CR2Cancer

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF13892 DNA-binding domain
PF09110 HAND
PF00271 Helicase conserved C-terminal domain
PF09111 SLIDE
PF00176 SNF2 family N-terminal domain

Function

Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	10880450

> Gene Ontology [ TOP ]
Biological Process	GO:0000183 chromatin silencing at rDNA GO:0006302 double-strand break repair GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006352 DNA-templated transcription, initiation GO:0016458 gene silencing GO:0016584 nucleosome positioning GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0034080 CENP-A containing nucleosome assembly GO:0034508 centromere complex assembly GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0040029 regulation of gene expression, epigenetic GO:0043044 ATP-dependent chromatin remodeling GO:0043486 histone exchange GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0061641 CENP-A containing chromatin organization GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization
Molecular Function	GO:0003682 chromatin binding GO:0004386 helicase activity GO:0016887 ATPase activity GO:0031491 nucleosome binding GO:0042393 histone binding
Cellular Component	GO:0000793 condensed chromosome GO:0005657 replication fork GO:0005677 chromatin silencing complex GO:0016589 NURF complex GO:0017053 transcriptional repressor complex GO:0031010 ISWI-type complex GO:0031213 RSF complex GO:0043596 nuclear replication fork GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-1640170: Cell Cycle R-HSA-73886: Chromosome Maintenance R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-774815: Nucleosome assembly R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-1640170: Cell Cycle
R-HSA-73886: Chromosome Maintenance
R-HSA-5693606: DNA Double Strand Break Response
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-774815: Nucleosome assembly
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1051616	c.2138A>C	p.N713T	Substitution - Missense	Endometrium
COSM3126258	c.1515C>T	p.F505F	Substitution - coding silent	Cervix
COSM3600571	c.429C>T	p.H143H	Substitution - coding silent	Skin
COSM1495753	c.1365A>G	p.K455K	Substitution - coding silent	Kidney
COSM5060144	c.2131G>C	p.V711L	Substitution - Missense	Stomach
COSM5550675	c.2605G>A	p.A869T	Substitution - Missense	Prostate
COSM3714711	c.347C>G	p.S116*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM4790699	c.2435C>T	p.A812V	Substitution - Missense	Liver
COSM390632	c.1666A>G	p.M556V	Substitution - Missense	Lung
COSM5479995	c.518C>G	p.S173W	Substitution - Missense	Large_intestine
COSM3600572	c.977A>G	p.E326G	Substitution - Missense	Skin
COSM3660907	c.2383A>G	p.T795A	Substitution - Missense	Liver
COSM1186667	c.1502G>A	p.R501Q	Substitution - Missense	Lung
COSM3428201	c.3021G>T	p.L1007F	Substitution - Missense	Large_intestine
COSM732499	c.2736A>G	p.Q912Q	Substitution - coding silent	Lung
COSM3392716	c.431G>A	p.R144H	Substitution - Missense	Pancreas
COSM1471738	c.854C>T	p.T285I	Substitution - Missense	Prostate
COSM5643170	c.77G>A	p.S26N	Substitution - Missense	Oesophagus
COSM277380	c.377G>A	p.R126Q	Substitution - Missense	Large_intestine
COSM1165422	c.263G>A	p.R88Q	Substitution - Missense	Large_intestine
COSM4823275	c.2944C>T	p.Q982*	Substitution - Nonsense	Cervix
COSM3660908	c.3062C>T	p.A1021V	Substitution - Missense	Liver
COSM5400538	c.469G>A	p.E157K	Substitution - Missense	Skin
COSM1051630	c.2871T>C	p.C957C	Substitution - coding silent	Endometrium
COSM5400539	c.621+2T>C	p.?	Unknown	Skin
COSM1671343	c.893A>C	p.K298T	Substitution - Missense	Large_intestine
COSM3126247	c.371G>A	p.R124H	Substitution - Missense	Large_intestine
COSM4122508	c.3086A>T	p.K1029M	Substitution - Missense	Stomach
COSM3770401	c.2943_2947delTCAGT	p.F983fs*2	Deletion - Frameshift	Soft_tissue
COSM5500998	c.2731A>G	p.I911V	Substitution - Missense	Biliary_tract
COSM4996398	c.1553A>T	p.Y518F	Substitution - Missense	Upper_aerodigestive_tract
COSM5466058	c.2591A>C	p.D864A	Substitution - Missense	Large_intestine
COSM3428200	c.399G>T	p.Q133H	Substitution - Missense	Large_intestine
COSM4122505	c.2694G>A	p.E898E	Substitution - coding silent	Stomach
COSM1226769	c.430C>T	p.R144C	Substitution - Missense	Large_intestine
COSM1051632	c.2882A>C	p.K961T	Substitution - Missense	Endometrium
COSM5502899	c.1495+7G>A	p.?	Unknown	Biliary_tract
COSM1427322	c.2390G>T	p.G797V	Substitution - Missense	Large_intestine
COSM4427474	c.2007C>G	p.I669M	Substitution - Missense	Oesophagus
COSM3825264	c.588G>A	p.E196E	Substitution - coding silent	Breast
COSM5060143	c.831G>A	p.P277P	Substitution - coding silent	Stomach
COSM1051601	c.425G>A	p.R142Q	Substitution - Missense	Endometrium
COSM4915588	c.2458A>G	p.I820V	Substitution - Missense	Liver
COSM3946021	c.594C>A	p.G198G	Substitution - coding silent	Lung
COSM3126247	c.371G>A	p.R124H	Substitution - Missense	Large_intestine
COSM3600574	c.1657T>A	p.F553I	Substitution - Missense	Skin
COSM1051638	c.3076C>T	p.R1026*	Substitution - Nonsense	Endometrium
COSM4798636	c.1315G>A	p.G439S	Substitution - Missense	Liver
COSM5031854	c.295A>T	p.T99S	Substitution - Missense	Pancreas
COSM3126259	c.1679G>A	p.R560H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5563605	c.1023G>C	p.Q341H	Substitution - Missense	Prostate
COSM4847180	c.1195G>C	p.D399H	Substitution - Missense	Cervix
COSM1051628	c.2677G>A	p.E893K	Substitution - Missense	Endometrium
COSM3781759	c.27A>C	p.P9P	Substitution - coding silent	Pancreas
COSM3126254	c.1286T>C	p.M429T	Substitution - Missense	Large_intestine
COSM4618396	c.2285C>T	p.A762V	Substitution - Missense	Large_intestine
COSM5737104	c.1379C>A	p.P460Q	Substitution - Missense	Small_intestine
COSM3825266	c.2052+2T>G	p.?	Unknown	Breast
COSM5671324	c.584A>G	p.Y195C	Substitution - Missense	Soft_tissue
COSM420181	c.2899G>C	p.E967Q	Substitution - Missense	Urinary_tract
COSM5436232	c.39C>A	p.P13P	Substitution - coding silent	Oesophagus
COSM5481862	c.1984T>C	p.F662L	Substitution - Missense	Large_intestine
COSM4122504	c.2446G>A	p.E816K	Substitution - Missense	Stomach
COSM392512	c.2985_2985+1insGT	p.E996fs*10	Unknown	Lung
COSM1226769	c.430C>T	p.R144C	Substitution - Missense	Large_intestine
COSM5000814	c.873T>G	p.I291M	Substitution - Missense	Pancreas
COSM1427323	c.2858G>A	p.R953H	Substitution - Missense	Large_intestine
COSM13922	c.457G>A	p.E153K	Substitution - Missense	Skin
COSM3946022	c.1496G>T	p.G499V	Substitution - Missense	Lung
COSM4728300	c.2006T>C	p.I669T	Substitution - Missense	Large_intestine
COSM1186666	c.368G>T	p.G123V	Substitution - Missense	Lung
COSM3946023	c.2629C>G	p.P877A	Substitution - Missense	Lung
COSM3126262	c.1904G>A	p.G635E	Substitution - Missense	Large_intestine
COSM1051634	c.2953T>C	p.F985L	Substitution - Missense	Endometrium
COSM4770283	c.599A>G	p.N200S	Substitution - Missense	Adrenal_gland
COSM5419899	c.1608T>G	p.D536E	Substitution - Missense	Pancreas
COSM4511903	c.884C>A	p.S295Y	Substitution - Missense	Skin
COSM1427319	c.520+2T>C	p.?	Unknown	Large_intestine
COSM3714711	c.347C>G	p.S116*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3373404	c.2352A>G	p.L784L	Substitution - coding silent	Thyroid
COSM170542	c.500G>A	p.R167Q	Substitution - Missense	Endometrium
COSM1226771	c.1279A>G	p.I427V	Substitution - Missense	Large_intestine
COSM5455270	c.2434G>A	p.A812T	Substitution - Missense	Large_intestine
COSM480909	c.2213G>A	p.R738K	Substitution - Missense	Kidney
COSM5995746	c.2088C>T	p.G696G	Substitution - coding silent	Prostate
COSM13922	c.457G>A	p.E153K	Substitution - Missense	Skin
COSM4798636	c.1315G>A	p.G439S	Substitution - Missense	Liver
COSM3760414	c.406C>T	p.L136L	Substitution - coding silent	Large_intestine
COSM5756435	c.2831G>A	p.G944E	Substitution - Missense	Large_intestine
COSM1266241	c.3057G>C	p.E1019D	Substitution - Missense	Oesophagus
COSM4779594	c.1810G>T	p.V604L	Substitution - Missense	Liver
COSM5516313	c.2257C>T	p.R753C	Substitution - Missense	Biliary_tract
COSM4465348	c.1379C>T	p.P460L	Substitution - Missense	Skin
COSM3825268	c.2105A>C	p.N702T	Substitution - Missense	Breast
COSM277380	c.377G>A	p.R126Q	Substitution - Missense	Large_intestine
COSM447434	c.2707C>T	p.Q903*	Substitution - Nonsense	Breast
COSM4728301	c.2393A>G	p.Y798C	Substitution - Missense	Large_intestine
COSM3126271	c.2421T>G	p.P807P	Substitution - coding silent	Large_intestine
COSM5709087	c.1127G>C	p.G376A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5930238	c.770C>A	p.S257Y	Substitution - Missense	Skin
COSM285198	c.3144G>T	p.K1048N	Substitution - Missense	Large_intestine
COSM3825265	c.1378C>T	p.P460S	Substitution - Missense	Breast
COSM1427321	c.1678C>T	p.R560C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4122506	c.2743A>G	p.I915V	Substitution - Missense	Stomach
COSM4465870	c.1403C>T	p.P468L	Substitution - Missense	Skin
COSM4122507	c.3034A>C	p.N1012H	Substitution - Missense	Stomach
COSM3660907	c.2383A>G	p.T795A	Substitution - Missense	Liver
COSM1427324	c.3118G>A	p.A1040T	Substitution - Missense	Central_nervous_system
COSM1051636	c.3041A>G	p.E1014G	Substitution - Missense	Endometrium
COSM3600576	c.2692G>A	p.E898K	Substitution - Missense	Skin
COSM3660906	c.1595A>G	p.Q532R	Substitution - Missense	Liver
COSM5026224	c.1719A>G	p.V573V	Substitution - coding silent	Breast
COSM1427320	c.1641A>C	p.E547D	Substitution - Missense	Large_intestine
COSM1226770	c.2921G>A	p.R974Q	Substitution - Missense	Large_intestine
COSM1051620	c.2503G>T	p.E835*	Substitution - Nonsense	Endometrium
COSM3660908	c.3062C>T	p.A1021V	Substitution - Missense	Liver
COSM1051622	c.2546A>C	p.D849A	Substitution - Missense	Endometrium
COSM3660906	c.1595A>G	p.Q532R	Substitution - Missense	Liver
COSM1427321	c.1678C>T	p.R560C	Substitution - Missense	Large_intestine
COSM222041	c.496A>G	p.T166A	Substitution - Missense	Skin
COSM4413010	c.1125T>A	p.L375L	Substitution - coding silent	Oesophagus
COSM4790699	c.2435C>T	p.A812V	Substitution - Missense	Liver
COSM1051626	c.2594T>C	p.I865T	Substitution - Missense	Endometrium
COSM3357780	c.544G>A	p.D182N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1186667	c.1502G>A	p.R501Q	Substitution - Missense	Large_intestine
COSM3373405	c.2467G>C	p.A823P	Substitution - Missense	Thyroid
COSM3825267	c.2061G>A	p.E687E	Substitution - coding silent	Breast
COSM1566991	c.1869G>T	p.M623I	Substitution - Missense	Large_intestine
COSM3126284	c.2988G>T	p.E996D	Substitution - Missense	Large_intestine
COSM5995590	c.2565A>G	p.K855K	Substitution - coding silent	Prostate
COSM1427324	c.3118G>A	p.A1040T	Substitution - Missense	Large_intestine
COSM3409071	c.1894A>T	p.I632F	Substitution - Missense	Central_nervous_system
COSM5918521	c.621+5G>T	p.?	Unknown	Skin
COSM1671343	c.893A>C	p.K298T	Substitution - Missense	Large_intestine
COSM1051604	c.894A>C	p.K298N	Substitution - Missense	Endometrium
COSM3993484	c.424C>T	p.R142*	Substitution - Nonsense	Kidney
COSM4414653	c.1415A>C	p.Y472S	Substitution - Missense	Kidney
COSM3126284	c.2988G>T	p.E996D	Substitution - Missense	Large_intestine
COSM1051640	c.3131G>A	p.R1044Q	Substitution - Missense	Endometrium
COSM447433	c.1759C>A	p.L587I	Substitution - Missense	Breast
COSM1051618	c.2467G>A	p.A823T	Substitution - Missense	Endometrium
COSM1753556	c.2565A>T	p.K855N	Substitution - Missense	Urinary_tract
COSM1051610	c.1756G>A	p.D586N	Substitution - Missense	Endometrium
COSM4945215	c.1730A>G	p.Y577C	Substitution - Missense	Testis
COSM1051624	c.2572G>A	p.E858K	Substitution - Missense	Endometrium
COSM1051612	c.2022C>T	p.I674I	Substitution - coding silent	Endometrium
COSM3600575	c.2393A>C	p.Y798S	Substitution - Missense	Skin
COSM1633471	c.1506A>G	p.V502V	Substitution - coding silent	Liver
COSM1051599	c.205A>C	p.K69Q	Substitution - Missense	Endometrium
COSM1427319	c.520+2T>C	p.?	Unknown	Large_intestine
COSM3126275	c.2607A>C	p.A869A	Substitution - coding silent	Prostate
COSM1051601	c.425G>A	p.R142Q	Substitution - Missense	Endometrium
COSM1051608	c.1607A>C	p.D536A	Substitution - Missense	Endometrium
COSM732500	c.1276C>A	p.R426R	Substitution - coding silent	Lung
COSM4443477	c.2230G>A	p.V744I	Substitution - Missense	Large_intestine
COSM4391736	c.2348A>T	p.E783V	Substitution - Missense	Prostate
COSM4885274	c.3029G>C	p.R1010T	Substitution - Missense	Upper_aerodigestive_tract
COSM258059	c.799A>C	p.R267R	Substitution - coding silent	Large_intestine
COSM4883987	c.418G>T	p.D140Y	Substitution - Missense	Upper_aerodigestive_tract
COSM1195778	c.2258G>A	p.R753H	Substitution - Missense	Lung
COSM373166	c.1806C>G	p.V602V	Substitution - coding silent	Lung
COSM1051614	c.2131G>A	p.V711I	Substitution - Missense	Endometrium
COSM4392697	c.2969A>G	p.K990R	Substitution - Missense	Prostate
COSM480910	c.2992C>A	p.Q998K	Substitution - Missense	Kidney
COSM1753556	c.2565A>T	p.K855N	Substitution - Missense	Urinary_tract
COSM126319	c.3128G>T	p.G1043V	Substitution - Missense	Upper_aerodigestive_tract
COSM5912139	c.2398-6T>A	p.?	Unknown	Skin
COSM1051606	c.949A>C	p.K317Q	Substitution - Missense	Endometrium
COSM3600573	c.1477C>T	p.P493S	Substitution - Missense	Skin
COSM4882832	c.1766C>G	p.A589G	Substitution - Missense	Upper_aerodigestive_tract
COSM4728299	c.1137A>G	p.K379K	Substitution - coding silent	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for SMARCA5.

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O60264	66	S	Phosphoserine	-	No	None detected
O60264	113	T	Phosphothreonine	-	No	None detected
O60264	116	S	Phosphoserine	-	No	None detected
O60264	137	S	Phosphoserine	-	No	None detected
O60264	171	S	Phosphoserine	-	No	None detected
O60264	440	K	N6-acetyllysine	-	No	None detected
O60264	755	S	Phosphoserine	-	No	None detected
O60264	825	S	Phosphoserine	-	No	None detected

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.683	6.462	-0.245	0.122	NS
BRCA	Breast invasive carcinoma	112	1100	6.876	7.029	0.127	0.0272	NS
CESC	Cervical and endocervical cancers	3	306	6.238	6.468	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.387	6.606	0.118	0.224	NS
ESCA	Esophageal carcinoma	11	185	6.631	6.793	0.169	0.393	NS
GBM	Glioblastoma multiforme	5	166	6.38	6.781	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.241	6.466	0.249	0.00434	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.718	6.461	-0.34	6.13e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.419	6.161	-0.314	0.00751	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.11	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.044	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.228	4.959	-0.261	0.0131	NS
LUAD	Lung adenocarcinoma	59	517	7.133	6.632	-0.537	2.41e-16	NS
LUSC	Lung squamous cell carcinoma	51	501	7.058	6.609	-0.42	5.24e-09	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.962	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.447	6.458	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.873	6.539	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.62	6.397	-0.221	0.00889	NS
READ	Rectum adenocarcinoma	10	167	6.479	6.484	-0.1	0.685	NS
SARC	Sarcoma	2	263	5.827	6.333	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.797	6.634	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.277	6.627	0.324	0.00014	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.22	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.864	6.794	-0.073	0.232	NS
THYM	Thymoma	2	120	6.716	6.566	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.293	6.347	0.008	0.953	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.3
Autonomic ganglia	CHP212	10.4
Autonomic ganglia	IMR32	10.5
Autonomic ganglia	KELLY	10.5
Autonomic ganglia	KPNRTBM1	10
Autonomic ganglia	KPNSI9S	9.7
Autonomic ganglia	KPNYN	10.3
Autonomic ganglia	MHHNB11	9.8
Autonomic ganglia	NB1	10.7
Autonomic ganglia	NH6	9.9
Autonomic ganglia	SHSY5Y	10.7
Autonomic ganglia	SIMA	10.8
Autonomic ganglia	SKNAS	10.3
Autonomic ganglia	SKNBE2	10.5
Autonomic ganglia	SKNDZ	10.6
Autonomic ganglia	SKNFI	10.2
Autonomic ganglia	SKNSH	9.9
Biliary tract	HUCCT1	9.3
Biliary tract	HUH28	8.9
Biliary tract	SNU1079	9.3
Biliary tract	SNU1196	9.2
Biliary tract	SNU245	8.6
Biliary tract	SNU308	9.5
Biliary tract	SNU478	9.2
Bone	143B	10.2
Bone	A673	9.8
Bone	CADOES1	9.9
Bone	CAL78	9.5
Bone	G292CLONEA141B1	10.3
Bone	HOS	10.3
Bone	HS706T	9.2
Bone	HS737T	9.1
Bone	HS819T	9.1
Bone	HS821T	9.4
Bone	HS822T	9
Bone	HS863T	9.4
Bone	HS870T	9.2
Bone	HS888T	9.8
Bone	MG63	9.1
Bone	MHHES1	10
Bone	OUMS27	9
Bone	RDES	9.3
Bone	SJSA1	9.7
Bone	SKES1	9.9
Bone	SKNMC	9.8
Bone	SW1353	9.3
Bone	T173	8.9
Bone	TC71	9.8
Bone	U2OS	9.2
Breast	AU565	9.3
Breast	BT20	9.6
Breast	BT474	9.9
Breast	BT483	10.4
Breast	BT549	9.1
Breast	CAL120	10
Breast	CAL148	10.1
Breast	CAL51	10.6
Breast	CAL851	8.7
Breast	CAMA1	9.4
Breast	DU4475	9.7
Breast	EFM192A	9.5
Breast	EFM19	10.3
Breast	EVSAT	9.6
Breast	HCC1143	8.7
Breast	HCC1187	9.6
Breast	HCC1395	9.3
Breast	HCC1419	10.1
Breast	HCC1428	9.8
Breast	HCC1500	9.2
Breast	HCC1569	9.5
Breast	HCC1599	9.9
Breast	HCC1806	9.4
Breast	HCC1937	10.1
Breast	HCC1954	8.9
Breast	HCC202	9.5
Breast	HCC2157	9.3
Breast	HCC2218	9.3
Breast	HCC38	10.1
Breast	HCC70	9.1
Breast	HDQP1	9.6
Breast	HMC18	9.9
Breast	HS274T	9.7
Breast	HS281T	9.5
Breast	HS343T	9.5
Breast	HS578T	8.8
Breast	HS606T	9.7
Breast	HS739T	9.3
Breast	HS742T	8.7
Breast	JIMT1	9.2
Breast	KPL1	9.9
Breast	MCF7	9.6
Breast	MDAMB134VI	9.9
Breast	MDAMB157	9.8
Breast	MDAMB175VII	9.1
Breast	MDAMB231	9.1
Breast	MDAMB361	9.6
Breast	MDAMB415	8.9
Breast	MDAMB436	10
Breast	MDAMB453	9.9
Breast	MDAMB468	9.2
Breast	SKBR3	9.2
Breast	T47D	9
Breast	UACC812	9.1
Breast	UACC893	10.6
Breast	YMB1	9.3
Breast	ZR751	9.4
Breast	ZR7530	9.9
Central nervous system	1321N1	9.7
Central nervous system	42MGBA	9.6
Central nervous system	8MGBA	9.7
Central nervous system	A172	9.1
Central nervous system	AM38	9.8
Central nervous system	BECKER	9.5
Central nervous system	CAS1	9.1
Central nervous system	CCFSTTG1	9.5
Central nervous system	D283MED	9.9
Central nervous system	D341MED	9.8
Central nervous system	DAOY	9.2
Central nervous system	DBTRG05MG	9
Central nervous system	DKMG	10.2
Central nervous system	GAMG	8.9
Central nervous system	GB1	9.5
Central nervous system	GI1	9.3
Central nervous system	GMS10	9.9
Central nervous system	GOS3	9.5
Central nervous system	H4	9.2
Central nervous system	HS683	9.4
Central nervous system	KALS1	9.7
Central nervous system	KG1C	8.7
Central nervous system	KNS42	9
Central nervous system	KNS60	9
Central nervous system	KNS81	9.6
Central nervous system	KS1	9.8
Central nervous system	LN18	9.5
Central nervous system	LN229	9.4
Central nervous system	M059K	8.7
Central nervous system	MOGGCCM	8.7
Central nervous system	MOGGUVW	10.2
Central nervous system	NMCG1	9.2
Central nervous system	ONS76	8.9
Central nervous system	SF126	9.9
Central nervous system	SF295	9.3
Central nervous system	SNB19	10
Central nervous system	SNU1105	9.1
Central nervous system	SNU201	9.5
Central nervous system	SNU466	8.6
Central nervous system	SNU489	9
Central nervous system	SNU626	9.6
Central nervous system	SNU738	9.9
Central nervous system	SW1088	9.4
Central nervous system	SW1783	9.2
Central nervous system	T98G	9.5
Central nervous system	TM31	9.7
Central nervous system	U118MG	9.1
Central nervous system	U138MG	9.5
Central nervous system	U251MG	9.8
Central nervous system	U87MG	8.9
Central nervous system	YH13	9.7
Central nervous system	YKG1	9.9
Endometrium	AN3CA	9.9
Endometrium	COLO684	10.1
Endometrium	EFE184	9.3
Endometrium	EN	9.6
Endometrium	ESS1	9.6
Endometrium	HEC108	9.7
Endometrium	HEC151	10.4
Endometrium	HEC1A	10.6
Endometrium	HEC1B	9.7
Endometrium	HEC251	10.2
Endometrium	HEC265	9.8
Endometrium	HEC50B	10
Endometrium	HEC59	10.6
Endometrium	HEC6	9.6
Endometrium	ISHIKAWAHERAKLIO02ER	10.1
Endometrium	JHUEM1	9.8
Endometrium	JHUEM2	10.4
Endometrium	JHUEM3	10.2
Endometrium	KLE	9.3
Endometrium	MFE280	9.8
Endometrium	MFE296	9.4
Endometrium	MFE319	9.6
Endometrium	RL952	9.5
Endometrium	SNGM	9.8
Endometrium	SNU1077	9.8
Endometrium	SNU685	10
Endometrium	TEN	10.4
Haematopoietic and lymphoid	697	11.3
Haematopoietic and lymphoid	A3KAW	10.3
Haematopoietic and lymphoid	A4FUK	10.2
Haematopoietic and lymphoid	ALLSIL	10.9
Haematopoietic and lymphoid	AML193	9.8
Haematopoietic and lymphoid	AMO1	10.8
Haematopoietic and lymphoid	BCP1	10.2
Haematopoietic and lymphoid	BDCM	10.6
Haematopoietic and lymphoid	BL41	11.4
Haematopoietic and lymphoid	BL70	10.7
Haematopoietic and lymphoid	BV173	10.5
Haematopoietic and lymphoid	CA46	10.3
Haematopoietic and lymphoid	CI1	10.4
Haematopoietic and lymphoid	CMK115	10.4
Haematopoietic and lymphoid	CMK86	10.4
Haematopoietic and lymphoid	CMK	10.1
Haematopoietic and lymphoid	CMLT1	10.3
Haematopoietic and lymphoid	COLO775	9.8
Haematopoietic and lymphoid	DAUDI	10.1
Haematopoietic and lymphoid	DB	10.2
Haematopoietic and lymphoid	DEL	10.3
Haematopoietic and lymphoid	DND41	10
Haematopoietic and lymphoid	DOHH2	10.5
Haematopoietic and lymphoid	EB1	10
Haematopoietic and lymphoid	EB2	9.6
Haematopoietic and lymphoid	EHEB	10.7
Haematopoietic and lymphoid	EJM	9.4
Haematopoietic and lymphoid	EM2	10.5
Haematopoietic and lymphoid	EOL1	10.7
Haematopoietic and lymphoid	F36P	10.5
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	10
Haematopoietic and lymphoid	GRANTA519	10.6
Haematopoietic and lymphoid	HDLM2	10.4
Haematopoietic and lymphoid	HDMYZ	9.7
Haematopoietic and lymphoid	HEL9217	10.4
Haematopoietic and lymphoid	HEL	10.2
Haematopoietic and lymphoid	HH	9.6
Haematopoietic and lymphoid	HL60	10.1
Haematopoietic and lymphoid	HPBALL	10.5
Haematopoietic and lymphoid	HS604T	9.3
Haematopoietic and lymphoid	HS611T	10.3
Haematopoietic and lymphoid	HS616T	9.3
Haematopoietic and lymphoid	HS751T	9.8
Haematopoietic and lymphoid	HT	10.9
Haematopoietic and lymphoid	HTK	10
Haematopoietic and lymphoid	HUNS1	10.3
Haematopoietic and lymphoid	HUT102	10.4
Haematopoietic and lymphoid	HUT78	10.1
Haematopoietic and lymphoid	JEKO1	11.3
Haematopoietic and lymphoid	JK1	10.4
Haematopoietic and lymphoid	JM1	10.6
Haematopoietic and lymphoid	JURKAT	10.3
Haematopoietic and lymphoid	JURLMK1	10.4
Haematopoietic and lymphoid	JVM2	10.9
Haematopoietic and lymphoid	JVM3	10.6
Haematopoietic and lymphoid	K562	9.8
Haematopoietic and lymphoid	KARPAS299	9.9
Haematopoietic and lymphoid	KARPAS422	11.1
Haematopoietic and lymphoid	KARPAS620	9.9
Haematopoietic and lymphoid	KASUMI1	10.5
Haematopoietic and lymphoid	KASUMI2	10.8
Haematopoietic and lymphoid	KASUMI6	10.2
Haematopoietic and lymphoid	KCL22	10.8
Haematopoietic and lymphoid	KE37	10.7
Haematopoietic and lymphoid	KE97	10.6
Haematopoietic and lymphoid	KG1	10.6
Haematopoietic and lymphoid	KHM1B	9.4
Haematopoietic and lymphoid	KIJK	10
Haematopoietic and lymphoid	KMH2	10.6
Haematopoietic and lymphoid	KMM1	10.3
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	9.4
Haematopoietic and lymphoid	KMS18	11.1
Haematopoietic and lymphoid	KMS20	10.3
Haematopoietic and lymphoid	KMS21BM	10.8
Haematopoietic and lymphoid	KMS26	10.5
Haematopoietic and lymphoid	KMS27	9.9
Haematopoietic and lymphoid	KMS28BM	10
Haematopoietic and lymphoid	KMS34	10.1
Haematopoietic and lymphoid	KO52	9.9
Haematopoietic and lymphoid	KOPN8	10
Haematopoietic and lymphoid	KU812	10.9
Haematopoietic and lymphoid	KYO1	9.1
Haematopoietic and lymphoid	L1236	9.8
Haematopoietic and lymphoid	L363	11.1
Haematopoietic and lymphoid	L428	10.5
Haematopoietic and lymphoid	L540	10.2
Haematopoietic and lymphoid	LAMA84	9.9
Haematopoietic and lymphoid	LOUCY	10.9
Haematopoietic and lymphoid	LP1	10
Haematopoietic and lymphoid	M07E	10.7
Haematopoietic and lymphoid	MC116	10.4
Haematopoietic and lymphoid	ME1	9.2
Haematopoietic and lymphoid	MEC1	11.3
Haematopoietic and lymphoid	MEC2	10.5
Haematopoietic and lymphoid	MEG01	9.6
Haematopoietic and lymphoid	MHHCALL2	11.1
Haematopoietic and lymphoid	MHHCALL3	10.6
Haematopoietic and lymphoid	MHHCALL4	11.1
Haematopoietic and lymphoid	MINO	11
Haematopoietic and lymphoid	MJ	10.7
Haematopoietic and lymphoid	MM1S	9.8
Haematopoietic and lymphoid	MOLM13	9.7
Haematopoietic and lymphoid	MOLM16	10
Haematopoietic and lymphoid	MOLM6	9.9
Haematopoietic and lymphoid	MOLP2	9.5
Haematopoietic and lymphoid	MOLP8	10.8
Haematopoietic and lymphoid	MOLT13	10.9
Haematopoietic and lymphoid	MOLT16	10.4
Haematopoietic and lymphoid	MOLT4	10.7
Haematopoietic and lymphoid	MONOMAC1	9.8
Haematopoietic and lymphoid	MONOMAC6	10.3
Haematopoietic and lymphoid	MOTN1	10.1
Haematopoietic and lymphoid	MUTZ5	10.5
Haematopoietic and lymphoid	MV411	9.9
Haematopoietic and lymphoid	NALM19	10.7
Haematopoietic and lymphoid	NALM1	10.8
Haematopoietic and lymphoid	NALM6	11
Haematopoietic and lymphoid	NAMALWA	10.8
Haematopoietic and lymphoid	NB4	10.2
Haematopoietic and lymphoid	NCIH929	9.3
Haematopoietic and lymphoid	NCO2	10.2
Haematopoietic and lymphoid	NOMO1	10
Haematopoietic and lymphoid	NUDHL1	9.4
Haematopoietic and lymphoid	NUDUL1	11.5
Haematopoietic and lymphoid	OCIAML2	9.7
Haematopoietic and lymphoid	OCIAML3	9.7
Haematopoietic and lymphoid	OCIAML5	9.6
Haematopoietic and lymphoid	OCILY10	10.9
Haematopoietic and lymphoid	OCILY19	10.4
Haematopoietic and lymphoid	OCILY3	11.4
Haematopoietic and lymphoid	OCIM1	10.7
Haematopoietic and lymphoid	OPM2	11.1
Haematopoietic and lymphoid	P12ICHIKAWA	10.6
Haematopoietic and lymphoid	P31FUJ	8.5
Haematopoietic and lymphoid	P3HR1	10.3
Haematopoietic and lymphoid	PCM6	9.7
Haematopoietic and lymphoid	PEER	11.2
Haematopoietic and lymphoid	PF382	10.5
Haematopoietic and lymphoid	PFEIFFER	10.6
Haematopoietic and lymphoid	PL21	10.3
Haematopoietic and lymphoid	RAJI	10.6
Haematopoietic and lymphoid	RCHACV	10.9
Haematopoietic and lymphoid	REC1	10.7
Haematopoietic and lymphoid	REH	11.1
Haematopoietic and lymphoid	RI1	10.1
Haematopoietic and lymphoid	RL	10.4
Haematopoietic and lymphoid	RPMI8226	9.6
Haematopoietic and lymphoid	RPMI8402	10.8
Haematopoietic and lymphoid	RS411	10.4
Haematopoietic and lymphoid	SEM	10.7
Haematopoietic and lymphoid	SET2	10.1
Haematopoietic and lymphoid	SIGM5	10.4
Haematopoietic and lymphoid	SKM1	9.7
Haematopoietic and lymphoid	SKMM2	10.3
Haematopoietic and lymphoid	SR786	9.9
Haematopoietic and lymphoid	ST486	9.8
Haematopoietic and lymphoid	SUDHL10	9.8
Haematopoietic and lymphoid	SUDHL1	10.1
Haematopoietic and lymphoid	SUDHL4	9.7
Haematopoietic and lymphoid	SUDHL5	11
Haematopoietic and lymphoid	SUDHL6	9.9
Haematopoietic and lymphoid	SUDHL8	11.6
Haematopoietic and lymphoid	SUPB15	10.7
Haematopoietic and lymphoid	SUPHD1	9.4
Haematopoietic and lymphoid	SUPM2	10.7
Haematopoietic and lymphoid	SUPT11	10.5
Haematopoietic and lymphoid	SUPT1	9.7
Haematopoietic and lymphoid	TALL1	10.8
Haematopoietic and lymphoid	TF1	10.4
Haematopoietic and lymphoid	THP1	9.7
Haematopoietic and lymphoid	TO175T	9.4
Haematopoietic and lymphoid	TOLEDO	11
Haematopoietic and lymphoid	U266B1	10.1
Haematopoietic and lymphoid	U937	9.5
Haematopoietic and lymphoid	UT7	9.9
Haematopoietic and lymphoid	WSUDLCL2	9.9
Kidney	769P	9.9
Kidney	786O	9.3
Kidney	A498	9.1
Kidney	A704	8.9
Kidney	ACHN	10.1
Kidney	BFTC909	9.4
Kidney	CAKI1	9.6
Kidney	CAKI2	9.6
Kidney	CAL54	10.1
Kidney	KMRC1	9.8
Kidney	KMRC20	9.8
Kidney	KMRC2	9.6
Kidney	KMRC3	9.5
Kidney	OSRC2	9.3
Kidney	RCC10RGB	9
Kidney	SNU1272	9.5
Kidney	SNU349	8.8
Kidney	TUHR10TKB	9.8
Kidney	TUHR14TKB	9.5
Kidney	TUHR4TKB	9.5
Kidney	VMRCRCW	9
Kidney	VMRCRCZ	9.6
Large intestine	C2BBE1	10.1
Large intestine	CCK81	10.3
Large intestine	CL11	10.2
Large intestine	CL14	9.7
Large intestine	CL34	10.1
Large intestine	CL40	9.8
Large intestine	COLO205	9.8
Large intestine	COLO320	10.8
Large intestine	COLO678	9.9
Large intestine	CW2	10
Large intestine	DLD1	10.5
Large intestine	GP2D	10.2
Large intestine	HCC56	9.3
Large intestine	HCT116	10.4
Large intestine	HCT15	10.1
Large intestine	HS675T	9.3
Large intestine	HS698T	9.3
Large intestine	HT115	10
Large intestine	HT29	9.9
Large intestine	HT55	9.9
Large intestine	KM12	10.1
Large intestine	LOVO	10.2
Large intestine	LS1034	9.5
Large intestine	LS123	10.1
Large intestine	LS180	10.1
Large intestine	LS411N	10.4
Large intestine	LS513	10
Large intestine	MDST8	8.6
Large intestine	NCIH508	9
Large intestine	NCIH716	10.3
Large intestine	NCIH747	9.6
Large intestine	OUMS23	9.5
Large intestine	RCM1	9.4
Large intestine	RKO	9.5
Large intestine	SKCO1	9.8
Large intestine	SNU1040	9.7
Large intestine	SNU1197	9.8
Large intestine	SNU175	10.2
Large intestine	SNU283	9.4
Large intestine	SNU407	9.9
Large intestine	SNU503	10
Large intestine	SNU61	9.6
Large intestine	SNU81	10.2
Large intestine	SNUC1	9.1
Large intestine	SNUC2A	10.1
Large intestine	SNUC4	10.3
Large intestine	SNUC5	10.7
Large intestine	SW1116	9.2
Large intestine	SW1417	9.5
Large intestine	SW1463	9.2
Large intestine	SW403	9.8
Large intestine	SW480	9.3
Large intestine	SW48	10.4
Large intestine	SW620	9.9
Large intestine	SW837	10.6
Large intestine	SW948	9.9
Large intestine	T84	9.2
Liver	ALEXANDERCELLS	10.1
Liver	C3A	9.4
Liver	HEP3B217	10.2
Liver	HEPG2	9.3
Liver	HLE	10.4
Liver	HLF	10.4
Liver	HUH1	8.8
Liver	HUH6	10.2
Liver	HUH7	10.4
Liver	JHH1	9.4
Liver	JHH2	9.1
Liver	JHH4	9.5
Liver	JHH5	9
Liver	JHH6	9.1
Liver	JHH7	10.1
Liver	LI7	9.6
Liver	PLCPRF5	9.5
Liver	SKHEP1	9.5
Liver	SNU182	9.7
Liver	SNU387	8.9
Liver	SNU398	9.7
Liver	SNU423	8.7
Liver	SNU449	9.2
Liver	SNU475	9.5
Liver	SNU761	9.6
Liver	SNU878	9.3
Liver	SNU886	9.9
Lung	A549	9.7
Lung	ABC1	10.3
Lung	BEN	9.6
Lung	CAL12T	9.4
Lung	CALU1	9.1
Lung	CALU3	9.6
Lung	CALU6	9.5
Lung	CHAGOK1	10.8
Lung	COLO668	10.3
Lung	COLO699	9.4
Lung	CORL105	9.9
Lung	CORL23	9.2
Lung	CORL24	9
Lung	CORL279	10.2
Lung	CORL311	9.6
Lung	CORL47	9.9
Lung	CORL51	9.3
Lung	CORL88	10.8
Lung	CORL95	9.9
Lung	CPCN	10.2
Lung	DMS114	9.9
Lung	DMS153	10.6
Lung	DMS273	9.8
Lung	DMS454	9.5
Lung	DMS53	9.3
Lung	DMS79	10
Lung	DV90	9.9
Lung	EBC1	10.2
Lung	EPLC272H	9
Lung	HARA	10
Lung	HCC1171	10.3
Lung	HCC1195	8.9
Lung	HCC15	8.6
Lung	HCC2279	10.1
Lung	HCC2935	9.4
Lung	HCC33	10.7
Lung	HCC366	10.1
Lung	HCC4006	10
Lung	HCC44	9.8
Lung	HCC78	9.3
Lung	HCC827	10.2
Lung	HCC95	9.8
Lung	HLC1	9.4
Lung	HLFA	9.5
Lung	HS229T	9.6
Lung	HS618T	9.2
Lung	IALM	9.2
Lung	KNS62	9.2
Lung	LC1F	9.7
Lung	LC1SQSF	9.5
Lung	LCLC103H	9.5
Lung	LCLC97TM1	10.3
Lung	LK2	9.8
Lung	LOUNH91	8.3
Lung	LU65	9.5
Lung	LU99	9.6
Lung	LUDLU1	9
Lung	LXF289	10.1
Lung	MORCPR	9.3
Lung	NCIH1048	10.4
Lung	NCIH1092	10.9
Lung	NCIH1105	10.2
Lung	NCIH1155	10.5
Lung	NCIH1184	10.5
Lung	NCIH1299	9
Lung	NCIH1339	10.2
Lung	NCIH1341	9.5
Lung	NCIH1355	9.8
Lung	NCIH1373	9.4
Lung	NCIH1385	10.2
Lung	NCIH1395	9
Lung	NCIH1435	9.5
Lung	NCIH1436	10.3
Lung	NCIH1437	9
Lung	NCIH146	9.9
Lung	NCIH1563	9.6
Lung	NCIH1568	9.6
Lung	NCIH1573	9.5
Lung	NCIH1581	10.7
Lung	NCIH1618	10.8
Lung	NCIH1623	9.5
Lung	NCIH1648	9.6
Lung	NCIH1650	10
Lung	NCIH1651	9.8
Lung	NCIH1666	9.1
Lung	NCIH1693	9.2
Lung	NCIH1694	10.1
Lung	NCIH1703	9.9
Lung	NCIH1734	9.7
Lung	NCIH1755	9.6
Lung	NCIH1781	10.1
Lung	NCIH1792	9.7
Lung	NCIH1793	9.6
Lung	NCIH1836	10.1
Lung	NCIH1838	10.8
Lung	NCIH1869	9.7
Lung	NCIH1876	10.2
Lung	NCIH1915	9.9
Lung	NCIH1930	10.5
Lung	NCIH1944	9.7
Lung	NCIH1963	10.6
Lung	NCIH196	9.1
Lung	NCIH1975	9.4
Lung	NCIH2009	10.4
Lung	NCIH2023	10
Lung	NCIH2029	9.2
Lung	NCIH2030	8.9
Lung	NCIH2066	10.6
Lung	NCIH2081	10.3
Lung	NCIH2085	9.2
Lung	NCIH2087	8.4
Lung	NCIH209	10.3
Lung	NCIH2106	10.2
Lung	NCIH2110	10.1
Lung	NCIH211	9.6
Lung	NCIH2122	9.3
Lung	NCIH2126	9.6
Lung	NCIH2141	10.2
Lung	NCIH2170	10.1
Lung	NCIH2171	9.4
Lung	NCIH2172	10
Lung	NCIH2196	8.6
Lung	NCIH2227	9.8
Lung	NCIH2228	9.2
Lung	NCIH226	9.4
Lung	NCIH2286	10.4
Lung	NCIH2291	9.4
Lung	NCIH2342	8.9
Lung	NCIH2347	9.2
Lung	NCIH23	9.2
Lung	NCIH2405	10
Lung	NCIH2444	8.6
Lung	NCIH292	9.8
Lung	NCIH322	9.8
Lung	NCIH3255	9.4
Lung	NCIH358	10.1
Lung	NCIH441	8.9
Lung	NCIH446	9.7
Lung	NCIH460	9.7
Lung	NCIH510	9.8
Lung	NCIH520	9.9
Lung	NCIH522	9.6
Lung	NCIH524	10.2
Lung	NCIH526	10.1
Lung	NCIH596	9.6
Lung	NCIH647	9.6
Lung	NCIH650	9.8
Lung	NCIH661	9.4
Lung	NCIH69	9.7
Lung	NCIH727	9.7
Lung	NCIH810	10.1
Lung	NCIH82	10.4
Lung	NCIH838	10.3
Lung	NCIH841	10
Lung	NCIH854	9.3
Lung	NCIH889	9.5
Lung	PC14	9.7
Lung	RERFLCAD1	9.5
Lung	RERFLCAD2	9.6
Lung	RERFLCAI	9.5
Lung	RERFLCKJ	9.8
Lung	RERFLCMS	9.6
Lung	RERFLCSQ1	9.2
Lung	SBC5	9.6
Lung	SCLC21H	10.9
Lung	SHP77	9.7
Lung	SKLU1	10
Lung	SKMES1	8.9
Lung	SQ1	9.9
Lung	SW1271	9.2
Lung	SW1573	9.1
Lung	SW900	9
Lung	VMRCLCD	10.1
Lung	VMRCLCP	9.1
Oesophagus	COLO680N	9.5
Oesophagus	ECGI10	9.4
Oesophagus	KYSE140	9.6
Oesophagus	KYSE150	9.1
Oesophagus	KYSE180	9.9
Oesophagus	KYSE270	9
Oesophagus	KYSE30	8.8
Oesophagus	KYSE410	9.8
Oesophagus	KYSE450	8.8
Oesophagus	KYSE510	10
Oesophagus	KYSE520	9.5
Oesophagus	KYSE70	9.3
Oesophagus	OE19	9.9
Oesophagus	OE33	9.8
Oesophagus	TE10	9.4
Oesophagus	TE11	9.5
Oesophagus	TE14	9.6
Oesophagus	TE15	9.6
Oesophagus	TE1	10
Oesophagus	TE4	9.6
Oesophagus	TE5	9.4
Oesophagus	TE6	9.8
Oesophagus	TE8	10.5
Oesophagus	TE9	10
Oesophagus	TT	9.5
Ovary	59M	9.8
Ovary	A2780	10.9
Ovary	CAOV3	9.1
Ovary	CAOV4	9.1
Ovary	COLO704	10.6
Ovary	COV318	9.6
Ovary	COV362	10.1
Ovary	COV434	10.1
Ovary	COV504	9.3
Ovary	COV644	9.7
Ovary	EFO21	9.2
Ovary	EFO27	8.9
Ovary	ES2	9.4
Ovary	FUOV1	10.1
Ovary	HEYA8	9.9
Ovary	HS571T	9
Ovary	IGROV1	9.9
Ovary	JHOC5	9.9
Ovary	JHOM1	9.5
Ovary	JHOM2B	10.4
Ovary	JHOS2	9.1
Ovary	JHOS4	9.4
Ovary	KURAMOCHI	9.7
Ovary	MCAS	9.9
Ovary	NIHOVCAR3	9.8
Ovary	OAW28	9.8
Ovary	OAW42	9.6
Ovary	OC314	9.9
Ovary	OC316	9.8
Ovary	ONCODG1	10
Ovary	OV56	9.7
Ovary	OV7	8.9
Ovary	OV90	9.6
Ovary	OVCAR4	9.4
Ovary	OVCAR8	10.9
Ovary	OVISE	9.3
Ovary	OVK18	10
Ovary	OVKATE	9.9
Ovary	OVMANA	9.4
Ovary	OVSAHO	9.4
Ovary	OVTOKO	9.5
Ovary	RMGI	9.6
Ovary	RMUGS	9.3
Ovary	SKOV3	10.1
Ovary	SNU119	10.4
Ovary	SNU840	8.9
Ovary	SNU8	9.4
Ovary	TOV112D	9.9
Ovary	TOV21G	9.8
Ovary	TYKNU	9.9
Pancreas	ASPC1	9.4
Pancreas	BXPC3	9.4
Pancreas	CAPAN1	9.3
Pancreas	CAPAN2	9.6
Pancreas	CFPAC1	9.3
Pancreas	DANG	9.4
Pancreas	HPAC	9.9
Pancreas	HPAFII	9.1
Pancreas	HS766T	9.2
Pancreas	HUPT3	9.6
Pancreas	HUPT4	9.3
Pancreas	KCIMOH1	9.7
Pancreas	KLM1	9.7
Pancreas	KP2	9.9
Pancreas	KP3	9.6
Pancreas	KP4	10.1
Pancreas	L33	9.4
Pancreas	MIAPACA2	10
Pancreas	PANC0203	9.9
Pancreas	PANC0213	9.1
Pancreas	PANC0327	10.1
Pancreas	PANC0403	10.2
Pancreas	PANC0504	9.8
Pancreas	PANC0813	9.8
Pancreas	PANC1005	8.9
Pancreas	PANC1	9
Pancreas	PATU8902	9.1
Pancreas	PATU8988S	9.2
Pancreas	PATU8988T	9.5
Pancreas	PK1	9.8
Pancreas	PK45H	10.1
Pancreas	PK59	8.8
Pancreas	PL45	9.1
Pancreas	PSN1	9.7
Pancreas	QGP1	10.1
Pancreas	SNU213	10
Pancreas	SNU324	10
Pancreas	SNU410	9.9
Pancreas	SU8686	9.9
Pancreas	SUIT2	10.1
Pancreas	SW1990	9.2
Pancreas	T3M4	10.3
Pancreas	TCCPAN2	8.9
Pancreas	YAPC	9.9
Pleura	ACCMESO1	9.4
Pleura	DM3	9
Pleura	ISTMES1	9.7
Pleura	ISTMES2	9.9
Pleura	JL1	9.7
Pleura	MPP89	9.4
Pleura	MSTO211H	9.8
Pleura	NCIH2052	9
Pleura	NCIH2452	9.3
Pleura	NCIH28	9.3
Prostate	22RV1	10.6
Prostate	DU145	10.7
Prostate	LNCAPCLONEFGC	9.5
Prostate	MDAPCA2B	9.8
Prostate	NCIH660	9.6
Prostate	PC3	9
Prostate	VCAP	9.7
Salivary gland	A253	9.9
Salivary gland	YD15	9.3
Skin	A101D	9.3
Skin	A2058	9.8
Skin	A375	9.4
Skin	C32	9.7
Skin	CHL1	10.2
Skin	CJM	10.3
Skin	COLO679	9.8
Skin	COLO741	9.6
Skin	COLO783	9.1
Skin	COLO792	9.2
Skin	COLO800	9.4
Skin	COLO818	9.6
Skin	COLO829	9.7
Skin	COLO849	9.4
Skin	G361	10.2
Skin	GRM	9
Skin	HMCB	10.3
Skin	HS294T	9.4
Skin	HS600T	9.2
Skin	HS688AT	9.4
Skin	HS695T	8.7
Skin	HS839T	9.3
Skin	HS852T	10.1
Skin	HS895T	8.9
Skin	HS934T	9.2
Skin	HS936T	8.9
Skin	HS939T	9.4
Skin	HS940T	9
Skin	HS944T	9.3
Skin	HT144	9.6
Skin	IGR1	9.7
Skin	IGR37	9.1
Skin	IGR39	9.1
Skin	IPC298	9.3
Skin	K029AX	8.8
Skin	LOXIMVI	9.1
Skin	MALME3M	9.3
Skin	MDAMB435S	9.1
Skin	MELHO	9.9
Skin	MELJUSO	9.3
Skin	MEWO	10.3
Skin	RPMI7951	9.7
Skin	RVH421	9.3
Skin	SH4	9.8
Skin	SKMEL1	9.2
Skin	SKMEL24	9.2
Skin	SKMEL28	9.4
Skin	SKMEL2	9.8
Skin	SKMEL30	9.9
Skin	SKMEL31	9.7
Skin	SKMEL3	9.3
Skin	SKMEL5	9
Skin	UACC257	8.9
Skin	UACC62	8.7
Skin	WM115	9.6
Skin	WM1799	9.6
Skin	WM2664	9.3
Skin	WM793	9.4
Skin	WM88	9.6
Skin	WM983B	9.8
Small intestine	HUTU80	9.9
Soft tissue	A204	9.7
Soft tissue	G401	10.1
Soft tissue	G402	10.1
Soft tissue	GCT	8.6
Soft tissue	HS729	9.6
Soft tissue	HT1080	9.5
Soft tissue	KYM1	10.3
Soft tissue	MESSA	9.6
Soft tissue	RD	10.5
Soft tissue	RH30	9.7
Soft tissue	RH41	10.8
Soft tissue	RKN	9.2
Soft tissue	S117	10.1
Soft tissue	SJRH30	10.3
Soft tissue	SKLMS1	10
Soft tissue	SKUT1	10.2
Soft tissue	TE125T	9.4
Soft tissue	TE159T	9
Soft tissue	TE441T	9.9
Soft tissue	TE617T	9.7
Stomach	2313287	10.3
Stomach	AGS	10.6
Stomach	AZ521	10.4
Stomach	ECC10	10.2
Stomach	ECC12	10.3
Stomach	FU97	8.6
Stomach	GCIY	9.3
Stomach	GSS	10
Stomach	GSU	10.3
Stomach	HGC27	9.6
Stomach	HS746T	10.1
Stomach	HUG1N	9.6
Stomach	IM95	9.8
Stomach	KATOIII	9.9
Stomach	KE39	9.4
Stomach	LMSU	10.6
Stomach	MKN1	10
Stomach	MKN45	10.7
Stomach	MKN74	10.6
Stomach	MKN7	9.8
Stomach	NCCSTCK140	9.3
Stomach	NCIN87	10.1
Stomach	NUGC2	8.7
Stomach	NUGC3	9.2
Stomach	NUGC4	9.3
Stomach	OCUM1	9.7
Stomach	RERFGC1B	9.7
Stomach	SH10TC	9
Stomach	SNU16	9.3
Stomach	SNU1	10.2
Stomach	SNU216	9
Stomach	SNU520	10
Stomach	SNU5	10.5
Stomach	SNU601	10.2
Stomach	SNU620	9.9
Stomach	SNU668	8.6
Stomach	SNU719	9.7
Stomach	TGBC11TKB	10.2
Thyroid	8305C	8.9
Thyroid	8505C	9.6
Thyroid	BCPAP	9.2
Thyroid	BHT101	9.6
Thyroid	CAL62	10.5
Thyroid	CGTHW1	9.8
Thyroid	FTC133	9.5
Thyroid	FTC238	9.7
Thyroid	ML1	10.3
Thyroid	SW579	9.4
Thyroid	TT2609C02	9.9
Thyroid	TT	9.5
Upper aerodigestive tract	BHY	8.6
Upper aerodigestive tract	BICR16	8.5
Upper aerodigestive tract	BICR18	9.2
Upper aerodigestive tract	BICR22	9.4
Upper aerodigestive tract	BICR31	8.8
Upper aerodigestive tract	BICR56	9.2
Upper aerodigestive tract	BICR6	8.6
Upper aerodigestive tract	CAL27	8.9
Upper aerodigestive tract	CAL33	9.5
Upper aerodigestive tract	DETROIT562	10.4
Upper aerodigestive tract	FADU	9.6
Upper aerodigestive tract	HS840T	9.3
Upper aerodigestive tract	HSC2	9.7
Upper aerodigestive tract	HSC3	9.6
Upper aerodigestive tract	HSC4	8.6
Upper aerodigestive tract	PECAPJ15	9.2
Upper aerodigestive tract	PECAPJ34CLONEC12	9.1
Upper aerodigestive tract	PECAPJ41CLONED2	9.4
Upper aerodigestive tract	PECAPJ49	9.5
Upper aerodigestive tract	SCC15	9.2
Upper aerodigestive tract	SCC25	9.4
Upper aerodigestive tract	SCC4	9.4
Upper aerodigestive tract	SCC9	9.2
Upper aerodigestive tract	SNU1076	8.9
Upper aerodigestive tract	SNU1214	9
Upper aerodigestive tract	SNU46	8.8
Upper aerodigestive tract	SNU899	8.7
Upper aerodigestive tract	YD10B	9.1
Upper aerodigestive tract	YD38	9.3
Upper aerodigestive tract	YD8	8.9
Urinary tract	5637	9.2
Urinary tract	639V	9.6
Urinary tract	647V	10.3
Urinary tract	BC3C	9.6
Urinary tract	BFTC905	8.8
Urinary tract	CAL29	9.4
Urinary tract	HS172T	9.8
Urinary tract	HT1197	9.2
Urinary tract	HT1376	8.9
Urinary tract	J82	8.6
Urinary tract	JMSU1	10.2
Urinary tract	KMBC2	9.5
Urinary tract	KU1919	10.2
Urinary tract	RT11284	9.2
Urinary tract	RT112	8.8
Urinary tract	RT4	9.9
Urinary tract	SCABER	9.7
Urinary tract	SW1710	9.5
Urinary tract	SW780	9.3
Urinary tract	T24	9.3
Urinary tract	TCCSUP	9.5
Urinary tract	UMUC1	8.6
Urinary tract	UMUC3	9.3
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	18.7
Adrenal gland	33.5
Appendix	28.5
Bone marrow	20.4
Breast	21.2
Cerebral cortex	34
Cervix, uterine	26.9
Colon	16.9
Duodenum	14.9
Endometrium	32.7
Epididymis	23.9
Esophagus	15.3
Fallopian tube	23
Gallbladder	29.8
Heart muscle	11.3
Kidney	17.4
Liver	8.4
Lung	40.6
Lymph node	30.6
Ovary	25.4
Pancreas	3.3
Parathyroid gland	40.6
Placenta	31.5
Prostate	27.7
Rectum	19.5
Salivary gland	5
Seminal vesicle	23
Skeletal muscle	4.4
Skin	12.9
Small intestine	18.1
Smooth muscle	26.2
Spleen	31.1
Stomach	14.9
Testis	59
Thyroid gland	37.4
Tonsil	23.7
Urinary bladder	24

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25377162	Overexpression	Breast Carcinoma	In the present study, we found that SMARCA5 was overexpressed in breast cancer specimens by immunohistochemistry.
18519663	Overexpression	Ovarian Carcinoma	Based on immunohistochemistry, we found that Rsf-1 and hSNF2H were co-upregulated in ovarian cancer tissues.

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.527	3.41e-30	37.1	52.2	10.6	Loss
BRCA	Breast invasive carcinoma	1075	0.43	1.56e-49	27.6	61.8	10.6	Neutral
CESC	Cervical and endocervical cancers	292	0.552	1.13e-24	34.9	57.9	7.2	Loss
COAD	Colon adenocarcinoma	449	0.353	1.21e-14	30.1	65.9	4	Neutral
ESCA	Esophageal carcinoma	183	0.611	4e-20	44.3	39.3	16.4	Loss
GBM	Glioblastoma multiforme	147	0.215	0.00876	15.6	79.6	4.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.39	4.42e-20	31.3	59.3	9.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.301	1.94e-12	14.5	82.7	2.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.096	0.104	9.7	87.2	3.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.235	0.00228	1.2	97.6	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.394	1.83e-20	23.6	75.6	0.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.419	6.22e-17	39.8	55.8	4.4	Loss
LUAD	Lung adenocarcinoma	512	0.384	1.85e-19	30.1	58.8	11.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.566	1.76e-43	62.7	31.3	6	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.697	5.34e-45	61	27	12	Loss
PAAD	Pancreatic adenocarcinoma	177	0.423	4.42e-09	15.8	79.1	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.296	0.000128	6.8	90.1	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.077	0.0897	4.5	92.7	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.294	0.000136	40.2	53.7	6.1	Loss
SARC	Sarcoma	255	0.507	4.59e-18	24.3	56.9	18.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.315	6.94e-10	25.3	61	13.6	Neutral
STAD	Stomach adenocarcinoma	413	0.542	6.87e-33	37.3	55.4	7.3	Loss
TGCT	Testicular Germ Cell Tumors	150	0.036	0.659	72	27.3	0.7	Loss
THCA	Thyroid carcinoma	497	0.123	0.00608	0.4	98.6	1	Neutral
THYM	Thymoma	119	0.126	0.173	3.4	95	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.266	3.71e-10	19.2	78.2	2.6	Neutral

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.333	2.44e-12	17	408	0.007	0.000531	NS/NA
BRCA	Breast invasive carcinoma	-0.306	3.08e-20	83	785	0.002	4.88e-09	NS/NA
CESC	Cervical and endocervical cancers	-0.23	4.84e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.23	3.71e-05	19	297	0.026	1.88e-06	NS/NA
ESCA	Esophageal carcinoma	-0.342	1.27e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.171	0.172	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.342	2.85e-16	20	522	0.005	1.48e-12	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.229	1.94e-05	24	319	0.022	1.94e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.322	1.54e-08	23	275	0.012	2.8e-11	NS/NA
LAML	Acute Myeloid Leukemia	-0.098	0.202	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.306	7.89e-13	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.438	0	41	373	0.048	9.04e-49	NS/NA
LUAD	Lung adenocarcinoma	-0.185	5.08e-05	21	456	-0.002	0.212	NS/NA
LUSC	Lung squamous cell carcinoma	-0.324	1.35e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.933	0.00075	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.402	2.25e-08	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.2	0.00615	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.352	5.26e-17	35	498	0.007	1.35e-17	NS/NA
READ	Rectum adenocarcinoma	-0.252	0.0113	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.294	1.35e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.332	1.66e-13	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.222	1.66e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.441	1.25e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.075	0.0747	50	509	0	0.0821	NS/NA
THYM	Thymoma	-0.128	0.158	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.185	6.03e-05	34	431	0.003	5.65e-06	NS/NA

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	3	High
Breast	1	Low
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	0	Not detected
Lung	2	Medium
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	1	Low
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	3	High
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.666	NS	24476821
BRCA	Breast invasive carcinoma	521	4.91e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0614	NS	22810696
GBM	Glioblastoma multiforme	157	0.104	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.603	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.511	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.497	NS	26824661
LUAD	Lung adenocarcinoma	230	0.565	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.00583	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	4.85e-07	Significant	21720365
PRAD	Prostate adenocarcinoma	333	3.48e-21	Significant	26544944
READ	Rectum adenocarcinoma	67	0.037	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.262	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000266	Significant	25079317
THCA	Thyroid carcinoma	391	0.0325	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.792	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.031	0.887	NS
BRCA	Breast invasive carcinoma	1079	1.623	0.0282	Shorter
CESC	Cervical and endocervical cancers	291	2.398	0.0302	Shorter
COAD	Colon adenocarcinoma	439	0.489	0.0148	Longer
ESCA	Esophageal carcinoma	184	1.056	0.857	NS
GBM	Glioblastoma multiforme	158	0.876	0.6	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.268	0.239	NS
KIRC	Kidney renal clear cell carcinoma	531	0.365	3.25e-06	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.902	0.812	NS
LAML	Acute Myeloid Leukemia	149	1.289	0.373	NS
LGG	Brain Lower Grade Glioma	511	1.168	0.564	NS
LIHC	Liver hepatocellular carcinoma	365	1.387	0.194	NS
LUAD	Lung adenocarcinoma	502	1.172	0.435	NS
LUSC	Lung squamous cell carcinoma	494	0.991	0.964	NS
OV	Ovarian serous cystadenocarcinoma	303	0.933	0.746	NS
PAAD	Pancreatic adenocarcinoma	177	1.37	0.268	NS
PCPG	Pheochromocytoma and Paraganglioma	179	501559283.768	0.361	NS
PRAD	Prostate adenocarcinoma	497	2.181	0.395	NS
READ	Rectum adenocarcinoma	159	0.409	0.198	NS
SARC	Sarcoma	259	1.486	0.198	NS
SKCM	Skin Cutaneous Melanoma	459	0.757	0.172	NS
STAD	Stomach adenocarcinoma	388	0.758	0.225	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.317	NS
THCA	Thyroid carcinoma	500	1.89	0.35	NS
THYM	Thymoma	119	0.582	0.529	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.875	0.648	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.033	0.507	NS
BRCA	Breast invasive carcinoma	1071	-0.001	0.986	NS
CESC	Cervical and endocervical cancers	167	0.09	0.246	NS
COAD	Colon adenocarcinoma	445	-0.111	0.0194	Lower
ESCA	Esophageal carcinoma	162	-0.032	0.682	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.01	0.83	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.19	1.05e-05	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.017	0.787	NS
LIHC	Liver hepatocellular carcinoma	347	0.087	0.105	NS
LUAD	Lung adenocarcinoma	507	0.043	0.332	NS
LUSC	Lung squamous cell carcinoma	497	0.067	0.136	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.095	0.0977	NS
PAAD	Pancreatic adenocarcinoma	176	-0.014	0.85	NS
READ	Rectum adenocarcinoma	156	-0.018	0.82	NS
SKCM	Skin Cutaneous Melanoma	410	-0.037	0.45	NS
STAD	Stomach adenocarcinoma	392	0.068	0.179	NS
TGCT	Testicular Germ Cell Tumors	81	-0.128	0.256	NS
THCA	Thyroid carcinoma	499	-0.038	0.401	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.005	0.911	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.011	0.855	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.062	0.165	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.198	5.08e-06	Lower
LGG	Brain Lower Grade Glioma	514	0.007	0.87	NS
LIHC	Liver hepatocellular carcinoma	366	0.033	0.531	NS
OV	Ovarian serous cystadenocarcinoma	296	0.003	0.958	NS
PAAD	Pancreatic adenocarcinoma	176	0.044	0.566	NS
STAD	Stomach adenocarcinoma	406	-0.053	0.282	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.226	1.26e-07	Higher

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB02379	Beta-D-Glucose	Small Molecule Drug
DB02670	4-Deoxy-Alpha-D-Glucose	Small Molecule Drug

Summary
Symbol	SMARCA5
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases	hSNF2H; hISWI; SNF2H; WCRF135; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ......
Location	4q31.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25377162	Breast Carcinoma	partner	Rsf-1	Correlation	SMARCA5 overexpression also correlated with Rsf-1 expression levels