CR2Cancer

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00628 PHD-finger
PF00643 B-box zinc finger
PF14634 zinc-RING finger domain

Function

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0001701 in utero embryonic development GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0003401 axis elongation GO:0006282 regulation of DNA repair GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007265 Ras protein signal transduction GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0016458 gene silencing GO:0016925 protein sumoylation GO:0017038 protein import GO:0018205 peptidyl-lysine modification GO:0019058 viral life cycle GO:0019076 viral release from host cell GO:0019079 viral genome replication GO:0031935 regulation of chromatin silencing GO:0031937 positive regulation of chromatin silencing GO:0032259 methylation GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034504 protein localization to nucleus GO:0035510 DNA dealkylation GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate GO:0039694 viral RNA genome replication GO:0039703 RNA replication GO:0040029 regulation of gene expression, epigenetic GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042993 positive regulation of transcription factor import into nucleus GO:0043045 DNA methylation involved in embryo development GO:0043388 positive regulation of DNA binding GO:0043414 macromolecule methylation GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0044706 multi-multicellular organism process GO:0044728 DNA methylation or demethylation GO:0044744 protein targeting to nucleus GO:0045069 regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045739 positive regulation of DNA repair GO:0045814 negative regulation of gene expression, epigenetic GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0046777 protein autophosphorylation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048525 negative regulation of viral process GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048762 mesenchymal cell differentiation GO:0050792 regulation of viral process GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051259 protein oligomerization GO:0060026 convergent extension GO:0060028 convergent extension involved in axis elongation GO:0060485 mesenchyme development GO:0060560 developmental growth involved in morphogenesis GO:0060669 embryonic placenta morphogenesis GO:0060968 regulation of gene silencing GO:0061458 reproductive system development GO:0070988 demethylation GO:0071514 genetic imprinting GO:0080111 DNA demethylation GO:0090308 regulation of methylation-dependent chromatin silencing GO:0090309 positive regulation of methylation-dependent chromatin silencing GO:0090316 positive regulation of intracellular protein transport GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901535 regulation of DNA demethylation GO:1901536 negative regulation of DNA demethylation GO:1901538 changes to DNA methylation involved in embryo development GO:1902186 regulation of viral release from host cell GO:1902187 negative regulation of viral release from host cell GO:1902275 regulation of chromatin organization GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:1905269 positive regulation of chromatin organization GO:2000653 regulation of genetic imprinting GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus
Molecular Function	GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031625 ubiquitin protein ligase binding GO:0035851 Krueppel-associated box domain binding GO:0044389 ubiquitin-like protein ligase binding GO:0070087 chromo shadow domain binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding GO:1990841 promoter-specific chromatin binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0005667 transcription factor complex GO:0005719 nuclear euchromatin GO:0005720 nuclear heterochromatin GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3757368	c.2148C>T	p.P716P	Substitution - coding silent	Large_intestine
COSM6003893	c.2205T>C	p.G735G	Substitution - coding silent	Prostate
COSM6003782	c.2439G>A	p.P813P	Substitution - coding silent	Prostate
COSM5640904	c.1915A>T	p.M639L	Substitution - Missense	Oesophagus
COSM4953357	c.610G>T	p.E204*	Substitution - Nonsense	Liver
COSM2974789	c.1663G>C	p.E555Q	Substitution - Missense	Stomach
COSM308173	c.1475G>T	p.R492L	Substitution - Missense	Biliary_tract
COSM95402	c.1846G>A	p.G616S	Substitution - Missense	Lung
COSM341171	c.429C>T	p.A143A	Substitution - coding silent	Lung
COSM3540827	c.1251A>C	p.S417S	Substitution - coding silent	Skin
COSM3938352	c.2194-2A>T	p.?	Unknown	Oesophagus
COSM2974771	c.1205C>T	p.A402V	Substitution - Missense	Large_intestine
COSM5391021	c.950C>T	p.A317V	Substitution - Missense	Skin
COSM171193	c.2116C>T	p.R706C	Substitution - Missense	Large_intestine
COSM3836057	c.2016C>T	p.L672L	Substitution - coding silent	Breast
COSM4082480	c.2228T>C	p.I743T	Substitution - Missense	Stomach
COSM6017780	c.2307C>T	p.F769F	Substitution - coding silent	Skin
COSM4792076	c.1005G>T	p.M335I	Substitution - Missense	Liver
COSM271572	c.2111G>A	p.C704Y	Substitution - Missense	Large_intestine
COSM4845605	c.2046C>T	p.L682L	Substitution - coding silent	Cervix
COSM440561	c.1128C>G	p.L376L	Substitution - coding silent	Breast
COSM3836056	c.523G>A	p.E175K	Substitution - Missense	Breast
COSM5391022	c.1569A>C	p.E523D	Substitution - Missense	Skin
COSM4958951	c.588G>A	p.G196G	Substitution - coding silent	Liver
COSM5015651	c.2084A>G	p.K695R	Substitution - Missense	Kidney
COSM1681474	c.544C>T	p.Q182*	Substitution - Nonsense	Lung
COSM4954279	c.530G>C	p.C177S	Substitution - Missense	Liver
COSM1190189	c.1325C>T	p.P442L	Substitution - Missense	Soft_tissue
COSM440562	c.1234C>T	p.R412C	Substitution - Missense	Breast
COSM2974806	c.2237G>A	p.R746H	Substitution - Missense	Large_intestine
COSM4523160	c.1200G>A	p.K400K	Substitution - coding silent	Skin
COSM1002779	c.899T>A	p.L300Q	Substitution - Missense	Endometrium
COSM2974800	c.2143G>A	p.E715K	Substitution - Missense	Large_intestine
COSM1002774	c.382G>T	p.D128Y	Substitution - Missense	Endometrium
COSM440561	c.1128C>G	p.L376L	Substitution - coding silent	Prostate
COSM4651397	c.1593C>T	p.T531T	Substitution - coding silent	Large_intestine
COSM4756145	c.2326A>C	p.T776P	Substitution - Missense	Stomach
COSM6003893	c.2205T>C	p.G735G	Substitution - coding silent	Prostate
COSM5786667	c.1387C>T	p.P463S	Substitution - Missense	Breast
COSM418733	c.1747G>A	p.E583K	Substitution - Missense	Urinary_tract
COSM4736018	c.2294T>G	p.V765G	Substitution - Missense	Large_intestine
COSM4082476	c.1030C>T	p.H344Y	Substitution - Missense	Stomach
COSM1613012	c.2067_2068insACTGGCG	p.V692fs*16	Insertion - Frameshift	Liver
COSM4399810	c.1842A>G	p.P614P	Substitution - coding silent	Skin
COSM4982750	c.1677G>C	p.E559D	Substitution - Missense	Oesophagus
COSM95401	c.1771C>T	p.R591C	Substitution - Missense	Breast
COSM95402	c.1846G>A	p.G616S	Substitution - Missense	Kidney
COSM4082473	c.525G>A	p.E175E	Substitution - coding silent	Stomach
COSM4891126	c.813G>C	p.Q271H	Substitution - Missense	Upper_aerodigestive_tract
COSM3371544	c.402C>A	p.F134L	Substitution - Missense	Thyroid
COSM3540828	c.1760C>T	p.A587V	Substitution - Missense	Skin
COSM4288486	c.2433G>C	p.E811D	Substitution - Missense	Upper_aerodigestive_tract
COSM392474	c.2434delC	p.P813fs*3	Deletion - Frameshift	Lung
COSM4994558	c.424G>A	p.A142T	Substitution - Missense	Large_intestine
COSM1190189	c.1325C>T	p.P442L	Substitution - Missense	Lung
COSM1713044	c.2153G>A	p.R718H	Substitution - Missense	Skin
COSM3726730	c.1395G>A	p.V465V	Substitution - coding silent	Lung
COSM4637832	c.1864G>A	p.D622N	Substitution - Missense	Large_intestine
COSM4082479	c.2085G>T	p.K695N	Substitution - Missense	Stomach
COSM2974766	c.870T>G	p.R290R	Substitution - coding silent	Large_intestine
COSM4607052	c.542A>G	p.H181R	Substitution - Missense	Adrenal_gland
COSM2974752	c.359G>A	p.C120Y	Substitution - Missense	Large_intestine
COSM1002776	c.393G>T	p.E131D	Substitution - Missense	Endometrium
COSM4127971	c.2347C>T	p.Q783*	Substitution - Nonsense	Ovary
COSM1002775	c.393G>A	p.E131E	Substitution - coding silent	Endometrium
COSM5707255	c.778G>A	p.V260M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5814332	c.174G>A	p.A58A	Substitution - coding silent	Liver
COSM4927780	c.2062G>T	p.D688Y	Substitution - Missense	Liver
COSM3743178	c.1049C>G	p.S350C	Substitution - Missense	Liver
COSM4082478	c.1886G>A	p.R629H	Substitution - Missense	Stomach
COSM4624144	c.990G>A	p.R330R	Substitution - coding silent	Large_intestine
COSM4736017	c.1963G>C	p.A655P	Substitution - Missense	Large_intestine
COSM2974758	c.706G>A	p.A236T	Substitution - Missense	Lung
COSM475425	c.1329G>A	p.M443I	Substitution - Missense	Kidney
COSM1002777	c.673G>A	p.D225N	Substitution - Missense	Endometrium
COSM1397351	c.2142C>T	p.H714H	Substitution - coding silent	Large_intestine
COSM3371544	c.402C>A	p.F134L	Substitution - Missense	Cervix
COSM1600242	c.865A>C	p.K289Q	Substitution - Missense	Central_nervous_system
COSM3540825	c.610G>A	p.E204K	Substitution - Missense	Skin
COSM3797647	c.517C>T	p.L173L	Substitution - coding silent	Urinary_tract
COSM4928244	c.1121G>A	p.R374Q	Substitution - Missense	Liver
COSM4581532	c.1020G>A	p.K340K	Substitution - coding silent	Bone
COSM5807765	c.1230A>T	p.A410A	Substitution - coding silent	Liver
COSM2974769	c.1134G>A	p.M378I	Substitution - Missense	Urinary_tract
COSM1002781	c.1147G>A	p.V383M	Substitution - Missense	Endometrium
COSM2974760	c.755A>T	p.Q252L	Substitution - Missense	Large_intestine
COSM3893789	c.791G>A	p.G264E	Substitution - Missense	Skin
COSM4082477	c.1583C>A	p.A528D	Substitution - Missense	Stomach
COSM5005134	c.1448G>A	p.R483H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4923283	c.545A>G	p.Q182R	Substitution - Missense	Liver
COSM714035	c.341-7C>T	p.?	Unknown	Liver
COSM2974803	c.2202C>T	p.P734P	Substitution - coding silent	Skin
COSM5947434	c.251T>A	p.L84*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1002784	c.2090C>A	p.S697*	Substitution - Nonsense	Endometrium
COSM5940955	c.341-5C>T	p.?	Unknown	Skin
COSM4463923	c.1310C>T	p.S437F	Substitution - Missense	Skin
COSM1564945	c.1611G>A	p.A537A	Substitution - coding silent	Large_intestine
COSM4288486	c.2433G>C	p.E811D	Substitution - Missense	Upper_aerodigestive_tract
COSM1002782	c.1569A>G	p.E523E	Substitution - coding silent	Endometrium
COSM3757367	c.1170G>A	p.K390K	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3757367	c.1170G>A	p.K390K	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM6003893	c.2205T>C	p.G735G	Substitution - coding silent	Prostate
COSM1002785	c.2120T>C	p.V707A	Substitution - Missense	Endometrium
COSM5494703	c.284C>T	p.A95V	Substitution - Missense	Biliary_tract
COSM4288486	c.2433G>C	p.E811D	Substitution - Missense	Upper_aerodigestive_tract
COSM3990373	c.521G>A	p.C174Y	Substitution - Missense	Kidney
COSM4958951	c.588G>A	p.G196G	Substitution - coding silent	Liver
COSM4082475	c.863A>G	p.Q288R	Substitution - Missense	Stomach
COSM3748700	c.1397C>G	p.S466*	Substitution - Nonsense	Stomach
COSM5684675	c.100A>C	p.T34P	Substitution - Missense	Soft_tissue
COSM6003893	c.2205T>C	p.G735G	Substitution - coding silent	Prostate
COSM440563	c.1310C>G	p.S437C	Substitution - Missense	Breast
COSM5498371	c.1642G>A	p.A548T	Substitution - Missense	Biliary_tract
COSM475424	c.461C>G	p.T154S	Substitution - Missense	Kidney
COSM4288486	c.2433G>C	p.E811D	Substitution - Missense	Upper_aerodigestive_tract
COSM4736014	c.1039C>T	p.R347C	Substitution - Missense	Large_intestine
COSM1713043	c.1570C>T	p.R524C	Substitution - Missense	Skin
COSM1002781	c.1147G>A	p.V383M	Substitution - Missense	Pancreas
COSM4736013	c.601C>T	p.R201W	Substitution - Missense	Large_intestine
COSM1002780	c.1122G>A	p.R374R	Substitution - coding silent	Endometrium
COSM4736016	c.1873G>C	p.A625P	Substitution - Missense	Large_intestine
COSM4082474	c.670T>C	p.C224R	Substitution - Missense	Stomach
COSM341803	c.1216+2T>A	p.?	Unknown	Lung
COSM4736019	c.2358C>T	p.I786I	Substitution - coding silent	Large_intestine
COSM4469298	c.1592C>T	p.T531I	Substitution - Missense	Skin
COSM3540826	c.1128C>T	p.L376L	Substitution - coding silent	Skin
COSM171193	c.2116C>T	p.R706C	Substitution - Missense	Large_intestine
COSM4527902	c.1498G>C	p.D500H	Substitution - Missense	Skin
COSM4288486	c.2433G>C	p.E811D	Substitution - Missense	Large_intestine
COSM2974780	c.1474C>T	p.R492C	Substitution - Missense	Skin
COSM5622043	c.845G>A	p.R282H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4953357	c.610G>T	p.E204*	Substitution - Nonsense	Liver
COSM4736015	c.1853C>T	p.P618L	Substitution - Missense	Large_intestine
COSM5521449	c.2193+3G>T	p.?	Unknown	Prostate
COSM1268524	c.2196C>A	p.D732E	Substitution - Missense	Oesophagus
COSM714032	c.2181C>T	p.S727S	Substitution - coding silent	Lung
COSM95400	c.252G>C	p.L84F	Substitution - Missense	Ovary
COSM5943473	c.1445delT	p.M482fs*7	Deletion - Frameshift	Skin
COSM5391020	c.649C>T	p.L217F	Substitution - Missense	Skin
COSM1268525	c.426T>G	p.A142A	Substitution - coding silent	Oesophagus
COSM3933225	c.1752T>G	p.G584G	Substitution - coding silent	Urinary_tract
COSM1002783	c.1926G>A	p.Q642Q	Substitution - coding silent	Endometrium
COSM1002778	c.889A>G	p.M297V	Substitution - Missense	Endometrium
COSM3757367	c.1170G>A	p.K390K	Substitution - coding silent	Large_intestine
COSM5343485	c.1102-8C>T	p.?	Unknown	Large_intestine
COSM1397350	c.1459C>T	p.R487*	Substitution - Nonsense	Large_intestine
COSM3757367	c.1170G>A	p.K390K	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5624419	c.1207G>A	p.E403K	Substitution - Missense	Oesophagus
COSM5365568	c.2104C>T	p.R702W	Substitution - Missense	Large_intestine
COSM5003231	c.858C>A	p.D286E	Substitution - Missense	Pancreas
COSM440564	c.2229C>T	p.I743I	Substitution - coding silent	Breast
COSM5817274	c.1201A>G	p.S401G	Substitution - Missense	Liver
COSM4792076	c.1005G>T	p.M335I	Substitution - Missense	Liver
COSM5744195	c.2381C>T	p.T794M	Substitution - Missense	Small_intestine
COSM4954279	c.530G>C	p.C177S	Substitution - Missense	Liver
COSM5959990	c.112G>T	p.A38S	Substitution - Missense	Thyroid

> Text Mining based Variations [ TOP ]
There is no record for TRIM28.

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13263	19	S	Phosphoserine	-	No	None detected
Q13263	26	S	Phosphoserine	-	No	None detected
Q13263	50	S	Phosphoserine	-	No	None detected
Q13263	138	S	Phosphoserine	-	No	None detected
Q13263	266	K	N6-acetyllysine	-	No	None detected
Q13263	304	K	N6-acetyllysine	-	No	None detected
Q13263	340	K	N6-acetyllysine	-	No	None detected
Q13263	377	K	N6-acetyllysine	-	No	None detected
Q13263	417	S	Phosphoserine	-	No	None detected
Q13263	437	S	Phosphoserine	-	Yes	p.S437C (cancer: BRCA)
Q13263	439	S	Phosphoserine	-	No	None detected
Q13263	453	S	Phosphoserine	-	No	None detected
Q13263	470	R	Citrulline	-	No	None detected
Q13263	471	S	Phosphoserine	-	No	None detected
Q13263	472	R	Citrulline	-	No	None detected
Q13263	473	S	Phosphoserine	-	No	None detected
Q13263	479	S	Phosphoserine	-	No	None detected
Q13263	489	S	Phosphoserine	-	No	None detected
Q13263	498	T	Phosphothreonine	-	No	None detected
Q13263	501	S	Phosphoserine	-	No	None detected
Q13263	541	T	Phosphothreonine	-	No	None detected
Q13263	594	S	Phosphoserine	-	No	None detected
Q13263	683	S	Phosphoserine	-	No	None detected
Q13263	689	S	Phosphoserine	-	No	None detected
Q13263	697	S	Phosphoserine	-	Yes	p.S697* (cancer: UCEC)
Q13263	752	S	Phosphoserine	-	No	None detected
Q13263	755	Y	Phosphotyrosine	-	Yes	p.Y755C (cancer: STAD)
Q13263	757	S	Phosphoserine	-	No	None detected
Q13263	770	K	N6-acetyllysine	-	No	None detected
Q13263	774	K	N6-acetyllysine	-	No	None detected
Q13263	779	K	N6-acetyllysine	-	No	None detected
Q13263	784	S	Phosphoserine	-	No	None detected
Q13263	824	S	Phosphoserine	ATM and ATR and dsDNA kinase	No	None detected

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	8.186	8.673	0.538	9.78e-05	NS
BRCA	Breast invasive carcinoma	112	1100	7.531	8.231	0.768	1.49e-38	Over
CESC	Cervical and endocervical cancers	3	306	8.37	8.717	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	7.91	8.688	0.854	1.57e-18	Over
ESCA	Esophageal carcinoma	11	185	7.773	8.529	0.626	0.00912	Over
GBM	Glioblastoma multiforme	5	166	7.433	8.166	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.885	8.316	0.466	6.34e-09	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.277	7.384	0.116	0.0281	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.638	7.569	-0.041	0.616	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.513	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.759	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.603	7.181	0.645	7.6e-11	Over
LUAD	Lung adenocarcinoma	59	517	7.539	7.998	0.483	9.27e-11	NS
LUSC	Lung squamous cell carcinoma	51	501	7.513	8.545	1.044	4.94e-29	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	8.798	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.73	7.79	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.583	7.645	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.872	8.201	0.367	2.78e-11	NS
READ	Rectum adenocarcinoma	10	167	7.732	8.7	1.072	1.62e-06	Over
SARC	Sarcoma	2	263	8.038	8	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.129	8.508	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.965	8.446	0.476	0.000127	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	10.146	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.792	8.036	0.235	1.27e-07	NS
THYM	Thymoma	2	120	8.69	9.05	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	8.51	8.963	0.457	3.01e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.2
Autonomic ganglia	CHP212	10.2
Autonomic ganglia	IMR32	11
Autonomic ganglia	KELLY	10.7
Autonomic ganglia	KPNRTBM1	10.7
Autonomic ganglia	KPNSI9S	10.4
Autonomic ganglia	KPNYN	10.4
Autonomic ganglia	MHHNB11	10.6
Autonomic ganglia	NB1	11.2
Autonomic ganglia	NH6	10.3
Autonomic ganglia	SHSY5Y	10.1
Autonomic ganglia	SIMA	11
Autonomic ganglia	SKNAS	10.6
Autonomic ganglia	SKNBE2	10.2
Autonomic ganglia	SKNDZ	9.8
Autonomic ganglia	SKNFI	9.3
Autonomic ganglia	SKNSH	10
Biliary tract	HUCCT1	10
Biliary tract	HUH28	10.1
Biliary tract	SNU1079	10.6
Biliary tract	SNU1196	11.4
Biliary tract	SNU245	11.4
Biliary tract	SNU308	10.8
Biliary tract	SNU478	11.7
Bone	143B	10.8
Bone	A673	11.2
Bone	CADOES1	10.8
Bone	CAL78	10
Bone	G292CLONEA141B1	9.5
Bone	HOS	10.2
Bone	HS706T	9.2
Bone	HS737T	9
Bone	HS819T	8.7
Bone	HS821T	9.8
Bone	HS822T	8.8
Bone	HS863T	9.8
Bone	HS870T	9.4
Bone	HS888T	10.1
Bone	MG63	10.7
Bone	MHHES1	10.2
Bone	OUMS27	9.6
Bone	RDES	10.6
Bone	SJSA1	10.3
Bone	SKES1	11.1
Bone	SKNMC	11.3
Bone	SW1353	9.8
Bone	T173	9
Bone	TC71	10.7
Bone	U2OS	10.4
Breast	AU565	10.8
Breast	BT20	9.3
Breast	BT474	10.5
Breast	BT483	10.2
Breast	BT549	10.9
Breast	CAL120	10.8
Breast	CAL148	10.8
Breast	CAL51	10.5
Breast	CAL851	10.5
Breast	CAMA1	10.2
Breast	DU4475	9.9
Breast	EFM192A	11.1
Breast	EFM19	9.5
Breast	EVSAT	10.5
Breast	HCC1143	11.1
Breast	HCC1187	10.8
Breast	HCC1395	10.1
Breast	HCC1419	10.4
Breast	HCC1428	11.1
Breast	HCC1500	10.2
Breast	HCC1569	9.7
Breast	HCC1599	8.9
Breast	HCC1806	12.6
Breast	HCC1937	10.8
Breast	HCC1954	9.5
Breast	HCC202	10.7
Breast	HCC2157	9.4
Breast	HCC2218	8.7
Breast	HCC38	9.9
Breast	HCC70	10.1
Breast	HDQP1	10.3
Breast	HMC18	9.9
Breast	HS274T	9.6
Breast	HS281T	9.9
Breast	HS343T	10
Breast	HS578T	10
Breast	HS606T	9.4
Breast	HS739T	9.2
Breast	HS742T	8.7
Breast	JIMT1	10.5
Breast	KPL1	10.9
Breast	MCF7	10.7
Breast	MDAMB134VI	9.9
Breast	MDAMB157	8.6
Breast	MDAMB175VII	9.5
Breast	MDAMB231	10.4
Breast	MDAMB361	10.9
Breast	MDAMB415	10.9
Breast	MDAMB436	10.7
Breast	MDAMB453	10.9
Breast	MDAMB468	11.2
Breast	SKBR3	10.4
Breast	T47D	9.1
Breast	UACC812	11.1
Breast	UACC893	10
Breast	YMB1	9.5
Breast	ZR751	9.4
Breast	ZR7530	10.4
Central nervous system	1321N1	10.2
Central nervous system	42MGBA	10.2
Central nervous system	8MGBA	9.7
Central nervous system	A172	10.5
Central nervous system	AM38	10.3
Central nervous system	BECKER	10.1
Central nervous system	CAS1	9.7
Central nervous system	CCFSTTG1	10.1
Central nervous system	D283MED	11.1
Central nervous system	D341MED	10.4
Central nervous system	DAOY	10.8
Central nervous system	DBTRG05MG	9.8
Central nervous system	DKMG	8.5
Central nervous system	GAMG	10.5
Central nervous system	GB1	11.6
Central nervous system	GI1	10
Central nervous system	GMS10	9.8
Central nervous system	GOS3	9.7
Central nervous system	H4	10.7
Central nervous system	HS683	9.5
Central nervous system	KALS1	10.1
Central nervous system	KG1C	9.4
Central nervous system	KNS42	10
Central nervous system	KNS60	9.3
Central nervous system	KNS81	9.5
Central nervous system	KS1	10.4
Central nervous system	LN18	10.6
Central nervous system	LN229	9.7
Central nervous system	M059K	10
Central nervous system	MOGGCCM	10.6
Central nervous system	MOGGUVW	10.1
Central nervous system	NMCG1	10.1
Central nervous system	ONS76	9.9
Central nervous system	SF126	9.8
Central nervous system	SF295	10.8
Central nervous system	SNB19	9.7
Central nervous system	SNU1105	10.2
Central nervous system	SNU201	10.1
Central nervous system	SNU466	9.9
Central nervous system	SNU489	10.5
Central nervous system	SNU626	9.6
Central nervous system	SNU738	10
Central nervous system	SW1088	10.6
Central nervous system	SW1783	9.7
Central nervous system	T98G	10.2
Central nervous system	TM31	9.5
Central nervous system	U118MG	11.2
Central nervous system	U138MG	10.8
Central nervous system	U251MG	9.7
Central nervous system	U87MG	10.7
Central nervous system	YH13	10.6
Central nervous system	YKG1	9.9
Endometrium	AN3CA	11
Endometrium	COLO684	12
Endometrium	EFE184	10.1
Endometrium	EN	10.5
Endometrium	ESS1	10.4
Endometrium	HEC108	9.7
Endometrium	HEC151	10.2
Endometrium	HEC1A	10.7
Endometrium	HEC1B	10.9
Endometrium	HEC251	9.1
Endometrium	HEC265	10.1
Endometrium	HEC50B	9.4
Endometrium	HEC59	10.5
Endometrium	HEC6	9.4
Endometrium	ISHIKAWAHERAKLIO02ER	9.9
Endometrium	JHUEM1	10.7
Endometrium	JHUEM2	10.2
Endometrium	JHUEM3	10
Endometrium	KLE	10.7
Endometrium	MFE280	10.6
Endometrium	MFE296	10.5
Endometrium	MFE319	11.1
Endometrium	RL952	10.2
Endometrium	SNGM	10.2
Endometrium	SNU1077	10.1
Endometrium	SNU685	11
Endometrium	TEN	10.2
Haematopoietic and lymphoid	697	11.1
Haematopoietic and lymphoid	A3KAW	9.7
Haematopoietic and lymphoid	A4FUK	10.4
Haematopoietic and lymphoid	ALLSIL	11.1
Haematopoietic and lymphoid	AML193	10.2
Haematopoietic and lymphoid	AMO1	10.7
Haematopoietic and lymphoid	BCP1	11.3
Haematopoietic and lymphoid	BDCM	10.1
Haematopoietic and lymphoid	BL41	11.2
Haematopoietic and lymphoid	BL70	10.9
Haematopoietic and lymphoid	BV173	10.4
Haematopoietic and lymphoid	CA46	9.5
Haematopoietic and lymphoid	CI1	10.8
Haematopoietic and lymphoid	CMK115	11.2
Haematopoietic and lymphoid	CMK86	12.1
Haematopoietic and lymphoid	CMK	11.6
Haematopoietic and lymphoid	CMLT1	10.8
Haematopoietic and lymphoid	COLO775	11.2
Haematopoietic and lymphoid	DAUDI	10.6
Haematopoietic and lymphoid	DB	10.9
Haematopoietic and lymphoid	DEL	10
Haematopoietic and lymphoid	DND41	11.5
Haematopoietic and lymphoid	DOHH2	10.9
Haematopoietic and lymphoid	EB1	9.6
Haematopoietic and lymphoid	EB2	9.8
Haematopoietic and lymphoid	EHEB	9.9
Haematopoietic and lymphoid	EJM	10.2
Haematopoietic and lymphoid	EM2	11
Haematopoietic and lymphoid	EOL1	11
Haematopoietic and lymphoid	F36P	11.1
Haematopoietic and lymphoid	GA10	11
Haematopoietic and lymphoid	GDM1	11
Haematopoietic and lymphoid	GRANTA519	10.7
Haematopoietic and lymphoid	HDLM2	9.9
Haematopoietic and lymphoid	HDMYZ	9.7
Haematopoietic and lymphoid	HEL9217	11.4
Haematopoietic and lymphoid	HEL	11.3
Haematopoietic and lymphoid	HH	10.9
Haematopoietic and lymphoid	HL60	11.4
Haematopoietic and lymphoid	HPBALL	11.3
Haematopoietic and lymphoid	HS604T	9.8
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	9.4
Haematopoietic and lymphoid	HS751T	8.9
Haematopoietic and lymphoid	HT	10.5
Haematopoietic and lymphoid	HTK	11.3
Haematopoietic and lymphoid	HUNS1	10.4
Haematopoietic and lymphoid	HUT102	9.6
Haematopoietic and lymphoid	HUT78	10.6
Haematopoietic and lymphoid	JEKO1	11
Haematopoietic and lymphoid	JK1	10.7
Haematopoietic and lymphoid	JM1	11.4
Haematopoietic and lymphoid	JURKAT	11.1
Haematopoietic and lymphoid	JURLMK1	10.8
Haematopoietic and lymphoid	JVM2	9.4
Haematopoietic and lymphoid	JVM3	10.1
Haematopoietic and lymphoid	K562	10.9
Haematopoietic and lymphoid	KARPAS299	8.8
Haematopoietic and lymphoid	KARPAS422	9.1
Haematopoietic and lymphoid	KARPAS620	11.2
Haematopoietic and lymphoid	KASUMI1	10.3
Haematopoietic and lymphoid	KASUMI2	11
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	10.8
Haematopoietic and lymphoid	KE37	11.2
Haematopoietic and lymphoid	KE97	10.1
Haematopoietic and lymphoid	KG1	10.2
Haematopoietic and lymphoid	KHM1B	9.6
Haematopoietic and lymphoid	KIJK	10.7
Haematopoietic and lymphoid	KMH2	11.3
Haematopoietic and lymphoid	KMM1	10.8
Haematopoietic and lymphoid	KMS11	10.5
Haematopoietic and lymphoid	KMS12BM	10.6
Haematopoietic and lymphoid	KMS18	10.5
Haematopoietic and lymphoid	KMS20	10.2
Haematopoietic and lymphoid	KMS21BM	9.9
Haematopoietic and lymphoid	KMS26	9.5
Haematopoietic and lymphoid	KMS27	9.8
Haematopoietic and lymphoid	KMS28BM	9.9
Haematopoietic and lymphoid	KMS34	9.9
Haematopoietic and lymphoid	KO52	10.3
Haematopoietic and lymphoid	KOPN8	11.6
Haematopoietic and lymphoid	KU812	11.6
Haematopoietic and lymphoid	KYO1	12.2
Haematopoietic and lymphoid	L1236	10.5
Haematopoietic and lymphoid	L363	9.6
Haematopoietic and lymphoid	L428	10.8
Haematopoietic and lymphoid	L540	10.2
Haematopoietic and lymphoid	LAMA84	10.5
Haematopoietic and lymphoid	LOUCY	10.2
Haematopoietic and lymphoid	LP1	9.1
Haematopoietic and lymphoid	M07E	11.8
Haematopoietic and lymphoid	MC116	10.7
Haematopoietic and lymphoid	ME1	11.4
Haematopoietic and lymphoid	MEC1	9.2
Haematopoietic and lymphoid	MEC2	10.9
Haematopoietic and lymphoid	MEG01	11.4
Haematopoietic and lymphoid	MHHCALL2	10.6
Haematopoietic and lymphoid	MHHCALL3	10.8
Haematopoietic and lymphoid	MHHCALL4	10.6
Haematopoietic and lymphoid	MINO	11.2
Haematopoietic and lymphoid	MJ	10.8
Haematopoietic and lymphoid	MM1S	10.3
Haematopoietic and lymphoid	MOLM13	11.5
Haematopoietic and lymphoid	MOLM16	12.1
Haematopoietic and lymphoid	MOLM6	11.3
Haematopoietic and lymphoid	MOLP2	10.3
Haematopoietic and lymphoid	MOLP8	9.2
Haematopoietic and lymphoid	MOLT13	11.2
Haematopoietic and lymphoid	MOLT16	10.5
Haematopoietic and lymphoid	MOLT4	11.1
Haematopoietic and lymphoid	MONOMAC1	10.5
Haematopoietic and lymphoid	MONOMAC6	10.7
Haematopoietic and lymphoid	MOTN1	10.3
Haematopoietic and lymphoid	MUTZ5	10.8
Haematopoietic and lymphoid	MV411	12
Haematopoietic and lymphoid	NALM19	10.9
Haematopoietic and lymphoid	NALM1	10.7
Haematopoietic and lymphoid	NALM6	10.8
Haematopoietic and lymphoid	NAMALWA	11.1
Haematopoietic and lymphoid	NB4	10.8
Haematopoietic and lymphoid	NCIH929	8.5
Haematopoietic and lymphoid	NCO2	11.1
Haematopoietic and lymphoid	NOMO1	10.4
Haematopoietic and lymphoid	NUDHL1	11.3
Haematopoietic and lymphoid	NUDUL1	10
Haematopoietic and lymphoid	OCIAML2	10.5
Haematopoietic and lymphoid	OCIAML3	11
Haematopoietic and lymphoid	OCIAML5	10.6
Haematopoietic and lymphoid	OCILY10	9.9
Haematopoietic and lymphoid	OCILY19	11.3
Haematopoietic and lymphoid	OCILY3	10.4
Haematopoietic and lymphoid	OCIM1	11
Haematopoietic and lymphoid	OPM2	9.8
Haematopoietic and lymphoid	P12ICHIKAWA	11.2
Haematopoietic and lymphoid	P31FUJ	9.9
Haematopoietic and lymphoid	P3HR1	10.8
Haematopoietic and lymphoid	PCM6	9.6
Haematopoietic and lymphoid	PEER	10.8
Haematopoietic and lymphoid	PF382	11
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	10.8
Haematopoietic and lymphoid	RAJI	10.6
Haematopoietic and lymphoid	RCHACV	10.4
Haematopoietic and lymphoid	REC1	10.7
Haematopoietic and lymphoid	REH	10.8
Haematopoietic and lymphoid	RI1	12.2
Haematopoietic and lymphoid	RL	9.8
Haematopoietic and lymphoid	RPMI8226	10.5
Haematopoietic and lymphoid	RPMI8402	11
Haematopoietic and lymphoid	RS411	10.9
Haematopoietic and lymphoid	SEM	10.8
Haematopoietic and lymphoid	SET2	11.4
Haematopoietic and lymphoid	SIGM5	11
Haematopoietic and lymphoid	SKM1	9.6
Haematopoietic and lymphoid	SKMM2	10.7
Haematopoietic and lymphoid	SR786	10.1
Haematopoietic and lymphoid	ST486	10.4
Haematopoietic and lymphoid	SUDHL10	11
Haematopoietic and lymphoid	SUDHL1	10.2
Haematopoietic and lymphoid	SUDHL4	10.9
Haematopoietic and lymphoid	SUDHL5	11
Haematopoietic and lymphoid	SUDHL6	10.7
Haematopoietic and lymphoid	SUDHL8	10.6
Haematopoietic and lymphoid	SUPB15	10.5
Haematopoietic and lymphoid	SUPHD1	10.9
Haematopoietic and lymphoid	SUPM2	9.1
Haematopoietic and lymphoid	SUPT11	11
Haematopoietic and lymphoid	SUPT1	10.8
Haematopoietic and lymphoid	TALL1	11.4
Haematopoietic and lymphoid	TF1	11.7
Haematopoietic and lymphoid	THP1	10.2
Haematopoietic and lymphoid	TO175T	9.8
Haematopoietic and lymphoid	TOLEDO	10.4
Haematopoietic and lymphoid	U266B1	10.3
Haematopoietic and lymphoid	U937	10.5
Haematopoietic and lymphoid	UT7	11
Haematopoietic and lymphoid	WSUDLCL2	10.1
Kidney	769P	10.4
Kidney	786O	10.3
Kidney	A498	11
Kidney	A704	8.4
Kidney	ACHN	9.8
Kidney	BFTC909	10.4
Kidney	CAKI1	9.3
Kidney	CAKI2	10.9
Kidney	CAL54	9.8
Kidney	KMRC1	9.9
Kidney	KMRC20	9.8
Kidney	KMRC2	10.7
Kidney	KMRC3	9.3
Kidney	OSRC2	10.5
Kidney	RCC10RGB	10.1
Kidney	SNU1272	10
Kidney	SNU349	10.5
Kidney	TUHR10TKB	10.4
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	9.5
Kidney	VMRCRCW	9.4
Kidney	VMRCRCZ	10.3
Large intestine	C2BBE1	11
Large intestine	CCK81	10.4
Large intestine	CL11	10.7
Large intestine	CL14	10.7
Large intestine	CL34	10.2
Large intestine	CL40	11
Large intestine	COLO205	9.6
Large intestine	COLO320	10.7
Large intestine	COLO678	9.8
Large intestine	CW2	10.9
Large intestine	DLD1	10.5
Large intestine	GP2D	10.1
Large intestine	HCC56	10.3
Large intestine	HCT116	11.4
Large intestine	HCT15	10.7
Large intestine	HS675T	9.3
Large intestine	HS698T	9.9
Large intestine	HT115	10.9
Large intestine	HT29	11.4
Large intestine	HT55	10
Large intestine	KM12	10
Large intestine	LOVO	10.4
Large intestine	LS1034	10.6
Large intestine	LS123	11
Large intestine	LS180	10.2
Large intestine	LS411N	10.3
Large intestine	LS513	9.6
Large intestine	MDST8	10.3
Large intestine	NCIH508	10
Large intestine	NCIH716	9.6
Large intestine	NCIH747	10.2
Large intestine	OUMS23	10.3
Large intestine	RCM1	9.5
Large intestine	RKO	10
Large intestine	SKCO1	9.9
Large intestine	SNU1040	10.6
Large intestine	SNU1197	10.1
Large intestine	SNU175	10.4
Large intestine	SNU283	10.5
Large intestine	SNU407	10.6
Large intestine	SNU503	10.8
Large intestine	SNU61	10.1
Large intestine	SNU81	11
Large intestine	SNUC1	10.3
Large intestine	SNUC2A	9.1
Large intestine	SNUC4	10.6
Large intestine	SNUC5	10.2
Large intestine	SW1116	10.2
Large intestine	SW1417	11
Large intestine	SW1463	10.2
Large intestine	SW403	10
Large intestine	SW480	10.4
Large intestine	SW48	10.6
Large intestine	SW620	10.8
Large intestine	SW837	9.8
Large intestine	SW948	9.7
Large intestine	T84	11.4
Liver	ALEXANDERCELLS	10.3
Liver	C3A	9.8
Liver	HEP3B217	10.3
Liver	HEPG2	10.4
Liver	HLE	10.3
Liver	HLF	10.7
Liver	HUH1	10.8
Liver	HUH6	11.8
Liver	HUH7	10.5
Liver	JHH1	11.1
Liver	JHH2	11
Liver	JHH4	11.1
Liver	JHH5	11.3
Liver	JHH6	9.2
Liver	JHH7	10.3
Liver	LI7	11.3
Liver	PLCPRF5	10.6
Liver	SKHEP1	9.9
Liver	SNU182	10.8
Liver	SNU387	10
Liver	SNU398	11
Liver	SNU423	10.2
Liver	SNU449	10.3
Liver	SNU475	10.3
Liver	SNU761	10.5
Liver	SNU878	10.9
Liver	SNU886	11.8
Lung	A549	11
Lung	ABC1	10.8
Lung	BEN	10.1
Lung	CAL12T	9.9
Lung	CALU1	10.1
Lung	CALU3	10.8
Lung	CALU6	10.8
Lung	CHAGOK1	10
Lung	COLO668	9.8
Lung	COLO699	10.2
Lung	CORL105	10.6
Lung	CORL23	10.8
Lung	CORL24	9.8
Lung	CORL279	11.4
Lung	CORL311	10.7
Lung	CORL47	10.2
Lung	CORL51	9.8
Lung	CORL88	10.2
Lung	CORL95	9.9
Lung	CPCN	10.5
Lung	DMS114	10.5
Lung	DMS153	10
Lung	DMS273	10.6
Lung	DMS454	9.5
Lung	DMS53	10.4
Lung	DMS79	10.2
Lung	DV90	10
Lung	EBC1	10.4
Lung	EPLC272H	10.9
Lung	HARA	11.2
Lung	HCC1171	10.3
Lung	HCC1195	9.6
Lung	HCC15	10.3
Lung	HCC2279	10
Lung	HCC2935	10.1
Lung	HCC33	10.8
Lung	HCC366	10.2
Lung	HCC4006	11
Lung	HCC44	10.6
Lung	HCC78	10.2
Lung	HCC827	10.9
Lung	HCC95	9.6
Lung	HLC1	10.1
Lung	HLFA	9.9
Lung	HS229T	9.8
Lung	HS618T	9.7
Lung	IALM	10.8
Lung	KNS62	10.1
Lung	LC1F	10.5
Lung	LC1SQSF	9.2
Lung	LCLC103H	9.9
Lung	LCLC97TM1	10.1
Lung	LK2	10.7
Lung	LOUNH91	10.1
Lung	LU65	10.5
Lung	LU99	10.6
Lung	LUDLU1	10.2
Lung	LXF289	9.9
Lung	MORCPR	10.5
Lung	NCIH1048	10.3
Lung	NCIH1092	9
Lung	NCIH1105	9.5
Lung	NCIH1155	10.3
Lung	NCIH1184	10.3
Lung	NCIH1299	11.2
Lung	NCIH1339	10.6
Lung	NCIH1341	10.3
Lung	NCIH1355	10.7
Lung	NCIH1373	9.8
Lung	NCIH1385	10.6
Lung	NCIH1395	10.3
Lung	NCIH1435	10.9
Lung	NCIH1436	10.3
Lung	NCIH1437	10.4
Lung	NCIH146	11.3
Lung	NCIH1563	9.6
Lung	NCIH1568	10.4
Lung	NCIH1573	9.3
Lung	NCIH1581	10.6
Lung	NCIH1618	10.5
Lung	NCIH1623	11.1
Lung	NCIH1648	9.9
Lung	NCIH1650	11.3
Lung	NCIH1651	10
Lung	NCIH1666	10.3
Lung	NCIH1693	9.5
Lung	NCIH1694	10.3
Lung	NCIH1703	10.1
Lung	NCIH1734	10.1
Lung	NCIH1755	10.7
Lung	NCIH1781	9.6
Lung	NCIH1792	10.8
Lung	NCIH1793	10.4
Lung	NCIH1836	10.5
Lung	NCIH1838	9.5
Lung	NCIH1869	10.5
Lung	NCIH1876	9.5
Lung	NCIH1915	9.7
Lung	NCIH1930	11
Lung	NCIH1944	10.7
Lung	NCIH1963	10.3
Lung	NCIH196	9.8
Lung	NCIH1975	11.5
Lung	NCIH2009	10.1
Lung	NCIH2023	10.4
Lung	NCIH2029	10.2
Lung	NCIH2030	10.2
Lung	NCIH2066	8.8
Lung	NCIH2081	9.7
Lung	NCIH2085	10.5
Lung	NCIH2087	9.7
Lung	NCIH209	10.8
Lung	NCIH2106	10.7
Lung	NCIH2110	9.3
Lung	NCIH211	9.9
Lung	NCIH2122	10.7
Lung	NCIH2126	10.7
Lung	NCIH2141	10.8
Lung	NCIH2170	12
Lung	NCIH2171	11.1
Lung	NCIH2172	10.3
Lung	NCIH2196	10.7
Lung	NCIH2227	12
Lung	NCIH2228	9.6
Lung	NCIH226	10.6
Lung	NCIH2286	10
Lung	NCIH2291	9.7
Lung	NCIH2342	10.3
Lung	NCIH2347	10.1
Lung	NCIH23	10.7
Lung	NCIH2405	10.1
Lung	NCIH2444	10.7
Lung	NCIH292	11.1
Lung	NCIH322	9.9
Lung	NCIH3255	11
Lung	NCIH358	10.5
Lung	NCIH441	9.8
Lung	NCIH446	11.3
Lung	NCIH460	10.6
Lung	NCIH510	10.1
Lung	NCIH520	10.4
Lung	NCIH522	10
Lung	NCIH524	10.8
Lung	NCIH526	11.4
Lung	NCIH596	9.5
Lung	NCIH647	10.5
Lung	NCIH650	10
Lung	NCIH661	10.1
Lung	NCIH69	10.7
Lung	NCIH727	10.9
Lung	NCIH810	10.5
Lung	NCIH82	11
Lung	NCIH838	10.4
Lung	NCIH841	10.6
Lung	NCIH854	10.4
Lung	NCIH889	10.8
Lung	PC14	10.1
Lung	RERFLCAD1	9.6
Lung	RERFLCAD2	10.1
Lung	RERFLCAI	10.3
Lung	RERFLCKJ	10.1
Lung	RERFLCMS	10
Lung	RERFLCSQ1	10.4
Lung	SBC5	10.2
Lung	SCLC21H	10.8
Lung	SHP77	10.5
Lung	SKLU1	10.5
Lung	SKMES1	9.9
Lung	SQ1	10.6
Lung	SW1271	10.3
Lung	SW1573	9.9
Lung	SW900	10.9
Lung	VMRCLCD	11.1
Lung	VMRCLCP	11.3
Oesophagus	COLO680N	9.6
Oesophagus	ECGI10	10.4
Oesophagus	KYSE140	10.4
Oesophagus	KYSE150	10.5
Oesophagus	KYSE180	10.8
Oesophagus	KYSE270	10.5
Oesophagus	KYSE30	10.5
Oesophagus	KYSE410	11.5
Oesophagus	KYSE450	9.9
Oesophagus	KYSE510	10.4
Oesophagus	KYSE520	10.6
Oesophagus	KYSE70	10.3
Oesophagus	OE19	11.1
Oesophagus	OE33	9.3
Oesophagus	TE10	10.9
Oesophagus	TE11	10.2
Oesophagus	TE14	10.3
Oesophagus	TE15	9.8
Oesophagus	TE1	10.1
Oesophagus	TE4	10.4
Oesophagus	TE5	9.3
Oesophagus	TE6	11.1
Oesophagus	TE8	10.4
Oesophagus	TE9	10.5
Oesophagus	TT	9.1
Ovary	59M	11.1
Ovary	A2780	10.8
Ovary	CAOV3	11
Ovary	CAOV4	10.5
Ovary	COLO704	11.2
Ovary	COV318	11.1
Ovary	COV362	10
Ovary	COV434	9.7
Ovary	COV504	10.6
Ovary	COV644	9.9
Ovary	EFO21	10.1
Ovary	EFO27	10.1
Ovary	ES2	10.3
Ovary	FUOV1	11.4
Ovary	HEYA8	10.4
Ovary	HS571T	9.3
Ovary	IGROV1	10.9
Ovary	JHOC5	10.6
Ovary	JHOM1	10.2
Ovary	JHOM2B	10.1
Ovary	JHOS2	9.4
Ovary	JHOS4	9.9
Ovary	KURAMOCHI	10.7
Ovary	MCAS	10.3
Ovary	NIHOVCAR3	10.5
Ovary	OAW28	9.6
Ovary	OAW42	10.6
Ovary	OC314	10.1
Ovary	OC316	10.2
Ovary	ONCODG1	10.1
Ovary	OV56	9.8
Ovary	OV7	9.8
Ovary	OV90	11.5
Ovary	OVCAR4	11.6
Ovary	OVCAR8	9.5
Ovary	OVISE	10.5
Ovary	OVK18	10.4
Ovary	OVKATE	9.3
Ovary	OVMANA	9.9
Ovary	OVSAHO	9.9
Ovary	OVTOKO	10.2
Ovary	RMGI	11.1
Ovary	RMUGS	11.1
Ovary	SKOV3	10.2
Ovary	SNU119	9.4
Ovary	SNU840	10.9
Ovary	SNU8	10.7
Ovary	TOV112D	10.9
Ovary	TOV21G	10.5
Ovary	TYKNU	9.9
Pancreas	ASPC1	8.8
Pancreas	BXPC3	11.4
Pancreas	CAPAN1	10.9
Pancreas	CAPAN2	10.3
Pancreas	CFPAC1	10.4
Pancreas	DANG	10.4
Pancreas	HPAC	10.8
Pancreas	HPAFII	9.9
Pancreas	HS766T	9.6
Pancreas	HUPT3	10.5
Pancreas	HUPT4	10.3
Pancreas	KCIMOH1	10.3
Pancreas	KLM1	11.9
Pancreas	KP2	10.4
Pancreas	KP3	9.1
Pancreas	KP4	9.8
Pancreas	L33	10.7
Pancreas	MIAPACA2	11.4
Pancreas	PANC0203	10.7
Pancreas	PANC0213	9.8
Pancreas	PANC0327	10.6
Pancreas	PANC0403	9.6
Pancreas	PANC0504	10.2
Pancreas	PANC0813	10.1
Pancreas	PANC1005	10.5
Pancreas	PANC1	10.5
Pancreas	PATU8902	10.3
Pancreas	PATU8988S	10.1
Pancreas	PATU8988T	10.7
Pancreas	PK1	10.5
Pancreas	PK45H	9.5
Pancreas	PK59	11.1
Pancreas	PL45	10.2
Pancreas	PSN1	10.7
Pancreas	QGP1	9.7
Pancreas	SNU213	9.8
Pancreas	SNU324	10.4
Pancreas	SNU410	10
Pancreas	SU8686	9.3
Pancreas	SUIT2	8.7
Pancreas	SW1990	10.4
Pancreas	T3M4	10.7
Pancreas	TCCPAN2	10.7
Pancreas	YAPC	9.7
Pleura	ACCMESO1	9.6
Pleura	DM3	10
Pleura	ISTMES1	10.3
Pleura	ISTMES2	9.9
Pleura	JL1	10.3
Pleura	MPP89	10.2
Pleura	MSTO211H	10
Pleura	NCIH2052	10.5
Pleura	NCIH2452	9.2
Pleura	NCIH28	10.2
Prostate	22RV1	10.7
Prostate	DU145	9.6
Prostate	LNCAPCLONEFGC	9.9
Prostate	MDAPCA2B	10.1
Prostate	NCIH660	10.8
Prostate	PC3	11
Prostate	VCAP	10.6
Salivary gland	A253	9.5
Salivary gland	YD15	10.3
Skin	A101D	10.5
Skin	A2058	11.3
Skin	A375	11.6
Skin	C32	9.9
Skin	CHL1	9.9
Skin	CJM	9.9
Skin	COLO679	10.5
Skin	COLO741	9.2
Skin	COLO783	9.7
Skin	COLO792	9.2
Skin	COLO800	10.4
Skin	COLO818	9.6
Skin	COLO829	10.7
Skin	COLO849	11.8
Skin	G361	10.5
Skin	GRM	11.4
Skin	HMCB	10.7
Skin	HS294T	11.1
Skin	HS600T	9.3
Skin	HS688AT	9
Skin	HS695T	10.5
Skin	HS839T	9.2
Skin	HS852T	10.1
Skin	HS895T	9.1
Skin	HS934T	9.8
Skin	HS936T	9.6
Skin	HS939T	10
Skin	HS940T	9.7
Skin	HS944T	11.3
Skin	HT144	10.4
Skin	IGR1	9.8
Skin	IGR37	11.2
Skin	IGR39	10.5
Skin	IPC298	10.3
Skin	K029AX	10.2
Skin	LOXIMVI	10.8
Skin	MALME3M	9.9
Skin	MDAMB435S	9.2
Skin	MELHO	10.5
Skin	MELJUSO	10.6
Skin	MEWO	9.9
Skin	RPMI7951	9.9
Skin	RVH421	9.1
Skin	SH4	9.9
Skin	SKMEL1	9.7
Skin	SKMEL24	10.2
Skin	SKMEL28	10.4
Skin	SKMEL2	10.5
Skin	SKMEL30	9.4
Skin	SKMEL31	9.8
Skin	SKMEL3	10.1
Skin	SKMEL5	10.6
Skin	UACC257	11
Skin	UACC62	11.4
Skin	WM115	9.9
Skin	WM1799	9.6
Skin	WM2664	10.9
Skin	WM793	10.2
Skin	WM88	9.4
Skin	WM983B	9
Small intestine	HUTU80	10.5
Soft tissue	A204	10.4
Soft tissue	G401	11.1
Soft tissue	G402	10.7
Soft tissue	GCT	10.5
Soft tissue	HS729	8.9
Soft tissue	HT1080	10.9
Soft tissue	KYM1	9.9
Soft tissue	MESSA	10.8
Soft tissue	RD	10.4
Soft tissue	RH30	11.7
Soft tissue	RH41	11.3
Soft tissue	RKN	9.7
Soft tissue	S117	10.4
Soft tissue	SJRH30	11.1
Soft tissue	SKLMS1	10
Soft tissue	SKUT1	10.4
Soft tissue	TE125T	9.1
Soft tissue	TE159T	9.5
Soft tissue	TE441T	10.6
Soft tissue	TE617T	10.8
Stomach	2313287	10
Stomach	AGS	11.2
Stomach	AZ521	11.1
Stomach	ECC10	10.9
Stomach	ECC12	11.5
Stomach	FU97	11
Stomach	GCIY	11
Stomach	GSS	10.7
Stomach	GSU	10.4
Stomach	HGC27	10.2
Stomach	HS746T	9.5
Stomach	HUG1N	12
Stomach	IM95	10.9
Stomach	KATOIII	10.7
Stomach	KE39	10.3
Stomach	LMSU	10.4
Stomach	MKN1	9.2
Stomach	MKN45	10.8
Stomach	MKN74	9.5
Stomach	MKN7	9.5
Stomach	NCCSTCK140	11.4
Stomach	NCIN87	11
Stomach	NUGC2	10.2
Stomach	NUGC3	10.9
Stomach	NUGC4	9.7
Stomach	OCUM1	10.4
Stomach	RERFGC1B	10.7
Stomach	SH10TC	10.3
Stomach	SNU16	10.7
Stomach	SNU1	9.6
Stomach	SNU216	10.4
Stomach	SNU520	10.6
Stomach	SNU5	10.5
Stomach	SNU601	11.8
Stomach	SNU620	10.7
Stomach	SNU668	11.4
Stomach	SNU719	11.2
Stomach	TGBC11TKB	10.4
Thyroid	8305C	10.9
Thyroid	8505C	10.5
Thyroid	BCPAP	10.7
Thyroid	BHT101	9.7
Thyroid	CAL62	10.6
Thyroid	CGTHW1	10.3
Thyroid	FTC133	10.3
Thyroid	FTC238	9.8
Thyroid	ML1	10
Thyroid	SW579	11
Thyroid	TT2609C02	10.7
Thyroid	TT	10.4
Upper aerodigestive tract	BHY	9.7
Upper aerodigestive tract	BICR16	10.1
Upper aerodigestive tract	BICR18	9.9
Upper aerodigestive tract	BICR22	9.7
Upper aerodigestive tract	BICR31	10.6
Upper aerodigestive tract	BICR56	9.1
Upper aerodigestive tract	BICR6	10.4
Upper aerodigestive tract	CAL27	10.3
Upper aerodigestive tract	CAL33	10.4
Upper aerodigestive tract	DETROIT562	9.7
Upper aerodigestive tract	FADU	9.5
Upper aerodigestive tract	HS840T	9.9
Upper aerodigestive tract	HSC2	9.8
Upper aerodigestive tract	HSC3	9.9
Upper aerodigestive tract	HSC4	9.6
Upper aerodigestive tract	PECAPJ15	9.6
Upper aerodigestive tract	PECAPJ34CLONEC12	9.8
Upper aerodigestive tract	PECAPJ41CLONED2	9.4
Upper aerodigestive tract	PECAPJ49	9.8
Upper aerodigestive tract	SCC15	10.1
Upper aerodigestive tract	SCC25	10.3
Upper aerodigestive tract	SCC4	10.8
Upper aerodigestive tract	SCC9	10.6
Upper aerodigestive tract	SNU1076	9.9
Upper aerodigestive tract	SNU1214	10.4
Upper aerodigestive tract	SNU46	10.8
Upper aerodigestive tract	SNU899	10
Upper aerodigestive tract	YD10B	9.8
Upper aerodigestive tract	YD38	10.4
Upper aerodigestive tract	YD8	10
Urinary tract	5637	10.5
Urinary tract	639V	11.4
Urinary tract	647V	11.2
Urinary tract	BC3C	10.3
Urinary tract	BFTC905	10.5
Urinary tract	CAL29	10.5
Urinary tract	HS172T	8.9
Urinary tract	HT1197	9.8
Urinary tract	HT1376	9.6
Urinary tract	J82	9.7
Urinary tract	JMSU1	10.7
Urinary tract	KMBC2	9.9
Urinary tract	KU1919	10.4
Urinary tract	RT11284	9.8
Urinary tract	RT112	10.9
Urinary tract	RT4	11.1
Urinary tract	SCABER	10.4
Urinary tract	SW1710	10.3
Urinary tract	SW780	10.8
Urinary tract	T24	10.5
Urinary tract	TCCSUP	10.3
Urinary tract	UMUC1	10.9
Urinary tract	UMUC3	10.5
Urinary tract	VMCUB1	10.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	63.6
Adrenal gland	76.8
Appendix	126.5
Bone marrow	103
Breast	64.8
Cerebral cortex	79
Cervix, uterine	91.1
Colon	63.4
Duodenum	75.4
Endometrium	151.4
Epididymis	41.8
Esophagus	90.7
Fallopian tube	143.3
Gallbladder	92.5
Heart muscle	39.5
Kidney	45
Liver	20.9
Lung	87.6
Lymph node	132.4
Ovary	215.6
Pancreas	22.4
Parathyroid gland	123.9
Placenta	121.9
Prostate	95.7
Rectum	54.3
Salivary gland	38.7
Seminal vesicle	111.7
Skeletal muscle	32.5
Skin	132.9
Small intestine	77.9
Smooth muscle	109.7
Spleen	104.5
Stomach	60
Testis	202.4
Thyroid gland	119.6
Tonsil	83.6
Urinary bladder	84.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27412325	overexpression	Breast Carcinoma	We find that TRIM28 is highly expressed in both cancer cell lines and advanced breast cancer tissues, and the levels of TRIM28 and TWIST1 are positively correlated with the aggressiveness of breast carcinomas.
26476730	overexpression	Glioma	First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glioma controls (n = 6).
23425061	overexpression	Colorectal Carcinoma	Strong epithelial TRIM28 expression was found in 42% of colorectal cancer tissues.
23060449	aberrant expression	Lung Carcinoma; Breast Carcinoma	Although Trim28 mRNA is found in many studies to be up-regulated in both lung and breast cancer tissues relative to normal adjacent tissue, we found that within a panel of early-stage lung adenocarcinomas high levels of Trim28 protein correlate with better overall survival.
22959342	overexpression	Non-Small Cell Lung Carcinoma	In this study, we demonstrated the expression of TRIM28 gene was significantly higher in cancerous tissues than in noncancerous tissues (P < 0.001).
25941598	overexpression	Cutaneous T-Cell Non-Hodgkin Lymphoma	Furthermore, select ESC genes (OCT4, EED, TCF3, THAP11, CHD7, TIP60, TRIM28) are preferentially expressed in CTCL samples when compared to benign skin biopsies.
28454449	Overexpression	Breast Carcinoma	In the present study, the expression of TRIM28 was identified to be significantly higher in cancerous compared with healthy tissue samples. Furthermore, it was demonstrated that TRIM28 expression was significantly correlated with several clinicopathological characteristics of patients with BC, such as p53 mutation, tumor recurrence and Elston grade of the tumor.
27845900	Overexpression	Breast Carcinoma	High level of TRIM28 is associated with triple-negative subtype of breast cancer (TNBC), which shows higher aggressiveness and lower survival rates.

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.585	1.86e-38	16.8	46.5	36.6	Gain
BRCA	Breast invasive carcinoma	1075	0.479	1.26e-62	16.7	59.3	23.9	Neutral
CESC	Cervical and endocervical cancers	292	0.626	3.61e-33	9.9	57.9	32.2	Neutral
COAD	Colon adenocarcinoma	449	0.392	6.3e-18	9.8	70.4	19.8	Neutral
ESCA	Esophageal carcinoma	183	0.555	3.81e-16	29	42.1	29	Neutral
GBM	Glioblastoma multiforme	147	0.535	2.92e-12	15.6	54.4	29.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.572	4.95e-46	18.5	63.2	18.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.282	4.97e-11	1.3	88.4	10.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.252	1.51e-05	6.2	91.7	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.044	0.573	3	93.4	3.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.469	1.8e-29	52.2	43.1	4.7	Loss
LIHC	Liver hepatocellular carcinoma	364	0.483	1.2e-22	9.1	68.4	22.5	Neutral
LUAD	Lung adenocarcinoma	512	0.477	1.77e-30	35	48.8	16.2	Loss
LUSC	Lung squamous cell carcinoma	498	0.596	2.89e-49	25.9	39.4	34.7	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.717	1.37e-48	46	30.3	23.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.357	1.09e-06	9.6	70.1	20.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.422	2.3e-08	6.8	85.2	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.122	0.00691	4.5	92.1	3.5	Neutral
READ	Rectum adenocarcinoma	164	0.464	4.04e-10	14.6	66.5	18.9	Neutral
SARC	Sarcoma	255	0.515	1.07e-18	40.4	43.1	16.5	Loss
SKCM	Skin Cutaneous Melanoma	367	0.367	3.6e-13	22.3	61.9	15.8	Neutral
STAD	Stomach adenocarcinoma	413	0.567	1.73e-36	15.5	58.8	25.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.27	0.000819	37.3	44.7	18	Loss
THCA	Thyroid carcinoma	497	0.254	9.21e-09	0.2	97.8	2	Neutral
THYM	Thymoma	119	-0.137	0.136	2.5	95	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.377	1.35e-19	12.3	75.4	12.3	Neutral

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.271	1.53e-08	17	408	0	0.67	NS/NA
BRCA	Breast invasive carcinoma	-0.07	0.0391	83	785	0.001	0.0421	NS/NA
CESC	Cervical and endocervical cancers	-0.328	4.52e-09	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.124	0.0271	19	297	0.001	0.0784	NS/NA
ESCA	Esophageal carcinoma	-0.19	0.00792	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.101	0.422	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.115	0.00753	20	522	0	0.541	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.131	0.0149	24	319	-0.006	0.18	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.083	0.151	23	275	0.002	0.611	NS/NA
LAML	Acute Myeloid Leukemia	-0.173	0.0241	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.201	3.17e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.165	0.00078	41	373	0	0.301	NS/NA
LUAD	Lung adenocarcinoma	-0.048	0.297	21	456	0.001	0.63	NS/NA
LUSC	Lung squamous cell carcinoma	-0.241	2.19e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.28	0.000134	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.116	0.114	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.196	5.1e-06	35	498	0.005	0.416	NS/NA
READ	Rectum adenocarcinoma	-0.185	0.0638	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.285	2.97e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.13	0.00468	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.274	9.13e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.202	0.0114	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.065	0.122	50	509	0	0.988	NS/NA
THYM	Thymoma	-0.088	0.332	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.084	0.0709	34	431	0	0.801	NS/NA

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.7	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00259	Significant	23000897
COAD	Colon adenocarcinoma	149	0.281	NS	22810696
GBM	Glioblastoma multiforme	157	5.18e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.111	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.119	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.07e-18	Significant	26824661
LUAD	Lung adenocarcinoma	230	3.12e-06	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0102	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00168	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00709	Significant	26544944
READ	Rectum adenocarcinoma	67	0.469	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.472	NS	26091043
STAD	Stomach adenocarcinoma	277	2.98e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.891	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00334	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.44	0.0736	NS
BRCA	Breast invasive carcinoma	1079	0.879	0.572	NS
CESC	Cervical and endocervical cancers	291	0.802	0.498	NS
COAD	Colon adenocarcinoma	439	0.972	0.919	NS
ESCA	Esophageal carcinoma	184	1.164	0.653	NS
GBM	Glioblastoma multiforme	158	0.911	0.716	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.032	0.865	NS
KIRC	Kidney renal clear cell carcinoma	531	1.431	0.0905	NS
KIRP	Kidney renal papillary cell carcinoma	287	2.142	0.0473	Shorter
LAML	Acute Myeloid Leukemia	149	1.187	0.583	NS
LGG	Brain Lower Grade Glioma	511	1.648	0.0601	NS
LIHC	Liver hepatocellular carcinoma	365	2.069	0.00334	Shorter
LUAD	Lung adenocarcinoma	502	1.79	0.00566	Shorter
LUSC	Lung squamous cell carcinoma	494	0.976	0.901	NS
OV	Ovarian serous cystadenocarcinoma	303	1.087	0.694	NS
PAAD	Pancreatic adenocarcinoma	177	0.587	0.0676	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.154	NS
PRAD	Prostate adenocarcinoma	497	476799714.052	0.262	NS
READ	Rectum adenocarcinoma	159	0.879	0.839	NS
SARC	Sarcoma	259	1.447	0.183	NS
SKCM	Skin Cutaneous Melanoma	459	1.89	0.00131	Shorter
STAD	Stomach adenocarcinoma	388	1.06	0.783	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.351	NS
THCA	Thyroid carcinoma	500	1.028	0.967	NS
THYM	Thymoma	119	0	0.0444	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.942	0.837	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.038	0.446	NS
BRCA	Breast invasive carcinoma	1071	0.039	0.199	NS
CESC	Cervical and endocervical cancers	167	0.014	0.854	NS
COAD	Colon adenocarcinoma	445	-0.03	0.531	NS
ESCA	Esophageal carcinoma	162	-0.06	0.45	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.011	0.814	NS
KIRC	Kidney renal clear cell carcinoma	531	0.052	0.235	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.268	1.2e-05	Higher
LIHC	Liver hepatocellular carcinoma	347	0.163	0.00231	Higher
LUAD	Lung adenocarcinoma	507	0.091	0.0415	Higher
LUSC	Lung squamous cell carcinoma	497	0.07	0.121	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.035	0.539	NS
PAAD	Pancreatic adenocarcinoma	176	-0.047	0.536	NS
READ	Rectum adenocarcinoma	156	-0.099	0.22	NS
SKCM	Skin Cutaneous Melanoma	410	-0.044	0.378	NS
STAD	Stomach adenocarcinoma	392	-0.046	0.363	NS
TGCT	Testicular Germ Cell Tumors	81	-0.088	0.434	NS
THCA	Thyroid carcinoma	499	0.058	0.2	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.005	0.915	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.184	0.0023	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.075	0.0936	NS
KIRC	Kidney renal clear cell carcinoma	525	0.053	0.23	NS
LGG	Brain Lower Grade Glioma	514	0.132	0.00277	Higher
LIHC	Liver hepatocellular carcinoma	366	0.223	1.67e-05	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.031	0.591	NS
PAAD	Pancreatic adenocarcinoma	176	0.018	0.815	NS
STAD	Stomach adenocarcinoma	406	-0.093	0.062	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.182	2.29e-05	Higher

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TRIM28.

Summary
Symbol	TRIM28
Name	tripartite motif containing 28
Aliases	TIF1B; TF1B; RNF96; PPP1R157; protein phosphatase 1, regulatory subunit 157; tripartite motif-containing 28; ......
Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27412325	Breast Carcinoma	downstream	TWIST1	positive regulation	Overexpression and depletion of TRIM28 up- and down-regulates the protein, but not the mRNA levels of TWIST1, respectively, suggesting that TRIM28 upregulates TWIST1 post-transcriptionally.
26476730	Glioma	partner	p21	negative correlation	Notably, TRIM28 expression was negatively correlated with p21 expression in patients with glioblastoma multiforme (GBM).
23425061	Colorectal Carcinoma	partner	p53	correlation	TRIM28 expression correlated significantly with p53 expression in matched cases (P=0.0168, Spearman rank test).