CR2Cancer

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain
PF12157 Protein of unknown function (DUF3591)
PF09247 TATA box-binding protein binding

Function

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H1.4ac, H2Aac, H2Bac, H3ac, H4ac	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0006352 DNA-templated transcription, initiation GO:0006354 DNA-templated transcription, elongation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007126 meiotic nuclear division GO:0007140 male meiosis GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0051321 meiotic cell cycle GO:0065004 protein-DNA complex assembly GO:0070897 DNA-templated transcriptional preinitiation complex assembly GO:0071824 protein-DNA complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator GO:1903046 meiotic cell cycle process
Molecular Function	GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding GO:0004402 histone acetyltransferase activity GO:0004674 protein serine/threonine kinase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0017025 TBP-class protein binding GO:0034212 peptide N-acetyltransferase activity GO:0042393 histone binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0070577 lysine-acetylated histone binding
Cellular Component	GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03022 Basal transcription factors
Reactome	R-HSA-1643685: Disease R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167161: HIV Transcription Initiation R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167162: RNA Polymerase II HIV Promoter Escape R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73776: RNA Polymerase II Promoter Escape R-HSA-73857: RNA Polymerase II Transcription R-HSA-75953: RNA Polymerase II Transcription Initiation R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03022 Basal transcription factors

Reactome

R-HSA-1643685: Disease
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-167161: HIV Transcription Initiation
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-167172: Transcription of the HIV genome
R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5912962	c.4108C>T	p.P1370S	Substitution - Missense	Skin
COSM3906834	c.5192A>G	p.K1731R	Substitution - Missense	Stomach
COSM5582708	c.1698C>T	p.V566V	Substitution - coding silent	Skin
COSM290211	c.9C>T	p.P3P	Substitution - coding silent	Large_intestine
COSM4540123	c.2794G>A	p.E932K	Substitution - Missense	Skin
COSM328862	c.5141A>T	p.E1714V	Substitution - Missense	Liver
COSM334934	c.2758G>T	p.A920S	Substitution - Missense	Lung
COSM4752320	c.2672C>T	p.T891M	Substitution - Missense	Breast
COSM298159	c.4664T>A	p.F1555Y	Substitution - Missense	Large_intestine
COSM1462013	c.1939C>T	p.L647F	Substitution - Missense	Large_intestine
COSM1701034	c.3292T>A	p.S1098T	Substitution - Missense	Skin
COSM3930019	c.1184T>C	p.V395A	Substitution - Missense	Central_nervous_system
COSM365912	c.1952G>T	p.G651V	Substitution - Missense	Lung
COSM355325	c.4751G>T	p.R1584L	Substitution - Missense	Skin
COSM347515	c.2590A>T	p.R864W	Substitution - Missense	Lung
COSM2772279	c.1126G>A	p.E376K	Substitution - Missense	Skin
COSM5654816	c.3775A>G	p.K1259E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM346120	c.98G>C	p.G33A	Substitution - Missense	Lung
COSM753638	c.3644G>A	p.R1215H	Substitution - Missense	Lung
COSM1228430	c.365G>T	p.R122I	Substitution - Missense	Large_intestine
COSM3656843	c.3598C>T	p.R1200C	Substitution - Missense	Prostate
COSM4611246	c.4421delA	p.N1474fs*12	Deletion - Frameshift	Large_intestine
COSM216839	c.1873C>G	p.H625D	Substitution - Missense	Pancreas
COSM1701032	c.3772G>A	p.E1258K	Substitution - Missense	Skin
COSM247700	c.4540A>T	p.I1514F	Substitution - Missense	Prostate
COSM1462027	c.10G>A	p.G4S	Substitution - Missense	Large_intestine
COSM3906853	c.3G>A	p.M1I	Substitution - Missense	Stomach
COSM5046511	c.1387A>G	p.N463D	Substitution - Missense	Oesophagus
COSM1132512	c.3029C>T	p.T1010I	Substitution - Missense	Prostate
COSM1108212	c.5087C>A	p.S1696Y	Substitution - Missense	Endometrium
COSM363452	c.2605G>C	p.A869P	Substitution - Missense	Lung
COSM4410724	c.361C>T	p.Q121*	Substitution - Nonsense	Kidney
COSM1243659	c.2584C>T	p.R862W	Substitution - Missense	Oesophagus
COSM4163725	c.1287G>A	p.W429*	Substitution - Nonsense	Thyroid
COSM1108230	c.3218C>A	p.S1073Y	Substitution - Missense	Endometrium
COSM753637	c.3433C>T	p.R1145W	Substitution - Missense	Lung
COSM1228423	c.2836G>T	p.V946F	Substitution - Missense	Large_intestine
COSM4187483	c.3260G>A	p.R1087H	Substitution - Missense	Kidney
COSM753644	c.4352A>G	p.E1451G	Substitution - Missense	Lung
COSM1228429	c.430G>T	p.D144Y	Substitution - Missense	Large_intestine
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Large_intestine
COSM5063885	c.5205A>C	p.P1735P	Substitution - coding silent	Stomach
COSM1108244	c.1823T>C	p.I608T	Substitution - Missense	Endometrium
COSM4410724	c.361C>T	p.Q121*	Substitution - Nonsense	Kidney
COSM1108249	c.993G>A	p.T331T	Substitution - coding silent	Endometrium
COSM5616120	c.5341G>A	p.E1781K	Substitution - Missense	Lung
COSM347387	c.3237G>C	p.E1079D	Substitution - Missense	Lung
COSM753629	c.752C>A	p.P251Q	Substitution - Missense	Lung
COSM5674966	c.3176G>T	p.G1059V	Substitution - Missense	Soft_tissue
COSM5467678	c.407C>T	p.S136L	Substitution - Missense	Large_intestine
COSM1462026	c.113C>T	p.A38V	Substitution - Missense	Large_intestine
COSM226648	c.2662C>T	p.R888C	Substitution - Missense	Skin
COSM1108229	c.3369T>C	p.I1123I	Substitution - coding silent	Endometrium
COSM1581804	c.3746A>G	p.Q1249R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656846	c.3160G>A	p.E1054K	Substitution - Missense	Skin
COSM5785100	c.3022A>G	p.T1008A	Substitution - Missense	Breast
COSM4542107	c.3126G>A	p.W1042*	Substitution - Nonsense	Skin
COSM1462016	c.818C>A	p.S273Y	Substitution - Missense	Large_intestine
COSM1331579	c.1254C>T	p.D418D	Substitution - coding silent	Ovary
COSM4440199	c.3331G>T	p.A1111S	Substitution - Missense	Thyroid
COSM5893414	c.158G>A	p.G53E	Substitution - Missense	Skin
COSM3656873	c.804G>A	p.G268G	Substitution - coding silent	Skin
COSM3779945	c.1806C>T	p.T602T	Substitution - coding silent	Urinary_tract
COSM4163723	c.1293T>C	p.D431D	Substitution - coding silent	Thyroid
COSM1462023	c.127G>A	p.G43S	Substitution - Missense	Large_intestine
COSM164778	c.2263C>T	p.P755S	Substitution - Missense	Breast
COSM385518	c.58A>C	p.M20L	Substitution - Missense	Lung
COSM3848337	c.1879G>A	p.G627R	Substitution - Missense	Breast
COSM4831604	c.2053C>G	p.R685G	Substitution - Missense	Cervix
COSM3656856	c.2355G>A	p.R785R	Substitution - coding silent	Skin
COSM3367459	c.1011G>T	p.E337D	Substitution - Missense	Kidney
COSM455832	c.760C>T	p.R254*	Substitution - Nonsense	Skin
COSM5009751	c.4908T>C	p.D1636D	Substitution - coding silent	Large_intestine
COSM3670407	c.3434G>A	p.R1145Q	Substitution - Missense	Central_nervous_system
COSM21251	c.5472C>A	p.H1824Q	Substitution - Missense	Lung
COSM4801087	c.3941T>C	p.M1314T	Substitution - Missense	Liver
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Large_intestine
COSM1288330	c.4964C>A	p.P1655Q	Substitution - Missense	Autonomic_ganglia
COSM1108225	c.3729G>A	p.R1243R	Substitution - coding silent	Endometrium
COSM2772199	c.4315A>T	p.I1439F	Substitution - Missense	Large_intestine
COSM753638	c.3644G>A	p.R1215H	Substitution - Missense	Large_intestine
COSM3656853	c.2628G>A	p.M876I	Substitution - Missense	Biliary_tract
COSM5761834	c.3237G>A	p.E1079E	Substitution - coding silent	Pancreas
COSM5919760	c.1582C>T	p.L528F	Substitution - Missense	Skin
COSM3656868	c.1215G>A	p.R405R	Substitution - coding silent	Skin
COSM5095174	c.4967T>A	p.M1656K	Substitution - Missense	Thymus
COSM5912962	c.4108C>T	p.P1370S	Substitution - Missense	Skin
COSM251158	c.3782A>T	p.K1261M	Substitution - Missense	Liver
COSM5932504	c.2525G>A	p.R842Q	Substitution - Missense	Skin
COSM1737774	c.4183C>T	p.R1395*	Substitution - Nonsense	Breast
COSM13368	c.2625G>A	p.G875G	Substitution - coding silent	Central_nervous_system
COSM4731989	c.166G>A	p.V56I	Substitution - Missense	Large_intestine
COSM3952653	c.3151A>T	p.M1051L	Substitution - Missense	Lung
COSM247698	c.2777C>G	p.S926C	Substitution - Missense	Prostate
COSM5602392	c.3709G>A	p.E1237K	Substitution - Missense	Skin
COSM5880240	c.4016G>A	p.G1339E	Substitution - Missense	Skin
COSM455833	c.742G>A	p.E248K	Substitution - Missense	Large_intestine
COSM1108226	c.3613C>T	p.R1205*	Substitution - Nonsense	Endometrium
COSM1108243	c.2095C>A	p.L699I	Substitution - Missense	Endometrium
COSM5932502	c.2820G>A	p.M940I	Substitution - Missense	Skin
COSM1173512	c.3293C>T	p.S1098L	Substitution - Missense	Oesophagus
COSM1108218	c.4382G>A	p.R1461Q	Substitution - Missense	Endometrium
COSM352258	c.1600G>C	p.D534H	Substitution - Missense	Lung
COSM3906836	c.4860C>T	p.Y1620Y	Substitution - coding silent	Stomach
COSM3656852	c.2797G>A	p.E933K	Substitution - Missense	Skin
COSM1166416	c.5031G>A	p.T1677T	Substitution - coding silent	Large_intestine
COSM3656842	c.3614G>A	p.R1205Q	Substitution - Missense	Skin
COSM753648	c.5320G>T	p.E1774*	Substitution - Nonsense	Lung
COSM1108233	c.2922T>C	p.D974D	Substitution - coding silent	Endometrium
COSM1267358	c.4799A>C	p.K1600T	Substitution - Missense	Oesophagus
COSM1737676	c.4526G>A	p.R1509H	Substitution - Missense	Large_intestine
COSM1581807	c.2350A>T	p.I784F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656835	c.4428G>A	p.A1476A	Substitution - coding silent	Skin
COSM4565958	c.2777_2778CC>TT	p.S926F	Substitution - Missense	Skin
COSM4482009	c.2566C>T	p.H856Y	Substitution - Missense	Skin
COSM307572	c.1765G>A	p.D589N	Substitution - Missense	Kidney
COSM5790367	c.662A>T	p.E221V	Substitution - Missense	Breast
COSM487371	c.3731G>A	p.R1244Q	Substitution - Missense	Biliary_tract
COSM5600613	c.1792G>A	p.G598S	Substitution - Missense	Skin
COSM51105	c.3786T>G	p.L1262L	Substitution - coding silent	Large_intestine
COSM1701032	c.3772G>A	p.E1258K	Substitution - Missense	Skin
COSM3656867	c.1263C>T	p.F421F	Substitution - coding silent	Skin
COSM5043095	c.2604C>A	p.C868*	Substitution - Nonsense	Liver
COSM1554717	c.1798C>T	p.R600W	Substitution - Missense	Prostate
COSM654	c.3403C>T	p.Q1135*	Substitution - Nonsense	Breast
COSM323724	c.3736A>G	p.I1246V	Substitution - Missense	Lung
COSM3413597	c.400T>C	p.Y134H	Substitution - Missense	Central_nervous_system
COSM4647044	c.3163C>A	p.Q1055K	Substitution - Missense	Large_intestine
COSM4904776	c.3132G>A	p.V1044V	Substitution - coding silent	Skin
COSM5929151	c.2924C>T	p.P975L	Substitution - Missense	Skin
COSM363453	c.1723A>T	p.M575L	Substitution - Missense	Lung
COSM5717478	c.1462C>T	p.P488S	Substitution - Missense	Skin
COSM4440199	c.3331G>T	p.A1111S	Substitution - Missense	Thyroid
COSM1197810	c.5254G>C	p.V1752L	Substitution - Missense	Lung
COSM1636158	c.4049A>G	p.E1350G	Substitution - Missense	Liver
COSM3848334	c.2195G>A	p.G732E	Substitution - Missense	Breast
COSM1108208	c.5286G>T	p.E1762D	Substitution - Missense	Endometrium
COSM608358	c.3239G>A	p.R1080H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1624906	c.773T>C	p.V258A	Substitution - Missense	Liver
COSM21238	c.140G>C	p.G47A	Substitution - Missense	Lung
COSM326625	c.5047G>T	p.V1683L	Substitution - Missense	Lung
COSM1331581	c.1806C>A	p.T602T	Substitution - coding silent	Ovary
COSM3395784	c.1107T>C	p.Y369Y	Substitution - coding silent	Pancreas
COSM1701032	c.3772G>A	p.E1258K	Substitution - Missense	Skin
COSM351875	c.4744C>G	p.Q1582E	Substitution - Missense	Lung
COSM5558347	c.2994A>G	p.K998K	Substitution - coding silent	Prostate
COSM3926681	c.4669C>T	p.P1557S	Substitution - Missense	Skin
COSM5721302	c.4374C>T	p.Y1458Y	Substitution - coding silent	Skin
COSM12965	c.129C>T	p.G43G	Substitution - coding silent	Lung
COSM1108231	c.3191G>T	p.S1064I	Substitution - Missense	Endometrium
COSM5817179	c.3527A>C	p.K1176T	Substitution - Missense	Liver
COSM4407839	c.3763C>T	p.R1255W	Substitution - Missense	Pancreas
COSM1462000	c.4066C>T	p.R1356C	Substitution - Missense	Large_intestine
COSM3656832	c.4906G>A	p.D1636N	Substitution - Missense	Skin
COSM5884847	c.664T>C	p.S222P	Substitution - Missense	Soft_tissue
COSM290211	c.9C>T	p.P3P	Substitution - coding silent	Large_intestine
COSM5600613	c.1792G>A	p.G598S	Substitution - Missense	Skin
COSM3656880	c.395C>T	p.P132L	Substitution - Missense	Skin
COSM753626	c.27G>A	p.L9L	Substitution - coding silent	Lung
COSM5616121	c.258G>C	p.L86F	Substitution - Missense	Lung
COSM1108227	c.3552C>T	p.L1184L	Substitution - coding silent	Endometrium
COSM1462020	c.270C>T	p.G90G	Substitution - coding silent	Large_intestine
COSM5805114	c.1737A>C	p.E579D	Substitution - Missense	Liver
COSM21251	c.5472C>A	p.H1824Q	Substitution - Missense	Lung
COSM1132511	c.2605G>A	p.A869T	Substitution - Missense	Large_intestine
COSM3413590	c.5018C>G	p.T1673R	Substitution - Missense	Central_nervous_system
COSM5926701	c.803G>A	p.G268E	Substitution - Missense	Skin
COSM3906846	c.2468G>A	p.R823Q	Substitution - Missense	Stomach
COSM2772176	c.5337C>T	p.D1779D	Substitution - coding silent	Prostate
COSM1108253	c.422A>G	p.D141G	Substitution - Missense	Endometrium
COSM3848330	c.3643C>T	p.R1215C	Substitution - Missense	Breast
COSM277586	c.2534G>A	p.R845Q	Substitution - Missense	Skin
COSM5721303	c.3585G>C	p.G1195G	Substitution - coding silent	Skin
COSM5721302	c.4374C>T	p.Y1458Y	Substitution - coding silent	Skin
COSM1554706	c.189G>A	p.K63K	Substitution - coding silent	Large_intestine
COSM3656833	c.4768G>A	p.D1590N	Substitution - Missense	Skin
COSM4435973	c.4601T>C	p.V1534A	Substitution - Missense	Oesophagus
COSM1108215	c.4722G>T	p.K1574N	Substitution - Missense	Endometrium
COSM3656850	c.2814C>T	p.F938F	Substitution - coding silent	Skin
COSM5721302	c.4374C>T	p.Y1458Y	Substitution - coding silent	Skin
COSM1132511	c.2605G>A	p.A869T	Substitution - Missense	Prostate
COSM357430	c.3239G>T	p.R1080L	Substitution - Missense	Lung
COSM5602392	c.3709G>A	p.E1237K	Substitution - Missense	Skin
COSM3656868	c.1215G>A	p.R405R	Substitution - coding silent	Skin
COSM5359720	c.2533C>T	p.R845*	Substitution - Nonsense	Large_intestine
COSM1108216	c.4659G>T	p.K1553N	Substitution - Missense	Endometrium
COSM753636	c.3403C>G	p.Q1135E	Substitution - Missense	Breast
COSM247701	c.778C>A	p.R260S	Substitution - Missense	Prostate
COSM4797226	c.3447G>A	p.R1149R	Substitution - coding silent	Liver
COSM5721303	c.3585G>C	p.G1195G	Substitution - coding silent	Skin
COSM5040605	c.2290A>T	p.N764Y	Substitution - Missense	Liver
COSM3926684	c.1747C>T	p.P583S	Substitution - Missense	Skin
COSM1674452	c.1597C>T	p.P533S	Substitution - Missense	Skin
COSM455829	c.2345T>A	p.L782Q	Substitution - Missense	Breast
COSM3413594	c.3238C>T	p.R1080C	Substitution - Missense	Central_nervous_system
COSM4955859	c.695C>A	p.A232D	Substitution - Missense	Liver
COSM753632	c.2029G>C	p.G677R	Substitution - Missense	Lung
COSM1108245	c.1673G>A	p.R558Q	Substitution - Missense	Endometrium
COSM3669943	c.4399C>T	p.H1467Y	Substitution - Missense	Liver
COSM4900967	c.3668A>T	p.K1223I	Substitution - Missense	Skin
COSM403876	c.3113A>C	p.K1038T	Substitution - Missense	Biliary_tract
COSM608354	c.2839C>T	p.H947Y	Substitution - Missense	Skin
COSM5666225	c.922A>T	p.K308*	Substitution - Nonsense	Soft_tissue
COSM5575883	c.4661A>C	p.K1554T	Substitution - Missense	Stomach
COSM3926686	c.926C>T	p.S309F	Substitution - Missense	Skin
COSM258130	c.3659A>C	p.K1220T	Substitution - Missense	Large_intestine
COSM4771379	c.4175C>A	p.S1392Y	Substitution - Missense	Pleura
COSM1624904	c.3624T>C	p.A1208A	Substitution - coding silent	Liver
COSM3906851	c.979G>A	p.D327N	Substitution - Missense	Stomach
COSM3848338	c.168C>A	p.V56V	Substitution - coding silent	Breast
COSM5896027	c.3439G>A	p.E1147K	Substitution - Missense	Skin
COSM2772208	c.4032C>T	p.F1344F	Substitution - coding silent	Stomach
COSM4163722	c.3288G>A	p.L1096L	Substitution - coding silent	Thyroid
COSM20740	c.1897C>T	p.Q633*	Substitution - Nonsense	Ovary
COSM3656867	c.1263C>T	p.F421F	Substitution - coding silent	Skin
COSM21251	c.5472C>A	p.H1824Q	Substitution - Missense	Lung
COSM4752319	c.4274A>G	p.H1425R	Substitution - Missense	Stomach
COSM4401484	c.5244G>A	p.E1748E	Substitution - coding silent	Skin
COSM3656840	c.3843G>A	p.L1281L	Substitution - coding silent	Liver
COSM390327	c.3166G>T	p.A1056S	Substitution - Missense	Lung
COSM3656870	c.1004C>T	p.P335L	Substitution - Missense	Skin
COSM4731981	c.3827G>C	p.R1276P	Substitution - Missense	Large_intestine
COSM5410985	c.1308T>C	p.D436D	Substitution - coding silent	Skin
COSM4960835	c.3182G>A	p.G1061E	Substitution - Missense	Liver
COSM3656838	c.4204G>A	p.V1402M	Substitution - Missense	Skin
COSM5153054	c.5473G>T	p.G1825*	Substitution - Nonsense	Soft_tissue
COSM4731982	c.3792T>C	p.G1264G	Substitution - coding silent	Large_intestine
COSM5359208	c.268G>A	p.G90S	Substitution - Missense	Large_intestine
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Ovary
COSM455833	c.742G>A	p.E248K	Substitution - Missense	Large_intestine
COSM5929150	c.4279C>T	p.P1427S	Substitution - Missense	Skin
COSM5908956	c.4580C>T	p.S1527F	Substitution - Missense	Skin
COSM1462023	c.127G>A	p.G43S	Substitution - Missense	Large_intestine
COSM21238	c.140G>C	p.G47A	Substitution - Missense	Lung
COSM12929	c.2154G>A	p.K718K	Substitution - coding silent	Lung
COSM2772279	c.1126G>A	p.E376K	Substitution - Missense	Large_intestine
COSM5045444	c.1113G>A	p.M371I	Substitution - Missense	Oesophagus
COSM3670406	c.4389G>A	p.E1463E	Substitution - coding silent	Central_nervous_system
COSM3656841	c.3813G>A	p.K1271K	Substitution - coding silent	Skin
COSM378828	c.4081G>T	p.V1361F	Substitution - Missense	Lung
COSM1462007	c.2624G>A	p.G875E	Substitution - Missense	Skin
COSM13367	c.4645C>T	p.H1549Y	Substitution - Missense	Central_nervous_system
COSM3906838	c.4794T>C	p.S1598S	Substitution - coding silent	Stomach
COSM110612	c.689C>T	p.P230L	Substitution - Missense	Skin
COSM753630	c.1192T>C	p.S398P	Substitution - Missense	Lung
COSM5359720	c.2533C>T	p.R845*	Substitution - Nonsense	Large_intestine
COSM3656840	c.3843G>A	p.L1281L	Substitution - coding silent	Liver
COSM185725	c.3727C>T	p.R1243W	Substitution - Missense	Endometrium
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Stomach
COSM3848328	c.4320C>T	p.I1440I	Substitution - coding silent	Pancreas
COSM5717478	c.1462C>T	p.P488S	Substitution - Missense	Skin
COSM1108248	c.1040T>C	p.V347A	Substitution - Missense	Endometrium
COSM3782225	c.1815G>A	p.G605G	Substitution - coding silent	Pancreas
COSM4731987	c.1912C>T	p.P638S	Substitution - Missense	Large_intestine
COSM5664309	c.764C>A	p.P255H	Substitution - Missense	Soft_tissue
COSM5880240	c.4016G>A	p.G1339E	Substitution - Missense	Skin
COSM4795960	c.5098C>T	p.P1700S	Substitution - Missense	Liver
COSM5433959	c.1890A>T	p.K630N	Substitution - Missense	Oesophagus
COSM12930	c.2284C>A	p.L762I	Substitution - Missense	Lung
COSM3930018	c.4888T>C	p.L1630L	Substitution - coding silent	Central_nervous_system
COSM3656862	c.1906C>T	p.R636C	Substitution - Missense	Skin
COSM5998236	c.1526C>T	p.A509V	Substitution - Missense	Prostate
COSM3656847	c.3053C>T	p.S1018F	Substitution - Missense	Skin
COSM4795695	c.5217G>A	p.G1739G	Substitution - coding silent	Liver
COSM5063887	c.1986C>A	p.I662I	Substitution - coding silent	Stomach
COSM1756125	c.118A>G	p.I40V	Substitution - Missense	Urinary_tract
COSM2772262	c.1788A>T	p.Q596H	Substitution - Missense	Stomach
COSM487370	c.4734G>C	p.K1578N	Substitution - Missense	Kidney
COSM285558	c.2089C>A	p.L697I	Substitution - Missense	Large_intestine
COSM5512572	c.396C>A	p.P132P	Substitution - coding silent	Biliary_tract
COSM3906837	c.4796T>G	p.V1599G	Substitution - Missense	Stomach
COSM5672993	c.1791G>A	p.Q597Q	Substitution - coding silent	Soft_tissue
COSM5671909	c.57C>A	p.I19I	Substitution - coding silent	Soft_tissue
COSM393854	c.29G>T	p.R10M	Substitution - Missense	Lung
COSM3943003	c.5424A>G	p.K1808K	Substitution - coding silent	Oesophagus
COSM2772201	c.4266C>G	p.H1422Q	Substitution - Missense	Oesophagus
COSM3906843	c.3113A>G	p.K1038R	Substitution - Missense	Stomach
COSM364828	c.1140G>T	p.G380G	Substitution - coding silent	Lung
COSM3848329	c.3764G>A	p.R1255Q	Substitution - Missense	Breast
COSM5008115	c.4322C>G	p.T1441S	Substitution - Missense	Large_intestine
COSM1108245	c.1673G>A	p.R558Q	Substitution - Missense	Large_intestine
COSM608350	c.2053C>T	p.R685C	Substitution - Missense	Endometrium
COSM1489933	c.2902G>C	p.E968Q	Substitution - Missense	Breast
COSM4949758	c.2059C>A	p.P687T	Substitution - Missense	Liver
COSM4752318	c.4381C>T	p.R1461W	Substitution - Missense	Stomach
COSM3656858	c.2308C>T	p.P770S	Substitution - Missense	Skin
COSM5345779	c.144G>A	p.A48A	Substitution - coding silent	Large_intestine
COSM1701036	c.1345_1346GG>AA	p.G449N	Substitution - Missense	Skin
COSM1108214	c.4924G>T	p.E1642*	Substitution - Nonsense	Endometrium
COSM1108214	c.4924G>T	p.E1642*	Substitution - Nonsense	Skin
COSM285559	c.1097G>A	p.R366Q	Substitution - Missense	Large_intestine
COSM164777	c.3754C>T	p.R1252W	Substitution - Missense	Breast
COSM290707	c.3918G>T	p.V1306V	Substitution - coding silent	Large_intestine
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Biliary_tract
COSM4846259	c.3823G>C	p.E1275Q	Substitution - Missense	Cervix
COSM5552552	c.2390A>G	p.D797G	Substitution - Missense	Prostate
COSM455828	c.2495G>A	p.R832H	Substitution - Missense	Large_intestine
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM4801087	c.3941T>C	p.M1314T	Substitution - Missense	Liver
COSM3656862	c.1906C>T	p.R636C	Substitution - Missense	Biliary_tract
COSM4163724	c.1290G>T	p.E430D	Substitution - Missense	Thyroid
COSM1674452	c.1597C>T	p.P533S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656830	c.5227G>A	p.D1743N	Substitution - Missense	Skin
COSM3656843	c.3598C>T	p.R1200C	Substitution - Missense	Prostate
COSM1132513	c.3200C>T	p.A1067V	Substitution - Missense	Prostate
COSM1288329	c.3363G>T	p.K1121N	Substitution - Missense	Autonomic_ganglia
COSM3656872	c.846G>A	p.R282R	Substitution - coding silent	Skin
COSM40674	c.2894G>A	p.C965Y	Substitution - Missense	Central_nervous_system
COSM1674452	c.1597C>T	p.P533S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3906844	c.2663G>A	p.R888H	Substitution - Missense	Stomach
COSM5472737	c.3406C>A	p.L1136M	Substitution - Missense	Large_intestine
COSM455832	c.760C>T	p.R254*	Substitution - Nonsense	Skin
COSM4848538	c.4158G>C	p.L1386F	Substitution - Missense	Cervix
COSM352256	c.2062C>G	p.Q688E	Substitution - Missense	Lung
COSM1756125	c.118A>G	p.I40V	Substitution - Missense	Urinary_tract
COSM12930	c.2284C>A	p.L762I	Substitution - Missense	Lung
COSM4646231	c.2010A>C	p.E670D	Substitution - Missense	Large_intestine
COSM1462015	c.1318A>G	p.I440V	Substitution - Missense	Large_intestine
COSM346119	c.4150G>T	p.D1384Y	Substitution - Missense	Lung
COSM21039	c.219G>T	p.L73L	Substitution - coding silent	Lung
COSM5998656	c.1832C>A	p.S611*	Substitution - Nonsense	Prostate
COSM85161	c.3325A>G	p.I1109V	Substitution - Missense	Pancreas
COSM13368	c.2625G>A	p.G875G	Substitution - coding silent	Central_nervous_system
COSM5009142	c.3012G>T	p.K1004N	Substitution - Missense	Large_intestine
COSM3724721	c.4236C>A	p.I1412I	Substitution - coding silent	Lung
COSM3413591	c.4999G>A	p.D1667N	Substitution - Missense	Skin
COSM1674452	c.1597C>T	p.P533S	Substitution - Missense	Skin
COSM5941311	c.5375G>A	p.S1792N	Substitution - Missense	Skin
COSM164777	c.3754C>T	p.R1252W	Substitution - Missense	Breast
COSM1108224	c.3755G>A	p.R1252Q	Substitution - Missense	Endometrium
COSM1462012	c.1947G>T	p.Q649H	Substitution - Missense	Large_intestine
COSM1108239	c.2289G>T	p.E763D	Substitution - Missense	Endometrium
COSM1178902	c.3571C>T	p.R1191*	Substitution - Nonsense	Prostate
COSM1462006	c.2772G>T	p.E924D	Substitution - Missense	Large_intestine
COSM3656877	c.578C>T	p.S193F	Substitution - Missense	Skin
COSM4821815	c.5147C>T	p.S1716F	Substitution - Missense	Cervix
COSM6007493	c.4225G>A	p.E1409K	Substitution - Missense	Prostate
COSM3656857	c.2338G>A	p.D780N	Substitution - Missense	Skin
COSM1108223	c.4119G>T	p.K1373N	Substitution - Missense	Endometrium
COSM3656881	c.286G>A	p.D96N	Substitution - Missense	Skin
COSM1228424	c.5437C>A	p.L1813I	Substitution - Missense	Large_intestine
COSM608350	c.2053C>T	p.R685C	Substitution - Missense	Central_nervous_system
COSM1569293	c.2617C>T	p.R873C	Substitution - Missense	Large_intestine
COSM1108220	c.4247G>A	p.R1416K	Substitution - Missense	Endometrium
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM268283	c.2738C>A	p.A913E	Substitution - Missense	Large_intestine
COSM1569293	c.2617C>T	p.R873C	Substitution - Missense	Pancreas
COSM487376	c.358A>G	p.S120G	Substitution - Missense	Kidney
COSM753642	c.3957G>A	p.E1319E	Substitution - coding silent	Lung
COSM3656836	c.4376C>T	p.P1459L	Substitution - Missense	Skin
COSM3906852	c.649G>A	p.A217T	Substitution - Missense	Stomach
COSM455828	c.2495G>A	p.R832H	Substitution - Missense	Breast
COSM3656828	c.5401G>A	p.G1801R	Substitution - Missense	Skin
COSM5410984	c.1882C>T	p.P628S	Substitution - Missense	Skin
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM753628	c.572C>G	p.A191G	Substitution - Missense	Lung
COSM5721303	c.3585G>C	p.G1195G	Substitution - coding silent	Skin
COSM1108217	c.4494A>C	p.E1498D	Substitution - Missense	Endometrium
COSM5904341	c.2843C>T	p.A948V	Substitution - Missense	Skin
COSM1108232	c.2929G>T	p.G977W	Substitution - Missense	Endometrium
COSM5043254	c.745C>A	p.L249I	Substitution - Missense	Liver
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Ovary
COSM1108210	c.5184G>T	p.E1728D	Substitution - Missense	Endometrium
COSM5027057	c.3584G>T	p.G1195V	Substitution - Missense	Breast
COSM4731980	c.4067G>A	p.R1356H	Substitution - Missense	Large_intestine
COSM4407839	c.3763C>T	p.R1255W	Substitution - Missense	Pancreas
COSM4494036	c.4255C>T	p.P1419S	Substitution - Missense	Skin
COSM226648	c.2662C>T	p.R888C	Substitution - Missense	Skin
COSM273327	c.1907G>A	p.R636H	Substitution - Missense	Large_intestine
COSM5063884	c.5441A>G	p.Q1814R	Substitution - Missense	Stomach
COSM487372	c.3145C>T	p.R1049C	Substitution - Missense	Large_intestine
COSM5693881	c.3420G>T	p.W1140C	Substitution - Missense	Soft_tissue
COSM3906845	c.2520G>A	p.R840R	Substitution - coding silent	Stomach
COSM487375	c.585G>C	p.L195F	Substitution - Missense	Kidney
COSM247699	c.4186C>T	p.R1396C	Substitution - Missense	Large_intestine
COSM4999784	c.4548_4549insCC	p.L1517fs*23	Insertion - Frameshift	Pancreas
COSM167572	c.3572G>A	p.R1191Q	Substitution - Missense	Endometrium
COSM108500	c.1306G>A	p.D436N	Substitution - Missense	Skin
COSM5906541	c.2777C>T	p.S926F	Substitution - Missense	Skin
COSM753643	c.4056G>T	p.V1352V	Substitution - coding silent	Lung
COSM5600613	c.1792G>A	p.G598S	Substitution - Missense	Skin
COSM3656847	c.3053C>T	p.S1018F	Substitution - Missense	Skin
COSM753635	c.2785G>T	p.A929S	Substitution - Missense	Lung
COSM5568560	c.1657T>C	p.S553P	Substitution - Missense	Prostate
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM277587	c.2188G>T	p.D730Y	Substitution - Missense	Large_intestine
COSM1108245	c.1673G>A	p.R558Q	Substitution - Missense	Large_intestine
COSM3413595	c.1968A>T	p.Q656H	Substitution - Missense	Central_nervous_system
COSM3952652	c.4349G>A	p.R1450H	Substitution - Missense	Lung
COSM3656875	c.612T>C	p.S204S	Substitution - coding silent	Skin
COSM1730086	c.3688C>T	p.L1230F	Substitution - Missense	Liver
COSM3906841	c.3372G>T	p.E1124D	Substitution - Missense	Stomach
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM3656876	c.600G>A	p.V200V	Substitution - coding silent	Skin
COSM1108247	c.1255G>A	p.E419K	Substitution - Missense	Endometrium
COSM1462018	c.652A>C	p.T218P	Substitution - Missense	Large_intestine
COSM341550	c.5455G>C	p.E1819Q	Substitution - Missense	Lung
COSM1228425	c.4348C>T	p.R1450C	Substitution - Missense	Large_intestine
COSM5912963	c.3707G>A	p.R1236Q	Substitution - Missense	Skin
COSM3656860	c.2130G>A	p.M710I	Substitution - Missense	Skin
COSM4389870	c.2332G>A	p.E778K	Substitution - Missense	Pancreas
COSM1108245	c.1673G>A	p.R558Q	Substitution - Missense	Endometrium
COSM608355	c.3044G>A	p.R1015H	Substitution - Missense	Soft_tissue
COSM3395783	c.4962C>A	p.D1654E	Substitution - Missense	Pancreas
COSM4795960	c.5098C>T	p.P1700S	Substitution - Missense	Liver
COSM403876	c.3113A>C	p.K1038T	Substitution - Missense	Lung
COSM4494506	c.4347C>T	p.L1449L	Substitution - coding silent	Skin
COSM364123	c.148C>T	p.Q50*	Substitution - Nonsense	Lung
COSM3656864	c.1780C>T	p.P594S	Substitution - Missense	Skin
COSM3656872	c.846G>A	p.R282R	Substitution - coding silent	Skin
COSM164777	c.3754C>T	p.R1252W	Substitution - Missense	Kidney
COSM5600613	c.1792G>A	p.G598S	Substitution - Missense	Skin
COSM1314755	c.3079C>T	p.R1027C	Substitution - Missense	Urinary_tract
COSM5558286	c.2512A>T	p.K838*	Substitution - Nonsense	Prostate
COSM5792794	c.518C>G	p.A173G	Substitution - Missense	Breast
COSM4795695	c.5217G>A	p.G1739G	Substitution - coding silent	Liver
COSM1462006	c.2772G>T	p.E924D	Substitution - Missense	Large_intestine
COSM1701031	c.4939G>A	p.E1647K	Substitution - Missense	Skin
COSM3656826	c.5430C>T	p.P1810P	Substitution - coding silent	Skin
COSM5602393	c.4222C>T	p.L1408L	Substitution - coding silent	Skin
COSM5896966	c.4637C>T	p.P1546L	Substitution - Missense	Skin
COSM753641	c.3869G>T	p.G1290V	Substitution - Missense	Lung
COSM1461998	c.4614G>T	p.M1538I	Substitution - Missense	Large_intestine
COSM351876	c.4104G>A	p.Q1368Q	Substitution - coding silent	Lung
COSM3906844	c.2663G>A	p.R888H	Substitution - Missense	Thymus
COSM1108228	c.3496G>T	p.D1166Y	Substitution - Missense	Endometrium
COSM3656842	c.3614G>A	p.R1205Q	Substitution - Missense	Skin
COSM5009669	c.5106A>G	p.K1702K	Substitution - coding silent	Large_intestine
COSM5467677	c.415G>T	p.D139Y	Substitution - Missense	Large_intestine
COSM1228427	c.5455G>T	p.E1819*	Substitution - Nonsense	Large_intestine
COSM5488673	c.5284G>A	p.E1762K	Substitution - Missense	Skin
COSM753627	c.514G>A	p.D172N	Substitution - Missense	Lung
COSM1228426	c.3313G>A	p.D1105N	Substitution - Missense	Large_intestine
COSM2772179	c.5265T>C	p.P1755P	Substitution - coding silent	Large_intestine
COSM5668629	c.3687C>A	p.A1229A	Substitution - coding silent	Soft_tissue
COSM654	c.3403C>T	p.Q1135*	Substitution - Nonsense	Breast
COSM141258	c.410A>T	p.D137V	Substitution - Missense	Upper_aerodigestive_tract
COSM1462017	c.778C>T	p.R260C	Substitution - Missense	Large_intestine
COSM4626425	c.3732G>T	p.R1244R	Substitution - coding silent	Large_intestine
COSM1108207	c.5338G>A	p.E1780K	Substitution - Missense	Stomach
COSM1636157	c.4951G>T	p.E1651*	Substitution - Nonsense	Liver
COSM5926699	c.3250G>A	p.E1084K	Substitution - Missense	Skin
COSM110612	c.689C>T	p.P230L	Substitution - Missense	Skin
COSM5657553	c.4189C>T	p.R1397C	Substitution - Missense	Soft_tissue
COSM4849938	c.478C>T	p.P160S	Substitution - Missense	Cervix
COSM4846080	c.4489G>A	p.D1497N	Substitution - Missense	Cervix
COSM1137989	c.4734_4735GC>CA	p.K1578_H1579>NN	Complex - compound substitution	Kidney
COSM12931	c.2382A>C	p.E794D	Substitution - Missense	Lung
COSM1108247	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM1108254	c.226C>A	p.L76I	Substitution - Missense	Endometrium
COSM1108207	c.5338G>A	p.E1780K	Substitution - Missense	Endometrium
COSM1108246	c.1578G>A	p.E526E	Substitution - coding silent	Endometrium
COSM753646	c.4740G>T	p.K1580N	Substitution - Missense	Lung
COSM5774605	c.4333G>A	p.D1445N	Substitution - Missense	Breast
COSM139783	c.4900G>A	p.E1634K	Substitution - Missense	Skin
COSM1720632	c.1969C>T	p.P657S	Substitution - Missense	Skin
COSM3906849	c.1799G>A	p.R600Q	Substitution - Missense	Stomach
COSM753634	c.2195G>T	p.G732V	Substitution - Missense	Lung
COSM4924396	c.3146G>C	p.R1049P	Substitution - Missense	Liver
COSM3433093	c.2518C>T	p.R840W	Substitution - Missense	Large_intestine
COSM372327	c.1840G>T	p.A614S	Substitution - Missense	Lung
COSM3656845	c.3271C>T	p.L1091L	Substitution - coding silent	Skin
COSM1108238	c.2303G>A	p.R768H	Substitution - Missense	Endometrium
COSM1716991	c.2782T>A	p.F928I	Substitution - Missense	Ovary
COSM5717478	c.1462C>T	p.P488S	Substitution - Missense	Skin
COSM1197810	c.5254G>C	p.V1752L	Substitution - Missense	Lung
COSM4852844	c.1887C>G	p.I629M	Substitution - Missense	Cervix
COSM354681	c.3120_3121CC>AA	p.S1040>?	Complex	Lung
COSM5009570	c.857G>A	p.R286H	Substitution - Missense	Large_intestine
COSM4546889	c.409G>C	p.D137H	Substitution - Missense	Skin
COSM4752320	c.2672C>T	p.T891M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656843	c.3598C>T	p.R1200C	Substitution - Missense	Prostate
COSM277585	c.3276G>T	p.Q1092H	Substitution - Missense	Large_intestine
COSM1108240	c.2281G>C	p.A761P	Substitution - Missense	Endometrium
COSM5595405	c.1628C>T	p.S543F	Substitution - Missense	Skin
COSM1581806	c.2803G>A	p.E935K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656851	c.2806G>A	p.E936K	Substitution - Missense	Skin
COSM1554706	c.189G>A	p.K63K	Substitution - coding silent	Large_intestine
COSM5721302	c.4374C>T	p.Y1458Y	Substitution - coding silent	Skin
COSM3656834	c.4498C>T	p.L1500F	Substitution - Missense	Skin
COSM1108250	c.705G>A	p.M235I	Substitution - Missense	Endometrium
COSM3656839	c.3900C>T	p.L1300L	Substitution - coding silent	Skin
COSM1569293	c.2617C>T	p.R873C	Substitution - Missense	Liver
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM1569293	c.2617C>T	p.R873C	Substitution - Missense	Liver
COSM455827	c.2763C>A	p.G921G	Substitution - coding silent	Breast
COSM12929	c.2154G>A	p.K718K	Substitution - coding silent	Lung
COSM277587	c.2188G>T	p.D730Y	Substitution - Missense	Large_intestine
COSM3656879	c.469C>T	p.P157S	Substitution - Missense	Skin
COSM4466639	c.1445C>T	p.P482L	Substitution - Missense	Skin
COSM3906847	c.2467C>T	p.R823*	Substitution - Nonsense	Stomach
COSM3656848	c.2974A>T	p.T992S	Substitution - Missense	Skin
COSM1267359	c.1803C>T	p.G601G	Substitution - coding silent	Stomach
COSM5779337	c.2808A>C	p.E936D	Substitution - Missense	Breast
COSM1701032	c.3772G>A	p.E1258K	Substitution - Missense	Skin
COSM3656843	c.3598C>T	p.R1200C	Substitution - Missense	Skin
COSM3656865	c.1464C>A	p.P488P	Substitution - coding silent	Skin
COSM4521638	c.1120G>T	p.V374F	Substitution - Missense	Skin
COSM487372	c.3145C>T	p.R1049C	Substitution - Missense	Kidney
COSM5672992	c.5467G>C	p.G1823R	Substitution - Missense	Soft_tissue
COSM5932501	c.4807G>A	p.G1603R	Substitution - Missense	Skin
COSM99018	c.377C>T	p.T126M	Substitution - Missense	Large_intestine
COSM1462011	c.1994_1995insA	p.A666fs*38	Insertion - Frameshift	Large_intestine
COSM1180342	c.4884G>A	p.E1628E	Substitution - coding silent	Prostate
COSM4541977	c.3100G>A	p.E1034K	Substitution - Missense	Skin
COSM455832	c.760C>T	p.R254*	Substitution - Nonsense	Breast
COSM5773163	c.1880G>A	p.G627E	Substitution - Missense	Breast
COSM5966652	c.5083A>G	p.I1695V	Substitution - Missense	Adrenal_gland
COSM3656844	c.3494G>A	p.R1165K	Substitution - Missense	Skin
COSM1108236	c.2470G>T	p.D824Y	Substitution - Missense	Endometrium
COSM1243659	c.2584C>T	p.R862W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4166301	c.1279C>A	p.L427M	Substitution - Missense	Lung
COSM5817367	c.1362C>A	p.G454G	Substitution - coding silent	Liver
COSM331655	c.2930G>A	p.G977E	Substitution - Missense	Lung
COSM1108213	c.4989T>G	p.S1663S	Substitution - coding silent	Endometrium
COSM4836549	c.2289G>A	p.E763E	Substitution - coding silent	Cervix
COSM3656869	c.1177G>A	p.E393K	Substitution - Missense	Skin
COSM3906850	c.1351A>C	p.S451R	Substitution - Missense	Stomach
COSM3723785	c.2895T>G	p.C965W	Substitution - Missense	Upper_aerodigestive_tract
COSM3656857	c.2338G>A	p.D780N	Substitution - Missense	Skin
COSM20740	c.1897C>T	p.Q633*	Substitution - Nonsense	Ovary
COSM5735057	c.3448C>T	p.R1150*	Substitution - Nonsense	Pancreas
COSM1331582	c.3442C>G	p.L1148V	Substitution - Missense	Ovary
COSM285557	c.5076C>A	p.V1692V	Substitution - coding silent	Large_intestine
COSM2772211	c.3927G>A	p.S1309S	Substitution - coding silent	Skin
COSM5903724	c.3031G>A	p.D1011N	Substitution - Missense	Skin
COSM3433094	c.918C>G	p.S306R	Substitution - Missense	Large_intestine
COSM4397423	c.1893C>T	p.I631I	Substitution - coding silent	Skin
COSM4998996	c.1420G>T	p.A474S	Substitution - Missense	Pancreas
COSM4628872	c.1355T>G	p.L452R	Substitution - Missense	Large_intestine
COSM1578599	c.4261A>G	p.T1421A	Substitution - Missense	Meninges
COSM3780735	c.2888G>T	p.G963V	Substitution - Missense	Pancreas
COSM99018	c.377C>T	p.T126M	Substitution - Missense	Stomach
COSM4541977	c.3100G>A	p.E1034K	Substitution - Missense	Skin
COSM5998656	c.1832C>A	p.S611*	Substitution - Nonsense	Prostate
COSM336312	c.1305G>T	p.W435C	Substitution - Missense	Lung
COSM3763884	c.3612C>T	p.V1204V	Substitution - coding silent	Large_intestine
COSM1730776	c.4199C>T	p.P1400L	Substitution - Missense	Liver
COSM1108251	c.585G>A	p.L195L	Substitution - coding silent	Large_intestine
COSM1108241	c.2218G>A	p.E740K	Substitution - Missense	Breast
COSM1581805	c.2992A>T	p.K998*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM455828	c.2495G>A	p.R832H	Substitution - Missense	Breast
COSM1554706	c.189G>A	p.K63K	Substitution - coding silent	Large_intestine
COSM3848329	c.3764G>A	p.R1255Q	Substitution - Missense	Breast
COSM1108242	c.2154G>T	p.K718N	Substitution - Missense	Endometrium
COSM5658581	c.2750T>G	p.L917R	Substitution - Missense	Soft_tissue
COSM3656825	c.5455G>A	p.E1819K	Substitution - Missense	Skin
COSM753639	c.3868G>T	p.G1290*	Substitution - Nonsense	Lung
COSM3656833	c.4768G>A	p.D1590N	Substitution - Missense	Oesophagus
COSM4549737	c.4815G>A	p.E1605E	Substitution - coding silent	Skin
COSM1701035	c.1678C>T	p.L560F	Substitution - Missense	Skin
COSM277586	c.2534G>A	p.R845Q	Substitution - Missense	Skin
COSM3906848	c.1985T>A	p.I662N	Substitution - Missense	Stomach
COSM4839760	c.2335A>C	p.T779P	Substitution - Missense	Cervix
COSM4846353	c.697G>A	p.G233R	Substitution - Missense	Cervix
COSM12965	c.129C>T	p.G43G	Substitution - coding silent	Lung
COSM1108245	c.1673G>A	p.R558Q	Substitution - Missense	Large_intestine
COSM3413591	c.4999G>A	p.D1667N	Substitution - Missense	Central_nervous_system
COSM3996512	c.2268C>T	p.G756G	Substitution - coding silent	Kidney
COSM1569295	c.4109C>T	p.P1370L	Substitution - Missense	Large_intestine
COSM3656827	c.5417G>A	p.R1806K	Substitution - Missense	Skin
COSM3656836	c.4376C>T	p.P1459L	Substitution - Missense	Skin
COSM1331579	c.1254C>T	p.D418D	Substitution - coding silent	Lung
COSM2772258	c.2013A>G	p.Q671Q	Substitution - coding silent	Large_intestine
COSM3656842	c.3614G>A	p.R1205Q	Substitution - Missense	Skin
COSM4403871	c.3128A>C	p.E1043A	Substitution - Missense	Skin
COSM1314756	c.1841C>T	p.A614V	Substitution - Missense	Urinary_tract
COSM4955859	c.695C>A	p.A232D	Substitution - Missense	Liver
COSM5063886	c.2049delT	p.F683fs*27	Deletion - Frameshift	Stomach
COSM389951	c.3897C>T	p.P1299P	Substitution - coding silent	Lung
COSM4451731	c.1378A>G	p.K460E	Substitution - Missense	Skin
COSM5009670	c.4209G>A	p.T1403T	Substitution - coding silent	Large_intestine
COSM3926687	c.68C>T	p.S23L	Substitution - Missense	Skin
COSM4646231	c.2010A>C	p.E670D	Substitution - Missense	Large_intestine
COSM2772206	c.4093C>T	p.P1365S	Substitution - Missense	Skin
COSM108018	c.2349C>T	p.I783I	Substitution - coding silent	Liver
COSM1108211	c.5152G>T	p.V1718L	Substitution - Missense	Endometrium
COSM3656846	c.3160G>A	p.E1054K	Substitution - Missense	Skin
COSM3848330	c.3643C>T	p.R1215C	Substitution - Missense	Thyroid
COSM5600613	c.1792G>A	p.G598S	Substitution - Missense	Skin
COSM4731984	c.2765A>G	p.Y922C	Substitution - Missense	Large_intestine
COSM323726	c.2887G>T	p.G963C	Substitution - Missense	Lung
COSM3656859	c.2302C>T	p.R768C	Substitution - Missense	Skin
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM3848333	c.3412C>T	p.R1138C	Substitution - Missense	Breast
COSM5562530	c.1425C>G	p.P475P	Substitution - coding silent	Prostate
COSM352257	c.1853G>C	p.W618S	Substitution - Missense	Lung
COSM4731986	c.2054G>A	p.R685H	Substitution - Missense	Large_intestine
COSM3848328	c.4320C>T	p.I1440I	Substitution - coding silent	Breast
COSM1177702	c.2776T>C	p.S926P	Substitution - Missense	Endometrium
COSM3656874	c.633G>A	p.E211E	Substitution - coding silent	Skin
COSM1108235	c.2673G>A	p.T891T	Substitution - coding silent	Endometrium
COSM5547352	c.1589delT	p.L530fs*25	Deletion - Frameshift	Prostate
COSM3952657	c.1808T>G	p.F603C	Substitution - Missense	Lung
COSM3906835	c.4992G>A	p.Q1664Q	Substitution - coding silent	Stomach
COSM4955869	c.694G>A	p.A232T	Substitution - Missense	Liver
COSM1462008	c.2380G>A	p.E794K	Substitution - Missense	Skin
COSM4960835	c.3182G>A	p.G1061E	Substitution - Missense	Liver
COSM3748985	c.1195A>G	p.R399G	Substitution - Missense	Stomach
COSM455833	c.742G>A	p.E248K	Substitution - Missense	Breast
COSM4793720	c.5209C>T	p.P1737S	Substitution - Missense	Liver
COSM3433092	c.3043C>T	p.R1015C	Substitution - Missense	Large_intestine
COSM13367	c.4645C>T	p.H1549Y	Substitution - Missense	Central_nervous_system
COSM3763885	c.1111A>G	p.M371V	Substitution - Missense	Large_intestine
COSM4793720	c.5209C>T	p.P1737S	Substitution - Missense	Liver
COSM5670870	c.4342A>G	p.T1448A	Substitution - Missense	Soft_tissue
COSM487373	c.2104T>A	p.Y702N	Substitution - Missense	Kidney
COSM3906842	c.3170A>G	p.H1057R	Substitution - Missense	Stomach
COSM1267360	c.2743C>A	p.Q915K	Substitution - Missense	Stomach
COSM233539	c.487G>A	p.G163R	Substitution - Missense	Skin
COSM4497679	c.5021C>T	p.S1674F	Substitution - Missense	Skin
COSM4407839	c.3763C>T	p.R1255W	Substitution - Missense	Liver
COSM5998236	c.1526C>T	p.A509V	Substitution - Missense	Prostate
COSM5900171	c.1141T>C	p.F381L	Substitution - Missense	Skin
COSM273326	c.3096T>C	p.P1032P	Substitution - coding silent	Stomach
COSM1267361	c.4835C>A	p.A1612D	Substitution - Missense	Oesophagus
COSM4949758	c.2059C>A	p.P687T	Substitution - Missense	Liver
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Breast
COSM1497077	c.1194T>C	p.S398S	Substitution - coding silent	Kidney
COSM1132511	c.2605G>A	p.A869T	Substitution - Missense	Breast
COSM4565209	c.1859_1860CC>TT	p.P620L	Substitution - Missense	Skin
COSM1108221	c.4208C>T	p.T1403M	Substitution - Missense	Endometrium
COSM3656863	c.1814G>A	p.G605E	Substitution - Missense	Skin
COSM1624904	c.3624T>C	p.A1208A	Substitution - coding silent	Liver
COSM1720632	c.1969C>T	p.P657S	Substitution - Missense	Skin
COSM5593371	c.1603G>A	p.E535K	Substitution - Missense	Skin
COSM1701035	c.1678C>T	p.L560F	Substitution - Missense	Skin
COSM4774449	c.992C>T	p.T331M	Substitution - Missense	Stomach
COSM3656871	c.891G>A	p.V297V	Substitution - coding silent	Skin
COSM3952654	c.2682G>T	p.E894D	Substitution - Missense	Lung
COSM2772188	c.4800G>A	p.K1600K	Substitution - coding silent	Large_intestine
COSM3656840	c.3843G>A	p.L1281L	Substitution - coding silent	Skin
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM277586	c.2534G>A	p.R845Q	Substitution - Missense	Biliary_tract
COSM5890456	c.302G>A	p.R101K	Substitution - Missense	Skin
COSM1108237	c.2377C>T	p.R793W	Substitution - Missense	Endometrium
COSM3848331	c.3565A>T	p.T1189S	Substitution - Missense	Breast
COSM3656857	c.2338G>A	p.D780N	Substitution - Missense	Skin
COSM3906839	c.4631C>A	p.S1544Y	Substitution - Missense	Stomach
COSM267547	c.3693delT	p.F1231fs*20	Deletion - Frameshift	Large_intestine
COSM5817642	c.801A>T	p.P267P	Substitution - coding silent	Liver
COSM3745964	c.5205A>G	p.P1735P	Substitution - coding silent	Liver
COSM5780456	c.741C>T	p.T247T	Substitution - coding silent	Breast
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Large_intestine
COSM5558201	c.184A>T	p.K62*	Substitution - Nonsense	Prostate
COSM2772206	c.4093C>T	p.P1365S	Substitution - Missense	Skin
COSM1737676	c.4526G>A	p.R1509H	Substitution - Missense	Central_nervous_system
COSM1701033	c.3709G>C	p.E1237Q	Substitution - Missense	Skin
COSM3656829	c.5320G>A	p.E1774K	Substitution - Missense	Skin
COSM455831	c.761_762insT	p.P255fs*33	Insertion - Frameshift	Breast
COSM1462000	c.4066C>T	p.R1356C	Substitution - Missense	Skin
COSM5185052	c.3826C>T	p.R1276C	Substitution - Missense	Small_intestine
COSM3779944	c.4627G>C	p.D1543H	Substitution - Missense	Urinary_tract
COSM108018	c.2349C>T	p.I783I	Substitution - coding silent	Skin
COSM4977288	c.5325T>C	p.D1775D	Substitution - coding silent	Oesophagus
COSM5699979	c.2567A>T	p.H856L	Substitution - Missense	Soft_tissue
COSM5907528	c.1573G>A	p.D525N	Substitution - Missense	Skin
COSM3926685	c.1509C>T	p.I503I	Substitution - coding silent	Skin
COSM3656835	c.4428G>A	p.A1476A	Substitution - coding silent	Skin
COSM1108224	c.3755G>A	p.R1252Q	Substitution - Missense	Biliary_tract
COSM5410987	c.303G>A	p.R101R	Substitution - coding silent	Skin
COSM1108237	c.2377C>T	p.R793W	Substitution - Missense	Skin
COSM487368	c.4735C>A	p.H1579N	Substitution - Missense	Kidney
COSM3413592	c.4899T>A	p.L1633L	Substitution - coding silent	Central_nervous_system
COSM3782224	c.3719G>A	p.R1240Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5809483	c.4425T>C	p.S1475S	Substitution - coding silent	Liver
COSM3413593	c.3391A>G	p.K1131E	Substitution - Missense	Stomach
COSM1701032	c.3772G>A	p.E1258K	Substitution - Missense	Skin
COSM21039	c.219G>T	p.L73L	Substitution - coding silent	Skin
COSM2772177	c.5330G>A	p.G1777E	Substitution - Missense	Large_intestine
COSM753649	c.5354C>A	p.P1785H	Substitution - Missense	Lung
COSM4409712	c.1284T>C	p.H428H	Substitution - coding silent	Oesophagus
COSM2772288	c.606C>T	p.F202F	Substitution - coding silent	Skin
COSM5595406	c.2852G>A	p.W951*	Substitution - Nonsense	Skin
COSM3906844	c.2663G>A	p.R888H	Substitution - Missense	Stomach
COSM455832	c.760C>T	p.R254*	Substitution - Nonsense	Skin
COSM487367	c.5467G>T	p.G1823W	Substitution - Missense	Kidney
COSM5009570	c.857G>A	p.R286H	Substitution - Missense	Stomach
COSM5485076	c.1500G>T	p.E500D	Substitution - Missense	Large_intestine
COSM216839	c.1873C>G	p.H625D	Substitution - Missense	Pancreas
COSM608358	c.3239G>A	p.R1080H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5998656	c.1832C>A	p.S611*	Substitution - Nonsense	Prostate
COSM21251	c.5472C>A	p.H1824Q	Substitution - Missense	Lung
COSM5424431	c.4677T>C	p.Y1559Y	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4551505	c.5305G>A	p.G1769R	Substitution - Missense	Skin
COSM251158	c.3782A>T	p.K1261M	Substitution - Missense	Liver
COSM753633	c.2054G>T	p.R685L	Substitution - Missense	Lung
COSM1267357	c.351A>G	p.E117E	Substitution - coding silent	Oesophagus
COSM3375227	c.4123C>T	p.R1375W	Substitution - Missense	Thyroid
COSM3656861	c.1962A>G	p.S654S	Substitution - coding silent	Skin
COSM5808170	c.1223A>T	p.E408V	Substitution - Missense	Liver
COSM1108241	c.2218G>A	p.E740K	Substitution - Missense	Endometrium
COSM1132511	c.2605G>A	p.A869T	Substitution - Missense	Breast
COSM12931	c.2382A>C	p.E794D	Substitution - Missense	Lung
COSM247699	c.4186C>T	p.R1396C	Substitution - Missense	Prostate
COSM455828	c.2495G>A	p.R832H	Substitution - Missense	Breast
COSM4904923	c.2065G>A	p.D689N	Substitution - Missense	Skin
COSM1624905	c.2848C>A	p.P950T	Substitution - Missense	Liver
COSM4538288	c.2529G>A	p.R843R	Substitution - coding silent	Skin
COSM1108247	c.1255G>A	p.E419K	Substitution - Missense	Stomach
COSM5698054	c.3396C>A	p.T1132T	Substitution - coding silent	Soft_tissue
COSM277586	c.2534G>A	p.R845Q	Substitution - Missense	Large_intestine
COSM1240362	c.2524C>T	p.R842W	Substitution - Missense	Oesophagus
COSM5467676	c.3249G>T	p.E1083D	Substitution - Missense	Large_intestine
COSM1228428	c.2038G>T	p.E680*	Substitution - Nonsense	Large_intestine
COSM5359494	c.2494C>T	p.R832C	Substitution - Missense	Large_intestine
COSM753636	c.3403C>G	p.Q1135E	Substitution - Missense	Cervix
COSM1737774	c.4183C>T	p.R1395*	Substitution - Nonsense	Central_nervous_system
COSM20659	c.2553delA	p.A852fs*14	Deletion - Frameshift	Large_intestine
COSM12932	c.2250G>T	p.L750F	Substitution - Missense	Lung
COSM3848335	c.2028A>G	p.S676S	Substitution - coding silent	Breast
COSM5410986	c.933G>A	p.W311*	Substitution - Nonsense	Skin
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM3395782	c.4963C>G	p.P1655A	Substitution - Missense	Pancreas
COSM1108222	c.4190G>A	p.R1397H	Substitution - Missense	Endometrium
COSM1108234	c.2778C>A	p.S926S	Substitution - coding silent	Endometrium
COSM1108252	c.445G>T	p.D149Y	Substitution - Missense	Endometrium
COSM21039	c.219G>T	p.L73L	Substitution - coding silent	Skin
COSM5695839	c.1531C>T	p.P511S	Substitution - Missense	Soft_tissue
COSM3779946	c.1320C>G	p.I440M	Substitution - Missense	Urinary_tract
COSM5571297	c.1048G>A	p.V350M	Substitution - Missense	Prostate
COSM1108219	c.4305C>A	p.D1435E	Substitution - Missense	Endometrium
COSM1581802	c.5057A>G	p.D1686G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4731988	c.1525G>A	p.A509T	Substitution - Missense	Large_intestine
COSM323725	c.5314G>A	p.D1772N	Substitution - Missense	Lung
COSM4797226	c.3447G>A	p.R1149R	Substitution - coding silent	Liver
COSM5676643	c.3445C>T	p.R1149W	Substitution - Missense	Soft_tissue
COSM5040587	c.4238A>T	p.N1413I	Substitution - Missense	Liver
COSM265920	c.2842G>A	p.A948T	Substitution - Missense	Large_intestine
COSM273327	c.1907G>A	p.R636H	Substitution - Missense	Endometrium
COSM6013462	c.5474G>A	p.G1825E	Substitution - Missense	Skin
COSM487371	c.3731G>A	p.R1244Q	Substitution - Missense	Kidney
COSM226648	c.2662C>T	p.R888C	Substitution - Missense	Skin
COSM5926700	c.5161G>A	p.E1721K	Substitution - Missense	Skin
COSM4752320	c.2672C>T	p.T891M	Substitution - Missense	Stomach
COSM753647	c.4867A>G	p.I1623V	Substitution - Missense	Lung
COSM753636	c.3403C>G	p.Q1135E	Substitution - Missense	Lung
COSM3848332	c.3533C>T	p.S1178F	Substitution - Missense	Breast
COSM4935602	c.5089A>G	p.T1697A	Substitution - Missense	Liver
COSM455830	c.1660C>G	p.L554V	Substitution - Missense	Breast
COSM307572	c.1765G>A	p.D589N	Substitution - Missense	Skin
COSM5966022	c.643C>G	p.Q215E	Substitution - Missense	Breast
COSM4839009	c.4907A>G	p.D1636G	Substitution - Missense	Cervix
COSM3413593	c.3391A>G	p.K1131E	Substitution - Missense	Central_nervous_system
COSM4731983	c.3757C>G	p.L1253V	Substitution - Missense	Large_intestine
COSM364122	c.3962A>T	p.E1321V	Substitution - Missense	Lung
COSM4495329	c.4515C>A	p.D1505E	Substitution - Missense	Skin
COSM5998236	c.1526C>T	p.A509V	Substitution - Missense	Prostate
COSM1665792	c.5002_5003delAT	p.M1668fs*2	Deletion - Frameshift	Kidney
COSM5410983	c.3359G>A	p.G1120E	Substitution - Missense	Skin
COSM370296	c.262_263GG>TC	p.G88>?	Complex	Lung
COSM213006	c.5070G>T	p.L1690F	Substitution - Missense	Breast
COSM3926683	c.3627C>T	p.V1209V	Substitution - coding silent	Skin
COSM5948687	c.5132T>A	p.L1711Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5586739	c.1590G>A	p.L530L	Substitution - coding silent	Skin
COSM1462014	c.1616C>T	p.A539V	Substitution - Missense	Large_intestine
COSM1554706	c.189G>A	p.K63K	Substitution - coding silent	Large_intestine
COSM487371	c.3731G>A	p.R1244Q	Substitution - Missense	Pancreas
COSM3952655	c.2467C>A	p.R823R	Substitution - coding silent	Lung
COSM5668628	c.4411A>T	p.I1471F	Substitution - Missense	Soft_tissue
COSM3656855	c.2436G>A	p.G812G	Substitution - coding silent	Skin
COSM1108255	c.98G>A	p.G33D	Substitution - Missense	Endometrium
COSM2772191	c.4772T>C	p.V1591A	Substitution - Missense	Stomach
COSM4007131	c.1647G>C	p.K549N	Substitution - Missense	Urinary_tract
COSM4138926	c.2835A>T	p.E945D	Substitution - Missense	Kidney
COSM753637	c.3433C>T	p.R1145W	Substitution - Missense	Large_intestine
COSM753645	c.4564G>T	p.D1522Y	Substitution - Missense	Lung
COSM3952656	c.2001G>T	p.K667N	Substitution - Missense	Lung
COSM4435973	c.4601T>C	p.V1534A	Substitution - Missense	Large_intestine
COSM108566	c.1765G>T	p.D589Y	Substitution - Missense	Skin
COSM3656854	c.2591G>T	p.R864M	Substitution - Missense	Skin
COSM1462005	c.2784delT	p.F928fs*13	Deletion - Frameshift	Large_intestine
COSM1462026	c.113C>T	p.A38V	Substitution - Missense	Large_intestine
COSM3656853	c.2628G>A	p.M876I	Substitution - Missense	Skin
COSM1108224	c.3755G>A	p.R1252Q	Substitution - Missense	Central_nervous_system
COSM4609453	c.5362G>T	p.A1788S	Substitution - Missense	Adrenal_gland
COSM3926682	c.3635C>T	p.A1212V	Substitution - Missense	Skin
COSM455834	c.692T>C	p.L231S	Substitution - Missense	Breast
COSM753631	c.1937C>A	p.A646E	Substitution - Missense	Lung
COSM1108221	c.4208C>T	p.T1403M	Substitution - Missense	Liver
COSM1581803	c.4765G>A	p.D1589N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656843	c.3598C>T	p.R1200C	Substitution - Missense	Skin
COSM3656837	c.4218C>T	p.S1406S	Substitution - coding silent	Skin
COSM1108209	c.5230C>A	p.L1744I	Substitution - Missense	Endometrium
COSM3413596	c.1673G>T	p.R558L	Substitution - Missense	Central_nervous_system
COSM4968391	c.3922C>A	p.P1308T	Substitution - Missense	Adrenal_gland
COSM164777	c.3754C>T	p.R1252W	Substitution - Missense	Central_nervous_system
COSM5046338	c.1995_1996insA	p.A666fs*38	Insertion - Frameshift	Oesophagus
COSM12932	c.2250G>T	p.L750F	Substitution - Missense	Lung
COSM487367	c.5467G>T	p.G1823W	Substitution - Missense	Lung
COSM4588769	c.3367A>G	p.I1123V	Substitution - Missense	Bone
COSM88014	c.390G>T	p.L130F	Substitution - Missense	Central_nervous_system
COSM5902934	c.5221G>A	p.D1741N	Substitution - Missense	Skin
COSM1462011	c.1994_1995insA	p.A666fs*38	Insertion - Frameshift	Large_intestine
COSM5582707	c.3218C>T	p.S1073F	Substitution - Missense	Skin
COSM1569293	c.2617C>T	p.R873C	Substitution - Missense	Liver
COSM3848330	c.3643C>T	p.R1215C	Substitution - Missense	Large_intestine
COSM1624905	c.2848C>A	p.P950T	Substitution - Missense	Liver
COSM5817133	c.3547T>C	p.C1183R	Substitution - Missense	Liver
COSM1462025	c.126C>T	p.F42F	Substitution - coding silent	Large_intestine
COSM5893414	c.158G>A	p.G53E	Substitution - Missense	Skin
COSM13368	c.2625G>A	p.G875G	Substitution - coding silent	Skin
COSM273327	c.1907G>A	p.R636H	Substitution - Missense	Large_intestine
COSM3848336	c.1996G>A	p.A666T	Substitution - Missense	Breast
COSM3906833	c.5241A>T	p.E1747D	Substitution - Missense	Stomach
COSM4955869	c.694G>A	p.A232T	Substitution - Missense	Liver
COSM110612	c.689C>T	p.P230L	Substitution - Missense	Skin
COSM2772277	c.1167G>A	p.K389K	Substitution - coding silent	Large_intestine
COSM753650	c.5356T>A	p.F1786I	Substitution - Missense	Lung
COSM216839	c.1873C>G	p.H625D	Substitution - Missense	Pancreas
COSM5033442	c.1995G>A	p.K665K	Substitution - coding silent	Oesophagus
COSM403876	c.3113A>C	p.K1038T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656831	c.5195C>T	p.P1732L	Substitution - Missense	Skin
COSM167572	c.3572G>A	p.R1191Q	Substitution - Missense	Skin
COSM3656849	c.2942G>A	p.G981E	Substitution - Missense	Skin
COSM1624906	c.773T>C	p.V258A	Substitution - Missense	Liver
COSM393853	c.5195C>A	p.P1732H	Substitution - Missense	Lung
COSM4898524	c.3026G>A	p.G1009E	Substitution - Missense	Skin
COSM5919759	c.2260C>T	p.H754Y	Substitution - Missense	Skin
COSM5551116	c.972T>C	p.C324C	Substitution - coding silent	Prostate
COSM355325	c.4751G>T	p.R1584L	Substitution - Missense	Lung
COSM273326	c.3096T>C	p.P1032P	Substitution - coding silent	Large_intestine
COSM5932503	c.1003C>T	p.P335S	Substitution - Missense	Skin
COSM1489932	c.4086C>G	p.L1362L	Substitution - coding silent	Breast
COSM20436	c.1994delA	p.K665fs*4	Deletion - Frameshift	Large_intestine
COSM3395785	c.156G>A	p.E52E	Substitution - coding silent	Pancreas
COSM1331580	c.1435G>A	p.D479N	Substitution - Missense	Ovary
COSM3782224	c.3719G>A	p.R1240Q	Substitution - Missense	Pancreas
COSM4731985	c.2247delC	p.L750fs*33	Deletion - Frameshift	Large_intestine
COSM2772251	c.2437C>T	p.P813S	Substitution - Missense	Skin
COSM5721303	c.3585G>C	p.G1195G	Substitution - coding silent	Skin
COSM4568703	c.1280T>G	p.L427R	Substitution - Missense	Skin
COSM21039	c.219G>T	p.L73L	Substitution - coding silent	Skin
COSM3656878	c.561C>T	p.P187P	Substitution - coding silent	Skin
COSM5487298	c.5407G>A	p.G1803S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3656866	c.1331G>A	p.G444E	Substitution - Missense	Skin
COSM4638647	c.2538G>T	p.M846I	Substitution - Missense	Large_intestine
COSM108018	c.2349C>T	p.I783I	Substitution - coding silent	Liver
COSM3784228	c.3481G>A	p.G1161R	Substitution - Missense	Prostate
COSM1108251	c.585G>A	p.L195L	Substitution - coding silent	Endometrium
COSM1267362	c.4360C>T	p.R1454C	Substitution - Missense	Stomach
COSM1462008	c.2380G>A	p.E794K	Substitution - Missense	Skin
COSM3906840	c.3868G>A	p.G1290R	Substitution - Missense	Stomach
COSM5809483	c.4425T>C	p.S1475S	Substitution - coding silent	Liver
COSM3926685	c.1509C>T	p.I503I	Substitution - coding silent	Skin

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
27571988	Mutation	Colorectal Carcinoma; Gastric Carcinoma	In the present study, we found TAF1 frameshift mutations (3.8% of CRC with MSI-H) and TAF1L frameshift mutations (2.9% of GC and 3.8% of CRC with MSI-H).
24007313	Mutation	Oral Cavity Squamous Cell Carcinoma	We further identified 515 significantly mutated genes (SMGs) and 156 tumor-specific disruptive genes (TDGs), with six genes in both sets, including ANKRA2, GTF2H5, STOML1, NUP37, PPP1R26, and TAF1L.
24755198	Mutation	Melanoma	Third, we identified 12 significantly mutated genes in pan-negative samples (ALK, STK31, DGKI, RAC1, EPHA4, ADAMTS18, EPHA7, ERBB4, TAF1L, NF1, SYK, and KDR), including five genes (RAC1, ADAMTS18, EPHA7, TAF1L, and NF1) with a recurrent mutation in at least two pan-negative tumor samples.
26873642	Mutation	Malignant Urinary System Neoplasm	Tissue of the case with 11.5 month SD harbored a missense mutation of mTOR (E1813D), the nonsense mutation Q527STOP of TSC1, HER3 and TAF1L missense mutations.

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	0.525	-0.362	-0.722	0.0111	Under
BRCA	Breast invasive carcinoma	112	1100	1.022	0.559	-0.519	6.45e-07	NS
CESC	Cervical and endocervical cancers	3	306	0.048	-0.096	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	0.081	0.918	0.887	3.53e-08	Over
ESCA	Esophageal carcinoma	11	185	0.91	1.038	-0.002	0.995	NS
GBM	Glioblastoma multiforme	5	166	0.333	-0.194	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	1.479	1.32	-0.231	0.258	NS
KIRC	Kidney renal clear cell carcinoma	72	534	0.103	-0.088	-0.27	0.0101	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	-0.009	-0.413	-0.53	0.0183	NS
LAML	Acute Myeloid Leukemia	0	173	NA	1.961	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	0.501	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-1.479	-1.578	-0.373	0.0629	NS
LUAD	Lung adenocarcinoma	59	517	0.466	0.324	-0.063	0.65	NS
LUSC	Lung squamous cell carcinoma	51	501	0.216	0.213	-0.076	0.539	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	-0.078	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-0.053	-0.145	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.376	-0.582	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.508	0.107	-0.521	0.00529	NS
READ	Rectum adenocarcinoma	10	167	0.266	1.147	0.988	0.00524	Over
SARC	Sarcoma	2	263	-0.287	1.399	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	-0.459	0.298	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	0.682	0.829	0.214	0.206	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	0.829	NA	NA	NA
THCA	Thyroid carcinoma	59	509	0.779	0.358	-0.478	0.00217	NS
THYM	Thymoma	2	120	0.164	-1.071	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	0.548	1.019	-0.144	0.637	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	4.2
Autonomic ganglia	CHP212	4.3
Autonomic ganglia	IMR32	4.5
Autonomic ganglia	KELLY	4.1
Autonomic ganglia	KPNRTBM1	4.4
Autonomic ganglia	KPNSI9S	4.2
Autonomic ganglia	KPNYN	4.3
Autonomic ganglia	MHHNB11	4.5
Autonomic ganglia	NB1	4.4
Autonomic ganglia	NH6	4.3
Autonomic ganglia	SHSY5Y	4.4
Autonomic ganglia	SIMA	4.4
Autonomic ganglia	SKNAS	4.8
Autonomic ganglia	SKNBE2	4.3
Autonomic ganglia	SKNDZ	4.4
Autonomic ganglia	SKNFI	5.2
Autonomic ganglia	SKNSH	4.2
Biliary tract	HUCCT1	4.4
Biliary tract	HUH28	4.4
Biliary tract	SNU1079	4
Biliary tract	SNU1196	4.2
Biliary tract	SNU245	4.5
Biliary tract	SNU308	4.3
Biliary tract	SNU478	3.9
Bone	143B	4.1
Bone	A673	4.6
Bone	CADOES1	4.2
Bone	CAL78	4.4
Bone	G292CLONEA141B1	4.2
Bone	HOS	4.2
Bone	HS706T	4.6
Bone	HS737T	4.3
Bone	HS819T	4.3
Bone	HS821T	4.4
Bone	HS822T	4.9
Bone	HS863T	4.4
Bone	HS870T	4.8
Bone	HS888T	4.3
Bone	MG63	4.2
Bone	MHHES1	4.5
Bone	OUMS27	4.1
Bone	RDES	4.3
Bone	SJSA1	4.3
Bone	SKES1	4.7
Bone	SKNMC	4.3
Bone	SW1353	3.9
Bone	T173	4.5
Bone	TC71	4.4
Bone	U2OS	4
Breast	AU565	4.6
Breast	BT20	4.4
Breast	BT474	4.5
Breast	BT483	4.5
Breast	BT549	4.8
Breast	CAL120	4.2
Breast	CAL148	4
Breast	CAL51	4.6
Breast	CAL851	4.1
Breast	CAMA1	4.2
Breast	DU4475	4.1
Breast	EFM192A	4.3
Breast	EFM19	4.4
Breast	EVSAT	4.8
Breast	HCC1143	4.3
Breast	HCC1187	4.3
Breast	HCC1395	4.1
Breast	HCC1419	4.3
Breast	HCC1428	4.6
Breast	HCC1500	4.4
Breast	HCC1569	4.5
Breast	HCC1599	4
Breast	HCC1806	4.3
Breast	HCC1937	4.2
Breast	HCC1954	4.4
Breast	HCC202	4.2
Breast	HCC2157	4.3
Breast	HCC2218	4.7
Breast	HCC38	4.1
Breast	HCC70	4.6
Breast	HDQP1	4.2
Breast	HMC18	5.1
Breast	HS274T	4.2
Breast	HS281T	4.2
Breast	HS343T	4.2
Breast	HS578T	4.3
Breast	HS606T	4.4
Breast	HS739T	4.2
Breast	HS742T	4
Breast	JIMT1	4.2
Breast	KPL1	4.5
Breast	MCF7	4.4
Breast	MDAMB134VI	4.6
Breast	MDAMB157	4
Breast	MDAMB175VII	4.1
Breast	MDAMB231	4.2
Breast	MDAMB361	4.3
Breast	MDAMB415	4.4
Breast	MDAMB436	4.2
Breast	MDAMB453	4.4
Breast	MDAMB468	4.3
Breast	SKBR3	4.3
Breast	T47D	4
Breast	UACC812	4.3
Breast	UACC893	4.3
Breast	YMB1	4.4
Breast	ZR751	4.5
Breast	ZR7530	4.6
Central nervous system	1321N1	4.3
Central nervous system	42MGBA	4.2
Central nervous system	8MGBA	4.4
Central nervous system	A172	4.2
Central nervous system	AM38	4.2
Central nervous system	BECKER	4.3
Central nervous system	CAS1	4.3
Central nervous system	CCFSTTG1	4.2
Central nervous system	D283MED	4.5
Central nervous system	D341MED	4.9
Central nervous system	DAOY	4.6
Central nervous system	DBTRG05MG	4
Central nervous system	DKMG	4.1
Central nervous system	GAMG	4
Central nervous system	GB1	4.8
Central nervous system	GI1	4.4
Central nervous system	GMS10	4.1
Central nervous system	GOS3	4.6
Central nervous system	H4	3.9
Central nervous system	HS683	4.2
Central nervous system	KALS1	4.3
Central nervous system	KG1C	3.9
Central nervous system	KNS42	4.3
Central nervous system	KNS60	4.5
Central nervous system	KNS81	4.4
Central nervous system	KS1	4.1
Central nervous system	LN18	4.3
Central nervous system	LN229	4.2
Central nervous system	M059K	4.7
Central nervous system	MOGGCCM	4.4
Central nervous system	MOGGUVW	4.1
Central nervous system	NMCG1	4.2
Central nervous system	ONS76	4.1
Central nervous system	SF126	4.2
Central nervous system	SF295	4.2
Central nervous system	SNB19	4.3
Central nervous system	SNU1105	4.1
Central nervous system	SNU201	4
Central nervous system	SNU466	4.1
Central nervous system	SNU489	4.3
Central nervous system	SNU626	4.6
Central nervous system	SNU738	4.5
Central nervous system	SW1088	4.4
Central nervous system	SW1783	4.1
Central nervous system	T98G	4.5
Central nervous system	TM31	4.1
Central nervous system	U118MG	4.3
Central nervous system	U138MG	4.2
Central nervous system	U251MG	4.2
Central nervous system	U87MG	4.3
Central nervous system	YH13	4.3
Central nervous system	YKG1	4.2
Endometrium	AN3CA	4.7
Endometrium	COLO684	4.3
Endometrium	EFE184	4.6
Endometrium	EN	4.2
Endometrium	ESS1	4.2
Endometrium	HEC108	4.5
Endometrium	HEC151	4.4
Endometrium	HEC1A	4
Endometrium	HEC1B	4.1
Endometrium	HEC251	4.2
Endometrium	HEC265	4.5
Endometrium	HEC50B	4.4
Endometrium	HEC59	4.4
Endometrium	HEC6	4.3
Endometrium	ISHIKAWAHERAKLIO02ER	4.4
Endometrium	JHUEM1	4.2
Endometrium	JHUEM2	4.6
Endometrium	JHUEM3	4.2
Endometrium	KLE	4
Endometrium	MFE280	4.1
Endometrium	MFE296	4.3
Endometrium	MFE319	5.1
Endometrium	RL952	4.2
Endometrium	SNGM	4.1
Endometrium	SNU1077	4
Endometrium	SNU685	4.5
Endometrium	TEN	4.3
Haematopoietic and lymphoid	697	4.7
Haematopoietic and lymphoid	A3KAW	4.4
Haematopoietic and lymphoid	A4FUK	4.6
Haematopoietic and lymphoid	ALLSIL	4.6
Haematopoietic and lymphoid	AML193	4.4
Haematopoietic and lymphoid	AMO1	4.3
Haematopoietic and lymphoid	BCP1	4.9
Haematopoietic and lymphoid	BDCM	4.5
Haematopoietic and lymphoid	BL41	4.4
Haematopoietic and lymphoid	BL70	4.4
Haematopoietic and lymphoid	BV173	4.6
Haematopoietic and lymphoid	CA46	4.4
Haematopoietic and lymphoid	CI1	4.5
Haematopoietic and lymphoid	CMK115	4.5
Haematopoietic and lymphoid	CMK86	4.5
Haematopoietic and lymphoid	CMK	4.2
Haematopoietic and lymphoid	CMLT1	4.3
Haematopoietic and lymphoid	COLO775	4.6
Haematopoietic and lymphoid	DAUDI	4.2
Haematopoietic and lymphoid	DB	4.5
Haematopoietic and lymphoid	DEL	4.6
Haematopoietic and lymphoid	DND41	4.5
Haematopoietic and lymphoid	DOHH2	4.4
Haematopoietic and lymphoid	EB1	4.4
Haematopoietic and lymphoid	EB2	4.5
Haematopoietic and lymphoid	EHEB	4.3
Haematopoietic and lymphoid	EJM	4.7
Haematopoietic and lymphoid	EM2	4.6
Haematopoietic and lymphoid	EOL1	4.4
Haematopoietic and lymphoid	F36P	4.9
Haematopoietic and lymphoid	GA10	4.3
Haematopoietic and lymphoid	GDM1	4.7
Haematopoietic and lymphoid	GRANTA519	4.3
Haematopoietic and lymphoid	HDLM2	4.4
Haematopoietic and lymphoid	HDMYZ	4.4
Haematopoietic and lymphoid	HEL9217	3.9
Haematopoietic and lymphoid	HEL	4.2
Haematopoietic and lymphoid	HH	4.3
Haematopoietic and lymphoid	HL60	5
Haematopoietic and lymphoid	HPBALL	4.1
Haematopoietic and lymphoid	HS604T	4.3
Haematopoietic and lymphoid	HS611T	4.6
Haematopoietic and lymphoid	HS616T	4.2
Haematopoietic and lymphoid	HS751T	4.2
Haematopoietic and lymphoid	HT	4.6
Haematopoietic and lymphoid	HTK	4.7
Haematopoietic and lymphoid	HUNS1	4.6
Haematopoietic and lymphoid	HUT102	4.3
Haematopoietic and lymphoid	HUT78	4
Haematopoietic and lymphoid	JEKO1	4.5
Haematopoietic and lymphoid	JK1	4.6
Haematopoietic and lymphoid	JM1	4.6
Haematopoietic and lymphoid	JURKAT	4.6
Haematopoietic and lymphoid	JURLMK1	4.3
Haematopoietic and lymphoid	JVM2	4.6
Haematopoietic and lymphoid	JVM3	4.5
Haematopoietic and lymphoid	K562	4.7
Haematopoietic and lymphoid	KARPAS299	4.3
Haematopoietic and lymphoid	KARPAS422	4.6
Haematopoietic and lymphoid	KARPAS620	5
Haematopoietic and lymphoid	KASUMI1	4.3
Haematopoietic and lymphoid	KASUMI2	4.3
Haematopoietic and lymphoid	KASUMI6	4.3
Haematopoietic and lymphoid	KCL22	4.3
Haematopoietic and lymphoid	KE37	4.4
Haematopoietic and lymphoid	KE97	4.6
Haematopoietic and lymphoid	KG1	4.2
Haematopoietic and lymphoid	KHM1B	4.5
Haematopoietic and lymphoid	KIJK	4.6
Haematopoietic and lymphoid	KMH2	5.1
Haematopoietic and lymphoid	KMM1	4.2
Haematopoietic and lymphoid	KMS11	4.5
Haematopoietic and lymphoid	KMS12BM	4.4
Haematopoietic and lymphoid	KMS18	4.2
Haematopoietic and lymphoid	KMS20	4.2
Haematopoietic and lymphoid	KMS21BM	4.8
Haematopoietic and lymphoid	KMS26	4.5
Haematopoietic and lymphoid	KMS27	4.5
Haematopoietic and lymphoid	KMS28BM	4.2
Haematopoietic and lymphoid	KMS34	4.5
Haematopoietic and lymphoid	KO52	4.6
Haematopoietic and lymphoid	KOPN8	4.4
Haematopoietic and lymphoid	KU812	4.8
Haematopoietic and lymphoid	KYO1	4.6
Haematopoietic and lymphoid	L1236	4.3
Haematopoietic and lymphoid	L363	4.9
Haematopoietic and lymphoid	L428	4.5
Haematopoietic and lymphoid	L540	4.4
Haematopoietic and lymphoid	LAMA84	4.3
Haematopoietic and lymphoid	LOUCY	4.7
Haematopoietic and lymphoid	LP1	4.6
Haematopoietic and lymphoid	M07E	4.5
Haematopoietic and lymphoid	MC116	4.6
Haematopoietic and lymphoid	ME1	4.6
Haematopoietic and lymphoid	MEC1	4.5
Haematopoietic and lymphoid	MEC2	4.5
Haematopoietic and lymphoid	MEG01	4.2
Haematopoietic and lymphoid	MHHCALL2	4.7
Haematopoietic and lymphoid	MHHCALL3	4.5
Haematopoietic and lymphoid	MHHCALL4	4.5
Haematopoietic and lymphoid	MINO	4.3
Haematopoietic and lymphoid	MJ	4.7
Haematopoietic and lymphoid	MM1S	4.3
Haematopoietic and lymphoid	MOLM13	4.6
Haematopoietic and lymphoid	MOLM16	4.5
Haematopoietic and lymphoid	MOLM6	4.1
Haematopoietic and lymphoid	MOLP2	4.4
Haematopoietic and lymphoid	MOLP8	4.5
Haematopoietic and lymphoid	MOLT13	4.1
Haematopoietic and lymphoid	MOLT16	4.8
Haematopoietic and lymphoid	MOLT4	4.3
Haematopoietic and lymphoid	MONOMAC1	4.9
Haematopoietic and lymphoid	MONOMAC6	4.5
Haematopoietic and lymphoid	MOTN1	4.6
Haematopoietic and lymphoid	MUTZ5	4.3
Haematopoietic and lymphoid	MV411	4.8
Haematopoietic and lymphoid	NALM19	4.3
Haematopoietic and lymphoid	NALM1	4.6
Haematopoietic and lymphoid	NALM6	4.7
Haematopoietic and lymphoid	NAMALWA	4.9
Haematopoietic and lymphoid	NB4	4.6
Haematopoietic and lymphoid	NCIH929	4.5
Haematopoietic and lymphoid	NCO2	4.9
Haematopoietic and lymphoid	NOMO1	4.4
Haematopoietic and lymphoid	NUDHL1	4.3
Haematopoietic and lymphoid	NUDUL1	4.8
Haematopoietic and lymphoid	OCIAML2	4.4
Haematopoietic and lymphoid	OCIAML3	4.3
Haematopoietic and lymphoid	OCIAML5	4.3
Haematopoietic and lymphoid	OCILY10	4.9
Haematopoietic and lymphoid	OCILY19	4.4
Haematopoietic and lymphoid	OCILY3	5.5
Haematopoietic and lymphoid	OCIM1	4.7
Haematopoietic and lymphoid	OPM2	4.9
Haematopoietic and lymphoid	P12ICHIKAWA	4.6
Haematopoietic and lymphoid	P31FUJ	4.4
Haematopoietic and lymphoid	P3HR1	4.7
Haematopoietic and lymphoid	PCM6	4.5
Haematopoietic and lymphoid	PEER	4.5
Haematopoietic and lymphoid	PF382	4.5
Haematopoietic and lymphoid	PFEIFFER	4.5
Haematopoietic and lymphoid	PL21	4.6
Haematopoietic and lymphoid	RAJI	4.5
Haematopoietic and lymphoid	RCHACV	4.2
Haematopoietic and lymphoid	REC1	4.8
Haematopoietic and lymphoid	REH	4.6
Haematopoietic and lymphoid	RI1	4.4
Haematopoietic and lymphoid	RL	4.4
Haematopoietic and lymphoid	RPMI8226	4.4
Haematopoietic and lymphoid	RPMI8402	4.8
Haematopoietic and lymphoid	RS411	4.5
Haematopoietic and lymphoid	SEM	4.5
Haematopoietic and lymphoid	SET2	4.4
Haematopoietic and lymphoid	SIGM5	5.1
Haematopoietic and lymphoid	SKM1	4.3
Haematopoietic and lymphoid	SKMM2	4.3
Haematopoietic and lymphoid	SR786	4.4
Haematopoietic and lymphoid	ST486	5.1
Haematopoietic and lymphoid	SUDHL10	4.3
Haematopoietic and lymphoid	SUDHL1	4.5
Haematopoietic and lymphoid	SUDHL4	4.3
Haematopoietic and lymphoid	SUDHL5	4.8
Haematopoietic and lymphoid	SUDHL6	5.1
Haematopoietic and lymphoid	SUDHL8	4.5
Haematopoietic and lymphoid	SUPB15	4.2
Haematopoietic and lymphoid	SUPHD1	4.1
Haematopoietic and lymphoid	SUPM2	4.6
Haematopoietic and lymphoid	SUPT11	4.3
Haematopoietic and lymphoid	SUPT1	4.7
Haematopoietic and lymphoid	TALL1	4.5
Haematopoietic and lymphoid	TF1	4.3
Haematopoietic and lymphoid	THP1	4.3
Haematopoietic and lymphoid	TO175T	4.6
Haematopoietic and lymphoid	TOLEDO	4.5
Haematopoietic and lymphoid	U266B1	4.4
Haematopoietic and lymphoid	U937	4.6
Haematopoietic and lymphoid	UT7	4.6
Haematopoietic and lymphoid	WSUDLCL2	4.4
Kidney	769P	4
Kidney	786O	4.4
Kidney	A498	4.5
Kidney	A704	4.6
Kidney	ACHN	4.4
Kidney	BFTC909	4.9
Kidney	CAKI1	4.4
Kidney	CAKI2	4.1
Kidney	CAL54	4
Kidney	KMRC1	4.4
Kidney	KMRC20	4.5
Kidney	KMRC2	4.9
Kidney	KMRC3	4.5
Kidney	OSRC2	4.2
Kidney	RCC10RGB	4.4
Kidney	SNU1272	4.2
Kidney	SNU349	4.5
Kidney	TUHR10TKB	4.5
Kidney	TUHR14TKB	3.9
Kidney	TUHR4TKB	4.1
Kidney	VMRCRCW	4.4
Kidney	VMRCRCZ	4.3
Large intestine	C2BBE1	4.5
Large intestine	CCK81	4.4
Large intestine	CL11	4.3
Large intestine	CL14	4.1
Large intestine	CL34	4.6
Large intestine	CL40	4.2
Large intestine	COLO205	4.4
Large intestine	COLO320	4.5
Large intestine	COLO678	4.7
Large intestine	CW2	3.9
Large intestine	DLD1	4.1
Large intestine	GP2D	4.2
Large intestine	HCC56	4.4
Large intestine	HCT116	4.3
Large intestine	HCT15	4.3
Large intestine	HS675T	4.3
Large intestine	HS698T	4.2
Large intestine	HT115	4.2
Large intestine	HT29	4.1
Large intestine	HT55	4.5
Large intestine	KM12	5
Large intestine	LOVO	4.2
Large intestine	LS1034	4.6
Large intestine	LS123	4.4
Large intestine	LS180	4.6
Large intestine	LS411N	4.2
Large intestine	LS513	4.4
Large intestine	MDST8	4
Large intestine	NCIH508	4.4
Large intestine	NCIH716	4
Large intestine	NCIH747	4.1
Large intestine	OUMS23	4.1
Large intestine	RCM1	4.5
Large intestine	RKO	4.7
Large intestine	SKCO1	4.3
Large intestine	SNU1040	4
Large intestine	SNU1197	4.3
Large intestine	SNU175	4.1
Large intestine	SNU283	4.8
Large intestine	SNU407	4.3
Large intestine	SNU503	4.1
Large intestine	SNU61	4.4
Large intestine	SNU81	4.7
Large intestine	SNUC1	4.3
Large intestine	SNUC2A	4
Large intestine	SNUC4	4.1
Large intestine	SNUC5	4.1
Large intestine	SW1116	3.9
Large intestine	SW1417	4.3
Large intestine	SW1463	4.3
Large intestine	SW403	4.6
Large intestine	SW480	4.2
Large intestine	SW48	4.6
Large intestine	SW620	4.4
Large intestine	SW837	4.7
Large intestine	SW948	4
Large intestine	T84	4.7
Liver	ALEXANDERCELLS	4.3
Liver	C3A	4.3
Liver	HEP3B217	4.2
Liver	HEPG2	4.2
Liver	HLE	4.3
Liver	HLF	4.4
Liver	HUH1	4.2
Liver	HUH6	4.2
Liver	HUH7	4
Liver	JHH1	4.5
Liver	JHH2	4.4
Liver	JHH4	5
Liver	JHH5	4.1
Liver	JHH6	4.3
Liver	JHH7	4.9
Liver	LI7	4.1
Liver	PLCPRF5	4.3
Liver	SKHEP1	4.1
Liver	SNU182	4.3
Liver	SNU387	4.5
Liver	SNU398	4.3
Liver	SNU423	4.6
Liver	SNU449	4.7
Liver	SNU475	4.5
Liver	SNU761	3.9
Liver	SNU878	4.7
Liver	SNU886	4.6
Lung	A549	4.4
Lung	ABC1	4.2
Lung	BEN	4.4
Lung	CAL12T	4.6
Lung	CALU1	4.6
Lung	CALU3	4.6
Lung	CALU6	4
Lung	CHAGOK1	4.2
Lung	COLO668	4.4
Lung	COLO699	4.1
Lung	CORL105	4.5
Lung	CORL23	4.1
Lung	CORL24	4.4
Lung	CORL279	4.5
Lung	CORL311	4.4
Lung	CORL47	4.4
Lung	CORL51	4.3
Lung	CORL88	4.3
Lung	CORL95	4.3
Lung	CPCN	4.3
Lung	DMS114	4.4
Lung	DMS153	4.7
Lung	DMS273	4.8
Lung	DMS454	4.1
Lung	DMS53	4.4
Lung	DMS79	4.6
Lung	DV90	4.1
Lung	EBC1	4.5
Lung	EPLC272H	4.6
Lung	HARA	4.3
Lung	HCC1171	3.8
Lung	HCC1195	4.5
Lung	HCC15	4.8
Lung	HCC2279	4.3
Lung	HCC2935	4.4
Lung	HCC33	4.2
Lung	HCC366	4.2
Lung	HCC4006	4.3
Lung	HCC44	4
Lung	HCC78	4.2
Lung	HCC827	4.4
Lung	HCC95	4.4
Lung	HLC1	4.3
Lung	HLFA	4.4
Lung	HS229T	4.6
Lung	HS618T	4.4
Lung	IALM	4.6
Lung	KNS62	4.4
Lung	LC1F	4.2
Lung	LC1SQSF	4.5
Lung	LCLC103H	4.5
Lung	LCLC97TM1	4.4
Lung	LK2	4
Lung	LOUNH91	4.5
Lung	LU65	4.9
Lung	LU99	4.4
Lung	LUDLU1	4.5
Lung	LXF289	4.3
Lung	MORCPR	4.5
Lung	NCIH1048	4.2
Lung	NCIH1092	4.4
Lung	NCIH1105	4.6
Lung	NCIH1155	4.4
Lung	NCIH1184	4.5
Lung	NCIH1299	5.2
Lung	NCIH1339	4.4
Lung	NCIH1341	4.4
Lung	NCIH1355	4
Lung	NCIH1373	4.8
Lung	NCIH1385	4.2
Lung	NCIH1395	4.3
Lung	NCIH1435	4.4
Lung	NCIH1436	4.1
Lung	NCIH1437	4.5
Lung	NCIH146	4.5
Lung	NCIH1563	4.8
Lung	NCIH1568	4.2
Lung	NCIH1573	4.3
Lung	NCIH1581	4.3
Lung	NCIH1618	4.6
Lung	NCIH1623	4.2
Lung	NCIH1648	4.5
Lung	NCIH1650	4.4
Lung	NCIH1651	4.2
Lung	NCIH1666	4.2
Lung	NCIH1693	4
Lung	NCIH1694	4.4
Lung	NCIH1703	4.5
Lung	NCIH1734	4.3
Lung	NCIH1755	4.2
Lung	NCIH1781	4.1
Lung	NCIH1792	4
Lung	NCIH1793	4.3
Lung	NCIH1836	4.3
Lung	NCIH1838	4.7
Lung	NCIH1869	4.2
Lung	NCIH1876	4.4
Lung	NCIH1915	4.2
Lung	NCIH1930	4.5
Lung	NCIH1944	4.4
Lung	NCIH1963	4.6
Lung	NCIH196	4.3
Lung	NCIH1975	4.3
Lung	NCIH2009	4.3
Lung	NCIH2023	4.4
Lung	NCIH2029	4.5
Lung	NCIH2030	4.1
Lung	NCIH2066	4.4
Lung	NCIH2081	4.8
Lung	NCIH2085	4.2
Lung	NCIH2087	4.1
Lung	NCIH209	4.2
Lung	NCIH2106	4.4
Lung	NCIH2110	4.1
Lung	NCIH211	4.7
Lung	NCIH2122	4.1
Lung	NCIH2126	4.2
Lung	NCIH2141	4.2
Lung	NCIH2170	4.5
Lung	NCIH2171	4.2
Lung	NCIH2172	4.6
Lung	NCIH2196	4.3
Lung	NCIH2227	4.2
Lung	NCIH2228	4.2
Lung	NCIH226	4.5
Lung	NCIH2286	4.4
Lung	NCIH2291	4
Lung	NCIH2342	3.9
Lung	NCIH2347	4.4
Lung	NCIH23	4.3
Lung	NCIH2405	4.7
Lung	NCIH2444	4.6
Lung	NCIH292	4.3
Lung	NCIH322	5.1
Lung	NCIH3255	4.2
Lung	NCIH358	4.5
Lung	NCIH441	4.4
Lung	NCIH446	4.6
Lung	NCIH460	4.5
Lung	NCIH510	4.4
Lung	NCIH520	4.5
Lung	NCIH522	4
Lung	NCIH524	4.2
Lung	NCIH526	4.5
Lung	NCIH596	4.1
Lung	NCIH647	4.6
Lung	NCIH650	4.6
Lung	NCIH661	4.4
Lung	NCIH69	4.4
Lung	NCIH727	4.1
Lung	NCIH810	4.5
Lung	NCIH82	4.3
Lung	NCIH838	4.1
Lung	NCIH841	4.9
Lung	NCIH854	4.2
Lung	NCIH889	4.2
Lung	PC14	4.3
Lung	RERFLCAD1	4.2
Lung	RERFLCAD2	4.7
Lung	RERFLCAI	4.2
Lung	RERFLCKJ	4.9
Lung	RERFLCMS	4.2
Lung	RERFLCSQ1	4
Lung	SBC5	4.3
Lung	SCLC21H	4.5
Lung	SHP77	4.6
Lung	SKLU1	4.2
Lung	SKMES1	3.9
Lung	SQ1	4.2
Lung	SW1271	4
Lung	SW1573	4.3
Lung	SW900	4.4
Lung	VMRCLCD	4.4
Lung	VMRCLCP	4.3
Oesophagus	COLO680N	4.1
Oesophagus	ECGI10	4.1
Oesophagus	KYSE140	4.4
Oesophagus	KYSE150	4.6
Oesophagus	KYSE180	4.7
Oesophagus	KYSE270	4.2
Oesophagus	KYSE30	4.4
Oesophagus	KYSE410	4.6
Oesophagus	KYSE450	4.2
Oesophagus	KYSE510	4.8
Oesophagus	KYSE520	4.3
Oesophagus	KYSE70	4.3
Oesophagus	OE19	4.5
Oesophagus	OE33	4.8
Oesophagus	TE10	4.1
Oesophagus	TE11	4.4
Oesophagus	TE14	4.1
Oesophagus	TE15	4.1
Oesophagus	TE1	4.2
Oesophagus	TE4	4
Oesophagus	TE5	4.3
Oesophagus	TE6	4.2
Oesophagus	TE8	4.3
Oesophagus	TE9	4.5
Oesophagus	TT	4.4
Ovary	59M	4.2
Ovary	A2780	4.5
Ovary	CAOV3	4.2
Ovary	CAOV4	4.3
Ovary	COLO704	4.3
Ovary	COV318	4.4
Ovary	COV362	4.2
Ovary	COV434	4.4
Ovary	COV504	4.3
Ovary	COV644	4.4
Ovary	EFO21	4.4
Ovary	EFO27	4
Ovary	ES2	4.5
Ovary	FUOV1	4.3
Ovary	HEYA8	4.4
Ovary	HS571T	4.1
Ovary	IGROV1	4.4
Ovary	JHOC5	4
Ovary	JHOM1	4.1
Ovary	JHOM2B	4.1
Ovary	JHOS2	4.2
Ovary	JHOS4	4.2
Ovary	KURAMOCHI	4.4
Ovary	MCAS	3.9
Ovary	NIHOVCAR3	4.4
Ovary	OAW28	4.1
Ovary	OAW42	4.2
Ovary	OC314	4.1
Ovary	OC316	4.2
Ovary	ONCODG1	4.1
Ovary	OV56	4.4
Ovary	OV7	4.1
Ovary	OV90	4.3
Ovary	OVCAR4	4.3
Ovary	OVCAR8	4.4
Ovary	OVISE	4.3
Ovary	OVK18	3.9
Ovary	OVKATE	4.5
Ovary	OVMANA	4.4
Ovary	OVSAHO	4.4
Ovary	OVTOKO	4.5
Ovary	RMGI	4.7
Ovary	RMUGS	4.4
Ovary	SKOV3	4.2
Ovary	SNU119	4.1
Ovary	SNU840	4.4
Ovary	SNU8	4
Ovary	TOV112D	4.8
Ovary	TOV21G	4
Ovary	TYKNU	4.6
Pancreas	ASPC1	4.1
Pancreas	BXPC3	4.6
Pancreas	CAPAN1	4.4
Pancreas	CAPAN2	4.5
Pancreas	CFPAC1	4.7
Pancreas	DANG	4.2
Pancreas	HPAC	4.5
Pancreas	HPAFII	4.6
Pancreas	HS766T	4
Pancreas	HUPT3	4.2
Pancreas	HUPT4	4.5
Pancreas	KCIMOH1	4.3
Pancreas	KLM1	4.7
Pancreas	KP2	4.2
Pancreas	KP3	4.1
Pancreas	KP4	4.2
Pancreas	L33	4.2
Pancreas	MIAPACA2	5
Pancreas	PANC0203	4.3
Pancreas	PANC0213	4.2
Pancreas	PANC0327	4.6
Pancreas	PANC0403	4.6
Pancreas	PANC0504	4
Pancreas	PANC0813	4.4
Pancreas	PANC1005	4.5
Pancreas	PANC1	5
Pancreas	PATU8902	4.1
Pancreas	PATU8988S	4.2
Pancreas	PATU8988T	4.5
Pancreas	PK1	4.2
Pancreas	PK45H	4.2
Pancreas	PK59	4.6
Pancreas	PL45	3.9
Pancreas	PSN1	5
Pancreas	QGP1	4.4
Pancreas	SNU213	4.2
Pancreas	SNU324	4.1
Pancreas	SNU410	4.2
Pancreas	SU8686	4
Pancreas	SUIT2	4.3
Pancreas	SW1990	4.1
Pancreas	T3M4	4.5
Pancreas	TCCPAN2	4.6
Pancreas	YAPC	4.1
Pleura	ACCMESO1	4.1
Pleura	DM3	4.2
Pleura	ISTMES1	4.1
Pleura	ISTMES2	4
Pleura	JL1	4.3
Pleura	MPP89	4.6
Pleura	MSTO211H	4.6
Pleura	NCIH2052	4.2
Pleura	NCIH2452	4.2
Pleura	NCIH28	4.4
Prostate	22RV1	4.3
Prostate	DU145	4
Prostate	LNCAPCLONEFGC	4.2
Prostate	MDAPCA2B	4.3
Prostate	NCIH660	4.4
Prostate	PC3	4.5
Prostate	VCAP	4.2
Salivary gland	A253	4.2
Salivary gland	YD15	4.5
Skin	A101D	4
Skin	A2058	4.7
Skin	A375	4
Skin	C32	4.2
Skin	CHL1	4.1
Skin	CJM	4.4
Skin	COLO679	4.4
Skin	COLO741	4.2
Skin	COLO783	4.1
Skin	COLO792	4.4
Skin	COLO800	3.9
Skin	COLO818	4.5
Skin	COLO829	4.4
Skin	COLO849	4.2
Skin	G361	4.3
Skin	GRM	4.5
Skin	HMCB	4.3
Skin	HS294T	4.4
Skin	HS600T	4
Skin	HS688AT	4.3
Skin	HS695T	4
Skin	HS839T	4.8
Skin	HS852T	4.4
Skin	HS895T	4.4
Skin	HS934T	4.3
Skin	HS936T	5.3
Skin	HS939T	4.3
Skin	HS940T	4
Skin	HS944T	4
Skin	HT144	4.1
Skin	IGR1	4.1
Skin	IGR37	4.3
Skin	IGR39	4.2
Skin	IPC298	4
Skin	K029AX	3.9
Skin	LOXIMVI	4.4
Skin	MALME3M	4.2
Skin	MDAMB435S	4.6
Skin	MELHO	4.8
Skin	MELJUSO	4.3
Skin	MEWO	4.9
Skin	RPMI7951	4.6
Skin	RVH421	4
Skin	SH4	4.3
Skin	SKMEL1	3.8
Skin	SKMEL24	4.1
Skin	SKMEL28	4.2
Skin	SKMEL2	4.3
Skin	SKMEL30	4.3
Skin	SKMEL31	4.7
Skin	SKMEL3	4.1
Skin	SKMEL5	4.5
Skin	UACC257	4.5
Skin	UACC62	4.1
Skin	WM115	4.1
Skin	WM1799	4.5
Skin	WM2664	4.3
Skin	WM793	4.3
Skin	WM88	4.6
Skin	WM983B	4.6
Small intestine	HUTU80	4.3
Soft tissue	A204	4.3
Soft tissue	G401	4.5
Soft tissue	G402	4.8
Soft tissue	GCT	4.4
Soft tissue	HS729	4.7
Soft tissue	HT1080	4.2
Soft tissue	KYM1	4.5
Soft tissue	MESSA	4.7
Soft tissue	RD	4.1
Soft tissue	RH30	4.9
Soft tissue	RH41	4.3
Soft tissue	RKN	4.1
Soft tissue	S117	4.7
Soft tissue	SJRH30	4.4
Soft tissue	SKLMS1	4.3
Soft tissue	SKUT1	4.4
Soft tissue	TE125T	4.1
Soft tissue	TE159T	4
Soft tissue	TE441T	4.5
Soft tissue	TE617T	4.5
Stomach	2313287	4.5
Stomach	AGS	4.2
Stomach	AZ521	4.6
Stomach	ECC10	4.2
Stomach	ECC12	4.1
Stomach	FU97	4.4
Stomach	GCIY	4
Stomach	GSS	4.3
Stomach	GSU	4.1
Stomach	HGC27	4.4
Stomach	HS746T	4.5
Stomach	HUG1N	4.1
Stomach	IM95	4.7
Stomach	KATOIII	4.3
Stomach	KE39	4.5
Stomach	LMSU	4.1
Stomach	MKN1	4.2
Stomach	MKN45	4.6
Stomach	MKN74	4
Stomach	MKN7	4.2
Stomach	NCCSTCK140	4.2
Stomach	NCIN87	4.3
Stomach	NUGC2	4.2
Stomach	NUGC3	4.3
Stomach	NUGC4	4.6
Stomach	OCUM1	4.4
Stomach	RERFGC1B	3.9
Stomach	SH10TC	4.7
Stomach	SNU16	4.3
Stomach	SNU1	4.5
Stomach	SNU216	4
Stomach	SNU520	4.1
Stomach	SNU5	4.6
Stomach	SNU601	4.6
Stomach	SNU620	4.4
Stomach	SNU668	5.1
Stomach	SNU719	4.9
Stomach	TGBC11TKB	4.4
Thyroid	8305C	4.4
Thyroid	8505C	4.4
Thyroid	BCPAP	4.7
Thyroid	BHT101	4.7
Thyroid	CAL62	4.5
Thyroid	CGTHW1	4.4
Thyroid	FTC133	4.4
Thyroid	FTC238	4.2
Thyroid	ML1	4.2
Thyroid	SW579	4.3
Thyroid	TT2609C02	4.3
Thyroid	TT	4
Upper aerodigestive tract	BHY	4.2
Upper aerodigestive tract	BICR16	4.2
Upper aerodigestive tract	BICR18	4.1
Upper aerodigestive tract	BICR22	4.5
Upper aerodigestive tract	BICR31	4.3
Upper aerodigestive tract	BICR56	4.3
Upper aerodigestive tract	BICR6	4.4
Upper aerodigestive tract	CAL27	4.3
Upper aerodigestive tract	CAL33	4.5
Upper aerodigestive tract	DETROIT562	3.7
Upper aerodigestive tract	FADU	4.5
Upper aerodigestive tract	HS840T	4.2
Upper aerodigestive tract	HSC2	4.5
Upper aerodigestive tract	HSC3	4.2
Upper aerodigestive tract	HSC4	4.1
Upper aerodigestive tract	PECAPJ15	4.3
Upper aerodigestive tract	PECAPJ34CLONEC12	4.3
Upper aerodigestive tract	PECAPJ41CLONED2	4.5
Upper aerodigestive tract	PECAPJ49	4.3
Upper aerodigestive tract	SCC15	4.2
Upper aerodigestive tract	SCC25	4.2
Upper aerodigestive tract	SCC4	4.3
Upper aerodigestive tract	SCC9	4.2
Upper aerodigestive tract	SNU1076	4.4
Upper aerodigestive tract	SNU1214	4
Upper aerodigestive tract	SNU46	4.4
Upper aerodigestive tract	SNU899	4.1
Upper aerodigestive tract	YD10B	4.4
Upper aerodigestive tract	YD38	4.3
Upper aerodigestive tract	YD8	4.1
Urinary tract	5637	4.1
Urinary tract	639V	5
Urinary tract	647V	4.3
Urinary tract	BC3C	4.5
Urinary tract	BFTC905	4.5
Urinary tract	CAL29	4.3
Urinary tract	HS172T	4
Urinary tract	HT1197	4.2
Urinary tract	HT1376	4.1
Urinary tract	J82	4
Urinary tract	JMSU1	4
Urinary tract	KMBC2	4
Urinary tract	KU1919	4.5
Urinary tract	RT11284	4.2
Urinary tract	RT112	4.7
Urinary tract	RT4	4.1
Urinary tract	SCABER	4.3
Urinary tract	SW1710	4.2
Urinary tract	SW780	4.2
Urinary tract	T24	4.5
Urinary tract	TCCSUP	4.7
Urinary tract	UMUC1	4.6
Urinary tract	UMUC3	4.3
Urinary tract	VMCUB1	4.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0
Adrenal gland	0
Appendix	0
Bone marrow	0
Breast	0
Cerebral cortex	0
Cervix, uterine	0
Colon	0
Duodenum	0
Endometrium	0
Epididymis	0
Esophagus	0
Fallopian tube	0
Gallbladder	0
Heart muscle	0
Kidney	0
Liver	0
Lung	0
Lymph node	0
Ovary	0
Pancreas	0
Parathyroid gland	0
Placenta	0
Prostate	0
Rectum	0
Salivary gland	0
Seminal vesicle	0
Skeletal muscle	0
Skin	0
Small intestine	0
Smooth muscle	0
Spleen	0
Stomach	0
Testis	3
Thyroid gland	0
Tonsil	0
Urinary bladder	0

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	-0.104	0.0369	42.6	38.6	18.8	Loss
BRCA	Breast invasive carcinoma	1075	-0.041	0.178	28.1	56.8	15.1	Neutral
CESC	Cervical and endocervical cancers	292	0.03	0.611	19.2	64.7	16.1	Neutral
COAD	Colon adenocarcinoma	449	-0.001	0.986	12.2	70.4	17.4	Neutral
ESCA	Esophageal carcinoma	183	-0.016	0.831	50.3	30.6	19.1	Loss
GBM	Glioblastoma multiforme	147	0.068	0.412	38.8	47.6	13.6	Loss
HNSC	Head and Neck squamous cell carcinoma	514	-0.083	0.0608	35.6	41.2	23.2	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.045	0.298	28.2	69.3	2.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.123	0.0373	11.1	87.8	1	Neutral
LAML	Acute Myeloid Leukemia	166	-0.048	0.541	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	-0.052	0.237	20.7	77	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.075	0.153	28.8	64.6	6.6	Neutral
LUAD	Lung adenocarcinoma	512	0.022	0.624	44.5	41.4	14.1	Loss
LUSC	Lung squamous cell carcinoma	498	0.031	0.496	54.4	21.5	24.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.012	0.84	38.7	37.3	24	Loss
PAAD	Pancreatic adenocarcinoma	177	0.067	0.374	33.3	57.6	9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.038	0.63	6.2	90.7	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.017	0.709	5.1	87.4	7.5	Neutral
READ	Rectum adenocarcinoma	164	0.025	0.752	13.4	59.1	27.4	Neutral
SARC	Sarcoma	255	0.013	0.832	31.4	47.1	21.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	-0.094	0.0707	62.4	30.2	7.4	Loss
STAD	Stomach adenocarcinoma	413	0.143	0.00354	30	52.1	17.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	-0.02	0.805	38.7	48.7	12.7	Loss
THCA	Thyroid carcinoma	497	0.096	0.0325	3.6	95.6	0.8	Neutral
THYM	Thymoma	119	-0.099	0.286	3.4	88.2	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.1	0.0209	14.2	78.6	7.3	Neutral

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	0.029	0.546	17	408	-0.18	5.48e-18	NS/NA
BRCA	Breast invasive carcinoma	0.033	0.325	83	785	-0.145	1.7e-69	NS/NA
CESC	Cervical and endocervical cancers	-0.125	0.028	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.069	0.221	19	297	-0.011	0.00144	NS/NA
ESCA	Esophageal carcinoma	-0.074	0.302	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.23	0.0657	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	0.063	0.144	20	522	-0.059	6.81e-13	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.015	0.788	24	319	-0.026	3.41e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.055	0.34	23	275	0.032	0.214	NS/NA
LAML	Acute Myeloid Leukemia	0.073	0.346	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.059	0.177	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.011	0.821	41	373	-0.338	3.1e-45	Decreased
LUAD	Lung adenocarcinoma	0.114	0.0125	21	456	-0.003	0.000687	NS/NA
LUSC	Lung squamous cell carcinoma	0.015	0.775	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.267	0.493	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.034	0.645	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.037	0.614	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	0.051	0.237	35	498	-0.163	2.73e-14	NS/NA
READ	Rectum adenocarcinoma	-0.127	0.204	2	99	NA	NA	NS/NA
SARC	Sarcoma	0.147	0.0168	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.091	0.0479	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.047	0.369	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.304	0.00012	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	0.012	0.777	50	509	0.019	0.812	NS/NA
THYM	Thymoma	0.024	0.791	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.062	0.183	34	431	-0.044	1.17e-17	NS/NA

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.939	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000114	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0671	NS	22810696
GBM	Glioblastoma multiforme	157	0.255	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00106	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0127	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.0629	NS	26824661
LUAD	Lung adenocarcinoma	230	0.0172	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.102	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0317	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0011	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0962	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.159	NS	26091043
STAD	Stomach adenocarcinoma	277	0.375	NS	25079317
THCA	Thyroid carcinoma	391	0.195	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.591	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.064	0.779	NS
BRCA	Breast invasive carcinoma	1079	1.766	0.013	Shorter
CESC	Cervical and endocervical cancers	291	1.463	0.305	NS
COAD	Colon adenocarcinoma	439	1.455	0.199	NS
ESCA	Esophageal carcinoma	184	1.03	0.925	NS
GBM	Glioblastoma multiforme	158	0.752	0.251	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.81	0.288	NS
KIRC	Kidney renal clear cell carcinoma	531	0.43	0.000374	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.685	0.235	NS
LAML	Acute Myeloid Leukemia	149	0.738	0.311	NS
LGG	Brain Lower Grade Glioma	511	1.077	0.778	NS
LIHC	Liver hepatocellular carcinoma	365	0.842	0.494	NS
LUAD	Lung adenocarcinoma	502	0.829	0.364	NS
LUSC	Lung squamous cell carcinoma	494	0.888	0.533	NS
OV	Ovarian serous cystadenocarcinoma	303	1.817	0.00501	Shorter
PAAD	Pancreatic adenocarcinoma	177	1.365	0.27	NS
PCPG	Pheochromocytoma and Paraganglioma	179	611228936.056	0.152	NS
PRAD	Prostate adenocarcinoma	497	1.716	0.604	NS
READ	Rectum adenocarcinoma	159	0.95	0.907	NS
SARC	Sarcoma	259	1.295	0.379	NS
SKCM	Skin Cutaneous Melanoma	459	0.913	0.65	NS
STAD	Stomach adenocarcinoma	388	0.814	0.335	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.317	NS
THCA	Thyroid carcinoma	500	1.399	0.712	NS
THYM	Thymoma	119	1.029	0.981	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.925	0.785	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.041	0.412	NS
BRCA	Breast invasive carcinoma	1071	-0.018	0.555	NS
CESC	Cervical and endocervical cancers	167	-0.033	0.676	NS
COAD	Colon adenocarcinoma	445	-0.001	0.983	NS
ESCA	Esophageal carcinoma	162	0.049	0.534	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.031	0.511	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.132	0.00236	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.031	0.621	NS
LIHC	Liver hepatocellular carcinoma	347	0.074	0.171	NS
LUAD	Lung adenocarcinoma	507	0.025	0.581	NS
LUSC	Lung squamous cell carcinoma	497	0.027	0.547	NS
OV	Ovarian serous cystadenocarcinoma	302	0.061	0.289	NS
PAAD	Pancreatic adenocarcinoma	176	0.03	0.697	NS
READ	Rectum adenocarcinoma	156	-0.111	0.169	NS
SKCM	Skin Cutaneous Melanoma	410	0.01	0.843	NS
STAD	Stomach adenocarcinoma	392	0.045	0.377	NS
TGCT	Testicular Germ Cell Tumors	81	-0.123	0.275	NS
THCA	Thyroid carcinoma	499	-0.038	0.396	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.068	0.131	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.083	0.172	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.061	0.176	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.126	0.00376	Lower
LGG	Brain Lower Grade Glioma	514	0.053	0.232	NS
LIHC	Liver hepatocellular carcinoma	366	-0.04	0.45	NS
OV	Ovarian serous cystadenocarcinoma	296	0.046	0.426	NS
PAAD	Pancreatic adenocarcinoma	176	0.022	0.773	NS
STAD	Stomach adenocarcinoma	406	-0.006	0.905	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.128	0.00298	Lower

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TAF1L.

Summary
Symbol	TAF1L
Name	TATA-box binding protein associated factor 1 like
Aliases	TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ......
Location	9p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for TAF1L.

> Interactions from Text Mining [ TOP ]
There is no record for TAF1L.