CR2Cancer

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00505 HMG (high mobility group) box

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	12672490

> Gene Ontology [ TOP ]
Biological Process	GO:0006333 chromatin assembly or disassembly GO:0006337 nucleosome disassembly GO:0006338 chromatin remodeling GO:0031498 chromatin disassembly GO:0032984 macromolecular complex disassembly GO:0032986 protein-DNA complex disassembly GO:0034728 nucleosome organization GO:0043044 ATP-dependent chromatin remodeling GO:0043241 protein complex disassembly GO:0071824 protein-DNA complex subunit organization
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016922 ligand-dependent nuclear receptor binding GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0047485 protein N-terminus binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016514 SWI/SNF complex GO:0017053 transcriptional repressor complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0071564 npBAF complex GO:0071565 nBAF complex GO:0090544 BAF-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214858: RMTs methylate histone arginines

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC) [ TOP ]
There is no record for SMARCE1.

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
26803492	mutation (loss of function)	Meningioma	Heterozygous loss-of-function germline mutations in the SMARCE1 gene are causative, giving rise to an autosomal dominant inheritance pattern. Because of the few reported cases so far, the lifetime risk of developing meningiomas for SMARCE1 mutation carriers is unclear and the complete tumor spectrum is unknown.
25143307	loss of expression (mutation)	Spinal Multifocal Clear Cell Meningioma; Cranial Clear Cell Meningioma	Copy number analysis identified a large deletion of the 5' end of SMARCE1 in two unrelated probands with spinal clear cell meningiomas. In addition, we found loss of SMARCE1 protein in three of 10 paraffin-embedded cranial clear cell meningiomas.
23377182	mutation (loss of function)	Clear Cell Meningioma	We identified two individuals with heterozygous loss-of-function mutations in the SWI/SNF chromatin-remodeling complex subunit gene SMARCE1. Sequencing of SMARCE1 in six further individuals with spinal meningiomas identified two additional heterozygous loss-of-function mutations. Tumors from individuals with SMARCE1 mutations were of clear-cell histological subtype, and all had loss of SMARCE1 protein, consistent with a tumor suppressor mechanism.
21465167	mutation	Breast Carcinoma	Here, we describe two novel mutations in the BAF57 gene found in a breast cancer patient.
16538531	mutation (loss of function)	Breast Carcinoma	The absence of wild-type BAF57 alleles indicates that this is a biallelic inactivating mutation that causes a frameshift and as a consequence a premature stop codon leading to a truncated BAF57 protein.

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q969G3	40	R	Omega-N-methylarginine	-	No	None detected
Q969G3	265	S	Phosphoserine	-	No	None detected

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.176	7.357	0.209	0.11	NS
BRCA	Breast invasive carcinoma	112	1100	7.154	7.328	0.228	0.000136	NS
CESC	Cervical and endocervical cancers	3	306	7.715	6.933	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.767	6.951	0.101	0.275	NS
ESCA	Esophageal carcinoma	11	185	6.28	6.479	0.343	0.25	NS
GBM	Glioblastoma multiforme	5	166	5.704	6.992	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.582	6.631	0.016	0.816	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.984	6.978	-0.017	0.642	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.727	7.28	0.471	5.76e-09	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.042	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.616	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.818	6.23	0.465	4.15e-11	NS
LUAD	Lung adenocarcinoma	59	517	6.887	7.072	0.15	0.0148	NS
LUSC	Lung squamous cell carcinoma	51	501	6.835	6.975	0.144	0.044	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.404	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.927	6.718	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.47	6.828	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.071	7.146	0.023	0.67	NS
READ	Rectum adenocarcinoma	10	167	6.977	6.894	-0.225	0.264	NS
SARC	Sarcoma	2	263	6.87	6.958	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.18	6.837	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.429	6.566	0.208	0.14	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.399	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.872	6.968	0.096	0.000314	NS
THYM	Thymoma	2	120	7.472	7.787	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.618	7.273	-0.23	0.0214	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.8
Autonomic ganglia	CHP212	12.5
Autonomic ganglia	IMR32	11.3
Autonomic ganglia	KELLY	11.8
Autonomic ganglia	KPNRTBM1	12.1
Autonomic ganglia	KPNSI9S	11.1
Autonomic ganglia	KPNYN	12.1
Autonomic ganglia	MHHNB11	10.7
Autonomic ganglia	NB1	11.5
Autonomic ganglia	NH6	12
Autonomic ganglia	SHSY5Y	11.9
Autonomic ganglia	SIMA	12.3
Autonomic ganglia	SKNAS	11.2
Autonomic ganglia	SKNBE2	12.1
Autonomic ganglia	SKNDZ	12
Autonomic ganglia	SKNFI	11.5
Autonomic ganglia	SKNSH	11.3
Biliary tract	HUCCT1	11.1
Biliary tract	HUH28	10.6
Biliary tract	SNU1079	11.4
Biliary tract	SNU1196	10.3
Biliary tract	SNU245	10.3
Biliary tract	SNU308	10.3
Biliary tract	SNU478	10.8
Bone	143B	11
Bone	A673	10.2
Bone	CADOES1	11.3
Bone	CAL78	10.3
Bone	G292CLONEA141B1	11.7
Bone	HOS	11
Bone	HS706T	10.6
Bone	HS737T	10.8
Bone	HS819T	11
Bone	HS821T	10.7
Bone	HS822T	10.9
Bone	HS863T	10.6
Bone	HS870T	11
Bone	HS888T	10.8
Bone	MG63	12
Bone	MHHES1	10.5
Bone	OUMS27	10.8
Bone	RDES	11.8
Bone	SJSA1	11.2
Bone	SKES1	10.9
Bone	SKNMC	11.4
Bone	SW1353	10.9
Bone	T173	10.7
Bone	TC71	10.7
Bone	U2OS	10.5
Breast	AU565	11.6
Breast	BT20	9.7
Breast	BT474	11.1
Breast	BT483	11.7
Breast	BT549	6.5
Breast	CAL120	10.9
Breast	CAL148	12
Breast	CAL51	12
Breast	CAL851	10.3
Breast	CAMA1	11.5
Breast	DU4475	10.9
Breast	EFM192A	11.8
Breast	EFM19	12.1
Breast	EVSAT	11.6
Breast	HCC1143	9.4
Breast	HCC1187	11.2
Breast	HCC1395	10.7
Breast	HCC1419	10.1
Breast	HCC1428	10.2
Breast	HCC1500	10.5
Breast	HCC1569	10.8
Breast	HCC1599	11.4
Breast	HCC1806	11
Breast	HCC1937	10.4
Breast	HCC1954	10.7
Breast	HCC202	10.7
Breast	HCC2157	10.5
Breast	HCC2218	10.1
Breast	HCC38	11.4
Breast	HCC70	9.9
Breast	HDQP1	11.6
Breast	HMC18	11.3
Breast	HS274T	10.5
Breast	HS281T	10.8
Breast	HS343T	10.5
Breast	HS578T	9.4
Breast	HS606T	10.9
Breast	HS739T	10.8
Breast	HS742T	10.7
Breast	JIMT1	9.4
Breast	KPL1	10.7
Breast	MCF7	10.7
Breast	MDAMB134VI	11.8
Breast	MDAMB157	11.5
Breast	MDAMB175VII	11
Breast	MDAMB231	10.7
Breast	MDAMB361	10.2
Breast	MDAMB415	11
Breast	MDAMB436	9.7
Breast	MDAMB453	10
Breast	MDAMB468	10.6
Breast	SKBR3	12.2
Breast	T47D	11.7
Breast	UACC812	12.5
Breast	UACC893	10.5
Breast	YMB1	11.1
Breast	ZR751	11.5
Breast	ZR7530	10.6
Central nervous system	1321N1	10.6
Central nervous system	42MGBA	10.2
Central nervous system	8MGBA	10.6
Central nervous system	A172	11.4
Central nervous system	AM38	11.3
Central nervous system	BECKER	10.3
Central nervous system	CAS1	11.8
Central nervous system	CCFSTTG1	10.6
Central nervous system	D283MED	11.8
Central nervous system	D341MED	12.2
Central nervous system	DAOY	11.3
Central nervous system	DBTRG05MG	11.1
Central nervous system	DKMG	11.2
Central nervous system	GAMG	10.9
Central nervous system	GB1	10.5
Central nervous system	GI1	10.9
Central nervous system	GMS10	10.3
Central nervous system	GOS3	11.4
Central nervous system	H4	10.2
Central nervous system	HS683	11.1
Central nervous system	KALS1	10.4
Central nervous system	KG1C	11.2
Central nervous system	KNS42	11.2
Central nervous system	KNS60	10.4
Central nervous system	KNS81	11.6
Central nervous system	KS1	11.5
Central nervous system	LN18	10.5
Central nervous system	LN229	10.7
Central nervous system	M059K	9.3
Central nervous system	MOGGCCM	9.9
Central nervous system	MOGGUVW	10.5
Central nervous system	NMCG1	10.7
Central nervous system	ONS76	11.4
Central nervous system	SF126	11.1
Central nervous system	SF295	10.9
Central nervous system	SNB19	10.6
Central nervous system	SNU1105	10.7
Central nervous system	SNU201	11
Central nervous system	SNU466	11
Central nervous system	SNU489	11.2
Central nervous system	SNU626	11.5
Central nervous system	SNU738	10.8
Central nervous system	SW1088	10.5
Central nervous system	SW1783	11.1
Central nervous system	T98G	11.5
Central nervous system	TM31	10.9
Central nervous system	U118MG	10.6
Central nervous system	U138MG	10.7
Central nervous system	U251MG	11.5
Central nervous system	U87MG	10.7
Central nervous system	YH13	11.1
Central nervous system	YKG1	12.1
Endometrium	AN3CA	11.2
Endometrium	COLO684	10.6
Endometrium	EFE184	10.8
Endometrium	EN	10
Endometrium	ESS1	11.3
Endometrium	HEC108	11.3
Endometrium	HEC151	11.5
Endometrium	HEC1A	11.5
Endometrium	HEC1B	11.1
Endometrium	HEC251	11
Endometrium	HEC265	10.9
Endometrium	HEC50B	10.6
Endometrium	HEC59	11.7
Endometrium	HEC6	10.8
Endometrium	ISHIKAWAHERAKLIO02ER	11.3
Endometrium	JHUEM1	10.8
Endometrium	JHUEM2	11.5
Endometrium	JHUEM3	11.4
Endometrium	KLE	10.1
Endometrium	MFE280	11
Endometrium	MFE296	11.3
Endometrium	MFE319	11
Endometrium	RL952	10.7
Endometrium	SNGM	11.7
Endometrium	SNU1077	10.8
Endometrium	SNU685	11.1
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	11.8
Haematopoietic and lymphoid	A3KAW	10.8
Haematopoietic and lymphoid	A4FUK	10.8
Haematopoietic and lymphoid	ALLSIL	12
Haematopoietic and lymphoid	AML193	11.6
Haematopoietic and lymphoid	AMO1	11.1
Haematopoietic and lymphoid	BCP1	11.1
Haematopoietic and lymphoid	BDCM	10.9
Haematopoietic and lymphoid	BL41	11
Haematopoietic and lymphoid	BL70	11.4
Haematopoietic and lymphoid	BV173	12
Haematopoietic and lymphoid	CA46	10.9
Haematopoietic and lymphoid	CI1	11
Haematopoietic and lymphoid	CMK115	11.8
Haematopoietic and lymphoid	CMK86	11.3
Haematopoietic and lymphoid	CMK	11.2
Haematopoietic and lymphoid	CMLT1	11.7
Haematopoietic and lymphoid	COLO775	10.4
Haematopoietic and lymphoid	DAUDI	11
Haematopoietic and lymphoid	DB	11.3
Haematopoietic and lymphoid	DEL	10.3
Haematopoietic and lymphoid	DND41	11.5
Haematopoietic and lymphoid	DOHH2	11.5
Haematopoietic and lymphoid	EB1	11.1
Haematopoietic and lymphoid	EB2	11
Haematopoietic and lymphoid	EHEB	10.9
Haematopoietic and lymphoid	EJM	10.1
Haematopoietic and lymphoid	EM2	12.1
Haematopoietic and lymphoid	EOL1	11.2
Haematopoietic and lymphoid	F36P	11.2
Haematopoietic and lymphoid	GA10	11.3
Haematopoietic and lymphoid	GDM1	11.5
Haematopoietic and lymphoid	GRANTA519	11.3
Haematopoietic and lymphoid	HDLM2	11.1
Haematopoietic and lymphoid	HDMYZ	6.8
Haematopoietic and lymphoid	HEL9217	11.3
Haematopoietic and lymphoid	HEL	11.3
Haematopoietic and lymphoid	HH	11.3
Haematopoietic and lymphoid	HL60	11
Haematopoietic and lymphoid	HPBALL	11.4
Haematopoietic and lymphoid	HS604T	10.4
Haematopoietic and lymphoid	HS611T	11.2
Haematopoietic and lymphoid	HS616T	10.8
Haematopoietic and lymphoid	HS751T	11.1
Haematopoietic and lymphoid	HT	11.1
Haematopoietic and lymphoid	HTK	10.9
Haematopoietic and lymphoid	HUNS1	11.1
Haematopoietic and lymphoid	HUT102	11.2
Haematopoietic and lymphoid	HUT78	11.3
Haematopoietic and lymphoid	JEKO1	11.4
Haematopoietic and lymphoid	JK1	11
Haematopoietic and lymphoid	JM1	11.9
Haematopoietic and lymphoid	JURKAT	11.3
Haematopoietic and lymphoid	JURLMK1	10.7
Haematopoietic and lymphoid	JVM2	10.8
Haematopoietic and lymphoid	JVM3	11.1
Haematopoietic and lymphoid	K562	10.4
Haematopoietic and lymphoid	KARPAS299	11
Haematopoietic and lymphoid	KARPAS422	10.2
Haematopoietic and lymphoid	KARPAS620	11.4
Haematopoietic and lymphoid	KASUMI1	11.3
Haematopoietic and lymphoid	KASUMI2	12.1
Haematopoietic and lymphoid	KASUMI6	11.3
Haematopoietic and lymphoid	KCL22	11.1
Haematopoietic and lymphoid	KE37	12
Haematopoietic and lymphoid	KE97	11.6
Haematopoietic and lymphoid	KG1	11.9
Haematopoietic and lymphoid	KHM1B	10.9
Haematopoietic and lymphoid	KIJK	10.6
Haematopoietic and lymphoid	KMH2	11.4
Haematopoietic and lymphoid	KMM1	11.3
Haematopoietic and lymphoid	KMS11	11.3
Haematopoietic and lymphoid	KMS12BM	11.3
Haematopoietic and lymphoid	KMS18	11.5
Haematopoietic and lymphoid	KMS20	10.7
Haematopoietic and lymphoid	KMS21BM	10.9
Haematopoietic and lymphoid	KMS26	11.2
Haematopoietic and lymphoid	KMS27	11.3
Haematopoietic and lymphoid	KMS28BM	10.8
Haematopoietic and lymphoid	KMS34	11.1
Haematopoietic and lymphoid	KO52	12.1
Haematopoietic and lymphoid	KOPN8	11.3
Haematopoietic and lymphoid	KU812	11.5
Haematopoietic and lymphoid	KYO1	10.4
Haematopoietic and lymphoid	L1236	10.9
Haematopoietic and lymphoid	L363	10.5
Haematopoietic and lymphoid	L428	11.7
Haematopoietic and lymphoid	L540	11.6
Haematopoietic and lymphoid	LAMA84	11.7
Haematopoietic and lymphoid	LOUCY	12.2
Haematopoietic and lymphoid	LP1	10.8
Haematopoietic and lymphoid	M07E	11.7
Haematopoietic and lymphoid	MC116	10.8
Haematopoietic and lymphoid	ME1	11.1
Haematopoietic and lymphoid	MEC1	11.3
Haematopoietic and lymphoid	MEC2	10.6
Haematopoietic and lymphoid	MEG01	10.8
Haematopoietic and lymphoid	MHHCALL2	11.6
Haematopoietic and lymphoid	MHHCALL3	11.8
Haematopoietic and lymphoid	MHHCALL4	11.9
Haematopoietic and lymphoid	MINO	11.4
Haematopoietic and lymphoid	MJ	11.4
Haematopoietic and lymphoid	MM1S	11.2
Haematopoietic and lymphoid	MOLM13	11.1
Haematopoietic and lymphoid	MOLM16	11.4
Haematopoietic and lymphoid	MOLM6	11.2
Haematopoietic and lymphoid	MOLP2	10.7
Haematopoietic and lymphoid	MOLP8	10.6
Haematopoietic and lymphoid	MOLT13	12.1
Haematopoietic and lymphoid	MOLT16	11.7
Haematopoietic and lymphoid	MOLT4	11.9
Haematopoietic and lymphoid	MONOMAC1	10.5
Haematopoietic and lymphoid	MONOMAC6	10.4
Haematopoietic and lymphoid	MOTN1	11.4
Haematopoietic and lymphoid	MUTZ5	11.7
Haematopoietic and lymphoid	MV411	10.7
Haematopoietic and lymphoid	NALM19	12.1
Haematopoietic and lymphoid	NALM1	11.5
Haematopoietic and lymphoid	NALM6	11.8
Haematopoietic and lymphoid	NAMALWA	10.7
Haematopoietic and lymphoid	NB4	11.4
Haematopoietic and lymphoid	NCIH929	10.2
Haematopoietic and lymphoid	NCO2	11.2
Haematopoietic and lymphoid	NOMO1	11.1
Haematopoietic and lymphoid	NUDHL1	10.9
Haematopoietic and lymphoid	NUDUL1	11.7
Haematopoietic and lymphoid	OCIAML2	10.7
Haematopoietic and lymphoid	OCIAML3	10.5
Haematopoietic and lymphoid	OCIAML5	11.1
Haematopoietic and lymphoid	OCILY10	9.8
Haematopoietic and lymphoid	OCILY19	11.3
Haematopoietic and lymphoid	OCILY3	11.5
Haematopoietic and lymphoid	OCIM1	11.3
Haematopoietic and lymphoid	OPM2	10.7
Haematopoietic and lymphoid	P12ICHIKAWA	11.6
Haematopoietic and lymphoid	P31FUJ	11
Haematopoietic and lymphoid	P3HR1	11.2
Haematopoietic and lymphoid	PCM6	10.7
Haematopoietic and lymphoid	PEER	11.8
Haematopoietic and lymphoid	PF382	11.8
Haematopoietic and lymphoid	PFEIFFER	11.4
Haematopoietic and lymphoid	PL21	10.8
Haematopoietic and lymphoid	RAJI	10.9
Haematopoietic and lymphoid	RCHACV	11.9
Haematopoietic and lymphoid	REC1	11.1
Haematopoietic and lymphoid	REH	11.9
Haematopoietic and lymphoid	RI1	11.5
Haematopoietic and lymphoid	RL	11.1
Haematopoietic and lymphoid	RPMI8226	10.6
Haematopoietic and lymphoid	RPMI8402	11.7
Haematopoietic and lymphoid	RS411	11.6
Haematopoietic and lymphoid	SEM	11.7
Haematopoietic and lymphoid	SET2	11.4
Haematopoietic and lymphoid	SIGM5	11.1
Haematopoietic and lymphoid	SKM1	11.2
Haematopoietic and lymphoid	SKMM2	11.2
Haematopoietic and lymphoid	SR786	11.3
Haematopoietic and lymphoid	ST486	11.6
Haematopoietic and lymphoid	SUDHL10	11.1
Haematopoietic and lymphoid	SUDHL1	11.8
Haematopoietic and lymphoid	SUDHL4	10.8
Haematopoietic and lymphoid	SUDHL5	11.1
Haematopoietic and lymphoid	SUDHL6	11.2
Haematopoietic and lymphoid	SUDHL8	11.1
Haematopoietic and lymphoid	SUPB15	12
Haematopoietic and lymphoid	SUPHD1	10.7
Haematopoietic and lymphoid	SUPM2	11
Haematopoietic and lymphoid	SUPT11	10.9
Haematopoietic and lymphoid	SUPT1	11.2
Haematopoietic and lymphoid	TALL1	11.7
Haematopoietic and lymphoid	TF1	10.4
Haematopoietic and lymphoid	THP1	10.9
Haematopoietic and lymphoid	TO175T	10.8
Haematopoietic and lymphoid	TOLEDO	12.2
Haematopoietic and lymphoid	U266B1	10.9
Haematopoietic and lymphoid	U937	10.6
Haematopoietic and lymphoid	UT7	11.3
Haematopoietic and lymphoid	WSUDLCL2	10.9
Kidney	769P	11.7
Kidney	786O	10.9
Kidney	A498	11.2
Kidney	A704	10.9
Kidney	ACHN	11.3
Kidney	BFTC909	10.7
Kidney	CAKI1	10.9
Kidney	CAKI2	11.3
Kidney	CAL54	11.5
Kidney	KMRC1	11.3
Kidney	KMRC20	11.3
Kidney	KMRC2	11.3
Kidney	KMRC3	10.8
Kidney	OSRC2	11.3
Kidney	RCC10RGB	10.9
Kidney	SNU1272	11.3
Kidney	SNU349	10.1
Kidney	TUHR10TKB	11
Kidney	TUHR14TKB	11
Kidney	TUHR4TKB	11.1
Kidney	VMRCRCW	10.8
Kidney	VMRCRCZ	11.6
Large intestine	C2BBE1	10.8
Large intestine	CCK81	11.4
Large intestine	CL11	11
Large intestine	CL14	10.5
Large intestine	CL34	10.5
Large intestine	CL40	10.7
Large intestine	COLO205	11
Large intestine	COLO320	11.1
Large intestine	COLO678	12.5
Large intestine	CW2	10.6
Large intestine	DLD1	10.5
Large intestine	GP2D	10.8
Large intestine	HCC56	10.9
Large intestine	HCT116	11.6
Large intestine	HCT15	11
Large intestine	HS675T	10.8
Large intestine	HS698T	10.5
Large intestine	HT115	10.5
Large intestine	HT29	10.6
Large intestine	HT55	10.3
Large intestine	KM12	10.1
Large intestine	LOVO	11.2
Large intestine	LS1034	10.5
Large intestine	LS123	10
Large intestine	LS180	10.4
Large intestine	LS411N	10.7
Large intestine	LS513	11.1
Large intestine	MDST8	11.2
Large intestine	NCIH508	11.3
Large intestine	NCIH716	10.1
Large intestine	NCIH747	10.5
Large intestine	OUMS23	10.1
Large intestine	RCM1	9.6
Large intestine	RKO	10.9
Large intestine	SKCO1	11
Large intestine	SNU1040	10.1
Large intestine	SNU1197	10.2
Large intestine	SNU175	10.9
Large intestine	SNU283	10.9
Large intestine	SNU407	10.6
Large intestine	SNU503	10.4
Large intestine	SNU61	10.4
Large intestine	SNU81	10.9
Large intestine	SNUC1	10.5
Large intestine	SNUC2A	11.1
Large intestine	SNUC4	11.2
Large intestine	SNUC5	10.7
Large intestine	SW1116	10.5
Large intestine	SW1417	10.6
Large intestine	SW1463	11.1
Large intestine	SW403	11.6
Large intestine	SW480	11
Large intestine	SW48	11.1
Large intestine	SW620	11.2
Large intestine	SW837	10.7
Large intestine	SW948	11.2
Large intestine	T84	10.2
Liver	ALEXANDERCELLS	10.9
Liver	C3A	10.5
Liver	HEP3B217	11.1
Liver	HEPG2	11
Liver	HLE	11.2
Liver	HLF	10.7
Liver	HUH1	10.3
Liver	HUH6	10.9
Liver	HUH7	10.8
Liver	JHH1	10.7
Liver	JHH2	10
Liver	JHH4	11.3
Liver	JHH5	10.8
Liver	JHH6	10.6
Liver	JHH7	11.4
Liver	LI7	11.2
Liver	PLCPRF5	10.9
Liver	SKHEP1	11.6
Liver	SNU182	10.7
Liver	SNU387	10.7
Liver	SNU398	10.9
Liver	SNU423	10.7
Liver	SNU449	11.2
Liver	SNU475	11
Liver	SNU761	10.5
Liver	SNU878	11
Liver	SNU886	11.3
Lung	A549	11.1
Lung	ABC1	11
Lung	BEN	9.9
Lung	CAL12T	11
Lung	CALU1	10.5
Lung	CALU3	12.9
Lung	CALU6	9.8
Lung	CHAGOK1	11.4
Lung	COLO668	11
Lung	COLO699	10.9
Lung	CORL105	10.4
Lung	CORL23	9.2
Lung	CORL24	11.3
Lung	CORL279	10.9
Lung	CORL311	11.4
Lung	CORL47	11.3
Lung	CORL51	12.2
Lung	CORL88	10.7
Lung	CORL95	11.3
Lung	CPCN	12
Lung	DMS114	11.5
Lung	DMS153	12
Lung	DMS273	10.8
Lung	DMS454	11
Lung	DMS53	10
Lung	DMS79	12.4
Lung	DV90	10.7
Lung	EBC1	11.2
Lung	EPLC272H	10.4
Lung	HARA	11.3
Lung	HCC1171	11.5
Lung	HCC1195	9.5
Lung	HCC15	11.3
Lung	HCC2279	10.4
Lung	HCC2935	10.7
Lung	HCC33	11.8
Lung	HCC366	10.9
Lung	HCC4006	9.7
Lung	HCC44	10.7
Lung	HCC78	11
Lung	HCC827	10.8
Lung	HCC95	11.5
Lung	HLC1	11.1
Lung	HLFA	10.9
Lung	HS229T	11.2
Lung	HS618T	11.1
Lung	IALM	11.1
Lung	KNS62	10.2
Lung	LC1F	10.9
Lung	LC1SQSF	10.4
Lung	LCLC103H	10.6
Lung	LCLC97TM1	11.5
Lung	LK2	11.5
Lung	LOUNH91	10.6
Lung	LU65	10.4
Lung	LU99	11.1
Lung	LUDLU1	10.7
Lung	LXF289	10.5
Lung	MORCPR	10.7
Lung	NCIH1048	12
Lung	NCIH1092	11.9
Lung	NCIH1105	11.9
Lung	NCIH1155	11.7
Lung	NCIH1184	12.8
Lung	NCIH1299	10
Lung	NCIH1339	10.4
Lung	NCIH1341	11.2
Lung	NCIH1355	10.1
Lung	NCIH1373	10.5
Lung	NCIH1385	11.8
Lung	NCIH1395	10.1
Lung	NCIH1435	10.2
Lung	NCIH1436	11.9
Lung	NCIH1437	10.6
Lung	NCIH146	11.6
Lung	NCIH1563	11.9
Lung	NCIH1568	10.2
Lung	NCIH1573	10.9
Lung	NCIH1581	11.3
Lung	NCIH1618	12.6
Lung	NCIH1623	11.2
Lung	NCIH1648	10.4
Lung	NCIH1650	10.1
Lung	NCIH1651	10.1
Lung	NCIH1666	11.2
Lung	NCIH1693	9
Lung	NCIH1694	11.9
Lung	NCIH1703	11.2
Lung	NCIH1734	10.8
Lung	NCIH1755	11
Lung	NCIH1781	11
Lung	NCIH1792	10.5
Lung	NCIH1793	10.2
Lung	NCIH1836	10.8
Lung	NCIH1838	10.9
Lung	NCIH1869	10.8
Lung	NCIH1876	11.3
Lung	NCIH1915	9.9
Lung	NCIH1930	11.7
Lung	NCIH1944	10.2
Lung	NCIH1963	12
Lung	NCIH196	10.6
Lung	NCIH1975	10
Lung	NCIH2009	11.1
Lung	NCIH2023	10.8
Lung	NCIH2029	11.4
Lung	NCIH2030	9.9
Lung	NCIH2066	11.3
Lung	NCIH2081	11.6
Lung	NCIH2085	10.9
Lung	NCIH2087	9.6
Lung	NCIH209	11.6
Lung	NCIH2106	12
Lung	NCIH2110	11.1
Lung	NCIH211	11.8
Lung	NCIH2122	10.8
Lung	NCIH2126	10.8
Lung	NCIH2141	11.9
Lung	NCIH2170	11
Lung	NCIH2171	11.2
Lung	NCIH2172	10.6
Lung	NCIH2196	10.5
Lung	NCIH2227	11.4
Lung	NCIH2228	10.4
Lung	NCIH226	11.4
Lung	NCIH2286	10.9
Lung	NCIH2291	9.3
Lung	NCIH2342	11.5
Lung	NCIH2347	10.6
Lung	NCIH23	11.1
Lung	NCIH2405	10.7
Lung	NCIH2444	10.5
Lung	NCIH292	10.4
Lung	NCIH322	10.5
Lung	NCIH3255	10.3
Lung	NCIH358	10.2
Lung	NCIH441	10.5
Lung	NCIH446	9.9
Lung	NCIH460	11.1
Lung	NCIH510	11.4
Lung	NCIH520	10.8
Lung	NCIH522	11.7
Lung	NCIH524	11.5
Lung	NCIH526	11.4
Lung	NCIH596	9.7
Lung	NCIH647	10.7
Lung	NCIH650	11.1
Lung	NCIH661	10.6
Lung	NCIH69	11.4
Lung	NCIH727	10
Lung	NCIH810	11.6
Lung	NCIH82	10.6
Lung	NCIH838	10.7
Lung	NCIH841	10.3
Lung	NCIH854	10.6
Lung	NCIH889	11.2
Lung	PC14	10.8
Lung	RERFLCAD1	10.8
Lung	RERFLCAD2	10.8
Lung	RERFLCAI	10.8
Lung	RERFLCKJ	11
Lung	RERFLCMS	10.7
Lung	RERFLCSQ1	10.7
Lung	SBC5	11.1
Lung	SCLC21H	11.8
Lung	SHP77	11
Lung	SKLU1	11
Lung	SKMES1	10.8
Lung	SQ1	10.9
Lung	SW1271	10.1
Lung	SW1573	10.9
Lung	SW900	10.4
Lung	VMRCLCD	11.1
Lung	VMRCLCP	10.2
Oesophagus	COLO680N	10.5
Oesophagus	ECGI10	9.9
Oesophagus	KYSE140	10.7
Oesophagus	KYSE150	10.3
Oesophagus	KYSE180	10.4
Oesophagus	KYSE270	10.3
Oesophagus	KYSE30	11
Oesophagus	KYSE410	10.5
Oesophagus	KYSE450	11.3
Oesophagus	KYSE510	10.7
Oesophagus	KYSE520	10.7
Oesophagus	KYSE70	10.7
Oesophagus	OE19	10.6
Oesophagus	OE33	9.9
Oesophagus	TE10	10
Oesophagus	TE11	10.1
Oesophagus	TE14	10.5
Oesophagus	TE15	10.3
Oesophagus	TE1	10.2
Oesophagus	TE4	10.5
Oesophagus	TE5	12.1
Oesophagus	TE6	12.8
Oesophagus	TE8	10.3
Oesophagus	TE9	10.4
Oesophagus	TT	10.6
Ovary	59M	10.9
Ovary	A2780	11.4
Ovary	CAOV3	10
Ovary	CAOV4	11.2
Ovary	COLO704	11.4
Ovary	COV318	11
Ovary	COV362	10.6
Ovary	COV434	11.2
Ovary	COV504	10.5
Ovary	COV644	10.8
Ovary	EFO21	11.5
Ovary	EFO27	11
Ovary	ES2	11.1
Ovary	FUOV1	11.1
Ovary	HEYA8	11.1
Ovary	HS571T	10.6
Ovary	IGROV1	11.2
Ovary	JHOC5	11
Ovary	JHOM1	11
Ovary	JHOM2B	9.8
Ovary	JHOS2	10.7
Ovary	JHOS4	10.1
Ovary	KURAMOCHI	10.1
Ovary	MCAS	11.1
Ovary	NIHOVCAR3	10.1
Ovary	OAW28	11.2
Ovary	OAW42	11.7
Ovary	OC314	11.2
Ovary	OC316	11.2
Ovary	ONCODG1	10.5
Ovary	OV56	10
Ovary	OV7	10.8
Ovary	OV90	10.5
Ovary	OVCAR4	10.4
Ovary	OVCAR8	11.1
Ovary	OVISE	11.3
Ovary	OVK18	11.3
Ovary	OVKATE	10.4
Ovary	OVMANA	11.5
Ovary	OVSAHO	10.8
Ovary	OVTOKO	11.4
Ovary	RMGI	11.4
Ovary	RMUGS	10.7
Ovary	SKOV3	11.8
Ovary	SNU119	10.5
Ovary	SNU840	10.7
Ovary	SNU8	11.1
Ovary	TOV112D	11.3
Ovary	TOV21G	11.3
Ovary	TYKNU	10.2
Pancreas	ASPC1	10.3
Pancreas	BXPC3	9.7
Pancreas	CAPAN1	11
Pancreas	CAPAN2	10.1
Pancreas	CFPAC1	10.7
Pancreas	DANG	10.9
Pancreas	HPAC	11
Pancreas	HPAFII	9.7
Pancreas	HS766T	10.6
Pancreas	HUPT3	11.1
Pancreas	HUPT4	11.2
Pancreas	KCIMOH1	11
Pancreas	KLM1	10.1
Pancreas	KP2	11.5
Pancreas	KP3	10.5
Pancreas	KP4	11.7
Pancreas	L33	10.2
Pancreas	MIAPACA2	10.9
Pancreas	PANC0203	10.3
Pancreas	PANC0213	9.6
Pancreas	PANC0327	10.9
Pancreas	PANC0403	10.1
Pancreas	PANC0504	11.1
Pancreas	PANC0813	11.2
Pancreas	PANC1005	11
Pancreas	PANC1	11.2
Pancreas	PATU8902	11.2
Pancreas	PATU8988S	10.2
Pancreas	PATU8988T	11.3
Pancreas	PK1	10.4
Pancreas	PK45H	10.9
Pancreas	PK59	10.4
Pancreas	PL45	11
Pancreas	PSN1	10.7
Pancreas	QGP1	11.2
Pancreas	SNU213	11.1
Pancreas	SNU324	11.1
Pancreas	SNU410	10.4
Pancreas	SU8686	10
Pancreas	SUIT2	11.4
Pancreas	SW1990	11.3
Pancreas	T3M4	11.2
Pancreas	TCCPAN2	10.6
Pancreas	YAPC	11.3
Pleura	ACCMESO1	10.6
Pleura	DM3	11.4
Pleura	ISTMES1	11.1
Pleura	ISTMES2	11.5
Pleura	JL1	10.9
Pleura	MPP89	10.7
Pleura	MSTO211H	10.8
Pleura	NCIH2052	11.2
Pleura	NCIH2452	11.6
Pleura	NCIH28	11.6
Prostate	22RV1	11.4
Prostate	DU145	11
Prostate	LNCAPCLONEFGC	11.2
Prostate	MDAPCA2B	11.6
Prostate	NCIH660	11.8
Prostate	PC3	10.2
Prostate	VCAP	12.1
Salivary gland	A253	10.9
Salivary gland	YD15	10.7
Skin	A101D	10.4
Skin	A2058	10.5
Skin	A375	10.6
Skin	C32	10.9
Skin	CHL1	11.8
Skin	CJM	10.8
Skin	COLO679	10.5
Skin	COLO741	10.5
Skin	COLO783	10.1
Skin	COLO792	10.8
Skin	COLO800	10.9
Skin	COLO818	10.8
Skin	COLO829	10.5
Skin	COLO849	10.5
Skin	G361	10.4
Skin	GRM	10.5
Skin	HMCB	11.8
Skin	HS294T	10.6
Skin	HS600T	11.2
Skin	HS688AT	11
Skin	HS695T	10.1
Skin	HS839T	11.1
Skin	HS852T	10
Skin	HS895T	11.1
Skin	HS934T	10.7
Skin	HS936T	10.6
Skin	HS939T	10.7
Skin	HS940T	10.5
Skin	HS944T	9.8
Skin	HT144	10.9
Skin	IGR1	10.6
Skin	IGR37	10.6
Skin	IGR39	10.8
Skin	IPC298	10.1
Skin	K029AX	10.5
Skin	LOXIMVI	10.7
Skin	MALME3M	11.1
Skin	MDAMB435S	9.7
Skin	MELHO	10.3
Skin	MELJUSO	10.1
Skin	MEWO	11
Skin	RPMI7951	10
Skin	RVH421	10.5
Skin	SH4	10.5
Skin	SKMEL1	11.2
Skin	SKMEL24	10.8
Skin	SKMEL28	10.1
Skin	SKMEL2	10.6
Skin	SKMEL30	10.8
Skin	SKMEL31	11
Skin	SKMEL3	10.4
Skin	SKMEL5	10.5
Skin	UACC257	10.9
Skin	UACC62	9.9
Skin	WM115	11
Skin	WM1799	11.1
Skin	WM2664	10.9
Skin	WM793	10.4
Skin	WM88	10.5
Skin	WM983B	10.5
Small intestine	HUTU80	11.5
Soft tissue	A204	11
Soft tissue	G401	10.9
Soft tissue	G402	11.3
Soft tissue	GCT	9.5
Soft tissue	HS729	11.1
Soft tissue	HT1080	10.6
Soft tissue	KYM1	11.1
Soft tissue	MESSA	10.9
Soft tissue	RD	11.1
Soft tissue	RH30	11
Soft tissue	RH41	11.6
Soft tissue	RKN	10.6
Soft tissue	S117	10.5
Soft tissue	SJRH30	11.1
Soft tissue	SKLMS1	10.1
Soft tissue	SKUT1	11.2
Soft tissue	TE125T	11
Soft tissue	TE159T	11.2
Soft tissue	TE441T	11.4
Soft tissue	TE617T	10.8
Stomach	2313287	10.4
Stomach	AGS	11
Stomach	AZ521	11.2
Stomach	ECC10	11.8
Stomach	ECC12	10.9
Stomach	FU97	10.2
Stomach	GCIY	11.5
Stomach	GSS	11.6
Stomach	GSU	10.9
Stomach	HGC27	11
Stomach	HS746T	9.9
Stomach	HUG1N	10
Stomach	IM95	10.1
Stomach	KATOIII	10.8
Stomach	KE39	11
Stomach	LMSU	10.5
Stomach	MKN1	11.3
Stomach	MKN45	11.1
Stomach	MKN74	9
Stomach	MKN7	11.1
Stomach	NCCSTCK140	11.1
Stomach	NCIN87	12.1
Stomach	NUGC2	10.7
Stomach	NUGC3	10.2
Stomach	NUGC4	11.9
Stomach	OCUM1	10.9
Stomach	RERFGC1B	11.2
Stomach	SH10TC	10.7
Stomach	SNU16	10.8
Stomach	SNU1	11.4
Stomach	SNU216	12.4
Stomach	SNU520	10.4
Stomach	SNU5	11.3
Stomach	SNU601	10.5
Stomach	SNU620	11
Stomach	SNU668	10.9
Stomach	SNU719	9.6
Stomach	TGBC11TKB	10.5
Thyroid	8305C	10.4
Thyroid	8505C	10.7
Thyroid	BCPAP	11.1
Thyroid	BHT101	10.2
Thyroid	CAL62	10.2
Thyroid	CGTHW1	11
Thyroid	FTC133	9.8
Thyroid	FTC238	11.2
Thyroid	ML1	11
Thyroid	SW579	10.6
Thyroid	TT2609C02	11.2
Thyroid	TT	11.1
Upper aerodigestive tract	BHY	9.6
Upper aerodigestive tract	BICR16	8.8
Upper aerodigestive tract	BICR18	9.6
Upper aerodigestive tract	BICR22	10.7
Upper aerodigestive tract	BICR31	12.4
Upper aerodigestive tract	BICR56	10.4
Upper aerodigestive tract	BICR6	11
Upper aerodigestive tract	CAL27	10
Upper aerodigestive tract	CAL33	9.9
Upper aerodigestive tract	DETROIT562	9.8
Upper aerodigestive tract	FADU	10.9
Upper aerodigestive tract	HS840T	10.8
Upper aerodigestive tract	HSC2	10.4
Upper aerodigestive tract	HSC3	10.6
Upper aerodigestive tract	HSC4	11
Upper aerodigestive tract	PECAPJ15	10.1
Upper aerodigestive tract	PECAPJ34CLONEC12	10.6
Upper aerodigestive tract	PECAPJ41CLONED2	10.8
Upper aerodigestive tract	PECAPJ49	10.5
Upper aerodigestive tract	SCC15	10
Upper aerodigestive tract	SCC25	10.5
Upper aerodigestive tract	SCC4	10.7
Upper aerodigestive tract	SCC9	10.5
Upper aerodigestive tract	SNU1076	11.1
Upper aerodigestive tract	SNU1214	11
Upper aerodigestive tract	SNU46	10.4
Upper aerodigestive tract	SNU899	10.3
Upper aerodigestive tract	YD10B	10.1
Upper aerodigestive tract	YD38	8.7
Upper aerodigestive tract	YD8	10.5
Urinary tract	5637	11.6
Urinary tract	639V	10.6
Urinary tract	647V	10.8
Urinary tract	BC3C	10.8
Urinary tract	BFTC905	11.1
Urinary tract	CAL29	10.7
Urinary tract	HS172T	11.1
Urinary tract	HT1197	11
Urinary tract	HT1376	11.1
Urinary tract	J82	10.5
Urinary tract	JMSU1	10.2
Urinary tract	KMBC2	11
Urinary tract	KU1919	10.6
Urinary tract	RT11284	11.3
Urinary tract	RT112	11.1
Urinary tract	RT4	11.2
Urinary tract	SCABER	9.1
Urinary tract	SW1710	12.1
Urinary tract	SW780	11
Urinary tract	T24	10.5
Urinary tract	TCCSUP	10
Urinary tract	UMUC1	10.7
Urinary tract	UMUC3	11
Urinary tract	VMCUB1	10.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	33.9
Adrenal gland	27.2
Appendix	52.9
Bone marrow	30.6
Breast	29
Cerebral cortex	35.5
Cervix, uterine	33.7
Colon	31.8
Duodenum	44.4
Endometrium	72.9
Epididymis	22.8
Esophagus	44.5
Fallopian tube	41
Gallbladder	58.5
Heart muscle	17.3
Kidney	24.2
Liver	12.6
Lung	44.6
Lymph node	54
Ovary	52.6
Pancreas	6.3
Parathyroid gland	24
Placenta	50.6
Prostate	34.4
Rectum	26.4
Salivary gland	10.6
Seminal vesicle	36.6
Skeletal muscle	14.6
Skin	26.1
Small intestine	39.7
Smooth muscle	51.8
Spleen	42.7
Stomach	24.9
Testis	56.8
Thyroid gland	56.8
Tonsil	33.8
Urinary bladder	47.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27495308	overexpression	Breast Carcinoma	Expression data analysis of a large cohort of human breast tumors revealed that high expression of SMARCE1 or PTK2 is associated with poor prognosis and tumor relapse, and PTK2 expression is positively correlated with SMARCE1 expression in basal-like and luminal B subtypes of breast tumors.
25143307	loss of expression (mutation)	Spinal Multifocal Clear Cell Meningioma; Cranial Clear Cell Meningioma	Copy number analysis identified a large deletion of the 5' end of SMARCE1 in two unrelated probands with spinal clear cell meningiomas. In addition, we found loss of SMARCE1 protein in three of 10 paraffin-embedded cranial clear cell meningiomas.
24880093	overexpression	Ovarian Neoplasm	Among other genes, we discovered that TTF1, a regulator of ribosomal RNA gene expression, and SMARCE1, a factor associated with chromatin remodeling were overexpressed in first stage CD8+ ovarian tumors.
23493350	overexpression	Prostate Carcinoma	Immunohistochemical quantitation of primary human specimens revealed that BAF57 was significantly and aberrantly elevated as a function of tumor grade.
18559499	aberrant expression	Prostate Carcinoma	Although selected SWI/SNF subunit expression is reduced in prostate cancer, we show that BAF57 is retained in human disease and is elevated in a subset of tumors.

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.568	6.77e-36	7.2	54.7	38.1	Gain
BRCA	Breast invasive carcinoma	1075	0.786	2.3e-226	30.2	45.5	24.3	Neutral
CESC	Cervical and endocervical cancers	292	0.575	4.5e-27	12.3	71.6	16.1	Neutral
COAD	Colon adenocarcinoma	449	0.596	1.35e-44	11.4	64.8	23.8	Neutral
ESCA	Esophageal carcinoma	183	0.873	1.86e-58	10.4	51.4	38.3	Gain
GBM	Glioblastoma multiforme	147	0.541	1.53e-12	12.9	77.6	9.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.632	1.42e-58	7.2	75.9	16.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.462	3.52e-29	5.7	88.6	5.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.562	2.35e-25	0.3	34	65.6	Gain
LAML	Acute Myeloid Leukemia	166	0.579	2.91e-16	4.8	92.8	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.285	4.62e-11	3.9	92	4.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.613	6.91e-39	10.4	63.7	25.8	Neutral
LUAD	Lung adenocarcinoma	512	0.642	9.08e-61	8.4	49.6	42	Gain
LUSC	Lung squamous cell carcinoma	498	0.623	6.54e-55	22.3	44.2	33.5	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.713	7.01e-48	78	14.7	7.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.609	2.3e-19	10.7	75.1	14.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.745	6.02e-30	21.6	75.3	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.323	2.37e-13	9.6	88.6	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.376	7.04e-07	13.4	61.6	25	Neutral
SARC	Sarcoma	255	0.68	6.6e-36	25.9	56.9	17.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.529	7.81e-28	18.8	62.9	18.3	Neutral
STAD	Stomach adenocarcinoma	413	0.845	1.32e-113	11.6	61.3	27.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.554	1.88e-13	10.7	52.7	36.7	Gain
THCA	Thyroid carcinoma	497	0.238	7.51e-08	0.2	95.6	4.2	Neutral
THYM	Thymoma	119	0.435	7.45e-07	5	87.4	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.602	3.08e-54	20.5	72.4	7.1	Neutral

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.224	3.44e-06	17	408	0.001	0.0323	NS/NA
BRCA	Breast invasive carcinoma	-0.322	0	83	785	-0.001	0.786	NS/NA
CESC	Cervical and endocervical cancers	-0.334	2.25e-09	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.228	4.47e-05	19	297	0	0.088	NS/NA
ESCA	Esophageal carcinoma	-0.353	5.2e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.221	0.0764	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.128	0.00294	20	522	0.001	0.536	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.186	0.000545	24	319	0.003	4.81e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.234	4.85e-05	23	275	0.001	3.57e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.133	0.0842	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.121	0.00516	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.098	0.047	41	373	0.002	0.00137	NS/NA
LUAD	Lung adenocarcinoma	-0.268	3.08e-09	21	456	0.042	0.0131	NS/NA
LUSC	Lung squamous cell carcinoma	-0.296	5.18e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.933	0.00075	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.28	0.000132	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.453	1.07e-10	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.139	0.00126	35	498	0.002	0.243	NS/NA
READ	Rectum adenocarcinoma	-0.331	0.000759	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.356	3.63e-09	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.259	1.21e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.332	6.5e-11	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.417	8.52e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.125	0.00313	50	509	0	0.711	NS/NA
THYM	Thymoma	-0.156	0.0861	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.214	3.46e-06	34	431	-0.002	0.836	NS/NA

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	2	Medium
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	2	Medium
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.136	NS	24476821
BRCA	Breast invasive carcinoma	521	1.34e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.295	NS	22810696
GBM	Glioblastoma multiforme	157	0.000429	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0161	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.312	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.0899	NS	26824661
LUAD	Lung adenocarcinoma	230	0.00198	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.6e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.72e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	4.92e-08	Significant	26544944
READ	Rectum adenocarcinoma	67	0.497	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.496	NS	26091043
STAD	Stomach adenocarcinoma	277	0.168	NS	25079317
THCA	Thyroid carcinoma	391	0.00318	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000152	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.858	0.461	NS
BRCA	Breast invasive carcinoma	1079	0.878	0.57	NS
CESC	Cervical and endocervical cancers	291	0.873	0.68	NS
COAD	Colon adenocarcinoma	439	0.822	0.476	NS
ESCA	Esophageal carcinoma	184	1.104	0.774	NS
GBM	Glioblastoma multiforme	158	0.758	0.274	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.911	0.644	NS
KIRC	Kidney renal clear cell carcinoma	531	1.332	0.177	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.159	0.0516	NS
LAML	Acute Myeloid Leukemia	149	0.881	0.663	NS
LGG	Brain Lower Grade Glioma	511	1.757	0.0239	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.251	0.343	NS
LUAD	Lung adenocarcinoma	502	0.971	0.888	NS
LUSC	Lung squamous cell carcinoma	494	0.815	0.295	NS
OV	Ovarian serous cystadenocarcinoma	303	1.081	0.718	NS
PAAD	Pancreatic adenocarcinoma	177	0.821	0.496	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.343	0.362	NS
PRAD	Prostate adenocarcinoma	497	0.711	0.633	NS
READ	Rectum adenocarcinoma	159	1.319	0.652	NS
SARC	Sarcoma	259	1.481	0.148	NS
SKCM	Skin Cutaneous Melanoma	459	0.958	0.824	NS
STAD	Stomach adenocarcinoma	388	1.243	0.345	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.283	NS
THCA	Thyroid carcinoma	500	0.51	0.325	NS
THYM	Thymoma	119	0	0.0218	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.487	0.0202	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.066	0.185	NS
BRCA	Breast invasive carcinoma	1071	-0.048	0.116	NS
CESC	Cervical and endocervical cancers	167	-0.162	0.0364	Lower
COAD	Colon adenocarcinoma	445	0.054	0.255	NS
ESCA	Esophageal carcinoma	162	0.034	0.67	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.03	0.529	NS
KIRC	Kidney renal clear cell carcinoma	531	0.053	0.226	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.079	0.203	NS
LIHC	Liver hepatocellular carcinoma	347	0.079	0.142	NS
LUAD	Lung adenocarcinoma	507	0.042	0.35	NS
LUSC	Lung squamous cell carcinoma	497	0.022	0.632	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.049	0.395	NS
PAAD	Pancreatic adenocarcinoma	176	-0.124	0.102	NS
READ	Rectum adenocarcinoma	156	0.172	0.0322	Higher
SKCM	Skin Cutaneous Melanoma	410	-0.066	0.182	NS
STAD	Stomach adenocarcinoma	392	0.041	0.417	NS
TGCT	Testicular Germ Cell Tumors	81	0.211	0.0591	NS
THCA	Thyroid carcinoma	499	-0.024	0.596	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.061	0.175	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.139	0.0218	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.114	0.0112	Higher
KIRC	Kidney renal clear cell carcinoma	525	0	0.999	NS
LGG	Brain Lower Grade Glioma	514	0.283	6.14e-11	Higher
LIHC	Liver hepatocellular carcinoma	366	0.18	0.000532	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.096	0.1	NS
PAAD	Pancreatic adenocarcinoma	176	-0.249	0.000861	Lower
STAD	Stomach adenocarcinoma	406	-0.069	0.164	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.056	0.2	NS

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMARCE1.

Summary
Symbol	SMARCE1
Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases	BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Location	17q21.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27495308	Breast Carcinoma	partner	PTK2	positive correlation	Expression data analysis of a large cohort of human breast tumors revealed that high expression of SMARCE1 or PTK2 is associated with poor prognosis and tumor relapse, and PTK2 expression is positively correlated with SMARCE1 expression in basal-like and luminal B subtypes of breast tumors.
24880093	Ovarian Neoplasm	downstream	IL8; MIP1b; RANTES	positive regulation	Interestingly, forced overexpression of SMARCE1 in SKOV3 ovarian cancer cells resulted in secretion of IL8, MIP1b and RANTES chemokines in the supernatant and triggered chemotaxis of CD8+ lymphocytes in a cell culture assay.
21465167	Breast Carcinoma	partner	ETS2	interaction	In addition, the mutations in BAF57 affect its functional interaction with the androgen receptor and ETS2, two transcription factors that play an important role in breast cell biology.
16135788	Breast Carcinoma	downstream	CYLD	positive regulation	Furthermore, microarray analysis revealed that BAF57-mediated cell death was associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which was found to be a direct target of BAF57 as determined by chromatin immunoprecipitation analysis.