CR2Cancer

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00567 Tudor domain
PF01753 MYND finger

Function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0016458 gene silencing GO:0022412 cellular process involved in reproduction in multicellular organism GO:0031047 gene silencing by RNA GO:0032259 methylation GO:0034587 piRNA metabolic process GO:0043046 DNA methylation involved in gamete generation GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0048232 male gamete generation GO:0051321 meiotic cell cycle
Molecular Function	-
Cellular Component	GO:0033391 chromatoid body GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule GO:0043186 P granule GO:0045495 pole plasm GO:0060293 germ plasm GO:0071546 pi-body

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-211000: Gene Silencing by RNA R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM915016	c.1432G>A	p.V478I	Substitution - Missense	Endometrium
COSM1321524	c.2770+1G>T	p.?	Unknown	Ovary
COSM1675577	c.2499A>G	p.I833M	Substitution - Missense	Large_intestine
COSM1638441	c.2313delT	p.F773fs*11	Deletion - Frameshift	Stomach
COSM465289	c.2574A>G	p.Q858Q	Substitution - coding silent	Kidney
COSM233559	c.2093G>A	p.G698E	Substitution - Missense	Skin
COSM4573348	c.2970A>T	p.R990S	Substitution - Missense	Bone
COSM5510466	c.279C>T	p.N93N	Substitution - coding silent	Biliary_tract
COSM1602995	c.1469T>A	p.L490*	Substitution - Nonsense	Liver
COSM1675576	c.2258G>A	p.C753Y	Substitution - Missense	Large_intestine
COSM4732888	c.15G>A	p.S5S	Substitution - coding silent	Large_intestine
COSM285639	c.3327C>T	p.V1109V	Substitution - coding silent	Large_intestine
COSM1726953	c.2552G>T	p.C851F	Substitution - Missense	Liver
COSM4818368	c.2212+2T>C	p.?	Unknown	Cervix
COSM129640	c.3425G>A	p.C1142Y	Substitution - Missense	Upper_aerodigestive_tract
COSM4500222	c.55C>T	p.P19S	Substitution - Missense	Skin
COSM1492209	c.2147T>C	p.V716A	Substitution - Missense	Kidney
COSM1180185	c.94G>A	p.E32K	Substitution - Missense	Prostate
COSM915027	c.2803G>T	p.E935*	Substitution - Nonsense	Endometrium
COSM4551521	c.530G>A	p.G177E	Substitution - Missense	Skin
COSM1128133	c.3306A>C	p.K1102N	Substitution - Missense	Prostate
COSM1602996	c.1611C>T	p.R537R	Substitution - coding silent	Liver
COSM1703075	c.2882G>A	p.G961E	Substitution - Missense	Skin
COSM5370101	c.165G>A	p.L55L	Substitution - coding silent	Skin
COSM3434300	c.2799G>A	p.T933T	Substitution - coding silent	Skin
COSM254974	c.2792G>A	p.W931*	Substitution - Nonsense	Urinary_tract
COSM3434291	c.1055G>A	p.G352E	Substitution - Missense	Skin
COSM4626623	c.1228A>G	p.I410V	Substitution - Missense	Large_intestine
COSM1637787	c.2444C>A	p.S815*	Substitution - Nonsense	Bone
COSM5417872	c.3089T>C	p.I1030T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM915009	c.612C>T	p.I204I	Substitution - coding silent	Endometrium
COSM5909054	c.1831+5G>A	p.?	Unknown	Skin
COSM4536636	c.2324G>T	p.G775V	Substitution - Missense	Skin
COSM3434294	c.1454C>T	p.P485L	Substitution - Missense	Skin
COSM415163	c.3091G>A	p.E1031K	Substitution - Missense	Urinary_tract
COSM254975	c.2866T>C	p.Y956H	Substitution - Missense	Urinary_tract
COSM6014101	c.496C>T	p.R166W	Substitution - Missense	Skin
COSM1703071	c.1969G>A	p.E657K	Substitution - Missense	Skin
COSM5820873	c.1657T>A	p.S553T	Substitution - Missense	Liver
COSM4570483	c.2779T>C	p.S927P	Substitution - Missense	Skin
COSM915023	c.2058C>T	p.D686D	Substitution - coding silent	Endometrium
COSM1686642	c.697-1G>A	p.?	Unknown	Skin
COSM1321525	c.2575G>C	p.A859P	Substitution - Missense	Ovary
COSM4651751	c.3361G>A	p.A1121T	Substitution - Missense	Large_intestine
COSM5966905	c.3016T>A	p.F1006I	Substitution - Missense	Adrenal_gland
COSM5819589	c.1916A>T	p.K639I	Substitution - Missense	Liver
COSM3978100	c.1977T>C	p.P659P	Substitution - coding silent	Lung
COSM4011745	c.507T>G	p.T169T	Substitution - coding silent	Stomach
COSM3806484	c.2196T>C	p.H732H	Substitution - coding silent	Breast
COSM4732891	c.1534delC	p.Q512fs*66	Deletion - Frameshift	Large_intestine
COSM915017	c.1656C>T	p.F552F	Substitution - coding silent	Endometrium
COSM3434296	c.1752C>T	p.I584I	Substitution - coding silent	Skin
COSM5999172	c.2106A>G	p.P702P	Substitution - coding silent	Prostate
COSM915024	c.2220G>T	p.K740N	Substitution - Missense	Large_intestine
COSM4856663	c.46G>A	p.E16K	Substitution - Missense	Cervix
COSM4945538	c.2651T>A	p.I884N	Substitution - Missense	Liver
COSM1675577	c.2499A>G	p.I833M	Substitution - Missense	Large_intestine
COSM4011747	c.1329G>A	p.M443I	Substitution - Missense	Stomach
COSM915024	c.2220G>T	p.K740N	Substitution - Missense	Endometrium
COSM915028	c.3315G>T	p.E1105D	Substitution - Missense	Endometrium
COSM5589133	c.2278G>A	p.G760S	Substitution - Missense	Skin
COSM1703079	c.3522G>A	p.M1174I	Substitution - Missense	Skin
COSM3806485	c.2342G>A	p.R781H	Substitution - Missense	Biliary_tract
COSM4414091	c.1165G>A	p.G389R	Substitution - Missense	Kidney
COSM3434299	c.2622C>T	p.T874T	Substitution - coding silent	Skin
COSM415164	c.276C>T	p.I92I	Substitution - coding silent	Urinary_tract
COSM235474	c.840C>T	p.Y280Y	Substitution - coding silent	Endometrium
COSM5739042	c.411_412insA	p.S139fs*16	Insertion - Frameshift	Small_intestine
COSM683252	c.601G>T	p.A201S	Substitution - Missense	Lung
COSM3866545	c.192G>A	p.K64K	Substitution - coding silent	Skin
COSM1703073	c.2105C>T	p.P702L	Substitution - Missense	Skin
COSM3414703	c.2752C>A	p.H918N	Substitution - Missense	Large_intestine
COSM4940458	c.3541A>G	p.T1181A	Substitution - Missense	Liver
COSM254975	c.2866T>C	p.Y956H	Substitution - Missense	Urinary_tract
COSM211974	c.3305A>C	p.K1102T	Substitution - Missense	Breast
COSM4802025	c.1603C>A	p.P535T	Substitution - Missense	Liver
COSM1188058	c.1948G>T	p.V650L	Substitution - Missense	Lung
COSM1703072	c.2077C>A	p.P693T	Substitution - Missense	Skin
COSM5477104	c.529+10T>G	p.?	Unknown	Large_intestine
COSM4011750	c.2750T>C	p.V917A	Substitution - Missense	Stomach
COSM5370100	c.144T>G	p.P48P	Substitution - coding silent	Skin
COSM143503	c.55_56CC>TT	p.P19F	Substitution - Missense	Skin
COSM254974	c.2792G>A	p.W931*	Substitution - Nonsense	Urinary_tract
COSM4570943	c.3515T>A	p.I1172N	Substitution - Missense	Skin
COSM3866549	c.3183G>A	p.M1061I	Substitution - Missense	Skin
COSM1703078	c.3481C>T	p.L1161F	Substitution - Missense	Skin
COSM1675574	c.1063G>T	p.E355*	Substitution - Nonsense	Large_intestine
COSM5359955	c.2957G>A	p.R986Q	Substitution - Missense	Large_intestine
COSM3414702	c.1529T>G	p.F510C	Substitution - Missense	Large_intestine
COSM1675578	c.2803G>A	p.E935K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1703069	c.1739G>A	p.G580E	Substitution - Missense	Skin
COSM1675575	c.1620T>G	p.F540L	Substitution - Missense	Large_intestine
COSM5359955	c.2957G>A	p.R986Q	Substitution - Missense	Large_intestine
COSM3434302	c.3145C>T	p.P1049S	Substitution - Missense	Skin
COSM1703067	c.1073C>T	p.P358L	Substitution - Missense	Skin
COSM3806485	c.2342G>A	p.R781H	Substitution - Missense	Breast
COSM252866	c.2434C>T	p.R812*	Substitution - Nonsense	Ovary
COSM1720665	c.266C>T	p.P89L	Substitution - Missense	Skin
COSM4165382	c.1099A>T	p.R367W	Substitution - Missense	Kidney
COSM1703076	c.3103C>T	p.L1035F	Substitution - Missense	Skin
COSM915015	c.1318C>T	p.L440F	Substitution - Missense	Endometrium
COSM2053985	c.3328G>A	p.D1110N	Substitution - Missense	Skin
COSM277634	c.2182G>A	p.E728K	Substitution - Missense	Large_intestine
COSM3367900	c.2385A>G	p.V795V	Substitution - coding silent	Thyroid
COSM4011749	c.1892T>C	p.V631A	Substitution - Missense	Stomach
COSM3414704	c.3140C>T	p.A1047V	Substitution - Missense	Large_intestine
COSM3665504	c.3249T>C	p.N1083N	Substitution - coding silent	Liver
COSM254973	c.2005G>C	p.D669H	Substitution - Missense	Urinary_tract
COSM5625058	c.841G>A	p.V281M	Substitution - Missense	Oesophagus
COSM3930914	c.2470C>T	p.Q824*	Substitution - Nonsense	Urinary_tract
COSM226673	c.1381C>T	p.Q461*	Substitution - Nonsense	Skin
COSM3396923	c.135A>G	p.G45G	Substitution - coding silent	Central_nervous_system
COSM5347341	c.203delT	p.L68fs*29	Deletion - Frameshift	Liver
COSM915008	c.389C>T	p.P130L	Substitution - Missense	Endometrium
COSM1703076	c.3103C>T	p.L1035F	Substitution - Missense	Skin
COSM3434298	c.2402G>A	p.G801E	Substitution - Missense	Skin
COSM1602996	c.1611C>T	p.R537R	Substitution - coding silent	Liver
COSM4732893	c.3362_3363insA	p.N1123fs*17	Insertion - Frameshift	Large_intestine
COSM1703074	c.2110G>A	p.E704K	Substitution - Missense	Skin
COSM1675576	c.2258G>A	p.C753Y	Substitution - Missense	Large_intestine
COSM915007	c.326-2A>G	p.?	Unknown	Endometrium
COSM5012239	c.2834A>T	p.N945I	Substitution - Missense	Kidney
COSM1703068	c.1403G>A	p.G468E	Substitution - Missense	Skin
COSM5969653	c.3275C>A	p.T1092K	Substitution - Missense	Upper_aerodigestive_tract
COSM5654867	c.1952A>C	p.E651A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3434290	c.949G>A	p.E317K	Substitution - Missense	Skin
COSM4173910	c.198T>A	p.N66K	Substitution - Missense	Large_intestine
COSM3670450	c.2622C>A	p.T874T	Substitution - coding silent	Prostate
COSM915014	c.1276G>T	p.E426*	Substitution - Nonsense	Endometrium
COSM683254	c.301G>A	p.G101R	Substitution - Missense	Lung
COSM1288403	c.3175G>T	p.G1059*	Substitution - Nonsense	Autonomic_ganglia
COSM252866	c.2434C>T	p.R812*	Substitution - Nonsense	Large_intestine
COSM1470303	c.1726T>C	p.Y576H	Substitution - Missense	Prostate
COSM326648	c.2644A>T	p.R882*	Substitution - Nonsense	Lung
COSM145999	c.195C>A	p.N65K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1492210	c.1832-2A>T	p.?	Unknown	Kidney
COSM4428033	c.304G>C	p.D102H	Substitution - Missense	Oesophagus
COSM915011	c.674A>C	p.K225T	Substitution - Missense	Endometrium
COSM1675576	c.2258G>A	p.C753Y	Substitution - Missense	Large_intestine
COSM915020	c.1968C>A	p.S656S	Substitution - coding silent	Endometrium
COSM5370102	c.433T>C	p.L145L	Substitution - coding silent	Skin
COSM254973	c.2005G>C	p.D669H	Substitution - Missense	Urinary_tract
COSM5370105	c.2481G>A	p.R827R	Substitution - coding silent	Skin
COSM427093	c.1142T>C	p.V381A	Substitution - Missense	Breast
COSM1703073	c.2105C>T	p.P702L	Substitution - Missense	Skin
COSM5818918	c.3042G>A	p.G1014G	Substitution - coding silent	Liver
COSM4539941	c.2762G>A	p.G921E	Substitution - Missense	Skin
COSM5724047	c.3203C>T	p.S1068F	Substitution - Missense	Skin
COSM4606833	c.2138A>T	p.D713V	Substitution - Missense	Adrenal_gland
COSM5724047	c.3203C>T	p.S1068F	Substitution - Missense	Skin
COSM4449805	c.3363delA	p.N1123fs*10	Deletion - Frameshift	Skin
COSM254975	c.2866T>C	p.Y956H	Substitution - Missense	Urinary_tract
COSM3434288	c.792G>A	p.M264I	Substitution - Missense	Skin
COSM915005	c.35G>T	p.R12I	Substitution - Missense	Endometrium
COSM3665503	c.1292A>T	p.N431I	Substitution - Missense	Liver
COSM1703077	c.3452T>C	p.V1151A	Substitution - Missense	Skin
COSM235474	c.840C>T	p.Y280Y	Substitution - coding silent	Skin
COSM233559	c.2093G>A	p.G698E	Substitution - Missense	Skin
COSM3414701	c.1527C>A	p.F509L	Substitution - Missense	Large_intestine
COSM915012	c.806C>T	p.T269M	Substitution - Missense	Endometrium
COSM4612964	c.417delA	p.K141fs*2	Deletion - Frameshift	Large_intestine
COSM1288402	c.3094A>C	p.T1032P	Substitution - Missense	Autonomic_ganglia
COSM3434301	c.3025C>T	p.R1009C	Substitution - Missense	Skin
COSM2053979	c.2986G>A	p.A996T	Substitution - Missense	Large_intestine
COSM4573347	c.2051C>A	p.P684H	Substitution - Missense	Bone
COSM1675575	c.1620T>G	p.F540L	Substitution - Missense	Large_intestine
COSM4011748	c.1551C>A	p.G517G	Substitution - coding silent	Stomach
COSM4447301	c.1126-3C>T	p.?	Unknown	Skin
COSM5785868	c.515G>A	p.R172H	Substitution - Missense	Breast
COSM4834506	c.1978C>G	p.H660D	Substitution - Missense	Cervix
COSM915025	c.2292G>T	p.E764D	Substitution - Missense	Endometrium
COSM3806483	c.1530T>G	p.F510L	Substitution - Missense	Breast
COSM5370103	c.807G>A	p.T269T	Substitution - coding silent	Skin
COSM4382509	c.1009G>A	p.V337I	Substitution - Missense	Large_intestine
COSM683253	c.303A>T	p.G101G	Substitution - coding silent	Lung
COSM3866546	c.1082G>A	p.R361K	Substitution - Missense	Skin
COSM5821249	c.1658C>A	p.S553*	Substitution - Nonsense	Liver
COSM5802816	c.2435G>A	p.R812Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5650812	c.2648T>C	p.I883T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM348184	c.601G>A	p.A201T	Substitution - Missense	Lung
COSM915012	c.806C>T	p.T269M	Substitution - Missense	Stomach
COSM233559	c.2093G>A	p.G698E	Substitution - Missense	Skin
COSM915019	c.1874G>T	p.C625F	Substitution - Missense	Endometrium
COSM915029	c.3348G>A	p.V1116V	Substitution - coding silent	Endometrium
COSM3709756	c.1389T>C	p.D463D	Substitution - coding silent	Upper_aerodigestive_tract
COSM3866548	c.1856G>A	p.W619*	Substitution - Nonsense	Skin
COSM4846219	c.85G>C	p.E29Q	Substitution - Missense	Cervix
COSM5940083	c.2065G>A	p.E689K	Substitution - Missense	Skin
COSM4732890	c.547C>T	p.Q183*	Substitution - Nonsense	Large_intestine
COSM5780685	c.3292G>C	p.V1098L	Substitution - Missense	Breast
COSM5593409	c.2465C>T	p.P822L	Substitution - Missense	Skin
COSM1675574	c.1063G>T	p.E355*	Substitution - Nonsense	Large_intestine
COSM683254	c.301G>A	p.G101R	Substitution - Missense	Skin
COSM3434293	c.1369G>A	p.E457K	Substitution - Missense	Skin
COSM5632495	c.1961A>G	p.D654G	Substitution - Missense	Oesophagus
COSM3434292	c.1164A>G	p.E388E	Substitution - coding silent	Skin
COSM1703071	c.1969G>A	p.E657K	Substitution - Missense	Pituitary
COSM4760418	c.3251T>G	p.V1084G	Substitution - Missense	Stomach
COSM3434303	c.3334G>A	p.A1112T	Substitution - Missense	Skin
COSM4928497	c.3344T>G	p.L1115R	Substitution - Missense	Liver
COSM5913125	c.2981G>A	p.G994E	Substitution - Missense	Skin
COSM683250	c.1644T>C	p.C548C	Substitution - coding silent	Lung
COSM3665504	c.3249T>C	p.N1083N	Substitution - coding silent	Liver
COSM3866544	c.142C>T	p.P48S	Substitution - Missense	Skin
COSM5477105	c.1766G>A	p.R589K	Substitution - Missense	Large_intestine
COSM5724047	c.3203C>T	p.S1068F	Substitution - Missense	Skin
COSM4912005	c.3410T>C	p.M1137T	Substitution - Missense	Liver
COSM1703070	c.1850G>A	p.G617E	Substitution - Missense	Skin
COSM2053943	c.1349G>C	p.S450T	Substitution - Missense	Large_intestine
COSM1675576	c.2258G>A	p.C753Y	Substitution - Missense	Large_intestine
COSM1321526	c.2479C>T	p.R827W	Substitution - Missense	Ovary
COSM4807033	c.3241A>C	p.N1081H	Substitution - Missense	Pancreas
COSM5024627	c.2303C>A	p.P768H	Substitution - Missense	Large_intestine
COSM315854	c.2684T>C	p.L895S	Substitution - Missense	Lung
COSM683251	c.818T>G	p.F273C	Substitution - Missense	Lung
COSM4937740	c.929A>G	p.D310G	Substitution - Missense	Liver
COSM5961434	c.122T>C	p.L41S	Substitution - Missense	Adrenal_gland
COSM4573346	c.1315G>A	p.V439M	Substitution - Missense	Bone
COSM5999173	c.3071A>G	p.Y1024C	Substitution - Missense	Prostate
COSM4935467	c.3137T>C	p.L1046P	Substitution - Missense	Liver
COSM4845420	c.2002C>A	p.L668I	Substitution - Missense	Cervix
COSM1703066	c.175G>A	p.E59K	Substitution - Missense	Skin
COSM4011751	c.2813T>C	p.V938A	Substitution - Missense	Stomach
COSM3985427	c.2382A>T	p.K794N	Substitution - Missense	Kidney
COSM1296949	c.649G>A	p.E217K	Substitution - Missense	Urinary_tract
COSM277635	c.3512T>G	p.F1171C	Substitution - Missense	Large_intestine
COSM1228825	c.2663T>G	p.L888R	Substitution - Missense	Large_intestine
COSM5909054	c.1831+5G>A	p.?	Unknown	Skin
COSM3434304	c.3497C>T	p.T1166I	Substitution - Missense	Skin
COSM4011744	c.488C>T	p.P163L	Substitution - Missense	Stomach
COSM1720665	c.266C>T	p.P89L	Substitution - Missense	Skin
COSM1703069	c.1739G>A	p.G580E	Substitution - Missense	Skin
COSM1321526	c.2479C>T	p.R827W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3978099	c.281G>T	p.G94V	Substitution - Missense	Lung
COSM5012238	c.892A>T	p.S298C	Substitution - Missense	Kidney
COSM5360335	c.814G>A	p.E272K	Substitution - Missense	Large_intestine
COSM5012237	c.485G>C	p.G162A	Substitution - Missense	Kidney
COSM915021	c.1973C>T	p.T658M	Substitution - Missense	Endometrium
COSM1675577	c.2499A>G	p.I833M	Substitution - Missense	Large_intestine
COSM1289316	c.933T>C	p.Y311Y	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5700116	c.1654T>C	p.F552L	Substitution - Missense	Soft_tissue
COSM1703070	c.1850G>A	p.G617E	Substitution - Missense	Skin
COSM145999	c.195C>A	p.N65K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3709756	c.1389T>C	p.D463D	Substitution - coding silent	Upper_aerodigestive_tract
COSM1474366	c.3203C>G	p.S1068C	Substitution - Missense	Breast
COSM683249	c.2120G>T	p.W707L	Substitution - Missense	Lung
COSM4609600	c.2321C>A	p.A774E	Substitution - Missense	Adrenal_gland
COSM277633	c.2065G>T	p.E689*	Substitution - Nonsense	Large_intestine
COSM915006	c.37A>C	p.N13H	Substitution - Missense	Endometrium
COSM427095	c.3264G>C	p.V1088V	Substitution - coding silent	Breast
COSM5924519	c.2371G>A	p.G791R	Substitution - Missense	Skin
COSM348185	c.3010G>A	p.D1004N	Substitution - Missense	Lung
COSM4941909	c.482T>C	p.L161S	Substitution - Missense	Liver
COSM3434295	c.1636G>A	p.D546N	Substitution - Missense	Skin
COSM4570917	c.3482T>A	p.L1161H	Substitution - Missense	Skin
COSM247771	c.3256C>A	p.L1086I	Substitution - Missense	Prostate
COSM427094	c.2777C>G	p.S926C	Substitution - Missense	Breast
COSM254974	c.2792G>A	p.W931*	Substitution - Nonsense	Urinary_tract
COSM1162899	c.416_417insA	p.L142fs*13	Insertion - Frameshift	Pancreas
COSM254973	c.2005G>C	p.D669H	Substitution - Missense	Urinary_tract
COSM5802743	c.6T>A	p.S2R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5802745	c.5G>A	p.S2N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1177130	c.3404-1G>A	p.?	Unknown	Endometrium
COSM5370104	c.2474G>A	p.G825E	Substitution - Missense	Skin
COSM5370106	c.2881_2882GG>AA	p.G961K	Substitution - Missense	Skin
COSM5597709	c.3083G>A	p.G1028E	Substitution - Missense	Skin
COSM4449805	c.3363delA	p.N1123fs*10	Deletion - Frameshift	Large_intestine
COSM915026	c.2693C>T	p.A898V	Substitution - Missense	Endometrium
COSM1289315	c.267G>T	p.P89P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3434293	c.1369G>A	p.E457K	Substitution - Missense	Skin
COSM3866547	c.1282G>A	p.E428K	Substitution - Missense	Skin
COSM1162899	c.416_417insA	p.L142fs*13	Insertion - Frameshift	Large_intestine
COSM915010	c.659C>A	p.S220*	Substitution - Nonsense	Endometrium
COSM4826237	c.3337G>C	p.D1113H	Substitution - Missense	Cervix
COSM915018	c.1818G>A	p.K606K	Substitution - coding silent	Endometrium
COSM4732889	c.438C>T	p.V146V	Substitution - coding silent	Large_intestine
COSM1602995	c.1469T>A	p.L490*	Substitution - Nonsense	Liver
COSM5724047	c.3203C>T	p.S1068F	Substitution - Missense	Skin
COSM915013	c.1082G>T	p.R361I	Substitution - Missense	Endometrium
COSM4830570	c.2137G>A	p.D713N	Substitution - Missense	Cervix
COSM4486813	c.3101C>T	p.P1034L	Substitution - Missense	Skin
COSM4802025	c.1603C>A	p.P535T	Substitution - Missense	Liver
COSM1675577	c.2499A>G	p.I833M	Substitution - Missense	Large_intestine
COSM1703073	c.2105C>T	p.P702L	Substitution - Missense	Skin
COSM5899608	c.1753C>T	p.L585F	Substitution - Missense	Skin
COSM3665503	c.1292A>T	p.N431I	Substitution - Missense	Liver
COSM915022	c.2039T>C	p.V680A	Substitution - Missense	Endometrium
COSM4531832	c.182G>A	p.G61E	Substitution - Missense	Skin
COSM4011746	c.966G>C	p.K322N	Substitution - Missense	Stomach
COSM683247	c.3303G>T	p.E1101D	Substitution - Missense	Lung
COSM3866546	c.1082G>A	p.R361K	Substitution - Missense	Skin
COSM3434300	c.2799G>A	p.T933T	Substitution - coding silent	Skin
COSM4856161	c.3041G>A	p.G1014E	Substitution - Missense	Cervix
COSM3434285	c.309G>A	p.R103R	Substitution - coding silent	Skin
COSM4400036	c.1628C>T	p.A543V	Substitution - Missense	Skin
COSM683248	c.2547G>C	p.Q849H	Substitution - Missense	Lung
COSM145999	c.195C>A	p.N65K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3434287	c.533C>T	p.S178L	Substitution - Missense	Skin
COSM3434286	c.446C>T	p.S149F	Substitution - Missense	Skin
COSM3434302	c.3145C>T	p.P1049S	Substitution - Missense	Skin
COSM5935650	c.130C>T	p.P44S	Substitution - Missense	Skin
COSM5370101	c.165G>A	p.L55L	Substitution - coding silent	Upper_aerodigestive_tract
COSM5769134	c.1669C>G	p.Q557E	Substitution - Missense	Breast
COSM1134968	c.766A>T	p.R256*	Substitution - Nonsense	Kidney
COSM229173	c.2078C>T	p.P693L	Substitution - Missense	Skin
COSM5039895	c.2084G>A	p.G695D	Substitution - Missense	Liver
COSM4528650	c.1553G>A	p.R518Q	Substitution - Missense	Skin
COSM3434293	c.1369G>A	p.E457K	Substitution - Missense	Skin
COSM5739043	c.2313_2314insT	p.A774fs*3	Insertion - Frameshift	Small_intestine
COSM5370103	c.807G>A	p.T269T	Substitution - coding silent	Oesophagus
COSM1675578	c.2803G>A	p.E935K	Substitution - Missense	Skin
COSM4732892	c.1763T>C	p.M588T	Substitution - Missense	Large_intestine
COSM4902630	c.154A>G	p.N52D	Substitution - Missense	Skin
COSM1321526	c.2479C>T	p.R827W	Substitution - Missense	Large_intestine
COSM915017	c.1656C>T	p.F552F	Substitution - coding silent	Large_intestine
COSM3434289	c.922G>A	p.E308K	Substitution - Missense	Skin
COSM3434297	c.1943C>T	p.S648F	Substitution - Missense	Skin
COSM4932535	c.217A>T	p.T73S	Substitution - Missense	Liver

> Text Mining based Variations [ TOP ]
There is no record for TDRD1.

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BRCA	Breast invasive carcinoma	112	1100	-1.073	-2.702	-1.252	5.74e-05	Under
ESCA	Esophageal carcinoma	11	185	-0.105	-3.905	-3.106	0.000908	Under
HNSC	Head and Neck squamous cell carcinoma	44	522	-1.136	-3.682	-1.834	7.56e-06	Under
KIRC	Kidney renal clear cell carcinoma	72	534	0.596	-4.086	-4.458	1.8e-56	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	0.612	-3.235	-3.413	2.2e-10	Under
LUAD	Lung adenocarcinoma	59	517	-2.7	-3.132	-0.033	0.937	NS
PAAD	Pancreatic adenocarcinoma	4	179	0.02	-2.383	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	-2.519	2.944	4.166	1.18e-17	Over
STAD	Stomach adenocarcinoma	35	415	-2.993	-3.197	-0.186	0.711	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	1.032	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-2.561	-3.454	-0.924	0.0165	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	3.2
Autonomic ganglia	CHP212	3.7
Autonomic ganglia	IMR32	3.6
Autonomic ganglia	KELLY	3.4
Autonomic ganglia	KPNRTBM1	3.3
Autonomic ganglia	KPNSI9S	3.4
Autonomic ganglia	KPNYN	3.3
Autonomic ganglia	MHHNB11	3.4
Autonomic ganglia	NB1	3.4
Autonomic ganglia	NH6	3.4
Autonomic ganglia	SHSY5Y	3.6
Autonomic ganglia	SIMA	4
Autonomic ganglia	SKNAS	4
Autonomic ganglia	SKNBE2	7.3
Autonomic ganglia	SKNDZ	3.7
Autonomic ganglia	SKNFI	3.4
Autonomic ganglia	SKNSH	3.7
Biliary tract	HUCCT1	3.6
Biliary tract	HUH28	4
Biliary tract	SNU1079	4
Biliary tract	SNU1196	3.7
Biliary tract	SNU245	8.7
Biliary tract	SNU308	3.5
Biliary tract	SNU478	4.2
Bone	143B	3.4
Bone	A673	3.8
Bone	CADOES1	3.7
Bone	CAL78	3.5
Bone	G292CLONEA141B1	3.5
Bone	HOS	3.5
Bone	HS706T	3.7
Bone	HS737T	3.5
Bone	HS819T	3.8
Bone	HS821T	3.5
Bone	HS822T	3.4
Bone	HS863T	3.2
Bone	HS870T	3.5
Bone	HS888T	3.4
Bone	MG63	3.6
Bone	MHHES1	3.5
Bone	OUMS27	3.7
Bone	RDES	3.9
Bone	SJSA1	3.6
Bone	SKES1	7
Bone	SKNMC	3.6
Bone	SW1353	3.3
Bone	T173	3.6
Bone	TC71	3.6
Bone	U2OS	3.6
Breast	AU565	7.5
Breast	BT20	3.8
Breast	BT474	3.4
Breast	BT483	3.8
Breast	BT549	3.9
Breast	CAL120	3.6
Breast	CAL148	3.4
Breast	CAL51	3.5
Breast	CAL851	3.8
Breast	CAMA1	3.6
Breast	DU4475	3.9
Breast	EFM192A	3.7
Breast	EFM19	4.2
Breast	EVSAT	4.2
Breast	HCC1143	3.5
Breast	HCC1187	4.6
Breast	HCC1395	3.5
Breast	HCC1419	3.4
Breast	HCC1428	7.7
Breast	HCC1500	3
Breast	HCC1569	3.9
Breast	HCC1599	3.2
Breast	HCC1806	3.9
Breast	HCC1937	4.1
Breast	HCC1954	7.1
Breast	HCC202	3.4
Breast	HCC2157	3.4
Breast	HCC2218	7.7
Breast	HCC38	3.7
Breast	HCC70	7.5
Breast	HDQP1	3.8
Breast	HMC18	4
Breast	HS274T	4.5
Breast	HS281T	3.7
Breast	HS343T	3.5
Breast	HS578T	3.9
Breast	HS606T	3.4
Breast	HS739T	3.6
Breast	HS742T	3.7
Breast	JIMT1	3.3
Breast	KPL1	4.5
Breast	MCF7	5.1
Breast	MDAMB134VI	3.5
Breast	MDAMB157	3.5
Breast	MDAMB175VII	3.8
Breast	MDAMB231	4
Breast	MDAMB361	3.7
Breast	MDAMB415	3.6
Breast	MDAMB436	3.7
Breast	MDAMB453	4.1
Breast	MDAMB468	3.7
Breast	SKBR3	7.6
Breast	T47D	3.9
Breast	UACC812	3.9
Breast	UACC893	7.9
Breast	YMB1	3.7
Breast	ZR751	3.6
Breast	ZR7530	8.8
Central nervous system	1321N1	3.3
Central nervous system	42MGBA	3.4
Central nervous system	8MGBA	3.4
Central nervous system	A172	3.5
Central nervous system	AM38	3.7
Central nervous system	BECKER	3.5
Central nervous system	CAS1	3.5
Central nervous system	CCFSTTG1	3.5
Central nervous system	D283MED	3.6
Central nervous system	D341MED	3.4
Central nervous system	DAOY	3.9
Central nervous system	DBTRG05MG	3.3
Central nervous system	DKMG	3.8
Central nervous system	GAMG	3.4
Central nervous system	GB1	3.2
Central nervous system	GI1	3.6
Central nervous system	GMS10	3.6
Central nervous system	GOS3	3.8
Central nervous system	H4	3.8
Central nervous system	HS683	3.7
Central nervous system	KALS1	3.3
Central nervous system	KG1C	3.4
Central nervous system	KNS42	3.4
Central nervous system	KNS60	3.4
Central nervous system	KNS81	3.2
Central nervous system	KS1	3.2
Central nervous system	LN18	3.4
Central nervous system	LN229	3.6
Central nervous system	M059K	3.7
Central nervous system	MOGGCCM	3.1
Central nervous system	MOGGUVW	3.6
Central nervous system	NMCG1	3.3
Central nervous system	ONS76	3.3
Central nervous system	SF126	3.6
Central nervous system	SF295	3.7
Central nervous system	SNB19	3.4
Central nervous system	SNU1105	3.9
Central nervous system	SNU201	3.5
Central nervous system	SNU466	3.7
Central nervous system	SNU489	3.3
Central nervous system	SNU626	3.9
Central nervous system	SNU738	3.9
Central nervous system	SW1088	3.8
Central nervous system	SW1783	3.3
Central nervous system	T98G	3.5
Central nervous system	TM31	3
Central nervous system	U118MG	3.3
Central nervous system	U138MG	3.4
Central nervous system	U251MG	3.5
Central nervous system	U87MG	3.5
Central nervous system	YH13	3.7
Central nervous system	YKG1	3.5
Endometrium	AN3CA	3.6
Endometrium	COLO684	3.4
Endometrium	EFE184	4
Endometrium	EN	3.9
Endometrium	ESS1	3.4
Endometrium	HEC108	3.7
Endometrium	HEC151	4.2
Endometrium	HEC1A	3.6
Endometrium	HEC1B	3.8
Endometrium	HEC251	4
Endometrium	HEC265	4.5
Endometrium	HEC50B	3.4
Endometrium	HEC59	4.4
Endometrium	HEC6	3.4
Endometrium	ISHIKAWAHERAKLIO02ER	4.1
Endometrium	JHUEM1	3.7
Endometrium	JHUEM2	8.7
Endometrium	JHUEM3	3.3
Endometrium	KLE	3.9
Endometrium	MFE280	4.4
Endometrium	MFE296	4.2
Endometrium	MFE319	4.2
Endometrium	RL952	3.9
Endometrium	SNGM	3.6
Endometrium	SNU1077	3.3
Endometrium	SNU685	3.6
Endometrium	TEN	3.6
Haematopoietic and lymphoid	697	3.4
Haematopoietic and lymphoid	A3KAW	4.2
Haematopoietic and lymphoid	A4FUK	3.6
Haematopoietic and lymphoid	ALLSIL	3.1
Haematopoietic and lymphoid	AML193	3.5
Haematopoietic and lymphoid	AMO1	3.6
Haematopoietic and lymphoid	BCP1	3.7
Haematopoietic and lymphoid	BDCM	3.3
Haematopoietic and lymphoid	BL41	3.6
Haematopoietic and lymphoid	BL70	3.4
Haematopoietic and lymphoid	BV173	3.7
Haematopoietic and lymphoid	CA46	4.1
Haematopoietic and lymphoid	CI1	3.9
Haematopoietic and lymphoid	CMK115	3.3
Haematopoietic and lymphoid	CMK86	3.4
Haematopoietic and lymphoid	CMK	3.3
Haematopoietic and lymphoid	CMLT1	3.3
Haematopoietic and lymphoid	COLO775	4.2
Haematopoietic and lymphoid	DAUDI	3.9
Haematopoietic and lymphoid	DB	4.1
Haematopoietic and lymphoid	DEL	3.3
Haematopoietic and lymphoid	DND41	3.3
Haematopoietic and lymphoid	DOHH2	3.6
Haematopoietic and lymphoid	EB1	4
Haematopoietic and lymphoid	EB2	3.4
Haematopoietic and lymphoid	EHEB	3.4
Haematopoietic and lymphoid	EJM	3.7
Haematopoietic and lymphoid	EM2	3.5
Haematopoietic and lymphoid	EOL1	3.8
Haematopoietic and lymphoid	F36P	3.6
Haematopoietic and lymphoid	GA10	4
Haematopoietic and lymphoid	GDM1	4.1
Haematopoietic and lymphoid	GRANTA519	3.3
Haematopoietic and lymphoid	HDLM2	3.5
Haematopoietic and lymphoid	HDMYZ	3.3
Haematopoietic and lymphoid	HEL9217	4
Haematopoietic and lymphoid	HEL	3.7
Haematopoietic and lymphoid	HH	3.7
Haematopoietic and lymphoid	HL60	3.6
Haematopoietic and lymphoid	HPBALL	3.5
Haematopoietic and lymphoid	HS604T	3.4
Haematopoietic and lymphoid	HS611T	3.5
Haematopoietic and lymphoid	HS616T	3.7
Haematopoietic and lymphoid	HS751T	4.4
Haematopoietic and lymphoid	HT	4
Haematopoietic and lymphoid	HTK	4.1
Haematopoietic and lymphoid	HUNS1	4.1
Haematopoietic and lymphoid	HUT102	3.7
Haematopoietic and lymphoid	HUT78	3.5
Haematopoietic and lymphoid	JEKO1	3.6
Haematopoietic and lymphoid	JK1	3.2
Haematopoietic and lymphoid	JM1	3.3
Haematopoietic and lymphoid	JURKAT	3.6
Haematopoietic and lymphoid	JURLMK1	3.5
Haematopoietic and lymphoid	JVM2	3.4
Haematopoietic and lymphoid	JVM3	3.5
Haematopoietic and lymphoid	K562	4.3
Haematopoietic and lymphoid	KARPAS299	4.1
Haematopoietic and lymphoid	KARPAS422	3.1
Haematopoietic and lymphoid	KARPAS620	3.8
Haematopoietic and lymphoid	KASUMI1	4.3
Haematopoietic and lymphoid	KASUMI2	3.2
Haematopoietic and lymphoid	KASUMI6	3.4
Haematopoietic and lymphoid	KCL22	3.5
Haematopoietic and lymphoid	KE37	3.5
Haematopoietic and lymphoid	KE97	4.1
Haematopoietic and lymphoid	KG1	3.6
Haematopoietic and lymphoid	KHM1B	3.9
Haematopoietic and lymphoid	KIJK	3.6
Haematopoietic and lymphoid	KMH2	3.6
Haematopoietic and lymphoid	KMM1	6.2
Haematopoietic and lymphoid	KMS11	3.9
Haematopoietic and lymphoid	KMS12BM	4
Haematopoietic and lymphoid	KMS18	3.4
Haematopoietic and lymphoid	KMS20	4.2
Haematopoietic and lymphoid	KMS21BM	6.7
Haematopoietic and lymphoid	KMS26	3.7
Haematopoietic and lymphoid	KMS27	8.2
Haematopoietic and lymphoid	KMS28BM	3.7
Haematopoietic and lymphoid	KMS34	3.6
Haematopoietic and lymphoid	KO52	3.5
Haematopoietic and lymphoid	KOPN8	3.9
Haematopoietic and lymphoid	KU812	3.6
Haematopoietic and lymphoid	KYO1	4.4
Haematopoietic and lymphoid	L1236	3.6
Haematopoietic and lymphoid	L363	3.4
Haematopoietic and lymphoid	L428	3.6
Haematopoietic and lymphoid	L540	3.5
Haematopoietic and lymphoid	LAMA84	3.9
Haematopoietic and lymphoid	LOUCY	3.6
Haematopoietic and lymphoid	LP1	3.6
Haematopoietic and lymphoid	M07E	3.3
Haematopoietic and lymphoid	MC116	4.2
Haematopoietic and lymphoid	ME1	3.8
Haematopoietic and lymphoid	MEC1	3.4
Haematopoietic and lymphoid	MEC2	3.5
Haematopoietic and lymphoid	MEG01	3.8
Haematopoietic and lymphoid	MHHCALL2	3.7
Haematopoietic and lymphoid	MHHCALL3	4
Haematopoietic and lymphoid	MHHCALL4	3.2
Haematopoietic and lymphoid	MINO	3.6
Haematopoietic and lymphoid	MJ	4.2
Haematopoietic and lymphoid	MM1S	4.2
Haematopoietic and lymphoid	MOLM13	3.9
Haematopoietic and lymphoid	MOLM16	3.6
Haematopoietic and lymphoid	MOLM6	3.3
Haematopoietic and lymphoid	MOLP2	4
Haematopoietic and lymphoid	MOLP8	4.3
Haematopoietic and lymphoid	MOLT13	3.2
Haematopoietic and lymphoid	MOLT16	3
Haematopoietic and lymphoid	MOLT4	3.3
Haematopoietic and lymphoid	MONOMAC1	3.6
Haematopoietic and lymphoid	MONOMAC6	3.8
Haematopoietic and lymphoid	MOTN1	3.7
Haematopoietic and lymphoid	MUTZ5	3.5
Haematopoietic and lymphoid	MV411	3.9
Haematopoietic and lymphoid	NALM19	3.4
Haematopoietic and lymphoid	NALM1	3.2
Haematopoietic and lymphoid	NALM6	3.5
Haematopoietic and lymphoid	NAMALWA	4.3
Haematopoietic and lymphoid	NB4	4
Haematopoietic and lymphoid	NCIH929	3.4
Haematopoietic and lymphoid	NCO2	3.2
Haematopoietic and lymphoid	NOMO1	3.4
Haematopoietic and lymphoid	NUDHL1	3.6
Haematopoietic and lymphoid	NUDUL1	3.9
Haematopoietic and lymphoid	OCIAML2	3.9
Haematopoietic and lymphoid	OCIAML3	3.6
Haematopoietic and lymphoid	OCIAML5	3.4
Haematopoietic and lymphoid	OCILY10	4.1
Haematopoietic and lymphoid	OCILY19	3.6
Haematopoietic and lymphoid	OCILY3	3.5
Haematopoietic and lymphoid	OCIM1	3.6
Haematopoietic and lymphoid	OPM2	3.4
Haematopoietic and lymphoid	P12ICHIKAWA	3.8
Haematopoietic and lymphoid	P31FUJ	3.5
Haematopoietic and lymphoid	P3HR1	4.2
Haematopoietic and lymphoid	PCM6	3.5
Haematopoietic and lymphoid	PEER	3.9
Haematopoietic and lymphoid	PF382	3.2
Haematopoietic and lymphoid	PFEIFFER	3.5
Haematopoietic and lymphoid	PL21	3.7
Haematopoietic and lymphoid	RAJI	3.8
Haematopoietic and lymphoid	RCHACV	3.9
Haematopoietic and lymphoid	REC1	3.4
Haematopoietic and lymphoid	REH	3.7
Haematopoietic and lymphoid	RI1	3.7
Haematopoietic and lymphoid	RL	4
Haematopoietic and lymphoid	RPMI8226	4.2
Haematopoietic and lymphoid	RPMI8402	3.5
Haematopoietic and lymphoid	RS411	4.3
Haematopoietic and lymphoid	SEM	3.7
Haematopoietic and lymphoid	SET2	4
Haematopoietic and lymphoid	SIGM5	3.6
Haematopoietic and lymphoid	SKM1	3.6
Haematopoietic and lymphoid	SKMM2	3.5
Haematopoietic and lymphoid	SR786	3.7
Haematopoietic and lymphoid	ST486	3.9
Haematopoietic and lymphoid	SUDHL10	3.6
Haematopoietic and lymphoid	SUDHL1	3.8
Haematopoietic and lymphoid	SUDHL4	3.2
Haematopoietic and lymphoid	SUDHL5	3.9
Haematopoietic and lymphoid	SUDHL6	4.3
Haematopoietic and lymphoid	SUDHL8	4.1
Haematopoietic and lymphoid	SUPB15	3.9
Haematopoietic and lymphoid	SUPHD1	3.5
Haematopoietic and lymphoid	SUPM2	4.2
Haematopoietic and lymphoid	SUPT11	3.5
Haematopoietic and lymphoid	SUPT1	3.6
Haematopoietic and lymphoid	TALL1	3.6
Haematopoietic and lymphoid	TF1	3.3
Haematopoietic and lymphoid	THP1	3.6
Haematopoietic and lymphoid	TO175T	3.3
Haematopoietic and lymphoid	TOLEDO	3.5
Haematopoietic and lymphoid	U266B1	4.3
Haematopoietic and lymphoid	U937	4.1
Haematopoietic and lymphoid	UT7	3.4
Haematopoietic and lymphoid	WSUDLCL2	5.9
Kidney	769P	3.6
Kidney	786O	3.8
Kidney	A498	3.8
Kidney	A704	3.3
Kidney	ACHN	3.7
Kidney	BFTC909	3.4
Kidney	CAKI1	3.6
Kidney	CAKI2	4.2
Kidney	CAL54	3.8
Kidney	KMRC1	3.9
Kidney	KMRC20	3.4
Kidney	KMRC2	3.5
Kidney	KMRC3	3.8
Kidney	OSRC2	7
Kidney	RCC10RGB	3.4
Kidney	SNU1272	3.7
Kidney	SNU349	4
Kidney	TUHR10TKB	3.5
Kidney	TUHR14TKB	3.8
Kidney	TUHR4TKB	3.7
Kidney	VMRCRCW	4.1
Kidney	VMRCRCZ	3.7
Large intestine	C2BBE1	3.8
Large intestine	CCK81	4.2
Large intestine	CL11	3.5
Large intestine	CL14	3.6
Large intestine	CL34	3.6
Large intestine	CL40	3.9
Large intestine	COLO205	3.5
Large intestine	COLO320	3.5
Large intestine	COLO678	3.4
Large intestine	CW2	3.6
Large intestine	DLD1	3.7
Large intestine	GP2D	4.6
Large intestine	HCC56	4.1
Large intestine	HCT116	3.9
Large intestine	HCT15	4.2
Large intestine	HS675T	3.4
Large intestine	HS698T	3.3
Large intestine	HT115	3.6
Large intestine	HT29	3.8
Large intestine	HT55	4.1
Large intestine	KM12	3.7
Large intestine	LOVO	3.4
Large intestine	LS1034	3.4
Large intestine	LS123	3.9
Large intestine	LS180	3.4
Large intestine	LS411N	3.3
Large intestine	LS513	4
Large intestine	MDST8	3.9
Large intestine	NCIH508	3.9
Large intestine	NCIH716	3.9
Large intestine	NCIH747	3.5
Large intestine	OUMS23	3.4
Large intestine	RCM1	3.6
Large intestine	RKO	3.9
Large intestine	SKCO1	3.8
Large intestine	SNU1040	4
Large intestine	SNU1197	3.6
Large intestine	SNU175	4.1
Large intestine	SNU283	4
Large intestine	SNU407	3.6
Large intestine	SNU503	3.6
Large intestine	SNU61	3.6
Large intestine	SNU81	3.3
Large intestine	SNUC1	3.7
Large intestine	SNUC2A	3.4
Large intestine	SNUC4	3.7
Large intestine	SNUC5	3.4
Large intestine	SW1116	3.4
Large intestine	SW1417	3.5
Large intestine	SW1463	3.8
Large intestine	SW403	3.5
Large intestine	SW480	4.4
Large intestine	SW48	3.5
Large intestine	SW620	3.6
Large intestine	SW837	3.7
Large intestine	SW948	3.2
Large intestine	T84	3.7
Liver	ALEXANDERCELLS	4
Liver	C3A	3.6
Liver	HEP3B217	4.2
Liver	HEPG2	3.4
Liver	HLE	3.6
Liver	HLF	3.5
Liver	HUH1	4
Liver	HUH6	3.7
Liver	HUH7	3.7
Liver	JHH1	4.5
Liver	JHH2	3.8
Liver	JHH4	3.3
Liver	JHH5	3.6
Liver	JHH6	3.8
Liver	JHH7	7.2
Liver	LI7	3.4
Liver	PLCPRF5	4
Liver	SKHEP1	3.8
Liver	SNU182	3.6
Liver	SNU387	3.4
Liver	SNU398	3.6
Liver	SNU423	3.6
Liver	SNU449	3.9
Liver	SNU475	3.7
Liver	SNU761	3.3
Liver	SNU878	4
Liver	SNU886	3.8
Lung	A549	3.9
Lung	ABC1	3.2
Lung	BEN	3.8
Lung	CAL12T	3.6
Lung	CALU1	3.6
Lung	CALU3	3.8
Lung	CALU6	4.7
Lung	CHAGOK1	3.7
Lung	COLO668	3.5
Lung	COLO699	3.3
Lung	CORL105	3.5
Lung	CORL23	3.4
Lung	CORL24	4
Lung	CORL279	3.4
Lung	CORL311	4.2
Lung	CORL47	3.9
Lung	CORL51	3.7
Lung	CORL88	4.5
Lung	CORL95	3.7
Lung	CPCN	4
Lung	DMS114	3.8
Lung	DMS153	3.1
Lung	DMS273	4.5
Lung	DMS454	7.3
Lung	DMS53	3.6
Lung	DMS79	3.5
Lung	DV90	3.7
Lung	EBC1	3.6
Lung	EPLC272H	4.4
Lung	HARA	3.8
Lung	HCC1171	3.3
Lung	HCC1195	6.7
Lung	HCC15	3.2
Lung	HCC2279	3.8
Lung	HCC2935	3.4
Lung	HCC33	3.5
Lung	HCC366	3.5
Lung	HCC4006	3.2
Lung	HCC44	7.1
Lung	HCC78	3.4
Lung	HCC827	3.3
Lung	HCC95	3.9
Lung	HLC1	3.7
Lung	HLFA	3.7
Lung	HS229T	3.4
Lung	HS618T	3.7
Lung	IALM	3.7
Lung	KNS62	4.1
Lung	LC1F	3.7
Lung	LC1SQSF	4
Lung	LCLC103H	3.6
Lung	LCLC97TM1	3.1
Lung	LK2	4.1
Lung	LOUNH91	5.4
Lung	LU65	3.2
Lung	LU99	3.8
Lung	LUDLU1	3.7
Lung	LXF289	4.7
Lung	MORCPR	4
Lung	NCIH1048	3.4
Lung	NCIH1092	4.2
Lung	NCIH1105	3.8
Lung	NCIH1155	3.4
Lung	NCIH1184	3.1
Lung	NCIH1299	3.9
Lung	NCIH1339	3.7
Lung	NCIH1341	3.7
Lung	NCIH1355	3.6
Lung	NCIH1373	3.7
Lung	NCIH1385	3.9
Lung	NCIH1395	4
Lung	NCIH1435	3.5
Lung	NCIH1436	3.9
Lung	NCIH1437	3.9
Lung	NCIH146	3.5
Lung	NCIH1563	3.6
Lung	NCIH1568	3.5
Lung	NCIH1573	4
Lung	NCIH1581	4.5
Lung	NCIH1618	3.7
Lung	NCIH1623	3.8
Lung	NCIH1648	4.1
Lung	NCIH1650	3.6
Lung	NCIH1651	4
Lung	NCIH1666	3.4
Lung	NCIH1693	7.1
Lung	NCIH1694	3.4
Lung	NCIH1703	3.3
Lung	NCIH1734	3.9
Lung	NCIH1755	3.8
Lung	NCIH1781	3.3
Lung	NCIH1792	4.1
Lung	NCIH1793	5.4
Lung	NCIH1836	3.8
Lung	NCIH1838	3.7
Lung	NCIH1869	3.6
Lung	NCIH1876	3.4
Lung	NCIH1915	3.5
Lung	NCIH1930	3.1
Lung	NCIH1944	3.7
Lung	NCIH1963	3.3
Lung	NCIH196	3.3
Lung	NCIH1975	3.4
Lung	NCIH2009	3.4
Lung	NCIH2023	3.8
Lung	NCIH2029	3.6
Lung	NCIH2030	3.7
Lung	NCIH2066	3.5
Lung	NCIH2081	3.8
Lung	NCIH2085	4
Lung	NCIH2087	3.3
Lung	NCIH209	3.6
Lung	NCIH2106	3.1
Lung	NCIH2110	3.8
Lung	NCIH211	3.9
Lung	NCIH2122	4.4
Lung	NCIH2126	3.9
Lung	NCIH2141	3.5
Lung	NCIH2170	3.6
Lung	NCIH2171	4
Lung	NCIH2172	4.5
Lung	NCIH2196	3.5
Lung	NCIH2227	3.2
Lung	NCIH2228	3.8
Lung	NCIH226	3.3
Lung	NCIH2286	3.5
Lung	NCIH2291	3.9
Lung	NCIH2342	7
Lung	NCIH2347	4.1
Lung	NCIH23	4.8
Lung	NCIH2405	3.4
Lung	NCIH2444	4
Lung	NCIH292	4.2
Lung	NCIH322	3.7
Lung	NCIH3255	3.6
Lung	NCIH358	3.9
Lung	NCIH441	6.8
Lung	NCIH446	3.6
Lung	NCIH460	3.4
Lung	NCIH510	3.9
Lung	NCIH520	3.9
Lung	NCIH522	3.6
Lung	NCIH524	3.8
Lung	NCIH526	3.7
Lung	NCIH596	4.1
Lung	NCIH647	3.5
Lung	NCIH650	4
Lung	NCIH661	3.5
Lung	NCIH69	3.5
Lung	NCIH727	3.3
Lung	NCIH810	3.5
Lung	NCIH82	3.5
Lung	NCIH838	3.2
Lung	NCIH841	3.5
Lung	NCIH854	3.8
Lung	NCIH889	3.7
Lung	PC14	4.1
Lung	RERFLCAD1	3.4
Lung	RERFLCAD2	3.8
Lung	RERFLCAI	3.7
Lung	RERFLCKJ	3.6
Lung	RERFLCMS	3.9
Lung	RERFLCSQ1	3.4
Lung	SBC5	3.4
Lung	SCLC21H	3.6
Lung	SHP77	3.6
Lung	SKLU1	3.9
Lung	SKMES1	4
Lung	SQ1	4
Lung	SW1271	4.2
Lung	SW1573	3.6
Lung	SW900	4.1
Lung	VMRCLCD	3.4
Lung	VMRCLCP	3.4
Oesophagus	COLO680N	3.4
Oesophagus	ECGI10	3.5
Oesophagus	KYSE140	3.6
Oesophagus	KYSE150	3.3
Oesophagus	KYSE180	3.9
Oesophagus	KYSE270	3.2
Oesophagus	KYSE30	4
Oesophagus	KYSE410	4
Oesophagus	KYSE450	3.8
Oesophagus	KYSE510	3.6
Oesophagus	KYSE520	4.3
Oesophagus	KYSE70	3.7
Oesophagus	OE19	3.8
Oesophagus	OE33	3.7
Oesophagus	TE10	3.8
Oesophagus	TE11	3.8
Oesophagus	TE14	3.1
Oesophagus	TE15	3.7
Oesophagus	TE1	3.5
Oesophagus	TE4	3.5
Oesophagus	TE5	3.7
Oesophagus	TE6	3.4
Oesophagus	TE8	3.3
Oesophagus	TE9	3.8
Oesophagus	TT	3.7
Ovary	59M	3.1
Ovary	A2780	3.7
Ovary	CAOV3	3.6
Ovary	CAOV4	4
Ovary	COLO704	3.4
Ovary	COV318	4.7
Ovary	COV362	3.9
Ovary	COV434	3.8
Ovary	COV504	3.4
Ovary	COV644	6.9
Ovary	EFO21	3.8
Ovary	EFO27	4.1
Ovary	ES2	3.4
Ovary	FUOV1	3.6
Ovary	HEYA8	3.9
Ovary	HS571T	3.4
Ovary	IGROV1	3.8
Ovary	JHOC5	3.6
Ovary	JHOM1	3.1
Ovary	JHOM2B	3.4
Ovary	JHOS2	3.8
Ovary	JHOS4	3.6
Ovary	KURAMOCHI	3.6
Ovary	MCAS	3.8
Ovary	NIHOVCAR3	3.7
Ovary	OAW28	4.3
Ovary	OAW42	3.9
Ovary	OC314	3.4
Ovary	OC316	3.6
Ovary	ONCODG1	3.3
Ovary	OV56	4.1
Ovary	OV7	4
Ovary	OV90	3.9
Ovary	OVCAR4	3.6
Ovary	OVCAR8	4.2
Ovary	OVISE	3.4
Ovary	OVK18	3.1
Ovary	OVKATE	3.8
Ovary	OVMANA	3.8
Ovary	OVSAHO	4
Ovary	OVTOKO	4.2
Ovary	RMGI	3.5
Ovary	RMUGS	3.9
Ovary	SKOV3	3.6
Ovary	SNU119	3.2
Ovary	SNU840	4
Ovary	SNU8	3.9
Ovary	TOV112D	3.7
Ovary	TOV21G	3.9
Ovary	TYKNU	3.9
Pancreas	ASPC1	3.8
Pancreas	BXPC3	3.9
Pancreas	CAPAN1	5.8
Pancreas	CAPAN2	3.6
Pancreas	CFPAC1	3.9
Pancreas	DANG	3.5
Pancreas	HPAC	3.9
Pancreas	HPAFII	3.5
Pancreas	HS766T	3.5
Pancreas	HUPT3	3.9
Pancreas	HUPT4	3.9
Pancreas	KCIMOH1	3.5
Pancreas	KLM1	3.5
Pancreas	KP2	3.9
Pancreas	KP3	3.8
Pancreas	KP4	3.7
Pancreas	L33	3.5
Pancreas	MIAPACA2	3.6
Pancreas	PANC0203	5.7
Pancreas	PANC0213	3.7
Pancreas	PANC0327	4.1
Pancreas	PANC0403	7.8
Pancreas	PANC0504	3.4
Pancreas	PANC0813	4.3
Pancreas	PANC1005	3.6
Pancreas	PANC1	3.8
Pancreas	PATU8902	3.5
Pancreas	PATU8988S	3.8
Pancreas	PATU8988T	3.7
Pancreas	PK1	3.9
Pancreas	PK45H	3.9
Pancreas	PK59	3.5
Pancreas	PL45	3.5
Pancreas	PSN1	3.5
Pancreas	QGP1	3.5
Pancreas	SNU213	3.1
Pancreas	SNU324	3.6
Pancreas	SNU410	5.9
Pancreas	SU8686	3.5
Pancreas	SUIT2	4.1
Pancreas	SW1990	3.7
Pancreas	T3M4	4.3
Pancreas	TCCPAN2	4.1
Pancreas	YAPC	3.6
Pleura	ACCMESO1	3.3
Pleura	DM3	3.5
Pleura	ISTMES1	3.3
Pleura	ISTMES2	3.6
Pleura	JL1	3.5
Pleura	MPP89	3.9
Pleura	MSTO211H	3.8
Pleura	NCIH2052	3.7
Pleura	NCIH2452	3.2
Pleura	NCIH28	3.8
Prostate	22RV1	3.3
Prostate	DU145	3.4
Prostate	LNCAPCLONEFGC	4.2
Prostate	MDAPCA2B	3.7
Prostate	NCIH660	6.2
Prostate	PC3	4.2
Prostate	VCAP	9.3
Salivary gland	A253	4.3
Salivary gland	YD15	3.7
Skin	A101D	3.6
Skin	A2058	3.6
Skin	A375	3.4
Skin	C32	3.4
Skin	CHL1	4.3
Skin	CJM	3.1
Skin	COLO679	3.4
Skin	COLO741	3.5
Skin	COLO783	4.2
Skin	COLO792	3.8
Skin	COLO800	3.7
Skin	COLO818	3.7
Skin	COLO829	3.3
Skin	COLO849	3.6
Skin	G361	3.6
Skin	GRM	3.6
Skin	HMCB	3.4
Skin	HS294T	3.9
Skin	HS600T	3.9
Skin	HS688AT	3.5
Skin	HS695T	4.2
Skin	HS839T	3.1
Skin	HS852T	3.4
Skin	HS895T	3.6
Skin	HS934T	3.4
Skin	HS936T	6.1
Skin	HS939T	3.5
Skin	HS940T	3.5
Skin	HS944T	3.9
Skin	HT144	3.8
Skin	IGR1	4.1
Skin	IGR37	3.5
Skin	IGR39	3.7
Skin	IPC298	3.6
Skin	K029AX	3.8
Skin	LOXIMVI	3.4
Skin	MALME3M	3.6
Skin	MDAMB435S	3.6
Skin	MELHO	4
Skin	MELJUSO	3.5
Skin	MEWO	3.9
Skin	RPMI7951	4.6
Skin	RVH421	3.4
Skin	SH4	3.8
Skin	SKMEL1	3.8
Skin	SKMEL24	3.6
Skin	SKMEL28	3.6
Skin	SKMEL2	3.7
Skin	SKMEL30	3.7
Skin	SKMEL31	3.8
Skin	SKMEL3	3.8
Skin	SKMEL5	3.7
Skin	UACC257	3.5
Skin	UACC62	6
Skin	WM115	3.6
Skin	WM1799	3.9
Skin	WM2664	3.4
Skin	WM793	3.5
Skin	WM88	3.5
Skin	WM983B	3.9
Small intestine	HUTU80	3.7
Soft tissue	A204	3.8
Soft tissue	G401	4.3
Soft tissue	G402	3.5
Soft tissue	GCT	3.9
Soft tissue	HS729	3.1
Soft tissue	HT1080	3.4
Soft tissue	KYM1	3.7
Soft tissue	MESSA	3.9
Soft tissue	RD	4.1
Soft tissue	RH30	4.6
Soft tissue	RH41	3.2
Soft tissue	RKN	3.8
Soft tissue	S117	3.4
Soft tissue	SJRH30	4
Soft tissue	SKLMS1	3.6
Soft tissue	SKUT1	3.6
Soft tissue	TE125T	3.6
Soft tissue	TE159T	3.2
Soft tissue	TE441T	3.2
Soft tissue	TE617T	3.5
Stomach	2313287	3.3
Stomach	AGS	3.5
Stomach	AZ521	3.7
Stomach	ECC10	3.7
Stomach	ECC12	3.6
Stomach	FU97	4.1
Stomach	GCIY	7.1
Stomach	GSS	7.1
Stomach	GSU	3.5
Stomach	HGC27	3.9
Stomach	HS746T	3.4
Stomach	HUG1N	3.4
Stomach	IM95	3.8
Stomach	KATOIII	3.5
Stomach	KE39	4.1
Stomach	LMSU	3.2
Stomach	MKN1	3.8
Stomach	MKN45	3.5
Stomach	MKN74	3.3
Stomach	MKN7	3.5
Stomach	NCCSTCK140	3.2
Stomach	NCIN87	3.7
Stomach	NUGC2	3.6
Stomach	NUGC3	4.2
Stomach	NUGC4	4
Stomach	OCUM1	4.1
Stomach	RERFGC1B	3.4
Stomach	SH10TC	4.1
Stomach	SNU16	3.7
Stomach	SNU1	3.8
Stomach	SNU216	3.7
Stomach	SNU520	3.6
Stomach	SNU5	3.7
Stomach	SNU601	3.5
Stomach	SNU620	3.2
Stomach	SNU668	3.5
Stomach	SNU719	4.1
Stomach	TGBC11TKB	3.4
Thyroid	8305C	3.6
Thyroid	8505C	3.3
Thyroid	BCPAP	3.6
Thyroid	BHT101	3.4
Thyroid	CAL62	3.3
Thyroid	CGTHW1	3.5
Thyroid	FTC133	3.7
Thyroid	FTC238	4
Thyroid	ML1	3.3
Thyroid	SW579	3.3
Thyroid	TT2609C02	3.2
Thyroid	TT	4
Upper aerodigestive tract	BHY	6.2
Upper aerodigestive tract	BICR16	4
Upper aerodigestive tract	BICR18	3.4
Upper aerodigestive tract	BICR22	4.3
Upper aerodigestive tract	BICR31	3.9
Upper aerodigestive tract	BICR56	4.2
Upper aerodigestive tract	BICR6	3.9
Upper aerodigestive tract	CAL27	3.4
Upper aerodigestive tract	CAL33	3.9
Upper aerodigestive tract	DETROIT562	3.8
Upper aerodigestive tract	FADU	4.2
Upper aerodigestive tract	HS840T	3.3
Upper aerodigestive tract	HSC2	4.5
Upper aerodigestive tract	HSC3	3.6
Upper aerodigestive tract	HSC4	3.7
Upper aerodigestive tract	PECAPJ15	4.3
Upper aerodigestive tract	PECAPJ34CLONEC12	3.9
Upper aerodigestive tract	PECAPJ41CLONED2	3.6
Upper aerodigestive tract	PECAPJ49	3.9
Upper aerodigestive tract	SCC15	3.4
Upper aerodigestive tract	SCC25	3.7
Upper aerodigestive tract	SCC4	3.5
Upper aerodigestive tract	SCC9	4.2
Upper aerodigestive tract	SNU1076	4.6
Upper aerodigestive tract	SNU1214	3.7
Upper aerodigestive tract	SNU46	3.6
Upper aerodigestive tract	SNU899	3.8
Upper aerodigestive tract	YD10B	3.7
Upper aerodigestive tract	YD38	4
Upper aerodigestive tract	YD8	3.5
Urinary tract	5637	3.8
Urinary tract	639V	3.6
Urinary tract	647V	3.8
Urinary tract	BC3C	3.6
Urinary tract	BFTC905	3.3
Urinary tract	CAL29	3.8
Urinary tract	HS172T	3.3
Urinary tract	HT1197	3.9
Urinary tract	HT1376	3.6
Urinary tract	J82	4.1
Urinary tract	JMSU1	3.6
Urinary tract	KMBC2	3.6
Urinary tract	KU1919	3.8
Urinary tract	RT11284	4.3
Urinary tract	RT112	3.7
Urinary tract	RT4	3.7
Urinary tract	SCABER	3.9
Urinary tract	SW1710	4.2
Urinary tract	SW780	3.2
Urinary tract	T24	3.9
Urinary tract	TCCSUP	3.6
Urinary tract	UMUC1	3.7
Urinary tract	UMUC3	3.5
Urinary tract	VMCUB1	3.5

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	0.2
Adrenal gland	0.1
Appendix	0.2
Bone marrow	0
Breast	0.4
Cerebral cortex	0.2
Cervix, uterine	0.2
Colon	0.1
Duodenum	0.2
Endometrium	0.2
Epididymis	0.1
Esophagus	0.2
Fallopian tube	0.3
Gallbladder	0.2
Heart muscle	0.3
Kidney	2.3
Liver	0.1
Lung	0.1
Lymph node	0.3
Ovary	0.5
Pancreas	0.1
Parathyroid gland	0
Placenta	0.1
Prostate	0.8
Rectum	0.1
Salivary gland	0
Seminal vesicle	0.2
Skeletal muscle	0
Skin	0.1
Small intestine	0.1
Smooth muscle	0.2
Spleen	0.8
Stomach	0.1
Testis	31.9
Thyroid gland	0.1
Tonsil	0.2
Urinary bladder	0.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27272765	Overexpression	Prostate Neoplasm	Among 131 primary prostate tumors which were primarily from European American patients, TDRD1 is over-expressed in 68% of samples, while ERG is overexpressed in 48% of samples, suggesting an additional ERG-independent mechanism of TDRD1 overexpression.
23555854	Overexpression	Prostate Carcinoma	Given the prevalence of ERG fusions, TDRD1 overexpression is a common alteration in human prostate cancer which may be exploited for diagnostic or therapeutic procedures.
23319146	Overexpression	Prostate Carcinoma	In late-stage prostate cancer, TDRD1 was also coexpressed with ERG overexpression, although a proportion of ERG-negative late-stage samples expressed TDRD1.
23135352	Overexpression	Prostate Carcinoma	Our analysis identified 12epigenetics-related genes with a more than 2-fold increase or decrease in expression and a p-value <0.01. In modera-tely differentiated tumors compared to normal glands of the peripheral zone, we found the genes, TDRD1, IGF2, DICER1, ADARB1, HILS1, GLMN and TRIM27, to be upregulated, whereas TNRC6A and DGCR8 were found to be downregulated.
22904677	Overexpression (hypomethylation)	Prostate Carcinoma	Interestingly, we demonstrate that the expression of TDRD1, the topmost overexpressed gene of our list of ERG-specific candidate targets, is inversely correlated with the methylation levels of a CpG island found at -66 bp of the transcription start site in PCa and that TDRD1 expression is regulated by direct binding of ERG to the CpG island in VCaP cells.

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BRCA	Breast invasive carcinoma	1075	0.137	7.02e-06	29.3	61.1	9.6	Neutral
ESCA	Esophageal carcinoma	183	-0.071	0.341	31.7	53.6	14.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.063	0.153	23.5	68.9	7.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.061	0.166	18.3	79.6	2.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.049	0.403	6.6	91	2.4	Neutral
LUAD	Lung adenocarcinoma	512	0.051	0.246	27.5	55.9	16.6	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.021	0.777	16.9	75.1	7.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.053	0.245	13.4	84.3	2.2	Neutral
STAD	Stomach adenocarcinoma	413	-0.021	0.673	19.4	63.9	16.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	-0.029	0.721	44	45.3	10.7	Loss
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.014	0.753	11.7	67.2	21	Neutral

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BRCA	Breast invasive carcinoma	-0.575	0	83	785	0.032	0.0502	NS/NA
ESCA	Esophageal carcinoma	-0.447	9.02e-11	9	185	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.522	0	20	522	0.002	0.000226	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.321	1.41e-09	24	319	0.005	0.514	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.51	0	23	275	0.057	0.888	NS/NA
LUAD	Lung adenocarcinoma	-0.517	0	21	456	0.028	0.223	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.579	0	4	179	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.884	0	35	498	-0.264	6.87e-11	Decreased
STAD	Stomach adenocarcinoma	-0.275	8.34e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.647	0	0	156	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.231	4.94e-07	34	431	0.009	0.241	NS/NA

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BRCA	Breast invasive carcinoma	521	9.26e-06	Significant	23000897
HNSC	Head and Neck squamous cell carcinoma	279	1.43e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00227	Significant	26536169
LUAD	Lung adenocarcinoma	230	4.58e-08	Significant	25079552
PRAD	Prostate adenocarcinoma	333	4.34e-28	Significant	26544944
STAD	Stomach adenocarcinoma	277	0.000458	Significant	25079317
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0706	NS	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BRCA	Breast invasive carcinoma	1079	1.016	0.943	NS
ESCA	Esophageal carcinoma	184	0.788	0.445	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.705	0.063	NS
KIRC	Kidney renal clear cell carcinoma	531	0.573	0.0111	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.66	0.311	NS
LUAD	Lung adenocarcinoma	502	0.742	0.15	NS
PAAD	Pancreatic adenocarcinoma	177	1.277	0.4	NS
PRAD	Prostate adenocarcinoma	497	1.504	0.641	NS
STAD	Stomach adenocarcinoma	388	1.454	0.0885	NS
TGCT	Testicular Germ Cell Tumors	134	1615474824.469	0.157	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.862	0.596	NS

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BRCA	Breast invasive carcinoma	1071	-0.025	0.417	NS
ESCA	Esophageal carcinoma	162	0.105	0.182	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.055	0.248	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.046	0.287	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.173	0.00512	Lower
LUAD	Lung adenocarcinoma	507	-0.015	0.744	NS
PAAD	Pancreatic adenocarcinoma	176	0.074	0.331	NS
STAD	Stomach adenocarcinoma	392	0.065	0.197	NS
TGCT	Testicular Germ Cell Tumors	81	-0.079	0.482	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.009	0.849	NS

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
HNSC	Head and Neck squamous cell carcinoma	498	-0.015	0.742	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.031	0.472	NS
PAAD	Pancreatic adenocarcinoma	176	0.011	0.884	NS
STAD	Stomach adenocarcinoma	406	0.042	0.399	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.183	2.19e-05	Lower

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TDRD1.

Summary
Symbol	TDRD1
Name	tudor domain containing 1
Aliases	CT41.1; cancer/testis antigen 41.1; tudor domain containing protein 1; Tudor domain-containing protein 1
Location	10q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for TDRD1.

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27272765	Prostate Neoplasm	upstream	ERG	Regulation	As an ERG target gene, TDRD1 might play an important role in human prostate cancer development, and as a cancer/testis antigen, TDRD1 might have long-term potential to be a therapeutic target for prostate cancer immunotherapy.
23555854	Prostate Carcinoma	upstream	ERG	Positive regulation	By manipulation of ERG dosage through gene silencing and forced expression we show that ERG governs loss of DNA methylation at the TDRD1 promoter-associated CpG island, leading to TDRD1 overexpression.
23319146	Prostate Carcinoma	upstream	ERG	Positive regulation	In late-stage prostate cancer, TDRD1 was also coexpressed with ERG overexpression, although a proportion of ERG-negative late-stage samples expressed TDRD1. line VCaP, downregulation of ERG by shRNA lead to a lower expression level of TDRD1 and resulted in a decreased activity of the TDRD1 promoter. Our findings show TDRD1 as the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer.
22904677	Prostate Carcinoma	upstream	ERG	Regulation	Interestingly, we demonstrate that the expression of TDRD1, the topmost overexpressed gene of our list of ERG-specific candidate targets, is inversely correlated with the methylation levels of a CpG island found at -66 bp of the transcription start site in PCa and that TDRD1 expression is regulated by direct binding of ERG to the CpG island in VCaP cells.