CR2Cancer

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00856 SET domain
PF01753 MYND finger

Function

Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3K4, H3K5	H3K4me2, H3K4me3, H3K5me2, H3K5me3	15235609

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006469 negative regulation of protein kinase activity GO:0006479 protein methylation GO:0008213 protein alkylation GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018105 peptidyl-serine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018209 peptidyl-serine modification GO:0031497 chromatin assembly GO:0031960 response to corticosteroid GO:0032259 methylation GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033673 negative regulation of kinase activity GO:0034728 nucleosome organization GO:0034968 histone lysine methylation GO:0042326 negative regulation of phosphorylation GO:0042692 muscle cell differentiation GO:0043414 macromolecule methylation GO:0048545 response to steroid hormone GO:0051146 striated muscle cell differentiation GO:0051348 negative regulation of transferase activity GO:0051384 response to glucocorticoid GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0071824 protein-DNA complex subunit organization GO:1901654 response to ketone GO:1901655 cellular response to ketone
Molecular Function	GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000993 RNA polymerase II core binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0001161 intronic transcription regulatory region sequence-specific DNA binding GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0043175 RNA polymerase core enzyme binding GO:0044213 intronic transcription regulatory region DNA binding GO:0070063 RNA polymerase binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214841: PKMTs methylate histone lysines

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM273283	c.1086C>T	p.C362C	Substitution - coding silent	Large_intestine
COSM3486480	c.368C>T	p.S123F	Substitution - Missense	Skin
COSM4030436	c.625A>G	p.T209A	Substitution - Missense	Stomach
COSM3486480	c.368C>T	p.S123F	Substitution - Missense	Skin
COSM1226917	c.908T>C	p.F303S	Substitution - Missense	Large_intestine
COSM5950783	c.684A>T	p.Q228H	Substitution - Missense	Prostate
COSM273283	c.1086C>T	p.C362C	Substitution - coding silent	Stomach
COSM273283	c.1086C>T	p.C362C	Substitution - coding silent	Large_intestine
COSM3667498	c.995A>G	p.K332R	Substitution - Missense	Liver
COSM5952375	c.711G>C	p.L237L	Substitution - coding silent	Oesophagus
COSM277402	c.167G>T	p.G56V	Substitution - Missense	Large_intestine
COSM4953469	c.602A>T	p.E201V	Substitution - Missense	Liver
COSM5135397	c.354+3_354+6delAAGT	p.?	Unknown	Large_intestine
COSM5425730	c.326C>T	p.A109V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4522754	c.1002G>A	p.L334L	Substitution - coding silent	Skin
COSM4143621	c.816C>T	p.L272L	Substitution - coding silent	Thyroid
COSM1639784	c.764G>A	p.S255N	Substitution - Missense	Stomach
COSM4030430	c.1004G>C	p.R335T	Substitution - Missense	Stomach
COSM4514097	c.785C>T	p.P262L	Substitution - Missense	Skin
COSM3486478	c.426C>T	p.I142I	Substitution - coding silent	Skin
COSM4941233	c.864C>T	p.A288A	Substitution - coding silent	Liver
COSM5992557	c.671G>T	p.W224L	Substitution - Missense	Prostate
COSM2051952	c.462G>A	p.S154S	Substitution - coding silent	Large_intestine
COSM285228	c.1081G>T	p.E361*	Substitution - Nonsense	Large_intestine
COSM1340894	c.21C>T	p.R7R	Substitution - coding silent	Large_intestine
COSM1296119	c.798C>G	p.I266M	Substitution - Missense	Urinary_tract
COSM323495	c.754G>T	p.A252S	Substitution - Missense	Lung
COSM906835	c.423-1G>A	p.?	Unknown	Endometrium
COSM4764961	c.925G>A	p.V309I	Substitution - Missense	Breast
COSM4519975	c.859G>A	p.E287K	Substitution - Missense	Skin
COSM5425730	c.326C>T	p.A109V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2151720	c.699A>C	p.K233N	Substitution - Missense	Central_nervous_system
COSM1724305	c.423-5delT	p.?	Unknown	Stomach
COSM400993	c.795C>T	p.N265N	Substitution - coding silent	Lung
COSM5613964	c.764G>T	p.S255I	Substitution - Missense	Lung
COSM5604962	c.128T>A	p.V43D	Substitution - Missense	Skin
COSM5962240	c.294A>G	p.E98E	Substitution - coding silent	Breast
COSM3486474	c.672G>A	p.W224*	Substitution - Nonsense	Skin
COSM2051977	c.58G>A	p.A20T	Substitution - Missense	Stomach
COSM2051925	c.908delT	p.F303fs*12	Deletion - Frameshift	Large_intestine
COSM4563246	c.787G>A	p.D263N	Substitution - Missense	Skin
COSM139369	c.418C>T	p.P140S	Substitution - Missense	Skin
COSM3486484	c.125C>T	p.S42F	Substitution - Missense	Skin
COSM906831	c.1037G>T	p.G346V	Substitution - Missense	Endometrium
COSM1602045	c.510C>A	p.I170I	Substitution - coding silent	Liver
COSM2051950	c.510C>T	p.I170I	Substitution - coding silent	Breast
COSM4551632	c.357G>A	p.V119V	Substitution - coding silent	Skin
COSM4030432	c.755C>T	p.A252V	Substitution - Missense	Stomach
COSM5014202	c.483C>A	p.H161Q	Substitution - Missense	Kidney
COSM3710882	c.505G>C	p.D169H	Substitution - Missense	Upper_aerodigestive_tract
COSM5930740	c.773C>T	p.S258F	Substitution - Missense	Skin
COSM3804656	c.265G>C	p.V89L	Substitution - Missense	Breast
COSM4030434	c.663G>A	p.E221E	Substitution - coding silent	Stomach
COSM4448571	c.900-1G>A	p.?	Unknown	Skin
COSM5880270	c.910C>T	p.P304S	Substitution - Missense	Skin
COSM273283	c.1086C>T	p.C362C	Substitution - coding silent	Stomach
COSM5992557	c.671G>T	p.W224L	Substitution - Missense	Prostate
COSM5735925	c.1054A>G	p.I352V	Substitution - Missense	Small_intestine
COSM906834	c.450C>T	p.D150D	Substitution - coding silent	Endometrium
COSM1734035	c.461C>T	p.S154L	Substitution - Missense	Pancreas
COSM5992557	c.671G>T	p.W224L	Substitution - Missense	Prostate
COSM1226919	c.127G>A	p.V43I	Substitution - Missense	Large_intestine
COSM4563246	c.787G>A	p.D263N	Substitution - Missense	Skin
COSM3710882	c.505G>C	p.D169H	Substitution - Missense	Upper_aerodigestive_tract
COSM5799658	c.822C>T	p.C274C	Substitution - coding silent	Breast
COSM2051940	c.666A>G	p.Q222Q	Substitution - coding silent	Large_intestine
COSM3486476	c.615C>T	p.F205F	Substitution - coding silent	Skin
COSM3486472	c.909C>T	p.F303F	Substitution - coding silent	Skin
COSM5552786	c.388G>T	p.E130*	Substitution - Nonsense	Prostate
COSM425843	c.301C>T	p.Q101*	Substitution - Nonsense	Breast
COSM1492018	c.83G>A	p.C28Y	Substitution - Missense	Kidney
COSM679569	c.75G>A	p.K25K	Substitution - coding silent	Lung
COSM4960038	c.564G>A	p.E188E	Substitution - coding silent	Liver
COSM2051950	c.510C>T	p.I170I	Substitution - coding silent	Skin
COSM3486470	c.942G>A	p.V314V	Substitution - coding silent	Skin
COSM906837	c.368_369delCT	p.S123fs*5	Deletion - Frameshift	Endometrium
COSM3774452	c.518G>C	p.G173A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM906833	c.636+2T>C	p.?	Unknown	Endometrium
COSM1724305	c.423-5delT	p.?	Unknown	Skin
COSM4439030	c.148G>T	p.V50F	Substitution - Missense	Oesophagus
COSM4778420	c.399A>C	p.E133D	Substitution - Missense	Liver
COSM906832	c.701T>G	p.I234S	Substitution - Missense	Endometrium
COSM5380333	c.511G>A	p.E171K	Substitution - Missense	Skin
COSM3486482	c.153C>T	p.F51F	Substitution - coding silent	Skin
COSM1340892	c.52-1G>A	p.?	Unknown	Large_intestine
COSM2151720	c.699A>C	p.K233N	Substitution - Missense	Central_nervous_system
COSM4514083	c.784C>T	p.P262S	Substitution - Missense	Skin
COSM5948533	c.355G>A	p.V119M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1340885	c.700_701insA	p.I234fs*2	Insertion - Frameshift	Large_intestine
COSM4999379	c.599T>C	p.F200S	Substitution - Missense	Pancreas
COSM3667498	c.995A>G	p.K332R	Substitution - Missense	Liver
COSM4509001	c.616C>T	p.R206C	Substitution - Missense	Skin
COSM4728612	c.494G>A	p.R165Q	Substitution - Missense	Large_intestine
COSM425841	c.528C>T	p.L176L	Substitution - coding silent	Breast
COSM2051950	c.510C>T	p.I170I	Substitution - coding silent	Breast
COSM2051925	c.908delT	p.F303fs*12	Deletion - Frameshift	Stomach
COSM679570	c.531C>A	p.T177T	Substitution - coding silent	Lung
COSM5815995	c.354A>C	p.K118N	Substitution - Missense	Liver
COSM4944111	c.1087G>A	p.D363N	Substitution - Missense	Liver
COSM2051925	c.908delT	p.F303fs*12	Deletion - Frameshift	Large_intestine
COSM4764961	c.925G>A	p.V309I	Substitution - Missense	Stomach
COSM350020	c.466G>T	p.V156L	Substitution - Missense	Lung
COSM3727108	c.143G>A	p.R48K	Substitution - Missense	Skin
COSM906838	c.98G>T	p.S33I	Substitution - Missense	Endometrium
COSM1266320	c.724+1G>T	p.?	Unknown	Stomach
COSM4960038	c.564G>A	p.E188E	Substitution - coding silent	Liver
COSM350019	c.1078G>C	p.E360Q	Substitution - Missense	Lung
COSM425842	c.443G>T	p.S148I	Substitution - Missense	Breast
COSM4953469	c.602A>T	p.E201V	Substitution - Missense	Liver
COSM1492016	c.79G>A	p.E27K	Substitution - Missense	Kidney
COSM5816574	c.803A>T	p.Q268L	Substitution - Missense	Liver
COSM906836	c.381T>C	p.C127C	Substitution - coding silent	Endometrium
COSM2051925	c.908delT	p.F303fs*12	Deletion - Frameshift	Large_intestine
COSM5697689	c.79G>T	p.E27*	Substitution - Nonsense	Soft_tissue
COSM4766036	c.106_107insA	p.P36fs*34	Insertion - Frameshift	Stomach
COSM5880270	c.910C>T	p.P304S	Substitution - Missense	Skin
COSM425840	c.1040G>A	p.R347K	Substitution - Missense	Breast
COSM2051925	c.908delT	p.F303fs*12	Deletion - Frameshift	Large_intestine
COSM4728614	c.308C>T	p.A103V	Substitution - Missense	Large_intestine
COSM4030432	c.755C>T	p.A252V	Substitution - Missense	Prostate
COSM679571	c.643G>A	p.D215N	Substitution - Missense	Lung
COSM4764961	c.925G>A	p.V309I	Substitution - Missense	Large_intestine

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
18294291	Mutation	Esophageal Squamous Cell Carcinoma	These findings provide additional evidence that the common VNTR polymorphism in the promoter region of SMYD3 gene may be a susceptibility factor for human cancers such as ESCC by interacting with tobacco carcinogens.
16155568	Overexpression; Mutation	Colorectal Carcinoma; Hepatocellular Carcinoma	We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas. These data suggest that the common variable number of tandem repeats polymorphism in SMYD3 is a susceptibility factor for some types of human cancer.

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9H7B4	22	T	Phosphothreonine	-	No	None detected

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.56	3.824	0.442	0.14	NS
BRCA	Breast invasive carcinoma	112	1100	3.261	4.42	1.249	4.96e-39	Over
CESC	Cervical and endocervical cancers	3	306	3.248	3.163	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.838	3.891	1.114	1.94e-26	Over
ESCA	Esophageal carcinoma	11	185	2.75	3.138	0.419	0.197	NS
GBM	Glioblastoma multiforme	5	166	4.353	4.153	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	2.221	3.054	0.826	2.35e-08	Over
KIRC	Kidney renal clear cell carcinoma	72	534	3.393	3.377	-0.066	0.363	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.344	3.33	-0.04	0.765	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.011	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.965	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	1.758	3.112	1.401	8.58e-18	Over
LUAD	Lung adenocarcinoma	59	517	3.518	4.041	0.506	9.76e-07	NS
LUSC	Lung squamous cell carcinoma	51	501	3.492	3.803	0.367	0.00071	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.006	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.22	3.782	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.93	3.436	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.076	3.874	0.765	2.79e-16	Over
READ	Rectum adenocarcinoma	10	167	3.073	4.06	0.939	2.58e-06	Over
SARC	Sarcoma	2	263	3.625	3.414	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.957	3.967	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	2.981	3.219	0.299	0.0159	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.053	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.372	4.093	-0.281	0.00209	NS
THYM	Thymoma	2	120	3.255	4.305	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.501	4.473	0.943	1.16e-14	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.9
Autonomic ganglia	CHP212	9.2
Autonomic ganglia	IMR32	9.4
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	9.5
Autonomic ganglia	KPNSI9S	11.5
Autonomic ganglia	KPNYN	9.9
Autonomic ganglia	MHHNB11	9.4
Autonomic ganglia	NB1	9.8
Autonomic ganglia	NH6	10.3
Autonomic ganglia	SHSY5Y	9.4
Autonomic ganglia	SIMA	9.4
Autonomic ganglia	SKNAS	9.3
Autonomic ganglia	SKNBE2	11.2
Autonomic ganglia	SKNDZ	9
Autonomic ganglia	SKNFI	7
Autonomic ganglia	SKNSH	9.1
Biliary tract	HUCCT1	8.8
Biliary tract	HUH28	9.8
Biliary tract	SNU1079	9.4
Biliary tract	SNU1196	7.7
Biliary tract	SNU245	8.4
Biliary tract	SNU308	8.2
Biliary tract	SNU478	7.8
Bone	143B	8.7
Bone	A673	9.4
Bone	CADOES1	9.1
Bone	CAL78	9.4
Bone	G292CLONEA141B1	8.3
Bone	HOS	8.4
Bone	HS706T	10.2
Bone	HS737T	10.8
Bone	HS819T	9.1
Bone	HS821T	7.7
Bone	HS822T	10.6
Bone	HS863T	8.5
Bone	HS870T	9.7
Bone	HS888T	8.9
Bone	MG63	8.9
Bone	MHHES1	10
Bone	OUMS27	8.8
Bone	RDES	9.3
Bone	SJSA1	9.2
Bone	SKES1	9.6
Bone	SKNMC	9.3
Bone	SW1353	12.1
Bone	T173	9.3
Bone	TC71	9.1
Bone	U2OS	8.8
Breast	AU565	5.7
Breast	BT20	8.7
Breast	BT474	8.7
Breast	BT483	9.2
Breast	BT549	8.2
Breast	CAL120	9.4
Breast	CAL148	6.9
Breast	CAL51	8.5
Breast	CAL851	7.6
Breast	CAMA1	8.8
Breast	DU4475	12.5
Breast	EFM192A	9.6
Breast	EFM19	9.6
Breast	EVSAT	7.5
Breast	HCC1143	9.2
Breast	HCC1187	8.6
Breast	HCC1395	8.7
Breast	HCC1419	8.3
Breast	HCC1428	10.7
Breast	HCC1500	8.2
Breast	HCC1569	10.1
Breast	HCC1599	8.2
Breast	HCC1806	8.5
Breast	HCC1937	7.3
Breast	HCC1954	8
Breast	HCC202	9.4
Breast	HCC2157	9.4
Breast	HCC2218	10.2
Breast	HCC38	8.9
Breast	HCC70	8.2
Breast	HDQP1	7.9
Breast	HMC18	8.3
Breast	HS274T	8
Breast	HS281T	9.8
Breast	HS343T	9.1
Breast	HS578T	10.4
Breast	HS606T	9
Breast	HS739T	10.6
Breast	HS742T	10.1
Breast	JIMT1	7.3
Breast	KPL1	10
Breast	MCF7	9.6
Breast	MDAMB134VI	8.7
Breast	MDAMB157	10.5
Breast	MDAMB175VII	9.3
Breast	MDAMB231	9.4
Breast	MDAMB361	8.4
Breast	MDAMB415	8.6
Breast	MDAMB436	9.1
Breast	MDAMB453	7.8
Breast	MDAMB468	7.6
Breast	SKBR3	5.2
Breast	T47D	8.5
Breast	UACC812	7.9
Breast	UACC893	8.9
Breast	YMB1	5.3
Breast	ZR751	8.1
Breast	ZR7530	10.7
Central nervous system	1321N1	8.9
Central nervous system	42MGBA	9.1
Central nervous system	8MGBA	9.3
Central nervous system	A172	8.7
Central nervous system	AM38	9.1
Central nervous system	BECKER	8.5
Central nervous system	CAS1	8.9
Central nervous system	CCFSTTG1	9.4
Central nervous system	D283MED	9.7
Central nervous system	D341MED	9.9
Central nervous system	DAOY	8.1
Central nervous system	DBTRG05MG	8.5
Central nervous system	DKMG	7.9
Central nervous system	GAMG	8.2
Central nervous system	GB1	8.3
Central nervous system	GI1	11.2
Central nervous system	GMS10	8.9
Central nervous system	GOS3	8.4
Central nervous system	H4	9.5
Central nervous system	HS683	8.5
Central nervous system	KALS1	8.8
Central nervous system	KG1C	8.6
Central nervous system	KNS42	9
Central nervous system	KNS60	10.3
Central nervous system	KNS81	9
Central nervous system	KS1	8.9
Central nervous system	LN18	7.6
Central nervous system	LN229	9.1
Central nervous system	M059K	9.1
Central nervous system	MOGGCCM	10
Central nervous system	MOGGUVW	9.9
Central nervous system	NMCG1	9
Central nervous system	ONS76	8.9
Central nervous system	SF126	8.7
Central nervous system	SF295	9.5
Central nervous system	SNB19	9.5
Central nervous system	SNU1105	9.9
Central nervous system	SNU201	8.9
Central nervous system	SNU466	8.1
Central nervous system	SNU489	11.5
Central nervous system	SNU626	8.9
Central nervous system	SNU738	8.5
Central nervous system	SW1088	8.7
Central nervous system	SW1783	9
Central nervous system	T98G	9.2
Central nervous system	TM31	9.7
Central nervous system	U118MG	8.3
Central nervous system	U138MG	8.6
Central nervous system	U251MG	10.1
Central nervous system	U87MG	9.6
Central nervous system	YH13	8.8
Central nervous system	YKG1	8.8
Endometrium	AN3CA	8
Endometrium	COLO684	9.7
Endometrium	EFE184	8.6
Endometrium	EN	9
Endometrium	ESS1	8.9
Endometrium	HEC108	8.2
Endometrium	HEC151	8.5
Endometrium	HEC1A	9.5
Endometrium	HEC1B	9.2
Endometrium	HEC251	8.7
Endometrium	HEC265	8.5
Endometrium	HEC50B	9
Endometrium	HEC59	8.3
Endometrium	HEC6	9.5
Endometrium	ISHIKAWAHERAKLIO02ER	8.5
Endometrium	JHUEM1	8.6
Endometrium	JHUEM2	9.3
Endometrium	JHUEM3	8.9
Endometrium	KLE	9.8
Endometrium	MFE280	9.8
Endometrium	MFE296	9.4
Endometrium	MFE319	8.6
Endometrium	RL952	8.4
Endometrium	SNGM	9.2
Endometrium	SNU1077	9.6
Endometrium	SNU685	9.1
Endometrium	TEN	9
Haematopoietic and lymphoid	697	9.3
Haematopoietic and lymphoid	A3KAW	9.5
Haematopoietic and lymphoid	A4FUK	7.4
Haematopoietic and lymphoid	ALLSIL	9.4
Haematopoietic and lymphoid	AML193	9.8
Haematopoietic and lymphoid	AMO1	8.8
Haematopoietic and lymphoid	BCP1	11.1
Haematopoietic and lymphoid	BDCM	9
Haematopoietic and lymphoid	BL41	8.8
Haematopoietic and lymphoid	BL70	9
Haematopoietic and lymphoid	BV173	9.5
Haematopoietic and lymphoid	CA46	9.8
Haematopoietic and lymphoid	CI1	9.2
Haematopoietic and lymphoid	CMK115	10.1
Haematopoietic and lymphoid	CMK86	9.4
Haematopoietic and lymphoid	CMK	9.5
Haematopoietic and lymphoid	CMLT1	8.9
Haematopoietic and lymphoid	COLO775	10.5
Haematopoietic and lymphoid	DAUDI	9.6
Haematopoietic and lymphoid	DB	10.1
Haematopoietic and lymphoid	DEL	13.4
Haematopoietic and lymphoid	DND41	9.9
Haematopoietic and lymphoid	DOHH2	9
Haematopoietic and lymphoid	EB1	9
Haematopoietic and lymphoid	EB2	9.7
Haematopoietic and lymphoid	EHEB	8.4
Haematopoietic and lymphoid	EJM	7.6
Haematopoietic and lymphoid	EM2	8.7
Haematopoietic and lymphoid	EOL1	11.7
Haematopoietic and lymphoid	F36P	12.2
Haematopoietic and lymphoid	GA10	9.4
Haematopoietic and lymphoid	GDM1	12.7
Haematopoietic and lymphoid	GRANTA519	7.8
Haematopoietic and lymphoid	HDLM2	8.8
Haematopoietic and lymphoid	HDMYZ	8.5
Haematopoietic and lymphoid	HEL9217	9.3
Haematopoietic and lymphoid	HEL	9.3
Haematopoietic and lymphoid	HH	9.8
Haematopoietic and lymphoid	HL60	8.4
Haematopoietic and lymphoid	HPBALL	9.9
Haematopoietic and lymphoid	HS604T	8.4
Haematopoietic and lymphoid	HS611T	8.5
Haematopoietic and lymphoid	HS616T	9.1
Haematopoietic and lymphoid	HS751T	8.3
Haematopoietic and lymphoid	HT	8.7
Haematopoietic and lymphoid	HTK	8.6
Haematopoietic and lymphoid	HUNS1	8.6
Haematopoietic and lymphoid	HUT102	8.2
Haematopoietic and lymphoid	HUT78	8.7
Haematopoietic and lymphoid	JEKO1	10.3
Haematopoietic and lymphoid	JK1	12
Haematopoietic and lymphoid	JM1	9.6
Haematopoietic and lymphoid	JURKAT	9.1
Haematopoietic and lymphoid	JURLMK1	8.9
Haematopoietic and lymphoid	JVM2	7.9
Haematopoietic and lymphoid	JVM3	9.6
Haematopoietic and lymphoid	K562	12.4
Haematopoietic and lymphoid	KARPAS299	11.8
Haematopoietic and lymphoid	KARPAS422	10.1
Haematopoietic and lymphoid	KARPAS620	8.6
Haematopoietic and lymphoid	KASUMI1	9.5
Haematopoietic and lymphoid	KASUMI2	9.4
Haematopoietic and lymphoid	KASUMI6	11.6
Haematopoietic and lymphoid	KCL22	11.8
Haematopoietic and lymphoid	KE37	9.2
Haematopoietic and lymphoid	KE97	8.3
Haematopoietic and lymphoid	KG1	10.4
Haematopoietic and lymphoid	KHM1B	6.7
Haematopoietic and lymphoid	KIJK	11.9
Haematopoietic and lymphoid	KMH2	8.9
Haematopoietic and lymphoid	KMM1	9.8
Haematopoietic and lymphoid	KMS11	8.7
Haematopoietic and lymphoid	KMS12BM	8.7
Haematopoietic and lymphoid	KMS18	8.3
Haematopoietic and lymphoid	KMS20	8.1
Haematopoietic and lymphoid	KMS21BM	9.9
Haematopoietic and lymphoid	KMS26	6.9
Haematopoietic and lymphoid	KMS27	6.7
Haematopoietic and lymphoid	KMS28BM	8.2
Haematopoietic and lymphoid	KMS34	8
Haematopoietic and lymphoid	KO52	9.7
Haematopoietic and lymphoid	KOPN8	8.8
Haematopoietic and lymphoid	KU812	9.3
Haematopoietic and lymphoid	KYO1	11.2
Haematopoietic and lymphoid	L1236	9
Haematopoietic and lymphoid	L363	7.9
Haematopoietic and lymphoid	L428	8.3
Haematopoietic and lymphoid	L540	10.1
Haematopoietic and lymphoid	LAMA84	11.4
Haematopoietic and lymphoid	LOUCY	9.8
Haematopoietic and lymphoid	LP1	6.5
Haematopoietic and lymphoid	M07E	9.3
Haematopoietic and lymphoid	MC116	9.1
Haematopoietic and lymphoid	ME1	12.3
Haematopoietic and lymphoid	MEC1	8.7
Haematopoietic and lymphoid	MEC2	8.6
Haematopoietic and lymphoid	MEG01	10.5
Haematopoietic and lymphoid	MHHCALL2	8.4
Haematopoietic and lymphoid	MHHCALL3	9.5
Haematopoietic and lymphoid	MHHCALL4	8.7
Haematopoietic and lymphoid	MINO	8.7
Haematopoietic and lymphoid	MJ	8.9
Haematopoietic and lymphoid	MM1S	8
Haematopoietic and lymphoid	MOLM13	10.1
Haematopoietic and lymphoid	MOLM16	8.6
Haematopoietic and lymphoid	MOLM6	11.6
Haematopoietic and lymphoid	MOLP2	6.9
Haematopoietic and lymphoid	MOLP8	8.7
Haematopoietic and lymphoid	MOLT13	8.6
Haematopoietic and lymphoid	MOLT16	9.2
Haematopoietic and lymphoid	MOLT4	9.7
Haematopoietic and lymphoid	MONOMAC1	10.8
Haematopoietic and lymphoid	MONOMAC6	10.9
Haematopoietic and lymphoid	MOTN1	9.1
Haematopoietic and lymphoid	MUTZ5	9.5
Haematopoietic and lymphoid	MV411	12.1
Haematopoietic and lymphoid	NALM19	9.5
Haematopoietic and lymphoid	NALM1	9.1
Haematopoietic and lymphoid	NALM6	9.1
Haematopoietic and lymphoid	NAMALWA	9.2
Haematopoietic and lymphoid	NB4	8.9
Haematopoietic and lymphoid	NCIH929	8.5
Haematopoietic and lymphoid	NCO2	10.3
Haematopoietic and lymphoid	NOMO1	12.4
Haematopoietic and lymphoid	NUDHL1	11.3
Haematopoietic and lymphoid	NUDUL1	8.5
Haematopoietic and lymphoid	OCIAML2	12.7
Haematopoietic and lymphoid	OCIAML3	12.9
Haematopoietic and lymphoid	OCIAML5	11.2
Haematopoietic and lymphoid	OCILY10	9.8
Haematopoietic and lymphoid	OCILY19	9.4
Haematopoietic and lymphoid	OCILY3	8.9
Haematopoietic and lymphoid	OCIM1	9.3
Haematopoietic and lymphoid	OPM2	6.9
Haematopoietic and lymphoid	P12ICHIKAWA	9.4
Haematopoietic and lymphoid	P31FUJ	10.3
Haematopoietic and lymphoid	P3HR1	8.9
Haematopoietic and lymphoid	PCM6	9.9
Haematopoietic and lymphoid	PEER	9.5
Haematopoietic and lymphoid	PF382	8.6
Haematopoietic and lymphoid	PFEIFFER	8.8
Haematopoietic and lymphoid	PL21	9.3
Haematopoietic and lymphoid	RAJI	8.5
Haematopoietic and lymphoid	RCHACV	9.4
Haematopoietic and lymphoid	REC1	9.2
Haematopoietic and lymphoid	REH	9.5
Haematopoietic and lymphoid	RI1	9.3
Haematopoietic and lymphoid	RL	7.9
Haematopoietic and lymphoid	RPMI8226	11.8
Haematopoietic and lymphoid	RPMI8402	9.8
Haematopoietic and lymphoid	RS411	8.7
Haematopoietic and lymphoid	SEM	8.8
Haematopoietic and lymphoid	SET2	8.6
Haematopoietic and lymphoid	SIGM5	10.2
Haematopoietic and lymphoid	SKM1	9.9
Haematopoietic and lymphoid	SKMM2	8.3
Haematopoietic and lymphoid	SR786	13.3
Haematopoietic and lymphoid	ST486	8.7
Haematopoietic and lymphoid	SUDHL10	10
Haematopoietic and lymphoid	SUDHL1	9.8
Haematopoietic and lymphoid	SUDHL4	9.2
Haematopoietic and lymphoid	SUDHL5	7.4
Haematopoietic and lymphoid	SUDHL6	9.1
Haematopoietic and lymphoid	SUDHL8	9.7
Haematopoietic and lymphoid	SUPB15	9.4
Haematopoietic and lymphoid	SUPHD1	10
Haematopoietic and lymphoid	SUPM2	11.7
Haematopoietic and lymphoid	SUPT11	10
Haematopoietic and lymphoid	SUPT1	8.9
Haematopoietic and lymphoid	TALL1	9.7
Haematopoietic and lymphoid	TF1	12.2
Haematopoietic and lymphoid	THP1	12.3
Haematopoietic and lymphoid	TO175T	8.3
Haematopoietic and lymphoid	TOLEDO	9.8
Haematopoietic and lymphoid	U266B1	7.7
Haematopoietic and lymphoid	U937	10.5
Haematopoietic and lymphoid	UT7	11.1
Haematopoietic and lymphoid	WSUDLCL2	10.1
Kidney	769P	9.8
Kidney	786O	8.9
Kidney	A498	9.1
Kidney	A704	8.5
Kidney	ACHN	9
Kidney	BFTC909	10.6
Kidney	CAKI1	10
Kidney	CAKI2	8.2
Kidney	CAL54	8
Kidney	KMRC1	9.3
Kidney	KMRC20	8.4
Kidney	KMRC2	9.9
Kidney	KMRC3	8.9
Kidney	OSRC2	8.4
Kidney	RCC10RGB	8.2
Kidney	SNU1272	9.7
Kidney	SNU349	9.1
Kidney	TUHR10TKB	8.8
Kidney	TUHR14TKB	8.9
Kidney	TUHR4TKB	9.2
Kidney	VMRCRCW	7.5
Kidney	VMRCRCZ	11.2
Large intestine	C2BBE1	8.4
Large intestine	CCK81	8
Large intestine	CL11	8.5
Large intestine	CL14	8.3
Large intestine	CL34	8.7
Large intestine	CL40	8
Large intestine	COLO205	10.4
Large intestine	COLO320	9.3
Large intestine	COLO678	7.4
Large intestine	CW2	7.8
Large intestine	DLD1	8.9
Large intestine	GP2D	9
Large intestine	HCC56	8.8
Large intestine	HCT116	8.7
Large intestine	HCT15	8.6
Large intestine	HS675T	8.2
Large intestine	HS698T	10.3
Large intestine	HT115	7.9
Large intestine	HT29	8
Large intestine	HT55	8.9
Large intestine	KM12	8.5
Large intestine	LOVO	8.5
Large intestine	LS1034	7.7
Large intestine	LS123	7.7
Large intestine	LS180	8.7
Large intestine	LS411N	8.3
Large intestine	LS513	7.3
Large intestine	MDST8	9.2
Large intestine	NCIH508	8.6
Large intestine	NCIH716	9
Large intestine	NCIH747	8.6
Large intestine	OUMS23	8.9
Large intestine	RCM1	7.3
Large intestine	RKO	7.9
Large intestine	SKCO1	9.3
Large intestine	SNU1040	8.7
Large intestine	SNU1197	8.4
Large intestine	SNU175	7.7
Large intestine	SNU283	8.7
Large intestine	SNU407	9.1
Large intestine	SNU503	9.3
Large intestine	SNU61	8.5
Large intestine	SNU81	7.2
Large intestine	SNUC1	9.6
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	7.8
Large intestine	SNUC5	9.2
Large intestine	SW1116	6.9
Large intestine	SW1417	8
Large intestine	SW1463	8.6
Large intestine	SW403	9
Large intestine	SW480	8.7
Large intestine	SW48	9.1
Large intestine	SW620	9.8
Large intestine	SW837	8.5
Large intestine	SW948	9.4
Large intestine	T84	8.2
Liver	ALEXANDERCELLS	7.6
Liver	C3A	9.2
Liver	HEP3B217	8.4
Liver	HEPG2	9.2
Liver	HLE	7.9
Liver	HLF	8.6
Liver	HUH1	11.4
Liver	HUH6	8.8
Liver	HUH7	8.7
Liver	JHH1	8.1
Liver	JHH2	8.6
Liver	JHH4	9.3
Liver	JHH5	8.9
Liver	JHH6	9.6
Liver	JHH7	8.5
Liver	LI7	8.3
Liver	PLCPRF5	8.3
Liver	SKHEP1	11
Liver	SNU182	9.5
Liver	SNU387	8.5
Liver	SNU398	9.3
Liver	SNU423	9.4
Liver	SNU449	9.2
Liver	SNU475	9.8
Liver	SNU761	9.3
Liver	SNU878	8.6
Liver	SNU886	7.7
Lung	A549	8.3
Lung	ABC1	8.1
Lung	BEN	12
Lung	CAL12T	8.6
Lung	CALU1	9.2
Lung	CALU3	8.5
Lung	CALU6	8.7
Lung	CHAGOK1	8.3
Lung	COLO668	11.8
Lung	COLO699	8.8
Lung	CORL105	8.1
Lung	CORL23	9.4
Lung	CORL24	9.6
Lung	CORL279	9.1
Lung	CORL311	10
Lung	CORL47	11.3
Lung	CORL51	11.4
Lung	CORL88	12.8
Lung	CORL95	10.9
Lung	CPCN	9.1
Lung	DMS114	9.1
Lung	DMS153	12.1
Lung	DMS273	11.3
Lung	DMS454	11
Lung	DMS53	10.3
Lung	DMS79	10.7
Lung	DV90	8.4
Lung	EBC1	8.2
Lung	EPLC272H	8.9
Lung	HARA	10.7
Lung	HCC1171	8.8
Lung	HCC1195	7.8
Lung	HCC15	8.3
Lung	HCC2279	10
Lung	HCC2935	7.3
Lung	HCC33	9.5
Lung	HCC366	8.2
Lung	HCC4006	8.7
Lung	HCC44	8.7
Lung	HCC78	9.2
Lung	HCC827	8.9
Lung	HCC95	8.3
Lung	HLC1	8.7
Lung	HLFA	8.4
Lung	HS229T	9.1
Lung	HS618T	9
Lung	IALM	9
Lung	KNS62	9.4
Lung	LC1F	10.9
Lung	LC1SQSF	11.3
Lung	LCLC103H	12.1
Lung	LCLC97TM1	8.7
Lung	LK2	8.6
Lung	LOUNH91	9.1
Lung	LU65	9.1
Lung	LU99	9
Lung	LUDLU1	11.1
Lung	LXF289	8.8
Lung	MORCPR	8.9
Lung	NCIH1048	9.9
Lung	NCIH1092	11.7
Lung	NCIH1105	9.4
Lung	NCIH1155	9
Lung	NCIH1184	8.5
Lung	NCIH1299	6.6
Lung	NCIH1339	8.4
Lung	NCIH1341	10.1
Lung	NCIH1355	8.2
Lung	NCIH1373	8.5
Lung	NCIH1385	13.3
Lung	NCIH1395	9.1
Lung	NCIH1435	7.7
Lung	NCIH1436	10
Lung	NCIH1437	10.7
Lung	NCIH146	11.5
Lung	NCIH1563	8.3
Lung	NCIH1568	8
Lung	NCIH1573	9.2
Lung	NCIH1581	8.7
Lung	NCIH1618	9.2
Lung	NCIH1623	7.5
Lung	NCIH1648	8.4
Lung	NCIH1650	8.1
Lung	NCIH1651	9.9
Lung	NCIH1666	8.9
Lung	NCIH1693	8.6
Lung	NCIH1694	10.3
Lung	NCIH1703	8.3
Lung	NCIH1734	8.2
Lung	NCIH1755	9.9
Lung	NCIH1781	8.6
Lung	NCIH1792	8.6
Lung	NCIH1793	8.5
Lung	NCIH1836	11.6
Lung	NCIH1838	7.9
Lung	NCIH1869	9
Lung	NCIH1876	8.6
Lung	NCIH1915	9
Lung	NCIH1930	9.2
Lung	NCIH1944	7.2
Lung	NCIH1963	9.9
Lung	NCIH196	9.6
Lung	NCIH1975	8.9
Lung	NCIH2009	8.3
Lung	NCIH2023	7.6
Lung	NCIH2029	11.8
Lung	NCIH2030	7.6
Lung	NCIH2066	9.2
Lung	NCIH2081	11.8
Lung	NCIH2085	9.1
Lung	NCIH2087	9.9
Lung	NCIH209	11.5
Lung	NCIH2106	10.3
Lung	NCIH2110	9.3
Lung	NCIH211	9.9
Lung	NCIH2122	11.5
Lung	NCIH2126	8.7
Lung	NCIH2141	9.3
Lung	NCIH2170	9.7
Lung	NCIH2171	9.5
Lung	NCIH2172	6.9
Lung	NCIH2196	10.6
Lung	NCIH2227	10.1
Lung	NCIH2228	9.5
Lung	NCIH226	9.8
Lung	NCIH2286	8.8
Lung	NCIH2291	8
Lung	NCIH2342	9.9
Lung	NCIH2347	8.8
Lung	NCIH23	8.2
Lung	NCIH2405	8
Lung	NCIH2444	9.7
Lung	NCIH292	7.3
Lung	NCIH322	9.7
Lung	NCIH3255	8.9
Lung	NCIH358	8.7
Lung	NCIH441	9.6
Lung	NCIH446	9.4
Lung	NCIH460	11.2
Lung	NCIH510	10.7
Lung	NCIH520	9
Lung	NCIH522	9.3
Lung	NCIH524	10.4
Lung	NCIH526	9.8
Lung	NCIH596	8.9
Lung	NCIH647	9.2
Lung	NCIH650	8.2
Lung	NCIH661	8.5
Lung	NCIH69	9.4
Lung	NCIH727	10.2
Lung	NCIH810	11.2
Lung	NCIH82	10.1
Lung	NCIH838	8.3
Lung	NCIH841	9
Lung	NCIH854	9.2
Lung	NCIH889	9.5
Lung	PC14	8.5
Lung	RERFLCAD1	8.8
Lung	RERFLCAD2	7.6
Lung	RERFLCAI	8.4
Lung	RERFLCKJ	9.1
Lung	RERFLCMS	9.1
Lung	RERFLCSQ1	9.3
Lung	SBC5	9.6
Lung	SCLC21H	10
Lung	SHP77	12.3
Lung	SKLU1	9.4
Lung	SKMES1	8.6
Lung	SQ1	9.5
Lung	SW1271	9.8
Lung	SW1573	11.4
Lung	SW900	9.5
Lung	VMRCLCD	11.8
Lung	VMRCLCP	8.4
Oesophagus	COLO680N	8.4
Oesophagus	ECGI10	6.6
Oesophagus	KYSE140	8.5
Oesophagus	KYSE150	9.6
Oesophagus	KYSE180	8.6
Oesophagus	KYSE270	7.1
Oesophagus	KYSE30	7.5
Oesophagus	KYSE410	9.5
Oesophagus	KYSE450	8.3
Oesophagus	KYSE510	8.3
Oesophagus	KYSE520	8.8
Oesophagus	KYSE70	8.8
Oesophagus	OE19	9.2
Oesophagus	OE33	8.5
Oesophagus	TE10	8.5
Oesophagus	TE11	8.4
Oesophagus	TE14	8.2
Oesophagus	TE15	10.6
Oesophagus	TE1	8.7
Oesophagus	TE4	8.3
Oesophagus	TE5	4.8
Oesophagus	TE6	9.3
Oesophagus	TE8	8.6
Oesophagus	TE9	8.4
Oesophagus	TT	8.6
Ovary	59M	10.3
Ovary	A2780	8.6
Ovary	CAOV3	8.4
Ovary	CAOV4	11
Ovary	COLO704	10
Ovary	COV318	9.1
Ovary	COV362	7.9
Ovary	COV434	8.4
Ovary	COV504	8.6
Ovary	COV644	6.8
Ovary	EFO21	8.1
Ovary	EFO27	9.5
Ovary	ES2	9.2
Ovary	FUOV1	8.2
Ovary	HEYA8	8.7
Ovary	HS571T	9.3
Ovary	IGROV1	9.5
Ovary	JHOC5	9
Ovary	JHOM1	10.7
Ovary	JHOM2B	8.5
Ovary	JHOS2	8.6
Ovary	JHOS4	9.4
Ovary	KURAMOCHI	8.8
Ovary	MCAS	9.4
Ovary	NIHOVCAR3	8
Ovary	OAW28	9.1
Ovary	OAW42	8.9
Ovary	OC314	9.4
Ovary	OC316	9
Ovary	ONCODG1	7.7
Ovary	OV56	9.1
Ovary	OV7	9.2
Ovary	OV90	8.1
Ovary	OVCAR4	9.5
Ovary	OVCAR8	10
Ovary	OVISE	8.1
Ovary	OVK18	9.3
Ovary	OVKATE	9
Ovary	OVMANA	6.9
Ovary	OVSAHO	10.1
Ovary	OVTOKO	9
Ovary	RMGI	7.4
Ovary	RMUGS	8.7
Ovary	SKOV3	9.3
Ovary	SNU119	9.9
Ovary	SNU840	8.2
Ovary	SNU8	8.6
Ovary	TOV112D	9.5
Ovary	TOV21G	9.6
Ovary	TYKNU	8.9
Pancreas	ASPC1	7.8
Pancreas	BXPC3	8.1
Pancreas	CAPAN1	8.2
Pancreas	CAPAN2	9
Pancreas	CFPAC1	9.2
Pancreas	DANG	9.7
Pancreas	HPAC	7.9
Pancreas	HPAFII	8.1
Pancreas	HS766T	9
Pancreas	HUPT3	9.2
Pancreas	HUPT4	7.2
Pancreas	KCIMOH1	9
Pancreas	KLM1	7.6
Pancreas	KP2	9.8
Pancreas	KP3	7.6
Pancreas	KP4	8.8
Pancreas	L33	8.5
Pancreas	MIAPACA2	9.2
Pancreas	PANC0203	8.6
Pancreas	PANC0213	7.5
Pancreas	PANC0327	8.4
Pancreas	PANC0403	8.6
Pancreas	PANC0504	7.7
Pancreas	PANC0813	9.2
Pancreas	PANC1005	8.6
Pancreas	PANC1	8.2
Pancreas	PATU8902	9.5
Pancreas	PATU8988S	8.6
Pancreas	PATU8988T	9.2
Pancreas	PK1	9
Pancreas	PK45H	7.1
Pancreas	PK59	6.5
Pancreas	PL45	8.9
Pancreas	PSN1	9.5
Pancreas	QGP1	10.8
Pancreas	SNU213	9.1
Pancreas	SNU324	9.3
Pancreas	SNU410	8.6
Pancreas	SU8686	8.7
Pancreas	SUIT2	7.7
Pancreas	SW1990	9.4
Pancreas	T3M4	7.9
Pancreas	TCCPAN2	8.5
Pancreas	YAPC	8.1
Pleura	ACCMESO1	11
Pleura	DM3	10.1
Pleura	ISTMES1	11.4
Pleura	ISTMES2	8.9
Pleura	JL1	12.1
Pleura	MPP89	9.6
Pleura	MSTO211H	8.7
Pleura	NCIH2052	8.9
Pleura	NCIH2452	7.8
Pleura	NCIH28	9.6
Prostate	22RV1	8.9
Prostate	DU145	9.7
Prostate	LNCAPCLONEFGC	9.4
Prostate	MDAPCA2B	9.5
Prostate	NCIH660	9.2
Prostate	PC3	8.8
Prostate	VCAP	9.7
Salivary gland	A253	7.8
Salivary gland	YD15	8.1
Skin	A101D	8.2
Skin	A2058	8.7
Skin	A375	8.8
Skin	C32	7.8
Skin	CHL1	9.5
Skin	CJM	8.8
Skin	COLO679	9.3
Skin	COLO741	8.1
Skin	COLO783	9.3
Skin	COLO792	7.6
Skin	COLO800	8.9
Skin	COLO818	7.8
Skin	COLO829	8.9
Skin	COLO849	8.8
Skin	G361	7
Skin	GRM	9.1
Skin	HMCB	9.7
Skin	HS294T	8.5
Skin	HS600T	9.3
Skin	HS688AT	9.1
Skin	HS695T	8.2
Skin	HS839T	8.7
Skin	HS852T	8.6
Skin	HS895T	8.9
Skin	HS934T	8.5
Skin	HS936T	9.3
Skin	HS939T	8.7
Skin	HS940T	8.6
Skin	HS944T	8.7
Skin	HT144	8.2
Skin	IGR1	11.2
Skin	IGR37	9.4
Skin	IGR39	8.4
Skin	IPC298	9.3
Skin	K029AX	9.8
Skin	LOXIMVI	8.7
Skin	MALME3M	8.5
Skin	MDAMB435S	9.1
Skin	MELHO	7.8
Skin	MELJUSO	8.5
Skin	MEWO	8.4
Skin	RPMI7951	9
Skin	RVH421	9.3
Skin	SH4	8.9
Skin	SKMEL1	8.3
Skin	SKMEL24	9.2
Skin	SKMEL28	8.4
Skin	SKMEL2	10.6
Skin	SKMEL30	8.8
Skin	SKMEL31	8.9
Skin	SKMEL3	7.8
Skin	SKMEL5	8.2
Skin	UACC257	9.1
Skin	UACC62	9.2
Skin	WM115	9
Skin	WM1799	8.8
Skin	WM2664	9
Skin	WM793	8.7
Skin	WM88	9.3
Skin	WM983B	7.9
Small intestine	HUTU80	9.2
Soft tissue	A204	8.2
Soft tissue	G401	9.3
Soft tissue	G402	8.7
Soft tissue	GCT	8.2
Soft tissue	HS729	8.4
Soft tissue	HT1080	8.4
Soft tissue	KYM1	7.9
Soft tissue	MESSA	8.9
Soft tissue	RD	8.4
Soft tissue	RH30	8.9
Soft tissue	RH41	8.5
Soft tissue	RKN	9.1
Soft tissue	S117	12
Soft tissue	SJRH30	8.5
Soft tissue	SKLMS1	8.2
Soft tissue	SKUT1	9.2
Soft tissue	TE125T	10.4
Soft tissue	TE159T	8.3
Soft tissue	TE441T	8.5
Soft tissue	TE617T	8.1
Stomach	2313287	8.9
Stomach	AGS	10
Stomach	AZ521	8.8
Stomach	ECC10	8.1
Stomach	ECC12	11.2
Stomach	FU97	9.3
Stomach	GCIY	8
Stomach	GSS	10.2
Stomach	GSU	8.1
Stomach	HGC27	9.6
Stomach	HS746T	10.5
Stomach	HUG1N	7.7
Stomach	IM95	7.6
Stomach	KATOIII	4.1
Stomach	KE39	8.2
Stomach	LMSU	11.3
Stomach	MKN1	8.3
Stomach	MKN45	7.4
Stomach	MKN74	8
Stomach	MKN7	5.6
Stomach	NCCSTCK140	6.8
Stomach	NCIN87	8.4
Stomach	NUGC2	8.4
Stomach	NUGC3	9.7
Stomach	NUGC4	5
Stomach	OCUM1	8.3
Stomach	RERFGC1B	5.3
Stomach	SH10TC	7.9
Stomach	SNU16	8.7
Stomach	SNU1	9
Stomach	SNU216	8.4
Stomach	SNU520	8.2
Stomach	SNU5	7.1
Stomach	SNU601	8.2
Stomach	SNU620	8.5
Stomach	SNU668	8
Stomach	SNU719	7.4
Stomach	TGBC11TKB	11.3
Thyroid	8305C	9.5
Thyroid	8505C	8
Thyroid	BCPAP	9.1
Thyroid	BHT101	8.5
Thyroid	CAL62	8.5
Thyroid	CGTHW1	10
Thyroid	FTC133	9.7
Thyroid	FTC238	8.9
Thyroid	ML1	9.4
Thyroid	SW579	8.8
Thyroid	TT2609C02	9.5
Thyroid	TT	11.9
Upper aerodigestive tract	BHY	7.6
Upper aerodigestive tract	BICR16	7.6
Upper aerodigestive tract	BICR18	9.3
Upper aerodigestive tract	BICR22	6.1
Upper aerodigestive tract	BICR31	6.3
Upper aerodigestive tract	BICR56	5.4
Upper aerodigestive tract	BICR6	7.3
Upper aerodigestive tract	CAL27	8.1
Upper aerodigestive tract	CAL33	7.3
Upper aerodigestive tract	DETROIT562	8.4
Upper aerodigestive tract	FADU	8.4
Upper aerodigestive tract	HS840T	9.1
Upper aerodigestive tract	HSC2	7.5
Upper aerodigestive tract	HSC3	9.3
Upper aerodigestive tract	HSC4	7.6
Upper aerodigestive tract	PECAPJ15	7
Upper aerodigestive tract	PECAPJ34CLONEC12	7.6
Upper aerodigestive tract	PECAPJ41CLONED2	9.2
Upper aerodigestive tract	PECAPJ49	8.1
Upper aerodigestive tract	SCC15	7.1
Upper aerodigestive tract	SCC25	7.6
Upper aerodigestive tract	SCC4	8.3
Upper aerodigestive tract	SCC9	5.9
Upper aerodigestive tract	SNU1076	7.9
Upper aerodigestive tract	SNU1214	7.9
Upper aerodigestive tract	SNU46	10.2
Upper aerodigestive tract	SNU899	8.2
Upper aerodigestive tract	YD10B	8.3
Upper aerodigestive tract	YD38	8.5
Upper aerodigestive tract	YD8	8.9
Urinary tract	5637	9
Urinary tract	639V	9.1
Urinary tract	647V	8.1
Urinary tract	BC3C	9.8
Urinary tract	BFTC905	8.3
Urinary tract	CAL29	6.5
Urinary tract	HS172T	7.9
Urinary tract	HT1197	8.4
Urinary tract	HT1376	8.2
Urinary tract	J82	9.4
Urinary tract	JMSU1	8.6
Urinary tract	KMBC2	6.9
Urinary tract	KU1919	9
Urinary tract	RT11284	8.7
Urinary tract	RT112	8.1
Urinary tract	RT4	9.6
Urinary tract	SCABER	8.4
Urinary tract	SW1710	9.6
Urinary tract	SW780	7.9
Urinary tract	T24	9
Urinary tract	TCCSUP	8
Urinary tract	UMUC1	8.9
Urinary tract	UMUC3	8.6
Urinary tract	VMCUB1	8.2

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	5.9
Adrenal gland	16.4
Appendix	7
Bone marrow	6.1
Breast	13.9
Cerebral cortex	19.5
Cervix, uterine	13.6
Colon	7.3
Duodenum	5.3
Endometrium	10.8
Epididymis	26.5
Esophagus	7.3
Fallopian tube	16.8
Gallbladder	13.2
Heart muscle	4.2
Kidney	10.1
Liver	3.1
Lung	14.5
Lymph node	9.1
Ovary	10.1
Pancreas	1.6
Parathyroid gland	11.1
Placenta	7.5
Prostate	11.1
Rectum	9.8
Salivary gland	2.1
Seminal vesicle	7.6
Skeletal muscle	4
Skin	6.8
Small intestine	5.7
Smooth muscle	9.8
Spleen	8
Stomach	6.4
Testis	16.2
Thyroid gland	26.9
Tonsil	7.3
Urinary bladder	11.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28024138	overexpression	Ovarian Carcinoma	SMYD3 mRNA and protein expressions were higher in the patients carrying genotype 3/3 than they were in the patients with the 2/2+2/3 genotype (all P<0.05).
27554136	overexpression	Liver Neuroendocrine Tumor	Smyd3 expression has a high discriminative power for the characterization of liver tumors and positively correlates with poor prognosis.
27569210	Overexpression	Breast Carcinoma	SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation. Our findings suggest that SMYD3-mediated H2A.Z.1K101 dimethylation activates cyclin A1 expression and contributes to driving the proliferation of breast cancer cells.
27554136	Overexpression	Hepatocellular Carcinoma; Colon Carcinoma; Lung Carcinoma; Pancreatic Carcinoma	SMYD3 is a member of the SET and MYND-domain family of methyl-transferases, the increased expression of which correlates with poor prognosis in various types of cancer. In liver and colon tumors, SMYD3 is localized in the nucleus, where it interacts with RNA Pol II and H3K4me3 and functions as a selective transcriptional amplifier of oncogenes and genes that control cell proliferation and metastatic spread. In lung and pancreatic cancer, SMYD3 acts in the cytoplasm, potentiating oncogenic Ras/ERK signaling through the methylation of the MAP3K2 kinase and the subsequent release from its inhibitor.
27066749	Overexpression	Colorectal Carcinoma; Breast Carcinoma; Prostate Carcinoma; Hepatocellular Carcinoma	SMYD3 is a lysine methyltransferase overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies.
26980013	Overexpression	Esophageal Squamous Cell Carcinoma	Increased expression of SMYD3 was found to be associated with lymph node metastasis in ESCC (P = .036) and was an independent prognostic factor for poor overall survival (P = .025).
26790435	Overexpression	Chronic Lymphocytic Leukemia	We found that SMYD2 and SMYD3 are overexpressed in CLL patients and, interestingly, patients with residual expression of both genes presented a high WBC count and complex karyotype.
26328527	Overexpression	Gastric Carcinoma; Breast Carcinoma; Glioma	SMYD3 activates the transcription of oncogenes and cell cycle genes in gastric and breast cancer cells. We found that SMYD3 was overexpressed in human glioma but not in normal brain tissue.
26077602	Overexpression	Gastric Carcinoma	The messenger RNA and protein expression levels of SMYD3 and TGF-β1 in GC tissues were significantly higher than those in adjacent nontumor tissues. High expression levels of SMYD3 and TGF-β1 can indicate poor prognoses for GC patients.
25728514	Overexpression	Colorectal Carcinoma	We studied the expression and activity of SMYD3 in a preclinical model of colorectal cancer (CRC) and found that it is strongly upregulated throughout tumorigenesis both at the mRNA and protein level.
25627005	Overexpression	Gastric Carcinoma	Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patients with gastric cancer. The messenger RNA (mRNA) and protein expression levels of SMYD3 and MMP-9 in gastric cancer tissues were both significantly higher than those in adjacent nontumor tissues.
25472580	Overexpression	Gastric Carcinoma	SMYD3 overexpression was a risk factor in the biological behavior and prognosis of gastric carcinoma. SMYD3 mRNA and protein expression levels were higher in GC cell lines MKN28, SGC7901, and MGC803 than normal gastric mucosa cell line GES-1.
25471787	Overexpression	Gastric Carcinoma	Overexpression of SMYD3 was associated with increased STAT3 activation in gastric cancer. The mRNA expression levels of SMYD3 or STAT3 and the protein expression levels of SMYD3, STAT3, or pSTAT3 in GC tissues were significantly higher than those in adjacent non-tumor tissues. High SMYD3 and pSTAT3 expressions may indicate poor prognosis of patients with GC.
25382779	Overexpression	Pancreatic Intraepithelial Neoplasia	SMYD3 is up-regulated in different types of tumours. Furthermore, depletion of SMYD3 synergises with a MEK inhibitor, currently in clinical trials, to block Ras-driven pancreatic neoplasia.
24200674	Overexpression	Prostate Carcinoma	SMYD3, SUV39H2, PRMT6, KDM5A, and KDM6A were upregulated, whereas KMT2A-E (MLL1-5) and KDM4B were downregulated in PCa, compared with normal prostate tissues.
24189459	Overexpression	Breast Carcinoma	Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells, while contrary results were observed when the endogenous MRTF-A and SMYD3 were suppressed with specific siRNAs.
24174655	Overexpression	Prostate Carcinoma	The upregulation of SMYD3 protein expression was observed in seven of eight prostate tumor specimens, compared with matched normal tissues. SMYD3 promotes prostate tumorigenesis and mediates epigenetic upregulation of AR expression.
23285160	Overexpression	Prostate Carcinoma	In addition, we observed strong SMYD3 expression in the prostate cancer cell line LNCaP and its inhibition led to decreased 15-LOX-1 expression.
22819820	Overexpression	Intrahepatic Cholangiocarcinoma	Over-expression of miR-124 suppressed cell migration and invasion in vitro, and reduced the protein levels of SMYD3 and downstream target genes (c-Myc and MMP9). In conclusion, our studies indicate that low miR-124 levels mediated by HCVc via DNMT1 promote ICC cell migration and invasion by targeting SMYD3.
22406368	Overexpression	Hepatocellular Carcinoma	Expression of H3K4me3 and SMYD3 were enhanced in HCC cell lines.
21450690	Overexpression	Hilar Cholangiocarcinoma	Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells. Transfection of HCVc into hilar cholangiocarcinoma cell lines QBC939 and FRH0201 could upregulate the expression of SMYD3 and promote cell growth, which was consistent with the results of our clinical research.
20957523	Overexpression	Breast Carcinoma	Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells.
20725992	Overexpression	Rectal Carcinoma	Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. The presence of activating KRAS mutations is significantly correlated to an upregulation of 13 genes (adjusted P-value <0.05), among them DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase.
20039369	Overexpression	Breast Carcinoma	We previously reported that overexpression of SMYD3 stimulated the migration of cells.
19509295	Overexpression	Breast Carcinoma	Recent studies showed that SMYD3 is frequently overexpressed in different types of cancer cells, but how SMYD3 regulates the development and progression of these malignancies remains unknown. Thus, our results identify SMYD3 as a new coactivator for ER-mediated transcription, providing a possible link between SMYD3 overexpression and breast cancer.
19403031	Overexpression	Hepatocellular Carcinoma	HBx protein enhanced SMYD3 mRNA and SMYD3 expressions in HepG2.
17998933	Overexpression	Colorectal Carcinoma; Hepatocellular Carcinoma; Breast Carcinoma	We earlier showed that SMYD3, a histone H3-lysine 4-specific methyltransferase, is frequently upregulated in human colorectal, liver and breast cancer compared to their matched non-cancerous cells, and that its activity is associated with the growth of these tumors. In the present study, we found that human cancer cells express both the full-length and a cleaved form of SMYD3 protein.
17963297	Overexpression	Hepatocellular Carcinoma	SMYD3 over-expression in HCC was associated with RIZ1 hypermethylation and mRNA down-expression.
16772086	Overexpression	Hepatocellular Carcinoma	The expression of SMYD3 mRNA was abundant in HCC cell lines HepG2, Hep3B, SMMC7721, whereas none in normal hepatic cell line L-02. SMYD3 plays a major role in occurrence and progress of HCC.
16687068	Overexpression	Hepatocellular Carcinoma	SMYD3 was overexpressed in the HCC cell lines and HCC tissue. SMYD3 is overexpressed in various HCC cell lines and HCC tissue; RNA interference can down-regulate SMYD3 expression, inhibit proliferation and promote apoptosis of HepG2 cells.
16441421	Overexpression	Breast Carcinoma	Enhanced SMYD3 expression is essential for the growth of breast cancer cells. In the present study, we reveal that SMYD3 expression is also elevated in the great majority of breast cancer tissues.
16155568	Overexpression; Mutation	Colorectal Carcinoma; Hepatocellular Carcinoma	We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas. These data suggest that the common variable number of tandem repeats polymorphism in SMYD3 is a susceptibility factor for some types of human cancer.
15235609	Overexpression	Colorectal Carcinoma; Hepatocellular Carcinoma	Here we report the identification of SMYD3, a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas.

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.04	0.422	13.4	52.7	33.9	Gain
BRCA	Breast invasive carcinoma	1075	0.384	4.42e-39	3.3	23	73.7	Gain
CESC	Cervical and endocervical cancers	292	0.108	0.0648	5.5	43.8	50.7	Gain
COAD	Colon adenocarcinoma	449	0.458	1.13e-24	11.1	66.6	22.3	Neutral
ESCA	Esophageal carcinoma	183	0.422	2.6e-09	13.1	38.3	48.6	Gain
GBM	Glioblastoma multiforme	147	0.44	2.44e-08	9.5	74.8	15.6	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.326	3.28e-14	9.9	61.9	28.2	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.363	7.99e-18	8	81.3	10.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.36	3.12e-10	7.6	85.8	6.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.121	0.122	0	97.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.135	0.0021	7	87.1	5.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.505	6.19e-25	2.5	26.4	71.2	Gain
LUAD	Lung adenocarcinoma	512	0.423	1.28e-23	4.7	27.5	67.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.443	2.46e-25	8	40.6	51.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.504	1.02e-20	11	30.7	58.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.277	0.000189	5.1	63.8	31.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.527	5.85e-13	13	73.5	13.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.204	4.95e-06	3.7	90	6.3	Neutral
READ	Rectum adenocarcinoma	164	0.466	3.13e-10	11.6	60.4	28	Neutral
SARC	Sarcoma	255	0.266	1.64e-05	31	50.6	18.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.51	1.2e-25	5.2	39.5	55.3	Gain
STAD	Stomach adenocarcinoma	413	0.444	2.45e-21	8.5	60.5	31	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.378	1.8e-06	4.7	51.3	44	Gain
THCA	Thyroid carcinoma	497	0.247	2.33e-08	0.8	93.2	6	Neutral
THYM	Thymoma	119	0.352	8.51e-05	0	76.5	23.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.464	5.21e-30	3	56.1	41	Gain

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.088	0.0711	17	408	-0.001	0.108	NS/NA
BRCA	Breast invasive carcinoma	-0.194	8.99e-09	83	785	0	0.461	NS/NA
CESC	Cervical and endocervical cancers	-0.208	0.000244	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.187	0.000836	19	297	0.122	0.00373	NS/NA
ESCA	Esophageal carcinoma	-0.192	0.00743	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.31	0.0124	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.192	6.73e-06	20	522	-0.012	0.0721	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.117	0.0298	24	319	0.001	0.0167	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.193	0.000821	23	275	0.001	0.163	NS/NA
LAML	Acute Myeloid Leukemia	-0.037	0.636	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.173	6.18e-05	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.289	2.45e-09	41	373	-0.002	0.00559	NS/NA
LUAD	Lung adenocarcinoma	-0.12	0.00883	21	456	0.001	0.289	NS/NA
LUSC	Lung squamous cell carcinoma	-0.176	0.000617	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.6	0.0968	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.063	0.395	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.232	0.00146	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.046	0.289	35	498	-0.014	2.12e-07	NS/NA
READ	Rectum adenocarcinoma	-0.192	0.0549	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.189	0.00211	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.278	9.67e-10	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.224	1.33e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.351	8.29e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.15	0.000382	50	509	0.007	5.56e-11	NS/NA
THYM	Thymoma	-0.118	0.196	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.283	6.48e-10	34	431	-0.002	0.189	NS/NA

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	1	Low
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	2	Medium
Vagina	3	High

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.731	NS	24476821
BRCA	Breast invasive carcinoma	521	8.82e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00567	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0169	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.77e-13	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	8.19e-06	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.11e-09	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.302	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.000129	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000725	Significant	21720365
PRAD	Prostate adenocarcinoma	333	8.05e-10	Significant	26544944
READ	Rectum adenocarcinoma	67	0.413	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000326	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.000702	Significant	25079317
THCA	Thyroid carcinoma	391	2.68e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.717	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.965	0.867	NS
BRCA	Breast invasive carcinoma	1079	0.902	0.635	NS
CESC	Cervical and endocervical cancers	291	1.201	0.563	NS
COAD	Colon adenocarcinoma	439	0.768	0.35	NS
ESCA	Esophageal carcinoma	184	1.326	0.387	NS
GBM	Glioblastoma multiforme	158	0.677	0.134	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.605	0.0124	Shorter
KIRC	Kidney renal clear cell carcinoma	531	1.128	0.532	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.181	0.0888	NS
LAML	Acute Myeloid Leukemia	149	0.85	0.574	NS
LGG	Brain Lower Grade Glioma	511	0.387	0.000269	Longer
LIHC	Liver hepatocellular carcinoma	365	1.364	0.206	NS
LUAD	Lung adenocarcinoma	502	0.81	0.305	NS
LUSC	Lung squamous cell carcinoma	494	0.8	0.275	NS
OV	Ovarian serous cystadenocarcinoma	303	1.099	0.646	NS
PAAD	Pancreatic adenocarcinoma	177	1.258	0.487	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.862	0.882	NS
PRAD	Prostate adenocarcinoma	497	0.815	0.831	NS
READ	Rectum adenocarcinoma	159	1.252	0.667	NS
SARC	Sarcoma	259	1.699	0.0551	NS
SKCM	Skin Cutaneous Melanoma	459	1.213	0.326	NS
STAD	Stomach adenocarcinoma	388	1.267	0.273	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.332	NS
THCA	Thyroid carcinoma	500	3.949	0.065	NS
THYM	Thymoma	119	1.785	0.501	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.041	0.89	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.005	0.916	NS
BRCA	Breast invasive carcinoma	1071	-0.012	0.685	NS
CESC	Cervical and endocervical cancers	167	-0.011	0.885	NS
COAD	Colon adenocarcinoma	445	0.094	0.0478	Higher
ESCA	Esophageal carcinoma	162	0.118	0.136	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.162	0.000561	Higher
KIRC	Kidney renal clear cell carcinoma	531	-0.014	0.745	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.199	0.00128	Higher
LIHC	Liver hepatocellular carcinoma	347	0.032	0.555	NS
LUAD	Lung adenocarcinoma	507	-0.051	0.248	NS
LUSC	Lung squamous cell carcinoma	497	-0.005	0.92	NS
OV	Ovarian serous cystadenocarcinoma	302	0.009	0.872	NS
PAAD	Pancreatic adenocarcinoma	176	0.073	0.335	NS
READ	Rectum adenocarcinoma	156	0.038	0.635	NS
SKCM	Skin Cutaneous Melanoma	410	-0.071	0.153	NS
STAD	Stomach adenocarcinoma	392	-0.074	0.144	NS
TGCT	Testicular Germ Cell Tumors	81	-0.266	0.0164	Lower
THCA	Thyroid carcinoma	499	0.081	0.0699	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.027	0.55	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.069	0.259	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.188	2.47e-05	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.053	0.222	NS
LGG	Brain Lower Grade Glioma	514	-0.048	0.281	NS
LIHC	Liver hepatocellular carcinoma	366	0.173	0.000916	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.131	0.024	Lower
PAAD	Pancreatic adenocarcinoma	176	0.092	0.226	NS
STAD	Stomach adenocarcinoma	406	-0.128	0.0101	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.065	0.135	NS

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SMYD3.

Summary
Symbol	SMYD3
Name	SET and MYND domain containing 3
Aliases	KMT3E; ZNFN3A1; ZMYND1; zinc finger, MYND domain containing 1; bA74P14.1; SET and MYND domain-containing pro ......
Location	1q44
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27569210	Breast Carcinoma	downstream	Cyclin A1	Positive regulation	Our findings suggest that SMYD3-mediated H2A.Z.1K101 dimethylation activates cyclin A1 expression and contributes to driving the proliferation of breast cancer cells.
27066749	Colorectal Carcinoma; Breast Carcinoma; Prostate Carcinoma; Hepatocellular Carcinoma	upstream	GSK2807	Negative regulation	These insights allowed for the design of GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki= 14nM).
26980013	Esophageal Squamous Cell Carcinoma	downstream	EZR; LOXL2	Positive regulation	SMYD3 stimulates EZR and LOXL2 transcription to enhance proliferation, migration, and invasion in esophageal squamous cell carcinoma.
26676636	Bladder Carcinoma	downstream	BCLAF1	Positive regulation	Mechanically, SMYD3 positively regulates the expression of BCL2-associated transcription factor 1 (BCLAF1). SMYD3 physically interacts with the promoter of BCLAF1 and upregulates its expression by accumulating di- and trimethylation of H3K4 at the BCLAF1 locus.
26077602	Gastric Carcinoma	partner	TGF-β1	Positive correlation	A significantly positive correlation was found between SMYD3 expression and TGF-β1 expression in GC tissues.
25627005	Gastric Carcinoma	partner	MMP-9	Positive correlation	SMYD3 expression and MMP-9 expression in GC tissues were significantly and positively correlated.
25471787	Gastric Carcinoma	partner	STAT3; pSTAT3	Positive correlation	SMYD3 expression and STAT3 or pSTAT3 expressions in GC tissues were significantly and positively correlated.
24189459	Breast Carcinoma	downstream	MYL9	Positive regulation	Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells, while contrary results were observed when the endogenous MRTF-A and SMYD3 were suppressed with specific siRNAs.
24174655	Prostate Carcinoma	downstream	AR	Positive regulation	SMYD3 promotes prostate tumorigenesis and mediates epigenetic upregulation of AR expression.
23285160	Prostate Carcinoma	downstream	15-LOX-1	Positive regulation	In addition, we observed strong SMYD3 expression in the prostate cancer cell line LNCaP and its inhibition led to decreased 15-LOX-1 expression.
22819820	Intrahepatic Cholangiocarcinoma	upstream	miR-124	Negative regulation	Over-expression of miR-124 suppressed cell migration and invasion in vitro, and reduced the protein levels of SMYD3 and downstream target genes (c-Myc and MMP9). In conclusion, our studies indicate that low miR-124 levels mediated by HCVc via DNMT1 promote ICC cell migration and invasion by targeting SMYD3.
20725992	Rectal Carcinoma	upstream	Mutated KRAS	Positive regulation	Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. The presence of activating KRAS mutations is significantly correlated to an upregulation of 13 genes (adjusted P-value <0.05), among them DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase.
20039369	Breast Carcinoma	upstream	HSP90A	Positive regulation	SET and MYND domain-containing protein 3 (SMYD3) is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis, and heat-shock protein HSP90A has been shown to increase the activity of SMYD3.
19403031	Hepatocellular Carcinoma	upstream	HBx	Positive regulation	HBx protein enhanced SMYD3 mRNA and SMYD3 expressions in HepG2.
17963297	Hepatocellular Carcinoma	partner	RIZ1	association	SMYD3 over-expression in HCC was associated with RIZ1 hypermethylation and mRNA down-expression.
16441421	Breast Carcinoma	downstream	WNT10B	Positive regulation	Moreover, we show here that SMYD3 could promote breast carcinogenesis by directly regulating expression of the proto-oncogene WNT10B. We further reveal that the WNT10B gene is a direct transcriptional target activated by SMYD3.
15235609	Colorectal Carcinoma; Hepatocellular Carcinoma	partner	HELZ	Binding	SMYD3 formed a complex with RNA polymerase II through an interaction with the RNA helicase HELZ and transactivated a set of genes that included oncogenes, homeobox genes and genes associated with cell-cycle regulation.
15235609	Colorectal Carcinoma; Hepatocellular Carcinoma	downstream	Nkx2.8	regulation	SMYD3 bound to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8.