CR2Cancer

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00628 PHD-finger
PF02182 SAD/SRA domain
PF12148 Tandem tudor domain within UHRF1
PF00240 Ubiquitin family

Function

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read, Histone modification write cofactor	Histone ubiquitination, #	H3K9me3, H3R2, H3, mCG	H3ub	17967883

> Gene Ontology [ TOP ]
Biological Process	GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006513 protein monoubiquitination GO:0010216 maintenance of DNA methylation GO:0010390 histone monoubiquitination GO:0010911 regulation of isomerase activity GO:0010912 positive regulation of isomerase activity GO:0016458 gene silencing GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0031935 regulation of chromatin silencing GO:0032781 positive regulation of ATPase activity GO:0040029 regulation of gene expression, epigenetic GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043462 regulation of ATPase activity GO:0045814 negative regulation of gene expression, epigenetic GO:0051052 regulation of DNA metabolic process GO:0051865 protein autoubiquitination GO:0060968 regulation of gene silencing GO:0090308 regulation of methylation-dependent chromatin silencing GO:1902275 regulation of chromatin organization GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Molecular Function	GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0004842 ubiquitin-protein transferase activity GO:0008327 methyl-CpG binding GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031491 nucleosome binding GO:0031493 nucleosomal histone binding GO:0035064 methylated histone binding GO:0042393 histone binding GO:0044729 hemi-methylated DNA-binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0005657 replication fork GO:0005720 nuclear heterochromatin GO:0016363 nuclear matrix GO:0034399 nuclear periphery GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5334118: DNA methylation R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record for UHRF1.

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1318281	c.861G>T	p.V287V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5573633	c.1428G>T	p.A476A	Substitution - coding silent	Prostate
COSM5505427	c.1344+9A>T	p.?	Unknown	Biliary_tract
COSM4970092	c.2078G>A	p.S693N	Substitution - Missense	Central_nervous_system
COSM5967801	c.1279C>T	p.P427S	Substitution - Missense	Upper_aerodigestive_tract
COSM3712996	c.466G>T	p.A156S	Substitution - Missense	Upper_aerodigestive_tract
COSM4831891	c.252C>A	p.L84L	Substitution - coding silent	Liver
COSM5722793	c.1536G>A	p.Q512Q	Substitution - coding silent	Skin
COSM4447676	c.1879G>A	p.A627T	Substitution - Missense	Skin
COSM1394330	c.2014_2015insC	p.P674fs*35	Insertion - Frameshift	Central_nervous_system
COSM999179	c.1731C>T	p.Y577Y	Substitution - coding silent	Endometrium
COSM5961662	c.251T>G	p.L84R	Substitution - Missense	Adrenal_gland
COSM4831891	c.252C>A	p.L84L	Substitution - coding silent	Liver
COSM999147	c.923G>T	p.R308I	Substitution - Missense	Endometrium
COSM1645106	c.577G>A	p.E193K	Substitution - Missense	Salivary_gland
COSM4079926	c.760G>A	p.A254T	Substitution - Missense	Stomach
COSM5056812	c.1255C>T	p.R419C	Substitution - Missense	Stomach
COSM3766400	c.1704C>T	p.Y568Y	Substitution - coding silent	Liver
COSM4746553	c.1920_1922delGGA	p.E644delE	Deletion - In frame	Stomach
COSM4285224	c.2016G>C	p.A672A	Substitution - coding silent	Soft_tissue
COSM999145	c.849G>T	p.R283R	Substitution - coding silent	Endometrium
COSM999079	c.385G>A	p.E129K	Substitution - Missense	Endometrium
COSM3536728	c.2165C>T	p.P722L	Substitution - Missense	Skin
COSM3108304	c.1428G>A	p.A476A	Substitution - coding silent	Large_intestine
COSM1231707	c.1023C>G	p.D341E	Substitution - Missense	Large_intestine
COSM4448225	c.2022C>T	p.P674P	Substitution - coding silent	Skin
COSM5593852	c.1097C>T	p.P366L	Substitution - Missense	Skin
COSM999208	c.2356G>A	p.V786M	Substitution - Missense	Endometrium
COSM4739132	c.865G>A	p.E289K	Substitution - Missense	Large_intestine
COSM4827486	c.1422C>A	p.V474V	Substitution - coding silent	Cervix
COSM1394330	c.2014_2015insC	p.P674fs*35	Insertion - Frameshift	Central_nervous_system
COSM4079956	c.1453C>G	p.H485D	Substitution - Missense	Stomach
COSM999077	c.382G>A	p.A128T	Substitution - Missense	Endometrium
COSM5365703	c.7G>T	p.V3F	Substitution - Missense	Large_intestine
COSM4079928	c.798G>A	p.R266R	Substitution - coding silent	Stomach
COSM4447923	c.2001T>A	p.G667G	Substitution - coding silent	Skin
COSM713512	c.743G>A	p.R248Q	Substitution - Missense	Lung
COSM1325213	c.1344+2T>C	p.?	Unknown	Ovary
COSM6003464	c.2068G>A	p.A690T	Substitution - Missense	Prostate
COSM5722793	c.1536G>A	p.Q512Q	Substitution - coding silent	Skin
COSM3835335	c.1526C>G	p.S509C	Substitution - Missense	Breast
COSM4412184	c.271G>A	p.V91M	Substitution - Missense	Oesophagus
COSM3378798	c.1737C>T	p.P579P	Substitution - coding silent	Pancreas
COSM4000811	c.31G>T	p.A11S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3712996	c.466G>T	p.A156S	Substitution - Missense	Upper_aerodigestive_tract
COSM6004048	c.1143C>T	p.S381S	Substitution - coding silent	Prostate
COSM475008	c.1748A>G	p.K583R	Substitution - Missense	Kidney
COSM3536662	c.210C>T	p.T70T	Substitution - coding silent	Skin
COSM999075	c.293A>C	p.E98A	Substitution - Missense	Endometrium
COSM95426	c.967A>T	p.N323Y	Substitution - Missense	Lung
COSM1129764	c.1622G>A	p.R541Q	Substitution - Missense	Prostate
COSM4448298	c.536G>A	p.R179Q	Substitution - Missense	Skin
COSM5440261	c.2106C>T	p.N702N	Substitution - coding silent	Oesophagus
COSM1660113	c.992G>A	p.C331Y	Substitution - Missense	Kidney
COSM5390281	c.2246C>T	p.T749I	Substitution - Missense	Skin
COSM5038377	c.372T>C	p.G124G	Substitution - coding silent	Skin
COSM5722793	c.1536G>A	p.Q512Q	Substitution - coding silent	Skin
COSM4448188	c.1303C>T	p.P435S	Substitution - Missense	Skin
COSM5695582	c.313G>T	p.D105Y	Substitution - Missense	Soft_tissue
COSM4969812	c.2216_2217delGT	p.C739fs*>67	Deletion - Frameshift	Central_nervous_system
COSM4079922	c.577G>C	p.E193Q	Substitution - Missense	Stomach
COSM5973067	c.837G>T	p.L279L	Substitution - coding silent	Upper_aerodigestive_tract
COSM128435	c.696G>T	p.V232V	Substitution - coding silent	Upper_aerodigestive_tract
COSM3389196	c.652C>A	p.R218R	Substitution - coding silent	Pancreas
COSM475011	c.1972G>T	p.G658C	Substitution - Missense	Kidney
COSM4079947	c.882G>A	p.E294E	Substitution - coding silent	Stomach
COSM1394330	c.2014_2015insC	p.P674fs*35	Insertion - Frameshift	Central_nervous_system
COSM3389196	c.652C>A	p.R218R	Substitution - coding silent	Pancreas
COSM4079952	c.1331G>A	p.R444Q	Substitution - Missense	Stomach
COSM4079916	c.250C>A	p.L84I	Substitution - Missense	Stomach
COSM5056813	c.1530T>C	p.C510C	Substitution - coding silent	Stomach
COSM4393615	c.554C>G	p.S185C	Substitution - Missense	Prostate
COSM3107997	c.395G>A	p.S132N	Substitution - Missense	Large_intestine
COSM4447421	c.2022_2022+1CC>TT	p.?	Unknown	Skin
COSM3960268	c.1430G>T	p.G477V	Substitution - Missense	Lung
COSM999088	c.781G>A	p.E261K	Substitution - Missense	Endometrium
COSM712048	c.379G>T	p.A127S	Substitution - Missense	Lung
COSM1394303	c.659G>C	p.R220P	Substitution - Missense	Large_intestine
COSM1394330	c.2014_2015insC	p.P674fs*35	Insertion - Frameshift	Central_nervous_system
COSM4000812	c.66C>T	p.D22D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1304865	c.147C>T	p.F49F	Substitution - coding silent	Urinary_tract
COSM439934	c.829G>T	p.D277Y	Substitution - Missense	Breast
COSM359239	c.1741A>T	p.K581*	Substitution - Nonsense	Lung
COSM3766399	c.1386A>C	p.I462I	Substitution - coding silent	Liver
COSM4448189	c.1371C>T	p.P457P	Substitution - coding silent	Skin
COSM4285224	c.2016G>C	p.A672A	Substitution - coding silent	Pancreas
COSM5048610	c.855C>T	p.I285I	Substitution - coding silent	Oesophagus
COSM3536709	c.1287C>T	p.N429N	Substitution - coding silent	Skin
COSM4901755	c.228C>T	p.V76V	Substitution - coding silent	Skin
COSM4831891	c.252C>A	p.L84L	Substitution - coding silent	Cervix
COSM4000811	c.31G>T	p.A11S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3536702	c.902C>T	p.P301L	Substitution - Missense	Skin
COSM3835343	c.2178C>A	p.F726L	Substitution - Missense	Breast
COSM3108199	c.840C>T	p.N280N	Substitution - coding silent	Oesophagus
COSM4448490	c.1230G>A	p.W410*	Substitution - Nonsense	Skin
COSM6004049	c.1515C>T	p.T505T	Substitution - coding silent	Prostate
COSM4447849	c.371G>A	p.G124D	Substitution - Missense	Skin
COSM1231708	c.62T>C	p.M21T	Substitution - Missense	Large_intestine
COSM5573678	c.246C>T	p.I82I	Substitution - coding silent	Prostate
COSM4897096	c.477G>A	p.T159T	Substitution - coding silent	Skin
COSM5722793	c.1536G>A	p.Q512Q	Substitution - coding silent	Skin
COSM1304887	c.1108G>C	p.E370Q	Substitution - Missense	Urinary_tract
COSM1304889	c.1217C>G	p.S406*	Substitution - Nonsense	Urinary_tract
COSM5779931	c.1890C>G	p.N630K	Substitution - Missense	Breast
COSM4433846	c.216C>T	p.F72F	Substitution - coding silent	Oesophagus
COSM4878496	c.318C>T	p.T106T	Substitution - coding silent	Prostate
COSM331054	c.2068G>T	p.A690S	Substitution - Missense	Lung
COSM1304864	c.135C>A	p.I45I	Substitution - coding silent	Urinary_tract
COSM4079972	c.2150C>T	p.P717L	Substitution - Missense	Stomach
COSM1394330	c.2014_2015insC	p.P674fs*35	Insertion - Frameshift	Central_nervous_system
COSM5673603	c.731A>G	p.N244S	Substitution - Missense	Soft_tissue
COSM296142	c.2360A>C	p.N787T	Substitution - Missense	Large_intestine
COSM1645107	c.505G>A	p.V169M	Substitution - Missense	Salivary_gland
COSM4448225	c.2022C>T	p.P674P	Substitution - coding silent	Skin
COSM5038377	c.372T>C	p.G124G	Substitution - coding silent	Skin
COSM1189780	c.412G>T	p.D138Y	Substitution - Missense	Lung
COSM4403288	c.383C>T	p.A128V	Substitution - Missense	Skin
COSM130067	c.14C>T	p.A5V	Substitution - Missense	Upper_aerodigestive_tract
COSM999077	c.382G>A	p.A128T	Substitution - Missense	Stomach
COSM4079921	c.451A>G	p.N151D	Substitution - Missense	Stomach
COSM4079927	c.791C>A	p.T264K	Substitution - Missense	Stomach
COSM1235310	c.1_193-7069del11307	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4079957	c.1543A>T	p.T515S	Substitution - Missense	Stomach
COSM4448362	c.302_303CC>TT	p.S101F	Substitution - Missense	Skin
COSM439947	c.2209A>G	p.I737V	Substitution - Missense	Breast
COSM5779885	c.1720-8C>G	p.?	Unknown	Breast
COSM5779931	c.1890C>G	p.N630K	Substitution - Missense	Breast
COSM5045735	c.2335G>T	p.G779C	Substitution - Missense	Oesophagus
COSM4850451	c.1789G>A	p.D597N	Substitution - Missense	Cervix
COSM5650230	c.1216T>G	p.S406A	Substitution - Missense	Oesophagus
COSM5779885	c.1720-8C>G	p.?	Unknown	Breast
COSM95427	c.1467C>G	p.F489L	Substitution - Missense	Lung
COSM5771948	c.198G>A	p.E66E	Substitution - coding silent	Breast
COSM3536573	c.154G>A	p.E52K	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for UHRF1.

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q96T88	91	S	Phosphoserine	-	No	None detected
Q96T88	95	S	Phosphoserine	-	No	None detected
Q96T88	165	S	Phosphoserine	-	No	None detected
Q96T88	287	S	Phosphoserine	-	No	None detected
Q96T88	298	S	Phosphoserine	PKA	No	None detected
Q96T88	368	S	Phosphoserine	-	No	None detected
Q96T88	399	K	N6-acetyllysine	-	No	None detected
Q96T88	546	K	N6-acetyllysine	-	No	None detected
Q96T88	639	S	Phosphoserine	CDK1	No	None detected
Q96T88	651	S	Phosphoserine	-	No	None detected
Q96T88	707	S	Phosphoserine	-	No	None detected
Q96T88	709	S	Phosphoserine	-	No	None detected

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	1.194	4.828	3.627	1.21e-34	Over
BRCA	Breast invasive carcinoma	112	1100	0.411	4.29	3.883	6.32e-157	Over
CESC	Cervical and endocervical cancers	3	306	-1.292	5.892	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.754	5.013	2.292	3.6e-48	Over
ESCA	Esophageal carcinoma	11	185	1.085	4.627	3.274	2.75e-21	Over
GBM	Glioblastoma multiforme	5	166	0.332	4.697	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.327	4.741	1.862	3.13e-35	Over
KIRC	Kidney renal clear cell carcinoma	72	534	-1.621	1.879	3.33	9.06e-81	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	-1.619	1.439	2.965	3.18e-30	Over
LAML	Acute Myeloid Leukemia	0	173	NA	5.754	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.743	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-1.745	1.753	3.494	1.16e-37	Over
LUAD	Lung adenocarcinoma	59	517	0.11	3.777	3.427	8.77e-66	Over
LUSC	Lung squamous cell carcinoma	51	501	0.285	4.749	4.386	4.39e-125	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.171	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	2.274	3.049	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-1.029	-0.237	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.034	0.977	1.278	1.61e-11	Over
READ	Rectum adenocarcinoma	10	167	2.861	4.949	2.207	1.59e-10	Over
SARC	Sarcoma	2	263	0.142	4.267	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.302	4.158	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	2.608	4.177	2.534	6.53e-27	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.395	NA	NA	NA
THCA	Thyroid carcinoma	59	509	-1.602	1.302	2.379	8.36e-31	Over
THYM	Thymoma	2	120	6.51	6.597	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-0.264	5.049	4.819	4.4e-88	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	1.2
Adrenal gland	0.7
Appendix	13.3
Bone marrow	17.5
Breast	2.2
Cerebral cortex	10.4
Cervix, uterine	0.8
Colon	2.9
Duodenum	3.9
Endometrium	1.8
Epididymis	0.4
Esophagus	3.8
Fallopian tube	0.7
Gallbladder	1.4
Heart muscle	0.1
Kidney	0.2
Liver	0.5
Lung	1.2
Lymph node	19
Ovary	0.2
Pancreas	0.1
Parathyroid gland	0.7
Placenta	3
Prostate	0.7
Rectum	3
Salivary gland	0.3
Seminal vesicle	0.3
Skeletal muscle	0.4
Skin	4
Small intestine	4.5
Smooth muscle	2.7
Spleen	4.4
Stomach	3.3
Testis	10
Thyroid gland	0.6
Tonsil	10.3
Urinary bladder	2.8

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26497117	Overexpression	Pancreatic Carcinoma	UHRF1 expression was observed in 20% (5 of 25) of benign pancreatic ducts compared to 86% (114 of 132) of pancreatic tumours, and an inverse relationship between UHRF1 and Keap1 levels in PDAC tumours (n = 124) was apparent (p = 0.002).
26464697	Overexpression	Hepatocellular Carcinoma	The UHRF1 was over-expressed in HCC tissues compared with the adjacent normal tissues according to the outcome of HPLC (P<0.001).
26161699	Overexpression	Gastric Carcinoma	UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p<0.001) and have associations with age and lymph node metastasis (LNM).
26147747	Overexpression	Gastric Carcinoma	The results demonstrated that UHRF1 overexpression was an independent and significant predictor of GC prognosis.
26102039	Overexpression	Renal Cell Carcinoma	In this study, we found UHRF1 is frequently overexpressed in human clear cell Renal Cell Carcinoma (ccRCC) tissues both at mRNA and protein levels.
26070868	Overexpression	Ovarian Carcinoma	Our results demonstrated that both UHRF1 mRNA and protein were highly expressed in ovarian cancer tissues and significantly higher than that in adjacent normal tissues.
25641194	altered expression	Hepatocellular Carcinoma	A negative correlation of MEG3 and UHRF1 expression was verified in primary HCC tissues.
25430639	Overexpression	Hepatocellular Carcinoma	Notably, UHRF1 and Sp1 levels were elevated in subgroups of hepatocellular carcinoma patients and inversely correlated with TRα1 expression.
25416862	Overexpression	Pancreatic Carcinoma	In this study, it was found that the expression of UHRF1 was significantly up-regulated in pancreatic cancer samples compared to their adjacent normal tissues.
25272010	Overexpression	Bladder Carcinoma	We found that UHRF1 levels are upregulated in most clinical specimens of bladder cancer when compared with paired normal tissues, and UHRF1 expression levels are significantly increased in primary tumors that subsequently metastasized compared with non-metastatic tumors.
23943380	Overexpression	Oesophagal Squamous Cell Carcinoma	The results showed that UHRF1 was significantly overexpressed in ESCC specimens.
23107467	Overexpression	Breast Carcinoma	The UHRF1 DNA in plasma of 229 breast cancer patients showed higher expression than healthy controls, which showed high specificity up to 76.2% at a sensitivity of 79.2%, and was significantly associated with c-erbB2 positive status, cancer stage and lymph node metastasis.
23023523	Overexpression	Colorectal Carcinoma	High UHRF1 expression was observed in 152 of 231 (65.8%) colorectal cancer patients, and was detected in 35 of 40 adenoma specimens samples (87.5%).
22330138	Overexpression	Prostate Carcinoma	Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases.
21611839	Overexpression	Bladder Carcinoma	The UHRF1 expression rate was 49.2% in a total of 118 bladder cancer tissues, which was significantly higher than in normal tissues, and UHRF1 expression has a significantly positive correlation with tumor grade (P = 0.027) and recurrence (P = 0.013).
20613874	Underexpression	Glioma	Our results reveal that the disruption of Dnmt1/PCNA/UHRF1 interactions acts as an oncogenic event and that one of its signatures (i.e. the low level of mMTase activity) is a molecular biomarker associated with a poor prognosis in GBM patients.
20517312	Overexpression	Non-Small Cell Lung Cancer	In 322 Japanese non-small cell lung cancer (NSCLC) cases, UHRF1 expression was associated with the histological type (higher in non-ADCs; P<0.00001), gender (higher in male; P=0.00082), smoking (higher in smokers; P=0.00004), pT factor (higher in advanced stage; P=0.00010), and pN factor (higher in cancers with metastasis in regional lymph nodes; P=0.00018).
19491893	Overexpression	Bladder Carcinoma	Significant overexpression of UHRF1 was observed in bladder cancer.
28467809	Overexpression	Retinoblastoma	In this study, we show that UHRF1 is highly expressed in retinoblastoma, and genomes of human primary retinoblastoma and cell lines have differential DNA methylation patterns compared with those of normal retina, characterized by lower global methylation and higher promoter methylation of tumor suppressors.
26695082	Overexpression	Lung Carcinoma	This study attempts to identify differentially expressed genes (DEGs) related to lung adenocarcinoma in Xuanwei. The tendency of changes in the expression of 12 selected DEGs (five downregulated genes, PIK3R1, RARB, HGF, MAPK11, and SESN1, and seven upregulated genes, PAK1, E2F1, CCNE1, EGF, CDC25A, PTTG1, and UHRF1) in RTq-PCR was consistent with the expression profiling data.

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.074	0.139	33.9	51	15.1	Loss
BRCA	Breast invasive carcinoma	1075	0.114	0.000183	26.7	58.4	14.9	Neutral
CESC	Cervical and endocervical cancers	292	0.386	7.92e-12	34.2	55.1	10.6	Loss
COAD	Colon adenocarcinoma	449	0.157	0.000832	12.9	71.9	15.1	Neutral
ESCA	Esophageal carcinoma	183	0.166	0.0248	47.5	41	11.5	Loss
GBM	Glioblastoma multiforme	147	0.32	7.88e-05	8.2	55.8	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.337	4.36e-15	29.2	61.5	9.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.094	0.0318	3	88.2	8.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.03	0.61	7.3	91	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.011	0.89	2.4	94	3.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.323	6.23e-14	4.1	73.3	22.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.038	0.474	23.4	62.9	13.7	Neutral
LUAD	Lung adenocarcinoma	512	0.052	0.237	53.3	43.4	3.3	Loss
LUSC	Lung squamous cell carcinoma	498	0.293	2.64e-11	40.8	40.6	18.7	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.281	7.81e-07	73.7	14	12.3	Loss
PAAD	Pancreatic adenocarcinoma	177	-0.311	2.56e-05	18.1	75.1	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.248	0.00144	0.6	84	15.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.086	0.0577	6.7	91.4	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.359	2.41e-06	20.7	61	18.3	Neutral
SARC	Sarcoma	255	0.181	0.00373	13.7	48.6	37.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.196	0.000163	24.8	58.6	16.6	Neutral
STAD	Stomach adenocarcinoma	413	0.126	0.0105	35.6	57.6	6.8	Loss
TGCT	Testicular Germ Cell Tumors	150	-0.169	0.0382	31.3	44	24.7	Neutral
THCA	Thyroid carcinoma	497	0.162	0.000299	1.6	97	1.4	Neutral
THYM	Thymoma	119	-0.063	0.497	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.263	5.8e-10	25.5	70.8	3.7	Neutral

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.483	0	17	408	-0.108	1.86e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.399	0	83	785	-0.063	5.96e-31	NS/NA
CESC	Cervical and endocervical cancers	-0.31	2.97e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.395	3.78e-13	19	297	-0.148	1.74e-13	NS/NA
ESCA	Esophageal carcinoma	-0.125	0.0836	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.556	2.34e-06	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.251	3.34e-09	20	522	-0.101	8.39e-06	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.227	2.25e-05	24	319	-0.027	2.36e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.185	0.00134	23	275	-0.015	0.063	NS/NA
LAML	Acute Myeloid Leukemia	-0.313	3.52e-05	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.267	4.85e-10	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.459	0	41	373	-0.054	1.7e-14	NS/NA
LUAD	Lung adenocarcinoma	-0.407	0	21	456	-0.087	6.64e-09	NS/NA
LUSC	Lung squamous cell carcinoma	-0.244	1.72e-06	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.9	0.00203	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.492	0	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.119	0.104	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.319	6.55e-14	35	498	-0.016	0.0397	NS/NA
READ	Rectum adenocarcinoma	-0.278	0.00497	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.25	4.33e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.378	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.281	4.06e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.23	0.00392	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.278	2.93e-11	50	509	-0.016	1.25e-09	NS/NA
THYM	Thymoma	-0.541	9.69e-11	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.417	0	34	431	-0.043	0.00113	NS/NA

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.707	NS	24476821
BRCA	Breast invasive carcinoma	521	3.34e-35	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00602	Significant	22810696
GBM	Glioblastoma multiforme	157	1.39e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0055	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.595	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.0582	NS	26824661
LUAD	Lung adenocarcinoma	230	3.41e-17	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00112	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000151	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.678	NS	26544944
READ	Rectum adenocarcinoma	67	0.525	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.195	NS	26091043
STAD	Stomach adenocarcinoma	277	1.13e-12	Significant	25079317
THCA	Thyroid carcinoma	391	1.08e-14	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.21e-07	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.075	0.737	NS
BRCA	Breast invasive carcinoma	1079	1.096	0.679	NS
CESC	Cervical and endocervical cancers	291	0.538	0.0442	Longer
COAD	Colon adenocarcinoma	439	0.836	0.489	NS
ESCA	Esophageal carcinoma	184	1.093	0.802	NS
GBM	Glioblastoma multiforme	158	0.868	0.58	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.78	0.211	NS
KIRC	Kidney renal clear cell carcinoma	531	2.605	4.12e-06	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	3.805	0.000492	Shorter
LAML	Acute Myeloid Leukemia	149	0.599	0.0855	NS
LGG	Brain Lower Grade Glioma	511	1.828	0.0175	Shorter
LIHC	Liver hepatocellular carcinoma	365	2.068	0.00316	Shorter
LUAD	Lung adenocarcinoma	502	2.251	0.000154	Shorter
LUSC	Lung squamous cell carcinoma	494	0.644	0.0196	Longer
OV	Ovarian serous cystadenocarcinoma	303	1.084	0.702	NS
PAAD	Pancreatic adenocarcinoma	177	2.94	0.000396	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	3.036	0.312	NS
PRAD	Prostate adenocarcinoma	497	4.692	0.12	NS
READ	Rectum adenocarcinoma	159	0.487	0.28	NS
SARC	Sarcoma	259	2.647	0.000572	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.299	0.153	NS
STAD	Stomach adenocarcinoma	388	0.445	0.000808	Longer
TGCT	Testicular Germ Cell Tumors	134	0.63	0.743	NS
THCA	Thyroid carcinoma	500	0.464	0.266	NS
THYM	Thymoma	119	0	0.00827	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.598	0.081	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.043	0.383	NS
BRCA	Breast invasive carcinoma	1071	0.035	0.257	NS
CESC	Cervical and endocervical cancers	167	-0.008	0.917	NS
COAD	Colon adenocarcinoma	445	-0.165	0.000476	Lower
ESCA	Esophageal carcinoma	162	-0.041	0.6	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.007	0.883	NS
KIRC	Kidney renal clear cell carcinoma	531	0.28	5.12e-11	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.362	1.9e-09	Higher
LIHC	Liver hepatocellular carcinoma	347	0.173	0.00125	Higher
LUAD	Lung adenocarcinoma	507	0.188	2.07e-05	Higher
LUSC	Lung squamous cell carcinoma	497	0.114	0.0112	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.134	0.0197	Lower
PAAD	Pancreatic adenocarcinoma	176	0.029	0.705	NS
READ	Rectum adenocarcinoma	156	-0.168	0.0364	Lower
SKCM	Skin Cutaneous Melanoma	410	-0.131	0.00813	Lower
STAD	Stomach adenocarcinoma	392	-0.058	0.25	NS
TGCT	Testicular Germ Cell Tumors	81	0.384	0.000395	Higher
THCA	Thyroid carcinoma	499	-0.025	0.577	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.054	0.226	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.07	0.248	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.226	3.41e-07	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.291	1.06e-11	Higher
LGG	Brain Lower Grade Glioma	514	0.134	0.00232	Higher
LIHC	Liver hepatocellular carcinoma	366	0.298	6e-09	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.036	0.54	NS
PAAD	Pancreatic adenocarcinoma	176	0.204	0.00673	Higher
STAD	Stomach adenocarcinoma	406	-0.007	0.896	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.008	0.858	NS

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for UHRF1.

Summary
Symbol	UHRF1
Name	ubiquitin like with PHD and ring finger domains 1
Aliases	Np95; FLJ21925; RNF106; TDRD22; hNP95; hUHRF1; huNp95; RING finger protein 106; inverted CCAAT box-binding p ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26102039	Renal Cell Carcinoma	partner	p53	Interaction	We showed that UHRF1 directly interacts with p53 both in vivo and in vitro.
25641194	Hepatocellular Carcinoma	downstream	MEG3	Negative regulation	Down-regulation of UHRF1 induced MEG3 expression in HCC cell lines, which could be reversed by the up-regulation of UHRF1.
25430639	Hepatocellular Carcinoma	partner	TRα1	Negative Correlation	Notably, UHRF1 and Sp1 levels were elevated in subgroups of hepatocellular carcinoma patients and inversely correlated with TRα1 expression.
20613874	Glioma	partner	PCNA; Dnmt1	Interaction	Our results reveal that the disruption of Dnmt1/PCNA/UHRF1 interactions acts as an oncogenic event and that one of its signatures (i.e. the low level of mMTase activity) is a molecular biomarker associated with a poor prognosis in GBM patients.