CR2Cancer

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00505 HMG (high mobility group) box
PF09011 HMG-box domain
PF03172 HSR domain
PF01342 SAND domain

Function

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	9636146

> Gene Ontology [ TOP ]
Biological Process	GO:0000723 telomere maintenance GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0006611 protein export from nucleus GO:0006913 nucleocytoplasmic transport GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030336 negative regulation of cell migration GO:0032200 telomere organization GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0036337 Fas signaling pathway GO:0040013 negative regulation of locomotion GO:0042770 signal transduction in response to DNA damage GO:0042772 DNA damage response, signal transduction resulting in transcription GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043542 endothelial cell migration GO:0045765 regulation of angiogenesis GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046826 negative regulation of protein export from nucleus GO:0048514 blood vessel morphogenesis GO:0051051 negative regulation of transport GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051224 negative regulation of protein transport GO:0051271 negative regulation of cellular component movement GO:0060249 anatomical structure homeostasis GO:0060333 interferon-gamma-mediated signaling pathway GO:0060337 type I interferon signaling pathway GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0072331 signal transduction by p53 class mediator GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090317 negative regulation of intracellular protein transport GO:0097191 extrinsic apoptotic signaling pathway GO:1901342 regulation of vasculature development GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902044 regulation of Fas signaling pathway GO:1903828 negative regulation of cellular protein localization GO:1904950 negative regulation of establishment of protein localization GO:2000146 negative regulation of cell motility GO:2001233 regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway
Molecular Function	GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0005125 cytokine activity GO:0070087 chromo shadow domain binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0016604 nuclear body GO:0016605 PML body GO:0030870 Mre11 complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3578972	c.2626G>A	p.D876N	Substitution - Missense	Skin
COSM5978540	c.1345+1G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM285278	c.1742C>A	p.P581H	Substitution - Missense	Large_intestine
COSM5611650	c.387C>T	p.V129V	Substitution - coding silent	Adrenal_gland
COSM5032151	c.381C>T	p.S127S	Substitution - coding silent	Oesophagus
COSM1017646	c.683C>T	p.S228L	Substitution - Missense	Endometrium
COSM3578968	c.2259C>T	p.I753I	Substitution - coding silent	Skin
COSM4400209	c.2508T>G	p.Y836*	Substitution - Nonsense	Skin
COSM1692150	c.1241C>T	p.A414V	Substitution - Missense	Skin
COSM4833386	c.1810G>A	p.E604K	Substitution - Missense	Cervix
COSM3838809	c.345G>A	p.K115K	Substitution - coding silent	Breast
COSM1017662	c.1754G>T	p.R585I	Substitution - Missense	Endometrium
COSM1406124	c.10delG	p.G5fs*4	Deletion - Frameshift	Large_intestine
COSM3909815	c.805C>T	p.P269S	Substitution - Missense	Skin
COSM5711895	c.1720+2_1720+3insA	p.?	Unknown	Soft_tissue
COSM1721363	c.2014-9delC	p.?	Unknown	Skin
COSM3838815	c.1863C>A	p.F621L	Substitution - Missense	Breast
COSM4001534	c.1257G>A	p.S419S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM720287	c.862T>C	p.S288P	Substitution - Missense	Lung
COSM1692155	c.2078C>T	p.T693I	Substitution - Missense	Skin
COSM4171146	c.1599_1600+2delAAGT	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM442459	c.2242G>C	p.E748Q	Substitution - Missense	Breast
COSM1406134	c.2275delA	p.K761fs*40	Deletion - Frameshift	Large_intestine
COSM3962513	c.153C>G	p.D51E	Substitution - Missense	Lung
COSM1645016	c.1010T>C	p.V337A	Substitution - Missense	Salivary_gland
COSM1017629	c.92G>A	p.S31N	Substitution - Missense	Endometrium
COSM371393	c.1344A>T	p.R448S	Substitution - Missense	Lung
COSM79061	c.1804C>T	p.Q602*	Substitution - Nonsense	Ovary
COSM3426190	c.2146T>G	p.L716V	Substitution - Missense	Large_intestine
COSM1406130	c.1531G>A	p.A511T	Substitution - Missense	Large_intestine
COSM4583282	c.2025G>C	p.L675L	Substitution - coding silent	Bone
COSM3578971	c.2429C>T	p.T810I	Substitution - Missense	Skin
COSM5632909	c.718C>G	p.Q240E	Substitution - Missense	Oesophagus
COSM4880797	c.156T>A	p.I52I	Substitution - coding silent	Prostate
COSM5950218	c.48T>A	p.C16*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3426185	c.545G>A	p.R182Q	Substitution - Missense	Pancreas
COSM1017652	c.1081G>T	p.E361*	Substitution - Nonsense	Endometrium
COSM5887731	c.1346-6C>T	p.?	Unknown	Upper_aerodigestive_tract
COSM3578963	c.1155C>T	p.F385F	Substitution - coding silent	Skin
COSM5908157	c.53C>T	p.S18L	Substitution - Missense	Skin
COSM3783408	c.1790A>G	p.N597S	Substitution - Missense	Prostate
COSM4092282	c.1110A>G	p.E370E	Substitution - coding silent	Stomach
COSM1017664	c.2613G>T	p.E871D	Substitution - Missense	Endometrium
COSM1752419	c.741C>T	p.S247S	Substitution - coding silent	Urinary_tract
COSM72768	c.406G>A	p.D136N	Substitution - Missense	Large_intestine
COSM379247	c.1261G>A	p.G421R	Substitution - Missense	Lung
COSM5465460	c.2329T>G	p.F777V	Substitution - Missense	Large_intestine
COSM4832998	c.1785T>A	p.D595E	Substitution - Missense	Cervix
COSM4825779	c.2470A>G	p.K824E	Substitution - Missense	Cervix
COSM373641	c.268G>A	p.E90K	Substitution - Missense	Lung
COSM5004161	c.2380C>T	p.L794L	Substitution - coding silent	Testis
COSM4001534	c.1257G>A	p.S419S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM277427	c.2144T>G	p.F715C	Substitution - Missense	Large_intestine
COSM5807879	c.1129C>T	p.Q377*	Substitution - Nonsense	Liver
COSM3972070	c.1725A>G	p.R575R	Substitution - coding silent	Central_nervous_system
COSM1017665	c.2630A>G	p.D877G	Substitution - Missense	Endometrium
COSM397193	c.985G>C	p.E329Q	Substitution - Missense	Lung
COSM4092288	c.1874C>A	p.T625N	Substitution - Missense	Stomach
COSM442456	c.1157G>A	p.R386K	Substitution - Missense	Breast
COSM4808368	c.228G>T	p.E76D	Substitution - Missense	Pancreas
COSM1017631	c.118G>T	p.E40*	Substitution - Nonsense	Endometrium
COSM3782137	c.1571C>A	p.S524Y	Substitution - Missense	Pancreas
COSM1752419	c.741C>T	p.S247S	Substitution - coding silent	Urinary_tract
COSM4729241	c.1193G>C	p.R398T	Substitution - Missense	Large_intestine
COSM1017660	c.1742C>T	p.P581L	Substitution - Missense	Endometrium
COSM4092291	c.2274G>T	p.E758D	Substitution - Missense	Stomach
COSM5943359	c.1720+3delA	p.?	Unknown	Skin
COSM1326361	c.618G>C	p.E206D	Substitution - Missense	Ovary
COSM4788492	c.2236G>A	p.E746K	Substitution - Missense	Liver
COSM4092290	c.1972A>C	p.S658R	Substitution - Missense	Stomach
COSM5941714	c.1483C>T	p.P495S	Substitution - Missense	Skin
COSM4566401	c.366_367GG>AA	p.E123K	Substitution - Missense	Skin
COSM5456950	c.1948G>A	p.G650R	Substitution - Missense	Large_intestine
COSM1306526	c.16G>A	p.G6S	Substitution - Missense	Urinary_tract
COSM4164422	c.1958A>T	p.K653M	Substitution - Missense	Kidney
COSM442458	c.1746G>C	p.L582F	Substitution - Missense	Breast
COSM1159266	c.2334G>T	p.L778L	Substitution - coding silent	Pancreas
COSM5013979	c.782G>C	p.G261A	Substitution - Missense	Kidney
COSM5697531	c.2051A>G	p.K684R	Substitution - Missense	Soft_tissue
COSM3729226	c.800C>T	p.P267L	Substitution - Missense	Stomach
COSM72768	c.406G>A	p.D136N	Substitution - Missense	Ovary
COSM1227188	c.1587C>G	p.H529Q	Substitution - Missense	Large_intestine
COSM5611643	c.1679C>G	p.T560S	Substitution - Missense	Adrenal_gland
COSM4492852	c.404C>T	p.P135L	Substitution - Missense	Skin
COSM3730600	c.1858C>T	p.R620*	Substitution - Nonsense	Stomach
COSM5994433	c.1978C>T	p.R660C	Substitution - Missense	Prostate
COSM4839803	c.921T>G	p.V307V	Substitution - coding silent	Cervix
COSM3578968	c.2259C>T	p.I753I	Substitution - coding silent	Skin
COSM1017640	c.420T>A	p.I140I	Substitution - coding silent	Endometrium
COSM5505795	c.1395_1396insTT	p.E466fs*8	Insertion - Frameshift	Biliary_tract
COSM5783735	c.1600+5G>C	p.?	Unknown	Breast
COSM3426185	c.545G>A	p.R182Q	Substitution - Missense	Stomach
COSM376757	c.574C>G	p.P192A	Substitution - Missense	Lung
COSM1406133	c.2274_2275insA	p.K762fs*21	Insertion - Frameshift	Large_intestine
COSM1326359	c.1884G>C	p.K628N	Substitution - Missense	Ovary
COSM392443	c.44_45delAA	p.E15fs*8	Deletion - Frameshift	Lung
COSM1406124	c.10delG	p.G5fs*4	Deletion - Frameshift	Large_intestine
COSM4428841	c.539C>G	p.S180C	Substitution - Missense	Oesophagus
COSM4092290	c.1972A>C	p.S658R	Substitution - Missense	Stomach
COSM3578966	c.1769C>T	p.P590L	Substitution - Missense	Skin
COSM3048504	c.608G>A	p.G203E	Substitution - Missense	Upper_aerodigestive_tract
COSM1017635	c.242G>A	p.R81H	Substitution - Missense	Endometrium
COSM3719579	c.924G>C	p.E308D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3743640	c.279A>C	p.Q93H	Substitution - Missense	Liver
COSM3578957	c.596C>T	p.P199L	Substitution - Missense	Skin
COSM315517	c.36G>A	p.R12R	Substitution - coding silent	Lung
COSM1406134	c.2275delA	p.K761fs*40	Deletion - Frameshift	Breast
COSM4092279	c.1040C>T	p.A347V	Substitution - Missense	Stomach
COSM1017633	c.236G>A	p.R79H	Substitution - Missense	Endometrium
COSM41113	c.1805A>T	p.Q602L	Substitution - Missense	Central_nervous_system
COSM1017656	c.1292C>A	p.A431D	Substitution - Missense	Endometrium
COSM1017650	c.864C>A	p.S288S	Substitution - coding silent	Endometrium
COSM3426188	c.1046G>T	p.R349I	Substitution - Missense	Large_intestine
COSM5927258	c.1601-4G>A	p.?	Unknown	Skin
COSM4092285	c.1208A>G	p.D403G	Substitution - Missense	Stomach
COSM4764792	c.1922G>A	p.R641K	Substitution - Missense	Stomach
COSM4834067	c.433G>C	p.E145Q	Substitution - Missense	Cervix
COSM3972066	c.745G>A	p.E249K	Substitution - Missense	Stomach
COSM1017637	c.340G>A	p.E114K	Substitution - Missense	Endometrium
COSM5702471	c.1623_1624TA>CT	p.K542*	Substitution - Nonsense	Soft_tissue
COSM5795621	c.1585C>G	p.H529D	Substitution - Missense	Breast
COSM4844718	c.517G>C	p.E173Q	Substitution - Missense	Cervix
COSM3972066	c.745G>A	p.E249K	Substitution - Missense	Central_nervous_system
COSM4092273	c.566C>T	p.S189L	Substitution - Missense	Cervix
COSM3426185	c.545G>A	p.R182Q	Substitution - Missense	Large_intestine
COSM3838812	c.401A>G	p.Y134C	Substitution - Missense	Breast
COSM5458928	c.320A>G	p.Y107C	Substitution - Missense	Large_intestine
COSM1017646	c.683C>T	p.S228L	Substitution - Missense	Large_intestine
COSM1406126	c.275C>A	p.S92Y	Substitution - Missense	Large_intestine
COSM4092292	c.2432C>T	p.A811V	Substitution - Missense	Stomach
COSM5437477	c.476A>G	p.E159G	Substitution - Missense	Oesophagus
COSM1017644	c.544C>T	p.R182*	Substitution - Nonsense	Biliary_tract
COSM4788492	c.2236G>A	p.E746K	Substitution - Missense	Liver
COSM4543707	c.342G>A	p.E114E	Substitution - coding silent	Skin
COSM80561	c.1290G>A	p.K430K	Substitution - coding silent	Ovary
COSM141026	c.793C>T	p.P265S	Substitution - Missense	Upper_aerodigestive_tract
COSM1017658	c.1345C>T	p.R449C	Substitution - Missense	Endometrium
COSM5904161	c.241C>T	p.R81C	Substitution - Missense	Skin
COSM1266518	c.1541T>A	p.M514K	Substitution - Missense	Oesophagus
COSM3962517	c.1675T>C	p.L559L	Substitution - coding silent	Lung
COSM4414904	c.1766-4G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1017633	c.236G>A	p.R79H	Substitution - Missense	Stomach
COSM315517	c.36G>A	p.R12R	Substitution - coding silent	Soft_tissue
COSM3709467	c.1367C>G	p.S456*	Substitution - Nonsense	Liver
COSM3732864	c.2617A>G	p.N873D	Substitution - Missense	Stomach
COSM1736492	c.724G>A	p.A242T	Substitution - Missense	Central_nervous_system
COSM1692153	c.1721G>A	p.G574E	Substitution - Missense	Skin
COSM3578969	c.2289C>T	p.F763F	Substitution - coding silent	Skin
COSM1017644	c.544C>T	p.R182*	Substitution - Nonsense	Endometrium
COSM5917791	c.1450G>A	p.E484K	Substitution - Missense	Skin
COSM1017654	c.1143G>A	p.E381E	Substitution - coding silent	Endometrium
COSM1167660	c.1188_1195+17del25	p.?	Unknown	Skin
COSM3578960	c.787G>A	p.E263K	Substitution - Missense	Skin
COSM4444003	c.282T>A	p.D94E	Substitution - Missense	Large_intestine
COSM1669834	c.194C>A	p.S65*	Substitution - Nonsense	Large_intestine
COSM3578970	c.2396T>C	p.V799A	Substitution - Missense	Skin
COSM1017648	c.755C>T	p.A252V	Substitution - Missense	Endometrium
COSM4390868	c.225C>G	p.L75L	Substitution - coding silent	Breast
COSM1406128	c.1246G>A	p.A416T	Substitution - Missense	Central_nervous_system
COSM1306528	c.275C>T	p.S92F	Substitution - Missense	Urinary_tract
COSM1017642	c.539C>A	p.S180Y	Substitution - Missense	Endometrium
COSM1669834	c.194C>A	p.S65*	Substitution - Nonsense	Large_intestine
COSM1017644	c.544C>T	p.R182*	Substitution - Nonsense	Large_intestine
COSM1406128	c.1246G>A	p.A416T	Substitution - Missense	Large_intestine
COSM3048579	c.2075A>G	p.N692S	Substitution - Missense	Prostate
COSM1017663	c.2242G>T	p.E748*	Substitution - Nonsense	Endometrium
COSM5887731	c.1346-6C>T	p.?	Unknown	Skin
COSM3798731	c.992C>G	p.S331C	Substitution - Missense	Urinary_tract
COSM5711895	c.1720+2_1720+3insA	p.?	Unknown	Upper_aerodigestive_tract
COSM1406135	c.2628T>A	p.D876E	Substitution - Missense	Large_intestine
COSM69161	c.472_474delGAA	p.E158del	Deletion - In frame	Ovary
COSM5943359	c.1720+3delA	p.?	Unknown	Skin
COSM4092276	c.1006G>A	p.D336N	Substitution - Missense	Stomach
COSM3730600	c.1858C>T	p.R620*	Substitution - Nonsense	Stomach
COSM5978540	c.1345+1G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM3838816	c.2378G>A	p.G793D	Substitution - Missense	Breast
COSM1288137	c.2086G>T	p.D696Y	Substitution - Missense	Autonomic_ganglia
COSM3578954	c.239A>T	p.D80V	Substitution - Missense	Skin
COSM3578967	c.2095G>A	p.E699K	Substitution - Missense	Skin
COSM5927256	c.1816C>T	p.P606S	Substitution - Missense	Skin
COSM3736245	c.46T>C	p.C16R	Substitution - Missense	Skin
COSM4729243	c.2629G>A	p.D877N	Substitution - Missense	Large_intestine
COSM5639484	c.482A>G	p.E161G	Substitution - Missense	Oesophagus
COSM3798733	c.2203G>A	p.E735K	Substitution - Missense	Urinary_tract
COSM397716	c.435A>T	p.E145D	Substitution - Missense	Lung
COSM4092273	c.566C>T	p.S189L	Substitution - Missense	Stomach
COSM5498828	c.804G>A	p.L268L	Substitution - coding silent	Biliary_tract
COSM3709467	c.1367C>G	p.S456*	Substitution - Nonsense	Liver
COSM5964935	c.1980C>T	p.R660R	Substitution - coding silent	Breast
COSM4832834	c.1783G>A	p.D595N	Substitution - Missense	Cervix
COSM72768	c.406G>A	p.D136N	Substitution - Missense	Endometrium
COSM1159266	c.2334G>T	p.L778L	Substitution - coding silent	Pancreas
COSM5973649	c.134A>G	p.D45G	Substitution - Missense	Upper_aerodigestive_tract
COSM573880	c.1689C>A	p.N563K	Substitution - Missense	Central_nervous_system
COSM5637256	c.1764A>G	p.R588R	Substitution - coding silent	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for SP100.

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P23497	18	S	Phosphoserine	-	No	None detected
P23497	157	S	Phosphoserine	-	No	None detected
P23497	171	S	Phosphoserine	-	No	None detected
P23497	180	S	Phosphoserine	-	Yes	p.S180Y (cancer: UCEC)
P23497	228	S	Phosphoserine	-	Yes	p.S228L (cancer: UCEC)
P23497	331	S	Phosphoserine	-	Yes	p.S331C (cancer: BLCA)
P23497	362	S	Phosphoserine	-	No	None detected
P23497	394	S	Phosphoserine	-	No	None detected
P23497	407	S	Phosphoserine	-	No	None detected
P23497	409	S	Phosphoserine	-	No	None detected
P23497	410	S	Phosphoserine	-	No	None detected
P23497	451	S	Phosphoserine	-	No	None detected

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.171	6.111	-0.053	0.833	NS
BRCA	Breast invasive carcinoma	112	1100	6.447	6.35	-0.123	0.0477	NS
CESC	Cervical and endocervical cancers	3	306	6.469	6.094	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.147	5.762	-0.409	0.000106	NS
ESCA	Esophageal carcinoma	11	185	6.319	6.292	0.185	0.51	NS
GBM	Glioblastoma multiforme	5	166	3.264	5.534	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.645	6.35	0.726	3.15e-09	Over
KIRC	Kidney renal clear cell carcinoma	72	534	6.131	6.616	0.478	7.54e-23	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.849	6.053	0.181	0.0134	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.402	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.805	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.857	5.722	-0.238	0.0133	NS
LUAD	Lung adenocarcinoma	59	517	6.886	6.478	-0.412	3.4e-08	NS
LUSC	Lung squamous cell carcinoma	51	501	6.913	6.04	-0.941	2.07e-22	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.244	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.73	6.704	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.2	4.821	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.056	5.741	-0.373	8.82e-05	NS
READ	Rectum adenocarcinoma	10	167	6.069	5.656	-0.427	0.0902	NS
SARC	Sarcoma	2	263	5.818	6.149	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	7.084	6.163	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.254	6.537	0.219	0.0648	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.026	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.067	6.451	0.255	1.45e-05	NS
THYM	Thymoma	2	120	6.444	6.285	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.143	5.724	-0.514	0.000529	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	4.6
Autonomic ganglia	CHP212	7.3
Autonomic ganglia	IMR32	4.7
Autonomic ganglia	KELLY	4.6
Autonomic ganglia	KPNRTBM1	4.7
Autonomic ganglia	KPNSI9S	7.9
Autonomic ganglia	KPNYN	4.6
Autonomic ganglia	MHHNB11	4.9
Autonomic ganglia	NB1	4.9
Autonomic ganglia	NH6	5.4
Autonomic ganglia	SHSY5Y	4.5
Autonomic ganglia	SIMA	4.4
Autonomic ganglia	SKNAS	7.2
Autonomic ganglia	SKNBE2	4.5
Autonomic ganglia	SKNDZ	5
Autonomic ganglia	SKNFI	5
Autonomic ganglia	SKNSH	7.5
Biliary tract	HUCCT1	7.6
Biliary tract	HUH28	7.1
Biliary tract	SNU1079	7.5
Biliary tract	SNU1196	6.6
Biliary tract	SNU245	6.2
Biliary tract	SNU308	7
Biliary tract	SNU478	6.9
Bone	143B	7.6
Bone	A673	5.1
Bone	CADOES1	4.8
Bone	CAL78	6.5
Bone	G292CLONEA141B1	6.8
Bone	HOS	7.1
Bone	HS706T	7.6
Bone	HS737T	8.1
Bone	HS819T	8
Bone	HS821T	7.7
Bone	HS822T	8.2
Bone	HS863T	7.9
Bone	HS870T	8.1
Bone	HS888T	7.7
Bone	MG63	7.7
Bone	MHHES1	7.9
Bone	OUMS27	7.9
Bone	RDES	4.9
Bone	SJSA1	7.5
Bone	SKES1	4.9
Bone	SKNMC	4.9
Bone	SW1353	8
Bone	T173	7.9
Bone	TC71	5
Bone	U2OS	6.2
Breast	AU565	6.1
Breast	BT20	6.9
Breast	BT474	6.1
Breast	BT483	5.9
Breast	BT549	6.2
Breast	CAL120	7.1
Breast	CAL148	4.8
Breast	CAL51	5.5
Breast	CAL851	6.7
Breast	CAMA1	5.2
Breast	DU4475	5.6
Breast	EFM192A	5.9
Breast	EFM19	5.3
Breast	EVSAT	5
Breast	HCC1143	7
Breast	HCC1187	6.8
Breast	HCC1395	7.4
Breast	HCC1419	4.7
Breast	HCC1428	5.9
Breast	HCC1500	5.6
Breast	HCC1569	6.4
Breast	HCC1599	5.5
Breast	HCC1806	7
Breast	HCC1937	7.2
Breast	HCC1954	6.7
Breast	HCC202	6.2
Breast	HCC2157	5.8
Breast	HCC2218	5.8
Breast	HCC38	7.1
Breast	HCC70	8
Breast	HDQP1	8.6
Breast	HMC18	5.7
Breast	HS274T	8
Breast	HS281T	8
Breast	HS343T	7.7
Breast	HS578T	6.9
Breast	HS606T	7.9
Breast	HS739T	8.3
Breast	HS742T	8.1
Breast	JIMT1	6.5
Breast	KPL1	5.6
Breast	MCF7	6.2
Breast	MDAMB134VI	5.2
Breast	MDAMB157	7
Breast	MDAMB175VII	6.6
Breast	MDAMB231	7.5
Breast	MDAMB361	6.5
Breast	MDAMB415	7.8
Breast	MDAMB436	7.4
Breast	MDAMB453	5.5
Breast	MDAMB468	7
Breast	SKBR3	5.5
Breast	T47D	5.8
Breast	UACC812	5
Breast	UACC893	5.1
Breast	YMB1	5.5
Breast	ZR751	6.2
Breast	ZR7530	6.5
Central nervous system	1321N1	7.9
Central nervous system	42MGBA	8.1
Central nervous system	8MGBA	8.5
Central nervous system	A172	7.4
Central nervous system	AM38	8.1
Central nervous system	BECKER	8.6
Central nervous system	CAS1	7.6
Central nervous system	CCFSTTG1	7.6
Central nervous system	D283MED	5.3
Central nervous system	D341MED	4.7
Central nervous system	DAOY	6.9
Central nervous system	DBTRG05MG	7
Central nervous system	DKMG	7.4
Central nervous system	GAMG	7.7
Central nervous system	GB1	6.2
Central nervous system	GI1	6.9
Central nervous system	GMS10	8
Central nervous system	GOS3	7.6
Central nervous system	H4	8
Central nervous system	HS683	7.8
Central nervous system	KALS1	7.4
Central nervous system	KG1C	7.9
Central nervous system	KNS42	6.3
Central nervous system	KNS60	7.6
Central nervous system	KNS81	7.9
Central nervous system	KS1	7.6
Central nervous system	LN18	6.6
Central nervous system	LN229	7.7
Central nervous system	M059K	7.2
Central nervous system	MOGGCCM	6.5
Central nervous system	MOGGUVW	8.1
Central nervous system	NMCG1	6.8
Central nervous system	ONS76	6.7
Central nervous system	SF126	7.9
Central nervous system	SF295	7.7
Central nervous system	SNB19	7.1
Central nervous system	SNU1105	7.4
Central nervous system	SNU201	6.8
Central nervous system	SNU466	7.1
Central nervous system	SNU489	7
Central nervous system	SNU626	6.7
Central nervous system	SNU738	6.3
Central nervous system	SW1088	7.9
Central nervous system	SW1783	6.9
Central nervous system	T98G	8
Central nervous system	TM31	6.2
Central nervous system	U118MG	8.1
Central nervous system	U138MG	8.2
Central nervous system	U251MG	7.1
Central nervous system	U87MG	7.7
Central nervous system	YH13	6.5
Central nervous system	YKG1	6.8
Endometrium	AN3CA	6.3
Endometrium	COLO684	4.8
Endometrium	EFE184	7.4
Endometrium	EN	5.2
Endometrium	ESS1	8.5
Endometrium	HEC108	5.5
Endometrium	HEC151	7.1
Endometrium	HEC1A	7
Endometrium	HEC1B	6.6
Endometrium	HEC251	6.9
Endometrium	HEC265	7.1
Endometrium	HEC50B	7.4
Endometrium	HEC59	6.4
Endometrium	HEC6	7.3
Endometrium	ISHIKAWAHERAKLIO02ER	5.1
Endometrium	JHUEM1	6.3
Endometrium	JHUEM2	7.1
Endometrium	JHUEM3	7.4
Endometrium	KLE	6.4
Endometrium	MFE280	5.2
Endometrium	MFE296	6.4
Endometrium	MFE319	5.6
Endometrium	RL952	6.8
Endometrium	SNGM	6.4
Endometrium	SNU1077	7
Endometrium	SNU685	6.8
Endometrium	TEN	6.5
Haematopoietic and lymphoid	697	6.1
Haematopoietic and lymphoid	A3KAW	6.9
Haematopoietic and lymphoid	A4FUK	8.6
Haematopoietic and lymphoid	ALLSIL	7.1
Haematopoietic and lymphoid	AML193	8.3
Haematopoietic and lymphoid	AMO1	6.8
Haematopoietic and lymphoid	BCP1	6
Haematopoietic and lymphoid	BDCM	8.3
Haematopoietic and lymphoid	BL41	7.3
Haematopoietic and lymphoid	BL70	7.5
Haematopoietic and lymphoid	BV173	6.7
Haematopoietic and lymphoid	CA46	6.8
Haematopoietic and lymphoid	CI1	8.2
Haematopoietic and lymphoid	CMK115	7.7
Haematopoietic and lymphoid	CMK86	7.4
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	6.9
Haematopoietic and lymphoid	COLO775	6.5
Haematopoietic and lymphoid	DAUDI	8.3
Haematopoietic and lymphoid	DB	6.7
Haematopoietic and lymphoid	DEL	7.5
Haematopoietic and lymphoid	DND41	7
Haematopoietic and lymphoid	DOHH2	7.4
Haematopoietic and lymphoid	EB1	8.6
Haematopoietic and lymphoid	EB2	8.3
Haematopoietic and lymphoid	EHEB	9.2
Haematopoietic and lymphoid	EJM	7.3
Haematopoietic and lymphoid	EM2	7.1
Haematopoietic and lymphoid	EOL1	7
Haematopoietic and lymphoid	F36P	7.4
Haematopoietic and lymphoid	GA10	7.6
Haematopoietic and lymphoid	GDM1	7.7
Haematopoietic and lymphoid	GRANTA519	7.6
Haematopoietic and lymphoid	HDLM2	7.6
Haematopoietic and lymphoid	HDMYZ	7.9
Haematopoietic and lymphoid	HEL9217	7.4
Haematopoietic and lymphoid	HEL	7.6
Haematopoietic and lymphoid	HH	7.6
Haematopoietic and lymphoid	HL60	7.5
Haematopoietic and lymphoid	HPBALL	6.1
Haematopoietic and lymphoid	HS604T	7.8
Haematopoietic and lymphoid	HS611T	8.7
Haematopoietic and lymphoid	HS616T	8.6
Haematopoietic and lymphoid	HS751T	8.2
Haematopoietic and lymphoid	HT	8.2
Haematopoietic and lymphoid	HTK	7.5
Haematopoietic and lymphoid	HUNS1	8.4
Haematopoietic and lymphoid	HUT102	9.3
Haematopoietic and lymphoid	HUT78	7.1
Haematopoietic and lymphoid	JEKO1	5.5
Haematopoietic and lymphoid	JK1	7.3
Haematopoietic and lymphoid	JM1	6.4
Haematopoietic and lymphoid	JURKAT	6.2
Haematopoietic and lymphoid	JURLMK1	7
Haematopoietic and lymphoid	JVM2	8.7
Haematopoietic and lymphoid	JVM3	8.8
Haematopoietic and lymphoid	K562	6.8
Haematopoietic and lymphoid	KARPAS299	8.2
Haematopoietic and lymphoid	KARPAS422	9
Haematopoietic and lymphoid	KARPAS620	6.7
Haematopoietic and lymphoid	KASUMI1	5.9
Haematopoietic and lymphoid	KASUMI2	6.6
Haematopoietic and lymphoid	KASUMI6	7.4
Haematopoietic and lymphoid	KCL22	7
Haematopoietic and lymphoid	KE37	7
Haematopoietic and lymphoid	KE97	8.3
Haematopoietic and lymphoid	KG1	8.3
Haematopoietic and lymphoid	KHM1B	6.9
Haematopoietic and lymphoid	KIJK	7.9
Haematopoietic and lymphoid	KMH2	7.7
Haematopoietic and lymphoid	KMM1	6.7
Haematopoietic and lymphoid	KMS11	6.7
Haematopoietic and lymphoid	KMS12BM	6.3
Haematopoietic and lymphoid	KMS18	8.4
Haematopoietic and lymphoid	KMS20	6.7
Haematopoietic and lymphoid	KMS21BM	6.8
Haematopoietic and lymphoid	KMS26	7
Haematopoietic and lymphoid	KMS27	7.3
Haematopoietic and lymphoid	KMS28BM	6.5
Haematopoietic and lymphoid	KMS34	6.5
Haematopoietic and lymphoid	KO52	7.9
Haematopoietic and lymphoid	KOPN8	6.7
Haematopoietic and lymphoid	KU812	7
Haematopoietic and lymphoid	KYO1	7.3
Haematopoietic and lymphoid	L1236	7.2
Haematopoietic and lymphoid	L363	6.7
Haematopoietic and lymphoid	L428	7.8
Haematopoietic and lymphoid	L540	8.2
Haematopoietic and lymphoid	LAMA84	7.4
Haematopoietic and lymphoid	LOUCY	7
Haematopoietic and lymphoid	LP1	8.1
Haematopoietic and lymphoid	M07E	7.4
Haematopoietic and lymphoid	MC116	7.7
Haematopoietic and lymphoid	ME1	6.2
Haematopoietic and lymphoid	MEC1	8.9
Haematopoietic and lymphoid	MEC2	9.2
Haematopoietic and lymphoid	MEG01	7.9
Haematopoietic and lymphoid	MHHCALL2	7.2
Haematopoietic and lymphoid	MHHCALL3	7.1
Haematopoietic and lymphoid	MHHCALL4	7.3
Haematopoietic and lymphoid	MINO	4.6
Haematopoietic and lymphoid	MJ	8.1
Haematopoietic and lymphoid	MM1S	6.7
Haematopoietic and lymphoid	MOLM13	7.1
Haematopoietic and lymphoid	MOLM16	6.9
Haematopoietic and lymphoid	MOLM6	7.3
Haematopoietic and lymphoid	MOLP2	7
Haematopoietic and lymphoid	MOLP8	6.8
Haematopoietic and lymphoid	MOLT13	7
Haematopoietic and lymphoid	MOLT16	7.5
Haematopoietic and lymphoid	MOLT4	7
Haematopoietic and lymphoid	MONOMAC1	7
Haematopoietic and lymphoid	MONOMAC6	7.2
Haematopoietic and lymphoid	MOTN1	6.8
Haematopoietic and lymphoid	MUTZ5	7
Haematopoietic and lymphoid	MV411	6.8
Haematopoietic and lymphoid	NALM19	6.8
Haematopoietic and lymphoid	NALM1	6.9
Haematopoietic and lymphoid	NALM6	6.7
Haematopoietic and lymphoid	NAMALWA	7.4
Haematopoietic and lymphoid	NB4	7.4
Haematopoietic and lymphoid	NCIH929	6.9
Haematopoietic and lymphoid	NCO2	7.2
Haematopoietic and lymphoid	NOMO1	7.6
Haematopoietic and lymphoid	NUDHL1	7.1
Haematopoietic and lymphoid	NUDUL1	7.1
Haematopoietic and lymphoid	OCIAML2	7.4
Haematopoietic and lymphoid	OCIAML3	7
Haematopoietic and lymphoid	OCIAML5	7.6
Haematopoietic and lymphoid	OCILY10	8.3
Haematopoietic and lymphoid	OCILY19	6.8
Haematopoietic and lymphoid	OCILY3	8.3
Haematopoietic and lymphoid	OCIM1	7.7
Haematopoietic and lymphoid	OPM2	6.5
Haematopoietic and lymphoid	P12ICHIKAWA	6.5
Haematopoietic and lymphoid	P31FUJ	7.1
Haematopoietic and lymphoid	P3HR1	7.6
Haematopoietic and lymphoid	PCM6	7.3
Haematopoietic and lymphoid	PEER	7.3
Haematopoietic and lymphoid	PF382	6.8
Haematopoietic and lymphoid	PFEIFFER	8
Haematopoietic and lymphoid	PL21	7.6
Haematopoietic and lymphoid	RAJI	7.6
Haematopoietic and lymphoid	RCHACV	6.5
Haematopoietic and lymphoid	REC1	8.3
Haematopoietic and lymphoid	REH	7
Haematopoietic and lymphoid	RI1	7.4
Haematopoietic and lymphoid	RL	7.5
Haematopoietic and lymphoid	RPMI8226	6.2
Haematopoietic and lymphoid	RPMI8402	6.7
Haematopoietic and lymphoid	RS411	7
Haematopoietic and lymphoid	SEM	7.1
Haematopoietic and lymphoid	SET2	7.6
Haematopoietic and lymphoid	SIGM5	7.6
Haematopoietic and lymphoid	SKM1	7.3
Haematopoietic and lymphoid	SKMM2	7.4
Haematopoietic and lymphoid	SR786	7.1
Haematopoietic and lymphoid	ST486	7.2
Haematopoietic and lymphoid	SUDHL10	7.2
Haematopoietic and lymphoid	SUDHL1	6.9
Haematopoietic and lymphoid	SUDHL4	7.5
Haematopoietic and lymphoid	SUDHL5	8.1
Haematopoietic and lymphoid	SUDHL6	8.2
Haematopoietic and lymphoid	SUDHL8	6.1
Haematopoietic and lymphoid	SUPB15	7.2
Haematopoietic and lymphoid	SUPHD1	6.9
Haematopoietic and lymphoid	SUPM2	8
Haematopoietic and lymphoid	SUPT11	7
Haematopoietic and lymphoid	SUPT1	6.4
Haematopoietic and lymphoid	TALL1	7
Haematopoietic and lymphoid	TF1	6.4
Haematopoietic and lymphoid	THP1	7.2
Haematopoietic and lymphoid	TO175T	8.2
Haematopoietic and lymphoid	TOLEDO	7.5
Haematopoietic and lymphoid	U266B1	7
Haematopoietic and lymphoid	U937	7.4
Haematopoietic and lymphoid	UT7	7.2
Haematopoietic and lymphoid	WSUDLCL2	7
Kidney	769P	7.2
Kidney	786O	7.3
Kidney	A498	7.1
Kidney	A704	8.1
Kidney	ACHN	8
Kidney	BFTC909	6.7
Kidney	CAKI1	8
Kidney	CAKI2	6.8
Kidney	CAL54	7.6
Kidney	KMRC1	7.9
Kidney	KMRC20	7.8
Kidney	KMRC2	7.9
Kidney	KMRC3	9.2
Kidney	OSRC2	7.3
Kidney	RCC10RGB	8.3
Kidney	SNU1272	7.8
Kidney	SNU349	7.6
Kidney	TUHR10TKB	8.3
Kidney	TUHR14TKB	6.8
Kidney	TUHR4TKB	7
Kidney	VMRCRCW	7.8
Kidney	VMRCRCZ	7.7
Large intestine	C2BBE1	5.2
Large intestine	CCK81	6.3
Large intestine	CL11	7.2
Large intestine	CL14	6.9
Large intestine	CL34	6.9
Large intestine	CL40	6.9
Large intestine	COLO205	6.9
Large intestine	COLO320	4.8
Large intestine	COLO678	6.4
Large intestine	CW2	7.5
Large intestine	DLD1	7.2
Large intestine	GP2D	6.1
Large intestine	HCC56	6.8
Large intestine	HCT116	6.9
Large intestine	HCT15	6.7
Large intestine	HS675T	7.8
Large intestine	HS698T	8.1
Large intestine	HT115	7.1
Large intestine	HT29	6.9
Large intestine	HT55	7
Large intestine	KM12	6.7
Large intestine	LOVO	7.2
Large intestine	LS1034	7.5
Large intestine	LS123	8.6
Large intestine	LS180	7.1
Large intestine	LS411N	6.7
Large intestine	LS513	6.6
Large intestine	MDST8	8.1
Large intestine	NCIH508	7.6
Large intestine	NCIH716	6.2
Large intestine	NCIH747	7.9
Large intestine	OUMS23	6.2
Large intestine	RCM1	8
Large intestine	RKO	8
Large intestine	SKCO1	7.1
Large intestine	SNU1040	6.4
Large intestine	SNU1197	8.3
Large intestine	SNU175	6.9
Large intestine	SNU283	6.2
Large intestine	SNU407	7
Large intestine	SNU503	6.6
Large intestine	SNU61	7.3
Large intestine	SNU81	7.3
Large intestine	SNUC1	6.2
Large intestine	SNUC2A	7.5
Large intestine	SNUC4	6.7
Large intestine	SNUC5	7.7
Large intestine	SW1116	7.6
Large intestine	SW1417	7.6
Large intestine	SW1463	7.1
Large intestine	SW403	7
Large intestine	SW480	6.5
Large intestine	SW48	6.6
Large intestine	SW620	6.6
Large intestine	SW837	7.9
Large intestine	SW948	7.5
Large intestine	T84	7.7
Liver	ALEXANDERCELLS	6.4
Liver	C3A	5.7
Liver	HEP3B217	6.5
Liver	HEPG2	5.8
Liver	HLE	7.1
Liver	HLF	8
Liver	HUH1	6.3
Liver	HUH6	5.5
Liver	HUH7	6.1
Liver	JHH1	6.4
Liver	JHH2	7.6
Liver	JHH4	8.3
Liver	JHH5	6.7
Liver	JHH6	7.6
Liver	JHH7	5.8
Liver	LI7	6.4
Liver	PLCPRF5	6.6
Liver	SKHEP1	8.6
Liver	SNU182	6.2
Liver	SNU387	8.2
Liver	SNU398	5
Liver	SNU423	7.3
Liver	SNU449	7
Liver	SNU475	7.7
Liver	SNU761	7.6
Liver	SNU878	6.8
Liver	SNU886	7.4
Lung	A549	7
Lung	ABC1	6
Lung	BEN	6.1
Lung	CAL12T	7.2
Lung	CALU1	7.7
Lung	CALU3	7.1
Lung	CALU6	6.6
Lung	CHAGOK1	7.3
Lung	COLO668	6.4
Lung	COLO699	7.1
Lung	CORL105	7.8
Lung	CORL23	7.3
Lung	CORL24	4.8
Lung	CORL279	4.4
Lung	CORL311	4.8
Lung	CORL47	5.2
Lung	CORL51	4.6
Lung	CORL88	4.9
Lung	CORL95	5.7
Lung	CPCN	5
Lung	DMS114	5.2
Lung	DMS153	6
Lung	DMS273	5.6
Lung	DMS454	6.2
Lung	DMS53	5.3
Lung	DMS79	4.5
Lung	DV90	6.9
Lung	EBC1	7.8
Lung	EPLC272H	6.8
Lung	HARA	6.7
Lung	HCC1171	8.1
Lung	HCC1195	5.6
Lung	HCC15	7.6
Lung	HCC2279	8.2
Lung	HCC2935	6.9
Lung	HCC33	4.3
Lung	HCC366	8.8
Lung	HCC4006	8.3
Lung	HCC44	6.8
Lung	HCC78	8.3
Lung	HCC827	7.5
Lung	HCC95	6.8
Lung	HLC1	5.2
Lung	HLFA	7.9
Lung	HS229T	8.1
Lung	HS618T	7.8
Lung	IALM	7.6
Lung	KNS62	6.6
Lung	LC1F	6.3
Lung	LC1SQSF	7.1
Lung	LCLC103H	7.2
Lung	LCLC97TM1	8.1
Lung	LK2	5.3
Lung	LOUNH91	7.6
Lung	LU65	7
Lung	LU99	7
Lung	LUDLU1	6.2
Lung	LXF289	7.3
Lung	MORCPR	6.1
Lung	NCIH1048	6.4
Lung	NCIH1092	4.6
Lung	NCIH1105	5
Lung	NCIH1155	5.3
Lung	NCIH1184	4.7
Lung	NCIH1299	5.8
Lung	NCIH1339	7.7
Lung	NCIH1341	6
Lung	NCIH1355	6.2
Lung	NCIH1373	8.1
Lung	NCIH1385	4.5
Lung	NCIH1395	7.2
Lung	NCIH1435	7
Lung	NCIH1436	4.7
Lung	NCIH1437	6.6
Lung	NCIH146	4.8
Lung	NCIH1563	6.9
Lung	NCIH1568	6.2
Lung	NCIH1573	7.3
Lung	NCIH1581	4.5
Lung	NCIH1618	4.8
Lung	NCIH1623	7.4
Lung	NCIH1648	7.6
Lung	NCIH1650	7.9
Lung	NCIH1651	6.6
Lung	NCIH1666	7.5
Lung	NCIH1693	7.8
Lung	NCIH1694	4.8
Lung	NCIH1703	6.4
Lung	NCIH1734	6.8
Lung	NCIH1755	7.3
Lung	NCIH1781	6.4
Lung	NCIH1792	6.8
Lung	NCIH1793	7.8
Lung	NCIH1836	4.8
Lung	NCIH1838	7.5
Lung	NCIH1869	7.5
Lung	NCIH1876	4.9
Lung	NCIH1915	8
Lung	NCIH1930	4.4
Lung	NCIH1944	6.7
Lung	NCIH1963	4.9
Lung	NCIH196	6.1
Lung	NCIH1975	7
Lung	NCIH2009	7.8
Lung	NCIH2023	7
Lung	NCIH2029	6.5
Lung	NCIH2030	6.9
Lung	NCIH2066	4.9
Lung	NCIH2081	5.1
Lung	NCIH2085	7.3
Lung	NCIH2087	7.5
Lung	NCIH209	4.7
Lung	NCIH2106	4.7
Lung	NCIH2110	7.4
Lung	NCIH211	5
Lung	NCIH2122	6.7
Lung	NCIH2126	7.1
Lung	NCIH2141	4.7
Lung	NCIH2170	6.7
Lung	NCIH2171	5
Lung	NCIH2172	6.3
Lung	NCIH2196	5.5
Lung	NCIH2227	4.6
Lung	NCIH2228	7.5
Lung	NCIH226	8.4
Lung	NCIH2286	7
Lung	NCIH2291	7.7
Lung	NCIH2342	6.4
Lung	NCIH2347	7.2
Lung	NCIH23	4.7
Lung	NCIH2405	7.2
Lung	NCIH2444	6.9
Lung	NCIH292	6.8
Lung	NCIH322	7.7
Lung	NCIH3255	6.8
Lung	NCIH358	7.1
Lung	NCIH441	7.5
Lung	NCIH446	4.6
Lung	NCIH460	7.3
Lung	NCIH510	5.8
Lung	NCIH520	5.4
Lung	NCIH522	5
Lung	NCIH524	4.8
Lung	NCIH526	4.5
Lung	NCIH596	8.4
Lung	NCIH647	7.7
Lung	NCIH650	7.2
Lung	NCIH661	4.6
Lung	NCIH69	4.7
Lung	NCIH727	6.6
Lung	NCIH810	4.5
Lung	NCIH82	4.8
Lung	NCIH838	6.8
Lung	NCIH841	4.8
Lung	NCIH854	6.5
Lung	NCIH889	4.4
Lung	PC14	7.5
Lung	RERFLCAD1	8.3
Lung	RERFLCAD2	8.7
Lung	RERFLCAI	7.1
Lung	RERFLCKJ	7.2
Lung	RERFLCMS	7.6
Lung	RERFLCSQ1	7.5
Lung	SBC5	4.9
Lung	SCLC21H	4.7
Lung	SHP77	5.6
Lung	SKLU1	7.5
Lung	SKMES1	8.4
Lung	SQ1	7
Lung	SW1271	7.6
Lung	SW1573	7
Lung	SW900	7.7
Lung	VMRCLCD	4.9
Lung	VMRCLCP	6.2
Oesophagus	COLO680N	6.5
Oesophagus	ECGI10	6.8
Oesophagus	KYSE140	6.2
Oesophagus	KYSE150	7.5
Oesophagus	KYSE180	6.6
Oesophagus	KYSE270	6.2
Oesophagus	KYSE30	8
Oesophagus	KYSE410	6.6
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	7.2
Oesophagus	KYSE520	7.4
Oesophagus	KYSE70	6
Oesophagus	OE19	6.5
Oesophagus	OE33	7.4
Oesophagus	TE10	6.5
Oesophagus	TE11	7.6
Oesophagus	TE14	6.9
Oesophagus	TE15	7.2
Oesophagus	TE1	6.5
Oesophagus	TE4	6.7
Oesophagus	TE5	6.8
Oesophagus	TE6	6.4
Oesophagus	TE8	6.2
Oesophagus	TE9	6.7
Oesophagus	TT	6.8
Ovary	59M	8
Ovary	A2780	6.2
Ovary	CAOV3	6.7
Ovary	CAOV4	7
Ovary	COLO704	4.9
Ovary	COV318	7.8
Ovary	COV362	7.7
Ovary	COV434	5.1
Ovary	COV504	8
Ovary	COV644	7.1
Ovary	EFO21	7.8
Ovary	EFO27	7
Ovary	ES2	8.1
Ovary	FUOV1	5.4
Ovary	HEYA8	8.5
Ovary	HS571T	8.3
Ovary	IGROV1	6.1
Ovary	JHOC5	7
Ovary	JHOM1	7.3
Ovary	JHOM2B	7.5
Ovary	JHOS2	7.6
Ovary	JHOS4	6.7
Ovary	KURAMOCHI	7
Ovary	MCAS	7.6
Ovary	NIHOVCAR3	6.2
Ovary	OAW28	6.5
Ovary	OAW42	6.2
Ovary	OC314	7
Ovary	OC316	6.9
Ovary	ONCODG1	6
Ovary	OV56	7.6
Ovary	OV7	8.1
Ovary	OV90	6.9
Ovary	OVCAR4	6.2
Ovary	OVCAR8	6.6
Ovary	OVISE	6.9
Ovary	OVK18	5.1
Ovary	OVKATE	7.5
Ovary	OVMANA	7
Ovary	OVSAHO	5.7
Ovary	OVTOKO	6.8
Ovary	RMGI	6.2
Ovary	RMUGS	7.5
Ovary	SKOV3	6.8
Ovary	SNU119	6.3
Ovary	SNU840	7.1
Ovary	SNU8	7.7
Ovary	TOV112D	4.8
Ovary	TOV21G	6.7
Ovary	TYKNU	8.3
Pancreas	ASPC1	7.4
Pancreas	BXPC3	7.8
Pancreas	CAPAN1	7
Pancreas	CAPAN2	7.6
Pancreas	CFPAC1	7.2
Pancreas	DANG	8
Pancreas	HPAC	8.1
Pancreas	HPAFII	8
Pancreas	HS766T	7.4
Pancreas	HUPT3	7.9
Pancreas	HUPT4	7
Pancreas	KCIMOH1	7.9
Pancreas	KLM1	6.2
Pancreas	KP2	7.1
Pancreas	KP3	8
Pancreas	KP4	6.2
Pancreas	L33	6.9
Pancreas	MIAPACA2	7
Pancreas	PANC0203	8
Pancreas	PANC0213	6.9
Pancreas	PANC0327	8.3
Pancreas	PANC0403	7.5
Pancreas	PANC0504	7.8
Pancreas	PANC0813	8.9
Pancreas	PANC1005	7.6
Pancreas	PANC1	6.9
Pancreas	PATU8902	8.4
Pancreas	PATU8988S	7.1
Pancreas	PATU8988T	6.8
Pancreas	PK1	6.9
Pancreas	PK45H	7.6
Pancreas	PK59	7.2
Pancreas	PL45	8.2
Pancreas	PSN1	7.5
Pancreas	QGP1	7
Pancreas	SNU213	7.8
Pancreas	SNU324	7.1
Pancreas	SNU410	7.5
Pancreas	SU8686	7.8
Pancreas	SUIT2	7
Pancreas	SW1990	8.6
Pancreas	T3M4	7.1
Pancreas	TCCPAN2	7.3
Pancreas	YAPC	7.5
Pleura	ACCMESO1	7.7
Pleura	DM3	7.7
Pleura	ISTMES1	8.6
Pleura	ISTMES2	8.2
Pleura	JL1	8
Pleura	MPP89	7.3
Pleura	MSTO211H	8.7
Pleura	NCIH2052	8.1
Pleura	NCIH2452	8.2
Pleura	NCIH28	7
Prostate	22RV1	4.6
Prostate	DU145	7.3
Prostate	LNCAPCLONEFGC	5.9
Prostate	MDAPCA2B	5.6
Prostate	NCIH660	6.5
Prostate	PC3	7
Prostate	VCAP	5.3
Salivary gland	A253	7.3
Salivary gland	YD15	8.1
Skin	A101D	7.7
Skin	A2058	6.6
Skin	A375	6.8
Skin	C32	6.5
Skin	CHL1	6.4
Skin	CJM	7.1
Skin	COLO679	7
Skin	COLO741	6.8
Skin	COLO783	7.8
Skin	COLO792	6.8
Skin	COLO800	7.7
Skin	COLO818	7.7
Skin	COLO829	7.4
Skin	COLO849	7.3
Skin	G361	6.6
Skin	GRM	7.3
Skin	HMCB	6.2
Skin	HS294T	7.3
Skin	HS600T	8.1
Skin	HS688AT	7.7
Skin	HS695T	7.1
Skin	HS839T	7.9
Skin	HS852T	7.2
Skin	HS895T	8.3
Skin	HS934T	7.6
Skin	HS936T	7.1
Skin	HS939T	7.9
Skin	HS940T	8.5
Skin	HS944T	7.2
Skin	HT144	7.8
Skin	IGR1	7.1
Skin	IGR37	6.7
Skin	IGR39	7.7
Skin	IPC298	7.4
Skin	K029AX	7.3
Skin	LOXIMVI	8.4
Skin	MALME3M	6.8
Skin	MDAMB435S	8.2
Skin	MELHO	6.9
Skin	MELJUSO	6.9
Skin	MEWO	7.5
Skin	RPMI7951	8.6
Skin	RVH421	7.5
Skin	SH4	8
Skin	SKMEL1	7.6
Skin	SKMEL24	7.4
Skin	SKMEL28	7.4
Skin	SKMEL2	7.3
Skin	SKMEL30	7.4
Skin	SKMEL31	7.6
Skin	SKMEL3	8.1
Skin	SKMEL5	6.8
Skin	UACC257	7.2
Skin	UACC62	7.3
Skin	WM115	7.4
Skin	WM1799	7
Skin	WM2664	7.4
Skin	WM793	7.7
Skin	WM88	6.9
Skin	WM983B	7.5
Small intestine	HUTU80	5
Soft tissue	A204	7.5
Soft tissue	G401	4.9
Soft tissue	G402	5.7
Soft tissue	GCT	8.4
Soft tissue	HS729	6.9
Soft tissue	HT1080	8.2
Soft tissue	KYM1	6.9
Soft tissue	MESSA	6.9
Soft tissue	RD	7.3
Soft tissue	RH30	6.5
Soft tissue	RH41	4.5
Soft tissue	RKN	7.3
Soft tissue	S117	6.9
Soft tissue	SJRH30	5.1
Soft tissue	SKLMS1	8.2
Soft tissue	SKUT1	7.4
Soft tissue	TE125T	8.2
Soft tissue	TE159T	7.8
Soft tissue	TE441T	5
Soft tissue	TE617T	4.7
Stomach	2313287	6.6
Stomach	AGS	7.4
Stomach	AZ521	4.7
Stomach	ECC10	4.5
Stomach	ECC12	4.5
Stomach	FU97	5.6
Stomach	GCIY	6.5
Stomach	GSS	6
Stomach	GSU	7.1
Stomach	HGC27	5.8
Stomach	HS746T	7.6
Stomach	HUG1N	6.6
Stomach	IM95	6.7
Stomach	KATOIII	6.7
Stomach	KE39	7.3
Stomach	LMSU	8.1
Stomach	MKN1	7
Stomach	MKN45	7.2
Stomach	MKN74	9.3
Stomach	MKN7	7.9
Stomach	NCCSTCK140	7
Stomach	NCIN87	7.5
Stomach	NUGC2	7.9
Stomach	NUGC3	7.4
Stomach	NUGC4	7.8
Stomach	OCUM1	6.7
Stomach	RERFGC1B	6.2
Stomach	SH10TC	7.4
Stomach	SNU16	6.7
Stomach	SNU1	6.6
Stomach	SNU216	7.7
Stomach	SNU520	7.4
Stomach	SNU5	7.3
Stomach	SNU601	7.4
Stomach	SNU620	7.5
Stomach	SNU668	7.1
Stomach	SNU719	6.7
Stomach	TGBC11TKB	8.4
Thyroid	8305C	7.3
Thyroid	8505C	7.5
Thyroid	BCPAP	6.7
Thyroid	BHT101	7.7
Thyroid	CAL62	6.7
Thyroid	CGTHW1	7.1
Thyroid	FTC133	6.8
Thyroid	FTC238	7.3
Thyroid	ML1	7.2
Thyroid	SW579	7.6
Thyroid	TT2609C02	7.7
Thyroid	TT	5.9
Upper aerodigestive tract	BHY	6.6
Upper aerodigestive tract	BICR16	6.7
Upper aerodigestive tract	BICR18	7.2
Upper aerodigestive tract	BICR22	7.7
Upper aerodigestive tract	BICR31	7.7
Upper aerodigestive tract	BICR56	7.8
Upper aerodigestive tract	BICR6	7.2
Upper aerodigestive tract	CAL27	7.7
Upper aerodigestive tract	CAL33	7.2
Upper aerodigestive tract	DETROIT562	7.3
Upper aerodigestive tract	FADU	7.3
Upper aerodigestive tract	HS840T	7.9
Upper aerodigestive tract	HSC2	7.5
Upper aerodigestive tract	HSC3	7.6
Upper aerodigestive tract	HSC4	7.9
Upper aerodigestive tract	PECAPJ15	8
Upper aerodigestive tract	PECAPJ34CLONEC12	8.3
Upper aerodigestive tract	PECAPJ41CLONED2	8.8
Upper aerodigestive tract	PECAPJ49	7.8
Upper aerodigestive tract	SCC15	7.9
Upper aerodigestive tract	SCC25	8.4
Upper aerodigestive tract	SCC4	7.5
Upper aerodigestive tract	SCC9	7
Upper aerodigestive tract	SNU1076	8.1
Upper aerodigestive tract	SNU1214	7.4
Upper aerodigestive tract	SNU46	6.8
Upper aerodigestive tract	SNU899	7.3
Upper aerodigestive tract	YD10B	8.7
Upper aerodigestive tract	YD38	7.4
Upper aerodigestive tract	YD8	7.9
Urinary tract	5637	7.1
Urinary tract	639V	6.5
Urinary tract	647V	6.7
Urinary tract	BC3C	6.6
Urinary tract	BFTC905	6.9
Urinary tract	CAL29	7
Urinary tract	HS172T	7.3
Urinary tract	HT1197	8.9
Urinary tract	HT1376	7.2
Urinary tract	J82	7
Urinary tract	JMSU1	7.1
Urinary tract	KMBC2	7.1
Urinary tract	KU1919	6.7
Urinary tract	RT11284	7.5
Urinary tract	RT112	7.4
Urinary tract	RT4	7.4
Urinary tract	SCABER	8.4
Urinary tract	SW1710	7.2
Urinary tract	SW780	7.8
Urinary tract	T24	7.3
Urinary tract	TCCSUP	6.6
Urinary tract	UMUC1	7.3
Urinary tract	UMUC3	7.8
Urinary tract	VMCUB1	6.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	58.7
Adrenal gland	61.7
Appendix	113.3
Bone marrow	139.9
Breast	54.9
Cerebral cortex	14.1
Cervix, uterine	61.8
Colon	41.8
Duodenum	54.4
Endometrium	63.7
Epididymis	41.6
Esophagus	38.2
Fallopian tube	63.7
Gallbladder	104.3
Heart muscle	37.2
Kidney	41.1
Liver	35.2
Lung	102.2
Lymph node	138.1
Ovary	59.8
Pancreas	9.6
Parathyroid gland	11.3
Placenta	87.1
Prostate	63.6
Rectum	46.4
Salivary gland	35.7
Seminal vesicle	50.8
Skeletal muscle	7.1
Skin	39.5
Small intestine	62.2
Smooth muscle	63.7
Spleen	135.1
Stomach	51.9
Testis	20.6
Thyroid gland	59.5
Tonsil	94.6
Urinary bladder	80.9

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.535	2.58e-31	49.3	46.5	4.2	Loss
BRCA	Breast invasive carcinoma	1075	0.303	2.67e-24	27.2	66.5	6.3	Neutral
CESC	Cervical and endocervical cancers	292	0.351	6.97e-10	42.5	54.1	3.4	Loss
COAD	Colon adenocarcinoma	449	0.213	5.53e-06	4.2	76.8	18.9	Neutral
ESCA	Esophageal carcinoma	183	0.381	9.99e-08	24	56.8	19.1	Neutral
GBM	Glioblastoma multiforme	147	0.271	0.000916	6.8	88.4	4.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.457	7.71e-28	29.8	62.8	7.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.357	3.33e-17	8.8	77.5	13.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.367	1.26e-10	4.2	80.2	15.6	Neutral
LAML	Acute Myeloid Leukemia	166	-0.023	0.766	0.6	99.4	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.025	0.569	8.8	88.9	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.206	7.66e-05	14.6	73.6	11.8	Neutral
LUAD	Lung adenocarcinoma	512	0.246	1.74e-08	10.4	64.1	25.6	Neutral
LUSC	Lung squamous cell carcinoma	498	0.492	9.43e-32	30.5	53.8	15.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.141	0.0142	27.3	46	26.7	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.381	1.62e-07	2.8	84.2	13	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.166	0.0352	8.6	90.1	1.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.112	0.0129	5.9	92.3	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.307	6.55e-05	4.9	68.9	26.2	Neutral
SARC	Sarcoma	255	0.407	1.33e-11	39.6	52.5	7.8	Loss
SKCM	Skin Cutaneous Melanoma	367	0.2	0.000114	19.6	62.4	18	Neutral
STAD	Stomach adenocarcinoma	413	0.16	0.00111	12.3	71.9	15.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.022	0.786	7.3	68	24.7	Neutral
THCA	Thyroid carcinoma	497	0.381	1.39e-18	2.4	97.4	0.2	Neutral
THYM	Thymoma	119	0.219	0.0165	4.2	95.8	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.115	0.00782	7.8	78	14.2	Neutral

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.239	7.02e-07	17	408	-0.01	0.0272	NS/NA
BRCA	Breast invasive carcinoma	-0.304	5.04e-20	83	785	0.02	1.51e-15	NS/NA
CESC	Cervical and endocervical cancers	-0.248	1.12e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.205	0.000251	19	297	-0.013	0.672	NS/NA
ESCA	Esophageal carcinoma	-0.401	9.22e-09	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.681	0	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.355	1.03e-17	20	522	-0.084	0.000107	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.19	0.000417	24	319	-0.016	0.0903	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.236	4.22e-05	23	275	-0.088	4.26e-07	NS/NA
LAML	Acute Myeloid Leukemia	-0.303	6.47e-05	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.701	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.285	4.03e-09	41	373	0.002	0.00011	NS/NA
LUAD	Lung adenocarcinoma	-0.288	1.77e-10	21	456	0	8.99e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.524	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.717	0.0369	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.29	7.15e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.595	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.594	0	35	498	0.051	9.58e-08	NS/NA
READ	Rectum adenocarcinoma	-0.152	0.129	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.417	2.08e-12	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.498	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.278	5.86e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.433	2.37e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.515	0	50	509	-0.106	3.45e-12	NS/NA
THYM	Thymoma	-0.411	3.24e-06	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.522	0	34	431	0.014	0.00235	NS/NA

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	2	Medium
Breast	1	Low
Bronchus	2	Medium
Caudate	0	Not detected
Cerebellum	1	Low
Cerebral cortex	2	Medium
Cervix, uterine	1	Low
Colon	3	High
Duodenum	3	High
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	0	Not detected
Fallopian tube	1	Low
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	3	High
Parathyroid gland	1	Low
Placenta	3	High
Prostate	1	Low
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	3	High
Smooth muscle	0	Not detected
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	3	High
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	0	Not detected

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.292	NS	24476821
BRCA	Breast invasive carcinoma	521	0.162	NS	23000897
COAD	Colon adenocarcinoma	149	0.000206	Significant	22810696
GBM	Glioblastoma multiforme	157	3.07e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.04e-19	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.327	NS	26536169
LGG	Brain Lower Grade Glioma	513	7.46e-45	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.5e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.45e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	3.38e-11	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00187	Significant	26544944
READ	Rectum adenocarcinoma	67	0.118	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.563	NS	26091043
STAD	Stomach adenocarcinoma	277	2.14e-06	Significant	25079317
THCA	Thyroid carcinoma	391	2.03e-37	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0898	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.658	0.053	NS
BRCA	Breast invasive carcinoma	1079	0.806	0.341	NS
CESC	Cervical and endocervical cancers	291	0.612	0.125	NS
COAD	Colon adenocarcinoma	439	1.242	0.431	NS
ESCA	Esophageal carcinoma	184	1.304	0.408	NS
GBM	Glioblastoma multiforme	158	1.256	0.381	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.344	0.13	NS
KIRC	Kidney renal clear cell carcinoma	531	1.483	0.0605	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.852	0.123	NS
LAML	Acute Myeloid Leukemia	149	2.065	0.0201	Shorter
LGG	Brain Lower Grade Glioma	511	6.34	1.54e-11	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.658	0.0876	NS
LUAD	Lung adenocarcinoma	502	1.466	0.0671	NS
LUSC	Lung squamous cell carcinoma	494	1.286	0.183	NS
OV	Ovarian serous cystadenocarcinoma	303	1.149	0.522	NS
PAAD	Pancreatic adenocarcinoma	177	1.793	0.0562	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.685	0.667	NS
PRAD	Prostate adenocarcinoma	497	0.88	0.891	NS
READ	Rectum adenocarcinoma	159	2.046	0.278	NS
SARC	Sarcoma	259	0.598	0.0513	NS
SKCM	Skin Cutaneous Melanoma	459	0.393	1.95e-06	Longer
STAD	Stomach adenocarcinoma	388	1.183	0.448	NS
TGCT	Testicular Germ Cell Tumors	134	604296638.092	0.154	NS
THCA	Thyroid carcinoma	500	0.541	0.335	NS
THYM	Thymoma	119	4.655	0.0426	Shorter
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.094	0.75	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.08	0.109	NS
BRCA	Breast invasive carcinoma	1071	-0.049	0.108	NS
CESC	Cervical and endocervical cancers	167	-0.032	0.685	NS
COAD	Colon adenocarcinoma	445	-0.042	0.375	NS
ESCA	Esophageal carcinoma	162	-0.051	0.521	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.084	0.0758	NS
KIRC	Kidney renal clear cell carcinoma	531	0.142	0.00101	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.093	0.136	NS
LIHC	Liver hepatocellular carcinoma	347	-0.063	0.245	NS
LUAD	Lung adenocarcinoma	507	0.039	0.381	NS
LUSC	Lung squamous cell carcinoma	497	-0.048	0.286	NS
OV	Ovarian serous cystadenocarcinoma	302	0.043	0.457	NS
PAAD	Pancreatic adenocarcinoma	176	0.236	0.00159	Higher
READ	Rectum adenocarcinoma	156	0.014	0.859	NS
SKCM	Skin Cutaneous Melanoma	410	-0.029	0.559	NS
STAD	Stomach adenocarcinoma	392	0.078	0.123	NS
TGCT	Testicular Germ Cell Tumors	81	-0.177	0.115	NS
THCA	Thyroid carcinoma	499	0.017	0.703	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.005	0.912	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.131	0.0309	Higher
HNSC	Head and Neck squamous cell carcinoma	498	-0.093	0.0376	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.112	0.0103	Higher
LGG	Brain Lower Grade Glioma	514	0.26	2.08e-09	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.1	0.0565	NS
OV	Ovarian serous cystadenocarcinoma	296	0.074	0.206	NS
PAAD	Pancreatic adenocarcinoma	176	0.217	0.00386	Higher
STAD	Stomach adenocarcinoma	406	0.176	0.000369	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.006	0.891	NS

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SP100.

Summary
Symbol	SP100
Name	SP100 nuclear antigen
Aliases	nuclear antigen Sp100; lysp100b; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; speckl ......
Location	2q37.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for SP100.