CR2Cancer

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00856 SET domain
PF01753 MYND finger

Function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3K4, H3K36	H3K4me, H3K36me2	18065756

> Gene Ontology [ TOP ]
Biological Process	GO:0006479 protein methylation GO:0007507 heart development GO:0008213 protein alkylation GO:0010452 histone H3-K36 methylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018026 peptidyl-lysine monomethylation GO:0018027 peptidyl-lysine dimethylation GO:0018205 peptidyl-lysine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0032259 methylation GO:0034968 histone lysine methylation GO:0042770 signal transduction in response to DNA damage GO:0043414 macromolecule methylation GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator GO:2001020 regulation of response to DNA damage stimulus
Molecular Function	GO:0000993 RNA polymerase II core binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0002039 p53 binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0043175 RNA polymerase core enzyme binding GO:0046975 histone methyltransferase activity (H3-K36 specific) GO:0070063 RNA polymerase binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214841: PKMTs methylate histone lysines R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804760: Regulation of TP53 Activity through Methylation R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5379612	c.361G>A	p.E121K	Substitution - Missense	Skin
COSM346574	c.796G>A	p.E266K	Substitution - Missense	Lung
COSM3689341	c.181G>T	p.G61*	Substitution - Nonsense	Large_intestine
COSM3705476	c.1098C>A	p.I366I	Substitution - coding silent	Liver
COSM4519744	c.1026G>A	p.M342I	Substitution - Missense	Skin
COSM903690	c.493G>A	p.G165R	Substitution - Missense	Endometrium
COSM2151411	c.1032C>A	p.Y344*	Substitution - Nonsense	Central_nervous_system
COSM5427312	c.423A>G	p.L141L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4728608	c.688A>T	p.I230F	Substitution - Missense	Large_intestine
COSM5031429	c.115T>A	p.Y39N	Substitution - Missense	Pancreas
COSM4493290	c.412C>T	p.L138L	Substitution - coding silent	Skin
COSM5604960	c.407C>T	p.S136L	Substitution - Missense	Skin
COSM4949851	c.317T>C	p.V106A	Substitution - Missense	Liver
COSM1491965	c.1113-2A>T	p.?	Unknown	Kidney
COSM342334	c.997G>A	p.E333K	Substitution - Missense	Lung
COSM903694	c.849C>T	p.S283S	Substitution - coding silent	Endometrium
COSM1601636	c.1143G>A	p.V381V	Substitution - coding silent	Liver
COSM1930656	c.114C>G	p.A38A	Substitution - coding silent	Large_intestine
COSM1185729	c.506A>C	p.N169T	Substitution - Missense	Lung
COSM1338726	c.65delG	p.A23fs*84	Deletion - Frameshift	Large_intestine
COSM3943447	c.265G>T	p.E89*	Substitution - Nonsense	Ovary
COSM903692	c.612G>T	p.L204F	Substitution - Missense	Endometrium
COSM1295855	c.354C>A	p.I118I	Substitution - coding silent	Urinary_tract
COSM5786777	c.618T>G	p.N206K	Substitution - Missense	Breast
COSM331168	c.850G>T	p.D284Y	Substitution - Missense	Lung
COSM1930657	c.131C>A	p.T44K	Substitution - Missense	Large_intestine
COSM1226915	c.380A>C	p.K127T	Substitution - Missense	Large_intestine
COSM5427312	c.423A>G	p.L141L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3705476	c.1098C>A	p.I366I	Substitution - coding silent	Liver
COSM678672	c.144G>T	p.R48R	Substitution - coding silent	Lung
COSM5025509	c.409+1G>A	p.?	Unknown	Breast
COSM4728610	c.1257T>C	p.D419D	Substitution - coding silent	Large_intestine
COSM1601635	c.300G>T	p.W100C	Substitution - Missense	Liver
COSM5429812	c.1033C>G	p.Q345E	Substitution - Missense	Oesophagus
COSM903696	c.957G>A	p.E319E	Substitution - coding silent	Endometrium
COSM5969142	c.1147T>C	p.S383P	Substitution - Missense	Upper_aerodigestive_tract
COSM1473385	c.559G>A	p.E187K	Substitution - Missense	Breast
COSM5895532	c.305C>T	p.P102L	Substitution - Missense	Skin
COSM4949851	c.317T>C	p.V106A	Substitution - Missense	Liver
COSM463917	c.1249G>A	p.G417S	Substitution - Missense	Kidney
COSM903695	c.895C>T	p.R299C	Substitution - Missense	Endometrium
COSM5901091	c.304C>T	p.P102S	Substitution - Missense	Skin
COSM903689	c.378A>T	p.E126D	Substitution - Missense	Endometrium
COSM4412410	c.277A>G	p.M93V	Substitution - Missense	Oesophagus
COSM1338729	c.916C>T	p.R306W	Substitution - Missense	Large_intestine
COSM903690	c.493G>A	p.G165R	Substitution - Missense	Stomach
COSM5053079	c.256C>T	p.H86Y	Substitution - Missense	Stomach
COSM425270	c.870C>T	p.A290A	Substitution - coding silent	Skin
COSM82381	c.408A>G	p.S136S	Substitution - coding silent	Ovary
COSM5379611	c.251C>T	p.P84L	Substitution - Missense	Skin
COSM2151411	c.1032C>A	p.Y344*	Substitution - Nonsense	Central_nervous_system
COSM678670	c.656G>T	p.G219V	Substitution - Missense	Lung
COSM1601636	c.1143G>A	p.V381V	Substitution - coding silent	Liver
COSM4963450	c.415G>A	p.D139N	Substitution - Missense	Pancreas
COSM1185728	c.503A>T	p.D168V	Substitution - Missense	Lung
COSM4804004	c.978G>T	p.E326D	Substitution - Missense	Liver
COSM5506768	c.1227T>G	p.I409M	Substitution - Missense	Biliary_tract
COSM4746294	c.901G>A	p.V301I	Substitution - Missense	Central_nervous_system
COSM4728609	c.839G>A	p.R280Q	Substitution - Missense	Large_intestine
COSM1744426	c.337C>T	p.L113L	Substitution - coding silent	Biliary_tract
COSM3483230	c.354C>T	p.I118I	Substitution - coding silent	Skin
COSM5610664	c.804C>T	p.T268T	Substitution - coding silent	Skin
COSM126338	c.430G>A	p.E144K	Substitution - Missense	Upper_aerodigestive_tract
COSM4904460	c.730C>T	p.L244L	Substitution - coding silent	Skin
COSM425269	c.381A>G	p.K127K	Substitution - coding silent	Breast
COSM903693	c.699_700insGAG	p.E235_V236insE	Insertion - In frame	Endometrium
COSM4433749	c.903C>A	p.V301V	Substitution - coding silent	Oesophagus
COSM5969141	c.156C>T	p.C52C	Substitution - coding silent	Upper_aerodigestive_tract
COSM1295856	c.955G>A	p.E319K	Substitution - Missense	Urinary_tract
COSM3483231	c.577C>T	p.H193Y	Substitution - Missense	Skin
COSM678671	c.197G>T	p.G66V	Substitution - Missense	Lung
COSM3483229	c.120C>T	p.A40A	Substitution - coding silent	Skin
COSM1601635	c.300G>T	p.W100C	Substitution - Missense	Liver
COSM1930657	c.131C>A	p.T44K	Substitution - Missense	Large_intestine
COSM1338727	c.306C>A	p.P102P	Substitution - coding silent	Large_intestine
COSM5014181	c.1297C>G	p.H433D	Substitution - Missense	Kidney
COSM4919125	c.663G>T	p.L221L	Substitution - coding silent	Liver
COSM3360636	c.266A>C	p.E89A	Substitution - Missense	Kidney
COSM903695	c.895C>T	p.R299C	Substitution - Missense	Large_intestine
COSM403929	c.297C>A	p.N99K	Substitution - Missense	Lung
COSM4804004	c.978G>T	p.E326D	Substitution - Missense	Liver
COSM903691	c.516C>T	p.L172L	Substitution - coding silent	Endometrium
COSM1338728	c.591G>A	p.A197A	Substitution - coding silent	Large_intestine
COSM5016920	c.670G>T	p.V224F	Substitution - Missense	Kidney
COSM903688	c.203G>A	p.C68Y	Substitution - Missense	Endometrium
COSM3483232	c.626G>A	p.C209Y	Substitution - Missense	Skin
COSM425270	c.870C>T	p.A290A	Substitution - coding silent	Breast
COSM4904542	c.498C>T	p.F166F	Substitution - coding silent	Skin
COSM4963450	c.415G>A	p.D139N	Substitution - Missense	Pancreas
COSM1601636	c.1143G>A	p.V381V	Substitution - coding silent	Liver
COSM3803839	c.766G>A	p.D256N	Substitution - Missense	Breast
COSM903697	c.963C>T	p.C321C	Substitution - coding silent	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for SMYD2.

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.27	5.425	1.082	6.18e-11	Over
BRCA	Breast invasive carcinoma	112	1100	5.006	5.226	0.239	0.00159	NS
CESC	Cervical and endocervical cancers	3	306	3.887	5.493	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.4	5.257	0.874	4.15e-26	Over
ESCA	Esophageal carcinoma	11	185	4.793	4.796	0.067	0.792	NS
GBM	Glioblastoma multiforme	5	166	5.845	5.047	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.605	5.061	0.494	1.35e-08	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.044	5.934	0.909	4.38e-49	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	4.786	5.656	0.839	9.5e-16	Over
LAML	Acute Myeloid Leukemia	0	173	NA	4.845	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.688	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.469	5.255	0.776	6.84e-08	Over
LUAD	Lung adenocarcinoma	59	517	5.248	5.253	-0.011	0.898	NS
LUSC	Lung squamous cell carcinoma	51	501	5.199	5.485	0.274	0.000565	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.038	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.993	4.783	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.116	5.533	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.258	4.868	0.638	4.09e-11	Over
READ	Rectum adenocarcinoma	10	167	4.462	5.292	0.784	3.58e-06	Over
SARC	Sarcoma	2	263	4.715	4.284	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.362	5.154	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.092	4.642	0.438	4.95e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.999	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.236	4.879	-0.331	1.21e-11	NS
THYM	Thymoma	2	120	5.106	5.591	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.434	5.477	0.965	8.31e-12	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.4
Autonomic ganglia	CHP212	10.6
Autonomic ganglia	IMR32	10.2
Autonomic ganglia	KELLY	11.4
Autonomic ganglia	KPNRTBM1	10.2
Autonomic ganglia	KPNSI9S	11.2
Autonomic ganglia	KPNYN	10.4
Autonomic ganglia	MHHNB11	10.5
Autonomic ganglia	NB1	9.8
Autonomic ganglia	NH6	10.1
Autonomic ganglia	SHSY5Y	10.3
Autonomic ganglia	SIMA	9.3
Autonomic ganglia	SKNAS	11.8
Autonomic ganglia	SKNBE2	11.3
Autonomic ganglia	SKNDZ	10.7
Autonomic ganglia	SKNFI	8.6
Autonomic ganglia	SKNSH	10.2
Biliary tract	HUCCT1	11.3
Biliary tract	HUH28	10.5
Biliary tract	SNU1079	11
Biliary tract	SNU1196	9.3
Biliary tract	SNU245	10
Biliary tract	SNU308	10.7
Biliary tract	SNU478	9.3
Bone	143B	10.6
Bone	A673	9.4
Bone	CADOES1	9.1
Bone	CAL78	10.1
Bone	G292CLONEA141B1	10.6
Bone	HOS	10.5
Bone	HS706T	10.3
Bone	HS737T	10.4
Bone	HS819T	10.4
Bone	HS821T	9.5
Bone	HS822T	10.7
Bone	HS863T	10.6
Bone	HS870T	10.8
Bone	HS888T	9.6
Bone	MG63	10.5
Bone	MHHES1	10.6
Bone	OUMS27	9.5
Bone	RDES	10
Bone	SJSA1	10.4
Bone	SKES1	10.1
Bone	SKNMC	10.3
Bone	SW1353	10
Bone	T173	10.3
Bone	TC71	8.8
Bone	U2OS	11.1
Breast	AU565	11.5
Breast	BT20	11.3
Breast	BT474	10.5
Breast	BT483	11
Breast	BT549	9.9
Breast	CAL120	9.6
Breast	CAL148	10.7
Breast	CAL51	9.6
Breast	CAL851	10.9
Breast	CAMA1	11.5
Breast	DU4475	12.9
Breast	EFM192A	10.8
Breast	EFM19	11.7
Breast	EVSAT	10.7
Breast	HCC1143	11.2
Breast	HCC1187	11.6
Breast	HCC1395	9.8
Breast	HCC1419	9.6
Breast	HCC1428	11.1
Breast	HCC1500	10.8
Breast	HCC1569	11.4
Breast	HCC1599	11.4
Breast	HCC1806	11.1
Breast	HCC1937	10
Breast	HCC1954	10.6
Breast	HCC202	11.4
Breast	HCC2157	11.4
Breast	HCC2218	10.4
Breast	HCC38	10
Breast	HCC70	10.8
Breast	HDQP1	10.2
Breast	HMC18	10.4
Breast	HS274T	10.7
Breast	HS281T	10.1
Breast	HS343T	10.1
Breast	HS578T	10.1
Breast	HS606T	10.2
Breast	HS739T	10.4
Breast	HS742T	10.6
Breast	JIMT1	10.7
Breast	KPL1	9.8
Breast	MCF7	9.4
Breast	MDAMB134VI	9.7
Breast	MDAMB157	11.1
Breast	MDAMB175VII	10.7
Breast	MDAMB231	11
Breast	MDAMB361	10.6
Breast	MDAMB415	10.3
Breast	MDAMB436	10.1
Breast	MDAMB453	11
Breast	MDAMB468	11.7
Breast	SKBR3	11.2
Breast	T47D	11.4
Breast	UACC812	10.4
Breast	UACC893	10.3
Breast	YMB1	10.5
Breast	ZR751	11.9
Breast	ZR7530	10.5
Central nervous system	1321N1	10.8
Central nervous system	42MGBA	10.4
Central nervous system	8MGBA	10.5
Central nervous system	A172	10.3
Central nervous system	AM38	9.5
Central nervous system	BECKER	10.3
Central nervous system	CAS1	9.3
Central nervous system	CCFSTTG1	10.3
Central nervous system	D283MED	10.6
Central nervous system	D341MED	9.5
Central nervous system	DAOY	9.6
Central nervous system	DBTRG05MG	9.8
Central nervous system	DKMG	9.8
Central nervous system	GAMG	9.7
Central nervous system	GB1	10.5
Central nervous system	GI1	10.9
Central nervous system	GMS10	10.1
Central nervous system	GOS3	10
Central nervous system	H4	10.2
Central nervous system	HS683	10.2
Central nervous system	KALS1	10.5
Central nervous system	KG1C	9.6
Central nervous system	KNS42	8.9
Central nervous system	KNS60	10.3
Central nervous system	KNS81	10.1
Central nervous system	KS1	10
Central nervous system	LN18	10
Central nervous system	LN229	11.1
Central nervous system	M059K	10.6
Central nervous system	MOGGCCM	10.3
Central nervous system	MOGGUVW	9.8
Central nervous system	NMCG1	9.9
Central nervous system	ONS76	10.5
Central nervous system	SF126	10.4
Central nervous system	SF295	9.6
Central nervous system	SNB19	11.2
Central nervous system	SNU1105	10.4
Central nervous system	SNU201	9.2
Central nervous system	SNU466	10.3
Central nervous system	SNU489	9.6
Central nervous system	SNU626	9.2
Central nervous system	SNU738	10.3
Central nervous system	SW1088	10.1
Central nervous system	SW1783	10.2
Central nervous system	T98G	10.1
Central nervous system	TM31	9.5
Central nervous system	U118MG	9
Central nervous system	U138MG	10.4
Central nervous system	U251MG	10.8
Central nervous system	U87MG	10.5
Central nervous system	YH13	10.2
Central nervous system	YKG1	10
Endometrium	AN3CA	9.6
Endometrium	COLO684	11.3
Endometrium	EFE184	10.8
Endometrium	EN	10
Endometrium	ESS1	10.3
Endometrium	HEC108	10
Endometrium	HEC151	10.2
Endometrium	HEC1A	11
Endometrium	HEC1B	10.6
Endometrium	HEC251	9.3
Endometrium	HEC265	10.8
Endometrium	HEC50B	11.2
Endometrium	HEC59	8.6
Endometrium	HEC6	10.9
Endometrium	ISHIKAWAHERAKLIO02ER	9.8
Endometrium	JHUEM1	8.9
Endometrium	JHUEM2	11.1
Endometrium	JHUEM3	12
Endometrium	KLE	11.1
Endometrium	MFE280	10.6
Endometrium	MFE296	9.8
Endometrium	MFE319	10
Endometrium	RL952	11.6
Endometrium	SNGM	10.2
Endometrium	SNU1077	11.4
Endometrium	SNU685	10.6
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	11.4
Haematopoietic and lymphoid	A3KAW	10.4
Haematopoietic and lymphoid	A4FUK	9.3
Haematopoietic and lymphoid	ALLSIL	10.3
Haematopoietic and lymphoid	AML193	10.4
Haematopoietic and lymphoid	AMO1	9
Haematopoietic and lymphoid	BCP1	10.2
Haematopoietic and lymphoid	BDCM	10.4
Haematopoietic and lymphoid	BL41	10
Haematopoietic and lymphoid	BL70	10.5
Haematopoietic and lymphoid	BV173	10.1
Haematopoietic and lymphoid	CA46	9.6
Haematopoietic and lymphoid	CI1	10.1
Haematopoietic and lymphoid	CMK115	9.2
Haematopoietic and lymphoid	CMK86	10.5
Haematopoietic and lymphoid	CMK	9.4
Haematopoietic and lymphoid	CMLT1	10.5
Haematopoietic and lymphoid	COLO775	10.3
Haematopoietic and lymphoid	DAUDI	9.9
Haematopoietic and lymphoid	DB	10.1
Haematopoietic and lymphoid	DEL	11.3
Haematopoietic and lymphoid	DND41	10.5
Haematopoietic and lymphoid	DOHH2	10
Haematopoietic and lymphoid	EB1	9.5
Haematopoietic and lymphoid	EB2	9.8
Haematopoietic and lymphoid	EHEB	9.5
Haematopoietic and lymphoid	EJM	9
Haematopoietic and lymphoid	EM2	9.6
Haematopoietic and lymphoid	EOL1	8.8
Haematopoietic and lymphoid	F36P	9.4
Haematopoietic and lymphoid	GA10	10.3
Haematopoietic and lymphoid	GDM1	7.6
Haematopoietic and lymphoid	GRANTA519	9.7
Haematopoietic and lymphoid	HDLM2	9.4
Haematopoietic and lymphoid	HDMYZ	9.1
Haematopoietic and lymphoid	HEL9217	8.8
Haematopoietic and lymphoid	HEL	8.3
Haematopoietic and lymphoid	HH	10.4
Haematopoietic and lymphoid	HL60	9.5
Haematopoietic and lymphoid	HPBALL	10.3
Haematopoietic and lymphoid	HS604T	10.1
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	10.9
Haematopoietic and lymphoid	HS751T	9.8
Haematopoietic and lymphoid	HT	10.3
Haematopoietic and lymphoid	HTK	10.7
Haematopoietic and lymphoid	HUNS1	10.2
Haematopoietic and lymphoid	HUT102	8.4
Haematopoietic and lymphoid	HUT78	10.4
Haematopoietic and lymphoid	JEKO1	9.5
Haematopoietic and lymphoid	JK1	9.5
Haematopoietic and lymphoid	JM1	10.8
Haematopoietic and lymphoid	JURKAT	10.2
Haematopoietic and lymphoid	JURLMK1	9.7
Haematopoietic and lymphoid	JVM2	8.8
Haematopoietic and lymphoid	JVM3	8.8
Haematopoietic and lymphoid	K562	10.3
Haematopoietic and lymphoid	KARPAS299	11.5
Haematopoietic and lymphoid	KARPAS422	9.1
Haematopoietic and lymphoid	KARPAS620	9.4
Haematopoietic and lymphoid	KASUMI1	9.9
Haematopoietic and lymphoid	KASUMI2	12
Haematopoietic and lymphoid	KASUMI6	8.6
Haematopoietic and lymphoid	KCL22	10.3
Haematopoietic and lymphoid	KE37	11.8
Haematopoietic and lymphoid	KE97	10.7
Haematopoietic and lymphoid	KG1	9.6
Haematopoietic and lymphoid	KHM1B	9.8
Haematopoietic and lymphoid	KIJK	11.7
Haematopoietic and lymphoid	KMH2	11
Haematopoietic and lymphoid	KMM1	9.8
Haematopoietic and lymphoid	KMS11	11.1
Haematopoietic and lymphoid	KMS12BM	9.5
Haematopoietic and lymphoid	KMS18	10.1
Haematopoietic and lymphoid	KMS20	9.1
Haematopoietic and lymphoid	KMS21BM	10.3
Haematopoietic and lymphoid	KMS26	7.4
Haematopoietic and lymphoid	KMS27	9.4
Haematopoietic and lymphoid	KMS28BM	9.9
Haematopoietic and lymphoid	KMS34	10.2
Haematopoietic and lymphoid	KO52	10.2
Haematopoietic and lymphoid	KOPN8	10.6
Haematopoietic and lymphoid	KU812	10.1
Haematopoietic and lymphoid	KYO1	10.2
Haematopoietic and lymphoid	L1236	10.3
Haematopoietic and lymphoid	L363	9.2
Haematopoietic and lymphoid	L428	9.5
Haematopoietic and lymphoid	L540	10.5
Haematopoietic and lymphoid	LAMA84	9.2
Haematopoietic and lymphoid	LOUCY	12.1
Haematopoietic and lymphoid	LP1	7.7
Haematopoietic and lymphoid	M07E	10.2
Haematopoietic and lymphoid	MC116	10.7
Haematopoietic and lymphoid	ME1	9.4
Haematopoietic and lymphoid	MEC1	9.6
Haematopoietic and lymphoid	MEC2	10
Haematopoietic and lymphoid	MEG01	9.6
Haematopoietic and lymphoid	MHHCALL2	10.8
Haematopoietic and lymphoid	MHHCALL3	11.5
Haematopoietic and lymphoid	MHHCALL4	9.8
Haematopoietic and lymphoid	MINO	10.3
Haematopoietic and lymphoid	MJ	10.2
Haematopoietic and lymphoid	MM1S	10
Haematopoietic and lymphoid	MOLM13	10.2
Haematopoietic and lymphoid	MOLM16	8.4
Haematopoietic and lymphoid	MOLM6	10.3
Haematopoietic and lymphoid	MOLP2	9.3
Haematopoietic and lymphoid	MOLP8	9.5
Haematopoietic and lymphoid	MOLT13	10.6
Haematopoietic and lymphoid	MOLT16	10.4
Haematopoietic and lymphoid	MOLT4	10.4
Haematopoietic and lymphoid	MONOMAC1	9
Haematopoietic and lymphoid	MONOMAC6	9
Haematopoietic and lymphoid	MOTN1	9.5
Haematopoietic and lymphoid	MUTZ5	8.7
Haematopoietic and lymphoid	MV411	9.6
Haematopoietic and lymphoid	NALM19	11.3
Haematopoietic and lymphoid	NALM1	11
Haematopoietic and lymphoid	NALM6	10.2
Haematopoietic and lymphoid	NAMALWA	10.5
Haematopoietic and lymphoid	NB4	10
Haematopoietic and lymphoid	NCIH929	10
Haematopoietic and lymphoid	NCO2	10.2
Haematopoietic and lymphoid	NOMO1	9.1
Haematopoietic and lymphoid	NUDHL1	9.8
Haematopoietic and lymphoid	NUDUL1	10
Haematopoietic and lymphoid	OCIAML2	10.3
Haematopoietic and lymphoid	OCIAML3	10.1
Haematopoietic and lymphoid	OCIAML5	10.6
Haematopoietic and lymphoid	OCILY10	9.5
Haematopoietic and lymphoid	OCILY19	10.8
Haematopoietic and lymphoid	OCILY3	11.9
Haematopoietic and lymphoid	OCIM1	9.4
Haematopoietic and lymphoid	OPM2	8
Haematopoietic and lymphoid	P12ICHIKAWA	10.6
Haematopoietic and lymphoid	P31FUJ	9.7
Haematopoietic and lymphoid	P3HR1	10.2
Haematopoietic and lymphoid	PCM6	10.8
Haematopoietic and lymphoid	PEER	10.6
Haematopoietic and lymphoid	PF382	9.8
Haematopoietic and lymphoid	PFEIFFER	9.2
Haematopoietic and lymphoid	PL21	10.2
Haematopoietic and lymphoid	RAJI	10.4
Haematopoietic and lymphoid	RCHACV	11
Haematopoietic and lymphoid	REC1	9.3
Haematopoietic and lymphoid	REH	9.6
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	8.5
Haematopoietic and lymphoid	RPMI8226	9.5
Haematopoietic and lymphoid	RPMI8402	11.4
Haematopoietic and lymphoid	RS411	10.7
Haematopoietic and lymphoid	SEM	10.4
Haematopoietic and lymphoid	SET2	8.3
Haematopoietic and lymphoid	SIGM5	10.4
Haematopoietic and lymphoid	SKM1	11.3
Haematopoietic and lymphoid	SKMM2	9.6
Haematopoietic and lymphoid	SR786	11.5
Haematopoietic and lymphoid	ST486	10.9
Haematopoietic and lymphoid	SUDHL10	10.2
Haematopoietic and lymphoid	SUDHL1	11.6
Haematopoietic and lymphoid	SUDHL4	9.6
Haematopoietic and lymphoid	SUDHL5	10.3
Haematopoietic and lymphoid	SUDHL6	9.8
Haematopoietic and lymphoid	SUDHL8	9.2
Haematopoietic and lymphoid	SUPB15	11.4
Haematopoietic and lymphoid	SUPHD1	10.9
Haematopoietic and lymphoid	SUPM2	12.6
Haematopoietic and lymphoid	SUPT11	10.9
Haematopoietic and lymphoid	SUPT1	10.1
Haematopoietic and lymphoid	TALL1	11.4
Haematopoietic and lymphoid	TF1	9.7
Haematopoietic and lymphoid	THP1	9.8
Haematopoietic and lymphoid	TO175T	10.9
Haematopoietic and lymphoid	TOLEDO	11.3
Haematopoietic and lymphoid	U266B1	11.4
Haematopoietic and lymphoid	U937	10.1
Haematopoietic and lymphoid	UT7	7
Haematopoietic and lymphoid	WSUDLCL2	8.9
Kidney	769P	11.4
Kidney	786O	10.7
Kidney	A498	10.2
Kidney	A704	11.6
Kidney	ACHN	11.1
Kidney	BFTC909	10
Kidney	CAKI1	11.1
Kidney	CAKI2	11.3
Kidney	CAL54	10
Kidney	KMRC1	11.4
Kidney	KMRC20	9.6
Kidney	KMRC2	11.7
Kidney	KMRC3	12
Kidney	OSRC2	10.4
Kidney	RCC10RGB	11
Kidney	SNU1272	11.4
Kidney	SNU349	11.3
Kidney	TUHR10TKB	11.3
Kidney	TUHR14TKB	10.9
Kidney	TUHR4TKB	10.8
Kidney	VMRCRCW	10.4
Kidney	VMRCRCZ	11.1
Large intestine	C2BBE1	11.7
Large intestine	CCK81	10.7
Large intestine	CL11	10.6
Large intestine	CL14	10.4
Large intestine	CL34	9.7
Large intestine	CL40	10.4
Large intestine	COLO205	11.2
Large intestine	COLO320	9.4
Large intestine	COLO678	8.7
Large intestine	CW2	10
Large intestine	DLD1	10.6
Large intestine	GP2D	10.5
Large intestine	HCC56	10.8
Large intestine	HCT116	9.9
Large intestine	HCT15	10.8
Large intestine	HS675T	9.8
Large intestine	HS698T	10.4
Large intestine	HT115	10.3
Large intestine	HT29	10.4
Large intestine	HT55	10.6
Large intestine	KM12	10.6
Large intestine	LOVO	10.5
Large intestine	LS1034	10.6
Large intestine	LS123	10.5
Large intestine	LS180	10.6
Large intestine	LS411N	9.8
Large intestine	LS513	10.6
Large intestine	MDST8	10
Large intestine	NCIH508	9.3
Large intestine	NCIH716	10.2
Large intestine	NCIH747	10.6
Large intestine	OUMS23	11
Large intestine	RCM1	10
Large intestine	RKO	11
Large intestine	SKCO1	11
Large intestine	SNU1040	10.2
Large intestine	SNU1197	10.3
Large intestine	SNU175	10.3
Large intestine	SNU283	10.1
Large intestine	SNU407	11.1
Large intestine	SNU503	10.5
Large intestine	SNU61	10.3
Large intestine	SNU81	10.2
Large intestine	SNUC1	10.9
Large intestine	SNUC2A	8.4
Large intestine	SNUC4	10.4
Large intestine	SNUC5	10.2
Large intestine	SW1116	9.7
Large intestine	SW1417	10.4
Large intestine	SW1463	10.3
Large intestine	SW403	10.8
Large intestine	SW480	10.7
Large intestine	SW48	10.3
Large intestine	SW620	11.2
Large intestine	SW837	10.5
Large intestine	SW948	10.4
Large intestine	T84	10
Liver	ALEXANDERCELLS	10.5
Liver	C3A	10.5
Liver	HEP3B217	11.4
Liver	HEPG2	10.9
Liver	HLE	9.1
Liver	HLF	10.4
Liver	HUH1	10.8
Liver	HUH6	11.4
Liver	HUH7	10.6
Liver	JHH1	9.1
Liver	JHH2	9.7
Liver	JHH4	10.7
Liver	JHH5	11.2
Liver	JHH6	9.9
Liver	JHH7	10.6
Liver	LI7	9.4
Liver	PLCPRF5	10.5
Liver	SKHEP1	9.8
Liver	SNU182	10.9
Liver	SNU387	10.7
Liver	SNU398	10.2
Liver	SNU423	9.6
Liver	SNU449	11.2
Liver	SNU475	10.4
Liver	SNU761	10.9
Liver	SNU878	10.2
Liver	SNU886	10.1
Lung	A549	10.4
Lung	ABC1	11.3
Lung	BEN	8
Lung	CAL12T	10.3
Lung	CALU1	10.9
Lung	CALU3	10.4
Lung	CALU6	9.9
Lung	CHAGOK1	8.9
Lung	COLO668	10.3
Lung	COLO699	10.3
Lung	CORL105	10.9
Lung	CORL23	9.8
Lung	CORL24	11.1
Lung	CORL279	11.3
Lung	CORL311	10.5
Lung	CORL47	10.7
Lung	CORL51	10.3
Lung	CORL88	10.5
Lung	CORL95	10.4
Lung	CPCN	11.5
Lung	DMS114	10.9
Lung	DMS153	10.9
Lung	DMS273	11.1
Lung	DMS454	9.7
Lung	DMS53	11.3
Lung	DMS79	10
Lung	DV90	11.1
Lung	EBC1	9.9
Lung	EPLC272H	11
Lung	HARA	10.5
Lung	HCC1171	10.4
Lung	HCC1195	9.5
Lung	HCC15	10.3
Lung	HCC2279	9.1
Lung	HCC2935	9.4
Lung	HCC33	10.6
Lung	HCC366	9.9
Lung	HCC4006	10.3
Lung	HCC44	9.9
Lung	HCC78	10.6
Lung	HCC827	10.8
Lung	HCC95	10
Lung	HLC1	10.1
Lung	HLFA	9.6
Lung	HS229T	10.5
Lung	HS618T	9.7
Lung	IALM	10.3
Lung	KNS62	9.9
Lung	LC1F	9.9
Lung	LC1SQSF	10
Lung	LCLC103H	9.5
Lung	LCLC97TM1	9.9
Lung	LK2	12.5
Lung	LOUNH91	10.1
Lung	LU65	10.8
Lung	LU99	11.3
Lung	LUDLU1	10.4
Lung	LXF289	9.9
Lung	MORCPR	11
Lung	NCIH1048	12.2
Lung	NCIH1092	10.5
Lung	NCIH1105	10.3
Lung	NCIH1155	10.2
Lung	NCIH1184	10.2
Lung	NCIH1299	10.1
Lung	NCIH1339	10.9
Lung	NCIH1341	10.8
Lung	NCIH1355	10.8
Lung	NCIH1373	10.7
Lung	NCIH1385	11.2
Lung	NCIH1395	10.6
Lung	NCIH1435	10
Lung	NCIH1436	11.1
Lung	NCIH1437	10.2
Lung	NCIH146	11
Lung	NCIH1563	10.2
Lung	NCIH1568	10.2
Lung	NCIH1573	10.1
Lung	NCIH1581	11
Lung	NCIH1618	10.5
Lung	NCIH1623	10.9
Lung	NCIH1648	9.8
Lung	NCIH1650	11.1
Lung	NCIH1651	10
Lung	NCIH1666	11.6
Lung	NCIH1693	11.7
Lung	NCIH1694	11.3
Lung	NCIH1703	10.9
Lung	NCIH1734	10.5
Lung	NCIH1755	10.8
Lung	NCIH1781	10.6
Lung	NCIH1792	9.9
Lung	NCIH1793	10.8
Lung	NCIH1836	11.6
Lung	NCIH1838	10.3
Lung	NCIH1869	10.5
Lung	NCIH1876	10.5
Lung	NCIH1915	11.2
Lung	NCIH1930	10.8
Lung	NCIH1944	10.7
Lung	NCIH1963	10.4
Lung	NCIH196	10.7
Lung	NCIH1975	10.7
Lung	NCIH2009	10.5
Lung	NCIH2023	10.4
Lung	NCIH2029	11.5
Lung	NCIH2030	10.7
Lung	NCIH2066	10.1
Lung	NCIH2081	11.8
Lung	NCIH2085	11.9
Lung	NCIH2087	10.6
Lung	NCIH209	10
Lung	NCIH2106	11
Lung	NCIH2110	9.9
Lung	NCIH211	12.1
Lung	NCIH2122	10.7
Lung	NCIH2126	10
Lung	NCIH2141	9.4
Lung	NCIH2170	10.6
Lung	NCIH2171	9.9
Lung	NCIH2172	10.5
Lung	NCIH2196	10.6
Lung	NCIH2227	10.4
Lung	NCIH2228	10.7
Lung	NCIH226	9.3
Lung	NCIH2286	10.9
Lung	NCIH2291	10.4
Lung	NCIH2342	10.7
Lung	NCIH2347	11.1
Lung	NCIH23	10.4
Lung	NCIH2405	9.8
Lung	NCIH2444	11.2
Lung	NCIH292	10.3
Lung	NCIH322	11
Lung	NCIH3255	10.3
Lung	NCIH358	10.2
Lung	NCIH441	10.7
Lung	NCIH446	10.5
Lung	NCIH460	10.6
Lung	NCIH510	10.8
Lung	NCIH520	12.5
Lung	NCIH522	10.3
Lung	NCIH524	10.3
Lung	NCIH526	9.1
Lung	NCIH596	10.4
Lung	NCIH647	10.3
Lung	NCIH650	10.2
Lung	NCIH661	10.8
Lung	NCIH69	11.4
Lung	NCIH727	10.7
Lung	NCIH810	8.6
Lung	NCIH82	11.1
Lung	NCIH838	10.7
Lung	NCIH841	10.9
Lung	NCIH854	9.8
Lung	NCIH889	11.5
Lung	PC14	10.5
Lung	RERFLCAD1	10.3
Lung	RERFLCAD2	10.9
Lung	RERFLCAI	10.3
Lung	RERFLCKJ	9.9
Lung	RERFLCMS	10.2
Lung	RERFLCSQ1	9.9
Lung	SBC5	10
Lung	SCLC21H	9.3
Lung	SHP77	11.1
Lung	SKLU1	8.7
Lung	SKMES1	10.6
Lung	SQ1	10.7
Lung	SW1271	10.3
Lung	SW1573	10.4
Lung	SW900	10.5
Lung	VMRCLCD	10.1
Lung	VMRCLCP	10
Oesophagus	COLO680N	10.4
Oesophagus	ECGI10	9.2
Oesophagus	KYSE140	10.9
Oesophagus	KYSE150	11.6
Oesophagus	KYSE180	10.5
Oesophagus	KYSE270	10.8
Oesophagus	KYSE30	9.9
Oesophagus	KYSE410	10.6
Oesophagus	KYSE450	10.4
Oesophagus	KYSE510	10.3
Oesophagus	KYSE520	10.3
Oesophagus	KYSE70	9.5
Oesophagus	OE19	9.7
Oesophagus	OE33	10.4
Oesophagus	TE10	8.8
Oesophagus	TE11	10.4
Oesophagus	TE14	10.2
Oesophagus	TE15	10.6
Oesophagus	TE1	10.4
Oesophagus	TE4	10.1
Oesophagus	TE5	10.9
Oesophagus	TE6	10.7
Oesophagus	TE8	9.9
Oesophagus	TE9	10.5
Oesophagus	TT	10.5
Ovary	59M	10.5
Ovary	A2780	10
Ovary	CAOV3	9.9
Ovary	CAOV4	9.3
Ovary	COLO704	11.2
Ovary	COV318	10.7
Ovary	COV362	9.4
Ovary	COV434	8.5
Ovary	COV504	10
Ovary	COV644	10
Ovary	EFO21	10.4
Ovary	EFO27	9.9
Ovary	ES2	10.4
Ovary	FUOV1	10.5
Ovary	HEYA8	10.9
Ovary	HS571T	10.7
Ovary	IGROV1	11.1
Ovary	JHOC5	10.2
Ovary	JHOM1	9.6
Ovary	JHOM2B	10.1
Ovary	JHOS2	9.9
Ovary	JHOS4	10.7
Ovary	KURAMOCHI	10.4
Ovary	MCAS	9.7
Ovary	NIHOVCAR3	9.7
Ovary	OAW28	9.1
Ovary	OAW42	10.5
Ovary	OC314	10.4
Ovary	OC316	10.2
Ovary	ONCODG1	9.4
Ovary	OV56	10.4
Ovary	OV7	10.5
Ovary	OV90	11.1
Ovary	OVCAR4	9.8
Ovary	OVCAR8	9.4
Ovary	OVISE	10.3
Ovary	OVK18	10.1
Ovary	OVKATE	9.3
Ovary	OVMANA	9.9
Ovary	OVSAHO	9.5
Ovary	OVTOKO	10.5
Ovary	RMGI	8.8
Ovary	RMUGS	11.4
Ovary	SKOV3	10.8
Ovary	SNU119	10.5
Ovary	SNU840	10.9
Ovary	SNU8	10.8
Ovary	TOV112D	9.9
Ovary	TOV21G	10.7
Ovary	TYKNU	10
Pancreas	ASPC1	10.2
Pancreas	BXPC3	9.8
Pancreas	CAPAN1	9.7
Pancreas	CAPAN2	10.7
Pancreas	CFPAC1	10.2
Pancreas	DANG	10.8
Pancreas	HPAC	10.3
Pancreas	HPAFII	9.4
Pancreas	HS766T	9.7
Pancreas	HUPT3	10.4
Pancreas	HUPT4	9.9
Pancreas	KCIMOH1	10.8
Pancreas	KLM1	10.5
Pancreas	KP2	9.8
Pancreas	KP3	9.8
Pancreas	KP4	9.7
Pancreas	L33	10.8
Pancreas	MIAPACA2	10.3
Pancreas	PANC0203	10.5
Pancreas	PANC0213	9.6
Pancreas	PANC0327	10.8
Pancreas	PANC0403	9.9
Pancreas	PANC0504	9.8
Pancreas	PANC0813	10
Pancreas	PANC1005	10.1
Pancreas	PANC1	10.3
Pancreas	PATU8902	10.6
Pancreas	PATU8988S	10.4
Pancreas	PATU8988T	10.9
Pancreas	PK1	10.8
Pancreas	PK45H	10
Pancreas	PK59	9.6
Pancreas	PL45	10.6
Pancreas	PSN1	10.4
Pancreas	QGP1	10
Pancreas	SNU213	10.3
Pancreas	SNU324	10.4
Pancreas	SNU410	10.2
Pancreas	SU8686	10.3
Pancreas	SUIT2	9.8
Pancreas	SW1990	11.3
Pancreas	T3M4	9.7
Pancreas	TCCPAN2	9.7
Pancreas	YAPC	10.3
Pleura	ACCMESO1	9.6
Pleura	DM3	9.7
Pleura	ISTMES1	10.6
Pleura	ISTMES2	10.7
Pleura	JL1	9
Pleura	MPP89	10.7
Pleura	MSTO211H	10.4
Pleura	NCIH2052	10.7
Pleura	NCIH2452	9.9
Pleura	NCIH28	10.9
Prostate	22RV1	9
Prostate	DU145	10.1
Prostate	LNCAPCLONEFGC	7.7
Prostate	MDAPCA2B	5.4
Prostate	NCIH660	11.1
Prostate	PC3	11.5
Prostate	VCAP	9.5
Salivary gland	A253	9.8
Salivary gland	YD15	11
Skin	A101D	10.2
Skin	A2058	10.1
Skin	A375	11.1
Skin	C32	10.6
Skin	CHL1	10.9
Skin	CJM	10.7
Skin	COLO679	9.5
Skin	COLO741	10.3
Skin	COLO783	10.3
Skin	COLO792	10.2
Skin	COLO800	10.5
Skin	COLO818	9.8
Skin	COLO829	10
Skin	COLO849	10.2
Skin	G361	9.5
Skin	GRM	10.5
Skin	HMCB	10.9
Skin	HS294T	9.7
Skin	HS600T	10.8
Skin	HS688AT	10.4
Skin	HS695T	10.6
Skin	HS839T	9.9
Skin	HS852T	10.2
Skin	HS895T	10.5
Skin	HS934T	10.1
Skin	HS936T	9.6
Skin	HS939T	10.6
Skin	HS940T	10.6
Skin	HS944T	10.2
Skin	HT144	10.9
Skin	IGR1	9.4
Skin	IGR37	10.6
Skin	IGR39	9.7
Skin	IPC298	10.5
Skin	K029AX	10.2
Skin	LOXIMVI	11.1
Skin	MALME3M	10
Skin	MDAMB435S	10.4
Skin	MELHO	10.3
Skin	MELJUSO	10.7
Skin	MEWO	10.7
Skin	RPMI7951	10.6
Skin	RVH421	10.9
Skin	SH4	11
Skin	SKMEL1	10
Skin	SKMEL24	10.1
Skin	SKMEL28	10.5
Skin	SKMEL2	10.1
Skin	SKMEL30	11.2
Skin	SKMEL31	10.1
Skin	SKMEL3	10.6
Skin	SKMEL5	10.2
Skin	UACC257	10.9
Skin	UACC62	9.5
Skin	WM115	9.8
Skin	WM1799	10
Skin	WM2664	9.5
Skin	WM793	10
Skin	WM88	11.1
Skin	WM983B	9.6
Small intestine	HUTU80	10.2
Soft tissue	A204	10
Soft tissue	G401	9.8
Soft tissue	G402	10.5
Soft tissue	GCT	10
Soft tissue	HS729	9.7
Soft tissue	HT1080	10
Soft tissue	KYM1	9.9
Soft tissue	MESSA	10.1
Soft tissue	RD	10.1
Soft tissue	RH30	11.4
Soft tissue	RH41	10.1
Soft tissue	RKN	9
Soft tissue	S117	10.6
Soft tissue	SJRH30	10
Soft tissue	SKLMS1	9.8
Soft tissue	SKUT1	10.7
Soft tissue	TE125T	11
Soft tissue	TE159T	9.5
Soft tissue	TE441T	9.3
Soft tissue	TE617T	10.1
Stomach	2313287	9.4
Stomach	AGS	10.6
Stomach	AZ521	10
Stomach	ECC10	11.6
Stomach	ECC12	11.6
Stomach	FU97	10.3
Stomach	GCIY	10.1
Stomach	GSS	11.4
Stomach	GSU	9.7
Stomach	HGC27	11.7
Stomach	HS746T	10.6
Stomach	HUG1N	9.6
Stomach	IM95	10.4
Stomach	KATOIII	9.5
Stomach	KE39	9.9
Stomach	LMSU	10.6
Stomach	MKN1	9.9
Stomach	MKN45	10
Stomach	MKN74	9.6
Stomach	MKN7	10.8
Stomach	NCCSTCK140	10.3
Stomach	NCIN87	10.3
Stomach	NUGC2	11.1
Stomach	NUGC3	11
Stomach	NUGC4	9.6
Stomach	OCUM1	10.5
Stomach	RERFGC1B	10.2
Stomach	SH10TC	10.5
Stomach	SNU16	10.3
Stomach	SNU1	10.4
Stomach	SNU216	10.2
Stomach	SNU520	9.5
Stomach	SNU5	9.8
Stomach	SNU601	10.1
Stomach	SNU620	10.1
Stomach	SNU668	10.8
Stomach	SNU719	10.3
Stomach	TGBC11TKB	10.8
Thyroid	8305C	10.8
Thyroid	8505C	9.7
Thyroid	BCPAP	10.5
Thyroid	BHT101	10.2
Thyroid	CAL62	10.1
Thyroid	CGTHW1	10.7
Thyroid	FTC133	10.3
Thyroid	FTC238	10.2
Thyroid	ML1	9.9
Thyroid	SW579	10.5
Thyroid	TT2609C02	10.3
Thyroid	TT	10.4
Upper aerodigestive tract	BHY	10.1
Upper aerodigestive tract	BICR16	10.9
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.8
Upper aerodigestive tract	BICR31	10.2
Upper aerodigestive tract	BICR56	9
Upper aerodigestive tract	BICR6	10.1
Upper aerodigestive tract	CAL27	10
Upper aerodigestive tract	CAL33	8.8
Upper aerodigestive tract	DETROIT562	10.6
Upper aerodigestive tract	FADU	10.4
Upper aerodigestive tract	HS840T	10
Upper aerodigestive tract	HSC2	10.8
Upper aerodigestive tract	HSC3	11.2
Upper aerodigestive tract	HSC4	10.5
Upper aerodigestive tract	PECAPJ15	9.4
Upper aerodigestive tract	PECAPJ34CLONEC12	10.3
Upper aerodigestive tract	PECAPJ41CLONED2	10.9
Upper aerodigestive tract	PECAPJ49	10.7
Upper aerodigestive tract	SCC15	9.9
Upper aerodigestive tract	SCC25	10.3
Upper aerodigestive tract	SCC4	10.7
Upper aerodigestive tract	SCC9	10.3
Upper aerodigestive tract	SNU1076	9.6
Upper aerodigestive tract	SNU1214	10.5
Upper aerodigestive tract	SNU46	9.7
Upper aerodigestive tract	SNU899	9.7
Upper aerodigestive tract	YD10B	10.4
Upper aerodigestive tract	YD38	10.2
Upper aerodigestive tract	YD8	10
Urinary tract	5637	11
Urinary tract	639V	10.1
Urinary tract	647V	10.7
Urinary tract	BC3C	9.7
Urinary tract	BFTC905	10.3
Urinary tract	CAL29	10.2
Urinary tract	HS172T	9.9
Urinary tract	HT1197	12
Urinary tract	HT1376	11.5
Urinary tract	J82	10.8
Urinary tract	JMSU1	10.7
Urinary tract	KMBC2	9.7
Urinary tract	KU1919	10.4
Urinary tract	RT11284	10.1
Urinary tract	RT112	10.7
Urinary tract	RT4	10.7
Urinary tract	SCABER	11
Urinary tract	SW1710	11
Urinary tract	SW780	11.4
Urinary tract	T24	10.1
Urinary tract	TCCSUP	10.5
Urinary tract	UMUC1	11.2
Urinary tract	UMUC3	9.8
Urinary tract	VMCUB1	10.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	16.8
Adrenal gland	22
Appendix	14.3
Bone marrow	6.1
Breast	27
Cerebral cortex	41.6
Cervix, uterine	21.1
Colon	14.8
Duodenum	15.4
Endometrium	18.7
Epididymis	18.7
Esophagus	17.8
Fallopian tube	48.7
Gallbladder	17.6
Heart muscle	126.2
Kidney	24.1
Liver	15.3
Lung	30.4
Lymph node	18.3
Ovary	16.6
Pancreas	3.3
Parathyroid gland	13.3
Placenta	46.5
Prostate	21.4
Rectum	19.3
Salivary gland	6.6
Seminal vesicle	11.9
Skeletal muscle	34.9
Skin	14.6
Small intestine	16.4
Smooth muscle	16.9
Spleen	23.5
Stomach	18
Testis	52
Thyroid gland	38.8
Tonsil	15.4
Urinary bladder	19.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26826421	Overexpression	Head and Neck Squamous Cell Carcinoma	Among 197 HPV-unrelated HNSCC cases, overexpression of SMYD2 protein was detected in 75 (60%) of 126 nonmultiple cases and 51 (70%) of 71 multiple cases.
26790435	Overexpression	Chronic Lymphocytic Leukemia	We found that SMYD2 and SMYD3 are overexpressed in CLL patients and, interestingly, patients with residual expression of both genes presented a high WBC count and complex karyotype.
25321194	Overexpression	Gastric Carcinoma	Patients with SMYD2-overexpressing tumours had a worse overall rate of survival than those with non-expressing tumours (P=0.0073, log-rank test) in an intensity and proportion score-dependent manner.
24631370	Overexpression	Acute Lymphocytic Leukemia	The study revealed that SMYD2 expression is altered in ALL BMS and its high expression was correlated with a bad prognosis.
19423649	Overexpression	Oesophagal Squamous Cell Carcinoma	Overexpression of SMYD2 protein was frequently detected in primary tumor samples of ESCC (117/153 cases, 76.5%) as well and significantly correlated with gender, venous invasion, the pT category in the tumor-lymph node-metastases classification and status of recurrence.
20512085	Underexpression	Laryngeal Carcinoma	The coherent low Sp100 expression of both transcriptional and translational levels were confirmed in the malignant tissues compared to the normal mucosa, and the expression was down-regulated among the well-, moderately- and poorly-differentiated cancer cells accordingly.

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.397	1.08e-16	14.9	53.5	31.7	Neutral
BRCA	Breast invasive carcinoma	1075	0.338	3.5e-30	2.8	23.7	73.5	Gain
CESC	Cervical and endocervical cancers	292	0.365	1.24e-10	3.1	46.6	50.3	Gain
COAD	Colon adenocarcinoma	449	0.463	2.99e-25	9.8	68.8	21.4	Neutral
ESCA	Esophageal carcinoma	183	0.58	7.35e-18	9.8	43.2	47	Gain
GBM	Glioblastoma multiforme	147	0.279	0.000627	7.5	76.2	16.3	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.297	5.94e-12	7.2	65.8	27	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.244	1.39e-08	7.6	81.5	10.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.123	0.0363	7.3	86.5	6.2	Neutral
LAML	Acute Myeloid Leukemia	166	0.078	0.321	0	98.2	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.161	0.000252	4.5	89.7	5.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.437	2.22e-18	1.9	25.8	72.3	Gain
LUAD	Lung adenocarcinoma	512	0.413	1.58e-22	5.3	27	67.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.47	8.58e-29	6.2	43	50.8	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.475	2.61e-18	14.3	42	43.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.495	2.48e-12	4.5	65.5	29.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.364	1.95e-06	9.3	75.3	15.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.195	1.4e-05	5.3	88.4	6.3	Neutral
READ	Rectum adenocarcinoma	164	0.464	4.03e-10	11	59.1	29.9	Neutral
SARC	Sarcoma	255	0.233	0.000175	32.5	53.3	14.1	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.566	1.96e-32	6.5	42.5	51	Gain
STAD	Stomach adenocarcinoma	413	0.434	2.27e-20	5.3	65.4	29.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.401	3.64e-07	4.7	50	45.3	Gain
THCA	Thyroid carcinoma	497	0.361	9e-17	0.6	93.8	5.6	Neutral
THYM	Thymoma	119	0.179	0.0514	0	78.2	21.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.395	1.67e-21	3.5	55.9	40.6	Gain

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.183	0.000156	17	408	-0.001	0.286	NS/NA
BRCA	Breast invasive carcinoma	-0.072	0.0331	83	785	0.001	0.0298	NS/NA
CESC	Cervical and endocervical cancers	-0.043	0.446	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.078	0.166	19	297	0	0.891	NS/NA
ESCA	Esophageal carcinoma	-0.112	0.121	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.175	0.163	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.111	0.00951	20	522	-0.008	0.000531	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.016	0.762	24	319	0.001	0.466	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.142	0.0145	23	275	-0.014	0.00185	NS/NA
LAML	Acute Myeloid Leukemia	-0.101	0.19	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.145	8e-04	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.233	1.8e-06	41	373	-0.001	0.00655	NS/NA
LUAD	Lung adenocarcinoma	-0.069	0.134	21	456	-0.006	0.134	NS/NA
LUSC	Lung squamous cell carcinoma	-0.119	0.0204	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.112	0.131	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.181	0.0134	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.2	3.42e-06	35	498	-0.023	2.97e-08	NS/NA
READ	Rectum adenocarcinoma	-0.116	0.247	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.114	0.0661	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.279	8.31e-10	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.146	0.00479	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.056	0.484	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.029	0.488	50	509	0	0.0195	NS/NA
THYM	Thymoma	-0.065	0.476	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.192	3.04e-05	34	431	-0.002	0.00626	NS/NA

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	1	Low
Small intestine	3	High
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	2	Medium
Testis	3	High
Thyroid gland	3	High
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	0	Not detected

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.426	NS	24476821
BRCA	Breast invasive carcinoma	521	6.32e-19	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00401	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000649	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.35e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.127	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.99e-19	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0037	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00268	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.412	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.00799	Significant	26544944
READ	Rectum adenocarcinoma	67	0.00908	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000284	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.72e-09	Significant	25079317
THCA	Thyroid carcinoma	391	0.0113	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	4.75e-11	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.362	0.158	NS
BRCA	Breast invasive carcinoma	1079	1.121	0.607	NS
CESC	Cervical and endocervical cancers	291	3.387	0.000496	Shorter
COAD	Colon adenocarcinoma	439	0.943	0.835	NS
ESCA	Esophageal carcinoma	184	1.068	0.861	NS
GBM	Glioblastoma multiforme	158	1.108	0.698	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.265	0.223	NS
KIRC	Kidney renal clear cell carcinoma	531	0.677	0.0663	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.785	0.515	NS
LAML	Acute Myeloid Leukemia	149	0.755	0.356	NS
LGG	Brain Lower Grade Glioma	511	3.799	1.38e-06	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.066	0.807	NS
LUAD	Lung adenocarcinoma	502	1.145	0.506	NS
LUSC	Lung squamous cell carcinoma	494	0.904	0.611	NS
OV	Ovarian serous cystadenocarcinoma	303	0.786	0.259	NS
PAAD	Pancreatic adenocarcinoma	177	1.375	0.302	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.962	0.978	NS
PRAD	Prostate adenocarcinoma	497	1.787	0.519	NS
READ	Rectum adenocarcinoma	159	0.698	0.518	NS
SARC	Sarcoma	259	2.053	0.0201	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.367	0.111	NS
STAD	Stomach adenocarcinoma	388	0.919	0.706	NS
TGCT	Testicular Germ Cell Tumors	134	0.595	0.669	NS
THCA	Thyroid carcinoma	500	1.027	0.969	NS
THYM	Thymoma	119	4.167	0.161	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.562	0.0545	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.076	0.127	NS
BRCA	Breast invasive carcinoma	1071	0.053	0.0852	NS
CESC	Cervical and endocervical cancers	167	0.14	0.0709	NS
COAD	Colon adenocarcinoma	445	-0.012	0.794	NS
ESCA	Esophageal carcinoma	162	-0.035	0.655	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.004	0.924	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.011	0.796	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.011	0.854	NS
LIHC	Liver hepatocellular carcinoma	347	0.011	0.839	NS
LUAD	Lung adenocarcinoma	507	0.041	0.36	NS
LUSC	Lung squamous cell carcinoma	497	-0.003	0.952	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.036	0.53	NS
PAAD	Pancreatic adenocarcinoma	176	0.055	0.469	NS
READ	Rectum adenocarcinoma	156	-0.002	0.976	NS
SKCM	Skin Cutaneous Melanoma	410	-0.062	0.213	NS
STAD	Stomach adenocarcinoma	392	-0.06	0.233	NS
TGCT	Testicular Germ Cell Tumors	81	-0.238	0.0326	Lower
THCA	Thyroid carcinoma	499	0.004	0.935	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.162	0.00028	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.082	0.178	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.017	0.707	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.024	0.585	NS
LGG	Brain Lower Grade Glioma	514	0.176	6.18e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.004	0.94	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.03	0.606	NS
PAAD	Pancreatic adenocarcinoma	176	0.14	0.0632	NS
STAD	Stomach adenocarcinoma	406	-0.121	0.0145	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.242	1.59e-08	Lower

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMYD2.

Summary
Symbol	SMYD2
Name	SET and MYND domain containing 2
Aliases	HSKM-B; ZMYND14; KMT3C; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N- ......
Location	1q32.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26826421	Head and Neck Squamous Cell Carcinoma	partner	p53	Interaction	In both nonmultiple and multiple groups, the combination of SMYD2 and p53 immunopositivity was a significant prognostic indicator (P = .027 and .015).
26790435	Chronic Lymphocytic Leukemia	partner	SMYD3	Correlation	Furthermore, a strong correlation between SMYD2 and SMYD3 gene expression was unveiled. Our data demonstrate the association of a residual expression of SMYD2 and SMYD3 with CLL progression indicators and suggests both genes are regulated by a common transcriptional control in this type of cancer.