CR2Cancer

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF08513 LisH
PF00400 WD domain

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	15601853

> Gene Ontology [ TOP ]
Biological Process	GO:0002021 response to dietary excess GO:0006140 regulation of nucleotide metabolic process GO:0006476 protein deacetylation GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009187 cyclic nucleotide metabolic process GO:0009991 response to extracellular stimulus GO:0010498 proteasomal protein catabolic process GO:0016042 lipid catabolic process GO:0016055 Wnt signaling pathway GO:0016570 histone modification GO:0016575 histone deacetylation GO:0019216 regulation of lipid metabolic process GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030814 regulation of cAMP metabolic process GO:0031667 response to nutrient levels GO:0035264 multicellular organism growth GO:0035601 protein deacylation GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045444 fat cell differentiation GO:0046058 cAMP metabolic process GO:0046486 glycerolipid metabolic process GO:0050872 white fat cell differentiation GO:0060070 canonical Wnt signaling pathway GO:0060612 adipose tissue development GO:0060613 fat pad development GO:0061448 connective tissue development GO:0090207 regulation of triglyceride metabolic process GO:0098732 macromolecule deacylation GO:0198738 cell-cell signaling by wnt GO:1900542 regulation of purine nucleotide metabolic process
Molecular Function	GO:0003714 transcription corepressor activity GO:0008013 beta-catenin binding GO:0042393 histone binding GO:0047485 protein N-terminus binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0005819 spindle GO:0005874 microtubule GO:0005876 spindle microtubule GO:0017053 transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04310 Wnt signaling pathway
Reactome	R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-1368082: RORA activates gene expression R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04310 Wnt signaling pathway

Reactome

R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-1368108: BMAL1
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-1368082: RORA activates gene expression
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5655980	c.571T>C	p.S191P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1420705	c.728G>T	p.G243V	Substitution - Missense	Large_intestine
COSM4804467	c.1105G>T	p.D369Y	Substitution - Missense	Liver
COSM4979992	c.718C>G	p.L240V	Substitution - Missense	Oesophagus
COSM5045035	c.974G>A	p.C325Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5949456	c.800G>T	p.G267V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM445989	c.204+1G>C	p.?	Unknown	Breast
COSM4952082	c.142G>T	p.A48S	Substitution - Missense	Liver
COSM4440696	c.1256C>T	p.S419F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1420706	c.377delA	p.N126fs*16	Deletion - Frameshift	Pancreas
COSM4763652	c.1122G>T	p.K374N	Substitution - Missense	Stomach
COSM4440695	c.1261G>C	p.D421H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1235256	c.614delG	p.G205fs*5	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4732473	c.140C>A	p.A47D	Substitution - Missense	Large_intestine
COSM1316247	c.1457T>G	p.I486R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708588	c.869C>G	p.T290R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440712	c.230C>T	p.P77L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708598	c.688_690delTCT	p.S230delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM729837	c.222T>C	p.D74D	Substitution - coding silent	Lung
COSM4002522	c.766+5A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4440707	c.596G>A	p.S199N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5575016	c.569A>T	p.D190V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708597	c.740G>A	p.G247E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708570	c.1339A>C	p.S447R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM479736	c.680A>G	p.D227G	Substitution - Missense	Kidney
COSM5514507	c.807A>G	p.I269M	Substitution - Missense	Biliary_tract
COSM1041413	c.1046C>T	p.T349M	Substitution - Missense	Endometrium
COSM1193309	c.868A>G	p.T290A	Substitution - Missense	Lung
COSM345462	c.161A>T	p.Q54L	Substitution - Missense	Lung
COSM4944038	c.1058A>G	p.N353S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041417	c.646C>A	p.R216R	Substitution - coding silent	Endometrium
COSM3205548	c.127C>T	p.L43F	Substitution - Missense	Large_intestine
COSM445988	c.419_420insCA	p.A142fs*1	Insertion - Frameshift	Breast
COSM5791077	c.428-1G>C	p.?	Unknown	Breast
COSM5986221	c.1373C>T	p.A458V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM251160	c.832G>A	p.G278R	Substitution - Missense	Liver
COSM1041411	c.1460T>C	p.F487S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5000343	c.1508C>T	p.S503L	Substitution - Missense	Pancreas
COSM1720649	c.1250G>A	p.S417N	Substitution - Missense	Skin
COSM303843	c.381_382insA	p.E128fs*17	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM445984	c.959_961delACA	p.N320delN	Deletion - In frame	Breast
COSM445986	c.423_424insTA	p.A142fs*1	Insertion - Frameshift	Breast
COSM5679708	c.547C>A	p.L183I	Substitution - Missense	Soft_tissue
COSM277619	c.846A>G	p.L282L	Substitution - coding silent	Large_intestine
COSM4944039	c.47_47delT	p.L16fs*15	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4908452	c.108G>C	p.Q36H	Substitution - Missense	Kidney
COSM3205520	c.1473G>C	p.W491C	Substitution - Missense	Large_intestine
COSM4440711	c.35_38delTATA	p.Y13fs*17	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5888782	c.1382C>T	p.S461F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5459682	c.973T>G	p.C325G	Substitution - Missense	Large_intestine
COSM5708596	c.793C>G	p.H265D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708589	c.866C>T	p.T289I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708593	c.809T>G	p.F270C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708591	c.845T>C	p.L282P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708600	c.502C>G	p.H168D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5713420	c.978_982delTACAG	p.S326fs*8	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5623375	c.418_419insT	p.T140fs*5	Insertion - Frameshift	Oesophagus
COSM4440706	c.637C>A	p.H213N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708575	c.1122+1delG	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5948825	c.1126T>G	p.W376G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708584	c.931G>C	p.A311P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708585	c.920A>G	p.H307R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM359865	c.463G>C	p.V155L	Substitution - Missense	Lung
COSM5708599	c.570C>G	p.D190E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708596	c.793C>G	p.H265D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708588	c.869C>G	p.T290R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708610	c.21G>T	p.E7D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708574	c.1183T>G	p.Y395D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM445987	c.422_423delTA	p.I141fs*3	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5759433	c.125C>T	p.A42V	Substitution - Missense	Bone
COSM5708605	c.421delA	p.I141fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4770139	c.909G>T	p.Q303H	Substitution - Missense	Biliary_tract
COSM1420706	c.377delA	p.N126fs*16	Deletion - Frameshift	Large_intestine
COSM5768289	c.557C>T	p.S186L	Substitution - Missense	Breast
COSM4961926	c.331G>T	p.A111S	Substitution - Missense	Pancreas
COSM1420704	c.1108G>A	p.D370N	Substitution - Missense	Large_intestine
COSM5708581	c.974G>T	p.C325F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440713	c.229C>A	p.P77T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3992874	c.662A>G	p.D221G	Substitution - Missense	Kidney
COSM1235152	c.739G>A	p.G247R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM129624	c.977G>A	p.S326N	Substitution - Missense	Upper_aerodigestive_tract
COSM5708592	c.811G>C	p.A271P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4584120	c.342C>T	p.A114A	Substitution - coding silent	Bone
COSM4149674	c.1071G>T	p.W357C	Substitution - Missense	Ovary
COSM1041419	c.497G>A	p.R166Q	Substitution - Missense	Endometrium
COSM5822845	c.991A>T	p.I331F	Substitution - Missense	Liver
COSM72926	c.281C>G	p.T94R	Substitution - Missense	Ovary
COSM1041418	c.500G>A	p.G167D	Substitution - Missense	Endometrium
COSM4828532	c.1097C>T	p.S366F	Substitution - Missense	Cervix
COSM6006312	c.1092_1093insT	p.A365fs*5	Insertion - Frameshift	Small_intestine
COSM303843	c.381_382insA	p.E128fs*17	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM729838	c.258C>T	p.A86A	Substitution - coding silent	Lung
COSM445986	c.423_424insTA	p.A142fs*1	Insertion - Frameshift	Breast
COSM1228658	c.1339A>G	p.S447G	Substitution - Missense	Large_intestine
COSM4440697	c.1255T>A	p.S419T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5348033	c.1275delG	p.R425fs*5	Deletion - Frameshift	Liver
COSM5708574	c.1183T>G	p.Y395D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3205548	c.127C>T	p.L43F	Substitution - Missense	Large_intestine
COSM1228657	c.1051G>T	p.E351*	Substitution - Nonsense	Large_intestine
COSM3205530	c.1169A>G	p.H390R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708585	c.920A>G	p.H307R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440697	c.1255T>A	p.S419T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708608	c.205-2A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM366449	c.168T>A	p.G56G	Substitution - coding silent	Lung
COSM4440710	c.70T>C	p.S24P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5766440	c.144A>T	p.A48A	Substitution - coding silent	Large_intestine
COSM4766133	c.686C>G	p.T229R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708582	c.971C>T	p.S324F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708590	c.847A>C	p.S283R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5799797	c.1140A>G	p.Q380Q	Substitution - coding silent	Breast
COSM5708610	c.21G>T	p.E7D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM445990	c.106C>T	p.Q36*	Substitution - Nonsense	Breast
COSM1720649	c.1250G>A	p.S417N	Substitution - Missense	Skin
COSM4976469	c.694G>C	p.D232H	Substitution - Missense	Oesophagus
COSM208335	c.1177G>T	p.E393*	Substitution - Nonsense	Endometrium
COSM1041416	c.646C>T	p.R216*	Substitution - Nonsense	Endometrium
COSM303883	c.226C>T	p.R76*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM303811	c.862_864+4delAAGGTAA	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5708595	c.798A>T	p.K266N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708598	c.688_690delTCT	p.S230delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM399941	c.1019G>T	p.R340I	Substitution - Missense	Lung
COSM1632993	c.251_252insC	p.D85fs*6	Insertion - Frameshift	Liver
COSM1041410	c.1462G>A	p.E488K	Substitution - Missense	Breast
COSM5883782	c.268G>T	p.D90Y	Substitution - Missense	Breast
COSM3205534	c.971_973delCTT	p.S324delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM5986599	c.258_259insGCTACCCT	p.V87fs*4	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5708594	c.799G>T	p.G267C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4840356	c.1409A>C	p.N470T	Substitution - Missense	Cervix
COSM5708579	c.1048-2A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5708586	c.920A>C	p.H307P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708592	c.811G>C	p.A271P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM445987	c.422_423delTA	p.I141fs*3	Deletion - Frameshift	Breast
COSM1420702	c.1539G>A	p.R513R	Substitution - coding silent	Large_intestine
COSM4437339	c.520A>G	p.I174V	Substitution - Missense	Oesophagus
COSM5708609	c.119A>G	p.N40S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041411	c.1460T>C	p.F487S	Substitution - Missense	Endometrium
COSM5986598	c.418_419insTA	p.T140fs*3	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1041423	c.257C>A	p.A86D	Substitution - Missense	Endometrium
COSM1041412	c.1047G>A	p.T349T	Substitution - coding silent	Endometrium
COSM1041413	c.1046C>T	p.T349M	Substitution - Missense	Salivary_gland
COSM4440696	c.1256C>T	p.S419F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5421649	c.560+1delG	p.?	Unknown	Prostate
COSM4440703	c.1376G>A	p.S459N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM445985	c.854G>T	p.G285V	Substitution - Missense	Breast
COSM729839	c.974G>C	p.C325S	Substitution - Missense	Lung
COSM1420706	c.377delA	p.N126fs*16	Deletion - Frameshift	Large_intestine
COSM1632994	c.227G>C	p.R76P	Substitution - Missense	Liver
COSM3205534	c.971_973delCTT	p.S324delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1041421	c.467A>G	p.E156G	Substitution - Missense	Endometrium
COSM3702365	c.1128G>T	p.W376C	Substitution - Missense	Liver
COSM4953511	c.595A>G	p.S199G	Substitution - Missense	Liver
COSM5654710	c.586T>C	p.W196R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1420703	c.1183T>C	p.Y395H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440704	c.1336T>G	p.Y446D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM208338	c.883G>A	p.A295T	Substitution - Missense	Large_intestine
COSM4440705	c.1274G>T	p.R425M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5650935	c.926-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1186457	c.337G>T	p.A113S	Substitution - Missense	Lung
COSM4440695	c.1261G>C	p.D421H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM419703	c.1127G>T	p.W376L	Substitution - Missense	Urinary_tract
COSM285606	c.511G>A	p.E171K	Substitution - Missense	Large_intestine
COSM4939743	c.1072G>T	p.D358Y	Substitution - Missense	Oesophagus
COSM1041409	c.1510G>T	p.D504Y	Substitution - Missense	Endometrium
COSM5708580	c.1043A>G	p.H348R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3205524	c.1340G>A	p.S447N	Substitution - Missense	Large_intestine
COSM4440698	c.1335G>T	p.V445V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5708602	c.427+1G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4440709	c.148A>T	p.I50F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4848659	c.649G>C	p.E217Q	Substitution - Missense	Cervix
COSM5708583	c.965T>G	p.F322C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041412	c.1047G>A	p.T349T	Substitution - coding silent	Stomach
COSM4763652	c.1122G>T	p.K374N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3767306	c.764A>G	p.D255G	Substitution - Missense	Liver
COSM3205529	c.1184A>G	p.Y395C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1228659	c.1003A>C	p.K335Q	Substitution - Missense	Large_intestine
COSM4115390	c.345A>C	p.A115A	Substitution - coding silent	Stomach
COSM5708585	c.920A>G	p.H307R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM129625	c.691C>G	p.L231V	Substitution - Missense	Upper_aerodigestive_tract
COSM1327711	c.606_624del19	p.T203fs*1	Deletion - Frameshift	Ovary
COSM3664613	c.100A>G	p.I34V	Substitution - Missense	Breast
COSM4149673	c.1345G>C	p.A449P	Substitution - Missense	Ovary
COSM5708588	c.869C>G	p.T290R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4510536	c.840C>T	p.F280F	Substitution - coding silent	Skin
COSM277620	c.683T>C	p.V228A	Substitution - Missense	Large_intestine
COSM5708578	c.1059T>A	p.N353K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4839161	c.905A>C	p.Q302P	Substitution - Missense	Cervix
COSM445982	c.1489A>T	p.K497*	Substitution - Nonsense	Breast
COSM1041410	c.1462G>A	p.E488K	Substitution - Missense	Endometrium
COSM4440708	c.458G>A	p.G153E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3205524	c.1340G>A	p.S447N	Substitution - Missense	Skin
COSM3205534	c.971_973delCTT	p.S324delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM303824	c.632_633ins14	p.R212fs*25	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5708606	c.409G>T	p.G137*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3915401	c.301G>A	p.D101N	Substitution - Missense	Skin
COSM1617221	c.585A>G	p.I195M	Substitution - Missense	Liver
COSM3915400	c.528C>T	p.A176A	Substitution - coding silent	Skin
COSM1041419	c.497G>A	p.R166Q	Substitution - Missense	Biliary_tract
COSM5708587	c.919C>T	p.H307Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5736832	c.526G>A	p.A176T	Substitution - Missense	Small_intestine
COSM5986222	c.968C>A	p.A323D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM6011296	c.141T>G	p.A47A	Substitution - coding silent	Skin
COSM5045122	c.1337A>G	p.Y446C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1736495	c.200A>G	p.N67S	Substitution - Missense	Central_nervous_system
COSM5708584	c.931G>C	p.A311P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041414	c.1015G>T	p.D339Y	Substitution - Missense	Endometrium
COSM4115388	c.1007T>C	p.L336S	Substitution - Missense	Stomach
COSM729838	c.258C>T	p.A86A	Substitution - coding silent	Breast
COSM5708603	c.424_425insTA	p.A142fs*8	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5708590	c.847A>C	p.S283R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041424	c.174G>T	p.Q58H	Substitution - Missense	Endometrium
COSM4657764	c.1089C>G	p.L363L	Substitution - coding silent	Parathyroid
COSM1130292	c.1048-1G>C	p.?	Unknown	Prostate
COSM4584119	c.1424C>T	p.A475V	Substitution - Missense	Bone
COSM1420707	c.337G>A	p.A113T	Substitution - Missense	Large_intestine
COSM1420706	c.377delA	p.N126fs*16	Deletion - Frameshift	Large_intestine
COSM5708584	c.931G>C	p.A311P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708603	c.424_425insTA	p.A142fs*8	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5708576	c.1106A>G	p.D369G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3205550	c.9A>G	p.I3M	Substitution - Missense	Large_intestine
COSM3719752	c.628G>A	p.V210I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4606933	c.785T>C	p.L262S	Substitution - Missense	Adrenal_gland
COSM4949463	c.1109_1121del13	p.D370fs*5	Deletion - Frameshift	Liver
COSM4456116	c.1257_1258CT>TC	p.F420L	Substitution - Missense	Skin
COSM445987	c.422_423delTA	p.I141fs*3	Deletion - Frameshift	Breast
COSM5708584	c.931G>C	p.A311P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1632994	c.227G>C	p.R76P	Substitution - Missense	Liver
COSM5708568	c.1388A>T	p.D463V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708596	c.793C>G	p.H265D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1235257	c.562T>A	p.S188T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440696	c.1256C>T	p.S419F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM479737	c.531G>T	p.W177C	Substitution - Missense	Kidney
COSM4443459	c.202G>A	p.E68K	Substitution - Missense	Large_intestine
COSM1041420	c.496C>T	p.R166W	Substitution - Missense	Endometrium
COSM251160	c.832G>A	p.G278R	Substitution - Missense	Liver
COSM4513019	c.923C>T	p.S308L	Substitution - Missense	Skin
COSM4953511	c.595A>G	p.S199G	Substitution - Missense	Liver
COSM5414958	c.563C>T	p.S188F	Substitution - Missense	Endometrium
COSM4440699	c.?	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5708604	c.419_423delCTATA	p.T140fs*3	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5708603	c.424_425insTA	p.A142fs*8	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5888782	c.1382C>T	p.S461F	Substitution - Missense	Skin
COSM5986697	c.980_994del15	p.T327_H332>N	Complex - deletion inframe	Haematopoietic_and_lymphoid_tissue
COSM1617221	c.585A>G	p.I195M	Substitution - Missense	Liver
COSM4949463	c.1109_1121del13	p.D370fs*5	Deletion - Frameshift	Liver
COSM445983	c.1145A>G	p.N382S	Substitution - Missense	Breast
COSM208335	c.1177G>T	p.E393*	Substitution - Nonsense	Large_intestine
COSM3205534	c.971_973delCTT	p.S324delS	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM5708569	c.1388A>C	p.D463A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708581	c.974G>T	p.C325F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5509348	c.477T>C	p.P159P	Substitution - coding silent	Biliary_tract
COSM5708578	c.1059T>A	p.N353K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1228656	c.1186A>G	p.T396A	Substitution - Missense	Large_intestine
COSM3846780	c.3G>C	p.M1I	Substitution - Missense	Breast
COSM1177037	c.1387G>A	p.D463N	Substitution - Missense	Endometrium
COSM4610436	c.920A>T	p.H307L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041425	c.113A>G	p.N38S	Substitution - Missense	Endometrium
COSM4939743	c.1072G>T	p.D358Y	Substitution - Missense	Liver
COSM1308833	c.1087C>G	p.L363V	Substitution - Missense	Urinary_tract
COSM5418028	c.702+8T>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM445987	c.422_423delTA	p.I141fs*3	Deletion - Frameshift	Prostate
COSM241852	c.234_235delAG	p.E79fs*11	Deletion - Frameshift	Prostate
COSM1420703	c.1183T>C	p.Y395H	Substitution - Missense	Large_intestine
COSM4437840	c.232delA	p.I78fs*1	Deletion - Frameshift	Oesophagus
COSM4952082	c.142G>T	p.A48S	Substitution - Missense	Liver
COSM1041415	c.763G>T	p.D255Y	Substitution - Missense	Endometrium
COSM5708573	c.1251T>A	p.S417R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708571	c.1259T>G	p.F420C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4828532	c.1097C>T	p.S366F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708607	c.313C>T	p.Q105*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5045073	c.1267A>C	p.T423P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4440696	c.1256C>T	p.S419F	Substitution - Missense	Skin
COSM5708588	c.869C>G	p.T290R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM729840	c.1531G>C	p.D511H	Substitution - Missense	Lung
COSM5708584	c.931G>C	p.A311P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1041422	c.283A>C	p.R95R	Substitution - coding silent	Endometrium
COSM4115389	c.504T>C	p.H168H	Substitution - coding silent	Stomach
COSM5045035	c.974G>A	p.C325Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4005299	c.134C>T	p.P45L	Substitution - Missense	Urinary_tract
COSM3664613	c.100A>G	p.I34V	Substitution - Missense	Breast
COSM4804467	c.1105G>T	p.D369Y	Substitution - Missense	Liver
COSM5708572	c.1255T>C	p.S419P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708577	c.1105G>C	p.D369H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5708601	c.502C>A	p.H168N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
26899600	Mutation	Breast Carcinoma	For breast cancer, we identified a significant MEGS consisting of TP53 and four infrequently mutated genes (ARID1A, AKT1, MED23, and TBL1XR1), providing support for their role as cancer drivers.
26111727	Mutation	Lymphoma	The results showed that 68 out of 71 PCNSLs had mutations in the NF-κB gene network, most commonly affecting CD79B (83%), MYD88 (76%), TBL1XR1 (23%), PRDM1 (20%) and CREBBP1 (20%).
24970810	Mutation	Lymphoma	Focused resequencing in the larger cohort revealed high mutation rates for genes already described as mutated in PCNSL such as MYD88 (38%), CD79B (30%), PIM1 (22%) and TBL1XR1 (19%) and for genes not previously reported to be involved in PCNSL tumorigenesis such as ETV6 (16%), IRF4 (14%), IRF2BP2 (11%) and EBF1 (11%).
22837180	Mutation	Lymphoma	Sequencing of matched tumor and blood DNA samples identified novel somatic mutations in MYD88 and TBL1XR1 in 38% and 14% of the cases, respectively.
22496164	mutation	Lymphoma	Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases.

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9BZK7	102	K	N6-acetyllysine	-	No	None detected
Q9BZK7	119	S	Phosphoserine	-	Yes	p.S119N (cancer: HNSC)

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.754	7.285	0.571	0.000321	NS
BRCA	Breast invasive carcinoma	112	1100	7.189	7.57	0.416	5.31e-12	NS
CESC	Cervical and endocervical cancers	3	306	6.647	7.511	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.989	7.114	0.088	0.364	NS
ESCA	Esophageal carcinoma	11	185	7.023	7.889	0.938	3.98e-05	Over
GBM	Glioblastoma multiforme	5	166	7.12	6.705	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.586	7.253	0.763	1.51e-14	Over
KIRC	Kidney renal clear cell carcinoma	72	534	7.059	7.511	0.416	2.42e-12	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.68	7.265	0.546	9.86e-10	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.666	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.892	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.818	5.889	0.061	0.446	NS
LUAD	Lung adenocarcinoma	59	517	6.709	7.167	0.446	2.22e-11	NS
LUSC	Lung squamous cell carcinoma	51	501	6.569	8.058	1.506	1.6e-34	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.948	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.956	6.918	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.818	6.515	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.243	7.604	0.426	5.05e-07	NS
READ	Rectum adenocarcinoma	10	167	6.996	7.063	-0.041	0.867	NS
SARC	Sarcoma	2	263	6.5	6.649	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.988	6.596	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.6	7.342	0.745	1.37e-11	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.985	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.575	7.545	-0.086	0.0728	NS
THYM	Thymoma	2	120	7.548	7.462	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.913	6.994	0.114	0.392	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.8
Autonomic ganglia	CHP212	9.2
Autonomic ganglia	IMR32	9.4
Autonomic ganglia	KELLY	9.5
Autonomic ganglia	KPNRTBM1	9.4
Autonomic ganglia	KPNSI9S	9
Autonomic ganglia	KPNYN	9
Autonomic ganglia	MHHNB11	10
Autonomic ganglia	NB1	10.1
Autonomic ganglia	NH6	9.1
Autonomic ganglia	SHSY5Y	9.7
Autonomic ganglia	SIMA	10.3
Autonomic ganglia	SKNAS	9.4
Autonomic ganglia	SKNBE2	9.2
Autonomic ganglia	SKNDZ	9.4
Autonomic ganglia	SKNFI	9.1
Autonomic ganglia	SKNSH	8.8
Biliary tract	HUCCT1	9.6
Biliary tract	HUH28	9
Biliary tract	SNU1079	9.9
Biliary tract	SNU1196	9.8
Biliary tract	SNU245	9.6
Biliary tract	SNU308	10.1
Biliary tract	SNU478	9.4
Bone	143B	9.2
Bone	A673	9.9
Bone	CADOES1	10.3
Bone	CAL78	10
Bone	G292CLONEA141B1	9.5
Bone	HOS	9
Bone	HS706T	9.4
Bone	HS737T	9.4
Bone	HS819T	9.4
Bone	HS821T	9.8
Bone	HS822T	9.2
Bone	HS863T	10.2
Bone	HS870T	9.1
Bone	HS888T	10.1
Bone	MG63	9.5
Bone	MHHES1	10.5
Bone	OUMS27	8.4
Bone	RDES	9.4
Bone	SJSA1	8.7
Bone	SKES1	9.7
Bone	SKNMC	10
Bone	SW1353	9.3
Bone	T173	8.9
Bone	TC71	9.2
Bone	U2OS	8.7
Breast	AU565	9.9
Breast	BT20	10
Breast	BT474	10
Breast	BT483	10.4
Breast	BT549	8.8
Breast	CAL120	9.5
Breast	CAL148	9.3
Breast	CAL51	9.7
Breast	CAL851	10.2
Breast	CAMA1	9.6
Breast	DU4475	9.5
Breast	EFM192A	9.4
Breast	EFM19	10.3
Breast	EVSAT	9.1
Breast	HCC1143	9.9
Breast	HCC1187	10
Breast	HCC1395	9.7
Breast	HCC1419	10.4
Breast	HCC1428	10.3
Breast	HCC1500	10.7
Breast	HCC1569	10.4
Breast	HCC1599	10.8
Breast	HCC1806	10
Breast	HCC1937	10.2
Breast	HCC1954	9.8
Breast	HCC202	9.4
Breast	HCC2157	9.3
Breast	HCC2218	8.9
Breast	HCC38	10
Breast	HCC70	10.3
Breast	HDQP1	10.1
Breast	HMC18	9.5
Breast	HS274T	9.9
Breast	HS281T	9.6
Breast	HS343T	9.6
Breast	HS578T	9.5
Breast	HS606T	9
Breast	HS739T	8.9
Breast	HS742T	8.9
Breast	JIMT1	9.8
Breast	KPL1	8.9
Breast	MCF7	8.2
Breast	MDAMB134VI	10.1
Breast	MDAMB157	9.1
Breast	MDAMB175VII	9.1
Breast	MDAMB231	9.1
Breast	MDAMB361	9.9
Breast	MDAMB415	9.7
Breast	MDAMB436	8.7
Breast	MDAMB453	10.4
Breast	MDAMB468	9.6
Breast	SKBR3	9.4
Breast	T47D	9.7
Breast	UACC812	8.9
Breast	UACC893	9.4
Breast	YMB1	8.9
Breast	ZR751	9.2
Breast	ZR7530	10.6
Central nervous system	1321N1	9.7
Central nervous system	42MGBA	9
Central nervous system	8MGBA	10.1
Central nervous system	A172	9
Central nervous system	AM38	8.8
Central nervous system	BECKER	9.2
Central nervous system	CAS1	9.4
Central nervous system	CCFSTTG1	9.2
Central nervous system	D283MED	10.1
Central nervous system	D341MED	9.2
Central nervous system	DAOY	10
Central nervous system	DBTRG05MG	9.3
Central nervous system	DKMG	10.1
Central nervous system	GAMG	9.2
Central nervous system	GB1	9.9
Central nervous system	GI1	9.5
Central nervous system	GMS10	8.9
Central nervous system	GOS3	9.4
Central nervous system	H4	9.7
Central nervous system	HS683	9.4
Central nervous system	KALS1	9.1
Central nervous system	KG1C	9
Central nervous system	KNS42	10
Central nervous system	KNS60	9.3
Central nervous system	KNS81	9.1
Central nervous system	KS1	9.3
Central nervous system	LN18	8.9
Central nervous system	LN229	9
Central nervous system	M059K	8.7
Central nervous system	MOGGCCM	9.9
Central nervous system	MOGGUVW	9.7
Central nervous system	NMCG1	8.9
Central nervous system	ONS76	9.7
Central nervous system	SF126	9.3
Central nervous system	SF295	9.1
Central nervous system	SNB19	9.3
Central nervous system	SNU1105	9.3
Central nervous system	SNU201	9.4
Central nervous system	SNU466	9.1
Central nervous system	SNU489	9.9
Central nervous system	SNU626	8.8
Central nervous system	SNU738	8.9
Central nervous system	SW1088	8.8
Central nervous system	SW1783	9.2
Central nervous system	T98G	9.9
Central nervous system	TM31	9.2
Central nervous system	U118MG	9.8
Central nervous system	U138MG	9.5
Central nervous system	U251MG	9.1
Central nervous system	U87MG	8.6
Central nervous system	YH13	9.9
Central nervous system	YKG1	9.5
Endometrium	AN3CA	8
Endometrium	COLO684	9.9
Endometrium	EFE184	10.3
Endometrium	EN	10.4
Endometrium	ESS1	10.5
Endometrium	HEC108	9.3
Endometrium	HEC151	9
Endometrium	HEC1A	9.3
Endometrium	HEC1B	9.6
Endometrium	HEC251	10.8
Endometrium	HEC265	9.9
Endometrium	HEC50B	9.9
Endometrium	HEC59	10
Endometrium	HEC6	9.8
Endometrium	ISHIKAWAHERAKLIO02ER	10.5
Endometrium	JHUEM1	9.8
Endometrium	JHUEM2	8.7
Endometrium	JHUEM3	10.8
Endometrium	KLE	8.3
Endometrium	MFE280	10.7
Endometrium	MFE296	9.2
Endometrium	MFE319	8.6
Endometrium	RL952	8.8
Endometrium	SNGM	8.7
Endometrium	SNU1077	9.6
Endometrium	SNU685	9.8
Endometrium	TEN	10.6
Haematopoietic and lymphoid	697	10.8
Haematopoietic and lymphoid	A3KAW	10.9
Haematopoietic and lymphoid	A4FUK	10
Haematopoietic and lymphoid	ALLSIL	9.6
Haematopoietic and lymphoid	AML193	10.7
Haematopoietic and lymphoid	AMO1	9.7
Haematopoietic and lymphoid	BCP1	9.1
Haematopoietic and lymphoid	BDCM	9
Haematopoietic and lymphoid	BL41	10.6
Haematopoietic and lymphoid	BL70	10.3
Haematopoietic and lymphoid	BV173	10
Haematopoietic and lymphoid	CA46	10.8
Haematopoietic and lymphoid	CI1	9.4
Haematopoietic and lymphoid	CMK115	9.3
Haematopoietic and lymphoid	CMK86	10.1
Haematopoietic and lymphoid	CMK	9.3
Haematopoietic and lymphoid	CMLT1	10.2
Haematopoietic and lymphoid	COLO775	11
Haematopoietic and lymphoid	DAUDI	10.2
Haematopoietic and lymphoid	DB	9.2
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	9.8
Haematopoietic and lymphoid	DOHH2	10
Haematopoietic and lymphoid	EB1	8.8
Haematopoietic and lymphoid	EB2	9.3
Haematopoietic and lymphoid	EHEB	8.8
Haematopoietic and lymphoid	EJM	10.2
Haematopoietic and lymphoid	EM2	10.6
Haematopoietic and lymphoid	EOL1	9.1
Haematopoietic and lymphoid	F36P	9.9
Haematopoietic and lymphoid	GA10	9.7
Haematopoietic and lymphoid	GDM1	9.5
Haematopoietic and lymphoid	GRANTA519	9.3
Haematopoietic and lymphoid	HDLM2	10.3
Haematopoietic and lymphoid	HDMYZ	9
Haematopoietic and lymphoid	HEL9217	9.6
Haematopoietic and lymphoid	HEL	9.5
Haematopoietic and lymphoid	HH	10.5
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	9.6
Haematopoietic and lymphoid	HS604T	10.6
Haematopoietic and lymphoid	HS611T	8.7
Haematopoietic and lymphoid	HS616T	9.1
Haematopoietic and lymphoid	HS751T	9.9
Haematopoietic and lymphoid	HT	9.5
Haematopoietic and lymphoid	HTK	10.2
Haematopoietic and lymphoid	HUNS1	8.7
Haematopoietic and lymphoid	HUT102	9
Haematopoietic and lymphoid	HUT78	9.2
Haematopoietic and lymphoid	JEKO1	9.2
Haematopoietic and lymphoid	JK1	9.4
Haematopoietic and lymphoid	JM1	9.8
Haematopoietic and lymphoid	JURKAT	10.9
Haematopoietic and lymphoid	JURLMK1	9.3
Haematopoietic and lymphoid	JVM2	10
Haematopoietic and lymphoid	JVM3	9.6
Haematopoietic and lymphoid	K562	9.4
Haematopoietic and lymphoid	KARPAS299	10.1
Haematopoietic and lymphoid	KARPAS422	8.8
Haematopoietic and lymphoid	KARPAS620	10.4
Haematopoietic and lymphoid	KASUMI1	11.1
Haematopoietic and lymphoid	KASUMI2	10.3
Haematopoietic and lymphoid	KASUMI6	10.4
Haematopoietic and lymphoid	KCL22	10.4
Haematopoietic and lymphoid	KE37	9.7
Haematopoietic and lymphoid	KE97	9.1
Haematopoietic and lymphoid	KG1	9.6
Haematopoietic and lymphoid	KHM1B	9.9
Haematopoietic and lymphoid	KIJK	9.3
Haematopoietic and lymphoid	KMH2	9.8
Haematopoietic and lymphoid	KMM1	9.6
Haematopoietic and lymphoid	KMS11	10.2
Haematopoietic and lymphoid	KMS12BM	10.3
Haematopoietic and lymphoid	KMS18	9.2
Haematopoietic and lymphoid	KMS20	10.6
Haematopoietic and lymphoid	KMS21BM	9.5
Haematopoietic and lymphoid	KMS26	9.6
Haematopoietic and lymphoid	KMS27	8.7
Haematopoietic and lymphoid	KMS28BM	10
Haematopoietic and lymphoid	KMS34	10
Haematopoietic and lymphoid	KO52	9.7
Haematopoietic and lymphoid	KOPN8	9.3
Haematopoietic and lymphoid	KU812	9.8
Haematopoietic and lymphoid	KYO1	9
Haematopoietic and lymphoid	L1236	9.8
Haematopoietic and lymphoid	L363	11.4
Haematopoietic and lymphoid	L428	10.1
Haematopoietic and lymphoid	L540	9.3
Haematopoietic and lymphoid	LAMA84	8.9
Haematopoietic and lymphoid	LOUCY	9.9
Haematopoietic and lymphoid	LP1	10.3
Haematopoietic and lymphoid	M07E	10.2
Haematopoietic and lymphoid	MC116	10.3
Haematopoietic and lymphoid	ME1	9.1
Haematopoietic and lymphoid	MEC1	10.6
Haematopoietic and lymphoid	MEC2	10.1
Haematopoietic and lymphoid	MEG01	9.4
Haematopoietic and lymphoid	MHHCALL2	10.8
Haematopoietic and lymphoid	MHHCALL3	10.3
Haematopoietic and lymphoid	MHHCALL4	10
Haematopoietic and lymphoid	MINO	9.6
Haematopoietic and lymphoid	MJ	9.7
Haematopoietic and lymphoid	MM1S	11
Haematopoietic and lymphoid	MOLM13	9.6
Haematopoietic and lymphoid	MOLM16	10.2
Haematopoietic and lymphoid	MOLM6	9.5
Haematopoietic and lymphoid	MOLP2	9.4
Haematopoietic and lymphoid	MOLP8	10.1
Haematopoietic and lymphoid	MOLT13	10.4
Haematopoietic and lymphoid	MOLT16	10.7
Haematopoietic and lymphoid	MOLT4	9.8
Haematopoietic and lymphoid	MONOMAC1	9.9
Haematopoietic and lymphoid	MONOMAC6	9.6
Haematopoietic and lymphoid	MOTN1	8.2
Haematopoietic and lymphoid	MUTZ5	9.6
Haematopoietic and lymphoid	MV411	10
Haematopoietic and lymphoid	NALM19	9.7
Haematopoietic and lymphoid	NALM1	9.7
Haematopoietic and lymphoid	NALM6	9.9
Haematopoietic and lymphoid	NAMALWA	10.3
Haematopoietic and lymphoid	NB4	10.2
Haematopoietic and lymphoid	NCIH929	9.3
Haematopoietic and lymphoid	NCO2	9.5
Haematopoietic and lymphoid	NOMO1	10.4
Haematopoietic and lymphoid	NUDHL1	8.6
Haematopoietic and lymphoid	NUDUL1	9.6
Haematopoietic and lymphoid	OCIAML2	10.1
Haematopoietic and lymphoid	OCIAML3	9.3
Haematopoietic and lymphoid	OCIAML5	9.8
Haematopoietic and lymphoid	OCILY10	8.9
Haematopoietic and lymphoid	OCILY19	9.2
Haematopoietic and lymphoid	OCILY3	10
Haematopoietic and lymphoid	OCIM1	9.9
Haematopoietic and lymphoid	OPM2	10.6
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	9.4
Haematopoietic and lymphoid	P3HR1	9
Haematopoietic and lymphoid	PCM6	9.6
Haematopoietic and lymphoid	PEER	9.7
Haematopoietic and lymphoid	PF382	9.5
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	9.4
Haematopoietic and lymphoid	RAJI	9.8
Haematopoietic and lymphoid	RCHACV	11
Haematopoietic and lymphoid	REC1	10
Haematopoietic and lymphoid	REH	9.5
Haematopoietic and lymphoid	RI1	9.9
Haematopoietic and lymphoid	RL	9.8
Haematopoietic and lymphoid	RPMI8226	10.6
Haematopoietic and lymphoid	RPMI8402	10.7
Haematopoietic and lymphoid	RS411	9.9
Haematopoietic and lymphoid	SEM	9.8
Haematopoietic and lymphoid	SET2	9.4
Haematopoietic and lymphoid	SIGM5	10.5
Haematopoietic and lymphoid	SKM1	9.7
Haematopoietic and lymphoid	SKMM2	10
Haematopoietic and lymphoid	SR786	9.7
Haematopoietic and lymphoid	ST486	10.2
Haematopoietic and lymphoid	SUDHL10	9.6
Haematopoietic and lymphoid	SUDHL1	10.2
Haematopoietic and lymphoid	SUDHL4	9.6
Haematopoietic and lymphoid	SUDHL5	10
Haematopoietic and lymphoid	SUDHL6	11.1
Haematopoietic and lymphoid	SUDHL8	9.3
Haematopoietic and lymphoid	SUPB15	9.5
Haematopoietic and lymphoid	SUPHD1	9.9
Haematopoietic and lymphoid	SUPM2	9.2
Haematopoietic and lymphoid	SUPT11	9.4
Haematopoietic and lymphoid	SUPT1	9.4
Haematopoietic and lymphoid	TALL1	9.5
Haematopoietic and lymphoid	TF1	10.2
Haematopoietic and lymphoid	THP1	9.7
Haematopoietic and lymphoid	TO175T	9.2
Haematopoietic and lymphoid	TOLEDO	9.5
Haematopoietic and lymphoid	U266B1	9.6
Haematopoietic and lymphoid	U937	9.5
Haematopoietic and lymphoid	UT7	8.8
Haematopoietic and lymphoid	WSUDLCL2	10.2
Kidney	769P	9.1
Kidney	786O	9.8
Kidney	A498	10.1
Kidney	A704	10.5
Kidney	ACHN	9.1
Kidney	BFTC909	10.8
Kidney	CAKI1	9.7
Kidney	CAKI2	10.2
Kidney	CAL54	9.6
Kidney	KMRC1	10.7
Kidney	KMRC20	10.2
Kidney	KMRC2	9.9
Kidney	KMRC3	8.6
Kidney	OSRC2	10
Kidney	RCC10RGB	9.8
Kidney	SNU1272	9.6
Kidney	SNU349	10.1
Kidney	TUHR10TKB	10
Kidney	TUHR14TKB	10.2
Kidney	TUHR4TKB	9.9
Kidney	VMRCRCW	10.4
Kidney	VMRCRCZ	9.5
Large intestine	C2BBE1	8.8
Large intestine	CCK81	9.4
Large intestine	CL11	10.1
Large intestine	CL14	8.8
Large intestine	CL34	10.2
Large intestine	CL40	9.2
Large intestine	COLO205	9.3
Large intestine	COLO320	11.1
Large intestine	COLO678	9.9
Large intestine	CW2	9.1
Large intestine	DLD1	9.7
Large intestine	GP2D	10.1
Large intestine	HCC56	9.7
Large intestine	HCT116	9.4
Large intestine	HCT15	9
Large intestine	HS675T	8.7
Large intestine	HS698T	9.2
Large intestine	HT115	9.8
Large intestine	HT29	9.9
Large intestine	HT55	10
Large intestine	KM12	10.2
Large intestine	LOVO	9.5
Large intestine	LS1034	9.4
Large intestine	LS123	9.2
Large intestine	LS180	9.5
Large intestine	LS411N	8.9
Large intestine	LS513	9.7
Large intestine	MDST8	9.2
Large intestine	NCIH508	10.2
Large intestine	NCIH716	9.2
Large intestine	NCIH747	9.8
Large intestine	OUMS23	9.1
Large intestine	RCM1	10
Large intestine	RKO	9.6
Large intestine	SKCO1	9.9
Large intestine	SNU1040	9.6
Large intestine	SNU1197	9.8
Large intestine	SNU175	10.4
Large intestine	SNU283	10.1
Large intestine	SNU407	10.1
Large intestine	SNU503	10.9
Large intestine	SNU61	10
Large intestine	SNU81	9.7
Large intestine	SNUC1	9.7
Large intestine	SNUC2A	9
Large intestine	SNUC4	10.2
Large intestine	SNUC5	9.8
Large intestine	SW1116	9.5
Large intestine	SW1417	9
Large intestine	SW1463	9.2
Large intestine	SW403	9.5
Large intestine	SW480	9.8
Large intestine	SW48	9.5
Large intestine	SW620	9.6
Large intestine	SW837	9.9
Large intestine	SW948	9.1
Large intestine	T84	9.8
Liver	ALEXANDERCELLS	8
Liver	C3A	8.1
Liver	HEP3B217	9.7
Liver	HEPG2	8.7
Liver	HLE	8.8
Liver	HLF	8.1
Liver	HUH1	9.1
Liver	HUH6	9.5
Liver	HUH7	8.7
Liver	JHH1	9.9
Liver	JHH2	9.5
Liver	JHH4	8.9
Liver	JHH5	9.1
Liver	JHH6	9.6
Liver	JHH7	9.3
Liver	LI7	9.5
Liver	PLCPRF5	7.7
Liver	SKHEP1	9.6
Liver	SNU182	8.5
Liver	SNU387	9.9
Liver	SNU398	9.1
Liver	SNU423	9.1
Liver	SNU449	8.6
Liver	SNU475	9.5
Liver	SNU761	9.3
Liver	SNU878	9.8
Liver	SNU886	9.9
Lung	A549	8.6
Lung	ABC1	9.7
Lung	BEN	9.9
Lung	CAL12T	9.2
Lung	CALU1	9.4
Lung	CALU3	10.4
Lung	CALU6	9.4
Lung	CHAGOK1	10
Lung	COLO668	9.4
Lung	COLO699	9.3
Lung	CORL105	8.8
Lung	CORL23	9.7
Lung	CORL24	10.5
Lung	CORL279	9.6
Lung	CORL311	10
Lung	CORL47	10
Lung	CORL51	10.3
Lung	CORL88	11
Lung	CORL95	4.4
Lung	CPCN	9.5
Lung	DMS114	9.3
Lung	DMS153	9.7
Lung	DMS273	10.2
Lung	DMS454	10.4
Lung	DMS53	8.7
Lung	DMS79	9.3
Lung	DV90	9
Lung	EBC1	9.2
Lung	EPLC272H	9.3
Lung	HARA	10.4
Lung	HCC1171	9.9
Lung	HCC1195	9.3
Lung	HCC15	7.8
Lung	HCC2279	9.5
Lung	HCC2935	10.6
Lung	HCC33	10.2
Lung	HCC366	10.1
Lung	HCC4006	10.2
Lung	HCC44	9.6
Lung	HCC78	9.9
Lung	HCC827	9.6
Lung	HCC95	11.6
Lung	HLC1	9.8
Lung	HLFA	8.8
Lung	HS229T	9
Lung	HS618T	8.6
Lung	IALM	9.3
Lung	KNS62	10.5
Lung	LC1F	10.3
Lung	LC1SQSF	11.4
Lung	LCLC103H	9.4
Lung	LCLC97TM1	11.2
Lung	LK2	10.1
Lung	LOUNH91	8.5
Lung	LU65	9.4
Lung	LU99	9.1
Lung	LUDLU1	10.1
Lung	LXF289	9
Lung	MORCPR	9
Lung	NCIH1048	9.2
Lung	NCIH1092	10.5
Lung	NCIH1105	10.3
Lung	NCIH1155	9.3
Lung	NCIH1184	9.3
Lung	NCIH1299	8.9
Lung	NCIH1339	9.5
Lung	NCIH1341	9.3
Lung	NCIH1355	8.7
Lung	NCIH1373	10
Lung	NCIH1385	9
Lung	NCIH1395	8.3
Lung	NCIH1435	8.9
Lung	NCIH1436	10.5
Lung	NCIH1437	10.5
Lung	NCIH146	9.2
Lung	NCIH1563	9.4
Lung	NCIH1568	9.3
Lung	NCIH1573	8.8
Lung	NCIH1581	9.4
Lung	NCIH1618	9.1
Lung	NCIH1623	9.7
Lung	NCIH1648	10.3
Lung	NCIH1650	9.2
Lung	NCIH1651	9.6
Lung	NCIH1666	9.8
Lung	NCIH1693	8.9
Lung	NCIH1694	9
Lung	NCIH1703	8.9
Lung	NCIH1734	9.5
Lung	NCIH1755	9.4
Lung	NCIH1781	9.8
Lung	NCIH1792	9.7
Lung	NCIH1793	10.1
Lung	NCIH1836	9.5
Lung	NCIH1838	8.8
Lung	NCIH1869	9.8
Lung	NCIH1876	9.7
Lung	NCIH1915	9.6
Lung	NCIH1930	8.4
Lung	NCIH1944	9.8
Lung	NCIH1963	9.1
Lung	NCIH196	9.6
Lung	NCIH1975	9.7
Lung	NCIH2009	10.3
Lung	NCIH2023	9
Lung	NCIH2029	9.8
Lung	NCIH2030	8.9
Lung	NCIH2066	8.6
Lung	NCIH2081	10.3
Lung	NCIH2085	9.2
Lung	NCIH2087	9.6
Lung	NCIH209	8.5
Lung	NCIH2106	9.2
Lung	NCIH2110	10.3
Lung	NCIH211	9.5
Lung	NCIH2122	9.3
Lung	NCIH2126	9.1
Lung	NCIH2141	9.5
Lung	NCIH2170	9.7
Lung	NCIH2171	9.6
Lung	NCIH2172	8.9
Lung	NCIH2196	10.5
Lung	NCIH2227	9.1
Lung	NCIH2228	10.4
Lung	NCIH226	8.9
Lung	NCIH2286	9.5
Lung	NCIH2291	9.6
Lung	NCIH2342	10.3
Lung	NCIH2347	10
Lung	NCIH23	8.7
Lung	NCIH2405	10.2
Lung	NCIH2444	10
Lung	NCIH292	9.5
Lung	NCIH322	9.1
Lung	NCIH3255	11.1
Lung	NCIH358	10.5
Lung	NCIH441	11.1
Lung	NCIH446	9.7
Lung	NCIH460	8.6
Lung	NCIH510	9.2
Lung	NCIH520	10.2
Lung	NCIH522	8.9
Lung	NCIH524	9.9
Lung	NCIH526	9.7
Lung	NCIH596	9.6
Lung	NCIH647	9.2
Lung	NCIH650	8.9
Lung	NCIH661	8.2
Lung	NCIH69	9.2
Lung	NCIH727	10.1
Lung	NCIH810	10.1
Lung	NCIH82	10.4
Lung	NCIH838	9.6
Lung	NCIH841	10.2
Lung	NCIH854	9.2
Lung	NCIH889	9.6
Lung	PC14	9.7
Lung	RERFLCAD1	9.9
Lung	RERFLCAD2	9.2
Lung	RERFLCAI	8.8
Lung	RERFLCKJ	9.1
Lung	RERFLCMS	9
Lung	RERFLCSQ1	10.9
Lung	SBC5	9.3
Lung	SCLC21H	9.3
Lung	SHP77	10
Lung	SKLU1	8.8
Lung	SKMES1	8.6
Lung	SQ1	10.6
Lung	SW1271	9.6
Lung	SW1573	9.5
Lung	SW900	9
Lung	VMRCLCD	10.6
Lung	VMRCLCP	10.9
Oesophagus	COLO680N	9.3
Oesophagus	ECGI10	10.3
Oesophagus	KYSE140	10.8
Oesophagus	KYSE150	9.9
Oesophagus	KYSE180	10.8
Oesophagus	KYSE270	11.3
Oesophagus	KYSE30	9.2
Oesophagus	KYSE410	10.1
Oesophagus	KYSE450	10.7
Oesophagus	KYSE510	9.9
Oesophagus	KYSE520	9.6
Oesophagus	KYSE70	9.3
Oesophagus	OE19	9.8
Oesophagus	OE33	10.4
Oesophagus	TE10	10.2
Oesophagus	TE11	10.3
Oesophagus	TE14	10.2
Oesophagus	TE15	9.8
Oesophagus	TE1	9.4
Oesophagus	TE4	9.6
Oesophagus	TE5	9.5
Oesophagus	TE6	10.4
Oesophagus	TE8	9.5
Oesophagus	TE9	10
Oesophagus	TT	10.9
Ovary	59M	9.8
Ovary	A2780	9.4
Ovary	CAOV3	9.2
Ovary	CAOV4	9.7
Ovary	COLO704	9.4
Ovary	COV318	9.3
Ovary	COV362	10.9
Ovary	COV434	9.3
Ovary	COV504	10
Ovary	COV644	9.2
Ovary	EFO21	10.3
Ovary	EFO27	9.4
Ovary	ES2	9.2
Ovary	FUOV1	9.8
Ovary	HEYA8	10
Ovary	HS571T	9.1
Ovary	IGROV1	9.3
Ovary	JHOC5	10
Ovary	JHOM1	9.8
Ovary	JHOM2B	10.3
Ovary	JHOS2	11.5
Ovary	JHOS4	9.2
Ovary	KURAMOCHI	11.1
Ovary	MCAS	9.4
Ovary	NIHOVCAR3	10.4
Ovary	OAW28	11.4
Ovary	OAW42	10
Ovary	OC314	9.3
Ovary	OC316	9
Ovary	ONCODG1	10.4
Ovary	OV56	9.2
Ovary	OV7	4.7
Ovary	OV90	10
Ovary	OVCAR4	9.4
Ovary	OVCAR8	9.6
Ovary	OVISE	9.9
Ovary	OVK18	9.1
Ovary	OVKATE	11.7
Ovary	OVMANA	10.7
Ovary	OVSAHO	10
Ovary	OVTOKO	9.8
Ovary	RMGI	9.9
Ovary	RMUGS	8.6
Ovary	SKOV3	10
Ovary	SNU119	11.5
Ovary	SNU840	9.6
Ovary	SNU8	9.5
Ovary	TOV112D	9.3
Ovary	TOV21G	8.7
Ovary	TYKNU	9
Pancreas	ASPC1	9
Pancreas	BXPC3	9.6
Pancreas	CAPAN1	11.1
Pancreas	CAPAN2	9.8
Pancreas	CFPAC1	10.2
Pancreas	DANG	9.8
Pancreas	HPAC	10
Pancreas	HPAFII	9.6
Pancreas	HS766T	8.7
Pancreas	HUPT3	9.3
Pancreas	HUPT4	9.9
Pancreas	KCIMOH1	9.6
Pancreas	KLM1	10.1
Pancreas	KP2	10.3
Pancreas	KP3	9
Pancreas	KP4	9.5
Pancreas	L33	9.4
Pancreas	MIAPACA2	9.1
Pancreas	PANC0203	10.4
Pancreas	PANC0213	10.3
Pancreas	PANC0327	9.9
Pancreas	PANC0403	9.6
Pancreas	PANC0504	9.5
Pancreas	PANC0813	9.9
Pancreas	PANC1005	9.9
Pancreas	PANC1	9.4
Pancreas	PATU8902	10
Pancreas	PATU8988S	10
Pancreas	PATU8988T	9.3
Pancreas	PK1	9.5
Pancreas	PK45H	9.7
Pancreas	PK59	9
Pancreas	PL45	9.5
Pancreas	PSN1	9.5
Pancreas	QGP1	9.8
Pancreas	SNU213	10.2
Pancreas	SNU324	10.4
Pancreas	SNU410	9.6
Pancreas	SU8686	9.6
Pancreas	SUIT2	10.3
Pancreas	SW1990	9.5
Pancreas	T3M4	9.5
Pancreas	TCCPAN2	10
Pancreas	YAPC	10.2
Pleura	ACCMESO1	9.2
Pleura	DM3	8.7
Pleura	ISTMES1	8.7
Pleura	ISTMES2	8.5
Pleura	JL1	9.6
Pleura	MPP89	9.1
Pleura	MSTO211H	9.3
Pleura	NCIH2052	8.5
Pleura	NCIH2452	9.2
Pleura	NCIH28	9.2
Prostate	22RV1	9.1
Prostate	DU145	9.4
Prostate	LNCAPCLONEFGC	11
Prostate	MDAPCA2B	8.4
Prostate	NCIH660	9.9
Prostate	PC3	9.3
Prostate	VCAP	9.9
Salivary gland	A253	10.6
Salivary gland	YD15	9.8
Skin	A101D	8.9
Skin	A2058	9.8
Skin	A375	8.9
Skin	C32	9
Skin	CHL1	9.4
Skin	CJM	10.2
Skin	COLO679	8.6
Skin	COLO741	9.4
Skin	COLO783	9.7
Skin	COLO792	9.9
Skin	COLO800	9.7
Skin	COLO818	9.5
Skin	COLO829	9.6
Skin	COLO849	10
Skin	G361	9.7
Skin	GRM	10.1
Skin	HMCB	9.9
Skin	HS294T	8.8
Skin	HS600T	8.9
Skin	HS688AT	9
Skin	HS695T	9.2
Skin	HS839T	8.7
Skin	HS852T	9.7
Skin	HS895T	9.1
Skin	HS934T	9.6
Skin	HS936T	8.9
Skin	HS939T	8.9
Skin	HS940T	8.9
Skin	HS944T	9.2
Skin	HT144	9.3
Skin	IGR1	9.8
Skin	IGR37	9.3
Skin	IGR39	9.5
Skin	IPC298	9.4
Skin	K029AX	8.6
Skin	LOXIMVI	9.7
Skin	MALME3M	9.2
Skin	MDAMB435S	10.2
Skin	MELHO	9.3
Skin	MELJUSO	9.1
Skin	MEWO	9.9
Skin	RPMI7951	9.9
Skin	RVH421	8.6
Skin	SH4	9.2
Skin	SKMEL1	8.8
Skin	SKMEL24	8.9
Skin	SKMEL28	9.3
Skin	SKMEL2	9.2
Skin	SKMEL30	9.3
Skin	SKMEL31	9
Skin	SKMEL3	8.7
Skin	SKMEL5	8.9
Skin	UACC257	8.6
Skin	UACC62	9.6
Skin	WM115	9.4
Skin	WM1799	9.9
Skin	WM2664	9.7
Skin	WM793	9.6
Skin	WM88	9.7
Skin	WM983B	10
Small intestine	HUTU80	9
Soft tissue	A204	9
Soft tissue	G401	9
Soft tissue	G402	8.6
Soft tissue	GCT	9.5
Soft tissue	HS729	8.7
Soft tissue	HT1080	9.5
Soft tissue	KYM1	9.1
Soft tissue	MESSA	8.9
Soft tissue	RD	9.5
Soft tissue	RH30	9.5
Soft tissue	RH41	10.1
Soft tissue	RKN	9
Soft tissue	S117	9.8
Soft tissue	SJRH30	9.7
Soft tissue	SKLMS1	8.9
Soft tissue	SKUT1	9.1
Soft tissue	TE125T	10
Soft tissue	TE159T	9
Soft tissue	TE441T	9.7
Soft tissue	TE617T	8.3
Stomach	2313287	10.1
Stomach	AGS	9.3
Stomach	AZ521	9.2
Stomach	ECC10	10.7
Stomach	ECC12	11.3
Stomach	FU97	9.9
Stomach	GCIY	8.6
Stomach	GSS	9.6
Stomach	GSU	9.9
Stomach	HGC27	8.9
Stomach	HS746T	8.9
Stomach	HUG1N	10.1
Stomach	IM95	10.2
Stomach	KATOIII	9.7
Stomach	KE39	9.2
Stomach	LMSU	10
Stomach	MKN1	8.9
Stomach	MKN45	10.2
Stomach	MKN74	9.3
Stomach	MKN7	9.3
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	10.1
Stomach	NUGC2	8.9
Stomach	NUGC3	9
Stomach	NUGC4	9.2
Stomach	OCUM1	9.1
Stomach	RERFGC1B	9.4
Stomach	SH10TC	9.4
Stomach	SNU16	10
Stomach	SNU1	9.2
Stomach	SNU216	10.7
Stomach	SNU520	9.5
Stomach	SNU5	9.4
Stomach	SNU601	10.2
Stomach	SNU620	9.6
Stomach	SNU668	8
Stomach	SNU719	10.4
Stomach	TGBC11TKB	9.6
Thyroid	8305C	9.7
Thyroid	8505C	9.7
Thyroid	BCPAP	10.2
Thyroid	BHT101	10.5
Thyroid	CAL62	10
Thyroid	CGTHW1	9.6
Thyroid	FTC133	9.6
Thyroid	FTC238	10.5
Thyroid	ML1	10.7
Thyroid	SW579	9.2
Thyroid	TT2609C02	10.1
Thyroid	TT	9.4
Upper aerodigestive tract	BHY	9
Upper aerodigestive tract	BICR16	9.8
Upper aerodigestive tract	BICR18	10.7
Upper aerodigestive tract	BICR22	11.8
Upper aerodigestive tract	BICR31	10.7
Upper aerodigestive tract	BICR56	10.6
Upper aerodigestive tract	BICR6	10.3
Upper aerodigestive tract	CAL27	10
Upper aerodigestive tract	CAL33	10.9
Upper aerodigestive tract	DETROIT562	10.2
Upper aerodigestive tract	FADU	10.7
Upper aerodigestive tract	HS840T	8.8
Upper aerodigestive tract	HSC2	9.5
Upper aerodigestive tract	HSC3	9.6
Upper aerodigestive tract	HSC4	9.7
Upper aerodigestive tract	PECAPJ15	10.9
Upper aerodigestive tract	PECAPJ34CLONEC12	10.9
Upper aerodigestive tract	PECAPJ41CLONED2	10.3
Upper aerodigestive tract	PECAPJ49	10
Upper aerodigestive tract	SCC15	10.1
Upper aerodigestive tract	SCC25	10.1
Upper aerodigestive tract	SCC4	9.3
Upper aerodigestive tract	SCC9	9.5
Upper aerodigestive tract	SNU1076	10.1
Upper aerodigestive tract	SNU1214	10.1
Upper aerodigestive tract	SNU46	9.3
Upper aerodigestive tract	SNU899	10.5
Upper aerodigestive tract	YD10B	9.9
Upper aerodigestive tract	YD38	9.9
Upper aerodigestive tract	YD8	9.2
Urinary tract	5637	8.7
Urinary tract	639V	9.8
Urinary tract	647V	9.7
Urinary tract	BC3C	10.5
Urinary tract	BFTC905	11.4
Urinary tract	CAL29	9.6
Urinary tract	HS172T	8.1
Urinary tract	HT1197	10
Urinary tract	HT1376	9.3
Urinary tract	J82	9
Urinary tract	JMSU1	9.6
Urinary tract	KMBC2	9.7
Urinary tract	KU1919	10.2
Urinary tract	RT11284	10.6
Urinary tract	RT112	10.1
Urinary tract	RT4	9.3
Urinary tract	SCABER	9.5
Urinary tract	SW1710	9.4
Urinary tract	SW780	9.5
Urinary tract	T24	9.3
Urinary tract	TCCSUP	8.7
Urinary tract	UMUC1	10.4
Urinary tract	UMUC3	9.1
Urinary tract	VMCUB1	11.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	18.1
Adrenal gland	24.4
Appendix	27.1
Bone marrow	18
Breast	21.7
Cerebral cortex	36.6
Cervix, uterine	30.9
Colon	27.7
Duodenum	23.4
Endometrium	22.7
Epididymis	10.9
Esophagus	18.7
Fallopian tube	30.3
Gallbladder	30.8
Heart muscle	18
Kidney	18.7
Liver	10.2
Lung	24.7
Lymph node	27.9
Ovary	20.9
Pancreas	2.2
Parathyroid gland	41.8
Placenta	23.5
Prostate	33.3
Rectum	22.6
Salivary gland	6.3
Seminal vesicle	16
Skeletal muscle	3.3
Skin	16.4
Small intestine	17.3
Smooth muscle	23
Spleen	28
Stomach	17.6
Testis	30.2
Thyroid gland	61.2
Tonsil	29.2
Urinary bladder	32.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28344213	overexpression	Ovarian Carcinoma	Real-time quantitative PCR analysis showed that the expression level of TBL1XR1 mRNA was significantly higher in EOC tissues compared with adjacent non-tumorous tissues.
27694893	overexpression	Gastric Carcinoma	Here, we find that TBL1XR1 is aberrantly expressed in human GC tissues, and TBL1XR1 levels are highly correlated with local tumour invasion, late tumor, lymph node, metastasis (TNM) stage and poor prognosis.
27694893	Overexpression	Gastric Carcinoma	Here, we find that TBL1XR1 is aberrantly expressed in human GC tissues, and TBL1XR1 levels are highly correlated with local tumour invasion, late tumor, lymph node, metastasis (TNM) stage and poor prognosis.
27672238	Overexpression	Gastric Carcinoma	Analysis of GSE2701 showed that the mRNA levels of TBL1XR1 were significantly elevated in primary gastric tumor and lymph node tissues than normal gastric tissues (P < 0.05). 204 of 334 (60.1%) primary gastric cancer tissues showed high expression of TBL1XR1 protein.
27127173	Aberrant expression	Prostate Carcinoma	When comparing androgen-dependent (AD) to androgen-independent (AI) PCa, AI cells contain very high levels of TBLR1 cytoplasmic expression and low levels of nuclear expression. Additionally, we identified a cytoplasmic specific isoform of TBLR1 (cvTBLR1) approximately 5 kDa lower in molecular weight, that is expressed at higher levels in AI PCa cells.
26386862	Overexpression	Hepatocellular Carcinoma	TBLR1 mRNA in HCC tissue was markedly higher (P<0.001) than that in ANT. High expression of TBLR1 is closely related to serum alpha fetoprotein (P=0.047), BCLC stage (P<0.001), maximum size of tumors (P<0.001), tumor embolus (P<0.001), and histological grade (P<0.001).
25341494	Overexpression	Breast Carcinoma	TBLR1 was significantly upregulated in breast cancer cells and tissues compared to normal control samples. Immunohistochemical analysis revealed high expression of TBLR1 in 113 of 214 (52.8%) paraffin-embedded archival breast cancer.
25145705	Overexpression	Nasopharyngeal Carcinoma	Upregulation of TBL1XR1 induces NPC cells resistance to cisplatin by activating the NF-κB pathway, and correlates with poor overall survival of NPC patients.
24874481	Overexpression	Cervical Carcinoma	The expression of TBLR1 in cervical cancer cell lines and tissues was significantly upregulated at both the RNA and protein levels compared with that in normal cervical cells.
24667177	Overexpression	Oesophagal Squamous Cell Carcinoma	TBL1XR1 expression was significantly upregulated in ESCC, positively correlated with disease stage and patient survival, and identified as an independent prognostic factor for patient outcome.
24243687	Underexpression	Prostate Carcinoma	Similarly, in human tumor samples, the expression of TBLR1 in the nucleus is significantly reduced in the malignant glands compared with the surrounding benign prostatic glands (P<0.005).
18767146	Underexpression (copy number loss)	Lymphoblastic Leukemia	Focal deletions of TBL1XR1 were observed in 15% of cases; 3 patients exhibited deletions distal to the gene. Fluorescence in situ hybridization confirmed these deletions and quantitative RT-PCR showed that the TBL1XR1 gene was significantly under-expressed.
17316888	Overexpression	Lung Squamous Cell Carcinoma	The elevated mRNA expression of RAP2B, CLDN1 and TBL1XR1, three genes located on chromosome 3q, were further validated in 64.3% (18/28), 82.1% (23/28), and 75.0% (21/28) of lung SCC tumour tissues, respectively, by quantitative real-time reverse transcription-PCR analysis.

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.443	8.34e-21	3.5	42.8	53.7	Gain
BRCA	Breast invasive carcinoma	1075	0.396	1.16e-41	5.5	62.8	31.7	Neutral
CESC	Cervical and endocervical cancers	292	0.696	1.46e-43	1.4	22.6	76	Gain
COAD	Colon adenocarcinoma	449	0.303	5.13e-11	7.3	75.9	16.7	Neutral
ESCA	Esophageal carcinoma	183	0.716	4.43e-30	6	28.4	65.6	Gain
GBM	Glioblastoma multiforme	147	0.568	6.17e-14	5.4	72.8	21.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.754	1.34e-95	1.4	26.3	72.4	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.4	1.41e-21	11.8	71.8	16.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.371	8.17e-11	1.7	63.2	35.1	Gain
LAML	Acute Myeloid Leukemia	166	0.137	0.0775	1.8	97	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.102	0.0214	5.7	91.4	2.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.476	6.04e-22	11.8	70.9	17.3	Neutral
LUAD	Lung adenocarcinoma	512	0.505	1.79e-34	23.2	47.3	29.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.756	3.09e-93	0.6	9.4	90	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.556	1.03e-25	1	17.3	81.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.44	9.11e-10	10.2	74	15.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.59	1.49e-16	58	42	0	Loss
PRAD	Prostate adenocarcinoma	491	0.457	1.18e-26	4.3	80.9	14.9	Neutral
READ	Rectum adenocarcinoma	164	0.228	0.00339	5.5	71.3	23.2	Neutral
SARC	Sarcoma	255	0.459	1.01e-14	21.6	62.7	15.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.271	1.33e-07	16.6	63.5	19.9	Neutral
STAD	Stomach adenocarcinoma	413	0.432	3.4e-20	8	55.7	36.3	Gain
TGCT	Testicular Germ Cell Tumors	150	0.429	4.18e-08	12.7	56.7	30.7	Neutral
THCA	Thyroid carcinoma	497	0	1	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.099	0.286	5	90.8	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.595	1.16e-52	1.7	69.5	28.9	Neutral

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.453	0	17	408	-0.135	0.00369	NS/NA
BRCA	Breast invasive carcinoma	-0.347	0	83	785	-0.115	1.25e-16	NS/NA
CESC	Cervical and endocervical cancers	-0.492	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.334	1.41e-09	19	297	0.012	0.00328	NS/NA
ESCA	Esophageal carcinoma	-0.485	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.199	0.112	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.514	0	20	522	-0.032	9.81e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.134	0.0132	24	319	-0.011	7.63e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.242	2.47e-05	23	275	0.016	0.586	NS/NA
LAML	Acute Myeloid Leukemia	-0.258	0.000713	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.211	1.06e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.179	0.000247	41	373	0.06	6.56e-05	NS/NA
LUAD	Lung adenocarcinoma	-0.315	2.31e-12	21	456	-0.224	8.2e-15	Decreased
LUSC	Lung squamous cell carcinoma	-0.551	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.65	0.0666	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.341	2.6e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.381	9.87e-08	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.295	4.87e-12	35	498	-0.004	0.394	NS/NA
READ	Rectum adenocarcinoma	-0.303	0.00219	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.223	0.00027	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.217	2.07e-06	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.361	9.75e-13	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.475	5.58e-10	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.188	7.8e-06	50	509	-0.069	7.37e-08	NS/NA
THYM	Thymoma	-0.158	0.0819	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.412	0	34	431	-0.019	0.249	NS/NA

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.77	NS	24476821
BRCA	Breast invasive carcinoma	521	0.111	NS	23000897
COAD	Colon adenocarcinoma	149	0.0354	Significant	22810696
GBM	Glioblastoma multiforme	157	0.113	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.92e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.54	NS	26536169
LGG	Brain Lower Grade Glioma	513	7.57e-15	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000385	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	5.89e-12	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.126	NS	21720365
PRAD	Prostate adenocarcinoma	333	1.15e-06	Significant	26544944
READ	Rectum adenocarcinoma	67	0.234	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.311	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000156	Significant	25079317
THCA	Thyroid carcinoma	391	2.66e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	2.37e-11	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.848	0.433	NS
BRCA	Breast invasive carcinoma	1079	0.807	0.359	NS
CESC	Cervical and endocervical cancers	291	1.06	0.857	NS
COAD	Colon adenocarcinoma	439	0.748	0.326	NS
ESCA	Esophageal carcinoma	184	1.062	0.857	NS
GBM	Glioblastoma multiforme	158	0.321	1.94e-05	Longer
HNSC	Head and Neck squamous cell carcinoma	518	1.222	0.318	NS
KIRC	Kidney renal clear cell carcinoma	531	1.191	0.401	NS
KIRP	Kidney renal papillary cell carcinoma	287	3.397	0.0096	Shorter
LAML	Acute Myeloid Leukemia	149	0.621	0.0887	NS
LGG	Brain Lower Grade Glioma	511	0.694	0.143	NS
LIHC	Liver hepatocellular carcinoma	365	1.543	0.0777	NS
LUAD	Lung adenocarcinoma	502	1.608	0.0259	Shorter
LUSC	Lung squamous cell carcinoma	494	0.671	0.0341	Longer
OV	Ovarian serous cystadenocarcinoma	303	1.299	0.211	NS
PAAD	Pancreatic adenocarcinoma	177	2.829	0.000622	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	0.95	0.959	NS
PRAD	Prostate adenocarcinoma	497	0.346	0.338	NS
READ	Rectum adenocarcinoma	159	0.792	0.707	NS
SARC	Sarcoma	259	2.788	0.000989	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.661	0.0333	Longer
STAD	Stomach adenocarcinoma	388	1.183	0.447	NS
TGCT	Testicular Germ Cell Tumors	134	1241116842.127	0.234	NS
THCA	Thyroid carcinoma	500	0.536	0.489	NS
THYM	Thymoma	119	0.649	0.636	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	3.078	0.000111	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.025	0.617	NS
BRCA	Breast invasive carcinoma	1071	-0.05	0.0994	NS
CESC	Cervical and endocervical cancers	167	-0.065	0.407	NS
COAD	Colon adenocarcinoma	445	-0.049	0.304	NS
ESCA	Esophageal carcinoma	162	-0.014	0.859	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.078	0.099	NS
KIRC	Kidney renal clear cell carcinoma	531	0.081	0.0617	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.189	0.00225	Higher
LIHC	Liver hepatocellular carcinoma	347	0.126	0.0193	Higher
LUAD	Lung adenocarcinoma	507	0.025	0.567	NS
LUSC	Lung squamous cell carcinoma	497	0.022	0.625	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.063	0.279	NS
PAAD	Pancreatic adenocarcinoma	176	0.186	0.0136	Higher
READ	Rectum adenocarcinoma	156	0.019	0.815	NS
SKCM	Skin Cutaneous Melanoma	410	0.002	0.97	NS
STAD	Stomach adenocarcinoma	392	0.06	0.233	NS
TGCT	Testicular Germ Cell Tumors	81	0.355	0.00116	Higher
THCA	Thyroid carcinoma	499	-0.016	0.719	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.215	1.17e-06	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.12	0.0481	Lower
HNSC	Head and Neck squamous cell carcinoma	498	0.026	0.557	NS
KIRC	Kidney renal clear cell carcinoma	525	0.002	0.958	NS
LGG	Brain Lower Grade Glioma	514	-0.061	0.165	NS
LIHC	Liver hepatocellular carcinoma	366	0.162	0.00183	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.009	0.876	NS
PAAD	Pancreatic adenocarcinoma	176	0.112	0.138	NS
STAD	Stomach adenocarcinoma	406	-0.132	0.00797	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.344	2.89e-16	Higher

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TBL1XR1.

Summary
Symbol	TBL1XR1
Name	transducin beta like 1 X-linked receptor 1
Aliases	IRA1; FLJ12894; TBLR1; C21; DC42; transducin (beta)-like 1X-linked receptor 1; TBL1-related protein 1; nucle ......
Location	3q26.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27694893	Gastric Carcinoma	upstream	β-catenin; MMP7; EGFR	positive regulation	Moreover, TBL1XR1 mediated ERK1/2 activation is dependent on the β-catenin/MMP7/EGFR signalling pathway.
25341494	Breast Carcinoma	partner	pRb; β-catenin	Positive correlation	We found that TBLR1 expression was implicated in the upregulation of cyclin D1, phosphorylation of cell-cycle control protein Rb (pRb) and activation of β-catenin signaling in breast cancer.
22496164	Lymphoma	partner	TP63	Fusion	Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases.