CR2Cancer

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF03167 Uracil DNA glycosylase superfamily

Function

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

Classification

Class	Modification	Substrate	Product	PubMed
DNA modification	DNA hydroxymethylation	G:U, G:T, G:hmU	C, 5mC, 5hmC	22962365

> Gene Ontology [ TOP ]
Biological Process	GO:0006220 pyrimidine nucleotide metabolic process GO:0006244 pyrimidine nucleotide catabolic process GO:0006284 base-excision repair GO:0006285 base-excision repair, AP site formation GO:0006298 mismatch repair GO:0006304 DNA modification GO:0009166 nucleotide catabolic process GO:0009219 pyrimidine deoxyribonucleotide metabolic process GO:0009223 pyrimidine deoxyribonucleotide catabolic process GO:0009262 deoxyribonucleotide metabolic process GO:0009264 deoxyribonucleotide catabolic process GO:0009394 2'-deoxyribonucleotide metabolic process GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019439 aromatic compound catabolic process GO:0019692 deoxyribose phosphate metabolic process GO:0032091 negative regulation of protein binding GO:0034655 nucleobase-containing compound catabolic process GO:0035510 DNA dealkylation GO:0035511 oxidative DNA demethylation GO:0035561 regulation of chromatin binding GO:0035562 negative regulation of chromatin binding GO:0040029 regulation of gene expression, epigenetic GO:0043393 regulation of protein binding GO:0044270 cellular nitrogen compound catabolic process GO:0044728 DNA methylation or demethylation GO:0045008 depyrimidination GO:0046386 deoxyribose phosphate catabolic process GO:0046434 organophosphate catabolic process GO:0046700 heterocycle catabolic process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0070988 demethylation GO:0070989 oxidative demethylation GO:0072527 pyrimidine-containing compound metabolic process GO:0072529 pyrimidine-containing compound catabolic process GO:0080111 DNA demethylation GO:1901136 carbohydrate derivative catabolic process GO:1901292 nucleoside phosphate catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process
Molecular Function	GO:0000700 mismatch base pair DNA N-glycosylase activity GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0003684 damaged DNA binding GO:0004844 uracil DNA N-glycosylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0019104 DNA N-glycosylase activity GO:0030983 mismatched DNA binding GO:0032182 ubiquitin-like protein binding GO:0032183 SUMO binding GO:0043566 structure-specific DNA binding GO:0097506 deaminated base DNA N-glycosylase activity
Cellular Component	GO:0016604 nuclear body GO:0016605 PML body

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03410 Base excision repair
Reactome	R-HSA-73884: Base Excision Repair R-HSA-73929: Base-Excision Repair, AP Site Formation R-HSA-110329: Cleavage of the damaged pyrimidine R-HSA-73894: DNA Repair R-HSA-73928: Depyrimidination R-HSA-110357: Displacement of DNA glycosylase by APEX1 R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-110328: Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-5221030: TET1,2,3 and TDG demethylate DNA

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03410 Base excision repair

Reactome

R-HSA-73884: Base Excision Repair
R-HSA-73929: Base-Excision Repair, AP Site Formation
R-HSA-110329: Cleavage of the damaged pyrimidine
R-HSA-73894: DNA Repair
R-HSA-73928: Depyrimidination
R-HSA-110357: Displacement of DNA glycosylase by APEX1
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-110328: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-5221030: TET1,2,3 and TDG demethylate DNA

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM2064430	c.1091-1G>A	p.?	Unknown	Lung
COSM3687907	c.253T>C	p.S85P	Substitution - Missense	Large_intestine
COSM5067297	c.613_615-3del201	p.?	Unknown	Large_intestine
COSM3455337	c.625C>T	p.R209C	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5425997	c.930G>A	p.E310E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Liver
COSM285637	c.651G>T	p.Q217H	Substitution - Missense	Large_intestine
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Ovary
COSM691522	c.479-1G>T	p.?	Unknown	Large_intestine
COSM5016889	c.547G>A	p.G183R	Substitution - Missense	Kidney
COSM2064410	c.235C>A	p.P79T	Substitution - Missense	Bone
COSM691520	c.921C>T	p.D307D	Substitution - coding silent	Lung
COSM4596340	c.306T>A	p.F102L	Substitution - Missense	Upper_aerodigestive_tract
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Stomach
COSM4732881	c.844G>A	p.A282T	Substitution - Missense	Large_intestine
COSM1237697	c.287_288insA	p.I98fs*6	Insertion - Frameshift	Soft_tissue
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM934204	c.501G>A	p.G167G	Substitution - coding silent	Endometrium
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM5066858	c.408+1_409-1del820	p.?	Unknown	Large_intestine
COSM5067297	c.613_615-3del201	p.?	Unknown	Large_intestine
COSM5729906	c.751G>T	p.E251*	Substitution - Nonsense	Skin
COSM3398267	c.819T>A	p.S273R	Substitution - Missense	Central_nervous_system
COSM4422030	c.1175T>G	p.I392S	Substitution - Missense	Pleura
COSM691521	c.680C>A	p.A227E	Substitution - Missense	Lung
COSM5174718	c.637C>T	p.R213C	Substitution - Missense	Large_intestine
COSM4435714	c.252A>G	p.K84K	Substitution - coding silent	Oesophagus
COSM1739940	c.537C>T	p.H179H	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM340363	c.516G>T	p.Q172H	Substitution - Missense	Lung
COSM147594	c.167-9G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM95316	c.56C>T	p.T19M	Substitution - Missense	Lung
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM147594	c.167-9G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1240389	c.20G>A	p.G7D	Substitution - Missense	Oesophagus
COSM3792120	c.774G>C	p.K258N	Substitution - Missense	Urinary_tract
COSM4168979	c.946G>C	p.D316H	Substitution - Missense	Peritoneum
COSM934209	c.1224C>T	p.S408S	Substitution - coding silent	Endometrium
COSM934208	c.1123T>G	p.F375V	Substitution - Missense	Endometrium
COSM2064421	c.638G>A	p.R213H	Substitution - Missense	Large_intestine
COSM4448593	c.1090+1G>T	p.?	Unknown	Skin
COSM3383985	c.698-1G>C	p.?	Unknown	Pancreas
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Upper_aerodigestive_tract
COSM3455337	c.625C>T	p.R209C	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM3455336	c.514C>T	p.Q172*	Substitution - Nonsense	Skin
COSM147594	c.167-9G>A	p.?	Unknown	Stomach
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM2064424	c.708A>C	p.E236D	Substitution - Missense	Large_intestine
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM2064410	c.235C>A	p.P79T	Substitution - Missense	Upper_aerodigestive_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Skin
COSM3455334	c.280A>T	p.K94*	Substitution - Nonsense	Skin
COSM3700184	c.460G>T	p.G154*	Substitution - Nonsense	Liver
COSM5729906	c.751G>T	p.E251*	Substitution - Nonsense	Skin
COSM3455333	c.193C>T	p.P65S	Substitution - Missense	Skin
COSM5067297	c.613_615-3del201	p.?	Unknown	Large_intestine
COSM1706179	c.229A>G	p.K77E	Substitution - Missense	Skin
COSM3986579	c.1160C>T	p.S387L	Substitution - Missense	Kidney
COSM2064411	c.246delA	p.K84fs*21	Deletion - Frameshift	Large_intestine
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM934205	c.548G>A	p.G183E	Substitution - Missense	Endometrium
COSM277631	c.1114G>A	p.E372K	Substitution - Missense	Large_intestine
COSM5361588	c.1070G>A	p.G357D	Substitution - Missense	Large_intestine
COSM5067297	c.613_615-3del201	p.?	Unknown	Large_intestine
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Kidney
COSM5067297	c.613_615-3del201	p.?	Unknown	Large_intestine
COSM95735	c.479-1G>C	p.?	Unknown	Lung
COSM2064411	c.246delA	p.K84fs*21	Deletion - Frameshift	Soft_tissue
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5631744	c.1125C>T	p.F375F	Substitution - coding silent	Oesophagus
COSM4746406	c.1091T>97	p.L363_I364ins32	Insertion - In frame	Central_nervous_system
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Breast
COSM3455338	c.911G>A	p.R304Q	Substitution - Missense	Skin
COSM1578447	c.994_995insA	p.Y334fs*2	Insertion - Frameshift	Lung
COSM4994826	c.979_980ins111	p.K326_M327ins37	Insertion - In frame	Large_intestine
COSM5425997	c.930G>A	p.E310E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4890028	c.931G>T	p.V311L	Substitution - Missense	Upper_aerodigestive_tract
COSM5970467	c.673C>T	p.R225*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM691522	c.479-1G>T	p.?	Unknown	Large_intestine
COSM1228814	c.1097G>A	p.S366N	Substitution - Missense	Large_intestine
COSM691519	c.1016A>G	p.E339G	Substitution - Missense	Lung
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Thyroid
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM691523	c.479-1G>A	p.?	Unknown	Lung
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Central_nervous_system
COSM5773064	c.971C>G	p.A324G	Substitution - Missense	Breast
COSM3455337	c.625C>T	p.R209C	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Liver
COSM4789955	c.69A>T	p.Q23H	Substitution - Missense	Liver
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM5361588	c.1070G>A	p.G357D	Substitution - Missense	Large_intestine
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Central_nervous_system
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1578514	c.793-1_793ins11	p.L265fs*30	Unknown	Meninges
COSM1237697	c.287_288insA	p.I98fs*6	Insertion - Frameshift	Thyroid
COSM1358312	c.245_246insA	p.S85fs*19	Insertion - Frameshift	Large_intestine
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5469872	c.423G>A	p.P141P	Substitution - coding silent	Large_intestine
COSM934206	c.686T>C	p.F229S	Substitution - Missense	Endometrium
COSM76698	c.604G>T	p.D202Y	Substitution - Missense	Ovary
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM5445789	c.292_293insA	p.I98fs*6	Insertion - Frameshift	Thyroid
COSM95317	c.1060G>C	p.E354Q	Substitution - Missense	Lung
COSM5174717	c.553T>A	p.Y185N	Substitution - Missense	Large_intestine
COSM1358312	c.245_246insA	p.S85fs*19	Insertion - Frameshift	Large_intestine
COSM2064418	c.591G>A	p.T197T	Substitution - coding silent	Stomach
COSM3455332	c.138C>T	p.A46A	Substitution - coding silent	Skin
COSM5586770	c.1027G>A	p.G343S	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM5012609	c.1181C>A	p.S394Y	Substitution - Missense	Kidney
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3455338	c.911G>A	p.R304Q	Substitution - Missense	Skin
COSM3687908	c.268A>G	p.K90E	Substitution - Missense	Large_intestine
COSM4883259	c.177A>G	p.K59K	Substitution - coding silent	Upper_aerodigestive_tract
COSM4746405	c.1091T>89	p.I364fs*5	Unknown	Central_nervous_system
COSM3967936	c.478+1G>T	p.?	Unknown	Central_nervous_system
COSM4732880	c.195C>G	p.P65P	Substitution - coding silent	Large_intestine
COSM4038165	c.329G>A	p.R110H	Substitution - Missense	Stomach
COSM3398266	c.754T>A	p.F252I	Substitution - Missense	Central_nervous_system
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Kidney
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM3455335	c.294T>C	p.I98I	Substitution - coding silent	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM2064410	c.235C>A	p.P79T	Substitution - Missense	Thyroid
COSM96228	c.879G>A	p.K293K	Substitution - coding silent	Ovary
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM2064410	c.235C>A	p.P79T	Substitution - Missense	Kidney
COSM1605476	c.1001A>G	p.Y334C	Substitution - Missense	Liver
COSM1237697	c.287_288insA	p.I98fs*6	Insertion - Frameshift	Biliary_tract
COSM5568232	c.1159T>C	p.S387P	Substitution - Missense	Prostate
COSM2064408	c.30C>T	p.S10S	Substitution - coding silent	Skin
COSM3746263	c.793-1G>T	p.?	Unknown	Liver
COSM3967937	c.590C>T	p.T197M	Substitution - Missense	Central_nervous_system
COSM4732879	c.184A>G	p.K62E	Substitution - Missense	Large_intestine
COSM3998641	c.1099G>A	p.V367M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2064411	c.246delA	p.K84fs*21	Deletion - Frameshift	Large_intestine
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Thyroid
COSM337316	c.208C>A	p.P70T	Substitution - Missense	Lung
COSM934207	c.1098C>T	p.S366S	Substitution - coding silent	Endometrium
COSM4433393	c.698-1G>T	p.?	Unknown	Oesophagus
COSM1742376	c.859C>T	p.H287Y	Substitution - Missense	Urinary_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Prostate
COSM3998641	c.1099G>A	p.V367M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5066858	c.408+1_409-1del820	p.?	Unknown	Large_intestine
COSM4789955	c.69A>T	p.Q23H	Substitution - Missense	Liver
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Upper_aerodigestive_tract
COSM1605476	c.1001A>G	p.Y334C	Substitution - Missense	Liver
COSM1237697	c.287_288insA	p.I98fs*6	Insertion - Frameshift	Thyroid
COSM5438389	c.116A>T	p.Q39L	Substitution - Missense	Oesophagus
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Stomach
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM1358312	c.245_246insA	p.S85fs*19	Insertion - Frameshift	Large_intestine
COSM4501602	c.593C>A	p.P198H	Substitution - Missense	Skin
COSM3687908	c.268A>G	p.K90E	Substitution - Missense	Breast
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5649856	c.370C>G	p.L124V	Substitution - Missense	Oesophagus
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM5920559	c.1039G>A	p.G347R	Substitution - Missense	Skin
COSM1237697	c.287_288insA	p.I98fs*6	Insertion - Frameshift	Thyroid
COSM221796	c.602A>C	p.K201T	Substitution - Missense	Skin
COSM3810829	c.1009G>A	p.G337S	Substitution - Missense	Breast
COSM147595	c.510G>A	p.E170E	Substitution - coding silent	Thyroid
COSM3967935	c.421C>T	p.P141S	Substitution - Missense	Central_nervous_system
COSM3998641	c.1099G>A	p.V367M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3455337	c.625C>T	p.R209C	Substitution - Missense	Skin
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Central_nervous_system
COSM3455337	c.625C>T	p.R209C	Substitution - Missense	Skin
COSM76699	c.983C>T	p.A328V	Substitution - Missense	Ovary
COSM112087	c.286_287insA	p.I98fs*6	Insertion - Frameshift	Skin
COSM122020	c.387C>A	p.T129T	Substitution - coding silent	Stomach

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
22608206	loss of expression (mutation)	Rectal Carcinoma	Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency. We identified a heterozygous missense mutation in TDG, which was associated with TDG protein loss in the tumor.

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.262	4.905	0.573	0.00043	NS
BRCA	Breast invasive carcinoma	112	1100	4.261	4.654	0.46	1.06e-16	NS
CESC	Cervical and endocervical cancers	3	306	3.664	4.95	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.439	4.806	0.322	0.000443	NS
ESCA	Esophageal carcinoma	11	185	4.375	5.25	0.647	0.00166	Over
GBM	Glioblastoma multiforme	5	166	3.596	4.22	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.559	4.828	0.389	1.15e-05	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.836	4.274	0.415	2.71e-17	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.569	4.092	0.539	1.61e-09	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.43	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.552	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.08	3.225	0.172	0.0569	NS
LUAD	Lung adenocarcinoma	59	517	4.013	4.533	0.558	9.86e-10	NS
LUSC	Lung squamous cell carcinoma	51	501	4.099	5.277	1.205	1.8e-45	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.605	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.209	4.117	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.383	3.765	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.88	4.122	0.226	0.00135	NS
READ	Rectum adenocarcinoma	10	167	4.799	4.686	-0.002	0.993	NS
SARC	Sarcoma	2	263	3.23	3.717	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.293	3.989	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.09	4.741	0.669	8.02e-10	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.609	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.05	3.84	-0.15	0.00262	NS
THYM	Thymoma	2	120	4.849	4.504	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.055	5.155	1.005	3.71e-20	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	11.7
Adrenal gland	14.4
Appendix	20.8
Bone marrow	10.8
Breast	14.6
Cerebral cortex	10.6
Cervix, uterine	15.1
Colon	12.5
Duodenum	10.7
Endometrium	19.2
Epididymis	11.6
Esophagus	16
Fallopian tube	11.9
Gallbladder	18.6
Heart muscle	5.7
Kidney	8
Liver	5.4
Lung	14
Lymph node	23.5
Ovary	11.1
Pancreas	1.6
Parathyroid gland	15.4
Placenta	23.6
Prostate	14.4
Rectum	17
Salivary gland	3
Seminal vesicle	9.9
Skeletal muscle	3
Skin	13.6
Small intestine	13.8
Smooth muscle	15.3
Spleen	15.9
Stomach	10.1
Testis	8.8
Thyroid gland	16.7
Tonsil	17.3
Urinary bladder	15.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
25098926	Underexpression	Gastric Carcinoma	The loss of 5-hmC and the down-regulation of TET1-3, TDG and IDH2 were found in GCs.
26207381	Underexpression	Early-Stage Breast Carcinoma	Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.
24748645	Overexpression	Colon Carcinoma	Moreover, there is an elevation of TDG levels in human colon cancer tissue, and knockdown of TDG inhibits proliferation of the colon cells.
24532795	Overexpression	Colorectal Carcinoma	Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
24096364	Overexpression	All Cancers except Kidney Carcinoma	We observed a very strong inverse correlation between miR-29a and TDG across all cancer types except kidney cancer, and TET1 expression was strongly negatively correlated with miR-29 family members in all cancer types. miR-29a was generally downregulated, andTET1andTDGwere generally upregulated, in tumors of most cancer types as compared with representative normal samples
22875744	altered expression	Breast Carcinoma	These included five genes (BRCA1, MRE11A, NBS1, TDG, and XPA) whose transcript levels were associated with resistance and two genes (CHEK2 and MK2) whose transcript levels were associated with sensitivity.
22608206	loss of expression (mutation)	Rectal Carcinoma	Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency. We identified a heterozygous missense mutation in TDG, which was associated with TDG protein loss in the tumor.
10360221	Underexpression	Pancreatic Ductal Adenocarcinoma	Abnormality of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 appears to play a limited role in pancreatic ductal carcinogenesis. Decreased levels of mRNA expression were detected in the pancreatic cancer cell lines, but no somatic mutations were observed.
26370152	SNP; altered expression	Skin Carcinoma	The nonsynonymous coding SNP (rs2888805) and the intronic SNP (rs4135150) of TDG are associated with increased risk of developing nonmelanoma skin cancer and other cancers. In addition to gastrointestinal cancers, the mRNA levels ofTDGincrease in p53-mutated adrenocortical tumors associated with Li-Faumeni syndrome, but in multiple myeloma cell lines and pancreatic adenocarcinoma , theTDGmRNA levels decrease.

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.531	9.95e-31	17.6	59.7	22.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.427	5.84e-49	18.8	64.4	16.8	Neutral
CESC	Cervical and endocervical cancers	292	0.351	6.52e-10	7.2	76.7	16.1	Neutral
COAD	Colon adenocarcinoma	449	0.425	3.78e-21	13.1	66.8	20	Neutral
ESCA	Esophageal carcinoma	183	0.547	1.15e-15	25.1	54.6	20.2	Neutral
GBM	Glioblastoma multiforme	147	0.304	0.000183	8.2	82.3	9.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.256	3.84e-09	10.5	74.9	14.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.341	9.06e-16	1.1	75.8	23	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.515	6.63e-21	0	60.1	39.9	Gain
LAML	Acute Myeloid Leukemia	166	0.129	0.0986	0.6	99.4	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.292	1.59e-11	11.5	86.2	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.435	3.07e-18	12.1	74.2	13.7	Neutral
LUAD	Lung adenocarcinoma	512	0.6	2.68e-51	24	52.5	23.4	Neutral
LUSC	Lung squamous cell carcinoma	498	0.419	1.43e-22	15.5	59	25.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.689	1.76e-43	31.3	41.3	27.3	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.53	3.17e-14	22.6	67.2	10.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.259	0.000865	2.5	89.5	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.305	4.64e-12	4.5	88.6	6.9	Neutral
READ	Rectum adenocarcinoma	164	0.499	9.88e-12	15.2	71.3	13.4	Neutral
SARC	Sarcoma	255	0.502	1.07e-17	24.3	55.3	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.363	7.15e-13	24.8	67.3	7.9	Neutral
STAD	Stomach adenocarcinoma	413	0.365	1.75e-14	13.6	66.6	19.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.283	0.00045	2	41.3	56.7	Gain
THCA	Thyroid carcinoma	497	0.256	7.09e-09	0	97	3	Neutral
THYM	Thymoma	119	0.295	0.00115	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.351	4.89e-17	9.9	80.1	10.1	Neutral

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.17	0.00045	17	408	-0.052	0.00882	NS/NA
BRCA	Breast invasive carcinoma	-0.207	8.23e-10	83	785	-0.032	0.000148	NS/NA
CESC	Cervical and endocervical cancers	-0.129	0.0232	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.124	0.0282	19	297	-0.002	0.985	NS/NA
ESCA	Esophageal carcinoma	-0.256	0.000325	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.126	0.318	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.06	0.16	20	522	0.001	0.00263	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.195	0.000298	24	319	0.003	4.68e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.188	0.0011	23	275	-0.015	0.00405	NS/NA
LAML	Acute Myeloid Leukemia	-0.138	0.0732	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.044	0.312	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.14	0.00435	41	373	-0.007	0.136	NS/NA
LUAD	Lung adenocarcinoma	-0.093	0.0414	21	456	-0.03	0.599	NS/NA
LUSC	Lung squamous cell carcinoma	-0.211	3.77e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.75	0.0255	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.276	0.000162	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.098	0.18	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.074	0.0876	35	498	0.002	0.00307	NS/NA
READ	Rectum adenocarcinoma	-0.144	0.151	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.192	0.00175	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.155	0.000728	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.201	0.000101	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.258	0.00117	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.025	0.559	50	509	-0.001	0.255	NS/NA
THYM	Thymoma	-0.235	0.00939	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.174	0.00017	34	431	0	0.902	NS/NA

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	2	Medium
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	1	Low
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0968	NS	24476821
BRCA	Breast invasive carcinoma	521	1.73e-16	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000914	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0605	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	9.39e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0368	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.81	NS	26824661
LUAD	Lung adenocarcinoma	230	1.19e-14	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	4.1e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000248	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.11e-09	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0371	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.115	NS	26091043
STAD	Stomach adenocarcinoma	277	3.55e-10	Significant	25079317
THCA	Thyroid carcinoma	391	0.542	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.305	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.89	0.583	NS
BRCA	Breast invasive carcinoma	1079	1.233	0.383	NS
CESC	Cervical and endocervical cancers	291	1.587	0.16	NS
COAD	Colon adenocarcinoma	439	0.448	0.0184	Longer
ESCA	Esophageal carcinoma	184	2.336	0.0174	Shorter
GBM	Glioblastoma multiforme	158	0.783	0.34	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.259	0.246	NS
KIRC	Kidney renal clear cell carcinoma	531	3.161	2.26e-07	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	3.36	0.0048	Shorter
LAML	Acute Myeloid Leukemia	149	0.845	0.557	NS
LGG	Brain Lower Grade Glioma	511	1.401	0.169	NS
LIHC	Liver hepatocellular carcinoma	365	1.77	0.0162	Shorter
LUAD	Lung adenocarcinoma	502	1.955	0.00145	Shorter
LUSC	Lung squamous cell carcinoma	494	0.709	0.0899	NS
OV	Ovarian serous cystadenocarcinoma	303	1.188	0.414	NS
PAAD	Pancreatic adenocarcinoma	177	1.149	0.639	NS
PCPG	Pheochromocytoma and Paraganglioma	179	774289371.398	0.564	NS
PRAD	Prostate adenocarcinoma	497	511523436.228	0.0664	NS
READ	Rectum adenocarcinoma	159	0.919	0.871	NS
SARC	Sarcoma	259	2.339	0.00511	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.157	0.456	NS
STAD	Stomach adenocarcinoma	388	1.107	0.641	NS
TGCT	Testicular Germ Cell Tumors	134	0.965	0.98	NS
THCA	Thyroid carcinoma	500	1.102	0.862	NS
THYM	Thymoma	119	0.199	0.122	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.508	0.0265	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.142	0.00408	Lower
BRCA	Breast invasive carcinoma	1071	0.025	0.421	NS
CESC	Cervical and endocervical cancers	167	-0.019	0.811	NS
COAD	Colon adenocarcinoma	445	-0.116	0.0146	Lower
ESCA	Esophageal carcinoma	162	0.039	0.625	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.045	0.338	NS
KIRC	Kidney renal clear cell carcinoma	531	0.257	1.92e-09	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.14	0.0244	Higher
LIHC	Liver hepatocellular carcinoma	347	0.113	0.0353	Higher
LUAD	Lung adenocarcinoma	507	0.099	0.0264	Higher
LUSC	Lung squamous cell carcinoma	497	0.022	0.622	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.131	0.0226	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.057	0.449	NS
READ	Rectum adenocarcinoma	156	-0.108	0.178	NS
SKCM	Skin Cutaneous Melanoma	410	-0.002	0.968	NS
STAD	Stomach adenocarcinoma	392	0.035	0.492	NS
TGCT	Testicular Germ Cell Tumors	81	0.384	0.000398	Higher
THCA	Thyroid carcinoma	499	-0.135	0.00244	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.035	0.437	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.044	0.467	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.233	1.46e-07	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.164	0.000154	Higher
LGG	Brain Lower Grade Glioma	514	0.171	9.39e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	0.272	1.19e-07	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.075	0.198	NS
PAAD	Pancreatic adenocarcinoma	176	-0.051	0.504	NS
STAD	Stomach adenocarcinoma	406	-0.175	0.000394	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.019	0.66	NS

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TDG.

Summary
Symbol	TDG
Name	thymine DNA glycosylase
Aliases	G/T mismatch-specific thymine DNA glycosylase; hTDG; thymine-DNA glycosylase
Location	12q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24748645	Colon Carcinoma	downstream	β-catenin/TCFs	Positive regulation	Our data show that TDG binds to the transcriptional factor family LEF1/TCFs and potentiates β-catenin/TCFs transactivation, while TDG depletion suppresses Wnt3a-stimulated reporter activity or target gene transcription.
24532795	Colorectal Carcinoma	downstream	Wnt signaling	Positive regulation	While screening a panel of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling.
24096364	All Cancers except Kidney Carcinoma	partner	miR-29a	Negative correlation	We observed a very strong inverse correlation between miR-29a andTDGacross all cancer types except kidney cancer, andTET1expression was strongly negatively correlated with miR-29 family members in all cancer types.