Missense	Soft_tissue
COSM3906631	c.4660G>T	p.G1554C	Substitution - Missense	Stomach
COSM3092225	c.4734A>G	p.E1578E	Substitution - coding silent	Large_intestine
COSM5569924	c.1223C>T	p.T408M	Substitution - Missense	Prostate
COSM1624846	c.2350A>G	p.T784A	Substitution - Missense	Liver
COSM4933600	c.209T>C	p.M70T	Substitution - Missense	Liver
COSM5673868	c.2184+1G>T	p.?	Unknown	Soft_tissue
COSM5455774	c.1470G>T	p.E490D	Substitution - Missense	Large_intestine
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Large_intestine
COSM3906588	c.3879G>T	p.R1293S	Substitution - Missense	Stomach
COSM3091651	c.1375G>T	p.A459S	Substitution - Missense	Large_intestine
COSM285194	c.232G>A	p.D78N	Substitution - Missense	Large_intestine
COSM4443616	c.1714G>T	p.G572C	Substitution - Missense	Large_intestine
COSM1266222	c.2570A>C	p.K857T	Substitution - Missense	Oesophagus
COSM3926630	c.4413C>T	p.V1471V	Substitution - coding silent	Skin
COSM1107727	c.2406T>G	p.I802M	Substitution - Missense	Endometrium
COSM4728269	c.421G>T	p.G141*	Substitution - Nonsense	Large_intestine
COSM3656481	c.143C>T	p.P48L	Substitution - Missense	Skin
COSM5998224	c.1046+6G>A	p.?	Unknown	Prostate
COSM753802	c.584G>T	p.G195V	Substitution - Missense	Lung
COSM252830	c.3484C>T	p.R1162C	Substitution - Missense	Ovary
COSM3092225	c.4734A>G	p.E1578E	Substitution - coding silent	Large_intestine
COSM1700790	c.3449C>T	p.P1150L	Substitution - Missense	Skin
COSM5979658	c.4147C>A	p.L1383M	Substitution - Missense	Upper_aerodigestive_tract
COSM217448	c.545delT	p.R183fs*5	Deletion - Frameshift	Liver
COSM1107876	c.4118C>G	p.A1373G	Substitution - Missense	Endometrium
COSM3906616	c.4022T>C	p.V1341A	Substitution - Missense	Stomach
COSM5492478	c.884C>T	p.A295V	Substitution - Missense	Biliary_tract
COSM3788236	c.334C>T	p.P112S	Substitution - Missense	Pancreas
COSM1624857	c.3559G>C	p.A1187P	Substitution - Missense	Liver
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Large_intestine
COSM4588734	c.1924T>C	p.Y642H	Substitution - Missense	Bone
COSM5515285	c.3173T>G	p.I1058S	Substitution - Missense	Biliary_tract
COSM5359332	c.350G>A	p.S117N	Substitution - Missense	Large_intestine
COSM4728271	c.708A>G	p.Q236Q	Substitution - coding silent	Soft_tissue
COSM4556314	c.687G>A	p.Q229Q	Substitution - coding silent	Skin
COSM5711276	c.1607A>G	p.Y536C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Skin
COSM1266224	c.1131C>T	p.T377T	Substitution - coding silent	Stomach
COSM5359403	c.136C>T	p.P46S	Substitution - Missense	Large_intestine
COSM3091589	c.243T>C	p.H81H	Substitution - coding silent	Large_intestine
COSM4728273	c.744_745insA	p.Q249fs*10	Insertion - Frameshift	Large_intestine
COSM3091857	c.3141G>A	p.R1047R	Substitution - coding silent	Central_nervous_system
COSM1226746	c.1302G>T	p.K434N	Substitution - Missense	Large_intestine
COSM3765444	c.2432G>A	p.R811H	Substitution - Missense	Central_nervous_system
COSM3656499	c.1969G>A	p.E657K	Substitution - Missense	Skin
COSM3091823	c.3078G>A	p.E1026E	Substitution - coding silent	Large_intestine
COSM753804	c.279C>A	p.S93S	Substitution - coding silent	Lung
COSM5711274	c.666_667insCAG	p.Q238_P239insQ	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1624855	c.3502G>A	p.E1168K	Substitution - Missense	Pancreas
COSM1226750	c.4045C>T	p.R1349*	Substitution - Nonsense	Biliary_tract
COSM1314719	c.3366C>G	p.F1122L	Substitution - Missense	Urinary_tract
COSM1137984	c.414G>A	p.M138I	Substitution - Missense	Kidney
COSM2149273	c.476G>A	p.G159D	Substitution - Missense	Central_nervous_system
COSM1674366	c.4733A>G	p.E1578G	Substitution - Missense	Large_intestine
COSM364821	c.3779G>T	p.R1260L	Substitution - Missense	Lung
COSM1461691	c.683A>C	p.Q228P	Substitution - Missense	Upper_aerodigestive_tract
COSM4588736	c.2929C>T	p.L977L	Substitution - coding silent	Bone
COSM1266210	c.306T>C	p.P102P	Substitution - coding silent	Stomach
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Prostate
COSM3926602	c.3360C>T	p.F1120F	Substitution - coding silent	Skin
COSM3952618	c.3666G>A	p.E1222E	Substitution - coding silent	Lung
COSM1624853	c.3485G>T	p.R1162L	Substitution - Missense	Liver
COSM2151451	c.3292G>A	p.G1098S	Substitution - Missense	Central_nervous_system
COSM1107814	c.3911T>C	p.F1304S	Substitution - Missense	Endometrium
COSM3367671	c.2191G>T	p.G731C	Substitution - Missense	Kidney
COSM4187479	c.3983C>T	p.A1328V	Substitution - Missense	Kidney
COSM4609450	c.2887G>T	p.E963*	Substitution - Nonsense	Adrenal_gland
COSM5835715	c.2526+1_2526+2insACA	p.?	Unknown	Breast
COSM1107696	c.1132G>T	p.V378L	Substitution - Missense	Endometrium
COSM78543	c.404C>A	p.S135Y	Substitution - Missense	Ovary
COSM3703531	c.4611G>A	p.V1537V	Substitution - coding silent	Liver
COSM3656504	c.2445C>T	p.V815V	Substitution - coding silent	Skin
COSM1107895	c.4500G>A	p.K1500K	Substitution - coding silent	Endometrium
COSM3906510	c.576G>A	p.L192L	Substitution - coding silent	Stomach
COSM1107898	c.4760C>T	p.T1587M	Substitution - Missense	Endometrium
COSM5784226	c.1178G>C	p.R393T	Substitution - Missense	Breast
COSM3656608	c.4173C>T	p.I1391I	Substitution - coding silent	Stomach
COSM3848239	c.705G>A	p.Q235Q	Substitution - coding silent	Large_intestine
COSM1107708	c.1403C>T	p.S468F	Substitution - Missense	Endometrium
COSM4170023	c.2490T>A	p.Y830*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM753796	c.2251A>G	p.M751V	Substitution - Missense	Lung
COSM1461793	c.4112C>A	p.P1371H	Substitution - Missense	Large_intestine
COSM5771336	c.3796C>G	p.R1266G	Substitution - Missense	Breast
COSM5487276	c.3810G>A	p.R1270R	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3906504	c.392C>A	p.P131Q	Substitution - Missense	Stomach
COSM1107879	c.4165G>A	p.A1389T	Substitution - Missense	Endometrium
COSM1314711	c.1627C>T	p.L543L	Substitution - coding silent	Urinary_tract
COSM3906520	c.1151G>A	p.R384Q	Substitution - Missense	Stomach
COSM5948273	c.667_668ins18	p.Q223>PTAAAAE	Complex - insertion inframe	Haematopoietic_and_lymphoid_tissue
COSM1107775	c.3449C>A	p.P1150H	Substitution - Missense	Endometrium
COSM5942289	c.2037-5C>T	p.?	Unknown	Skin
COSM455755	c.2011G>C	p.E671Q	Substitution - Missense	Breast
COSM1664269	c.1810A>G	p.K604E	Substitution - Missense	Kidney
COSM4387143	c.3980G>A	p.R1327K	Substitution - Missense	Lung
COSM3906624	c.4204A>G	p.N1402D	Substitution - Missense	Stomach
COSM1107765	c.3218G>T	p.C1073F	Substitution - Missense	Endometrium
COSM1226748	c.3562G>A	p.A1188T	Substitution - Missense	Large_intestine
COSM1266220	c.3988G>A	p.E1330K	Substitution - Missense	Oesophagus
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Central_nervous_system
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Biliary_tract
COSM1107680	c.240A>G	p.I80M	Substitution - Missense	Endometrium
COSM3656608	c.4173C>T	p.I1391I	Substitution - coding silent	Large_intestine
COSM3906620	c.4150A>G	p.T1384A	Substitution - Missense	Stomach
COSM3091893	c.3485G>A	p.R1162H	Substitution - Missense	Large_intestine
COSM1226750	c.4045C>T	p.R1349*	Substitution - Nonsense	Large_intestine
COSM2156557	c.667_669delCAG	p.Q238delQ	Deletion - In frame	Skin
COSM277378	c.4261C>T	p.R1421*	Substitution - Nonsense	Liver
COSM1461795	c.4132C>T	p.P1378S	Substitution - Missense	Large_intestine
COSM4452835	c.2216A>G	p.Y739C	Substitution - Missense	Skin
COSM5472733	c.1305G>A	p.Q435Q	Substitution - coding silent	Large_intestine
COSM4748624	c.2078A>T	p.Y693F	Substitution - Missense	Stomach
COSM1107744	c.2927T>G	p.I976S	Substitution - Missense	Endometrium
COSM3926599	c.2975C>T	p.S992F	Substitution - Missense	Skin
COSM5977200	c.666_667insCAGCAGCAG	p.Q238_P239insQQQ	Insertion - In frame	Upper_aerodigestive_tract
COSM4776070	c.3605G>T	p.G1202V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5723957	c.1898C>T	p.S633F	Substitution - Missense	Skin
COSM5723957	c.1898C>T	p.S633F	Substitution - Missense	Skin
COSM1461743	c.3466G>A	p.A1156T	Substitution - Missense	Large_intestine
COSM5063849	c.3063G>A	p.M1021I	Substitution - Missense	Stomach
COSM4793343	c.3401A>C	p.N1134T	Substitution - Missense	Liver
COSM3091722	c.2041G>A	p.A681T	Substitution - Missense	Large_intestine
COSM1107702	c.1277C>A	p.A426D	Substitution - Missense	Endometrium
COSM4152232	c.2826A>C	p.L942F	Substitution - Missense	Ovary
COSM1636136	c.3445A>G	p.N1149D	Substitution - Missense	Liver
COSM3091667	c.1573C>T	p.R525C	Substitution - Missense	Bone
COSM3942993	c.321C>A	p.G107G	Substitution - coding silent	Oesophagus
COSM4728279	c.2990A>T	p.K997M	Substitution - Missense	Large_intestine
COSM3656509	c.2830C>T	p.P944S	Substitution - Missense	Skin
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Oesophagus
COSM1266212	c.3433G>C	p.D1145H	Substitution - Missense	Stomach
COSM5467663	c.2935C>T	p.R979C	Substitution - Missense	Large_intestine
COSM3780723	c.4432G>A	p.A1478T	Substitution - Missense	Pancreas
COSM1637489	c.3556G>A	p.A1186T	Substitution - Missense	Bone
COSM5483284	c.2649G>A	p.P883P	Substitution - coding silent	Large_intestine
COSM4805192	c.3452A>G	p.H1151R	Substitution - Missense	Liver
COSM218987	c.2759C>T	p.T920I	Substitution - Missense	Pancreas
COSM3765446	c.2648C>T	p.P883L	Substitution - Missense	Central_nervous_system
COSM3091901	c.3637C>T	p.R1213W	Substitution - Missense	Large_intestine
COSM277378	c.4261C>T	p.R1421*	Substitution - Nonsense	Large_intestine
COSM3656502	c.2233G>A	p.G745R	Substitution - Missense	Skin
COSM753794	c.2301G>A	p.M767I	Substitution - Missense	Lung
COSM3906512	c.744G>A	p.T248T	Substitution - coding silent	Stomach
COSM4789563	c.3464A>T	p.Q1155L	Substitution - Missense	Liver
COSM3092184	c.4027C>A	p.L1343I	Substitution - Missense	Large_intestine
COSM5643857	c.40G>A	p.G14R	Substitution - Missense	Oesophagus
COSM1624853	c.3485G>T	p.R1162L	Substitution - Missense	Liver
COSM353640	c.4207G>A	p.V1403M	Substitution - Missense	Lung
COSM355588	c.2430G>T	p.M810I	Substitution - Missense	Lung
COSM3750167	c.681G>A	p.Q227Q	Substitution - coding silent	Large_intestine
COSM3656492	c.1130C>T	p.T377I	Substitution - Missense	Skin
COSM1489898	c.1167G>T	p.Q389H	Substitution - Missense	Breast
COSM4728281	c.3864C>T	p.D1288D	Substitution - coding silent	Large_intestine
COSM3656483	c.434C>A	p.P145Q	Substitution - Missense	Skin
COSM5610600	c.4262G>T	p.R1421L	Substitution - Missense	Skin
COSM4519050	c.934_935CC>TA	p.P312*	Substitution - Nonsense	Skin
COSM1331609	c.2028G>A	p.Q676Q	Substitution - coding silent	Ovary
COSM455752	c.1450C>G	p.H484D	Substitution - Missense	Breast
COSM5649726	c.2348+1G>C	p.?	Unknown	Oesophagus
COSM4188339	c.2851A>G	p.K951E	Substitution - Missense	Kidney
COSM1107768	c.3232C>T	p.L1078F	Substitution - Missense	Endometrium
COSM4654489	c.574C>A	p.L192M	Substitution - Missense	Large_intestine
COSM338891	c.1358A>T	p.N453I	Substitution - Missense	Lung
COSM1658954	c.2564G>A	p.R855Q	Substitution - Missense	Large_intestine
COSM3848243	c.2853G>C	p.K951N	Substitution - Missense	Breast
COSM3926626	c.4256C>T	p.S1419L	Substitution - Missense	Skin
COSM3656485	c.472C>T	p.P158S	Substitution - Missense	Skin
COSM4844893	c.3783G>C	p.R1261R	Substitution - coding silent	Cervix
COSM5716253	c.531C>T	p.V177V	Substitution - coding silent	Skin
COSM1645004	c.3395G>T	p.G1132V	Substitution - Missense	Salivary_gland
COSM5459436	c.2774A>G	p.D925G	Substitution - Missense	Large_intestine
COSM1624855	c.3502G>A	p.E1168K	Substitution - Missense	Liver
COSM3091614	c.633G>A	p.T211T	Substitution - coding silent	Liver
COSM315431	c.3613G>T	p.D1205Y	Substitution - Missense	Lung
COSM3906527	c.1998C>T	p.S666S	Substitution - coding silent	Stomach
COSM4958267	c.2336T>C	p.I779T	Substitution - Missense	Liver
COSM3906534	c.2604C>A	p.N868K	Substitution - Missense	Stomach
COSM5610610	c.117C>T	p.S39S	Substitution - coding silent	Skin
COSM1107699	c.1150C>T	p.R384W	Substitution - Missense	Large_intestine
COSM4408969	c.4638C>G	p.D1546E	Substitution - Missense	Soft_tissue
COSM39777	c.1333C>T	p.R445C	Substitution - Missense	Central_nervous_system
COSM1266226	c.1079A>G	p.E360G	Substitution - Missense	Stomach
COSM3906584	c.3763C>T	p.R1255W	Substitution - Missense	Stomach
COSM4633063	c.668A>C	p.Q223P	Substitution - Missense	Large_intestine
COSM4535188	c.2164G>A	p.G722R	Substitution - Missense	Skin
COSM5520548	c.2469C>A	p.F823L	Substitution - Missense	Biliary_tract
COSM3656492	c.1130C>T	p.T377I	Substitution - Missense	Skin
COSM3906590	c.3894A>G	p.E1298E	Substitution - coding silent	Stomach
COSM5784623	c.3966G>A	p.E1322E	Substitution - coding silent	Breast
COSM4152232	c.2826A>C	p.L942F	Substitution - Missense	Ovary
COSM455760	c.2857G>A	p.E953K	Substitution - Missense	Breast
COSM3656487	c.501C>T	p.P167P	Substitution - coding silent	Skin
COSM1658954	c.2564G>A	p.R855Q	Substitution - Missense	Large_intestine
COSM4449990	c.4073_4075delAAG	p.E1359delE	Deletion - In frame	Skin
COSM1461719	c.2348C>T	p.S783L	Substitution - Missense	Bone
COSM4796011	c.3780G>A	p.R1260R	Substitution - coding silent	Liver
COSM4408969	c.4638C>G	p.D1546E	Substitution - Missense	Soft_tissue
COSM126316	c.2542A>T	p.M848L	Substitution - Missense	Upper_aerodigestive_tract
COSM218987	c.2759C>T	p.T920I	Substitution - Missense	Pancreas
COSM5653293	c.597C>A	p.P199P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM364119	c.4025G>T	p.R1342L	Substitution - Missense	Prostate
COSM4776070	c.3605G>T	p.G1202V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM400110	c.2110G>A	p.V704M	Substitution - Missense	Lung
COSM4833910	c.3583G>C	p.D1195H	Substitution - Missense	Cervix
COSM4833856	c.3940G>A	p.V1314M	Substitution - Missense	Cervix
COSM3848237	c.553C>T	p.Q185*	Substitution - Nonsense	Breast
COSM1331613	c.782G>A	p.R261K	Substitution - Missense	Ovary
COSM4853408	c.3186G>C	p.L1062F	Substitution - Missense	Cervix
COSM5610598	c.958C>T	p.Q320*	Substitution - Nonsense	Skin
COSM2151451	c.3292G>A	p.G1098S	Substitution - Missense	Central_nervous_system
COSM4163688	c.699G>A	p.Q233Q	Substitution - coding silent	Thyroid
COSM1314713	c.1680G>T	p.R560S	Substitution - Missense	Urinary_tract
COSM1107705	c.1399C>T	p.R467W	Substitution - Missense	Endometrium
COSM5700089	c.1066C>T	p.H356Y	Substitution - Missense	Soft_tissue
COSM1624855	c.3502G>A	p.E1168K	Substitution - Missense	Liver
COSM4456620	c.1016C>T	p.P339L	Substitution - Missense	Skin
COSM3092184	c.4027C>A	p.L1343I	Substitution - Missense	Large_intestine
COSM3788238	c.1935+2T>C	p.?	Unknown	Pancreas
COSM1569324	c.1489C>T	p.R497W	Substitution - Missense	Large_intestine
COSM6006004	c.1884A>T	p.E628D	Substitution - Missense	Small_intestine
COSM1645006	c.3490G>T	p.G1164W	Substitution - Missense	Salivary_gland
COSM4728275	c.1572G>A	p.R524R	Substitution - coding silent	Large_intestine
COSM5611390	c.1459_1460AC>TT	p.T487F	Substitution - Missense	Skin
COSM3906569	c.3557C>T	p.A1186V	Substitution - Missense	Stomach
COSM3763857	c.3672G>A	p.E1224E	Substitution - coding silent	Large_intestine
COSM315433	c.3201C>A	p.H1067Q	Substitution - Missense	Lung
COSM3906540	c.2883+2T>C	p.?	Unknown	Stomach
COSM5463789	c.2193C>T	p.G731G	Substitution - coding silent	Large_intestine
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Oesophagus
COSM3848239	c.705G>A	p.Q235Q	Substitution - coding silent	Large_intestine
COSM1624857	c.3559G>C	p.A1187P	Substitution - Missense	Liver
COSM3848247	c.3036G>A	p.L1012L	Substitution - coding silent	Breast
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Prostate
COSM4917274	c.1309A>G	p.K437E	Substitution - Missense	Liver
COSM1266218	c.669G>A	p.Q223Q	Substitution - coding silent	Ovary
COSM1569324	c.1489C>T	p.R497W	Substitution - Missense	Stomach
COSM4796011	c.3780G>A	p.R1260R	Substitution - coding silent	Liver
COSM247460	c.495C>T	p.S165S	Substitution - coding silent	Prostate
COSM3926622	c.4140C>T	p.P1380P	Substitution - coding silent	Skin
COSM3716168	c.1989T>G	p.D663E	Substitution - Missense	Upper_aerodigestive_tract
COSM1107696	c.1132G>T	p.V378L	Substitution - Missense	Stomach
COSM5805683	c.674A>T	p.Q225L	Substitution - Missense	Liver
COSM1107817	c.3925C>T	p.R1309C	Substitution - Missense	Breast
COSM1107731	c.2659A>G	p.K887E	Substitution - Missense	Endometrium
COSM1659603	c.624G>C	p.G208G	Substitution - coding silent	Kidney
COSM1107699	c.1150C>T	p.R384W	Substitution - Missense	Endometrium
COSM3091901	c.3637C>T	p.R1213W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4793343	c.3401A>C	p.N1134T	Substitution - Missense	Liver
COSM4408969	c.4638C>G	p.D1546E	Substitution - Missense	Liver
COSM4728271	c.708A>G	p.Q236Q	Substitution - coding silent	Large_intestine
COSM1624851	c.2983G>C	p.D995H	Substitution - Missense	Liver
COSM291298	c.1057C>T	p.R353C	Substitution - Missense	Large_intestine
COSM4791566	c.2123T>C	p.I708T	Substitution - Missense	Liver
COSM455766	c.3680A>G	p.N1227S	Substitution - Missense	Breast
COSM1659023	c.4582T>A	p.S1528T	Substitution - Missense	Salivary_gland
COSM3664280	c.657G>A	p.Q219Q	Substitution - coding silent	Liver
COSM1461691	c.683A>C	p.Q228P	Substitution - Missense	Upper_aerodigestive_tract
COSM4493339	c.4139C>T	p.P1380L	Substitution - Missense	Skin
COSM5729433	c.4199+1G>A	p.?	Unknown	Skin
COSM3091747	c.2345T>C	p.L782P	Substitution - Missense	Large_intestine
COSM277376	c.3490G>A	p.G1164R	Substitution - Missense	Large_intestine
COSM1461719	c.2348C>T	p.S783L	Substitution - Missense	Large_intestine
COSM1319617	c.2257C>T	p.L753F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5610604	c.4589C>T	p.S1530F	Substitution - Missense	Skin
COSM241694	c.304C>G	p.P102A	Substitution - Missense	Prostate
COSM3656571	c.3852C>T	p.I1284I	Substitution - coding silent	Skin
COSM1658954	c.2564G>A	p.R855Q	Substitution - Missense	Salivary_gland
COSM4854912	c.2554G>A	p.E852K	Substitution - Missense	Cervix
COSM3906530	c.2451G>A	p.Q817Q	Substitution - coding silent	Stomach
COSM1107820	c.3971A>G	p.Q1324R	Substitution - Missense	Endometrium
COSM5712482	c.4257A>C	p.S1419S	Substitution - coding silent	Central_nervous_system
COSM753784	c.3657C>T	p.A1219A	Substitution - coding silent	Lung
COSM3996490	c.3351C>T	p.S1117S	Substitution - coding silent	Kidney
COSM1107784	c.3560C>T	p.A1187V	Substitution - Missense	Endometrium
COSM5063847	c.2253G>T	p.M751I	Substitution - Missense	Stomach
COSM3779924	c.1269G>C	p.L423L	Substitution - coding silent	Urinary_tract
COSM5426962	c.704A>C	p.Q235P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5998224	c.1046+6G>A	p.?	Unknown	Prostate
COSM3664280	c.657G>A	p.Q219Q	Substitution - coding silent	Liver
COSM5757357	c.4085A>G	p.E1362G	Substitution - Missense	Large_intestine
COSM353638	c.3892G>T	p.E1298*	Substitution - Nonsense	Lung
COSM1659007	c.3476G>T	p.R1159L	Substitution - Missense	Salivary_gland
COSM1266216	c.666A>G	p.Q222Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM5640818	c.3742G>C	p.E1248Q	Substitution - Missense	Oesophagus

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
25712539	Mutation	B cell Lymphoma	Here, we performed bacterial artificial chromosome capture sequencing on three archival, formalin-fixed, paraffin-embedded tissue biopsies, interrogating 20 known rearrangement hotspots in B cell lymphomas. We report novel CIITA, FOXP1 and PDL rearrangements involving IGHG4, FLJ45248, RFX3, SMARCA2 and SNX29.
25561201	Mutation	Squamous Cell Carcinoma	Mutations in key genes, including TP53, BRM, PTCH1, and HRAS, contribute to skin carcinogenesis.
25496315	Mutation; Loss of Expression	Malignant rhabdoid tumor	Complete loss of SMARCB1, SMARCA2 and PBRM1 expression and corresponding mutations in the same genes were observed in all cases. The mutations included seven missense, three same-sense, four frameshift and two truncating mutations.
25462860	Mutation	Gastric Carcinoma	Moreover, somatic mutations of additional chromatin remodelers, such as ARID1A, SMARCA2, and SMARCA4, were found in 30% of gastric cancers.
23685749	Mutation	Adenoid cystic carcinoma	Notably, we found mutations in genes encoding chromatin-state regulators, such as SMARCA2, CREBBP and KDM6A, suggesting that there is aberrant epigenetic regulation in ACC oncogenesis.
23276717	Mutation	Oligodendroglioma	Our findings suggest that genetic variants in SMARCA2 and SMARCA4 influence the risk of oligodendroglioma.
28296015	Mutation	Hepatocellular Carcinoma	Specific patterns of gene mutations including CTNNB1, TERT, ARID1A and SMARCA2 exist in alcohol-related HCC.
27784745	Mutation	Acute Myeloid Leukemia	Novel recurrent mutational events in AML were identified in the SMARCA2 gene.

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P51531	175	S	Phosphoserine	-	No	None detected
P51531	316	S	Phosphoserine	-	No	None detected
P51531	329	S	Phosphoserine	-	No	None detected
P51531	591	S	Phosphoserine	-	No	None detected
P51531	604	K	N6-acetyllysine	-	No	None detected
P51531	666	S	Phosphoserine	-	Yes	p.S666R (cancer: HNSC)
P51531	997	K	N6-acetyllysine	-	Yes	p.997_998KG>NR (cancer: LIHC)
P51531	999	K	N6-acetyllysine	-	No	None detected
P51531	1377	S	Phosphoserine	-	No	None detected
P51531	1512	S	Phosphoserine	-	No	None detected
P51531	1516	S	Phosphoserine	-	No	None detected
P51531	1528	S	Phosphoserine	-	No	None detected
P51531	1568	S	Phosphoserine	-	No	None detected
P51531	1572	S	Phosphoserine	-	No	None detected

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.245	6.247	-0.973	1.93e-06	Under
BRCA	Breast invasive carcinoma	112	1100	8.019	7.303	-0.775	2.32e-33	Under
CESC	Cervical and endocervical cancers	3	306	7.19	6.427	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.93	6.255	-0.683	2.22e-09	Under
ESCA	Esophageal carcinoma	11	185	6.945	6.252	-0.783	0.00917	Under
GBM	Glioblastoma multiforme	5	166	8.016	6.472	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.908	6.047	-0.821	3.31e-08	Under
KIRC	Kidney renal clear cell carcinoma	72	534	7.833	6.855	-1.003	2.24e-44	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	7.532	6.594	-1.082	1.56e-18	Under
LAML	Acute Myeloid Leukemia	0	173	NA	7.871	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.239	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.432	5.499	-1.06	1.31e-11	Under
LUAD	Lung adenocarcinoma	59	517	7.35	6.204	-1.097	6.12e-25	Under
LUSC	Lung squamous cell carcinoma	51	501	7.264	6.36	-0.792	1.03e-07	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.803	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.9	6.663	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.225	7.188	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.45	7.194	-0.347	2.54e-05	NS
READ	Rectum adenocarcinoma	10	167	7.013	6.382	-0.678	0.012	Under
SARC	Sarcoma	2	263	6.903	6.959	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.997	6.178	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.765	6.283	-0.674	1.76e-05	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.947	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.905	7.086	-0.762	1.97e-26	Under
THYM	Thymoma	2	120	7.141	6.856	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.419	5.861	-1.666	8.4e-20	Under

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.2
Autonomic ganglia	CHP212	7.2
Autonomic ganglia	IMR32	7.2
Autonomic ganglia	KELLY	4.2
Autonomic ganglia	KPNRTBM1	7.1
Autonomic ganglia	KPNSI9S	6.7
Autonomic ganglia	KPNYN	7.4
Autonomic ganglia	MHHNB11	4.3
Autonomic ganglia	NB1	7.1
Autonomic ganglia	NH6	7
Autonomic ganglia	SHSY5Y	7.2
Autonomic ganglia	SIMA	5.9
Autonomic ganglia	SKNAS	4.7
Autonomic ganglia	SKNBE2	8
Autonomic ganglia	SKNDZ	4.9
Autonomic ganglia	SKNFI	4.7
Autonomic ganglia	SKNSH	6.3
Biliary tract	HUCCT1	7
Biliary tract	HUH28	6.7
Biliary tract	SNU1079	6.4
Biliary tract	SNU1196	6.7
Biliary tract	SNU245	7.4
Biliary tract	SNU308	6.5
Biliary tract	SNU478	6.4
Bone	143B	6.9
Bone	A673	7.8
Bone	CADOES1	8.3
Bone	CAL78	6.7
Bone	G292CLONEA141B1	6.2
Bone	HOS	5.9
Bone	HS706T	7.5
Bone	HS737T	7.3
Bone	HS819T	7.4
Bone	HS821T	7.9
Bone	HS822T	7.7
Bone	HS863T	8.3
Bone	HS870T	7.1
Bone	HS888T	8.5
Bone	MG63	7.3
Bone	MHHES1	8.5
Bone	OUMS27	6.9
Bone	RDES	4.7
Bone	SJSA1	6.7
Bone	SKES1	7.2
Bone	SKNMC	7.5
Bone	SW1353	7.2
Bone	T173	7.6
Bone	TC71	5.9
Bone	U2OS	6.7
Breast	AU565	4.9
Breast	BT20	8.3
Breast	BT474	6.6
Breast	BT483	8.2
Breast	BT549	5.4
Breast	CAL120	7.3
Breast	CAL148	8.3
Breast	CAL51	7.4
Breast	CAL851	7.4
Breast	CAMA1	8.1
Breast	DU4475	8.6
Breast	EFM192A	6.8
Breast	EFM19	6.1
Breast	EVSAT	7.2
Breast	HCC1143	4.4
Breast	HCC1187	8.7
Breast	HCC1395	9.1
Breast	HCC1419	8.9
Breast	HCC1428	7.5
Breast	HCC1500	7.7
Breast	HCC1569	8.3
Breast	HCC1599	7.5
Breast	HCC1806	6.9
Breast	HCC1937	8.1
Breast	HCC1954	8.9
Breast	HCC202	8.3
Breast	HCC2157	9
Breast	HCC2218	7.3
Breast	HCC38	7.3
Breast	HCC70	9.5
Breast	HDQP1	7.2
Breast	HMC18	4.5
Breast	HS274T	8.6
Breast	HS281T	8.4
Breast	HS343T	8.4
Breast	HS578T	7.2
Breast	HS606T	7.9
Breast	HS739T	7.7
Breast	HS742T	7.6
Breast	JIMT1	8.1
Breast	KPL1	8
Breast	MCF7	7.4
Breast	MDAMB134VI	7.6
Breast	MDAMB157	6.7
Breast	MDAMB175VII	7.5
Breast	MDAMB231	7.3
Breast	MDAMB361	6.8
Breast	MDAMB415	8.7
Breast	MDAMB436	8.6
Breast	MDAMB453	7.8
Breast	MDAMB468	7.1
Breast	SKBR3	5.8
Breast	T47D	6.6
Breast	UACC812	7.3
Breast	UACC893	7.7
Breast	YMB1	8.3
Breast	ZR751	6.9
Breast	ZR7530	9.4
Central nervous system	1321N1	7.6
Central nervous system	42MGBA	8.4
Central nervous system	8MGBA	7.8
Central nervous system	A172	7.7
Central nervous system	AM38	6.9
Central nervous system	BECKER	6.8
Central nervous system	CAS1	6.9
Central nervous system	CCFSTTG1	7.7
Central nervous system	D283MED	6.4
Central nervous system	D341MED	7.8
Central nervous system	DAOY	8.5
Central nervous system	DBTRG05MG	8.3
Central nervous system	DKMG	7.1
Central nervous system	GAMG	6.8
Central nervous system	GB1	7.9
Central nervous system	GI1	7
Central nervous system	GMS10	7.4
Central nervous system	GOS3	9
Central nervous system	H4	7.4
Central nervous system	HS683	7
Central nervous system	KALS1	7.9
Central nervous system	KG1C	8.6
Central nervous system	KNS42	8.1
Central nervous system	KNS60	7.9
Central nervous system	KNS81	8.5
Central nervous system	KS1	8
Central nervous system	LN18	6.9
Central nervous system	LN229	8
Central nervous system	M059K	7.7
Central nervous system	MOGGCCM	8.9
Central nervous system	MOGGUVW	8.1
Central nervous system	NMCG1	7.5
Central nervous system	ONS76	6.4
Central nervous system	SF126	6.2
Central nervous system	SF295	7.7
Central nervous system	SNB19	8
Central nervous system	SNU1105	8.2
Central nervous system	SNU201	8.4
Central nervous system	SNU466	6.5
Central nervous system	SNU489	9.3
Central nervous system	SNU626	9.2
Central nervous system	SNU738	5.9
Central nervous system	SW1088	7
Central nervous system	SW1783	7.4
Central nervous system	T98G	7.7
Central nervous system	TM31	7.4
Central nervous system	U118MG	7.8
Central nervous system	U138MG	8.2
Central nervous system	U251MG	8.5
Central nervous system	U87MG	7.8
Central nervous system	YH13	8
Central nervous system	YKG1	8.8
Endometrium	AN3CA	7
Endometrium	COLO684	6.9
Endometrium	EFE184	6.2
Endometrium	EN	6.9
Endometrium	ESS1	7.4
Endometrium	HEC108	6.6
Endometrium	HEC151	6.4
Endometrium	HEC1A	8
Endometrium	HEC1B	9.3
Endometrium	HEC251	5.4
Endometrium	HEC265	6.6
Endometrium	HEC50B	6.2
Endometrium	HEC59	6.6
Endometrium	HEC6	7.9
Endometrium	ISHIKAWAHERAKLIO02ER	7.1
Endometrium	JHUEM1	6.2
Endometrium	JHUEM2	9.8
Endometrium	JHUEM3	7.7
Endometrium	KLE	5.9
Endometrium	MFE280	6.9
Endometrium	MFE296	7.2
Endometrium	MFE319	7
Endometrium	RL952	7
Endometrium	SNGM	6.4
Endometrium	SNU1077	6.7
Endometrium	SNU685	6.3
Endometrium	TEN	4.5
Haematopoietic and lymphoid	697	9
Haematopoietic and lymphoid	A3KAW	7.7
Haematopoietic and lymphoid	A4FUK	7.1
Haematopoietic and lymphoid	ALLSIL	8.4
Haematopoietic and lymphoid	AML193	8.4
Haematopoietic and lymphoid	AMO1	8.9
Haematopoietic and lymphoid	BCP1	7.2
Haematopoietic and lymphoid	BDCM	10.7
Haematopoietic and lymphoid	BL41	8
Haematopoietic and lymphoid	BL70	6.5
Haematopoietic and lymphoid	BV173	8.8
Haematopoietic and lymphoid	CA46	8.2
Haematopoietic and lymphoid	CI1	7.8
Haematopoietic and lymphoid	CMK115	8
Haematopoietic and lymphoid	CMK86	8.8
Haematopoietic and lymphoid	CMK	9.3
Haematopoietic and lymphoid	CMLT1	9.5
Haematopoietic and lymphoid	COLO775	9.3
Haematopoietic and lymphoid	DAUDI	8.8
Haematopoietic and lymphoid	DB	6.9
Haematopoietic and lymphoid	DEL	8.1
Haematopoietic and lymphoid	DND41	8.5
Haematopoietic and lymphoid	DOHH2	9.1
Haematopoietic and lymphoid	EB1	8.2
Haematopoietic and lymphoid	EB2	8.8
Haematopoietic and lymphoid	EHEB	9.5
Haematopoietic and lymphoid	EJM	9.9
Haematopoietic and lymphoid	EM2	9.6
Haematopoietic and lymphoid	EOL1	8.6
Haematopoietic and lymphoid	F36P	10.3
Haematopoietic and lymphoid	GA10	7.7
Haematopoietic and lymphoid	GDM1	8.7
Haematopoietic and lymphoid	GRANTA519	9.3
Haematopoietic and lymphoid	HDLM2	11.4
Haematopoietic and lymphoid	HDMYZ	7.6
Haematopoietic and lymphoid	HEL9217	9.2
Haematopoietic and lymphoid	HEL	10.2
Haematopoietic and lymphoid	HH	10.7
Haematopoietic and lymphoid	HL60	9.5
Haematopoietic and lymphoid	HPBALL	7.3
Haematopoietic and lymphoid	HS604T	7.5
Haematopoietic and lymphoid	HS611T	8.7
Haematopoietic and lymphoid	HS616T	7.6
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	7.5
Haematopoietic and lymphoid	HTK	7.7
Haematopoietic and lymphoid	HUNS1	9.2
Haematopoietic and lymphoid	HUT102	9.1
Haematopoietic and lymphoid	HUT78	9.1
Haematopoietic and lymphoid	JEKO1	7.3
Haematopoietic and lymphoid	JK1	8.5
Haematopoietic and lymphoid	JM1	8
Haematopoietic and lymphoid	JURKAT	8.5
Haematopoietic and lymphoid	JURLMK1	7.8
Haematopoietic and lymphoid	JVM2	9.3
Haematopoietic and lymphoid	JVM3	10.6
Haematopoietic and lymphoid	K562	6.7
Haematopoietic and lymphoid	KARPAS299	8
Haematopoietic and lymphoid	KARPAS422	9.2
Haematopoietic and lymphoid	KARPAS620	8.4
Haematopoietic and lymphoid	KASUMI1	8
Haematopoietic and lymphoid	KASUMI2	9.3
Haematopoietic and lymphoid	KASUMI6	9.7
Haematopoietic and lymphoid	KCL22	10.1
Haematopoietic and lymphoid	KE37	8.1
Haematopoietic and lymphoid	KE97	9.3
Haematopoietic and lymphoid	KG1	9
Haematopoietic and lymphoid	KHM1B	7.7
Haematopoietic and lymphoid	KIJK	6.7
Haematopoietic and lymphoid	KMH2	10.2
Haematopoietic and lymphoid	KMM1	7
Haematopoietic and lymphoid	KMS11	9.5
Haematopoietic and lymphoid	KMS12BM	8.6
Haematopoietic and lymphoid	KMS18	10.1
Haematopoietic and lymphoid	KMS20	6.9
Haematopoietic and lymphoid	KMS21BM	7.3
Haematopoietic and lymphoid	KMS26	8.7
Haematopoietic and lymphoid	KMS27	8.4
Haematopoietic and lymphoid	KMS28BM	7.8
Haematopoietic and lymphoid	KMS34	7.9
Haematopoietic and lymphoid	KO52	9.3
Haematopoietic and lymphoid	KOPN8	9.3
Haematopoietic and lymphoid	KU812	9
Haematopoietic and lymphoid	KYO1	7.2
Haematopoietic and lymphoid	L1236	9.8
Haematopoietic and lymphoid	L363	7.8
Haematopoietic and lymphoid	L428	11.8
Haematopoietic and lymphoid	L540	6.8
Haematopoietic and lymphoid	LAMA84	8.4
Haematopoietic and lymphoid	LOUCY	8.8
Haematopoietic and lymphoid	LP1	9.6
Haematopoietic and lymphoid	M07E	9.8
Haematopoietic and lymphoid	MC116	8.4
Haematopoietic and lymphoid	ME1	9.9
Haematopoietic and lymphoid	MEC1	10.4
Haematopoietic and lymphoid	MEC2	10.6
Haematopoietic and lymphoid	MEG01	6.5
Haematopoietic and lymphoid	MHHCALL2	9.3
Haematopoietic and lymphoid	MHHCALL3	8.6
Haematopoietic and lymphoid	MHHCALL4	9.6
Haematopoietic and lymphoid	MINO	8.1
Haematopoietic and lymphoid	MJ	10.2
Haematopoietic and lymphoid	MM1S	9
Haematopoietic and lymphoid	MOLM13	9.1
Haematopoietic and lymphoid	MOLM16	10.6
Haematopoietic and lymphoid	MOLM6	10.3
Haematopoietic and lymphoid	MOLP2	8.1
Haematopoietic and lymphoid	MOLP8	9.2
Haematopoietic and lymphoid	MOLT13	8.3
Haematopoietic and lymphoid	MOLT16	8.9
Haematopoietic and lymphoid	MOLT4	7.3
Haematopoietic and lymphoid	MONOMAC1	9.6
Haematopoietic and lymphoid	MONOMAC6	8.8
Haematopoietic and lymphoid	MOTN1	10.3
Haematopoietic and lymphoid	MUTZ5	9.8
Haematopoietic and lymphoid	MV411	8.1
Haematopoietic and lymphoid	NALM19	8.8
Haematopoietic and lymphoid	NALM1	8.4
Haematopoietic and lymphoid	NALM6	9.5
Haematopoietic and lymphoid	NAMALWA	8
Haematopoietic and lymphoid	NB4	8.8
Haematopoietic and lymphoid	NCIH929	7.7
Haematopoietic and lymphoid	NCO2	8.9
Haematopoietic and lymphoid	NOMO1	7.8
Haematopoietic and lymphoid	NUDHL1	9.2
Haematopoietic and lymphoid	NUDUL1	9.8
Haematopoietic and lymphoid	OCIAML2	10.1
Haematopoietic and lymphoid	OCIAML3	8.2
Haematopoietic and lymphoid	OCIAML5	10.8
Haematopoietic and lymphoid	OCILY10	8.2
Haematopoietic and lymphoid	OCILY19	8.9
Haematopoietic and lymphoid	OCILY3	9.2
Haematopoietic and lymphoid	OCIM1	9.1
Haematopoietic and lymphoid	OPM2	9.5
Haematopoietic and lymphoid	P12ICHIKAWA	6.7
Haematopoietic and lymphoid	P31FUJ	9
Haematopoietic and lymphoid	P3HR1	7.6
Haematopoietic and lymphoid	PCM6	10.2
Haematopoietic and lymphoid	PEER	7.6
Haematopoietic and lymphoid	PF382	8.6
Haematopoietic and lymphoid	PFEIFFER	8.5
Haematopoietic and lymphoid	PL21	9.1
Haematopoietic and lymphoid	RAJI	7.8
Haematopoietic and lymphoid	RCHACV	9.6
Haematopoietic and lymphoid	REC1	7.9
Haematopoietic and lymphoid	REH	9
Haematopoietic and lymphoid	RI1	8.2
Haematopoietic and lymphoid	RL	7.2
Haematopoietic and lymphoid	RPMI8226	9.2
Haematopoietic and lymphoid	RPMI8402	7
Haematopoietic and lymphoid	RS411	9.5
Haematopoietic and lymphoid	SEM	9.6
Haematopoietic and lymphoid	SET2	9.8
Haematopoietic and lymphoid	SIGM5	8.7
Haematopoietic and lymphoid	SKM1	8.5
Haematopoietic and lymphoid	SKMM2	8.3
Haematopoietic and lymphoid	SR786	7.5
Haematopoietic and lymphoid	ST486	7.6
Haematopoietic and lymphoid	SUDHL10	8.8
Haematopoietic and lymphoid	SUDHL1	6.9
Haematopoietic and lymphoid	SUDHL4	8.6
Haematopoietic and lymphoid	SUDHL5	9.3
Haematopoietic and lymphoid	SUDHL6	8.5
Haematopoietic and lymphoid	SUDHL8	8.9
Haematopoietic and lymphoid	SUPB15	8.4
Haematopoietic and lymphoid	SUPHD1	10.4
Haematopoietic and lymphoid	SUPM2	7
Haematopoietic and lymphoid	SUPT11	9.4
Haematopoietic and lymphoid	SUPT1	6.9
Haematopoietic and lymphoid	TALL1	7.4
Haematopoietic and lymphoid	TF1	7.9
Haematopoietic and lymphoid	THP1	9.2
Haematopoietic and lymphoid	TO175T	7.1
Haematopoietic and lymphoid	TOLEDO	7.8
Haematopoietic and lymphoid	U266B1	7.9
Haematopoietic and lymphoid	U937	7.9
Haematopoietic and lymphoid	UT7	12.4
Haematopoietic and lymphoid	WSUDLCL2	8.9
Kidney	769P	7.7
Kidney	786O	8
Kidney	A498	7.7
Kidney	A704	5.6
Kidney	ACHN	7.5
Kidney	BFTC909	10.2
Kidney	CAKI1	7.2
Kidney	CAKI2	6.8
Kidney	CAL54	7.8
Kidney	KMRC1	7.4
Kidney	KMRC20	6.9
Kidney	KMRC2	6.6
Kidney	KMRC3	6.2
Kidney	OSRC2	7
Kidney	RCC10RGB	7.2
Kidney	SNU1272	8
Kidney	SNU349	6.9
Kidney	TUHR10TKB	7.3
Kidney	TUHR14TKB	8.9
Kidney	TUHR4TKB	7.2
Kidney	VMRCRCW	7.1
Kidney	VMRCRCZ	7.4
Large intestine	C2BBE1	4.2
Large intestine	CCK81	6.4
Large intestine	CL11	8.2
Large intestine	CL14	6.8
Large intestine	CL34	8.6
Large intestine	CL40	7.2
Large intestine	COLO205	7.8
Large intestine	COLO320	7.3
Large intestine	COLO678	8.5
Large intestine	CW2	8.2
Large intestine	DLD1	7.5
Large intestine	GP2D	5.7
Large intestine	HCC56	7.9
Large intestine	HCT116	5.3
Large intestine	HCT15	7.4
Large intestine	HS675T	7.1
Large intestine	HS698T	8.8
Large intestine	HT115	7.8
Large intestine	HT29	7.3
Large intestine	HT55	7.6
Large intestine	KM12	7.6
Large intestine	LOVO	7
Large intestine	LS1034	7
Large intestine	LS123	7.4
Large intestine	LS180	8.4
Large intestine	LS411N	8
Large intestine	LS513	7.8
Large intestine	MDST8	7.8
Large intestine	NCIH508	7.4
Large intestine	NCIH716	5.8
Large intestine	NCIH747	7.7
Large intestine	OUMS23	8.4
Large intestine	RCM1	6
Large intestine	RKO	6.6
Large intestine	SKCO1	3.9
Large intestine	SNU1040	7.3
Large intestine	SNU1197	7.4
Large intestine	SNU175	8.6
Large intestine	SNU283	8.8
Large intestine	SNU407	7.5
Large intestine	SNU503	8.5
Large intestine	SNU61	7.4
Large intestine	SNU81	8
Large intestine	SNUC1	7.6
Large intestine	SNUC2A	7.7
Large intestine	SNUC4	8
Large intestine	SNUC5	7.3
Large intestine	SW1116	5.3
Large intestine	SW1417	7.2
Large intestine	SW1463	7.4
Large intestine	SW403	8.3
Large intestine	SW480	6.3
Large intestine	SW48	8.6
Large intestine	SW620	7.2
Large intestine	SW837	6.3
Large intestine	SW948	7.5
Large intestine	T84	5.5
Liver	ALEXANDERCELLS	5
Liver	C3A	6.8
Liver	HEP3B217	6.1
Liver	HEPG2	6.9
Liver	HLE	6.5
Liver	HLF	6
Liver	HUH1	5.6
Liver	HUH6	4.9
Liver	HUH7	4
Liver	JHH1	4.4
Liver	JHH2	6.3
Liver	JHH4	3.9
Liver	JHH5	5.2
Liver	JHH6	8
Liver	JHH7	6.1
Liver	LI7	7.9
Liver	PLCPRF5	4.6
Liver	SKHEP1	6.8
Liver	SNU182	8.2
Liver	SNU387	7.3
Liver	SNU398	4.8
Liver	SNU423	7.3
Liver	SNU449	5.9
Liver	SNU475	6.3
Liver	SNU761	7.6
Liver	SNU878	6.8
Liver	SNU886	6.5
Lung	A549	6.5
Lung	ABC1	7.2
Lung	BEN	7.2
Lung	CAL12T	6.7
Lung	CALU1	7.2
Lung	CALU3	6.9
Lung	CALU6	5.7
Lung	CHAGOK1	6.2
Lung	COLO668	8.5
Lung	COLO699	7.1
Lung	CORL105	7.1
Lung	CORL23	7.5
Lung	CORL24	7.9
Lung	CORL279	7.8
Lung	CORL311	7.2
Lung	CORL47	8.1
Lung	CORL51	7
Lung	CORL88	7.4
Lung	CORL95	8.8
Lung	CPCN	7.5
Lung	DMS114	4.1
Lung	DMS153	7
Lung	DMS273	8
Lung	DMS454	6.9
Lung	DMS53	5.5
Lung	DMS79	5.5
Lung	DV90	7.4
Lung	EBC1	6.1
Lung	EPLC272H	6.4
Lung	HARA	7.3
Lung	HCC1171	6.9
Lung	HCC1195	4.2
Lung	HCC15	7
Lung	HCC2279	5.5
Lung	HCC2935	8.6
Lung	HCC33	8.2
Lung	HCC366	6.9
Lung	HCC4006	9.4
Lung	HCC44	6.4
Lung	HCC78	8
Lung	HCC827	7.3
Lung	HCC95	7.9
Lung	HLC1	4.9
Lung	HLFA	7.5
Lung	HS229T	7
Lung	HS618T	7.2
Lung	IALM	7.4
Lung	KNS62	7.7
Lung	LC1F	8.3
Lung	LC1SQSF	8.5
Lung	LCLC103H	9.8
Lung	LCLC97TM1	7.3
Lung	LK2	6.4
Lung	LOUNH91	7
Lung	LU65	7.5
Lung	LU99	7.9
Lung	LUDLU1	5.7
Lung	LXF289	8.4
Lung	MORCPR	5
Lung	NCIH1048	7.2
Lung	NCIH1092	4.6
Lung	NCIH1105	5.8
Lung	NCIH1155	7.5
Lung	NCIH1184	6.5
Lung	NCIH1299	5
Lung	NCIH1339	7.8
Lung	NCIH1341	5.6
Lung	NCIH1355	5.3
Lung	NCIH1373	6.6
Lung	NCIH1385	7.1
Lung	NCIH1395	8
Lung	NCIH1435	7.5
Lung	NCIH1436	7.2
Lung	NCIH1437	6.7
Lung	NCIH146	7
Lung	NCIH1563	7.9
Lung	NCIH1568	6.3
Lung	NCIH1573	6.2
Lung	NCIH1581	3.8
Lung	NCIH1618	7.6
Lung	NCIH1623	5.4
Lung	NCIH1648	5.2
Lung	NCIH1650	7.1
Lung	NCIH1651	5.8
Lung	NCIH1666	6
Lung	NCIH1693	5.8
Lung	NCIH1694	7.2
Lung	NCIH1703	3.9
Lung	NCIH1734	5.5
Lung	NCIH1755	5.7
Lung	NCIH1781	5.3
Lung	NCIH1792	6.5
Lung	NCIH1793	7.6
Lung	NCIH1836	6.8
Lung	NCIH1838	5.3
Lung	NCIH1869	7.7
Lung	NCIH1876	8.8
Lung	NCIH1915	6.9
Lung	NCIH1930	5.7
Lung	NCIH1944	7.1
Lung	NCIH1963	7.5
Lung	NCIH196	8.3
Lung	NCIH1975	6.5
Lung	NCIH2009	7.4
Lung	NCIH2023	5.5
Lung	NCIH2029	6.6
Lung	NCIH2030	5.1
Lung	NCIH2066	5.7
Lung	NCIH2081	8.2
Lung	NCIH2085	6.6
Lung	NCIH2087	5.5
Lung	NCIH209	7.2
Lung	NCIH2106	8.6
Lung	NCIH2110	7.2
Lung	NCIH211	8.3
Lung	NCIH2122	7.8
Lung	NCIH2126	6.4
Lung	NCIH2141	6.8
Lung	NCIH2170	7.9
Lung	NCIH2171	7.9
Lung	NCIH2172	7.1
Lung	NCIH2196	8.1
Lung	NCIH2227	5.8
Lung	NCIH2228	6.8
Lung	NCIH226	6.7
Lung	NCIH2286	4.8
Lung	NCIH2291	5.7
Lung	NCIH2342	6.1
Lung	NCIH2347	4.7
Lung	NCIH23	4.5
Lung	NCIH2405	5.7
Lung	NCIH2444	6
Lung	NCIH292	7.6
Lung	NCIH322	6.2
Lung	NCIH3255	4.7
Lung	NCIH358	6.7
Lung	NCIH441	7.2
Lung	NCIH446	9
Lung	NCIH460	7.2
Lung	NCIH510	5.9
Lung	NCIH520	6.3
Lung	NCIH522	3.8
Lung	NCIH524	7.8
Lung	NCIH526	7.3
Lung	NCIH596	7.8
Lung	NCIH647	6.9
Lung	NCIH650	4.9
Lung	NCIH661	4.9
Lung	NCIH69	6.5
Lung	NCIH727	5.9
Lung	NCIH810	6.2
Lung	NCIH82	4.8
Lung	NCIH838	7.6
Lung	NCIH841	4
Lung	NCIH854	6.1
Lung	NCIH889	8.9
Lung	PC14	6.8
Lung	RERFLCAD1	7.2
Lung	RERFLCAD2	6
Lung	RERFLCAI	6.5
Lung	RERFLCKJ	7.3
Lung	RERFLCMS	6.7
Lung	RERFLCSQ1	7.7
Lung	SBC5	4.1
Lung	SCLC21H	8.2
Lung	SHP77	6.7
Lung	SKLU1	7.3
Lung	SKMES1	8
Lung	SQ1	5.4
Lung	SW1271	5.6
Lung	SW1573	8
Lung	SW900	7.2
Lung	VMRCLCD	6.2
Lung	VMRCLCP	4
Oesophagus	COLO680N	4.8
Oesophagus	ECGI10	8.2
Oesophagus	KYSE140	7.4
Oesophagus	KYSE150	6.9
Oesophagus	KYSE180	6
Oesophagus	KYSE270	6.6
Oesophagus	KYSE30	4.1
Oesophagus	KYSE410	6.7
Oesophagus	KYSE450	7.7
Oesophagus	KYSE510	4.2
Oesophagus	KYSE520	6
Oesophagus	KYSE70	7.7
Oesophagus	OE19	7.3
Oesophagus	OE33	7.6
Oesophagus	TE10	5.5
Oesophagus	TE11	7.9
Oesophagus	TE14	7.3
Oesophagus	TE15	7.4
Oesophagus	TE1	4.3
Oesophagus	TE4	5.9
Oesophagus	TE5	6.6
Oesophagus	TE6	7.2
Oesophagus	TE8	7.2
Oesophagus	TE9	7
Oesophagus	TT	6.9
Ovary	59M	6.4
Ovary	A2780	4.3
Ovary	CAOV3	6.2
Ovary	CAOV4	6.8
Ovary	COLO704	6.7
Ovary	COV318	4.4
Ovary	COV362	7
Ovary	COV434	4.7
Ovary	COV504	7.6
Ovary	COV644	7.2
Ovary	EFO21	6.5
Ovary	EFO27	5.4
Ovary	ES2	7.2
Ovary	FUOV1	5.9
Ovary	HEYA8	7.6
Ovary	HS571T	8.1
Ovary	IGROV1	4.2
Ovary	JHOC5	6.6
Ovary	JHOM1	6.6
Ovary	JHOM2B	8.3
Ovary	JHOS2	6.5
Ovary	JHOS4	7.1
Ovary	KURAMOCHI	5.8
Ovary	MCAS	7.2
Ovary	NIHOVCAR3	6.7
Ovary	OAW28	7.9
Ovary	OAW42	5.1
Ovary	OC314	6.7
Ovary	OC316	6.8
Ovary	ONCODG1	7.7
Ovary	OV56	6.3
Ovary	OV7	7.9
Ovary	OV90	4.4
Ovary	OVCAR4	7.4
Ovary	OVCAR8	7.2
Ovary	OVISE	5.4
Ovary	OVK18	4.2
Ovary	OVKATE	7.2
Ovary	OVMANA	6.9
Ovary	OVSAHO	4.1
Ovary	OVTOKO	5.4
Ovary	RMGI	5.4
Ovary	RMUGS	5.3
Ovary	SKOV3	6.4
Ovary	SNU119	8
Ovary	SNU840	7
Ovary	SNU8	8.1
Ovary	TOV112D	4
Ovary	TOV21G	5.7
Ovary	TYKNU	7.1
Pancreas	ASPC1	7
Pancreas	BXPC3	6.4
Pancreas	CAPAN1	7
Pancreas	CAPAN2	6.7
Pancreas	CFPAC1	6.1
Pancreas	DANG	6.6
Pancreas	HPAC	7.2
Pancreas	HPAFII	5.7
Pancreas	HS766T	7.9
Pancreas	HUPT3	5.4
Pancreas	HUPT4	3.9
Pancreas	KCIMOH1	7.4
Pancreas	KLM1	6.8
Pancreas	KP2	7.6
Pancreas	KP3	7.3
Pancreas	KP4	4.2
Pancreas	L33	7.8
Pancreas	MIAPACA2	4.4
Pancreas	PANC0203	6.6
Pancreas	PANC0213	6.9
Pancreas	PANC0327	6.7
Pancreas	PANC0403	7.5
Pancreas	PANC0504	6.8
Pancreas	PANC0813	6.2
Pancreas	PANC1005	7.2
Pancreas	PANC1	5.4
Pancreas	PATU8902	4.5
Pancreas	PATU8988S	5.5
Pancreas	PATU8988T	6.8
Pancreas	PK1	6.6
Pancreas	PK45H	7.4
Pancreas	PK59	6.1
Pancreas	PL45	6.5
Pancreas	PSN1	6.8
Pancreas	QGP1	8.4
Pancreas	SNU213	6.1
Pancreas	SNU324	8.6
Pancreas	SNU410	6.1
Pancreas	SU8686	6.7
Pancreas	SUIT2	8.6
Pancreas	SW1990	5.7
Pancreas	T3M4	6.9
Pancreas	TCCPAN2	7.6
Pancreas	YAPC	6.3
Pleura	ACCMESO1	7.1
Pleura	DM3	7.7
Pleura	ISTMES1	4.2
Pleura	ISTMES2	7.6
Pleura	JL1	7.6
Pleura	MPP89	7
Pleura	MSTO211H	7.3
Pleura	NCIH2052	7.6
Pleura	NCIH2452	7.1
Pleura	NCIH28	5.4
Prostate	22RV1	8.4
Prostate	DU145	6.5
Prostate	LNCAPCLONEFGC	7.9
Prostate	MDAPCA2B	7.3
Prostate	NCIH660	7.2
Prostate	PC3	6.5
Prostate	VCAP	9.1
Salivary gland	A253	8.6
Salivary gland	YD15	6.9
Skin	A101D	6.4
Skin	A2058	7.5
Skin	A375	8
Skin	C32	7.2
Skin	CHL1	7.1
Skin	CJM	7.7
Skin	COLO679	6
Skin	COLO741	7.4
Skin	COLO783	8
Skin	COLO792	6.7
Skin	COLO800	7.5
Skin	COLO818	7.7
Skin	COLO829	8
Skin	COLO849	7.3
Skin	G361	6.9
Skin	GRM	7
Skin	HMCB	7.6
Skin	HS294T	7.1
Skin	HS600T	7.6
Skin	HS688AT	7.7
Skin	HS695T	7.9
Skin	HS839T	7.4
Skin	HS852T	6.9
Skin	HS895T	6.8
Skin	HS934T	8.8
Skin	HS936T	6.9
Skin	HS939T	7.2
Skin	HS940T	7.3
Skin	HS944T	6.6
Skin	HT144	6.2
Skin	IGR1	7.2
Skin	IGR37	6.8
Skin	IGR39	7.6
Skin	IPC298	7.5
Skin	K029AX	7
Skin	LOXIMVI	8
Skin	MALME3M	7.2
Skin	MDAMB435S	8.5
Skin	MELHO	7.1
Skin	MELJUSO	5.7
Skin	MEWO	6.6
Skin	RPMI7951	8.2
Skin	RVH421	7.4
Skin	SH4	8.1
Skin	SKMEL1	6.7
Skin	SKMEL24	6.9
Skin	SKMEL28	7.2
Skin	SKMEL2	7.3
Skin	SKMEL30	7
Skin	SKMEL31	7
Skin	SKMEL3	7.4
Skin	SKMEL5	7
Skin	UACC257	6.7
Skin	UACC62	6.7
Skin	WM115	6.2
Skin	WM1799	8.1
Skin	WM2664	7.4
Skin	WM793	7.6
Skin	WM88	6.6
Skin	WM983B	6
Small intestine	HUTU80	4.1
Soft tissue	A204	6.7
Soft tissue	G401	4.3
Soft tissue	G402	3.9
Soft tissue	GCT	7
Soft tissue	HS729	6.2
Soft tissue	HT1080	7
Soft tissue	KYM1	4.1
Soft tissue	MESSA	7.6
Soft tissue	RD	4.7
Soft tissue	RH30	6.9
Soft tissue	RH41	7.7
Soft tissue	RKN	7.4
Soft tissue	S117	9.2
Soft tissue	SJRH30	7.1
Soft tissue	SKLMS1	7.2
Soft tissue	SKUT1	7.1
Soft tissue	TE125T	8.5
Soft tissue	TE159T	7.9
Soft tissue	TE441T	8.9
Soft tissue	TE617T	4.4
Stomach	2313287	6.4
Stomach	AGS	6.2
Stomach	AZ521	4.1
Stomach	ECC10	7.8
Stomach	ECC12	6.1
Stomach	FU97	4.1
Stomach	GCIY	4.2
Stomach	GSS	6.7
Stomach	GSU	8
Stomach	HGC27	7.8
Stomach	HS746T	7.8
Stomach	HUG1N	4.6
Stomach	IM95	7.2
Stomach	KATOIII	7.7
Stomach	KE39	7.7
Stomach	LMSU	6.5
Stomach	MKN1	6.5
Stomach	MKN45	7.4
Stomach	MKN74	5.7
Stomach	MKN7	5.9
Stomach	NCCSTCK140	8.7
Stomach	NCIN87	7.4
Stomach	NUGC2	5.9
Stomach	NUGC3	6.2
Stomach	NUGC4	7.4
Stomach	OCUM1	6.7
Stomach	RERFGC1B	4.3
Stomach	SH10TC	4
Stomach	SNU16	7.4
Stomach	SNU1	7.7
Stomach	SNU216	6.9
Stomach	SNU520	8.4
Stomach	SNU5	6.9
Stomach	SNU601	8
Stomach	SNU620	8.6
Stomach	SNU668	7.2
Stomach	SNU719	7.7
Stomach	TGBC11TKB	8.3
Thyroid	8305C	8.9
Thyroid	8505C	7.8
Thyroid	BCPAP	6
Thyroid	BHT101	7.3
Thyroid	CAL62	8.2
Thyroid	CGTHW1	7.5
Thyroid	FTC133	7.9
Thyroid	FTC238	7.7
Thyroid	ML1	7.9
Thyroid	SW579	6.8
Thyroid	TT2609C02	6.9
Thyroid	TT	5.9
Upper aerodigestive tract	BHY	7.4
Upper aerodigestive tract	BICR16	7.4
Upper aerodigestive tract	BICR18	7
Upper aerodigestive tract	BICR22	7.5
Upper aerodigestive tract	BICR31	6.8
Upper aerodigestive tract	BICR56	6.4
Upper aerodigestive tract	BICR6	5.5
Upper aerodigestive tract	CAL27	7.7
Upper aerodigestive tract	CAL33	8.5
Upper aerodigestive tract	DETROIT562	7.3
Upper aerodigestive tract	FADU	7.4
Upper aerodigestive tract	HS840T	6.8
Upper aerodigestive tract	HSC2	7
Upper aerodigestive tract	HSC3	7.1
Upper aerodigestive tract	HSC4	7.2
Upper aerodigestive tract	PECAPJ15	6.9
Upper aerodigestive tract	PECAPJ34CLONEC12	7.9
Upper aerodigestive tract	PECAPJ41CLONED2	6.4
Upper aerodigestive tract	PECAPJ49	7
Upper aerodigestive tract	SCC15	6.7
Upper aerodigestive tract	SCC25	6.9
Upper aerodigestive tract	SCC4	6.7
Upper aerodigestive tract	SCC9	5.9
Upper aerodigestive tract	SNU1076	6.5
Upper aerodigestive tract	SNU1214	7.6
Upper aerodigestive tract	SNU46	7.5
Upper aerodigestive tract	SNU899	7.8
Upper aerodigestive tract	YD10B	5.7
Upper aerodigestive tract	YD38	6.5
Upper aerodigestive tract	YD8	7.6
Urinary tract	5637	6.4
Urinary tract	639V	7.8
Urinary tract	647V	7.6
Urinary tract	BC3C	9.2
Urinary tract	BFTC905	4.6
Urinary tract	CAL29	6.9
Urinary tract	HS172T	8.2
Urinary tract	HT1197	8.3
Urinary tract	HT1376	7.6
Urinary tract	J82	7.1
Urinary tract	JMSU1	6.3
Urinary tract	KMBC2	6.2
Urinary tract	KU1919	8
Urinary tract	RT11284	8.2
Urinary tract	RT112	7.4
Urinary tract	RT4	7.7
Urinary tract	SCABER	6
Urinary tract	SW1710	7.7
Urinary tract	SW780	6.4
Urinary tract	T24	6.9
Urinary tract	TCCSUP	7.3
Urinary tract	UMUC1	8.2
Urinary tract	UMUC3	7
Urinary tract	VMCUB1	7.9

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	63.3
Adrenal gland	83.1
Appendix	49.2
Bone marrow	32.8
Breast	90.6
Cerebral cortex	112.6
Cervix, uterine	72.7
Colon	37.1
Duodenum	22.6
Endometrium	93.3
Epididymis	84.8
Esophagus	47.4
Fallopian tube	99.2
Gallbladder	72.6
Heart muscle	31
Kidney	57.7
Liver	34.9
Lung	70.9
Lymph node	68.4
Ovary	205.8
Pancreas	8.2
Parathyroid gland	353.9
Placenta	77
Prostate	85.6
Rectum	37.9
Salivary gland	27
Seminal vesicle	82.7
Skeletal muscle	39.5
Skin	84.1
Small intestine	33.2
Smooth muscle	63.4
Spleen	76.3
Stomach	33
Testis	116.8
Thyroid gland	105
Tonsil	47.8
Urinary bladder	48.7

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27656868	Loss of Expression	Endometrial Carcinomaetrial undifferentiated carcinoma	Our study shows that almost a third of endometrial undifferentiated carcinomas exhibit loss of SMARCA4 and SMARCA2 and a subset show rhabdoid morphology
26356327	Loss of Expression	Ovarian Small Cell Carcinoma	Among ovarian tumours, the SMARCA4/SMARCA2 dual loss phenotype appears completely specific for SCCOHT.
25948779	Overexpression	HBV-associated Hepatocellular Carcinoma	The DCLK1 overexpression also correlates with increased levels of S100A9, c-Myc, and BRM levels in HCV/HBV-positive patients with cirrhosis and HCC
25808524	Overexpression	Bladder Carcinoma	Here, we report that both BRG1 and BRM are overexpressed in most primary breast cancers independent of the tumor's receptor status.
25496315	Mutation; Loss of Expression	Malignant rhabdoid tumor	Complete loss of SMARCB1, SMARCA2 and PBRM1 expression and corresponding mutations in the same genes were observed in all cases. The mutations included seven missense, three same-sense, four frameshift and two truncating mutations.
25200863	Loss of Expression	Rhabdoid Tumor	The concurrent loss of BRM, PBRM1, and INI1expression was detected in 2 cases with pure rhabdoid tumor features.
24913006	Loss of Expression	Rhabdoid tumor	We show that BRM is an epigenetically silenced gene in 10/11 Rhabdoid cell lines and in 70% of Rhabdoid tumors.
24471421	Loss of Expression	Renal Cell Carcinoma	We have shown that loss of BRM expression is a common feature among poorly differentiated tumours in clear cell RCCs.
24336158	Loss of Expression	Ovarian Clear Cell Carcinoma	Loss of ARID1A expression was present in 35 cases (52%) and loss of SMARCA2 expression occurred in 1 case.
23359823	Polymorphism; Overexpression	Hepatocellular Carcinoma	Quantitative PCR analyses demonstrated that the genotypes of BRM-1321 and the corresponding haplotypes were significantly correlated with BRM expression in vivo. Compared with ins/ins genotype, subjects carrying ins/del and del/del genotype had 2.30 and 4.99 fold higher BRM expression in HCC tissue samples, respectively. Our findings suggest that BRM promoter polymorphism (BRM-1321) could regulate BRM expression and may serve as a potential marker for genetic susceptibility to HCC.
23349796	Overexpression	Melanoma	Immunohistochemistry showed high expression of both BRM and BRG1 in primary melanomas.
23163725	Loss of Expression	Lung Adenocarcinoma	Here, we present evidence that loss of BRG1 and BRM is involved in the progression of lung adenocarcinomas.
23088494	Underexpression (copy number loss)	Hepatocellular Carcinoma	Copy number losses of BRG1 and BRM genes were observed in 14 (26%) and 7 (13%) of 54 primary HCC tumours respectively. Expression of BRM mRNA, but not BRG1 mRNA, was significantly reduced in primary HCC tumours, compared to non-tumour tissue counterparts.
21564052	Underexpression	Squamous Cell Carcinoma	We found reduced levels of mRNA coding for BRM but not BRG1 in SCC.
21478907	Polymorphism; Loss of Expression	Lung Carcinoma	We found an increased risk of lung cancer when both BRM homozygous promoter insertion variants were present: adjusted odds ratio of 2.19 (95% confidence interval, 1.40-3.43). Thus, we here demonstrate a strong functional association between these polymorphisms and loss of BRM expression.
19074882	Underexpression	Prostate Carcinoma	Third, investigation of human specimens revealed that Brm mRNA and protein levels are attenuated in prostate cancer.
18006815	Loss of Expression	Gastric Carcinoma	We observed frequent loss of Brm expression but not of BRG1 in human gastric cancer cell lines.
17075831	altered expression	Prostate Carcinoma	Microarray data showed an aberrant expression of BRG1 and BRM but not SNF5/INI1 genes in different stages of the disease course
16247481	Loss of Expression	Non-Small Cell Lung Carcinoma	Patients with Brm/BRG1-deficient lung carcinoma have been reported to carry poor prognosis; derepression of NRSF-regulated genes including these neuron-specific genes could contribute to enhance tumorigenicity and also would provide selective markers for Brm/BRG1-deficient tumors.
15887247	Loss of Expression; Underexpression	adenocarcinoma	BRG1 and/or BRM protein is absent or disrupted in approximately 17% of all human adenocarcinomas.
12566296	Loss of Expression	Non-Small Cell Lung Carcinoma	In addition, Western blot data have shown that the SWI/SNF ATPase subunits cell, BRG1 and BRM (BRG1/BRM), are lost in approximately 30% of human non-small lung cancer cell lines.
11147808	Loss of Expression	Pancreatic Carcinoma	In this study, we identified the first cell line negative for the BAF57 protein as well as a pancreatic carcinoma cell line negative for both the BRG-1 and hBRM proteins.
28602977	Overexpression	Pancreatic Carcinoma	High BRM expression was correlated with worse survival of pancreatic cancer patients.
28038711	Loss of Expression	Non-Small Cell Lung Carcinoma	In conclusion, SMARCA4 and SMARCA2 deficiency is observed in 5.1% and 4.8% of NSCLC, respectively.
27656868	Loss of Expression	Endometrial Carcinoma	Our study demonstrated that almost one-third of endometrial undifferentiated carcinomas show loss of SMARCA4 and SMARCA2 expression, and that a subset show rhabdoid morphology.

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.449	1.99e-21	43.1	35.9	21	Loss
BRCA	Breast invasive carcinoma	1075	0.425	2.7e-48	30.4	52.7	16.8	Neutral
CESC	Cervical and endocervical cancers	292	0.565	4.45e-26	20.2	58.9	20.9	Neutral
COAD	Colon adenocarcinoma	449	0.348	2.95e-14	12.5	68.8	18.7	Neutral
ESCA	Esophageal carcinoma	183	0.502	4.53e-13	59.6	27.9	12.6	Loss
GBM	Glioblastoma multiforme	147	0.523	1.06e-11	39.5	49.7	10.9	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.531	8.39e-39	41.6	35.8	22.6	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.464	2.15e-29	28.2	68.6	3.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.347	1.41e-09	12.2	86.8	1	Neutral
LAML	Acute Myeloid Leukemia	166	0.083	0.29	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.487	6.25e-32	29	68	2.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.491	1.81e-23	32.4	60.4	7.1	Neutral
LUAD	Lung adenocarcinoma	512	0.357	7.65e-17	53.1	34.4	12.5	Loss
LUSC	Lung squamous cell carcinoma	498	0.538	1.18e-38	66.1	17.5	16.5	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.411	1.19e-13	44	29.3	26.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.535	1.6e-14	44.6	50.3	5.1	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.39	2.81e-07	9.9	87	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.407	4.8e-21	9.2	85.1	5.7	Neutral
READ	Rectum adenocarcinoma	164	0.319	3.11e-05	17.7	56.1	26.2	Neutral
SARC	Sarcoma	255	0.489	9.61e-17	38.4	42.7	18.8	Loss
SKCM	Skin Cutaneous Melanoma	367	0.394	4.42e-15	66.5	27	6.5	Loss
STAD	Stomach adenocarcinoma	413	0.285	3.9e-09	41.4	43.8	14.8	Loss
TGCT	Testicular Germ Cell Tumors	150	0.129	0.116	46	42.7	11.3	Loss
THCA	Thyroid carcinoma	497	0.265	2.11e-09	4	95	1	Neutral
THYM	Thymoma	119	0.264	0.00372	5	85.7	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.253	2.67e-09	14.5	75	10.4	Neutral

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.307	1.19e-10	17	408	-0.002	1.31e-10	NS/NA
BRCA	Breast invasive carcinoma	-0.295	8.18e-19	83	785	0.004	2.35e-10	NS/NA
CESC	Cervical and endocervical cancers	-0.321	9.67e-09	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.318	8.7e-09	19	297	0.003	0.00938	NS/NA
ESCA	Esophageal carcinoma	-0.344	1.08e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.461	0.000132	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.453	0	20	522	0.003	2.97e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.348	4.29e-11	24	319	0.014	1.07e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.359	2.26e-10	23	275	0.007	8.12e-11	NS/NA
LAML	Acute Myeloid Leukemia	-0.219	0.00419	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.292	8.53e-12	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.385	1.8e-16	41	373	0.013	4.44e-11	NS/NA
LUAD	Lung adenocarcinoma	-0.146	0.00143	21	456	-0.003	0.602	NS/NA
LUSC	Lung squamous cell carcinoma	-0.313	6.28e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.517	0.162	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.326	7.5e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.145	0.0477	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.285	2.31e-11	35	498	0.005	0.00542	NS/NA
READ	Rectum adenocarcinoma	-0.342	0.00049	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.445	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.362	5.17e-16	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.479	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.679	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.158	0.000183	50	509	0.001	0.00115	NS/NA
THYM	Thymoma	-0.27	0.00267	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.155	0.000827	34	431	-0.001	0.336	NS/NA

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	3	High
Breast	3	High
Bronchus	2	Medium
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	3	High
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.658	NS	24476821
BRCA	Breast invasive carcinoma	521	7.51e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.918	NS	22810696
GBM	Glioblastoma multiforme	157	0.178	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.5e-09	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.727	NS	26536169
LGG	Brain Lower Grade Glioma	513	5.03e-10	Significant	26824661
LUAD	Lung adenocarcinoma	230	2.78e-07	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	8.04e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.23e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.369	NS	26544944
READ	Rectum adenocarcinoma	67	0.706	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.417	NS	26091043
STAD	Stomach adenocarcinoma	277	3.94e-14	Significant	25079317
THCA	Thyroid carcinoma	391	3.12e-19	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	9.79e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.045	0.826	NS
BRCA	Breast invasive carcinoma	1079	0.748	0.216	NS
CESC	Cervical and endocervical cancers	291	0.677	0.25	NS
COAD	Colon adenocarcinoma	439	1.087	0.753	NS
ESCA	Esophageal carcinoma	184	0.418	0.0125	Longer
GBM	Glioblastoma multiforme	158	0.89	0.636	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.688	0.0701	NS
KIRC	Kidney renal clear cell carcinoma	531	0.286	3.8e-08	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.379	0.0373	Longer
LAML	Acute Myeloid Leukemia	149	0.965	0.901	NS
LGG	Brain Lower Grade Glioma	511	0.706	0.158	NS
LIHC	Liver hepatocellular carcinoma	365	0.567	0.0234	Longer
LUAD	Lung adenocarcinoma	502	0.831	0.406	NS
LUSC	Lung squamous cell carcinoma	494	0.92	0.666	NS
OV	Ovarian serous cystadenocarcinoma	303	0.847	0.426	NS
PAAD	Pancreatic adenocarcinoma	177	0.528	0.0294	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.17	NS
PRAD	Prostate adenocarcinoma	497	0	0.221	NS
READ	Rectum adenocarcinoma	159	0.694	0.479	NS
SARC	Sarcoma	259	1.164	0.605	NS
SKCM	Skin Cutaneous Melanoma	459	0.692	0.0522	NS
STAD	Stomach adenocarcinoma	388	0.816	0.344	NS
TGCT	Testicular Germ Cell Tumors	134	846372263.201	0.243	NS
THCA	Thyroid carcinoma	500	2.614	0.16	NS
THYM	Thymoma	119	6.569	0.0575	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.606	0.0838	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.129	0.00906	Higher
BRCA	Breast invasive carcinoma	1071	-0.082	0.00756	Lower
CESC	Cervical and endocervical cancers	167	0.033	0.673	NS
COAD	Colon adenocarcinoma	445	0.024	0.616	NS
ESCA	Esophageal carcinoma	162	-0.049	0.533	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.077	0.102	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.238	2.84e-08	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.137	0.0275	Lower
LIHC	Liver hepatocellular carcinoma	347	-0.025	0.639	NS
LUAD	Lung adenocarcinoma	507	-0.1	0.0246	Lower
LUSC	Lung squamous cell carcinoma	497	-0.046	0.309	NS
OV	Ovarian serous cystadenocarcinoma	302	0.094	0.102	NS
PAAD	Pancreatic adenocarcinoma	176	-0.188	0.0124	Lower
READ	Rectum adenocarcinoma	156	0.074	0.356	NS
SKCM	Skin Cutaneous Melanoma	410	-0.022	0.658	NS
STAD	Stomach adenocarcinoma	392	0.004	0.931	NS
TGCT	Testicular Germ Cell Tumors	81	-0.402	0.000197	Lower
THCA	Thyroid carcinoma	499	-0.08	0.0729	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.126	0.00458	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.034	0.582	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.167	0.000174	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.209	1.35e-06	Lower
LGG	Brain Lower Grade Glioma	514	-0.249	1.07e-08	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.282	4.19e-08	Lower
OV	Ovarian serous cystadenocarcinoma	296	-0.073	0.209	NS
PAAD	Pancreatic adenocarcinoma	176	-0.198	0.00839	Lower
STAD	Stomach adenocarcinoma	406	0.115	0.02	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.105	0.0152	Lower

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMARCA2.

Summary
Symbol	SMARCA2
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Aliases	hSNF2a; hBRM; Sth1p; SNF2LA; BRM; SNF2L2; NCBRS; ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated fa ......
Location	9p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25948779	HBV-associated Hepatocellular Carcinoma	partner	DCLK1	Positive correlation	The DCLK1 overexpression also correlates with increased levels of S100A9, c-Myc, and BRM levels in HCV/HBV-positive patients with cirrhosis and HCC
19074882	Prostate Carcinoma	downstream	E2F1	regulation	Lastly, gene expression profiling showed that Brm loss alters factors upstream of E2F1; this was confirmed in murine models, wherein Brm loss induced E2F1 deregulation in a tissue-specific manner.
28602977	Pancreatic Carcinoma	downstream	JAK2/STAT3	Positive regulation	We reveal a novel mechanism by which BRM could activate JAK2/STAT3 pathway to promote pancreatic cancer growth and chemoresistance.