Browse TDRD12 in pancancer

Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF00270 DEAD/DEAH box helicase
PF00567 Tudor domain
Function

Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.

Classification
Class Modification Substrate Product PubMed
# # # # #
> Gene Ontology
 
Biological Process GO:0006304 DNA modification
GO:0006305 DNA alkylation
GO:0006306 DNA methylation
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0007126 meiotic nuclear division
GO:0007140 male meiosis
GO:0007283 spermatogenesis
GO:0009566 fertilization
GO:0010501 RNA secondary structure unwinding
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016458 gene silencing
GO:0031047 gene silencing by RNA
GO:0032259 methylation
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0034587 piRNA metabolic process
GO:0043046 DNA methylation involved in gamete generation
GO:0043414 macromolecule methylation
GO:0044728 DNA methylation or demethylation
GO:0048232 male gamete generation
GO:0051222 positive regulation of protein transport
GO:0051321 meiotic cell cycle
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0090316 positive regulation of intracellular protein transport
GO:1903046 meiotic cell cycle process
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0008026 ATP-dependent helicase activity
GO:0008186 RNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0070035 purine NTP-dependent helicase activity
Cellular Component GO:1990923 PET complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
There is no record for TDRD12.
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
There is no record for TDRD12.
> Text Mining based Variations
 
There is no record for TDRD12.
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
There is no PTM data
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BRCABreast invasive carcinoma1121100-3.083-3.961-0.8650.0019Under
CESCCervical and endocervical cancers3306-2.904-5.455NANANA
LUSCLung squamous cell carcinoma51501-5.721-4.461.4930.000485Over
OVOvarian serous cystadenocarcinoma0307NA-4.467NANANA
PCPGPheochromocytoma and Paraganglioma3184-3.262-4.636NANANA
SKCMSkin Cutaneous Melanoma1472-6.834-5.144NANANA
TGCTTesticular Germ Cell Tumors0156NA3.772NANANA
THCAThyroid carcinoma59509-3.021-5.074-1.9756.66e-11Under
THYMThymoma2120-3.547-4.323NANANA
UCECUterine Corpus Endometrial Carcinoma35546-3.984-4.047-0.1040.82NS
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 0.1
Adrenal gland 0.6
Appendix 0.2
Bone marrow 0
Breast 0.1
Cerebral cortex 0.1
Cervix, uterine 0.4
Colon 0
Duodenum 0
Endometrium 1.1
Epididymis 3.6
Esophagus 0
Fallopian tube 0.6
Gallbladder 0.1
Heart muscle 0
Kidney 0
Liver 0
Lung 0.1
Lymph node 0.1
Ovary 1.3
Pancreas 0
Parathyroid gland 0
Placenta 0
Prostate 0.2
Rectum 0.1
Salivary gland 0
Seminal vesicle 0.2
Skeletal muscle 0
Skin 0.6
Small intestine 0.5
Smooth muscle 0.1
Spleen 0.1
Stomach 0
Testis 25.3
Thyroid gland 0.5
Tonsil 0.1
Urinary bladder 0.1
> Text Mining based Expression
 
There is no record.
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BRCABreast invasive carcinoma10750.1170.000121146125Neutral
CESCCervical and endocervical cancers2920.1310.02579.961.628.4Neutral
LUSCLung squamous cell carcinoma4980.2434.07e-0816.739.643.8Gain
OVOvarian serous cystadenocarcinoma3000.3372.12e-0917.336.346.3Gain
PCPGPheochromocytoma and Paraganglioma1620.0350.6593.787.78.6Neutral
SKCMSkin Cutaneous Melanoma3670.2511.07e-0620.262.717.2Neutral
TGCTTesticular Germ Cell Tumors1500.5092.89e-1133.346.720Neutral
THCAThyroid carcinoma4970.0640.1550.497.62Neutral
THYMThymoma1190.2580.004582.5952.5Neutral
UCECUterine Corpus Endometrial Carcinoma5370.3351.46e-157.474.717.9Neutral
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BRCABreast invasive carcinoma-0.4910837850.0150.156NS/NA
CESCCervical and endocervical cancers-0.271.62e-063306NANANS/NA
LUSCLung squamous cell carcinoma-0.3261.01e-108370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.3670.33609NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.3131.38e-053184NANANS/NA
SKCMSkin Cutaneous Melanoma-0.37901471NANANS/NA
TGCTTesticular Germ Cell Tumors-0.83100156NANANS/NA
THCAThyroid carcinoma-0.4340505090.0250.054NS/NA
THYMThymoma-0.5026.37e-092120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.3415.65e-14344310.0220.104NS/NA
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 
There is no antibody staining data.
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BRCABreast invasive carcinoma5210.0526NS23000897
LUSCLung squamous cell carcinoma1780.000453Significant22960745
OVOvarian serous cystadenocarcinoma2870.00658Significant21720365
SKCMSkin Cutaneous Melanoma3150.617NS26091043
THCAThyroid carcinoma3910.866NS25417114
UCECUterine Corpus Endometrial Carcinoma2321.47e-05Significant23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BRCABreast invasive carcinoma1079 1.060.798NS
CESCCervical and endocervical cancers291 1.7960.0967NS
LUSCLung squamous cell carcinoma494 1.0810.705NS
OVOvarian serous cystadenocarcinoma303 1.1220.584NS
PCPGPheochromocytoma and Paraganglioma179 00.164NS
SKCMSkin Cutaneous Melanoma459 1.3840.0836NS
TGCTTesticular Germ Cell Tumors134 1.2290.884NS
THCAThyroid carcinoma500 0.5040.242NS
THYMThymoma119 0.2440.173NS
UCECUterine Corpus Endometrial Carcinoma543 1.9660.0258Shorter
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BRCABreast invasive carcinoma1071 -0.0080.8NS
CESCCervical and endocervical cancers167 -0.0220.777NS
LUSCLung squamous cell carcinoma497 -0.0010.978NS
OVOvarian serous cystadenocarcinoma302 -0.0530.354NS
SKCMSkin Cutaneous Melanoma410 0.0840.0893NS
TGCTTesticular Germ Cell Tumors81 -0.4699.87e-06Lower
THCAThyroid carcinoma499 -0.0610.173NS
UCECUterine Corpus Endometrial Carcinoma501 0.060.182NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 0.0870.154NS
OVOvarian serous cystadenocarcinoma296 0.0620.287NS
UCECUterine Corpus Endometrial Carcinoma534 0.0810.0603NS
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for TDRD12.
Summary
SymbolTDRD12
Nametudor domain containing 12
Aliases ECAT8; FLJ13072; ES cell associated transcript 8; ES cell-associated transcript 8 protein; tudor domain-cont ......
Location19q13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for TDRD12.
> Interactions from Text Mining
 
There is no record for TDRD12.