CR2Cancer

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF02259 FAT domain
PF00454 Phosphatidylinositol 3- and 4-kinase

Function

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor	Histone acetylation	#	#	14966270

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0016578 histone deubiquitination GO:0016579 protein deubiquitination GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0070646 protein modification by small protein removal GO:1904837 beta-catenin-TCF complex assembly
Molecular Function	-
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000125 PCAF complex GO:0000428 DNA-directed RNA polymerase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000812 Swr1 complex GO:0005667 transcription factor complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0030914 STAGA complex GO:0031248 protein acetyltransferase complex GO:0033276 transcription factor TFTC complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0070461 SAGA-type complex GO:0070603 SWI/SNF superfamily-type complex GO:0090575 RNA polymerase II transcription factor complex GO:0097346 INO80-type complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5688426: Deubiquitination R-HSA-201722: Formation of the beta-catenin R-HSA-3214847: HATs acetylate histones R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5689880: Ub-specific processing proteases

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-5688426: Deubiquitination
R-HSA-201722: Formation of the beta-catenin
R-HSA-3214847: HATs acetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5689880: Ub-specific processing proteases

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1623359	c.7040G>T	p.R2347L	Substitution - Missense	Liver
COSM2866845	c.9983C>T	p.A3328V	Substitution - Missense	Large_intestine
COSM485786	c.1353T>C	p.V451V	Substitution - coding silent	Kidney
COSM1623351	c.2217T>C	p.I739I	Substitution - coding silent	Liver
COSM5611032	c.1731C>A	p.P577P	Substitution - coding silent	Skin
COSM5589224	c.8844C>T	p.D2948D	Substitution - coding silent	Skin
COSM1623349	c.1536A>C	p.P512P	Substitution - coding silent	Liver
COSM3412551	c.11236C>T	p.R3746W	Substitution - Missense	Liver
COSM12943	c.8015C>T	p.P2672L	Substitution - Missense	Lung
COSM1093581	c.2282G>T	p.R761L	Substitution - Missense	Endometrium
COSM748353	c.1309G>C	p.E437Q	Substitution - Missense	Lung
COSM129932	c.80C>T	p.A27V	Substitution - Missense	Upper_aerodigestive_tract
COSM4491647	c.3843C>T	p.P1281P	Substitution - coding silent	Skin
COSM1568782	c.5732C>T	p.P1911L	Substitution - Missense	Large_intestine
COSM3642749	c.1577C>T	p.P526L	Substitution - Missense	Skin
COSM3642828	c.9125C>T	p.P3042L	Substitution - Missense	Skin
COSM1453178	c.4796_4797insG	p.A1602fs*35	Insertion - Frameshift	Large_intestine
COSM4793948	c.2447G>A	p.R816Q	Substitution - Missense	Liver
COSM3642808	c.6984C>T	p.F2328F	Substitution - coding silent	Skin
COSM21330	c.2544G>T	p.T848T	Substitution - coding silent	Ovary
COSM1623347	c.1530G>C	p.P510P	Substitution - coding silent	Liver
COSM382495	c.5569G>T	p.V1857L	Substitution - Missense	Lung
COSM3883738	c.5663A>G	p.H1888R	Substitution - Missense	Stomach
COSM453648	c.8595G>C	p.K2865N	Substitution - Missense	Breast
COSM5611064	c.3048G>A	p.K1016K	Substitution - coding silent	Skin
COSM1093636	c.5102G>A	p.R1701Q	Substitution - Missense	Endometrium
COSM1453180	c.4948C>T	p.R1650*	Substitution - Nonsense	Large_intestine
COSM238563	c.6023C>T	p.P2008L	Substitution - Missense	Prostate
COSM3883730	c.4766A>T	p.N1589I	Substitution - Missense	Stomach
COSM1093654	c.6819C>T	p.S2273S	Substitution - coding silent	Endometrium
COSM307153	c.8949G>T	p.A2983A	Substitution - coding silent	Central_nervous_system
COSM4975591	c.5001G>A	p.M1667I	Substitution - Missense	Oesophagus
COSM4889808	c.3141C>A	p.R1047R	Substitution - coding silent	Upper_aerodigestive_tract
COSM5008459	c.9225T>G	p.V3075V	Substitution - coding silent	Large_intestine
COSM20429	c.9809G>A	p.R3270H	Substitution - Missense	Large_intestine
COSM1673340	c.10900A>G	p.T3634A	Substitution - Missense	Large_intestine
COSM3883732	c.4958G>T	p.W1653L	Substitution - Missense	Stomach
COSM5484946	c.5523C>T	p.R1841R	Substitution - coding silent	Large_intestine
COSM5009476	c.8896G>A	p.D2966N	Substitution - Missense	Large_intestine
COSM222135	c.11153C>T	p.P3718L	Substitution - Missense	Skin
COSM5749411	c.10880T>G	p.L3627R	Substitution - Missense	Genital_tract
COSM1243704	c.7891G>A	p.A2631T	Substitution - Missense	Oesophagus
COSM5408362	c.6769C>T	p.L2257F	Substitution - Missense	Skin
COSM3762912	c.7257G>A	p.A2419A	Substitution - coding silent	Large_intestine
COSM3748936	c.356G>A	p.R119H	Substitution - Missense	Stomach
COSM4640818	c.927G>A	p.M309I	Substitution - Missense	Large_intestine
COSM3833579	c.4435G>A	p.V1479M	Substitution - Missense	Breast
COSM5763147	c.4713+1G>A	p.?	Unknown	Large_intestine
COSM3642782	c.4949G>T	p.R1650L	Substitution - Missense	Skin
COSM1664718	c.3734T>A	p.L1245*	Substitution - Nonsense	Kidney
COSM1453235	c.11154G>A	p.P3718P	Substitution - coding silent	Stomach
COSM1453158	c.3406C>T	p.P1136S	Substitution - Missense	Skin
COSM3883756	c.7789G>A	p.V2597I	Substitution - Missense	Stomach
COSM3982201	c.9222A>C	p.E3074D	Substitution - Missense	Oesophagus
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM5565773	c.10787G>A	p.R3596Q	Substitution - Missense	Prostate
COSM1453235	c.11154G>A	p.P3718P	Substitution - coding silent	Large_intestine
COSM1093615	c.4103C>T	p.A1368V	Substitution - Missense	Stomach
COSM1673336	c.2087G>A	p.R696H	Substitution - Missense	Central_nervous_system
COSM248028	c.10383G>A	p.T3461T	Substitution - coding silent	Skin
COSM5759168	c.7170G>A	p.P2390P	Substitution - coding silent	Bone
COSM3929289	c.1961C>T	p.T654M	Substitution - Missense	Central_nervous_system
COSM5634965	c.9112A>G	p.I3038V	Substitution - Missense	Oesophagus
COSM1453206	c.7992C>T	p.C2664C	Substitution - coding silent	Large_intestine
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM4805249	c.4780A>G	p.I1594V	Substitution - Missense	Liver
COSM235525	c.7365C>T	p.R2455R	Substitution - coding silent	Skin
COSM3770310	c.4051A>T	p.T1351S	Substitution - Missense	Soft_tissue
COSM316221	c.8894A>G	p.D2965G	Substitution - Missense	Lung
COSM398370	c.292C>G	p.H98D	Substitution - Missense	Lung
COSM199169	c.11397C>T	p.F3799F	Substitution - coding silent	Endometrium
COSM1330438	c.630A>C	p.R210R	Substitution - coding silent	Ovary
COSM748355	c.1195G>A	p.V399I	Substitution - Missense	Large_intestine
COSM3642751	c.1581C>T	p.F527F	Substitution - coding silent	Skin
COSM5611036	c.8922C>T	p.F2974F	Substitution - coding silent	Skin
COSM5757102	c.5969A>G	p.D1990G	Substitution - Missense	Large_intestine
COSM4506303	c.7113C>T	p.L2371L	Substitution - coding silent	Skin
COSM1453233	c.11044C>T	p.R3682*	Substitution - Nonsense	Large_intestine
COSM1176879	c.3251C>T	p.S1084L	Substitution - Missense	Breast
COSM748329	c.7668C>A	p.P2556P	Substitution - coding silent	Prostate
COSM1093605	c.3646C>T	p.R1216W	Substitution - Missense	Endometrium
COSM1093645	c.5629G>A	p.A1877T	Substitution - Missense	Endometrium
COSM3883698	c.1109C>T	p.T370I	Substitution - Missense	Stomach
COSM2866625	c.4870G>T	p.A1624S	Substitution - Missense	Upper_aerodigestive_tract
COSM3883710	c.2632C>T	p.R878C	Substitution - Missense	Stomach
COSM5718374	c.5964C>T	p.A1988A	Substitution - coding silent	Skin
COSM748315	c.10866C>G	p.L3622L	Substitution - coding silent	Lung
COSM5802205	c.1862_1885del24	p.T622_K629delTVRMKEEK	Deletion - In frame	Breast
COSM1623351	c.2217T>C	p.I739I	Substitution - coding silent	Liver
COSM5460724	c.6428_6429insA	p.V2144fs*28	Insertion - Frameshift	Large_intestine
COSM4915543	c.5765A>T	p.Q1922L	Substitution - Missense	Liver
COSM4587651	c.6521C>T	p.P2174L	Substitution - Missense	Bone
COSM6012791	c.4306G>A	p.D1436N	Substitution - Missense	Skin
COSM748341	c.4252A>C	p.I1418L	Substitution - Missense	Lung
COSM1453166	c.4082C>T	p.S1361L	Substitution - Missense	Large_intestine
COSM5191684	c.5457G>A	p.T1819T	Substitution - coding silent	Skin
COSM5676921	c.2687G>T	p.G896V	Substitution - Missense	Soft_tissue
COSM1093728	c.11064G>A	p.A3688A	Substitution - coding silent	Endometrium
COSM4984034	c.7140G>A	p.K2380K	Substitution - coding silent	Oesophagus
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1093605	c.3646C>T	p.R1216W	Substitution - Missense	Stomach
COSM1230623	c.10195G>A	p.V3399I	Substitution - Missense	Large_intestine
COSM4149437	c.2485G>C	p.D829H	Substitution - Missense	Biliary_tract
COSM1698984	c.7846C>T	p.P2616S	Substitution - Missense	Skin
COSM2866847	c.10004delC	p.H3337fs*6	Deletion - Frameshift	Large_intestine
COSM3883726	c.4611A>G	p.R1537R	Substitution - coding silent	Stomach
COSM5901519	c.11152C>T	p.P3718S	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM2866806	c.9100C>T	p.R3034W	Substitution - Missense	Large_intestine
COSM4443079	c.8378C>A	p.P2793H	Substitution - Missense	Large_intestine
COSM4827226	c.11236C>A	p.R3746R	Substitution - coding silent	Cervix
COSM1453164	c.3930G>T	p.E1310D	Substitution - Missense	Large_intestine
COSM248902	c.2446C>T	p.R816W	Substitution - Missense	Large_intestine
COSM3703323	c.8616C>T	p.Y2872Y	Substitution - coding silent	Liver
COSM5886553	c.199C>T	p.P67S	Substitution - Missense	Skin
COSM1230633	c.10819G>A	p.D3607N	Substitution - Missense	Large_intestine
COSM3642792	c.6393C>T	p.F2131F	Substitution - coding silent	Skin
COSM21294	c.8738C>T	p.T2913M	Substitution - Missense	Large_intestine
COSM264227	c.8518C>T	p.R2840W	Substitution - Missense	Large_intestine
COSM20551	c.5117G>A	p.R1706H	Substitution - Missense	Stomach
COSM3431926	c.11007C>T	p.I3669I	Substitution - coding silent	Large_intestine
COSM3929291	c.4571C>T	p.T1524M	Substitution - Missense	Central_nervous_system
COSM4162523	c.9407A>C	p.N3136T	Substitution - Missense	Thyroid
COSM1623347	c.1530G>C	p.P510P	Substitution - coding silent	Liver
COSM1093627	c.4751A>G	p.D1584G	Substitution - Missense	Endometrium
COSM1686032	c.10290C>A	p.F3430L	Substitution - Missense	Skin
COSM4510999	c.8487C>G	p.I2829M	Substitution - Missense	Skin
COSM5413496	c.4782C>T	p.I1594I	Substitution - coding silent	Skin
COSM1673336	c.2087G>A	p.R696H	Substitution - Missense	Prostate
COSM4736779	c.6205A>G	p.K2069E	Substitution - Missense	Large_intestine
COSM5611022	c.6047C>T	p.S2016F	Substitution - Missense	Skin
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Skin
COSM1177676	c.5035G>A	p.A1679T	Substitution - Missense	Endometrium
COSM4983185	c.8467G>A	p.G2823S	Substitution - Missense	Oesophagus
COSM98971	c.355C>T	p.R119C	Substitution - Missense	Skin
COSM4851892	c.7012G>A	p.E2338K	Substitution - Missense	Cervix
COSM1453233	c.11044C>T	p.R3682*	Substitution - Nonsense	Skin
COSM4901146	c.100C>G	p.P34A	Substitution - Missense	Skin
COSM316225	c.7957G>T	p.A2653S	Substitution - Missense	Soft_tissue
COSM1673338	c.8980C>T	p.H2994Y	Substitution - Missense	Large_intestine
COSM5062698	c.1598A>G	p.K533R	Substitution - Missense	Stomach
COSM5611410	c.10764_10765CC>TT	p.R3589W	Substitution - Missense	Skin
COSM3883702	c.1841A>G	p.Y614C	Substitution - Missense	Stomach
COSM3431922	c.7039C>T	p.R2347W	Substitution - Missense	Large_intestine
COSM227767	c.9475C>T	p.R3159W	Substitution - Missense	Skin
COSM1645088	c.6953C>T	p.A2318V	Substitution - Missense	Salivary_gland
COSM118225	c.2322C>A	p.L774L	Substitution - coding silent	Ovary
COSM5586869	c.198C>T	p.I66I	Substitution - coding silent	Skin
COSM1664722	c.10020T>G	p.N3340K	Substitution - Missense	Kidney
COSM2866756	c.7664C>T	p.T2555M	Substitution - Missense	Large_intestine
COSM3768589	c.2642G>A	p.R881H	Substitution - Missense	Liver
COSM373284	c.4434G>T	p.V1478V	Substitution - coding silent	Lung
COSM5062706	c.8978A>G	p.Q2993R	Substitution - Missense	Stomach
COSM5611028	c.5116C>A	p.R1706S	Substitution - Missense	Skin
COSM3642759	c.2425C>T	p.L809L	Substitution - coding silent	Skin
COSM3431920	c.6945G>A	p.T2315T	Substitution - coding silent	Large_intestine
COSM3883752	c.7591C>T	p.R2531W	Substitution - Missense	Stomach
COSM21293	c.2607C>T	p.R869R	Substitution - coding silent	Large_intestine
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM1230641	c.5786G>A	p.R1929Q	Substitution - Missense	Stomach
COSM3883782	c.11340C>A	p.S3780S	Substitution - coding silent	Stomach
COSM3675005	c.7224-1G>T	p.?	Unknown	Prostate
COSM4458576	c.10813C>T	p.L3605F	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1623357	c.6768C>T	p.I2256I	Substitution - coding silent	Liver
COSM1635515	c.6919A>G	p.M2307V	Substitution - Missense	Liver
COSM5643280	c.10966G>A	p.V3656I	Substitution - Missense	Oesophagus
COSM5358187	c.8718C>T	p.H2906H	Substitution - coding silent	Large_intestine
COSM1093725	c.11055A>G	p.I3685M	Substitution - Missense	Endometrium
COSM5997509	c.9353A>G	p.Q3118R	Substitution - Missense	Prostate
COSM235525	c.7365C>T	p.R2455R	Substitution - coding silent	Skin
COSM20551	c.5117G>A	p.R1706H	Substitution - Missense	Stomach
COSM5575742	c.622G>A	p.E208K	Substitution - Missense	Stomach
COSM5413498	c.5812A>G	p.T1938A	Substitution - Missense	Skin
COSM1093609	c.3717C>T	p.H1239H	Substitution - coding silent	Endometrium
COSM3642814	c.7795C>T	p.L2599L	Substitution - coding silent	Skin
COSM1093663	c.7323C>A	p.F2441L	Substitution - Missense	Endometrium
COSM3642834	c.9860C>T	p.S3287F	Substitution - Missense	Skin
COSM1453172	c.4464C>T	p.S1488S	Substitution - coding silent	Large_intestine
COSM5635391	c.8117A>C	p.K2706T	Substitution - Missense	Oesophagus
COSM4805501	c.8853G>T	p.T2951T	Substitution - coding silent	Liver
COSM1488821	c.7959G>A	p.A2653A	Substitution - coding silent	Breast
COSM1268750	c.10431G>A	p.V3477V	Substitution - coding silent	Oesophagus
COSM3374709	c.998T>C	p.I333T	Substitution - Missense	Thyroid
COSM3412549	c.9648G>A	p.S3216S	Substitution - coding silent	Central_nervous_system
COSM2866915	c.11301C>T	p.A3767A	Substitution - coding silent	Skin
COSM2866740	c.7349G>T	p.R2450L	Substitution - Missense	Large_intestine
COSM4884883	c.9885G>A	p.Q3295Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM5915745	c.9682-8C>T	p.?	Unknown	Skin
COSM21306	c.5741C>T	p.P1914L	Substitution - Missense	Large_intestine
COSM393043	c.7324G>A	p.E2442K	Substitution - Missense	Lung
COSM1197630	c.3621G>C	p.K1207N	Substitution - Missense	Lung
COSM1230627	c.8276C>T	p.A2759V	Substitution - Missense	Large_intestine
COSM3431918	c.4686C>T	p.N1562N	Substitution - coding silent	Large_intestine
COSM3642844	c.10947G>A	p.L3649L	Substitution - coding silent	Skin
COSM3924319	c.10057C>T	p.L3353L	Substitution - coding silent	Skin
COSM4820286	c.679G>A	p.E227K	Substitution - Missense	Cervix
COSM80690	c.5946C>T	p.I1982I	Substitution - coding silent	Ovary
COSM4391539	c.461T>C	p.F154S	Substitution - Missense	Breast
COSM4456605	c.10079C>T	p.S3360L	Substitution - Missense	Skin
COSM1698984	c.7846C>T	p.P2616S	Substitution - Missense	Skin
COSM4564313	c.11142_11143GG>AA	p.V3715I	Substitution - Missense	Skin
COSM1623364	c.10468C>T	p.R3490W	Substitution - Missense	Liver
COSM4899796	c.454C>T	p.H152Y	Substitution - Missense	Skin
COSM3883750	c.7502C>T	p.P2501L	Substitution - Missense	Stomach
COSM1623357	c.6768C>T	p.I2256I	Substitution - coding silent	Liver
COSM4799310	c.151-1G>A	p.?	Unknown	Liver
COSM21306	c.5741C>T	p.P1914L	Substitution - Missense	Large_intestine
COSM21330	c.2544G>T	p.T848T	Substitution - coding silent	Ovary
COSM248902	c.2446C>T	p.R816W	Substitution - Missense	Pancreas
COSM1093612	c.4097G>A	p.R1366Q	Substitution - Missense	Endometrium
COSM3642850	c.11207A>G	p.K3736R	Substitution - Missense	Skin
COSM383501	c.6000G>T	p.L2000L	Substitution - coding silent	Lung
COSM3642816	c.7907C>T	p.P2636L	Substitution - Missense	Skin
COSM1093678	c.8287G>A	p.E2763K	Substitution - Missense	Endometrium
COSM1698976	c.2456C>T	p.S819L	Substitution - Missense	Skin
COSM4817124	c.10060G>C	p.E3354Q	Substitution - Missense	Cervix
COSM4736789	c.9130G>A	p.V3044M	Substitution - Missense	Large_intestine
COSM5586867	c.5575C>T	p.P1859S	Substitution - Missense	Skin
COSM3642826	c.9054C>T	p.I3018I	Substitution - coding silent	Skin
COSM485790	c.8108T>G	p.L2703R	Substitution - Missense	Kidney
COSM1635513	c.6907A>T	p.S2303C	Substitution - Missense	Liver
COSM3883694	c.541G>A	p.E181K	Substitution - Missense	Stomach
COSM3883754	c.7758G>T	p.E2586D	Substitution - Missense	Stomach
COSM4841991	c.9686G>C	p.G3229A	Substitution - Missense	Cervix
COSM5744946	c.8249G>A	p.R2750Q	Substitution - Missense	Pancreas
COSM1093684	c.8511C>T	p.C2837C	Substitution - coding silent	Endometrium
COSM1623353	c.3620A>T	p.K1207M	Substitution - Missense	Liver
COSM3698626	c.4902C>T	p.N1634N	Substitution - coding silent	Large_intestine
COSM40724	c.9595C>T	p.P3199S	Substitution - Missense	Central_nervous_system
COSM1698978	c.3257G>A	p.G1086E	Substitution - Missense	Skin
COSM3642763	c.3096G>A	p.K1032K	Substitution - coding silent	Skin
COSM4794057	c.1963G>A	p.V655I	Substitution - Missense	Liver
COSM5576201	c.2075A>G	p.Y692C	Substitution - Missense	Stomach
COSM453646	c.3742G>C	p.E1248Q	Substitution - Missense	Breast
COSM1453210	c.8248C>T	p.R2750W	Substitution - Missense	Large_intestine
COSM4396344	c.10453C>T	p.R3485W	Substitution - Missense	Skin
COSM3924309	c.1498C>T	p.P500S	Substitution - Missense	Skin
COSM1093566	c.1429C>G	p.L477V	Substitution - Missense	Endometrium
COSM1093551	c.529C>G	p.Q177E	Substitution - Missense	Endometrium
COSM1581865	c.1436C>T	p.A479V	Substitution - Missense	Large_intestine
COSM3669779	c.4411C>T	p.L1471L	Substitution - coding silent	Liver
COSM453642	c.3569T>A	p.V1190D	Substitution - Missense	Breast
COSM5997509	c.9353A>G	p.Q3118R	Substitution - Missense	Prostate
COSM4883936	c.5440C>A	p.L1814M	Substitution - Missense	Upper_aerodigestive_tract
COSM5746762	c.11182C>T	p.R3728W	Substitution - Missense	Pancreas
COSM3642822	c.8377C>T	p.P2793S	Substitution - Missense	Skin
COSM5753189	c.6037G>A	p.D2013N	Substitution - Missense	Pancreas
COSM21309	c.4312C>T	p.R1438W	Substitution - Missense	Large_intestine
COSM1453170	c.4415G>A	p.R1472H	Substitution - Missense	Large_intestine
COSM3883692	c.320G>A	p.R107H	Substitution - Missense	Stomach
COSM4799310	c.151-1G>A	p.?	Unknown	Liver
COSM3778723	c.4036G>A	p.E1346K	Substitution - Missense	Urinary_tract
COSM3883748	c.6625C>T	p.P2209S	Substitution - Missense	Stomach
COSM5062704	c.7603G>A	p.E2535K	Substitution - Missense	Stomach
COSM3642755	c.1965C>T	p.V655V	Substitution - coding silent	Skin
COSM1187374	c.8989A>T	p.S2997C	Substitution - Missense	Lung
COSM2866901	c.11148C>T	p.S3716S	Substitution - coding silent	Skin
COSM3642832	c.9528T>C	p.L3176L	Substitution - coding silent	Skin
COSM1453142	c.833C>T	p.A278V	Substitution - Missense	Large_intestine
COSM5010037	c.5427G>A	p.S1809S	Substitution - coding silent	Large_intestine
COSM1093699	c.9129C>T	p.I3043I	Substitution - coding silent	Endometrium
COSM3642798	c.6504C>T	p.I2168I	Substitution - coding silent	Skin
COSM233662	c.11141G>A	p.G3714E	Substitution - Missense	Skin
COSM3883700	c.1216A>G	p.I406V	Substitution - Missense	Stomach
COSM5408354	c.3497T>A	p.F1166Y	Substitution - Missense	Skin
COSM2866534	c.2525T>C	p.V842A	Substitution - Missense	Large_intestine
COSM3665282	c.2466G>A	p.P822P	Substitution - coding silent	Oesophagus
COSM4795900	c.4800G>A	p.G1600G	Substitution - coding silent	Liver
COSM5734310	c.4184A>T	p.N1395I	Substitution - Missense	Pancreas
COSM3642826	c.9054C>T	p.I3018I	Substitution - coding silent	Large_intestine
COSM3883692	c.320G>A	p.R107H	Substitution - Missense	Stomach
COSM3883784	c.11388C>T	p.L3796L	Substitution - coding silent	Liver
COSM421836	c.5113G>C	p.G1705R	Substitution - Missense	Urinary_tract
COSM4560814	c.8545G>A	p.E2849K	Substitution - Missense	Skin
COSM4609356	c.9894G>T	p.W3298C	Substitution - Missense	Adrenal_gland
COSM5997378	c.8402T>C	p.L2801P	Substitution - Missense	Prostate
COSM748345	c.3004A>G	p.I1002V	Substitution - Missense	Lung
COSM4736775	c.5317G>A	p.E1773K	Substitution - Missense	Large_intestine
COSM20664	c.2677C>T	p.R893C	Substitution - Missense	Ovary
COSM258257	c.629G>A	p.R210Q	Substitution - Missense	Liver
COSM318185	c.7938G>A	p.Q2646Q	Substitution - coding silent	Soft_tissue
COSM4736781	c.6345G>A	p.A2115A	Substitution - coding silent	Large_intestine
COSM3642846	c.10999T>C	p.L3667L	Substitution - coding silent	Skin
COSM1093539	c.88G>A	p.D30N	Substitution - Missense	Endometrium
COSM4604103	c.11371A>C	p.T3791P	Substitution - Missense	Upper_aerodigestive_tract
COSM4805501	c.8853G>T	p.T2951T	Substitution - coding silent	Liver
COSM20429	c.9809G>A	p.R3270H	Substitution - Missense	Large_intestine
COSM20429	c.9809G>A	p.R3270H	Substitution - Missense	Endometrium
COSM4506908	c.7276C>T	p.L2426F	Substitution - Missense	Skin
COSM4153123	c.10105G>A	p.E3369K	Substitution - Missense	Kidney
COSM5611406	c.5355_5356CC>TT	p.P1786S	Substitution - Missense	Skin
COSM1268746	c.11140G>A	p.G3714R	Substitution - Missense	Oesophagus
COSM1313461	c.3423C>T	p.I1141I	Substitution - coding silent	Urinary_tract
COSM3883762	c.8841C>T	p.H2947H	Substitution - coding silent	Stomach
COSM3883734	c.5430G>C	p.L1810L	Substitution - coding silent	Stomach
COSM4515377	c.10688_10689CC>TT	p.S3563F	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM2866692	c.6302G>A	p.G2101E	Substitution - Missense	Large_intestine
COSM5611070	c.687C>T	p.P229P	Substitution - coding silent	Skin
COSM5062702	c.2534G>A	p.G845D	Substitution - Missense	Stomach
COSM1623364	c.10468C>T	p.R3490W	Substitution - Missense	Liver
COSM3883776	c.10855C>T	p.R3619C	Substitution - Missense	Stomach
COSM1453158	c.3406C>T	p.P1136S	Substitution - Missense	Large_intestine
COSM20664	c.2677C>T	p.R893C	Substitution - Missense	Ovary
COSM1162121	c.9006G>A	p.M3002I	Substitution - Missense	Kidney
COSM5368562	c.9319G>A	p.E3107K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1230619	c.1847G>A	p.R616H	Substitution - Missense	Ovary
COSM2866756	c.7664C>T	p.T2555M	Substitution - Missense	Stomach
COSM3765375	c.2878C>T	p.R960W	Substitution - Missense	Breast
COSM4493395	c.4146C>T	p.S1382S	Substitution - coding silent	Skin
COSM1093684	c.8511C>T	p.C2837C	Substitution - coding silent	Large_intestine
COSM5500430	c.152A>G	p.N51S	Substitution - Missense	Biliary_tract
COSM5475105	c.5983G>A	p.V1995I	Substitution - Missense	Large_intestine
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Upper_aerodigestive_tract
COSM3663430	c.7004C>A	p.S2335Y	Substitution - Missense	Liver
COSM5695401	c.5427G>T	p.S1809S	Substitution - coding silent	Soft_tissue
COSM5002843	c.9748G>A	p.E3250K	Substitution - Missense	Pancreas
COSM1093563	c.1356C>T	p.F452F	Substitution - coding silent	Endometrium
COSM3883710	c.2632C>T	p.R878C	Substitution - Missense	Stomach
COSM1093639	c.5194C>T	p.R1732C	Substitution - Missense	Endometrium
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM1093557	c.780T>G	p.I260M	Substitution - Missense	Endometrium
COSM1093734	c.11101C>T	p.R3701*	Substitution - Nonsense	Endometrium
COSM2866562	c.2947G>A	p.A983T	Substitution - Missense	Stomach
COSM2866756	c.7664C>T	p.T2555M	Substitution - Missense	Large_intestine
COSM3669779	c.4411C>T	p.L1471L	Substitution - coding silent	Liver
COSM4736791	c.9477G>A	p.R3159R	Substitution - coding silent	Large_intestine
COSM5611076	c.3362T>C	p.V1121A	Substitution - Missense	Skin
COSM1757204	c.2600C>T	p.P867L	Substitution - Missense	Urinary_tract
COSM3883724	c.4473C>T	p.N1491N	Substitution - coding silent	Stomach
COSM3642741	c.540C>A	p.P180P	Substitution - coding silent	Skin
COSM5611060	c.2373C>T	p.N791N	Substitution - coding silent	Skin
COSM1093696	c.9070C>T	p.L3024L	Substitution - coding silent	Endometrium
COSM3833583	c.6177G>A	p.S2059S	Substitution - coding silent	Breast
COSM3412547	c.9082G>A	p.A3028T	Substitution - Missense	Central_nervous_system
COSM4736795	c.10901C>T	p.T3634M	Substitution - Missense	Large_intestine
COSM2866756	c.7664C>T	p.T2555M	Substitution - Missense	Stomach
COSM2866772	c.7957G>A	p.A2653T	Substitution - Missense	Large_intestine
COSM3663430	c.7004C>A	p.S2335Y	Substitution - Missense	Liver
COSM4430887	c.4156A>T	p.I1386F	Substitution - Missense	Oesophagus
COSM5408348	c.559C>T	p.P187S	Substitution - Missense	Skin
COSM5498972	c.7114C>T	p.R2372W	Substitution - Missense	Biliary_tract
COSM4521951	c.11295G>T	p.S3765S	Substitution - coding silent	Skin
COSM2866901	c.11148C>T	p.S3716S	Substitution - coding silent	Skin
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Skin
COSM5576203	c.8165C>T	p.P2722L	Substitution - Missense	Stomach
COSM379428	c.8459C>T	p.T2820M	Substitution - Missense	Lung
COSM3642745	c.1152C>T	p.H384H	Substitution - coding silent	Skin
COSM4888262	c.10138C>A	p.Q3380K	Substitution - Missense	Upper_aerodigestive_tract
COSM5611048	c.8119C>T	p.P2707S	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM4654296	c.6626C>A	p.P2209Q	Substitution - Missense	Large_intestine
COSM5768662	c.170A>G	p.Q57R	Substitution - Missense	Breast
COSM2866883	c.10818C>T	p.R3606R	Substitution - coding silent	Stomach
COSM1093699	c.9129C>T	p.I3043I	Substitution - coding silent	Endometrium
COSM3642812	c.7531G>A	p.D2511N	Substitution - Missense	Skin
COSM2866646	c.5364C>T	p.S1788S	Substitution - coding silent	Large_intestine
COSM1313465	c.5344G>C	p.E1782Q	Substitution - Missense	Urinary_tract
COSM5611042	c.10283A>C	p.K3428T	Substitution - Missense	Skin
COSM5611080	c.3597C>T	p.S1199S	Substitution - coding silent	Skin
COSM5483273	c.7997C>T	p.P2666L	Substitution - Missense	Large_intestine
COSM2866660	c.5496C>T	p.N1832N	Substitution - coding silent	Large_intestine
COSM1241853	c.1465A>G	p.T489A	Substitution - Missense	Oesophagus
COSM5905736	c.3176-8C>T	p.?	Unknown	Skin
COSM5731657	c.8359G>A	p.E2787K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1581869	c.6070G>A	p.V2024I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4736783	c.7878G>A	p.Q2626Q	Substitution - coding silent	Large_intestine
COSM5468843	c.4014+10T>G	p.?	Unknown	Large_intestine
COSM1230637	c.4339C>T	p.R1447C	Substitution - Missense	Skin
COSM20712	c.5786G>T	p.R1929L	Substitution - Missense	Ovary
COSM1664720	c.6190G>A	p.D2064N	Substitution - Missense	Kidney
COSM199157	c.7256C>T	p.A2419V	Substitution - Missense	Large_intestine
COSM3951013	c.420C>T	p.H140H	Substitution - coding silent	Lung
COSM5640948	c.10140A>G	p.Q3380Q	Substitution - coding silent	Oesophagus
COSM5611074	c.1295C>T	p.S432F	Substitution - Missense	Skin
COSM5358313	c.5683G>A	p.A1895T	Substitution - Missense	Large_intestine
COSM5653657	c.4218A>T	p.E1406D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM20712	c.5786G>T	p.R1929L	Substitution - Missense	Ovary
COSM5358187	c.8718C>T	p.H2906H	Substitution - coding silent	Large_intestine
COSM316223	c.8288A>T	p.E2763V	Substitution - Missense	Lung
COSM3833573	c.1623C>T	p.F541F	Substitution - coding silent	Breast
COSM3883720	c.4147A>G	p.R1383G	Substitution - Missense	Stomach
COSM1757202	c.634-2A>T	p.?	Unknown	Urinary_tract
COSM5139802	c.10237delA	p.K3414fs*19	Deletion - Frameshift	Large_intestine
COSM1230631	c.7067G>T	p.W2356L	Substitution - Missense	Large_intestine
COSM5611086	c.2580C>T	p.F860F	Substitution - coding silent	Skin
COSM3665282	c.2466G>A	p.P822P	Substitution - coding silent	Oesophagus
COSM2866625	c.4870G>T	p.A1624S	Substitution - Missense	Upper_aerodigestive_tract
COSM1093660	c.7162C>T	p.R2388C	Substitution - Missense	Endometrium
COSM346018	c.8218G>T	p.E2740*	Substitution - Nonsense	Lung
COSM1093681	c.8378C>T	p.P2793L	Substitution - Missense	Endometrium
COSM5444339	c.5572G>T	p.D1858Y	Substitution - Missense	Oesophagus
COSM3642743	c.994C>T	p.L332L	Substitution - coding silent	Skin
COSM3703319	c.1747C>A	p.P583T	Substitution - Missense	Liver
COSM5017221	c.5182A>G	p.I1728V	Substitution - Missense	Kidney
COSM136615	c.3043C>T	p.R1015W	Substitution - Missense	Large_intestine
COSM5928990	c.628C>T	p.R210*	Substitution - Nonsense	Skin
COSM5937326	c.2488C>T	p.P830S	Substitution - Missense	Skin
COSM1330436	c.4143G>T	p.Q1381H	Substitution - Missense	Ovary
COSM137942	c.280C>T	p.L94F	Substitution - Missense	Skin
COSM5432243	c.6275A>T	p.D2092V	Substitution - Missense	Oesophagus
COSM5611408	c.6098_6099CC>TT	p.S2033F	Substitution - Missense	Skin
COSM3883740	c.6280A>G	p.T2094A	Substitution - Missense	Stomach
COSM3883704	c.1980G>T	p.E660D	Substitution - Missense	Stomach
COSM4736767	c.2409G>T	p.K803N	Substitution - Missense	Large_intestine
COSM1176879	c.3251C>T	p.S1084L	Substitution - Missense	Skin
COSM5062708	c.11175G>A	p.A3725A	Substitution - coding silent	Stomach
COSM5575878	c.10447G>A	p.A3483T	Substitution - Missense	Stomach
COSM233660	c.9916G>A	p.E3306K	Substitution - Missense	Skin
COSM1230617	c.7351C>T	p.R2451C	Substitution - Missense	Large_intestine
COSM1313459	c.2866G>A	p.E956K	Substitution - Missense	Urinary_tract
COSM4736773	c.3162C>T	p.V1054V	Substitution - coding silent	Large_intestine
COSM5408352	c.2165_2166CC>TT	p.S722F	Substitution - Missense	Skin
COSM1453156	c.2976C>T	p.N992N	Substitution - coding silent	Large_intestine
COSM4795900	c.4800G>A	p.G1600G	Substitution - coding silent	Liver
COSM1179644	c.8399A>G	p.Q2800R	Substitution - Missense	Prostate
COSM1093563	c.1356C>T	p.F452F	Substitution - coding silent	Skin
COSM5955210	c.9945G>A	p.L3315L	Substitution - coding silent	Upper_aerodigestive_tract
COSM1686541	c.8423+2T>A	p.?	Unknown	Skin
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM5925390	c.3136A>G	p.I1046V	Substitution - Missense	Skin
COSM3642776	c.4513C>T	p.L1505L	Substitution - coding silent	Skin
COSM3642784	c.5009C>T	p.T1670I	Substitution - Missense	Skin
COSM1230639	c.5699C>T	p.A1900V	Substitution - Missense	Large_intestine
COSM5358523	c.9676A>G	p.S3226G	Substitution - Missense	Large_intestine
COSM2866584	c.3678A>T	p.R1226S	Substitution - Missense	Large_intestine
COSM4736771	c.2889G>A	p.A963A	Substitution - coding silent	Large_intestine
COSM3412543	c.6147C>T	p.A2049A	Substitution - coding silent	Central_nervous_system
COSM255880	c.3682G>A	p.E1228K	Substitution - Missense	Central_nervous_system
COSM3883706	c.2222A>T	p.N741I	Substitution - Missense	Stomach
COSM4631247	c.4988G>A	p.R1663H	Substitution - Missense	Large_intestine
COSM5031987	c.9187G>T	p.V3063F	Substitution - Missense	Pancreas
COSM5611044	c.3310G>A	p.E1104K	Substitution - Missense	Skin
COSM3924321	c.11090C>T	p.P3697L	Substitution - Missense	Skin
COSM3698634	c.10074C>T	p.N3358N	Substitution - coding silent	Large_intestine
COSM3642826	c.9054C>T	p.I3018I	Substitution - coding silent	Skin
COSM2866572	c.3474delG	p.G1160fs*25	Deletion - Frameshift	Large_intestine
COSM98837	c.8549C>T	p.A2850V	Substitution - Missense	Stomach
COSM1093642	c.5554C>T	p.L1852F	Substitution - Missense	Endometrium
COSM2866550	c.2699G>A	p.G900D	Substitution - Missense	Large_intestine
COSM5423269	c.3448T>A	p.Y1150N	Substitution - Missense	Prostate
COSM1268752	c.520G>A	p.E174K	Substitution - Missense	Stomach
COSM4820455	c.3819G>T	p.K1273N	Substitution - Missense	Cervix
COSM3734847	c.367-10delT	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3394972	c.7057G>A	p.V2353M	Substitution - Missense	Pancreas
COSM3738321	c.1115+10T>G	p.?	Unknown	Soft_tissue
COSM5413492	c.4603C>T	p.P1535S	Substitution - Missense	Skin
COSM5891995	c.3176-7C>T	p.?	Unknown	Skin
COSM267649	c.10703A>G	p.Y3568C	Substitution - Missense	Large_intestine
COSM3698630	c.8797G>A	p.A2933T	Substitution - Missense	Large_intestine
COSM199146	c.4572G>A	p.T1524T	Substitution - coding silent	Large_intestine
COSM5776488	c.7764+9G>A	p.?	Unknown	Breast
COSM5718374	c.5964C>T	p.A1988A	Substitution - coding silent	Skin
COSM4399937	c.5335C>T	p.P1779S	Substitution - Missense	Skin
COSM1093624	c.4664T>G	p.F1555C	Substitution - Missense	Endometrium
COSM1093737	c.11174C>T	p.A3725V	Substitution - Missense	Endometrium
COSM5009098	c.8322C>A	p.S2774S	Substitution - coding silent	Large_intestine
COSM1093563	c.1356C>T	p.F452F	Substitution - coding silent	Large_intestine
COSM1330432	c.8048A>G	p.N2683S	Substitution - Missense	Stomach
COSM248026	c.155T>C	p.V52A	Substitution - Missense	Prostate
COSM1581865	c.1436C>T	p.A479V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5413490	c.3938C>T	p.T1313M	Substitution - Missense	Skin
COSM5710768	c.8583G>C	p.E2861D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5924450	c.7636G>A	p.E2546K	Substitution - Missense	Skin
COSM1093554	c.709C>A	p.Q237K	Substitution - Missense	Endometrium
COSM3883718	c.4079C>T	p.P1360L	Substitution - Missense	Stomach
COSM3642804	c.6744C>T	p.S2248S	Substitution - coding silent	Skin
COSM3833589	c.9594A>C	p.P3198P	Substitution - coding silent	Breast
COSM5611038	c.9174C>T	p.L3058L	Substitution - coding silent	Skin
COSM4794057	c.1963G>A	p.V655I	Substitution - Missense	Liver
COSM4942405	c.1223A>G	p.D408G	Substitution - Missense	Liver
COSM748339	c.4653A>G	p.T1551T	Substitution - coding silent	Lung
COSM4736785	c.8003T>A	p.I2668N	Substitution - Missense	Large_intestine
COSM1093699	c.9129C>T	p.I3043I	Substitution - coding silent	Skin
COSM748321	c.10299G>T	p.E3433D	Substitution - Missense	Lung
COSM4804454	c.9925A>T	p.R3309W	Substitution - Missense	Liver
COSM3883742	c.6350G>A	p.R2117Q	Substitution - Missense	Stomach
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM1488821	c.7959G>A	p.A2653A	Substitution - coding silent	Stomach
COSM4555836	c.6655G>A	p.E2219K	Substitution - Missense	Skin
COSM1757212	c.7624G>A	p.E2542K	Substitution - Missense	Urinary_tract
COSM1093545	c.142A>C	p.N48H	Substitution - Missense	Endometrium
COSM3642780	c.4866C>T	p.F1622F	Substitution - coding silent	Skin
COSM1230629	c.5C>T	p.A2V	Substitution - Missense	Large_intestine
COSM5413496	c.4782C>T	p.I1594I	Substitution - coding silent	Oesophagus
COSM1581873	c.10942G>T	p.A3648S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1698982	c.7556C>T	p.A2519V	Substitution - Missense	Skin
COSM1755451	c.4381G>C	p.D1461H	Substitution - Missense	Urinary_tract
COSM1732590	c.9880G>A	p.D3294N	Substitution - Missense	Soft_tissue
COSM3883764	c.8895C>T	p.D2965D	Substitution - coding silent	Large_intestine
COSM5611066	c.4150G>C	p.E1384Q	Substitution - Missense	Skin
COSM3642790	c.6098C>T	p.S2033F	Substitution - Missense	Skin
COSM5010039	c.9395A>T	p.D3132V	Substitution - Missense	Large_intestine
COSM42986	c.5805G>A	p.E1935E	Substitution - coding silent	Central_nervous_system
COSM3883784	c.11388C>T	p.L3796L	Substitution - coding silent	Stomach
COSM5009096	c.2856C>T	p.S952S	Substitution - coding silent	Large_intestine
COSM1093672	c.8171A>G	p.Q2724R	Substitution - Missense	Endometrium
COSM3642773	c.4314G>A	p.R1438R	Substitution - coding silent	Skin
COSM2866875	c.10752C>T	p.S3584S	Substitution - coding silent	Large_intestine
COSM4153119	c.7196T>C	p.F2399S	Substitution - Missense	Kidney
COSM1600197	c.3122T>A	p.F1041Y	Substitution - Missense	Central_nervous_system
COSM1453208	c.8193G>A	p.A2731A	Substitution - coding silent	Large_intestine
COSM4153121	c.8328A>C	p.E2776D	Substitution - Missense	Kidney
COSM5009092	c.1146C>T	p.L382L	Substitution - coding silent	Large_intestine
COSM1453180	c.4948C>T	p.R1650*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4877924	c.10967T>G	p.V3656G	Substitution - Missense	Prostate
COSM1093596	c.2983G>A	p.E995K	Substitution - Missense	Endometrium
COSM3883778	c.10954T>G	p.F3652V	Substitution - Missense	Stomach
COSM1453225	c.10179G>A	p.T3393T	Substitution - coding silent	Stomach
COSM2866726	c.7045G>A	p.V2349M	Substitution - Missense	Large_intestine
COSM4736793	c.10003_10004insC	p.H3337fs*33	Insertion - Frameshift	Large_intestine
COSM1488819	c.3485T>C	p.V1162A	Substitution - Missense	Breast
COSM5008080	c.4488C>T	p.C1496C	Substitution - coding silent	Large_intestine
COSM1757208	c.6348G>T	p.L2116F	Substitution - Missense	Urinary_tract
COSM303463	c.5473G>A	p.A1825T	Substitution - Missense	Central_nervous_system
COSM21293	c.2607C>T	p.R869R	Substitution - coding silent	Large_intestine
COSM1230619	c.1847G>A	p.R616H	Substitution - Missense	Large_intestine
COSM5416873	c.5198C>T	p.A1733V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1093593	c.2917G>T	p.A973S	Substitution - Missense	Endometrium
COSM5419173	c.3477G>A	p.G1159G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1453202	c.7665G>A	p.T2555T	Substitution - coding silent	Large_intestine
COSM316223	c.8288A>T	p.E2763V	Substitution - Missense	Soft_tissue
COSM2866782	c.8192C>T	p.A2731V	Substitution - Missense	Large_intestine
COSM21294	c.8738C>T	p.T2913M	Substitution - Missense	Large_intestine
COSM1568778	c.9966G>A	p.A3322A	Substitution - coding silent	Large_intestine
COSM3642786	c.5190G>A	p.Q1730Q	Substitution - coding silent	Skin
COSM3642806	c.6834C>T	p.S2278S	Substitution - coding silent	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM326779	c.3070G>T	p.G1024C	Substitution - Missense	Lung
COSM4385788	c.1291C>T	p.R431C	Substitution - Missense	Thyroid
COSM5746760	c.2222A>G	p.N741S	Substitution - Missense	Pancreas
COSM5345436	c.10534C>T	p.R3512*	Substitution - Nonsense	Large_intestine
COSM4797324	c.2008-1G>A	p.?	Unknown	Liver
COSM748351	c.1688G>A	p.G563D	Substitution - Missense	Lung
COSM1623355	c.3962G>T	p.R1321M	Substitution - Missense	Large_intestine
COSM5569521	c.7149T>G	p.T2383T	Substitution - coding silent	Prostate
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM485782	c.353T>C	p.F118S	Substitution - Missense	Kidney
COSM3642788	c.5646C>T	p.I1882I	Substitution - coding silent	Skin
COSM98243	c.4820G>A	p.R1607H	Substitution - Missense	Upper_aerodigestive_tract
COSM1093630	c.4850G>A	p.R1617H	Substitution - Missense	Endometrium
COSM5884613	c.2849T>C	p.L950P	Substitution - Missense	Large_intestine
COSM387791	c.3630G>T	p.L1210L	Substitution - coding silent	Lung
COSM2866722	c.6829C>T	p.R2277C	Substitution - Missense	Stomach
COSM4649151	c.8081A>G	p.H2694R	Substitution - Missense	Large_intestine
COSM300506	c.3910G>A	p.A1304T	Substitution - Missense	Liver
COSM2866821	c.9405G>A	p.E3135E	Substitution - coding silent	Large_intestine
COSM20478	c.4952G>A	p.R1651H	Substitution - Missense	Large_intestine
COSM4500432	c.5604C>T	p.L1868L	Substitution - coding silent	Skin
COSM1093599	c.3072C>T	p.G1024G	Substitution - coding silent	Endometrium
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Large_intestine
COSM3394974	c.9903A>C	p.E3301D	Substitution - Missense	Pancreas
COSM5062700	c.1762A>T	p.I588F	Substitution - Missense	Stomach
COSM2866901	c.11148C>T	p.S3716S	Substitution - coding silent	Skin
COSM340007	c.5061-1G>C	p.?	Unknown	Lung
COSM3642767	c.3731A>G	p.D1244G	Substitution - Missense	Skin
COSM4736777	c.5982C>T	p.V1994V	Substitution - coding silent	Large_intestine
COSM4851108	c.4987C>T	p.R1663C	Substitution - Missense	Cervix
COSM1313467	c.9118A>G	p.T3040A	Substitution - Missense	Urinary_tract
COSM1720799	c.5114G>A	p.G1705D	Substitution - Missense	Skin
COSM2866901	c.11148C>T	p.S3716S	Substitution - coding silent	Skin
COSM4458576	c.10813C>T	p.L3605F	Substitution - Missense	Skin
COSM293795	c.8519G>A	p.R2840Q	Substitution - Missense	Large_intestine
COSM20426	c.6850C>T	p.R2284W	Substitution - Missense	Large_intestine
COSM1724681	c.8347delA	p.E2785fs*29	Deletion - Frameshift	Skin
COSM3883716	c.4009A>G	p.T1337A	Substitution - Missense	Stomach
COSM80691	c.7782C>T	p.S2594S	Substitution - coding silent	Ovary
COSM1623353	c.3620A>T	p.K1207M	Substitution - Missense	Liver
COSM4402800	c.5538C>T	p.F1846F	Substitution - coding silent	Skin
COSM1162121	c.9006G>A	p.M3002I	Substitution - Missense	Kidney
COSM1093731	c.11074C>T	p.L3692L	Substitution - coding silent	Endometrium
COSM264225	c.8422C>T	p.R2808*	Substitution - Nonsense	Large_intestine
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Skin
COSM1093744	c.11403C>T	p.G3801G	Substitution - coding silent	Endometrium
COSM5423214	c.4292T>C	p.L1431P	Substitution - Missense	Prostate
COSM5009474	c.5494A>T	p.N1832Y	Substitution - Missense	Large_intestine
COSM5611062	c.6763A>G	p.M2255V	Substitution - Missense	Skin
COSM5009894	c.454C>A	p.H152N	Substitution - Missense	Large_intestine
COSM2866907	c.11252C>T	p.A3751V	Substitution - Missense	Stomach
COSM4970112	c.4581G>A	p.A1527A	Substitution - coding silent	Central_nervous_system
COSM4587647	c.1372A>G	p.T458A	Substitution - Missense	Bone
COSM5009090	c.448G>T	p.E150*	Substitution - Nonsense	Large_intestine
COSM2866600	c.4086C>T	p.L1362L	Substitution - coding silent	Skin
COSM1093572	c.1705G>T	p.A569S	Substitution - Missense	Endometrium
COSM360331	c.8052C>G	p.L2684L	Substitution - coding silent	Lung
COSM199165	c.10456C>T	p.R3486W	Substitution - Missense	Small_intestine
COSM2866418	c.18A>T	p.T6T	Substitution - coding silent	Large_intestine
COSM3394972	c.7057G>A	p.V2353M	Substitution - Missense	Soft_tissue
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM748347	c.2718G>A	p.L906L	Substitution - coding silent	Skin
COSM3883736	c.5574C>G	p.D1858E	Substitution - Missense	Stomach
COSM3642749	c.1577C>T	p.P526L	Substitution - Missense	Skin
COSM98971	c.355C>T	p.R119C	Substitution - Missense	Stomach
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Large_intestine
COSM1623355	c.3962G>T	p.R1321M	Substitution - Missense	Large_intestine
COSM4885039	c.8912G>T	p.S2971I	Substitution - Missense	Upper_aerodigestive_tract
COSM5710766	c.5078T>C	p.I1693T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5559259	c.9300G>C	p.L3100F	Substitution - Missense	Prostate
COSM5611034	c.10689C>T	p.S3563S	Substitution - coding silent	Skin
COSM1093687	c.8577G>A	p.P2859P	Substitution - coding silent	Endometrium
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM3642765	c.3119C>T	p.P1040L	Substitution - Missense	Skin
COSM4587653	c.7564A>G	p.T2522A	Substitution - Missense	Bone
COSM5593628	c.5663A>T	p.H1888L	Substitution - Missense	Skin
COSM98971	c.355C>T	p.R119C	Substitution - Missense	Upper_aerodigestive_tract
COSM4493531	c.4170C>T	p.L1390L	Substitution - coding silent	Skin
COSM5611078	c.5819C>T	p.P1940L	Substitution - Missense	Skin
COSM238563	c.6023C>T	p.P2008L	Substitution - Missense	Prostate
COSM199169	c.11397C>T	p.F3799F	Substitution - coding silent	Skin
COSM4587649	c.5088G>A	p.L1696L	Substitution - coding silent	Bone
COSM5611054	c.585G>A	p.T195T	Substitution - coding silent	Skin
COSM3883760	c.8296G>A	p.G2766R	Substitution - Missense	Stomach
COSM3942414	c.1296C>T	p.S432S	Substitution - coding silent	Oesophagus
COSM4835550	c.379G>C	p.E127Q	Substitution - Missense	Cervix
COSM1093705	c.9360C>T	p.H3120H	Substitution - coding silent	Endometrium
COSM3883770	c.9724A>G	p.T3242A	Substitution - Missense	Stomach
COSM748335	c.6094C>A	p.L2032M	Substitution - Missense	Lung
COSM5413494	c.4742C>T	p.P1581L	Substitution - Missense	Skin
COSM81845	c.5865G>A	p.V1955V	Substitution - coding silent	Ovary
COSM5408360	c.6194C>T	p.S2065F	Substitution - Missense	Skin
COSM5510236	c.367-10_367-9insT	p.?	Unknown	Biliary_tract
COSM1453148	c.2541G>A	p.R847R	Substitution - coding silent	Large_intestine
COSM1197630	c.3621G>C	p.K1207N	Substitution - Missense	Lung
COSM5413488	c.3588A>C	p.G1196G	Substitution - coding silent	Skin
COSM238353	c.8610C>T	p.R2870R	Substitution - coding silent	Prostate
COSM3768591	c.6545G>A	p.C2182Y	Substitution - Missense	Liver
COSM3698632	c.10064A>C	p.N3355T	Substitution - Missense	Large_intestine
COSM1093648	c.5829C>G	p.V1943V	Substitution - coding silent	Endometrium
COSM5710764	c.2048C>T	p.A683V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM4385788	c.1291C>T	p.R431C	Substitution - Missense	Skin
COSM1093702	c.9152G>A	p.R3051Q	Substitution - Missense	Endometrium
COSM1453225	c.10179G>A	p.T3393T	Substitution - coding silent	Large_intestine
COSM4515022	c.9864C>T	p.S3288S	Substitution - coding silent	Skin
COSM1757202	c.634-2A>T	p.?	Unknown	Urinary_tract
COSM3778719	c.154G>A	p.V52I	Substitution - Missense	Urinary_tract
COSM1093666	c.7939C>T	p.R2647W	Substitution - Missense	Endometrium
COSM485792	c.9282A>G	p.A3094A	Substitution - coding silent	Kidney
COSM360333	c.9843C>A	p.L3281L	Substitution - coding silent	Lung
COSM4797324	c.2008-1G>A	p.?	Unknown	Liver
COSM2866680	c.5956C>T	p.R1986W	Substitution - Missense	Large_intestine
COSM1166176	c.3127G>A	p.A1043T	Substitution - Missense	Large_intestine
COSM748327	c.8851A>G	p.T2951A	Substitution - Missense	Lung
COSM248902	c.2446C>T	p.R816W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1093740	c.11280G>A	p.T3760T	Substitution - coding silent	Endometrium
COSM379426	c.6005G>T	p.R2002M	Substitution - Missense	Lung
COSM141207	c.5175T>A	p.N1725K	Substitution - Missense	Upper_aerodigestive_tract
COSM3642826	c.9054C>T	p.I3018I	Substitution - coding silent	Skin
COSM76840	c.10258G>C	p.E3420Q	Substitution - Missense	Ovary
COSM360329	c.2524G>T	p.V842F	Substitution - Missense	Lung
COSM5968607	c.8493C>A	p.P2831P	Substitution - coding silent	Genital_tract
COSM1643442	c.6876G>A	p.A2292A	Substitution - coding silent	Stomach
COSM3642796	c.6486C>T	p.V2162V	Substitution - coding silent	Skin
COSM1093560	c.1117C>T	p.P373S	Substitution - Missense	Endometrium
COSM3642840	c.10698G>A	p.E3566E	Substitution - coding silent	Skin
COSM1093587	c.2534G>T	p.G845V	Substitution - Missense	Endometrium
COSM3642848	c.11178C>T	p.V3726V	Substitution - coding silent	Skin
COSM4759203	c.6797G>T	p.S2266I	Substitution - Missense	Stomach
COSM5408364	c.7960C>T	p.L2654L	Substitution - coding silent	Skin
COSM1635517	c.7153A>G	p.I2385V	Substitution - Missense	Liver
COSM1568782	c.5732C>T	p.P1911L	Substitution - Missense	Large_intestine
COSM3642820	c.8321C>T	p.S2774F	Substitution - Missense	Skin
COSM53527	c.8591G>T	p.W2864L	Substitution - Missense	Liver
COSM2866572	c.3474delG	p.G1160fs*25	Deletion - Frameshift	Large_intestine
COSM4901461	c.10666G>A	p.E3556K	Substitution - Missense	Skin
COSM342598	c.10360G>T	p.E3454*	Substitution - Nonsense	Lung
COSM748355	c.1195G>A	p.V399I	Substitution - Missense	Soft_tissue
COSM453644	c.3647G>A	p.R1216Q	Substitution - Missense	Endometrium
COSM1757206	c.6020A>T	p.Q2007L	Substitution - Missense	Urinary_tract
COSM4153115	c.632C>A	p.T211K	Substitution - Missense	Kidney
COSM5611056	c.1568C>T	p.P523L	Substitution - Missense	Skin
COSM1230633	c.10819G>A	p.D3607N	Substitution - Missense	Large_intestine
COSM1268748	c.369G>A	p.T123T	Substitution - coding silent	Stomach
COSM1673338	c.8980C>T	p.H2994Y	Substitution - Missense	Large_intestine
COSM165197	c.7201G>C	p.D2401H	Substitution - Missense	Breast
COSM223182	c.4432G>A	p.V1478M	Substitution - Missense	Skin
COSM1453162	c.3870delC	p.P1292fs*17	Deletion - Frameshift	Large_intestine
COSM1453176	c.4675G>A	p.A1559T	Substitution - Missense	Large_intestine
COSM5094857	c.10129G>C	p.A3377P	Substitution - Missense	Thymus
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Lung
COSM1673336	c.2087G>A	p.R696H	Substitution - Missense	Large_intestine
COSM5758693	c.3562C>A	p.L1188I	Substitution - Missense	Bone
COSM4885603	c.9336C>T	p.A3112A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4428336	c.520G>C	p.E174Q	Substitution - Missense	Oesophagus
COSM5809373	c.6289G>A	p.A2097T	Substitution - Missense	Liver
COSM3412541	c.3479G>T	p.G1160V	Substitution - Missense	Central_nervous_system
COSM199165	c.10456C>T	p.R3486W	Substitution - Missense	Large_intestine
COSM1093710	c.9876C>T	p.I3292I	Substitution - coding silent	Endometrium
COSM5518772	c.2241G>A	p.A747A	Substitution - coding silent	Biliary_tract
COSM5611084	c.1140C>T	p.A380A	Substitution - coding silent	Skin
COSM300506	c.3910G>A	p.A1304T	Substitution - Missense	Liver
COSM1093666	c.7939C>T	p.R2647W	Substitution - Missense	Large_intestine
COSM1230645	c.10853C>T	p.P3618L	Substitution - Missense	Pancreas
COSM3642769	c.3986T>G	p.V1329G	Substitution - Missense	Skin
COSM4736787	c.8678C>T	p.A2893V	Substitution - Missense	Large_intestine
COSM3883772	c.10287C>T	p.F3429F	Substitution - coding silent	Stomach
COSM5611024	c.5116C>G	p.R1706G	Substitution - Missense	Skin
COSM5419752	c.2267A>G	p.Y756C	Substitution - Missense	Liver
COSM3833575	c.3096G>T	p.K1032N	Substitution - Missense	Breast
COSM748337	c.5830C>T	p.H1944Y	Substitution - Missense	Lung
COSM5997230	c.3610G>A	p.A1204T	Substitution - Missense	Prostate
COSM1230637	c.4339C>T	p.R1447C	Substitution - Missense	Large_intestine
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM1187376	c.10453C>G	p.R3485G	Substitution - Missense	Lung
COSM3642830	c.9497C>T	p.S3166L	Substitution - Missense	Skin
COSM12943	c.8015C>T	p.P2672L	Substitution - Missense	Lung
COSM1453235	c.11154G>A	p.P3718P	Substitution - coding silent	Large_intestine
COSM4605856	c.7254G>T	p.T2418T	Substitution - coding silent	Upper_aerodigestive_tract
COSM5443878	c.9147G>C	p.K3049N	Substitution - Missense	Oesophagus
COSM4759198	c.2144A>T	p.K715M	Substitution - Missense	Stomach
COSM1230647	c.8387T>C	p.F2796S	Substitution - Missense	Large_intestine
COSM3669794	c.1136T>A	p.L379Q	Substitution - Missense	Liver
COSM4988941	c.2861A>G	p.N954S	Substitution - Missense	Soft_tissue
COSM5559051	c.7199T>C	p.L2400S	Substitution - Missense	Prostate
COSM3642810	c.7233C>A	p.T2411T	Substitution - coding silent	Skin
COSM1093599	c.3072C>T	p.G1024G	Substitution - coding silent	Stomach
COSM122136	c.2919C>T	p.A973A	Substitution - coding silent	Upper_aerodigestive_tract
COSM3883774	c.10683A>G	p.S3561S	Substitution - coding silent	Stomach
COSM3883696	c.773T>C	p.I258T	Substitution - Missense	Stomach
COSM1453233	c.11044C>T	p.R3682*	Substitution - Nonsense	Skin
COSM3924311	c.4510C>T	p.H1504Y	Substitution - Missense	Skin
COSM3358182	c.798G>A	p.A266A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM485794	c.10339G>C	p.A3447P	Substitution - Missense	Kidney
COSM3883756	c.7789G>A	p.V2597I	Substitution - Missense	Large_intestine
COSM5408356	c.4604C>T	p.P1535L	Substitution - Missense	Skin
COSM5611082	c.100C>T	p.P34S	Substitution - Missense	Skin
COSM20478	c.4952G>A	p.R1651H	Substitution - Missense	Large_intestine
COSM1453231	c.10913C>T	p.T3638M	Substitution - Missense	Large_intestine
COSM4877342	c.10959G>A	p.A3653A	Substitution - coding silent	Prostate
COSM1623355	c.3962G>T	p.R1321M	Substitution - Missense	Liver
COSM1623355	c.3962G>T	p.R1321M	Substitution - Missense	Liver
COSM5009419	c.8460G>A	p.T2820T	Substitution - coding silent	Large_intestine
COSM1623349	c.1536A>C	p.P512P	Substitution - coding silent	Liver
COSM4884920	c.10233G>T	p.K3411N	Substitution - Missense	Upper_aerodigestive_tract
COSM78705	c.8513C>T	p.A2838V	Substitution - Missense	Ovary
COSM122138	c.10827C>T	p.L3609L	Substitution - coding silent	Upper_aerodigestive_tract
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1093578	c.2238C>T	p.L746L	Substitution - coding silent	Endometrium
COSM5611046	c.3407C>T	p.P1136L	Substitution - Missense	Skin
COSM5611050	c.8151G>A	p.E2717E	Substitution - coding silent	Skin
COSM4626094	c.3431G>A	p.R1144H	Substitution - Missense	Large_intestine
COSM351684	c.648G>T	p.P216P	Substitution - coding silent	Lung
COSM5597770	c.6759C>T	p.T2253T	Substitution - coding silent	Skin
COSM4006802	c.4436T>G	p.V1479G	Substitution - Missense	Urinary_tract
COSM3924317	c.6594C>T	p.L2198L	Substitution - coding silent	Skin
COSM1093621	c.4651A>G	p.T1551A	Substitution - Missense	Endometrium
COSM2866625	c.4870G>T	p.A1624S	Substitution - Missense	Upper_aerodigestive_tract
COSM3642824	c.8499C>T	p.L2833L	Substitution - coding silent	Skin
COSM5997509	c.9353A>G	p.Q3118R	Substitution - Missense	Prostate
COSM485788	c.4894G>T	p.V1632L	Substitution - Missense	Kidney
COSM2866512	c.1972A>C	p.M658L	Substitution - Missense	Bone
COSM5413500	c.7968C>T	p.C2656C	Substitution - coding silent	Skin
COSM1230629	c.5C>T	p.A2V	Substitution - Missense	Stomach
COSM3698628	c.6136G>A	p.A2046T	Substitution - Missense	Large_intestine
COSM1093719	c.10365T>A	p.F3455L	Substitution - Missense	Endometrium
COSM4805249	c.4780A>G	p.I1594V	Substitution - Missense	Liver
COSM3785807	c.2940C>G	p.N980K	Substitution - Missense	Pancreas
COSM4491112	c.3749C>T	p.T1250I	Substitution - Missense	Skin
COSM4965690	c.3430C>T	p.R1144C	Substitution - Missense	Pancreas
COSM1623349	c.1536A>C	p.P512P	Substitution - coding silent	Liver
COSM316225	c.7957G>T	p.A2653S	Substitution - Missense	Lung
COSM1330432	c.8048A>G	p.N2683S	Substitution - Missense	Ovary
COSM21294	c.8738C>T	p.T2913M	Substitution - Missense	Large_intestine
COSM3883766	c.9053T>A	p.I3018N	Substitution - Missense	Stomach
COSM4610404	c.3103C>T	p.R1035W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM326779	c.3070G>T	p.G1024C	Substitution - Missense	Large_intestine
COSM1230641	c.5786G>A	p.R1929Q	Substitution - Missense	Large_intestine
COSM3669777	c.463C>T	p.L155L	Substitution - coding silent	Liver
COSM1230637	c.4339C>T	p.R1447C	Substitution - Missense	Skin
COSM4954669	c.10914G>A	p.T3638T	Substitution - coding silent	Liver
COSM242081	c.1937C>A	p.T646K	Substitution - Missense	Prostate
COSM4547477	c.4240G>A	p.E1414K	Substitution - Missense	Skin
COSM4459836	c.11340C>T	p.S3780S	Substitution - coding silent	Skin
COSM453644	c.3647G>A	p.R1216Q	Substitution - Missense	Breast
COSM5503275	c.8587G>A	p.A2863T	Substitution - Missense	Biliary_tract
COSM1093569	c.1682C>T	p.T561M	Substitution - Missense	Endometrium
COSM21309	c.4312C>T	p.R1438W	Substitution - Missense	Large_intestine
COSM1600197	c.3122T>A	p.F1041Y	Substitution - Missense	Central_nervous_system
COSM3883768	c.9183A>G	p.A3061A	Substitution - coding silent	Stomach
COSM4649149	c.7579G>A	p.E2527K	Substitution - Missense	Large_intestine
COSM248028	c.10383G>A	p.T3461T	Substitution - coding silent	Prostate
COSM5451923	c.871T>G	p.L291V	Substitution - Missense	Large_intestine
COSM4736769	c.2857G>A	p.A953T	Substitution - Missense	Large_intestine
COSM748355	c.1195G>A	p.V399I	Substitution - Missense	Lung
COSM3642788	c.5646C>T	p.I1882I	Substitution - coding silent	Skin
COSM4855032	c.9101G>A	p.R3034Q	Substitution - Missense	Cervix
COSM4988941	c.2861A>G	p.N954S	Substitution - Missense	Soft_tissue
COSM5509419	c.9997A>G	p.K3333E	Substitution - Missense	Biliary_tract
COSM5611072	c.9716C>T	p.P3239L	Substitution - Missense	Skin
COSM1166661	c.3508C>T	p.R1170W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5611026	c.7271C>T	p.A2424V	Substitution - Missense	Skin
COSM3778721	c.613G>C	p.E205Q	Substitution - Missense	Urinary_tract
COSM267647	c.4083A>G	p.S1361S	Substitution - coding silent	Large_intestine
COSM20426	c.6850C>T	p.R2284W	Substitution - Missense	Large_intestine
COSM366661	c.744T>G	p.A248A	Substitution - coding silent	Lung
COSM258257	c.629G>A	p.R210Q	Substitution - Missense	Large_intestine
COSM1230649	c.3163G>A	p.A1055T	Substitution - Missense	Large_intestine
COSM1698984	c.7846C>T	p.P2616S	Substitution - Missense	Skin
COSM5611052	c.9948G>A	p.A3316A	Substitution - coding silent	Skin
COSM453650	c.10624G>A	p.V3542M	Substitution - Missense	Breast
COSM3669777	c.463C>T	p.L155L	Substitution - coding silent	Liver
COSM5922660	c.6415-4G>T	p.?	Unknown	Skin
COSM3883712	c.2698G>A	p.G900S	Substitution - Missense	Stomach
COSM1093722	c.10965C>T	p.F3655F	Substitution - coding silent	Endometrium
COSM3642838	c.10202G>C	p.G3401A	Substitution - Missense	Skin
COSM1698980	c.6199C>T	p.L2067F	Substitution - Missense	Skin
COSM3642753	c.1845C>T	p.I615I	Substitution - coding silent	Skin
COSM3642761	c.3038C>T	p.P1013L	Substitution - Missense	Skin
COSM4162525	c.9966G>T	p.A3322A	Substitution - coding silent	Thyroid
COSM5368562	c.9319G>A	p.E3107K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1453158	c.3406C>T	p.P1136S	Substitution - Missense	Large_intestine
COSM1093590	c.2686G>A	p.G896S	Substitution - Missense	Endometrium
COSM1230625	c.4928A>G	p.H1643R	Substitution - Missense	Large_intestine
COSM3883780	c.11122G>T	p.E3708*	Substitution - Nonsense	Stomach
COSM3431924	c.7246G>A	p.E2416K	Substitution - Missense	Upper_aerodigestive_tract
COSM4736765	c.1471C>T	p.P491S	Substitution - Missense	Large_intestine
COSM20551	c.5117G>A	p.R1706H	Substitution - Missense	Large_intestine
COSM5010035	c.2794A>G	p.K932E	Substitution - Missense	Large_intestine
COSM5628149	c.22G>A	p.G8R	Substitution - Missense	Oesophagus
COSM3929285	c.784G>T	p.V262L	Substitution - Missense	Central_nervous_system
COSM3883746	c.6595T>C	p.S2199P	Substitution - Missense	Stomach
COSM264223	c.5274C>A	p.I1758I	Substitution - coding silent	Large_intestine
COSM4162521	c.1587G>A	p.K529K	Substitution - coding silent	Thyroid
COSM3703321	c.8008A>G	p.I2670V	Substitution - Missense	Liver
COSM1623359	c.7040G>T	p.R2347L	Substitution - Missense	Liver
COSM4926770	c.6771C>A	p.L2257L	Substitution - coding silent	Liver
COSM1720799	c.5114G>A	p.G1705D	Substitution - Missense	Skin
COSM1623361	c.7249C>T	p.L2417L	Substitution - coding silent	Liver
COSM3412539	c.2935G>C	p.D979H	Substitution - Missense	Central_nervous_system
COSM1093618	c.4161C>T	p.I1387I	Substitution - coding silent	Endometrium
COSM382493	c.5197G>T	p.A1733S	Substitution - Missense	Lung
COSM3765375	c.2878C>T	p.R960W	Substitution - Missense	Central_nervous_system
COSM1645086	c.6952G>T	p.A2318S	Substitution - Missense	Salivary_gland
COSM270408	c.6973C>T	p.R2325W	Substitution - Missense	Large_intestine
COSM421834	c.9615G>T	p.W3205C	Substitution - Missense	Urinary_tract
COSM3642753	c.1845C>T	p.I615I	Substitution - coding silent	Skin
COSM264225	c.8422C>T	p.R2808*	Substitution - Nonsense	Pituitary
COSM81846	c.9987G>T	p.V3329V	Substitution - coding silent	Ovary
COSM3883764	c.8895C>T	p.D2965D	Substitution - coding silent	Stomach
COSM5595488	c.6507C>T	p.L2169L	Substitution - coding silent	Skin
COSM3642818	c.8204C>T	p.S2735F	Substitution - Missense	Skin
COSM748319	c.10308C>A	p.C3436*	Substitution - Nonsense	Lung
COSM3883714	c.2918C>T	p.A973V	Substitution - Missense	Stomach
COSM248902	c.2446C>T	p.R816W	Substitution - Missense	Large_intestine
COSM5643609	c.6090A>T	p.R2030S	Substitution - Missense	Oesophagus
COSM1093687	c.8577G>A	p.P2859P	Substitution - coding silent	Endometrium
COSM5482141	c.5752G>A	p.E1918K	Substitution - Missense	Large_intestine
COSM5611040	c.388C>T	p.L130F	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM4887723	c.3011C>T	p.S1004L	Substitution - Missense	Upper_aerodigestive_tract
COSM1643444	c.9772+4C>T	p.?	Unknown	Stomach
COSM1330434	c.7583C>G	p.P2528R	Substitution - Missense	Ovary
COSM3642771	c.4260C>T	p.V1420V	Substitution - coding silent	Skin
COSM1093710	c.9876C>T	p.I3292I	Substitution - coding silent	Stomach
COSM3642753	c.1845C>T	p.I615I	Substitution - coding silent	Skin
COSM1093584	c.2368C>A	p.L790M	Substitution - Missense	Endometrium
COSM1757208	c.6348G>T	p.L2116F	Substitution - Missense	Urinary_tract
COSM2866927	c.11461C>T	p.R3821C	Substitution - Missense	Stomach
COSM748317	c.10328C>A	p.S3443*	Substitution - Nonsense	Lung
COSM267922	c.5467G>T	p.E1823*	Substitution - Nonsense	Large_intestine
COSM1093669	c.7998G>A	p.P2666P	Substitution - coding silent	Endometrium
COSM1093713	c.10254C>A	p.I3418I	Substitution - coding silent	Endometrium
COSM1453185	c.5238C>T	p.F1746F	Substitution - coding silent	Skin
COSM1623357	c.6768C>T	p.I2256I	Substitution - coding silent	Oesophagus
COSM3642778	c.4823C>T	p.P1608L	Substitution - Missense	Skin
COSM1093657	c.7100A>G	p.Q2367R	Substitution - Missense	Endometrium
COSM1453229	c.10854G>A	p.P3618P	Substitution - coding silent	Large_intestine
COSM3412545	c.7539C>T	p.H2513H	Substitution - coding silent	Central_nervous_system
COSM3942416	c.2587G>A	p.D863N	Substitution - Missense	Oesophagus
COSM5004253	c.4570A>C	p.T1524P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4149437	c.2485G>C	p.D829H	Substitution - Missense	Ovary
COSM4497222	c.4872C>T	p.A1624A	Substitution - coding silent	Skin
COSM1757210	c.7009A>G	p.I2337V	Substitution - Missense	Urinary_tract
COSM318185	c.7938G>A	p.Q2646Q	Substitution - coding silent	Lung
COSM4736763	c.647C>T	p.P216L	Substitution - Missense	Large_intestine
COSM381614	c.9558G>A	p.L3186L	Substitution - coding silent	Lung
COSM242083	c.2213A>C	p.K738T	Substitution - Missense	Prostate
COSM3412551	c.11236C>T	p.R3746W	Substitution - Missense	Central_nervous_system
COSM53527	c.8591G>T	p.W2864L	Substitution - Missense	Liver
COSM1230645	c.10853C>T	p.P3618L	Substitution - Missense	Large_intestine
COSM1453213	c.9187G>A	p.V3063I	Substitution - Missense	Large_intestine
COSM2866899	c.11108C>T	p.T3703M	Substitution - Missense	Large_intestine
COSM2866823	c.9441C>T	p.G3147G	Substitution - coding silent	Stomach
COSM1757212	c.7624G>A	p.E2542K	Substitution - Missense	Urinary_tract
COSM4153117	c.5790G>T	p.K1930N	Substitution - Missense	Kidney
COSM5686256	c.2257C>T	p.P753S	Substitution - Missense	Soft_tissue
COSM3642800	c.6615C>T	p.F2205F	Substitution - coding silent	Skin
COSM1093575	c.2004T>G	p.L668L	Substitution - coding silent	Endometrium
COSM1581867	c.2715G>T	p.M905I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3924313	c.5139C>T	p.F1713F	Substitution - coding silent	Skin
COSM3726511	c.1445C>G	p.A482G	Substitution - Missense	Lung
COSM748323	c.9531G>C	p.L3177F	Substitution - Missense	Lung
COSM3833571	c.516C>T	p.Y172Y	Substitution - coding silent	Breast
COSM5919467	c.6371C>T	p.S2124F	Substitution - Missense	Skin
COSM5968605	c.6866C>A	p.P2289H	Substitution - Missense	Genital_tract
COSM1757204	c.2600C>T	p.P867L	Substitution - Missense	Urinary_tract
COSM2866658	c.5472C>T	p.H1824H	Substitution - coding silent	Large_intestine
COSM1093651	c.6717C>T	p.Y2239Y	Substitution - coding silent	Endometrium
COSM3883728	c.4637G>A	p.R1546Q	Substitution - Missense	Stomach
COSM303465	c.7294G>A	p.A2432T	Substitution - Missense	Central_nervous_system
COSM1093536	c.30G>A	p.T10T	Substitution - coding silent	Endometrium
COSM1093690	c.8792T>A	p.I2931N	Substitution - Missense	Endometrium
COSM42986	c.5805G>A	p.E1935E	Substitution - coding silent	Central_nervous_system
COSM248024	c.8842G>T	p.D2948Y	Substitution - Missense	Prostate
COSM4606116	c.917C>G	p.S306C	Substitution - Missense	Upper_aerodigestive_tract
COSM3675003	c.3332G>T	p.G1111V	Substitution - Missense	Prostate
COSM1176879	c.3251C>T	p.S1084L	Substitution - Missense	Endometrium
COSM1093542	c.112A>C	p.K38Q	Substitution - Missense	Endometrium
COSM1093684	c.8511C>T	p.C2837C	Substitution - coding silent	Large_intestine
COSM4736797	c.11045G>A	p.R3682Q	Substitution - Missense	Large_intestine
COSM4611221	c.8346_8347insA	p.E2785fs*3	Insertion - Frameshift	Large_intestine
COSM3942420	c.9649G>C	p.E3217Q	Substitution - Missense	Oesophagus
COSM3698630	c.8797G>A	p.A2933T	Substitution - Missense	Cervix
COSM3833587	c.7418G>T	p.W2473L	Substitution - Missense	Breast
COSM1093548	c.183C>T	p.F61F	Substitution - coding silent	Endometrium
COSM21300	c.7323C>T	p.F2441F	Substitution - coding silent	Skin
COSM1093716	c.10314C>T	p.F3438F	Substitution - coding silent	Endometrium
COSM3883758	c.8067G>A	p.T2689T	Substitution - coding silent	Stomach
COSM4804454	c.9925A>T	p.R3309W	Substitution - Missense	Liver
COSM2866516	c.2021C>T	p.S674F	Substitution - Missense	Skin
COSM1243704	c.7891G>A	p.A2631T	Substitution - Missense	Large_intestine
COSM20550	c.477A>G	p.K159K	Substitution - coding silent	Stomach
COSM5891995	c.3176-7C>T	p.?	Unknown	Skin
COSM5368562	c.9319G>A	p.E3107K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1673334	c.662C>T	p.S221F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3642794	c.6418C>T	p.Q2140*	Substitution - Nonsense	Skin
COSM3883742	c.6350G>A	p.R2117Q	Substitution - Missense	Liver
COSM233662	c.11141G>A	p.G3714E	Substitution - Missense	Skin
COSM1313463	c.4182G>A	p.L1394L	Substitution - coding silent	Urinary_tract
COSM4822443	c.6394G>A	p.D2132N	Substitution - Missense	Cervix
COSM5413486	c.1197C>T	p.V399V	Substitution - coding silent	Skin
COSM1623349	c.1536A>C	p.P512P	Substitution - coding silent	Liver
COSM5586869	c.198C>T	p.I66I	Substitution - coding silent	Skin
COSM5518770	c.1547C>T	p.A516V	Substitution - Missense	Biliary_tract
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM1288664	c.5532G>C	p.M1844I	Substitution - Missense	Autonomic_ganglia
COSM1268754	c.679G>C	p.E227Q	Substitution - Missense	Stomach
COSM1093615	c.4103C>T	p.A1368V	Substitution - Missense	Endometrium
COSM1453144	c.1339C>T	p.R447W	Substitution - Missense	Small_intestine
COSM5009094	c.1713T>G	p.G571G	Substitution - coding silent	Large_intestine
COSM3833581	c.6139A>C	p.T2047P	Substitution - Missense	Breast
COSM1623364	c.10468C>T	p.R3490W	Substitution - Missense	Liver
COSM98838	c.10031A>G	p.K3344R	Substitution - Missense	Stomach
COSM142973	c.10919_10920GG>AA	p.R3640Q	Substitution - Missense	Skin
COSM255880	c.3682G>A	p.E1228K	Substitution - Missense	Central_nervous_system
COSM1230621	c.6580G>A	p.V2194I	Substitution - Missense	Large_intestine
COSM1755451	c.4381G>C	p.D1461H	Substitution - Missense	Urinary_tract
COSM3833569	c.207C>T	p.F69F	Substitution - coding silent	Breast
COSM5611030	c.9270C>A	p.A3090A	Substitution - coding silent	Skin
COSM3431924	c.7246G>A	p.E2416K	Substitution - Missense	Large_intestine
COSM5611412	c.4149_4150GG>AA	p.E1384K	Substitution - Missense	Skin
COSM1230635	c.3656C>T	p.T1219M	Substitution - Missense	Large_intestine
COSM1623349	c.1536A>C	p.P512P	Substitution - coding silent	Liver
COSM136615	c.3043C>T	p.R1015W	Substitution - Missense	Skin
COSM5408350	c.1497C>T	p.S499S	Substitution - coding silent	Skin
COSM1757210	c.7009A>G	p.I2337V	Substitution - Missense	Urinary_tract
COSM1180337	c.8219A>G	p.E2740G	Substitution - Missense	Prostate
COSM485784	c.1096A>G	p.T366A	Substitution - Missense	Kidney
COSM3942418	c.9285G>A	p.L3095L	Substitution - coding silent	Oesophagus
COSM1673340	c.10900A>G	p.T3634A	Substitution - Missense	Large_intestine
COSM5718374	c.5964C>T	p.A1988A	Substitution - coding silent	Skin
COSM1453215	c.9241T>G	p.L3081V	Substitution - Missense	Large_intestine
COSM1453189	c.5650C>A	p.L1884M	Substitution - Missense	Large_intestine
COSM2866564	c.2966C>A	p.A989E	Substitution - Missense	Liver
COSM1453160	c.3481G>A	p.V1161M	Substitution - Missense	Large_intestine
COSM1581871	c.8383A>G	p.I2795V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3642830	c.9497C>T	p.S3166L	Substitution - Missense	Skin
COSM4537128	c.2384G>C	p.S795T	Substitution - Missense	Skin
COSM5358313	c.5683G>A	p.A1895T	Substitution - Missense	Large_intestine
COSM1623361	c.7249C>T	p.L2417L	Substitution - coding silent	Liver
COSM2866901	c.11148C>T	p.S3716S	Substitution - coding silent	Skin
COSM1268744	c.11356G>A	p.V3786I	Substitution - Missense	Oesophagus
COSM5966770	c.5889G>T	p.L1963F	Substitution - Missense	Adrenal_gland
COSM2866893	c.10958C>T	p.A3653V	Substitution - Missense	Stomach
COSM4771683	c.6100G>A	p.V2034M	Substitution - Missense	Stomach
COSM20551	c.5117G>A	p.R1706H	Substitution - Missense	Stomach
COSM3833585	c.7389G>A	p.Q2463Q	Substitution - coding silent	Breast
COSM20550	c.477A>G	p.K159K	Substitution - coding silent	Stomach
COSM5915743	c.10812C>T	p.V3604V	Substitution - coding silent	Skin
COSM3642802	c.6616C>T	p.P2206S	Substitution - Missense	Skin
COSM1453185	c.5238C>T	p.F1746F	Substitution - coding silent	Large_intestine
COSM1757206	c.6020A>T	p.Q2007L	Substitution - Missense	Urinary_tract
COSM5408358	c.5325C>T	p.L1775L	Substitution - coding silent	Skin
COSM1093633	c.5006C>T	p.A1669V	Substitution - Missense	Endometrium
COSM3833577	c.3507G>A	p.E1169E	Substitution - coding silent	Breast
COSM3924315	c.6246C>T	p.F2082F	Substitution - coding silent	Skin
COSM2866680	c.5956C>T	p.R1986W	Substitution - Missense	Stomach
COSM4954669	c.10914G>A	p.T3638T	Substitution - coding silent	Liver
COSM3642747	c.1480C>T	p.P494S	Substitution - Missense	Skin
COSM3883744	c.6587G>T	p.S2196I	Substitution - Missense	Stomach
COSM748349	c.1945G>T	p.E649*	Substitution - Nonsense	Lung
COSM2866650	c.5436C>T	p.I1812I	Substitution - coding silent	Large_intestine
COSM5586867	c.5575C>T	p.P1859S	Substitution - Missense	Skin
COSM4793948	c.2447G>A	p.R816Q	Substitution - Missense	Liver
COSM4556276	c.6813G>A	p.L2271L	Substitution - coding silent	Skin
COSM1093693	c.8960C>T	p.A2987V	Substitution - Missense	Endometrium
COSM3642842	c.10899C>T	p.A3633A	Substitution - coding silent	Skin
COSM3642757	c.2293C>T	p.R765C	Substitution - Missense	Skin
COSM5408366	c.9384C>T	p.A3128A	Substitution - coding silent	Skin
COSM5611068	c.646delC	p.P216fs*7	Deletion - Frameshift	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM4408972	c.11397C>A	p.F3799L	Substitution - Missense	Liver
COSM1166661	c.3508C>T	p.R1170W	Substitution - Missense	Stomach
COSM1313469	c.10162A>G	p.K3388E	Substitution - Missense	Urinary_tract
COSM5611058	c.3477G>T	p.G1159G	Substitution - coding silent	Skin
COSM4168929	c.3475G>A	p.G1159R	Substitution - Missense	Peritoneum
COSM3883708	c.2253G>T	p.K751N	Substitution - Missense	Stomach
COSM4916336	c.8854G>A	p.V2952M	Substitution - Missense	Liver
COSM2866572	c.3474delG	p.G1160fs*25	Deletion - Frameshift	Large_intestine
COSM3778725	c.8947+7C>T	p.?	Unknown	Urinary_tract
COSM1093675	c.8226G>A	p.M2742I	Substitution - Missense	Endometrium
COSM4921582	c.4577G>T	p.R1526L	Substitution - Missense	Liver
COSM3642836	c.9959C>T	p.S3320F	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Skin
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Large_intestine
COSM300506	c.3910G>A	p.A1304T	Substitution - Missense	Large_intestine
COSM748347	c.2718G>A	p.L906L	Substitution - coding silent	Lung
COSM748357	c.212C>T	p.T71I	Substitution - Missense	Lung
COSM5435398	c.1545T>C	p.P515P	Substitution - coding silent	Oesophagus
COSM1093602	c.3256G>T	p.G1086*	Substitution - Nonsense	Endometrium
COSM286016	c.9424C>T	p.R3142W	Substitution - Missense	Large_intestine
COSM1230643	c.10766G>A	p.R3589Q	Substitution - Missense	Large_intestine
COSM107494	c.2165C>T	p.S722F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3642780	c.4866C>T	p.F1622F	Substitution - coding silent	Skin
COSM3883722	c.4317C>T	p.S1439S	Substitution - coding silent	Stomach
COSM5611044	c.3310G>A	p.E1104K	Substitution - Missense	Skin
COSM3929287	c.1825G>A	p.G609R	Substitution - Missense	Central_nervous_system
COSM5725737	c.4519C>T	p.P1507S	Substitution - Missense	Skin
COSM4503306	c.6318C>T	p.R2106R	Substitution - coding silent	Skin
COSM1230629	c.5C>T	p.A2V	Substitution - Missense	Large_intestine

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
24349473	Mutation	Splenic Marginal Zone Lymphoma	In additional to providing independent validation of the presence of mutation in several previously reported genes (NOTCH2, TNFAIP3, MAP3K14, MLL2 and SPEN), our study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A.
22237626	Mutation	Melanoma	Aim1 and Trrap mutations known to be altered in human melanoma were included among those found.

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9Y4A5	1628	S	Phosphoserine	-	No	None detected
Q9Y4A5	2051	S	Phosphoserine	-	Yes	p.S2051F (cancer: SKCM)
Q9Y4A5	2077	S	Phosphoserine	-	No	None detected
Q9Y4A5	3078	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.207	6.344	0.182	0.223	NS
BRCA	Breast invasive carcinoma	112	1100	6.642	6.707	0.095	0.0989	NS
CESC	Cervical and endocervical cancers	3	306	6.258	6.119	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.471	6.734	0.36	0.000297	NS
ESCA	Esophageal carcinoma	11	185	6.908	7.303	0.449	0.0613	NS
GBM	Glioblastoma multiforme	5	166	6.449	6.527	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.042	6.171	0.144	0.273	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.542	6.391	-0.114	0.0866	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.57	6.842	0.376	0.00171	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.005	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.728	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.963	5.221	0.196	0.0452	NS
LUAD	Lung adenocarcinoma	59	517	6.229	6.628	0.541	4.24e-08	NS
LUSC	Lung squamous cell carcinoma	51	501	6.299	6.628	0.341	0.00142	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.79	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.281	6.246	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.092	6.214	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.528	6.548	0.094	0.341	NS
READ	Rectum adenocarcinoma	10	167	6.438	6.794	0.502	0.0291	NS
SARC	Sarcoma	2	263	5.461	6.33	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.128	6.852	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.564	7.125	0.67	3.91e-08	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.489	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.774	6.688	0.009	0.896	NS
THYM	Thymoma	2	120	7.281	6.808	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.393	6.416	-0.028	0.815	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.8
Autonomic ganglia	CHP212	8.3
Autonomic ganglia	IMR32	9
Autonomic ganglia	KELLY	8.4
Autonomic ganglia	KPNRTBM1	8.2
Autonomic ganglia	KPNSI9S	8.6
Autonomic ganglia	KPNYN	7.9
Autonomic ganglia	MHHNB11	8.2
Autonomic ganglia	NB1	8.5
Autonomic ganglia	NH6	8
Autonomic ganglia	SHSY5Y	9.1
Autonomic ganglia	SIMA	8.8
Autonomic ganglia	SKNAS	8.1
Autonomic ganglia	SKNBE2	8
Autonomic ganglia	SKNDZ	8
Autonomic ganglia	SKNFI	8
Autonomic ganglia	SKNSH	8.3
Biliary tract	HUCCT1	7.5
Biliary tract	HUH28	7.1
Biliary tract	SNU1079	8.3
Biliary tract	SNU1196	8.6
Biliary tract	SNU245	8.7
Biliary tract	SNU308	8.2
Biliary tract	SNU478	8.9
Bone	143B	8.2
Bone	A673	8.3
Bone	CADOES1	8.5
Bone	CAL78	7.9
Bone	G292CLONEA141B1	7.5
Bone	HOS	8.2
Bone	HS706T	7.6
Bone	HS737T	7.1
Bone	HS819T	6.8
Bone	HS821T	7.8
Bone	HS822T	7
Bone	HS863T	7.7
Bone	HS870T	6.9
Bone	HS888T	8.3
Bone	MG63	7.4
Bone	MHHES1	8.1
Bone	OUMS27	8.7
Bone	RDES	8.8
Bone	SJSA1	7.8
Bone	SKES1	8.9
Bone	SKNMC	8.9
Bone	SW1353	8.5
Bone	T173	7.2
Bone	TC71	7.6
Bone	U2OS	9.6
Breast	AU565	8.3
Breast	BT20	7.9
Breast	BT474	8.6
Breast	BT483	9.2
Breast	BT549	8.3
Breast	CAL120	8
Breast	CAL148	10
Breast	CAL51	9.4
Breast	CAL851	7.5
Breast	CAMA1	7.9
Breast	DU4475	9
Breast	EFM192A	8.5
Breast	EFM19	7.3
Breast	EVSAT	9.5
Breast	HCC1143	7.3
Breast	HCC1187	9.1
Breast	HCC1395	8.5
Breast	HCC1419	7.9
Breast	HCC1428	8.4
Breast	HCC1500	8.2
Breast	HCC1569	8.1
Breast	HCC1599	8.2
Breast	HCC1806	7.6
Breast	HCC1937	7.1
Breast	HCC1954	7.9
Breast	HCC202	8.7
Breast	HCC2157	7.6
Breast	HCC2218	8.2
Breast	HCC38	8.1
Breast	HCC70	7.5
Breast	HDQP1	8.3
Breast	HMC18	8.8
Breast	HS274T	7.7
Breast	HS281T	7.9
Breast	HS343T	7.9
Breast	HS578T	7.9
Breast	HS606T	7.6
Breast	HS739T	7.4
Breast	HS742T	7.2
Breast	JIMT1	8.2
Breast	KPL1	9.2
Breast	MCF7	8.3
Breast	MDAMB134VI	7.6
Breast	MDAMB157	7.8
Breast	MDAMB175VII	7.9
Breast	MDAMB231	8.1
Breast	MDAMB361	7.9
Breast	MDAMB415	7.6
Breast	MDAMB436	8.7
Breast	MDAMB453	7.1
Breast	MDAMB468	7.6
Breast	SKBR3	8.5
Breast	T47D	7
Breast	UACC812	7.9
Breast	UACC893	8.1
Breast	YMB1	7.6
Breast	ZR751	6.9
Breast	ZR7530	7.8
Central nervous system	1321N1	8.1
Central nervous system	42MGBA	8
Central nervous system	8MGBA	7.1
Central nervous system	A172	7.9
Central nervous system	AM38	7.6
Central nervous system	BECKER	8.1
Central nervous system	CAS1	8.9
Central nervous system	CCFSTTG1	8.2
Central nervous system	D283MED	7.8
Central nervous system	D341MED	8.1
Central nervous system	DAOY	9.1
Central nervous system	DBTRG05MG	8.2
Central nervous system	DKMG	7.8
Central nervous system	GAMG	8.3
Central nervous system	GB1	8.4
Central nervous system	GI1	8.8
Central nervous system	GMS10	7.5
Central nervous system	GOS3	8.5
Central nervous system	H4	8.6
Central nervous system	HS683	8.4
Central nervous system	KALS1	7.7
Central nervous system	KG1C	8.3
Central nervous system	KNS42	8.8
Central nervous system	KNS60	7.4
Central nervous system	KNS81	8.4
Central nervous system	KS1	8.1
Central nervous system	LN18	9.1
Central nervous system	LN229	8.3
Central nervous system	M059K	7.8
Central nervous system	MOGGCCM	8.7
Central nervous system	MOGGUVW	8.1
Central nervous system	NMCG1	8.7
Central nervous system	ONS76	8.1
Central nervous system	SF126	8
Central nervous system	SF295	8.8
Central nervous system	SNB19	8.7
Central nervous system	SNU1105	9
Central nervous system	SNU201	8.7
Central nervous system	SNU466	9
Central nervous system	SNU489	9.1
Central nervous system	SNU626	9.1
Central nervous system	SNU738	8.4
Central nervous system	SW1088	9
Central nervous system	SW1783	8.3
Central nervous system	T98G	9.1
Central nervous system	TM31	8.8
Central nervous system	U118MG	8.7
Central nervous system	U138MG	8.7
Central nervous system	U251MG	8.7
Central nervous system	U87MG	8.1
Central nervous system	YH13	9.1
Central nervous system	YKG1	8.5
Endometrium	AN3CA	8.9
Endometrium	COLO684	9.8
Endometrium	EFE184	6.9
Endometrium	EN	7.4
Endometrium	ESS1	7.7
Endometrium	HEC108	8.2
Endometrium	HEC151	7.6
Endometrium	HEC1A	8.2
Endometrium	HEC1B	8.8
Endometrium	HEC251	7.7
Endometrium	HEC265	8.1
Endometrium	HEC50B	7.7
Endometrium	HEC59	8.5
Endometrium	HEC6	8.2
Endometrium	ISHIKAWAHERAKLIO02ER	7.8
Endometrium	JHUEM1	8.1
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	8.6
Endometrium	KLE	7.5
Endometrium	MFE280	8.5
Endometrium	MFE296	8.7
Endometrium	MFE319	7.8
Endometrium	RL952	8.2
Endometrium	SNGM	7.6
Endometrium	SNU1077	8.2
Endometrium	SNU685	9.1
Endometrium	TEN	8.8
Haematopoietic and lymphoid	697	9.1
Haematopoietic and lymphoid	A3KAW	8.4
Haematopoietic and lymphoid	A4FUK	9.2
Haematopoietic and lymphoid	ALLSIL	9.4
Haematopoietic and lymphoid	AML193	8.2
Haematopoietic and lymphoid	AMO1	9.4
Haematopoietic and lymphoid	BCP1	9.1
Haematopoietic and lymphoid	BDCM	8.4
Haematopoietic and lymphoid	BL41	10.1
Haematopoietic and lymphoid	BL70	9
Haematopoietic and lymphoid	BV173	8.7
Haematopoietic and lymphoid	CA46	9.8
Haematopoietic and lymphoid	CI1	8.5
Haematopoietic and lymphoid	CMK115	8.7
Haematopoietic and lymphoid	CMK86	9
Haematopoietic and lymphoid	CMK	8.8
Haematopoietic and lymphoid	CMLT1	9.4
Haematopoietic and lymphoid	COLO775	9.5
Haematopoietic and lymphoid	DAUDI	9
Haematopoietic and lymphoid	DB	9.1
Haematopoietic and lymphoid	DEL	8.5
Haematopoietic and lymphoid	DND41	9.4
Haematopoietic and lymphoid	DOHH2	9.7
Haematopoietic and lymphoid	EB1	8.3
Haematopoietic and lymphoid	EB2	8.7
Haematopoietic and lymphoid	EHEB	8.6
Haematopoietic and lymphoid	EJM	9.9
Haematopoietic and lymphoid	EM2	8.6
Haematopoietic and lymphoid	EOL1	8.5
Haematopoietic and lymphoid	F36P	8.6
Haematopoietic and lymphoid	GA10	8.6
Haematopoietic and lymphoid	GDM1	8.5
Haematopoietic and lymphoid	GRANTA519	9
Haematopoietic and lymphoid	HDLM2	8.4
Haematopoietic and lymphoid	HDMYZ	8
Haematopoietic and lymphoid	HEL9217	8.4
Haematopoietic and lymphoid	HEL	8.2
Haematopoietic and lymphoid	HH	8.5
Haematopoietic and lymphoid	HL60	8.4
Haematopoietic and lymphoid	HPBALL	10.1
Haematopoietic and lymphoid	HS604T	7.1
Haematopoietic and lymphoid	HS611T	8.4
Haematopoietic and lymphoid	HS616T	7.5
Haematopoietic and lymphoid	HS751T	6.6
Haematopoietic and lymphoid	HT	8.1
Haematopoietic and lymphoid	HTK	8.6
Haematopoietic and lymphoid	HUNS1	8
Haematopoietic and lymphoid	HUT102	7.7
Haematopoietic and lymphoid	HUT78	8.9
Haematopoietic and lymphoid	JEKO1	9.8
Haematopoietic and lymphoid	JK1	8.2
Haematopoietic and lymphoid	JM1	9.3
Haematopoietic and lymphoid	JURKAT	9
Haematopoietic and lymphoid	JURLMK1	8.5
Haematopoietic and lymphoid	JVM2	8
Haematopoietic and lymphoid	JVM3	8.9
Haematopoietic and lymphoid	K562	8.2
Haematopoietic and lymphoid	KARPAS299	8
Haematopoietic and lymphoid	KARPAS422	8.7
Haematopoietic and lymphoid	KARPAS620	9.2
Haematopoietic and lymphoid	KASUMI1	7.8
Haematopoietic and lymphoid	KASUMI2	9.5
Haematopoietic and lymphoid	KASUMI6	8.4
Haematopoietic and lymphoid	KCL22	8.4
Haematopoietic and lymphoid	KE37	9.6
Haematopoietic and lymphoid	KE97	8.1
Haematopoietic and lymphoid	KG1	7.5
Haematopoietic and lymphoid	KHM1B	8.1
Haematopoietic and lymphoid	KIJK	8.8
Haematopoietic and lymphoid	KMH2	8.7
Haematopoietic and lymphoid	KMM1	9.1
Haematopoietic and lymphoid	KMS11	9.9
Haematopoietic and lymphoid	KMS12BM	9.4
Haematopoietic and lymphoid	KMS18	8.8
Haematopoietic and lymphoid	KMS20	9.2
Haematopoietic and lymphoid	KMS21BM	8.3
Haematopoietic and lymphoid	KMS26	8.7
Haematopoietic and lymphoid	KMS27	8.5
Haematopoietic and lymphoid	KMS28BM	8.9
Haematopoietic and lymphoid	KMS34	9.4
Haematopoietic and lymphoid	KO52	7.3
Haematopoietic and lymphoid	KOPN8	9.3
Haematopoietic and lymphoid	KU812	8.2
Haematopoietic and lymphoid	KYO1	8.9
Haematopoietic and lymphoid	L1236	8.3
Haematopoietic and lymphoid	L363	9.3
Haematopoietic and lymphoid	L428	9.1
Haematopoietic and lymphoid	L540	9
Haematopoietic and lymphoid	LAMA84	7.9
Haematopoietic and lymphoid	LOUCY	8.8
Haematopoietic and lymphoid	LP1	9.8
Haematopoietic and lymphoid	M07E	8.5
Haematopoietic and lymphoid	MC116	8.3
Haematopoietic and lymphoid	ME1	9.1
Haematopoietic and lymphoid	MEC1	9.3
Haematopoietic and lymphoid	MEC2	8.9
Haematopoietic and lymphoid	MEG01	8
Haematopoietic and lymphoid	MHHCALL2	8.8
Haematopoietic and lymphoid	MHHCALL3	9.1
Haematopoietic and lymphoid	MHHCALL4	8.9
Haematopoietic and lymphoid	MINO	9.9
Haematopoietic and lymphoid	MJ	8.9
Haematopoietic and lymphoid	MM1S	8.7
Haematopoietic and lymphoid	MOLM13	8.2
Haematopoietic and lymphoid	MOLM16	9
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	10
Haematopoietic and lymphoid	MOLP8	8.7
Haematopoietic and lymphoid	MOLT13	9.6
Haematopoietic and lymphoid	MOLT16	9.4
Haematopoietic and lymphoid	MOLT4	9.1
Haematopoietic and lymphoid	MONOMAC1	8.5
Haematopoietic and lymphoid	MONOMAC6	9
Haematopoietic and lymphoid	MOTN1	9.2
Haematopoietic and lymphoid	MUTZ5	9
Haematopoietic and lymphoid	MV411	8.4
Haematopoietic and lymphoid	NALM19	9.1
Haematopoietic and lymphoid	NALM1	9.2
Haematopoietic and lymphoid	NALM6	9.5
Haematopoietic and lymphoid	NAMALWA	9.2
Haematopoietic and lymphoid	NB4	9.1
Haematopoietic and lymphoid	NCIH929	8.2
Haematopoietic and lymphoid	NCO2	7.9
Haematopoietic and lymphoid	NOMO1	9
Haematopoietic and lymphoid	NUDHL1	9.7
Haematopoietic and lymphoid	NUDUL1	9
Haematopoietic and lymphoid	OCIAML2	8.6
Haematopoietic and lymphoid	OCIAML3	9.6
Haematopoietic and lymphoid	OCIAML5	8.5
Haematopoietic and lymphoid	OCILY10	8.7
Haematopoietic and lymphoid	OCILY19	9.2
Haematopoietic and lymphoid	OCILY3	8.1
Haematopoietic and lymphoid	OCIM1	8.6
Haematopoietic and lymphoid	OPM2	8.4
Haematopoietic and lymphoid	P12ICHIKAWA	9.8
Haematopoietic and lymphoid	P31FUJ	8.4
Haematopoietic and lymphoid	P3HR1	8.2
Haematopoietic and lymphoid	PCM6	9.8
Haematopoietic and lymphoid	PEER	9.3
Haematopoietic and lymphoid	PF382	9.6
Haematopoietic and lymphoid	PFEIFFER	8.9
Haematopoietic and lymphoid	PL21	8.6
Haematopoietic and lymphoid	RAJI	8.4
Haematopoietic and lymphoid	RCHACV	9.4
Haematopoietic and lymphoid	REC1	9
Haematopoietic and lymphoid	REH	8.8
Haematopoietic and lymphoid	RI1	10.1
Haematopoietic and lymphoid	RL	8.9
Haematopoietic and lymphoid	RPMI8226	8.9
Haematopoietic and lymphoid	RPMI8402	9.2
Haematopoietic and lymphoid	RS411	8.9
Haematopoietic and lymphoid	SEM	8.4
Haematopoietic and lymphoid	SET2	8.9
Haematopoietic and lymphoid	SIGM5	8.8
Haematopoietic and lymphoid	SKM1	7.7
Haematopoietic and lymphoid	SKMM2	8.6
Haematopoietic and lymphoid	SR786	8
Haematopoietic and lymphoid	ST486	9
Haematopoietic and lymphoid	SUDHL10	9.5
Haematopoietic and lymphoid	SUDHL1	8.2
Haematopoietic and lymphoid	SUDHL4	9.5
Haematopoietic and lymphoid	SUDHL5	9
Haematopoietic and lymphoid	SUDHL6	9.8
Haematopoietic and lymphoid	SUDHL8	9.3
Haematopoietic and lymphoid	SUPB15	8.7
Haematopoietic and lymphoid	SUPHD1	8.9
Haematopoietic and lymphoid	SUPM2	7.7
Haematopoietic and lymphoid	SUPT11	9.4
Haematopoietic and lymphoid	SUPT1	9
Haematopoietic and lymphoid	TALL1	9.5
Haematopoietic and lymphoid	TF1	8.8
Haematopoietic and lymphoid	THP1	8.4
Haematopoietic and lymphoid	TO175T	7.5
Haematopoietic and lymphoid	TOLEDO	8.9
Haematopoietic and lymphoid	U266B1	9
Haematopoietic and lymphoid	U937	8.5
Haematopoietic and lymphoid	UT7	8.2
Haematopoietic and lymphoid	WSUDLCL2	8.7
Kidney	769P	8.2
Kidney	786O	8.4
Kidney	A498	8.9
Kidney	A704	6.6
Kidney	ACHN	8.7
Kidney	BFTC909	8.3
Kidney	CAKI1	7.6
Kidney	CAKI2	7.8
Kidney	CAL54	9.3
Kidney	KMRC1	7.4
Kidney	KMRC20	8.9
Kidney	KMRC2	7.7
Kidney	KMRC3	7
Kidney	OSRC2	8
Kidney	RCC10RGB	7.9
Kidney	SNU1272	7.7
Kidney	SNU349	7.9
Kidney	TUHR10TKB	8.6
Kidney	TUHR14TKB	8.8
Kidney	TUHR4TKB	8.1
Kidney	VMRCRCW	8.1
Kidney	VMRCRCZ	8.8
Large intestine	C2BBE1	8
Large intestine	CCK81	8.4
Large intestine	CL11	9.2
Large intestine	CL14	8.7
Large intestine	CL34	9.2
Large intestine	CL40	8.4
Large intestine	COLO205	7.5
Large intestine	COLO320	8.5
Large intestine	COLO678	8.9
Large intestine	CW2	9.3
Large intestine	DLD1	8.6
Large intestine	GP2D	7.9
Large intestine	HCC56	7.8
Large intestine	HCT116	8.7
Large intestine	HCT15	8.8
Large intestine	HS675T	7.4
Large intestine	HS698T	7.8
Large intestine	HT115	8.7
Large intestine	HT29	8.5
Large intestine	HT55	8.1
Large intestine	KM12	7.5
Large intestine	LOVO	8.6
Large intestine	LS1034	8.2
Large intestine	LS123	7.5
Large intestine	LS180	8.6
Large intestine	LS411N	9
Large intestine	LS513	7.3
Large intestine	MDST8	8.4
Large intestine	NCIH508	8.3
Large intestine	NCIH716	8.3
Large intestine	NCIH747	7.7
Large intestine	OUMS23	8.1
Large intestine	RCM1	7.8
Large intestine	RKO	7.9
Large intestine	SKCO1	9.1
Large intestine	SNU1040	8.8
Large intestine	SNU1197	8.2
Large intestine	SNU175	8.8
Large intestine	SNU283	8.7
Large intestine	SNU407	8.2
Large intestine	SNU503	8.3
Large intestine	SNU61	8.6
Large intestine	SNU81	8.4
Large intestine	SNUC1	8.7
Large intestine	SNUC2A	8.3
Large intestine	SNUC4	8.8
Large intestine	SNUC5	8.8
Large intestine	SW1116	7.6
Large intestine	SW1417	8.4
Large intestine	SW1463	8.2
Large intestine	SW403	8.2
Large intestine	SW480	8.8
Large intestine	SW48	9.1
Large intestine	SW620	8.6
Large intestine	SW837	7.1
Large intestine	SW948	8.7
Large intestine	T84	8.8
Liver	ALEXANDERCELLS	7.7
Liver	C3A	7.7
Liver	HEP3B217	8.2
Liver	HEPG2	8
Liver	HLE	7.2
Liver	HLF	6.9
Liver	HUH1	8
Liver	HUH6	8.7
Liver	HUH7	8.3
Liver	JHH1	7.9
Liver	JHH2	9.2
Liver	JHH4	7.7
Liver	JHH5	7.9
Liver	JHH6	7.6
Liver	JHH7	9
Liver	LI7	8.9
Liver	PLCPRF5	7.9
Liver	SKHEP1	7.4
Liver	SNU182	8
Liver	SNU387	7.8
Liver	SNU398	9
Liver	SNU423	8
Liver	SNU449	8.4
Liver	SNU475	8.3
Liver	SNU761	7.9
Liver	SNU878	7.5
Liver	SNU886	8.5
Lung	A549	7.8
Lung	ABC1	7.8
Lung	BEN	8.5
Lung	CAL12T	7.5
Lung	CALU1	8.2
Lung	CALU3	7.2
Lung	CALU6	8.7
Lung	CHAGOK1	6.9
Lung	COLO668	8.5
Lung	COLO699	9.3
Lung	CORL105	8.2
Lung	CORL23	8
Lung	CORL24	8.1
Lung	CORL279	8.9
Lung	CORL311	7.9
Lung	CORL47	7.5
Lung	CORL51	7.7
Lung	CORL88	7.8
Lung	CORL95	8
Lung	CPCN	8.2
Lung	DMS114	8.3
Lung	DMS153	8
Lung	DMS273	8.6
Lung	DMS454	7
Lung	DMS53	8.4
Lung	DMS79	8.5
Lung	DV90	7.9
Lung	EBC1	9.6
Lung	EPLC272H	9.2
Lung	HARA	8.4
Lung	HCC1171	9
Lung	HCC1195	8.7
Lung	HCC15	7.9
Lung	HCC2279	7.3
Lung	HCC2935	8.8
Lung	HCC33	9.2
Lung	HCC366	7.6
Lung	HCC4006	8
Lung	HCC44	7.9
Lung	HCC78	8.3
Lung	HCC827	8.6
Lung	HCC95	7.1
Lung	HLC1	9.5
Lung	HLFA	7.5
Lung	HS229T	7.5
Lung	HS618T	7.7
Lung	IALM	8.5
Lung	KNS62	8.1
Lung	LC1F	8.3
Lung	LC1SQSF	7.3
Lung	LCLC103H	8.7
Lung	LCLC97TM1	9.1
Lung	LK2	8.5
Lung	LOUNH91	8.5
Lung	LU65	8.2
Lung	LU99	7.2
Lung	LUDLU1	8.4
Lung	LXF289	8.6
Lung	MORCPR	8
Lung	NCIH1048	8.3
Lung	NCIH1092	8.3
Lung	NCIH1105	8.1
Lung	NCIH1155	8.2
Lung	NCIH1184	8.4
Lung	NCIH1299	9
Lung	NCIH1339	6.9
Lung	NCIH1341	8.9
Lung	NCIH1355	7.7
Lung	NCIH1373	8.2
Lung	NCIH1385	8.7
Lung	NCIH1395	7.2
Lung	NCIH1435	8.3
Lung	NCIH1436	7.9
Lung	NCIH1437	7.9
Lung	NCIH146	8.4
Lung	NCIH1563	7.6
Lung	NCIH1568	9
Lung	NCIH1573	8.4
Lung	NCIH1581	9.2
Lung	NCIH1618	8.4
Lung	NCIH1623	8.2
Lung	NCIH1648	8
Lung	NCIH1650	7.9
Lung	NCIH1651	7.9
Lung	NCIH1666	7.5
Lung	NCIH1693	6.9
Lung	NCIH1694	8.6
Lung	NCIH1703	9.2
Lung	NCIH1734	7.9
Lung	NCIH1755	8.5
Lung	NCIH1781	8.2
Lung	NCIH1792	8.6
Lung	NCIH1793	8.3
Lung	NCIH1836	8.3
Lung	NCIH1838	8.2
Lung	NCIH1869	8.2
Lung	NCIH1876	7.9
Lung	NCIH1915	6.7
Lung	NCIH1930	8.6
Lung	NCIH1944	7.4
Lung	NCIH1963	8.6
Lung	NCIH196	8.2
Lung	NCIH1975	8.5
Lung	NCIH2009	8.3
Lung	NCIH2023	7.7
Lung	NCIH2029	8.4
Lung	NCIH2030	8.4
Lung	NCIH2066	8.3
Lung	NCIH2081	7.7
Lung	NCIH2085	8.4
Lung	NCIH2087	8.3
Lung	NCIH209	8.4
Lung	NCIH2106	8.6
Lung	NCIH2110	6.9
Lung	NCIH211	8.8
Lung	NCIH2122	8.4
Lung	NCIH2126	8.6
Lung	NCIH2141	8.5
Lung	NCIH2170	8.9
Lung	NCIH2171	8.7
Lung	NCIH2172	7.1
Lung	NCIH2196	8.5
Lung	NCIH2227	8.7
Lung	NCIH2228	7
Lung	NCIH226	7.7
Lung	NCIH2286	7.8
Lung	NCIH2291	8.4
Lung	NCIH2342	8.2
Lung	NCIH2347	6.8
Lung	NCIH23	8.6
Lung	NCIH2405	8.5
Lung	NCIH2444	8.5
Lung	NCIH292	8.1
Lung	NCIH322	8.8
Lung	NCIH3255	9.4
Lung	NCIH358	7.9
Lung	NCIH441	8.7
Lung	NCIH446	7.8
Lung	NCIH460	8.2
Lung	NCIH510	8.2
Lung	NCIH520	7.9
Lung	NCIH522	9
Lung	NCIH524	8.3
Lung	NCIH526	8.7
Lung	NCIH596	6.7
Lung	NCIH647	8.2
Lung	NCIH650	8.5
Lung	NCIH661	8.3
Lung	NCIH69	8.1
Lung	NCIH727	8.3
Lung	NCIH810	8.7
Lung	NCIH82	8.5
Lung	NCIH838	7
Lung	NCIH841	9.3
Lung	NCIH854	8.3
Lung	NCIH889	8.5
Lung	PC14	8.1
Lung	RERFLCAD1	8
Lung	RERFLCAD2	6.4
Lung	RERFLCAI	7.9
Lung	RERFLCKJ	8.3
Lung	RERFLCMS	7.9
Lung	RERFLCSQ1	8.6
Lung	SBC5	9.2
Lung	SCLC21H	8.8
Lung	SHP77	7.8
Lung	SKLU1	8.1
Lung	SKMES1	6.9
Lung	SQ1	7.6
Lung	SW1271	8.5
Lung	SW1573	8.2
Lung	SW900	8
Lung	VMRCLCD	8.9
Lung	VMRCLCP	8.5
Oesophagus	COLO680N	8
Oesophagus	ECGI10	8.3
Oesophagus	KYSE140	8.5
Oesophagus	KYSE150	7.7
Oesophagus	KYSE180	8.6
Oesophagus	KYSE270	7.6
Oesophagus	KYSE30	8.3
Oesophagus	KYSE410	8.8
Oesophagus	KYSE450	8.4
Oesophagus	KYSE510	7.9
Oesophagus	KYSE520	7.9
Oesophagus	KYSE70	8.2
Oesophagus	OE19	8.6
Oesophagus	OE33	8.7
Oesophagus	TE10	8.3
Oesophagus	TE11	7.3
Oesophagus	TE14	8.5
Oesophagus	TE15	6.9
Oesophagus	TE1	8.1
Oesophagus	TE4	8.2
Oesophagus	TE5	9.1
Oesophagus	TE6	8.6
Oesophagus	TE8	7.8
Oesophagus	TE9	7.8
Oesophagus	TT	7.7
Ovary	59M	6.7
Ovary	A2780	8.9
Ovary	CAOV3	8.1
Ovary	CAOV4	8
Ovary	COLO704	9.4
Ovary	COV318	8.4
Ovary	COV362	6.9
Ovary	COV434	7.6
Ovary	COV504	8.2
Ovary	COV644	8.1
Ovary	EFO21	8.7
Ovary	EFO27	8
Ovary	ES2	7.4
Ovary	FUOV1	7.8
Ovary	HEYA8	6.5
Ovary	HS571T	7.2
Ovary	IGROV1	8.6
Ovary	JHOC5	8.5
Ovary	JHOM1	7.4
Ovary	JHOM2B	8.9
Ovary	JHOS2	6.3
Ovary	JHOS4	7.3
Ovary	KURAMOCHI	8.9
Ovary	MCAS	8.3
Ovary	NIHOVCAR3	7.8
Ovary	OAW28	7.2
Ovary	OAW42	8.6
Ovary	OC314	8.3
Ovary	OC316	8.1
Ovary	ONCODG1	8.7
Ovary	OV56	6.9
Ovary	OV7	7.9
Ovary	OV90	9.1
Ovary	OVCAR4	8.7
Ovary	OVCAR8	7.1
Ovary	OVISE	7.2
Ovary	OVK18	8.9
Ovary	OVKATE	7.4
Ovary	OVMANA	7.2
Ovary	OVSAHO	8.2
Ovary	OVTOKO	7
Ovary	RMGI	7.2
Ovary	RMUGS	6.8
Ovary	SKOV3	7.4
Ovary	SNU119	8.7
Ovary	SNU840	8.5
Ovary	SNU8	8.3
Ovary	TOV112D	8.8
Ovary	TOV21G	7.6
Ovary	TYKNU	8.5
Pancreas	ASPC1	11.3
Pancreas	BXPC3	8
Pancreas	CAPAN1	8.9
Pancreas	CAPAN2	7.9
Pancreas	CFPAC1	7.3
Pancreas	DANG	8.5
Pancreas	HPAC	8.3
Pancreas	HPAFII	7.8
Pancreas	HS766T	8.1
Pancreas	HUPT3	7.9
Pancreas	HUPT4	7.9
Pancreas	KCIMOH1	7.5
Pancreas	KLM1	9.2
Pancreas	KP2	7.9
Pancreas	KP3	6.8
Pancreas	KP4	8.8
Pancreas	L33	8.2
Pancreas	MIAPACA2	8.8
Pancreas	PANC0203	7.8
Pancreas	PANC0213	8.4
Pancreas	PANC0327	7.9
Pancreas	PANC0403	7.4
Pancreas	PANC0504	8
Pancreas	PANC0813	7.4
Pancreas	PANC1005	8.5
Pancreas	PANC1	7.7
Pancreas	PATU8902	6.8
Pancreas	PATU8988S	8
Pancreas	PATU8988T	8.3
Pancreas	PK1	7.5
Pancreas	PK45H	8.1
Pancreas	PK59	8
Pancreas	PL45	8.1
Pancreas	PSN1	8.1
Pancreas	QGP1	8.3
Pancreas	SNU213	10
Pancreas	SNU324	9.1
Pancreas	SNU410	8.9
Pancreas	SU8686	8
Pancreas	SUIT2	7.3
Pancreas	SW1990	7.3
Pancreas	T3M4	6.8
Pancreas	TCCPAN2	7.4
Pancreas	YAPC	8.1
Pleura	ACCMESO1	6.9
Pleura	DM3	7.9
Pleura	ISTMES1	8.5
Pleura	ISTMES2	8.1
Pleura	JL1	9.3
Pleura	MPP89	7
Pleura	MSTO211H	8.2
Pleura	NCIH2052	7.4
Pleura	NCIH2452	7.7
Pleura	NCIH28	8.1
Prostate	22RV1	8.5
Prostate	DU145	7.1
Prostate	LNCAPCLONEFGC	7.8
Prostate	MDAPCA2B	8.6
Prostate	NCIH660	7.3
Prostate	PC3	8.2
Prostate	VCAP	8.6
Salivary gland	A253	7.5
Salivary gland	YD15	7.8
Skin	A101D	8.1
Skin	A2058	9.2
Skin	A375	8.2
Skin	C32	9.3
Skin	CHL1	8.8
Skin	CJM	7.9
Skin	COLO679	9.1
Skin	COLO741	8.1
Skin	COLO783	7.7
Skin	COLO792	7.8
Skin	COLO800	8.1
Skin	COLO818	8.4
Skin	COLO829	8.5
Skin	COLO849	8.6
Skin	G361	9
Skin	GRM	9
Skin	HMCB	9.3
Skin	HS294T	8.4
Skin	HS600T	7.3
Skin	HS688AT	7.4
Skin	HS695T	8.8
Skin	HS839T	7.2
Skin	HS852T	8
Skin	HS895T	6.7
Skin	HS934T	7.9
Skin	HS936T	8
Skin	HS939T	8.3
Skin	HS940T	7.7
Skin	HS944T	7.8
Skin	HT144	8.2
Skin	IGR1	8.2
Skin	IGR37	8.8
Skin	IGR39	8.4
Skin	IPC298	8
Skin	K029AX	8.7
Skin	LOXIMVI	7.8
Skin	MALME3M	8.3
Skin	MDAMB435S	6.7
Skin	MELHO	8.7
Skin	MELJUSO	7.8
Skin	MEWO	8.1
Skin	RPMI7951	7.4
Skin	RVH421	8.1
Skin	SH4	8.5
Skin	SKMEL1	7.9
Skin	SKMEL24	8.6
Skin	SKMEL28	8
Skin	SKMEL2	8.2
Skin	SKMEL30	7.6
Skin	SKMEL31	8.6
Skin	SKMEL3	8.5
Skin	SKMEL5	8.4
Skin	UACC257	8
Skin	UACC62	8.2
Skin	WM115	8.6
Skin	WM1799	7.6
Skin	WM2664	8.7
Skin	WM793	8.3
Skin	WM88	7.7
Skin	WM983B	7
Small intestine	HUTU80	8.3
Soft tissue	A204	7.9
Soft tissue	G401	8.9
Soft tissue	G402	8.5
Soft tissue	GCT	7.6
Soft tissue	HS729	7.5
Soft tissue	HT1080	8.2
Soft tissue	KYM1	8.6
Soft tissue	MESSA	8.4
Soft tissue	RD	8.9
Soft tissue	RH30	9
Soft tissue	RH41	9.2
Soft tissue	RKN	7.7
Soft tissue	S117	8.1
Soft tissue	SJRH30	8.6
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	8.4
Soft tissue	TE125T	7.1
Soft tissue	TE159T	7.7
Soft tissue	TE441T	9
Soft tissue	TE617T	8.3
Stomach	2313287	7.9
Stomach	AGS	8.3
Stomach	AZ521	8.7
Stomach	ECC10	9.1
Stomach	ECC12	8.5
Stomach	FU97	8.3
Stomach	GCIY	8.6
Stomach	GSS	8.5
Stomach	GSU	8.9
Stomach	HGC27	8.2
Stomach	HS746T	9.5
Stomach	HUG1N	8.3
Stomach	IM95	8.6
Stomach	KATOIII	8.2
Stomach	KE39	8.5
Stomach	LMSU	7.9
Stomach	MKN1	8.1
Stomach	MKN45	9.1
Stomach	MKN74	7.8
Stomach	MKN7	7.5
Stomach	NCCSTCK140	7.3
Stomach	NCIN87	8.4
Stomach	NUGC2	8.2
Stomach	NUGC3	7.7
Stomach	NUGC4	8.3
Stomach	OCUM1	8.4
Stomach	RERFGC1B	8.5
Stomach	SH10TC	8.1
Stomach	SNU16	8.4
Stomach	SNU1	8.5
Stomach	SNU216	9
Stomach	SNU520	9
Stomach	SNU5	9.7
Stomach	SNU601	9.1
Stomach	SNU620	8.7
Stomach	SNU668	8.7
Stomach	SNU719	9.4
Stomach	TGBC11TKB	8.6
Thyroid	8305C	8.7
Thyroid	8505C	7.8
Thyroid	BCPAP	7.8
Thyroid	BHT101	8.9
Thyroid	CAL62	8.9
Thyroid	CGTHW1	8.2
Thyroid	FTC133	8.3
Thyroid	FTC238	7.7
Thyroid	ML1	9
Thyroid	SW579	7.5
Thyroid	TT2609C02	8.9
Thyroid	TT	8.5
Upper aerodigestive tract	BHY	8.1
Upper aerodigestive tract	BICR16	8.6
Upper aerodigestive tract	BICR18	8.7
Upper aerodigestive tract	BICR22	7
Upper aerodigestive tract	BICR31	6.5
Upper aerodigestive tract	BICR56	7.5
Upper aerodigestive tract	BICR6	7.4
Upper aerodigestive tract	CAL27	8
Upper aerodigestive tract	CAL33	8.2
Upper aerodigestive tract	DETROIT562	8.5
Upper aerodigestive tract	FADU	8.2
Upper aerodigestive tract	HS840T	7.6
Upper aerodigestive tract	HSC2	7.6
Upper aerodigestive tract	HSC3	6.6
Upper aerodigestive tract	HSC4	8.7
Upper aerodigestive tract	PECAPJ15	8.5
Upper aerodigestive tract	PECAPJ34CLONEC12	7.1
Upper aerodigestive tract	PECAPJ41CLONED2	7
Upper aerodigestive tract	PECAPJ49	7.6
Upper aerodigestive tract	SCC15	7.3
Upper aerodigestive tract	SCC25	7.4
Upper aerodigestive tract	SCC4	9.3
Upper aerodigestive tract	SCC9	8
Upper aerodigestive tract	SNU1076	7.1
Upper aerodigestive tract	SNU1214	7.6
Upper aerodigestive tract	SNU46	8.1
Upper aerodigestive tract	SNU899	8.3
Upper aerodigestive tract	YD10B	7.9
Upper aerodigestive tract	YD38	7.7
Upper aerodigestive tract	YD8	8.3
Urinary tract	5637	8.7
Urinary tract	639V	9.1
Urinary tract	647V	8.4
Urinary tract	BC3C	7.7
Urinary tract	BFTC905	8
Urinary tract	CAL29	9.5
Urinary tract	HS172T	7.3
Urinary tract	HT1197	6.7
Urinary tract	HT1376	8.2
Urinary tract	J82	7.5
Urinary tract	JMSU1	8.1
Urinary tract	KMBC2	8
Urinary tract	KU1919	7.8
Urinary tract	RT11284	7.7
Urinary tract	RT112	8
Urinary tract	RT4	8.2
Urinary tract	SCABER	6.8
Urinary tract	SW1710	8.6
Urinary tract	SW780	7.8
Urinary tract	T24	7.9
Urinary tract	TCCSUP	8.3
Urinary tract	UMUC1	8.3
Urinary tract	UMUC3	8.6
Urinary tract	VMCUB1	9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	6.2
Adrenal gland	7.5
Appendix	11.4
Bone marrow	8.2
Breast	7.8
Cerebral cortex	9.5
Cervix, uterine	10.3
Colon	6.5
Duodenum	6.5
Endometrium	11.7
Epididymis	6.3
Esophagus	5.3
Fallopian tube	14.9
Gallbladder	8.9
Heart muscle	4
Kidney	5.8
Liver	2.4
Lung	8.4
Lymph node	13.7
Ovary	15.2
Pancreas	1.9
Parathyroid gland	22.2
Placenta	9.8
Prostate	9.9
Rectum	6.2
Salivary gland	3.2
Seminal vesicle	8.3
Skeletal muscle	2.2
Skin	13.2
Small intestine	7.3
Smooth muscle	10.1
Spleen	11.4
Stomach	5.9
Testis	21.2
Thyroid gland	15.3
Tonsil	9.5
Urinary bladder	7.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27066097	Underexpression	Breast Carcinoma	The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%).

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.482	7.6e-25	7.9	55	37.1	Gain
BRCA	Breast invasive carcinoma	1075	0.394	2.88e-41	12.8	59.3	27.9	Neutral
CESC	Cervical and endocervical cancers	292	0.363	1.65e-10	12.7	71.9	15.4	Neutral
COAD	Colon adenocarcinoma	449	0.354	1.11e-14	1.1	49.2	49.7	Gain
ESCA	Esophageal carcinoma	183	0.687	6.5e-27	10.9	31.1	57.9	Gain
GBM	Glioblastoma multiforme	147	0.428	6.58e-08	0	16.3	83.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.5	7.75e-34	7	60.1	32.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.268	4.58e-10	0.4	66.7	33	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.486	1.82e-18	0.3	39.2	60.4	Gain
LAML	Acute Myeloid Leukemia	166	0.305	6.28e-05	10.2	89.8	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.459	4.49e-28	0.6	67.6	31.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.325	2.15e-10	7.7	59.9	32.4	Neutral
LUAD	Lung adenocarcinoma	512	0.425	6.99e-24	10.5	47.1	42.4	Gain
LUSC	Lung squamous cell carcinoma	498	0.428	1.44e-23	8	41	51	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.539	4.84e-24	15.7	43.7	40.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.574	7.12e-17	2.8	67.2	29.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.518	1.63e-12	4.9	82.1	13	Neutral
PRAD	Prostate adenocarcinoma	491	0.274	6.35e-10	1.4	78	20.6	Neutral
READ	Rectum adenocarcinoma	164	0.384	3.89e-07	1.8	46.3	51.8	Gain
SARC	Sarcoma	255	0.474	1.14e-15	16.1	55.7	28.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.658	6.79e-47	6.3	38.7	55	Gain
STAD	Stomach adenocarcinoma	413	0.649	1.03e-50	7.5	47	45.5	Gain
TGCT	Testicular Germ Cell Tumors	150	0.576	1.21e-14	2.7	23.3	74	Gain
THCA	Thyroid carcinoma	497	0.108	0.0162	0.2	95.8	4	Neutral
THYM	Thymoma	119	0.028	0.762	1.7	84.9	13.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.36	6.74e-18	6.9	76.7	16.4	Neutral

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.128	0.00833	17	408	-0.102	1.06e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.211	3.51e-10	83	785	-0.059	9.84e-10	NS/NA
CESC	Cervical and endocervical cancers	-0.228	5.45e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.199	0.000388	19	297	0.001	0.169	NS/NA
ESCA	Esophageal carcinoma	-0.418	1.96e-09	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.195	0.12	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.28	4.15e-11	20	522	0.002	6e-04	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.107	0.0485	24	319	0.003	0.209	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.263	4.68e-06	23	275	0.001	0.37	NS/NA
LAML	Acute Myeloid Leukemia	-0.192	0.0124	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.137	0.00155	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.138	0.00488	41	373	-0.019	0.000122	NS/NA
LUAD	Lung adenocarcinoma	-0.143	0.00179	21	456	-0.002	0.226	NS/NA
LUSC	Lung squamous cell carcinoma	-0.264	2.08e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.75	0.0255	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.305	2.99e-05	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.182	0.0129	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.155	0.000336	35	498	0.001	0.0592	NS/NA
READ	Rectum adenocarcinoma	-0.356	0.000287	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.248	4.95e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.304	1.89e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.284	2.78e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.36	4.71e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.106	0.0122	50	509	-0.001	0.757	NS/NA
THYM	Thymoma	-0.09	0.322	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.093	0.0459	34	431	0.013	5.55e-05	NS/NA

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.865	NS	24476821
BRCA	Breast invasive carcinoma	521	1.28e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0292	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00806	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	6.92e-09	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	4.75e-05	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.00186	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.12	NS	25079552
LUSC	Lung squamous cell carcinoma	178	9.16e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000836	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0295	Significant	26544944
READ	Rectum adenocarcinoma	67	0.103	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0314	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0222	Significant	25079317
THCA	Thyroid carcinoma	391	0.00026	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00153	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.124	0.569	NS
BRCA	Breast invasive carcinoma	1079	1.335	0.243	NS
CESC	Cervical and endocervical cancers	291	2.304	0.0234	Shorter
COAD	Colon adenocarcinoma	439	1.133	0.699	NS
ESCA	Esophageal carcinoma	184	0.825	0.544	NS
GBM	Glioblastoma multiforme	158	1.249	0.37	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.006	0.975	NS
KIRC	Kidney renal clear cell carcinoma	531	0.76	0.199	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.92	0.847	NS
LAML	Acute Myeloid Leukemia	149	0.516	0.0315	Longer
LGG	Brain Lower Grade Glioma	511	2.108	0.00683	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.2	0.416	NS
LUAD	Lung adenocarcinoma	502	1.009	0.965	NS
LUSC	Lung squamous cell carcinoma	494	0.819	0.311	NS
OV	Ovarian serous cystadenocarcinoma	303	1.29	0.228	NS
PAAD	Pancreatic adenocarcinoma	177	0.796	0.444	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.986	0.32	NS
PRAD	Prostate adenocarcinoma	497	0.911	0.941	NS
READ	Rectum adenocarcinoma	159	0.65	0.466	NS
SARC	Sarcoma	259	1.247	0.451	NS
SKCM	Skin Cutaneous Melanoma	459	1.436	0.0684	NS
STAD	Stomach adenocarcinoma	388	0.824	0.412	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.326	NS
THCA	Thyroid carcinoma	500	1.261	0.761	NS
THYM	Thymoma	119	0	0.0532	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.568	0.143	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.015	0.767	NS
BRCA	Breast invasive carcinoma	1071	0.016	0.61	NS
CESC	Cervical and endocervical cancers	167	0.056	0.476	NS
COAD	Colon adenocarcinoma	445	0.031	0.51	NS
ESCA	Esophageal carcinoma	162	-0.047	0.549	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.016	0.733	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.082	0.0593	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.096	0.122	NS
LIHC	Liver hepatocellular carcinoma	347	0.12	0.0256	Higher
LUAD	Lung adenocarcinoma	507	0.099	0.0265	Higher
LUSC	Lung squamous cell carcinoma	497	0.041	0.359	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.051	0.382	NS
PAAD	Pancreatic adenocarcinoma	176	-0.045	0.556	NS
READ	Rectum adenocarcinoma	156	0.002	0.983	NS
SKCM	Skin Cutaneous Melanoma	410	0.037	0.459	NS
STAD	Stomach adenocarcinoma	392	0.052	0.304	NS
TGCT	Testicular Germ Cell Tumors	81	-0.004	0.973	NS
THCA	Thyroid carcinoma	499	-0.022	0.62	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.053	0.24	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.027	0.656	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.121	0.00676	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.01	0.818	NS
LGG	Brain Lower Grade Glioma	514	0.064	0.148	NS
LIHC	Liver hepatocellular carcinoma	366	0.102	0.0511	NS
OV	Ovarian serous cystadenocarcinoma	296	0.076	0.191	NS
PAAD	Pancreatic adenocarcinoma	176	0.004	0.954	NS
STAD	Stomach adenocarcinoma	406	-0.033	0.502	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.179	3.11e-05	Higher

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TRRAP.

Summary
Symbol	TRRAP
Name	transformation/transcription domain associated protein
Aliases	PAF400; PAF350/400; STAF40; 350/400 kDa PCAF-associated factor; tra1 homolog
Location	7q22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for TRRAP.