CR2Cancer

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00628 PHD-finger
PF02182 SAD/SRA domain
PF12148 Tandem tudor domain within UHRF1
PF00240 Ubiquitin family

Function

E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9me3, mCG	#	15361834

> Gene Ontology [ TOP ]
Biological Process	GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0007050 cell cycle arrest GO:0010216 maintenance of DNA methylation GO:0016458 gene silencing GO:0031935 regulation of chromatin silencing GO:0040029 regulation of gene expression, epigenetic GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045814 negative regulation of gene expression, epigenetic GO:0051052 regulation of DNA metabolic process GO:0051865 protein autoubiquitination GO:0060968 regulation of gene silencing GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0090068 positive regulation of cell cycle process GO:0090308 regulation of methylation-dependent chromatin silencing GO:1902275 regulation of chromatin organization
Molecular Function	GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0042393 histone binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0005720 nuclear heterochromatin GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1664886	c.2039C>T	p.A680V	Substitution - Missense	Kidney
COSM1109528	c.962G>A	p.G321E	Substitution - Missense	Endometrium
COSM4876862	c.2247C>T	p.F749F	Substitution - coding silent	Prostate
COSM5420838	c.583A>G	p.T195A	Substitution - Missense	Prostate
COSM4749315	c.2152G>C	p.V718L	Substitution - Missense	Stomach
COSM5359148	c.1605-8delT	p.?	Unknown	Large_intestine
COSM32661	c.1392+3A>G	p.?	Unknown	Large_intestine
COSM5998626	c.567G>T	p.L189F	Substitution - Missense	Prostate
COSM5423657	c.2137G>C	p.V713L	Substitution - Missense	Prostate
COSM95428	c.2196G>C	p.M732I	Substitution - Missense	Ovary
COSM5823090	c.1307C>G	p.T436R	Substitution - Missense	Liver
COSM3907606	c.1820G>A	p.R607H	Substitution - Missense	Stomach
COSM1109529	c.1182T>C	p.T394T	Substitution - coding silent	Endometrium
COSM462388	c.251C>G	p.S84C	Substitution - Missense	Cervix
COSM1735131	c.178G>T	p.D60Y	Substitution - Missense	Pancreas
COSM5467723	c.245G>A	p.G82D	Substitution - Missense	Large_intestine
COSM487505	c.230C>G	p.P77R	Substitution - Missense	Kidney
COSM2777758	c.874G>T	p.G292*	Substitution - Nonsense	Large_intestine
COSM3907605	c.1422T>C	p.H474H	Substitution - coding silent	Stomach
COSM4437080	c.335C>G	p.S112C	Substitution - Missense	Oesophagus
COSM1109523	c.191G>A	p.G64E	Substitution - Missense	Endometrium
COSM5998626	c.567G>T	p.L189F	Substitution - Missense	Prostate
COSM5698597	c.1377G>T	p.W459C	Substitution - Missense	Soft_tissue
COSM5977266	c.1752T>G	p.Y584*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1109531	c.1389T>C	p.V463V	Substitution - coding silent	Endometrium
COSM5423657	c.2137G>C	p.V713L	Substitution - Missense	Prostate
COSM487504	c.176T>C	p.F59S	Substitution - Missense	Kidney
COSM3848645	c.316G>C	p.G106R	Substitution - Missense	Breast
COSM4795603	c.1488G>A	p.A496A	Substitution - coding silent	Liver
COSM5903732	c.645-6C>T	p.?	Unknown	Skin
COSM1462672	c.71C>T	p.T24M	Substitution - Missense	Large_intestine
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Prostate
COSM1109533	c.2036A>C	p.K679T	Substitution - Missense	Endometrium
COSM4516762	c.2279_2280CC>TT	p.S760F	Substitution - Missense	Skin
COSM1462675	c.1277delG	p.G427fs*39	Deletion - Frameshift	Large_intestine
COSM1231713	c.1115A>G	p.Y372C	Substitution - Missense	Large_intestine
COSM5880141	c.2163+7G>A	p.?	Unknown	Skin
COSM1109524	c.216A>T	p.L72L	Substitution - coding silent	Endometrium
COSM1109525	c.368G>A	p.G123D	Substitution - Missense	Endometrium
COSM4654505	c.952T>A	p.F318I	Substitution - Missense	Large_intestine
COSM1462677	c.1879C>T	p.R627W	Substitution - Missense	Large_intestine
COSM1462677	c.1879C>T	p.R627W	Substitution - Missense	Stomach
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Large_intestine
COSM5359725	c.974-1G>C	p.?	Unknown	Large_intestine
COSM1462674	c.915C>T	p.I305I	Substitution - coding silent	Large_intestine
COSM3848646	c.1128A>C	p.P376P	Substitution - coding silent	Breast
COSM4945433	c.2332A>G	p.N778D	Substitution - Missense	Liver
COSM5447859	c.1497+2T>C	p.?	Unknown	Large_intestine
COSM4431025	c.2267G>A	p.C756Y	Substitution - Missense	Oesophagus
COSM366713	c.1076A>G	p.Q359R	Substitution - Missense	Lung
COSM1109530	c.1311A>C	p.R437S	Substitution - Missense	Endometrium
COSM4163947	c.1479T>G	p.G493G	Substitution - coding silent	Thyroid
COSM3953223	c.81G>C	p.E27D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM487506	c.848T>A	p.V283E	Substitution - Missense	Kidney
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Large_intestine
COSM1636200	c.2222A>C	p.Y741S	Substitution - Missense	Liver
COSM4795603	c.1488G>A	p.A496A	Substitution - coding silent	Liver
COSM1497043	c.154-2A>T	p.?	Unknown	Kidney
COSM5962857	c.353G>A	p.R118H	Substitution - Missense	Breast
COSM1109526	c.439C>T	p.H147Y	Substitution - Missense	Endometrium
COSM4739146	c.1307C>T	p.T436M	Substitution - Missense	Large_intestine
COSM4919770	c.1527A>G	p.G509G	Substitution - coding silent	Liver
COSM1497043	c.154-2A>T	p.?	Unknown	Kidney
COSM1109535	c.2403A>G	p.G801G	Substitution - coding silent	Endometrium
COSM4804628	c.643G>T	p.E215*	Substitution - Nonsense	Liver
COSM1109522	c.53A>G	p.D18G	Substitution - Missense	Endometrium
COSM5998226	c.1880G>A	p.R627Q	Substitution - Missense	Prostate
COSM4828805	c.619G>A	p.V207I	Substitution - Missense	Cervix
COSM3907603	c.876A>T	p.G292G	Substitution - coding silent	Stomach
COSM2777758	c.874G>T	p.G292*	Substitution - Nonsense	Large_intestine
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Prostate
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Prostate
COSM1462673	c.695G>A	p.R232Q	Substitution - Missense	Stomach
COSM1109534	c.2195T>C	p.M732T	Substitution - Missense	Endometrium
COSM3657729	c.858C>T	p.F286F	Substitution - coding silent	Skin
COSM4636534	c.121G>C	p.E41Q	Substitution - Missense	Large_intestine
COSM1109521	c.26A>G	p.D9G	Substitution - Missense	Endometrium
COSM5998226	c.1880G>A	p.R627Q	Substitution - Missense	Prostate
COSM5086195	c.2170C>T	p.L724L	Substitution - coding silent	Large_intestine
COSM4416110	c.2268C>T	p.C756C	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5962428	c.102G>T	p.A34A	Substitution - coding silent	Breast
COSM1462676	c.1697G>A	p.R566H	Substitution - Missense	Large_intestine
COSM4609463	c.1586C>A	p.T529K	Substitution - Missense	Adrenal_gland
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Prostate
COSM5153042	c.2281T>G	p.F761V	Substitution - Missense	Large_intestine
COSM1269733	c.2338A>G	p.I780V	Substitution - Missense	Oesophagus
COSM5359725	c.974-1G>C	p.?	Unknown	Large_intestine
COSM4804589	c.621T>C	p.V207V	Substitution - coding silent	Liver
COSM5553637	c.1867G>A	p.E623K	Substitution - Missense	Prostate
COSM1636199	c.1696C>T	p.R566C	Substitution - Missense	Liver
COSM1462674	c.915C>T	p.I305I	Substitution - coding silent	Oesophagus
COSM364822	c.1767+1G>T	p.?	Unknown	Lung
COSM1231712	c.2276G>A	p.R759H	Substitution - Missense	Large_intestine
COSM1462673	c.695G>A	p.R232Q	Substitution - Missense	Large_intestine
COSM5568119	c.1031C>G	p.S344C	Substitution - Missense	Prostate
COSM4804628	c.643G>T	p.E215*	Substitution - Nonsense	Liver
COSM33010	c.260T>A	p.I87N	Substitution - Missense	Large_intestine
COSM3953224	c.100G>A	p.A34T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3413686	c.11A>G	p.Q4R	Substitution - Missense	Central_nervous_system
COSM4739145	c.673A>G	p.N225D	Substitution - Missense	Large_intestine
COSM4804589	c.621T>C	p.V207V	Substitution - coding silent	Liver
COSM2777774	c.1923C>T	p.Y641Y	Substitution - coding silent	Large_intestine
COSM294928	c.1106A>T	p.Y369F	Substitution - Missense	Large_intestine
COSM5191946	c.92G>A	p.R31Q	Substitution - Missense	Large_intestine
COSM4163947	c.1479T>G	p.G493G	Substitution - coding silent	Oesophagus
COSM5115534	c.1285-9G>A	p.?	Unknown	Large_intestine
COSM4163947	c.1479T>G	p.G493G	Substitution - coding silent	Thyroid
COSM5136784	c.1067C>A	p.P356H	Substitution - Missense	Large_intestine
COSM4533064	c.1944G>A	p.K648K	Substitution - coding silent	Skin
COSM462387	c.584C>T	p.T195M	Substitution - Missense	Cervix
COSM5880141	c.2163+7G>A	p.?	Unknown	Skin
COSM4776587	c.1604+1G>A	p.?	Unknown	Breast
COSM3737955	c.2315G>A	p.R772Q	Substitution - Missense	Soft_tissue
COSM3724078	c.2204G>T	p.C735F	Substitution - Missense	Upper_aerodigestive_tract
COSM4884330	c.79G>A	p.E27K	Substitution - Missense	Upper_aerodigestive_tract
COSM5884869	c.1399G>A	p.E467K	Substitution - Missense	Breast
COSM1579331	c.2020G>T	p.A674S	Substitution - Missense	Fallopian_tube
COSM2777774	c.1923C>T	p.Y641Y	Substitution - coding silent	Large_intestine
COSM4171895	c.1230A>C	p.K410N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4441850	c.190G>T	p.G64*	Substitution - Nonsense	Large_intestine
COSM4649340	c.351C>T	p.A117A	Substitution - coding silent	Large_intestine
COSM754387	c.807C>A	p.T269T	Substitution - coding silent	Lung
COSM5153041	c.2271A>G	p.L757L	Substitution - coding silent	Large_intestine
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Stomach
COSM3907604	c.1378A>T	p.R460*	Substitution - Nonsense	Stomach
COSM5024617	c.1668G>C	p.W556C	Substitution - Missense	Large_intestine
COSM5789965	c.1411C>A	p.H471N	Substitution - Missense	Breast
COSM5011974	c.221G>A	p.R74H	Substitution - Missense	Kidney
COSM1231711	c.721G>T	p.E241*	Substitution - Nonsense	Large_intestine
COSM298862	c.731T>C	p.V244A	Substitution - Missense	Large_intestine
COSM5983511	c.226G>A	p.D76N	Substitution - Missense	Upper_aerodigestive_tract
COSM4163947	c.1479T>G	p.G493G	Substitution - coding silent	Thyroid
COSM1109532	c.1901G>A	p.R634H	Substitution - Missense	Endometrium
COSM3907607	c.2199C>T	p.C733C	Substitution - coding silent	Prostate
COSM5411137	c.2022C>T	p.A674A	Substitution - coding silent	Skin
COSM5955662	c.1379G>A	p.R460K	Substitution - Missense	Upper_aerodigestive_tract
COSM1109527	c.618C>T	p.D206D	Substitution - coding silent	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for UHRF2.

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.976	5.087	0.002	0.992	NS
BRCA	Breast invasive carcinoma	112	1100	5.469	5.191	-0.207	9.83e-05	NS
CESC	Cervical and endocervical cancers	3	306	5.527	5.446	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.738	5.136	0.425	6.1e-07	NS
ESCA	Esophageal carcinoma	11	185	5.482	5.231	-0.024	0.923	NS
GBM	Glioblastoma multiforme	5	166	5.013	5.014	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.285	4.757	0.591	1.16e-06	Over
KIRC	Kidney renal clear cell carcinoma	72	534	4.689	4.964	0.244	0.000203	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.514	4.594	0.058	0.539	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.401	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.864	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.718	3.78	0.142	0.124	NS
LUAD	Lung adenocarcinoma	59	517	4.662	4.939	0.27	0.00222	NS
LUSC	Lung squamous cell carcinoma	51	501	4.675	4.957	0.324	0.000553	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.916	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.203	5.107	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.894	4.361	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.524	5.359	-0.24	0.00233	NS
READ	Rectum adenocarcinoma	10	167	4.775	5.103	0.308	0.134	NS
SARC	Sarcoma	2	263	4.852	5.29	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.538	4.68	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.615	4.973	0.299	0.0152	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.489	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.991	4.916	-0.124	0.0103	NS
THYM	Thymoma	2	120	6.288	5.589	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.341	4.821	-0.577	8.57e-09	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.5
Autonomic ganglia	CHP212	11
Autonomic ganglia	IMR32	10.1
Autonomic ganglia	KELLY	9.7
Autonomic ganglia	KPNRTBM1	10.5
Autonomic ganglia	KPNSI9S	9.4
Autonomic ganglia	KPNYN	10.6
Autonomic ganglia	MHHNB11	11.8
Autonomic ganglia	NB1	9.8
Autonomic ganglia	NH6	10.4
Autonomic ganglia	SHSY5Y	10.5
Autonomic ganglia	SIMA	10.1
Autonomic ganglia	SKNAS	9.7
Autonomic ganglia	SKNBE2	10.4
Autonomic ganglia	SKNDZ	9.5
Autonomic ganglia	SKNFI	10.5
Autonomic ganglia	SKNSH	9.8
Biliary tract	HUCCT1	10.2
Biliary tract	HUH28	9.8
Biliary tract	SNU1079	9.7
Biliary tract	SNU1196	10.1
Biliary tract	SNU245	9.4
Biliary tract	SNU308	9.5
Biliary tract	SNU478	9.8
Bone	143B	10.7
Bone	A673	10.4
Bone	CADOES1	10.2
Bone	CAL78	8.9
Bone	G292CLONEA141B1	10.1
Bone	HOS	10.5
Bone	HS706T	10.5
Bone	HS737T	10.8
Bone	HS819T	10.7
Bone	HS821T	10.4
Bone	HS822T	10.3
Bone	HS863T	10.9
Bone	HS870T	10.9
Bone	HS888T	11.1
Bone	MG63	9.9
Bone	MHHES1	10.1
Bone	OUMS27	9.5
Bone	RDES	8.8
Bone	SJSA1	9.1
Bone	SKES1	10.5
Bone	SKNMC	10.6
Bone	SW1353	10.3
Bone	T173	11
Bone	TC71	10.1
Bone	U2OS	9.5
Breast	AU565	9.2
Breast	BT20	10
Breast	BT474	8.6
Breast	BT483	9.6
Breast	BT549	11
Breast	CAL120	9.8
Breast	CAL148	10
Breast	CAL51	10.3
Breast	CAL851	10.9
Breast	CAMA1	10.1
Breast	DU4475	10
Breast	EFM192A	9.5
Breast	EFM19	9.5
Breast	EVSAT	9.3
Breast	HCC1143	9.4
Breast	HCC1187	10.9
Breast	HCC1395	10.8
Breast	HCC1419	9.2
Breast	HCC1428	8.6
Breast	HCC1500	9.9
Breast	HCC1569	8.9
Breast	HCC1599	11.2
Breast	HCC1806	9.1
Breast	HCC1937	10.5
Breast	HCC1954	11.5
Breast	HCC202	10.5
Breast	HCC2157	11.2
Breast	HCC2218	9.9
Breast	HCC38	10.5
Breast	HCC70	11
Breast	HDQP1	10.2
Breast	HMC18	11.6
Breast	HS274T	11.2
Breast	HS281T	10.7
Breast	HS343T	10.8
Breast	HS578T	10.6
Breast	HS606T	10.2
Breast	HS739T	10
Breast	HS742T	10.3
Breast	JIMT1	9.4
Breast	KPL1	9.6
Breast	MCF7	9.5
Breast	MDAMB134VI	10.5
Breast	MDAMB157	9.8
Breast	MDAMB175VII	9.5
Breast	MDAMB231	9
Breast	MDAMB361	9.4
Breast	MDAMB415	9.6
Breast	MDAMB436	10.7
Breast	MDAMB453	8.6
Breast	MDAMB468	9.7
Breast	SKBR3	9.4
Breast	T47D	9.7
Breast	UACC812	9.9
Breast	UACC893	9.4
Breast	YMB1	9.9
Breast	ZR751	10.5
Breast	ZR7530	10
Central nervous system	1321N1	10.2
Central nervous system	42MGBA	10
Central nervous system	8MGBA	9.7
Central nervous system	A172	10.1
Central nervous system	AM38	10.4
Central nervous system	BECKER	9.8
Central nervous system	CAS1	11.1
Central nervous system	CCFSTTG1	10.4
Central nervous system	D283MED	10.1
Central nervous system	D341MED	9.9
Central nervous system	DAOY	11.1
Central nervous system	DBTRG05MG	10.1
Central nervous system	DKMG	10.3
Central nervous system	GAMG	9.7
Central nervous system	GB1	8.2
Central nervous system	GI1	10.5
Central nervous system	GMS10	10.3
Central nervous system	GOS3	9.4
Central nervous system	H4	9.5
Central nervous system	HS683	10
Central nervous system	KALS1	10.7
Central nervous system	KG1C	11.4
Central nervous system	KNS42	10
Central nervous system	KNS60	10.4
Central nervous system	KNS81	9.7
Central nervous system	KS1	10.4
Central nervous system	LN18	9.2
Central nervous system	LN229	10.4
Central nervous system	M059K	9.9
Central nervous system	MOGGCCM	10.8
Central nervous system	MOGGUVW	10.5
Central nervous system	NMCG1	10
Central nervous system	ONS76	10.9
Central nervous system	SF126	8.9
Central nervous system	SF295	10.2
Central nervous system	SNB19	10
Central nervous system	SNU1105	10.5
Central nervous system	SNU201	10.3
Central nervous system	SNU466	8.7
Central nervous system	SNU489	8.9
Central nervous system	SNU626	10.2
Central nervous system	SNU738	7.9
Central nervous system	SW1088	9.7
Central nervous system	SW1783	10.1
Central nervous system	T98G	9.5
Central nervous system	TM31	9.2
Central nervous system	U118MG	11.1
Central nervous system	U138MG	10.9
Central nervous system	U251MG	10.1
Central nervous system	U87MG	9.6
Central nervous system	YH13	11
Central nervous system	YKG1	9.6
Endometrium	AN3CA	9.8
Endometrium	COLO684	10.4
Endometrium	EFE184	9.9
Endometrium	EN	10.1
Endometrium	ESS1	9.9
Endometrium	HEC108	9.9
Endometrium	HEC151	9.1
Endometrium	HEC1A	8.7
Endometrium	HEC1B	10.2
Endometrium	HEC251	10.6
Endometrium	HEC265	9.7
Endometrium	HEC50B	9
Endometrium	HEC59	9.7
Endometrium	HEC6	10
Endometrium	ISHIKAWAHERAKLIO02ER	10
Endometrium	JHUEM1	10
Endometrium	JHUEM2	9.7
Endometrium	JHUEM3	9.8
Endometrium	KLE	8.3
Endometrium	MFE280	10.4
Endometrium	MFE296	10.1
Endometrium	MFE319	9.7
Endometrium	RL952	10.3
Endometrium	SNGM	9.7
Endometrium	SNU1077	9.7
Endometrium	SNU685	9.7
Endometrium	TEN	9.4
Haematopoietic and lymphoid	697	11.5
Haematopoietic and lymphoid	A3KAW	9.9
Haematopoietic and lymphoid	A4FUK	10.4
Haematopoietic and lymphoid	ALLSIL	11.7
Haematopoietic and lymphoid	AML193	10.6
Haematopoietic and lymphoid	AMO1	10.6
Haematopoietic and lymphoid	BCP1	10.4
Haematopoietic and lymphoid	BDCM	9.9
Haematopoietic and lymphoid	BL41	11
Haematopoietic and lymphoid	BL70	11
Haematopoietic and lymphoid	BV173	13
Haematopoietic and lymphoid	CA46	12.1
Haematopoietic and lymphoid	CI1	10.6
Haematopoietic and lymphoid	CMK115	9.4
Haematopoietic and lymphoid	CMK86	9.8
Haematopoietic and lymphoid	CMK	9.7
Haematopoietic and lymphoid	CMLT1	11
Haematopoietic and lymphoid	COLO775	10
Haematopoietic and lymphoid	DAUDI	11.7
Haematopoietic and lymphoid	DB	10.6
Haematopoietic and lymphoid	DEL	11.4
Haematopoietic and lymphoid	DND41	10.3
Haematopoietic and lymphoid	DOHH2	11.6
Haematopoietic and lymphoid	EB1	11.9
Haematopoietic and lymphoid	EB2	12.5
Haematopoietic and lymphoid	EHEB	10.7
Haematopoietic and lymphoid	EJM	10.7
Haematopoietic and lymphoid	EM2	10.6
Haematopoietic and lymphoid	EOL1	11.8
Haematopoietic and lymphoid	F36P	10.3
Haematopoietic and lymphoid	GA10	11.1
Haematopoietic and lymphoid	GDM1	10.6
Haematopoietic and lymphoid	GRANTA519	11.4
Haematopoietic and lymphoid	HDLM2	12
Haematopoietic and lymphoid	HDMYZ	11.4
Haematopoietic and lymphoid	HEL9217	11
Haematopoietic and lymphoid	HEL	10.9
Haematopoietic and lymphoid	HH	10.8
Haematopoietic and lymphoid	HL60	11.3
Haematopoietic and lymphoid	HPBALL	11.4
Haematopoietic and lymphoid	HS604T	9.7
Haematopoietic and lymphoid	HS611T	10.7
Haematopoietic and lymphoid	HS616T	10.6
Haematopoietic and lymphoid	HS751T	11
Haematopoietic and lymphoid	HT	10.2
Haematopoietic and lymphoid	HTK	11.4
Haematopoietic and lymphoid	HUNS1	10.6
Haematopoietic and lymphoid	HUT102	10.7
Haematopoietic and lymphoid	HUT78	10.9
Haematopoietic and lymphoid	JEKO1	10.6
Haematopoietic and lymphoid	JK1	10.5
Haematopoietic and lymphoid	JM1	11.4
Haematopoietic and lymphoid	JURKAT	11.6
Haematopoietic and lymphoid	JURLMK1	10
Haematopoietic and lymphoid	JVM2	10.3
Haematopoietic and lymphoid	JVM3	10.6
Haematopoietic and lymphoid	K562	9.7
Haematopoietic and lymphoid	KARPAS299	11.9
Haematopoietic and lymphoid	KARPAS422	10.6
Haematopoietic and lymphoid	KARPAS620	10
Haematopoietic and lymphoid	KASUMI1	9.9
Haematopoietic and lymphoid	KASUMI2	11.2
Haematopoietic and lymphoid	KASUMI6	10.6
Haematopoietic and lymphoid	KCL22	11.2
Haematopoietic and lymphoid	KE37	11.6
Haematopoietic and lymphoid	KE97	10.1
Haematopoietic and lymphoid	KG1	11.1
Haematopoietic and lymphoid	KHM1B	10.7
Haematopoietic and lymphoid	KIJK	11.3
Haematopoietic and lymphoid	KMH2	11.2
Haematopoietic and lymphoid	KMM1	10.4
Haematopoietic and lymphoid	KMS11	10.5
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	10.7
Haematopoietic and lymphoid	KMS20	10.8
Haematopoietic and lymphoid	KMS21BM	9.2
Haematopoietic and lymphoid	KMS26	10.2
Haematopoietic and lymphoid	KMS27	10
Haematopoietic and lymphoid	KMS28BM	11.1
Haematopoietic and lymphoid	KMS34	10.3
Haematopoietic and lymphoid	KO52	10.8
Haematopoietic and lymphoid	KOPN8	10.5
Haematopoietic and lymphoid	KU812	10.4
Haematopoietic and lymphoid	KYO1	9.3
Haematopoietic and lymphoid	L1236	10.1
Haematopoietic and lymphoid	L363	10.9
Haematopoietic and lymphoid	L428	10.8
Haematopoietic and lymphoid	L540	12.1
Haematopoietic and lymphoid	LAMA84	10.4
Haematopoietic and lymphoid	LOUCY	10.6
Haematopoietic and lymphoid	LP1	9.7
Haematopoietic and lymphoid	M07E	11.1
Haematopoietic and lymphoid	MC116	10.2
Haematopoietic and lymphoid	ME1	9.6
Haematopoietic and lymphoid	MEC1	10.1
Haematopoietic and lymphoid	MEC2	10.6
Haematopoietic and lymphoid	MEG01	10
Haematopoietic and lymphoid	MHHCALL2	11.3
Haematopoietic and lymphoid	MHHCALL3	10.5
Haematopoietic and lymphoid	MHHCALL4	11.6
Haematopoietic and lymphoid	MINO	10.5
Haematopoietic and lymphoid	MJ	10.8
Haematopoietic and lymphoid	MM1S	10.5
Haematopoietic and lymphoid	MOLM13	11.6
Haematopoietic and lymphoid	MOLM16	10.4
Haematopoietic and lymphoid	MOLM6	10.6
Haematopoietic and lymphoid	MOLP2	10.5
Haematopoietic and lymphoid	MOLP8	10.3
Haematopoietic and lymphoid	MOLT13	12
Haematopoietic and lymphoid	MOLT16	10.8
Haematopoietic and lymphoid	MOLT4	11.1
Haematopoietic and lymphoid	MONOMAC1	11.3
Haematopoietic and lymphoid	MONOMAC6	11.6
Haematopoietic and lymphoid	MOTN1	11.5
Haematopoietic and lymphoid	MUTZ5	12.1
Haematopoietic and lymphoid	MV411	11.7
Haematopoietic and lymphoid	NALM19	10
Haematopoietic and lymphoid	NALM1	11
Haematopoietic and lymphoid	NALM6	11.6
Haematopoietic and lymphoid	NAMALWA	11.6
Haematopoietic and lymphoid	NB4	12.1
Haematopoietic and lymphoid	NCIH929	10.2
Haematopoietic and lymphoid	NCO2	10.2
Haematopoietic and lymphoid	NOMO1	10
Haematopoietic and lymphoid	NUDHL1	12.1
Haematopoietic and lymphoid	NUDUL1	11.7
Haematopoietic and lymphoid	OCIAML2	11.9
Haematopoietic and lymphoid	OCIAML3	11.4
Haematopoietic and lymphoid	OCIAML5	11
Haematopoietic and lymphoid	OCILY10	10.3
Haematopoietic and lymphoid	OCILY19	12.5
Haematopoietic and lymphoid	OCILY3	10.4
Haematopoietic and lymphoid	OCIM1	13.1
Haematopoietic and lymphoid	OPM2	10.6
Haematopoietic and lymphoid	P12ICHIKAWA	10.9
Haematopoietic and lymphoid	P31FUJ	9.8
Haematopoietic and lymphoid	P3HR1	11
Haematopoietic and lymphoid	PCM6	9.4
Haematopoietic and lymphoid	PEER	11.3
Haematopoietic and lymphoid	PF382	11.8
Haematopoietic and lymphoid	PFEIFFER	10.6
Haematopoietic and lymphoid	PL21	11.2
Haematopoietic and lymphoid	RAJI	10.7
Haematopoietic and lymphoid	RCHACV	10.9
Haematopoietic and lymphoid	REC1	9.3
Haematopoietic and lymphoid	REH	11.4
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	10.2
Haematopoietic and lymphoid	RPMI8226	9.5
Haematopoietic and lymphoid	RPMI8402	11.3
Haematopoietic and lymphoid	RS411	10.8
Haematopoietic and lymphoid	SEM	10.8
Haematopoietic and lymphoid	SET2	11.7
Haematopoietic and lymphoid	SIGM5	11.2
Haematopoietic and lymphoid	SKM1	11
Haematopoietic and lymphoid	SKMM2	10.2
Haematopoietic and lymphoid	SR786	11.5
Haematopoietic and lymphoid	ST486	10.9
Haematopoietic and lymphoid	SUDHL10	10.8
Haematopoietic and lymphoid	SUDHL1	11.7
Haematopoietic and lymphoid	SUDHL4	10.6
Haematopoietic and lymphoid	SUDHL5	11.4
Haematopoietic and lymphoid	SUDHL6	11.1
Haematopoietic and lymphoid	SUDHL8	11.8
Haematopoietic and lymphoid	SUPB15	10.8
Haematopoietic and lymphoid	SUPHD1	12
Haematopoietic and lymphoid	SUPM2	10.7
Haematopoietic and lymphoid	SUPT11	11.3
Haematopoietic and lymphoid	SUPT1	10.8
Haematopoietic and lymphoid	TALL1	11.4
Haematopoietic and lymphoid	TF1	9.8
Haematopoietic and lymphoid	THP1	11.6
Haematopoietic and lymphoid	TO175T	10.8
Haematopoietic and lymphoid	TOLEDO	11
Haematopoietic and lymphoid	U266B1	10.3
Haematopoietic and lymphoid	U937	10.7
Haematopoietic and lymphoid	UT7	10.9
Haematopoietic and lymphoid	WSUDLCL2	11.6
Kidney	769P	9.8
Kidney	786O	9.5
Kidney	A498	9.9
Kidney	A704	9
Kidney	ACHN	9.6
Kidney	BFTC909	12.7
Kidney	CAKI1	9.2
Kidney	CAKI2	8.5
Kidney	CAL54	9.7
Kidney	KMRC1	9.9
Kidney	KMRC20	9.8
Kidney	KMRC2	9.4
Kidney	KMRC3	9.9
Kidney	OSRC2	9.2
Kidney	RCC10RGB	9.1
Kidney	SNU1272	10.2
Kidney	SNU349	8.9
Kidney	TUHR10TKB	9.3
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	9.2
Kidney	VMRCRCW	9.5
Kidney	VMRCRCZ	9.5
Large intestine	C2BBE1	9.2
Large intestine	CCK81	9.9
Large intestine	CL11	9.8
Large intestine	CL14	10.2
Large intestine	CL34	10.3
Large intestine	CL40	9.1
Large intestine	COLO205	9.6
Large intestine	COLO320	10
Large intestine	COLO678	10.2
Large intestine	CW2	9.4
Large intestine	DLD1	9.5
Large intestine	GP2D	10.1
Large intestine	HCC56	10.8
Large intestine	HCT116	9.4
Large intestine	HCT15	9.6
Large intestine	HS675T	10.1
Large intestine	HS698T	11.3
Large intestine	HT115	10.1
Large intestine	HT29	10
Large intestine	HT55	9.3
Large intestine	KM12	10.8
Large intestine	LOVO	10
Large intestine	LS1034	10.2
Large intestine	LS123	10
Large intestine	LS180	10
Large intestine	LS411N	10.2
Large intestine	LS513	10.3
Large intestine	MDST8	10
Large intestine	NCIH508	10.3
Large intestine	NCIH716	8.2
Large intestine	NCIH747	10.4
Large intestine	OUMS23	9.8
Large intestine	RCM1	10.3
Large intestine	RKO	10.5
Large intestine	SKCO1	10.6
Large intestine	SNU1040	10.3
Large intestine	SNU1197	10.4
Large intestine	SNU175	10.5
Large intestine	SNU283	9.8
Large intestine	SNU407	9.9
Large intestine	SNU503	10.2
Large intestine	SNU61	9.2
Large intestine	SNU81	10.9
Large intestine	SNUC1	9.7
Large intestine	SNUC2A	8.8
Large intestine	SNUC4	9.8
Large intestine	SNUC5	10.5
Large intestine	SW1116	9.7
Large intestine	SW1417	9.6
Large intestine	SW1463	9.7
Large intestine	SW403	9.5
Large intestine	SW480	9.5
Large intestine	SW48	10.1
Large intestine	SW620	10
Large intestine	SW837	10.3
Large intestine	SW948	9.3
Large intestine	T84	8.5
Liver	ALEXANDERCELLS	7.8
Liver	C3A	9.7
Liver	HEP3B217	10.6
Liver	HEPG2	9.4
Liver	HLE	9.4
Liver	HLF	9
Liver	HUH1	8.6
Liver	HUH6	10
Liver	HUH7	9.7
Liver	JHH1	9.3
Liver	JHH2	8.8
Liver	JHH4	9.6
Liver	JHH5	9.6
Liver	JHH6	10.8
Liver	JHH7	9.3
Liver	LI7	9.8
Liver	PLCPRF5	8.5
Liver	SKHEP1	9.7
Liver	SNU182	9.7
Liver	SNU387	10.1
Liver	SNU398	9.5
Liver	SNU423	10.2
Liver	SNU449	10.1
Liver	SNU475	9
Liver	SNU761	10.2
Liver	SNU878	8.3
Liver	SNU886	9.2
Lung	A549	9.9
Lung	ABC1	8.2
Lung	BEN	9
Lung	CAL12T	10.1
Lung	CALU1	10.2
Lung	CALU3	9.7
Lung	CALU6	9.9
Lung	CHAGOK1	9
Lung	COLO668	10.1
Lung	COLO699	9
Lung	CORL105	9.7
Lung	CORL23	11
Lung	CORL24	9.2
Lung	CORL279	10.3
Lung	CORL311	9.2
Lung	CORL47	10.3
Lung	CORL51	10.2
Lung	CORL88	10.6
Lung	CORL95	10.4
Lung	CPCN	10.5
Lung	DMS114	9.3
Lung	DMS153	10.4
Lung	DMS273	9.8
Lung	DMS454	9.6
Lung	DMS53	9.9
Lung	DMS79	10.4
Lung	DV90	9.4
Lung	EBC1	9.6
Lung	EPLC272H	10
Lung	HARA	9.6
Lung	HCC1171	10.8
Lung	HCC1195	9.1
Lung	HCC15	8.8
Lung	HCC2279	8.9
Lung	HCC2935	9.7
Lung	HCC33	11.3
Lung	HCC366	10.2
Lung	HCC4006	10.9
Lung	HCC44	9.9
Lung	HCC78	10.6
Lung	HCC827	10.5
Lung	HCC95	9.9
Lung	HLC1	8.8
Lung	HLFA	9.9
Lung	HS229T	10.6
Lung	HS618T	10.3
Lung	IALM	10.9
Lung	KNS62	10.8
Lung	LC1F	10.5
Lung	LC1SQSF	11
Lung	LCLC103H	11.3
Lung	LCLC97TM1	10
Lung	LK2	10.1
Lung	LOUNH91	9.7
Lung	LU65	9.8
Lung	LU99	8.5
Lung	LUDLU1	8.6
Lung	LXF289	11.6
Lung	MORCPR	9.4
Lung	NCIH1048	10.3
Lung	NCIH1092	10.9
Lung	NCIH1105	11
Lung	NCIH1155	9.7
Lung	NCIH1184	10.6
Lung	NCIH1299	10.8
Lung	NCIH1339	10.8
Lung	NCIH1341	9.3
Lung	NCIH1355	9.4
Lung	NCIH1373	11.6
Lung	NCIH1385	9.7
Lung	NCIH1395	10
Lung	NCIH1435	9.1
Lung	NCIH1436	10.4
Lung	NCIH1437	8.9
Lung	NCIH146	9.8
Lung	NCIH1563	10.4
Lung	NCIH1568	9.7
Lung	NCIH1573	9.3
Lung	NCIH1581	8.5
Lung	NCIH1618	10.3
Lung	NCIH1623	8.9
Lung	NCIH1648	9.1
Lung	NCIH1650	9.8
Lung	NCIH1651	8.7
Lung	NCIH1666	9.9
Lung	NCIH1693	10.1
Lung	NCIH1694	10.4
Lung	NCIH1703	9.2
Lung	NCIH1734	9.1
Lung	NCIH1755	9
Lung	NCIH1781	9.8
Lung	NCIH1792	8.4
Lung	NCIH1793	9.5
Lung	NCIH1836	10.9
Lung	NCIH1838	9.5
Lung	NCIH1869	10.6
Lung	NCIH1876	11.6
Lung	NCIH1915	10.8
Lung	NCIH1930	10.7
Lung	NCIH1944	9.9
Lung	NCIH1963	11
Lung	NCIH196	9.8
Lung	NCIH1975	9.7
Lung	NCIH2009	10.2
Lung	NCIH2023	9.4
Lung	NCIH2029	9.9
Lung	NCIH2030	9.2
Lung	NCIH2066	10.1
Lung	NCIH2081	10.6
Lung	NCIH2085	9.6
Lung	NCIH2087	9.7
Lung	NCIH209	10.1
Lung	NCIH2106	10.2
Lung	NCIH2110	10.3
Lung	NCIH211	9
Lung	NCIH2122	9.9
Lung	NCIH2126	9.9
Lung	NCIH2141	11.6
Lung	NCIH2170	10.1
Lung	NCIH2171	9.4
Lung	NCIH2172	10.2
Lung	NCIH2196	11.6
Lung	NCIH2227	9.7
Lung	NCIH2228	9.7
Lung	NCIH226	9
Lung	NCIH2286	10.4
Lung	NCIH2291	10.8
Lung	NCIH2342	9.1
Lung	NCIH2347	8.3
Lung	NCIH23	8.9
Lung	NCIH2405	10.1
Lung	NCIH2444	9.8
Lung	NCIH292	10.3
Lung	NCIH322	10.1
Lung	NCIH3255	8.9
Lung	NCIH358	10.2
Lung	NCIH441	9.8
Lung	NCIH446	11.2
Lung	NCIH460	9.7
Lung	NCIH510	9.8
Lung	NCIH520	10.2
Lung	NCIH522	9.4
Lung	NCIH524	10
Lung	NCIH526	10.3
Lung	NCIH596	10.2
Lung	NCIH647	9.8
Lung	NCIH650	11
Lung	NCIH661	8.9
Lung	NCIH69	10.8
Lung	NCIH727	8.6
Lung	NCIH810	9.8
Lung	NCIH82	10.1
Lung	NCIH838	10.1
Lung	NCIH841	9.8
Lung	NCIH854	8.3
Lung	NCIH889	10.7
Lung	PC14	9.5
Lung	RERFLCAD1	10.1
Lung	RERFLCAD2	9.6
Lung	RERFLCAI	8.9
Lung	RERFLCKJ	10.2
Lung	RERFLCMS	9.5
Lung	RERFLCSQ1	10
Lung	SBC5	9.4
Lung	SCLC21H	11.7
Lung	SHP77	8.9
Lung	SKLU1	10
Lung	SKMES1	10.7
Lung	SQ1	8.8
Lung	SW1271	9.3
Lung	SW1573	9.9
Lung	SW900	10.3
Lung	VMRCLCD	9.3
Lung	VMRCLCP	8.4
Oesophagus	COLO680N	10.6
Oesophagus	ECGI10	11.7
Oesophagus	KYSE140	10
Oesophagus	KYSE150	12.1
Oesophagus	KYSE180	9.8
Oesophagus	KYSE270	9.8
Oesophagus	KYSE30	9.8
Oesophagus	KYSE410	9.8
Oesophagus	KYSE450	10.3
Oesophagus	KYSE510	10.4
Oesophagus	KYSE520	9
Oesophagus	KYSE70	11.5
Oesophagus	OE19	9.6
Oesophagus	OE33	10.5
Oesophagus	TE10	9.3
Oesophagus	TE11	10
Oesophagus	TE14	9.7
Oesophagus	TE15	9.6
Oesophagus	TE1	9.6
Oesophagus	TE4	8.9
Oesophagus	TE5	9.1
Oesophagus	TE6	10
Oesophagus	TE8	10.9
Oesophagus	TE9	9.5
Oesophagus	TT	9.7
Ovary	59M	9.1
Ovary	A2780	10.3
Ovary	CAOV3	9.1
Ovary	CAOV4	9.4
Ovary	COLO704	9.9
Ovary	COV318	9
Ovary	COV362	9.6
Ovary	COV434	9.2
Ovary	COV504	10.5
Ovary	COV644	9.4
Ovary	EFO21	9.6
Ovary	EFO27	9.3
Ovary	ES2	10.1
Ovary	FUOV1	10.3
Ovary	HEYA8	10.3
Ovary	HS571T	10.5
Ovary	IGROV1	10.1
Ovary	JHOC5	9.3
Ovary	JHOM1	10
Ovary	JHOM2B	10.8
Ovary	JHOS2	9.8
Ovary	JHOS4	9
Ovary	KURAMOCHI	10.4
Ovary	MCAS	9.5
Ovary	NIHOVCAR3	10.4
Ovary	OAW28	10.6
Ovary	OAW42	8.8
Ovary	OC314	10.1
Ovary	OC316	9.9
Ovary	ONCODG1	9.9
Ovary	OV56	10.5
Ovary	OV7	10.4
Ovary	OV90	9.3
Ovary	OVCAR4	10.6
Ovary	OVCAR8	9.3
Ovary	OVISE	9.4
Ovary	OVK18	9.7
Ovary	OVKATE	9
Ovary	OVMANA	9.9
Ovary	OVSAHO	9.5
Ovary	OVTOKO	9.2
Ovary	RMGI	9.2
Ovary	RMUGS	8.8
Ovary	SKOV3	10
Ovary	SNU119	10.4
Ovary	SNU840	9.3
Ovary	SNU8	9.9
Ovary	TOV112D	10.4
Ovary	TOV21G	10.1
Ovary	TYKNU	9.2
Pancreas	ASPC1	8.4
Pancreas	BXPC3	9.5
Pancreas	CAPAN1	9.9
Pancreas	CAPAN2	9.8
Pancreas	CFPAC1	9.8
Pancreas	DANG	9.3
Pancreas	HPAC	11.1
Pancreas	HPAFII	9.4
Pancreas	HS766T	10.9
Pancreas	HUPT3	9.5
Pancreas	HUPT4	10.9
Pancreas	KCIMOH1	10.1
Pancreas	KLM1	9.9
Pancreas	KP2	9.1
Pancreas	KP3	9.5
Pancreas	KP4	10.9
Pancreas	L33	10.1
Pancreas	MIAPACA2	10.8
Pancreas	PANC0203	10.5
Pancreas	PANC0213	10.6
Pancreas	PANC0327	10.4
Pancreas	PANC0403	9.9
Pancreas	PANC0504	9.6
Pancreas	PANC0813	10.6
Pancreas	PANC1005	10.5
Pancreas	PANC1	9
Pancreas	PATU8902	10.4
Pancreas	PATU8988S	8.1
Pancreas	PATU8988T	9.6
Pancreas	PK1	9.5
Pancreas	PK45H	9.6
Pancreas	PK59	10
Pancreas	PL45	10.2
Pancreas	PSN1	10.1
Pancreas	QGP1	8.8
Pancreas	SNU213	9.1
Pancreas	SNU324	10
Pancreas	SNU410	9.1
Pancreas	SU8686	9.2
Pancreas	SUIT2	9.9
Pancreas	SW1990	10.6
Pancreas	T3M4	9.6
Pancreas	TCCPAN2	10
Pancreas	YAPC	10.2
Pleura	ACCMESO1	10.2
Pleura	DM3	10.1
Pleura	ISTMES1	9.2
Pleura	ISTMES2	10.3
Pleura	JL1	9.3
Pleura	MPP89	9.5
Pleura	MSTO211H	10.5
Pleura	NCIH2052	10.5
Pleura	NCIH2452	9.5
Pleura	NCIH28	9.4
Prostate	22RV1	9.9
Prostate	DU145	10.2
Prostate	LNCAPCLONEFGC	10.3
Prostate	MDAPCA2B	10.6
Prostate	NCIH660	10.6
Prostate	PC3	10.4
Prostate	VCAP	9.8
Salivary gland	A253	10.8
Salivary gland	YD15	9.3
Skin	A101D	9.6
Skin	A2058	11
Skin	A375	10.4
Skin	C32	9.6
Skin	CHL1	10
Skin	CJM	11.2
Skin	COLO679	8.5
Skin	COLO741	9.3
Skin	COLO783	9.3
Skin	COLO792	9.4
Skin	COLO800	9.5
Skin	COLO818	8.9
Skin	COLO829	9.8
Skin	COLO849	10.1
Skin	G361	9.5
Skin	GRM	9.2
Skin	HMCB	10.1
Skin	HS294T	9.6
Skin	HS600T	10.8
Skin	HS688AT	10.3
Skin	HS695T	9.7
Skin	HS839T	10.9
Skin	HS852T	10.4
Skin	HS895T	10.2
Skin	HS934T	11.4
Skin	HS936T	9.4
Skin	HS939T	10.4
Skin	HS940T	10.4
Skin	HS944T	10
Skin	HT144	10.2
Skin	IGR1	11
Skin	IGR37	9.5
Skin	IGR39	10.3
Skin	IPC298	10.3
Skin	K029AX	9
Skin	LOXIMVI	10.8
Skin	MALME3M	9.4
Skin	MDAMB435S	10.4
Skin	MELHO	9.5
Skin	MELJUSO	9
Skin	MEWO	9.9
Skin	RPMI7951	10.4
Skin	RVH421	11.1
Skin	SH4	10.3
Skin	SKMEL1	9.1
Skin	SKMEL24	9.3
Skin	SKMEL28	10.3
Skin	SKMEL2	10.1
Skin	SKMEL30	9.6
Skin	SKMEL31	9.5
Skin	SKMEL3	8.9
Skin	SKMEL5	9
Skin	UACC257	9.9
Skin	UACC62	9.7
Skin	WM115	8.9
Skin	WM1799	10.5
Skin	WM2664	9.6
Skin	WM793	10
Skin	WM88	9.5
Skin	WM983B	8.9
Small intestine	HUTU80	10.2
Soft tissue	A204	10.4
Soft tissue	G401	10.3
Soft tissue	G402	10.1
Soft tissue	GCT	10
Soft tissue	HS729	10
Soft tissue	HT1080	11
Soft tissue	KYM1	9.9
Soft tissue	MESSA	9.9
Soft tissue	RD	9.2
Soft tissue	RH30	8.5
Soft tissue	RH41	10.1
Soft tissue	RKN	11.7
Soft tissue	S117	11.1
Soft tissue	SJRH30	10.1
Soft tissue	SKLMS1	10.5
Soft tissue	SKUT1	10.5
Soft tissue	TE125T	11.6
Soft tissue	TE159T	11.2
Soft tissue	TE441T	9.8
Soft tissue	TE617T	9.5
Stomach	2313287	10.1
Stomach	AGS	10.4
Stomach	AZ521	10
Stomach	ECC10	11.1
Stomach	ECC12	10.2
Stomach	FU97	9.2
Stomach	GCIY	8.7
Stomach	GSS	10.6
Stomach	GSU	10
Stomach	HGC27	10.7
Stomach	HS746T	11.5
Stomach	HUG1N	8.6
Stomach	IM95	9.3
Stomach	KATOIII	9.2
Stomach	KE39	10.3
Stomach	LMSU	9
Stomach	MKN1	8.6
Stomach	MKN45	9.7
Stomach	MKN74	9.2
Stomach	MKN7	9.3
Stomach	NCCSTCK140	10.7
Stomach	NCIN87	10.4
Stomach	NUGC2	7.3
Stomach	NUGC3	10.2
Stomach	NUGC4	10.8
Stomach	OCUM1	9.9
Stomach	RERFGC1B	9.1
Stomach	SH10TC	8.9
Stomach	SNU16	9.8
Stomach	SNU1	10
Stomach	SNU216	9.3
Stomach	SNU520	9.8
Stomach	SNU5	9.4
Stomach	SNU601	9.8
Stomach	SNU620	10.9
Stomach	SNU668	9.9
Stomach	SNU719	10.4
Stomach	TGBC11TKB	10.4
Thyroid	8305C	11.1
Thyroid	8505C	11
Thyroid	BCPAP	10.7
Thyroid	BHT101	9.9
Thyroid	CAL62	11.7
Thyroid	CGTHW1	10.8
Thyroid	FTC133	9.9
Thyroid	FTC238	10.3
Thyroid	ML1	9.3
Thyroid	SW579	9.9
Thyroid	TT2609C02	10
Thyroid	TT	9.1
Upper aerodigestive tract	BHY	11.1
Upper aerodigestive tract	BICR16	9.2
Upper aerodigestive tract	BICR18	9.1
Upper aerodigestive tract	BICR22	9.3
Upper aerodigestive tract	BICR31	9
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	9.3
Upper aerodigestive tract	CAL27	9.7
Upper aerodigestive tract	CAL33	10.6
Upper aerodigestive tract	DETROIT562	9.4
Upper aerodigestive tract	FADU	11.4
Upper aerodigestive tract	HS840T	10.5
Upper aerodigestive tract	HSC2	10.7
Upper aerodigestive tract	HSC3	10.6
Upper aerodigestive tract	HSC4	10.5
Upper aerodigestive tract	PECAPJ15	9.7
Upper aerodigestive tract	PECAPJ34CLONEC12	9.9
Upper aerodigestive tract	PECAPJ41CLONED2	9
Upper aerodigestive tract	PECAPJ49	9.7
Upper aerodigestive tract	SCC15	9.7
Upper aerodigestive tract	SCC25	9.3
Upper aerodigestive tract	SCC4	10.1
Upper aerodigestive tract	SCC9	9.8
Upper aerodigestive tract	SNU1076	8.9
Upper aerodigestive tract	SNU1214	8.4
Upper aerodigestive tract	SNU46	10.5
Upper aerodigestive tract	SNU899	10
Upper aerodigestive tract	YD10B	11.4
Upper aerodigestive tract	YD38	10.7
Upper aerodigestive tract	YD8	10.3
Urinary tract	5637	10.4
Urinary tract	639V	9.9
Urinary tract	647V	9.5
Urinary tract	BC3C	10.9
Urinary tract	BFTC905	8.8
Urinary tract	CAL29	10
Urinary tract	HS172T	10.8
Urinary tract	HT1197	9.8
Urinary tract	HT1376	10
Urinary tract	J82	10.2
Urinary tract	JMSU1	10.8
Urinary tract	KMBC2	10.9
Urinary tract	KU1919	10.6
Urinary tract	RT11284	10.1
Urinary tract	RT112	10.1
Urinary tract	RT4	9.3
Urinary tract	SCABER	10.4
Urinary tract	SW1710	9.3
Urinary tract	SW780	9.8
Urinary tract	T24	10.1
Urinary tract	TCCSUP	10.3
Urinary tract	UMUC1	10
Urinary tract	UMUC3	10.8
Urinary tract	VMCUB1	10.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	8.3
Adrenal gland	10.5
Appendix	14.4
Bone marrow	32.9
Breast	13.3
Cerebral cortex	12.5
Cervix, uterine	21
Colon	9.1
Duodenum	7
Endometrium	23.5
Epididymis	13.6
Esophagus	9.9
Fallopian tube	16
Gallbladder	13.7
Heart muscle	4.4
Kidney	9.2
Liver	4.4
Lung	12.1
Lymph node	22.2
Ovary	16.7
Pancreas	2.7
Parathyroid gland	16.8
Placenta	18.7
Prostate	27.5
Rectum	11.6
Salivary gland	3.3
Seminal vesicle	19
Skeletal muscle	3.7
Skin	8.4
Small intestine	9.2
Smooth muscle	22.5
Spleen	16.3
Stomach	8.3
Testis	17.9
Thyroid gland	14.9
Tonsil	17.8
Urinary bladder	16.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28004105	overexpression	Hepatocellular Carcinoma	The level of UHRF2 was higher in the HCC tissues compared with the adjacent non-tumor tissues, but its expression did not exhibit a significant difference between the HepG2 HCC cells and the L02 normal cells.
27738314	Underexpression	Leukemia	In contrast, UHRF2 immunostaining in human cancer tissues revealed widespread reduction or abnormal cytoplasmic localization which correlated with a higher Ki-67 and reduced 5hmC. UHRF2 expression is reduced in some leukemia cell lines, this correlates with promoter hypermethylation, and similar UHRF2 methylation profiles are seen in primary human leukemia samples. Thus, UHRF2 and 5hmC are widely present in differentiated human tissues, and UHRF2 protein is poorly expressed or mislocalized in diverse human cancers.
24573556	Overexpression	Colon Carcinoma	In the present study, we investigated the expression of ubiquitin-like with PHD and ring finger domains 2 (UHRF2) in colon cancer and adjacent normal tissues and estimated the clinicopathological significance and predictive value of UHRF2 expression in colon cancer. Using quantitative real-time PCR, tissue microarray (TMA), western blot analysis and immunohistochemical staining, we evaluated UHRF2 mRNA and protein levels in tumor tissues and paired adjacent normal epithelium. We found that UHRF2 was upregulated at both the transcriptional and translational levels in tumor tissues.
23244124	Underexpression	malignant Glioma	The expression of UHRF2 mRNA was significantly lower in the grade III and grade IV groups compared with the noncancerous brain tissue group, whereas its expression was high in A172, U251, and U373 glioma cell lines.
21666724	Overexpression (Copy Number Gain)	Breast Carcinoma	Among these, four genes (GASC1 UHRF2, KIAA1432 and C9orf123) are overexpressed only in the context of gene amplification while two genes (ERMP1 and IL33) are overexpressed independent of the copy number increase.

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.685	2.76e-57	43.1	35.1	21.8	Loss
BRCA	Breast invasive carcinoma	1075	0.609	6.95e-110	29.5	53.6	16.9	Neutral
CESC	Cervical and endocervical cancers	292	0.723	1.86e-48	19.5	59.2	21.2	Neutral
COAD	Colon adenocarcinoma	449	0.427	2.35e-21	12.9	68.6	18.5	Neutral
ESCA	Esophageal carcinoma	183	0.718	2.68e-30	58.5	27.9	13.7	Loss
GBM	Glioblastoma multiforme	147	0.714	3.01e-24	41.5	48.3	10.2	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.72	2.01e-83	41.4	35.6	23	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.385	5.68e-20	28	68.8	3.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.347	1.4e-09	12.2	86.8	1	Neutral
LAML	Acute Myeloid Leukemia	166	0.151	0.0514	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.469	1.96e-29	29.2	67.4	3.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.51	1.62e-25	31.6	60.4	8	Neutral
LUAD	Lung adenocarcinoma	512	0.656	1.94e-64	53.3	35.2	11.5	Loss
LUSC	Lung squamous cell carcinoma	498	0.711	5.23e-78	65.1	18.5	16.5	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.8	3.5e-68	44.3	28.7	27	Loss
PAAD	Pancreatic adenocarcinoma	177	0.401	3.09e-08	46.9	49.2	4	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.399	1.47e-07	9.3	87.7	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.363	9.12e-17	8.6	85.1	6.3	Neutral
READ	Rectum adenocarcinoma	164	0.512	2.51e-12	16.5	56.1	27.4	Neutral
SARC	Sarcoma	255	0.596	5.99e-26	36.1	42.7	21.2	Loss
SKCM	Skin Cutaneous Melanoma	367	0.494	5.08e-24	65.9	27.8	6.3	Loss
STAD	Stomach adenocarcinoma	413	0.631	3.58e-47	39.7	45.8	14.5	Loss
TGCT	Testicular Germ Cell Tumors	150	0.142	0.0829	44	45.3	10.7	Loss
THCA	Thyroid carcinoma	497	0.21	2.42e-06	4	95.2	0.8	Neutral
THYM	Thymoma	119	0.375	2.71e-05	5	85.7	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.464	4.73e-30	15.1	75.4	9.5	Neutral

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.032	0.506	17	408	-0.003	0.993	NS/NA
BRCA	Breast invasive carcinoma	-0.159	2.64e-06	83	785	0.052	1.64e-79	NS/NA
CESC	Cervical and endocervical cancers	-0.176	0.00188	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.077	0.173	19	297	0	0.271	NS/NA
ESCA	Esophageal carcinoma	-0.083	0.247	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.07	0.576	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	0.007	0.88	20	522	0.001	0.000535	NS/NA
KIRC	Kidney renal clear cell carcinoma	0	0.994	24	319	0.003	1.93e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.057	0.325	23	275	-0.003	0.947	NS/NA
LAML	Acute Myeloid Leukemia	-0.121	0.117	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.001	0.986	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	0.059	0.23	41	373	-0.001	0.265	NS/NA
LUAD	Lung adenocarcinoma	-0.07	0.129	21	456	-0.005	0.471	NS/NA
LUSC	Lung squamous cell carcinoma	-0.02	0.694	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.683	0.0503	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.106	0.154	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0.037	0.614	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.006	0.882	35	498	0.155	6.49e-20	NS/NA
READ	Rectum adenocarcinoma	-0.02	0.841	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.121	0.0504	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.151	0.00102	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.178	0.000569	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.399	3.22e-07	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.061	0.149	50	509	-0.002	0.649	NS/NA
THYM	Thymoma	-0.125	0.169	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.162	0.000455	34	431	0.251	1.31e-71	Increased

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.6	NS	24476821
BRCA	Breast invasive carcinoma	521	5.73e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.762	NS	22810696
GBM	Glioblastoma multiforme	157	0.0154	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0365	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.41	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.53e-06	Significant	26824661
LUAD	Lung adenocarcinoma	230	9.74e-08	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.117	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0118	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000293	Significant	26544944
READ	Rectum adenocarcinoma	67	0.761	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.751	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00278	Significant	25079317
THCA	Thyroid carcinoma	391	6.48e-08	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.584	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.125	0.573	NS
BRCA	Breast invasive carcinoma	1079	1.023	0.92	NS
CESC	Cervical and endocervical cancers	291	1.327	0.433	NS
COAD	Colon adenocarcinoma	439	1.159	0.606	NS
ESCA	Esophageal carcinoma	184	1.159	0.632	NS
GBM	Glioblastoma multiforme	158	1.092	0.756	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.096	0.628	NS
KIRC	Kidney renal clear cell carcinoma	531	0.983	0.936	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.388	0.0325	Longer
LAML	Acute Myeloid Leukemia	149	0.396	0.00162	Longer
LGG	Brain Lower Grade Glioma	511	0.968	0.887	NS
LIHC	Liver hepatocellular carcinoma	365	1.31	0.286	NS
LUAD	Lung adenocarcinoma	502	0.907	0.627	NS
LUSC	Lung squamous cell carcinoma	494	0.979	0.912	NS
OV	Ovarian serous cystadenocarcinoma	303	0.84	0.415	NS
PAAD	Pancreatic adenocarcinoma	177	1.352	0.295	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.381	0.385	NS
PRAD	Prostate adenocarcinoma	497	1.635	0.553	NS
READ	Rectum adenocarcinoma	159	0.526	0.289	NS
SARC	Sarcoma	259	1.504	0.136	NS
SKCM	Skin Cutaneous Melanoma	459	0.63	0.0155	Longer
STAD	Stomach adenocarcinoma	388	0.928	0.738	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	1.072	0.932	NS
THYM	Thymoma	119	0.098	0.0105	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.804	0.444	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.014	0.771	NS
BRCA	Breast invasive carcinoma	1071	-0.041	0.18	NS
CESC	Cervical and endocervical cancers	167	-0.008	0.919	NS
COAD	Colon adenocarcinoma	445	0.011	0.812	NS
ESCA	Esophageal carcinoma	162	0.058	0.464	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.019	0.683	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.074	0.0899	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.16	0.00978	Lower
LIHC	Liver hepatocellular carcinoma	347	0.145	0.00699	Higher
LUAD	Lung adenocarcinoma	507	-0.04	0.366	NS
LUSC	Lung squamous cell carcinoma	497	0.067	0.133	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.072	0.212	NS
PAAD	Pancreatic adenocarcinoma	176	0.017	0.822	NS
READ	Rectum adenocarcinoma	156	0.077	0.337	NS
SKCM	Skin Cutaneous Melanoma	410	-0.035	0.483	NS
STAD	Stomach adenocarcinoma	392	0.03	0.554	NS
TGCT	Testicular Germ Cell Tumors	81	-0.491	3.24e-06	Lower
THCA	Thyroid carcinoma	499	-0.129	0.00387	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.084	0.0613	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.053	0.388	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.088	0.0507	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.143	0.00104	Lower
LGG	Brain Lower Grade Glioma	514	0.031	0.481	NS
LIHC	Liver hepatocellular carcinoma	366	0.062	0.24	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.066	0.256	NS
PAAD	Pancreatic adenocarcinoma	176	0.068	0.37	NS
STAD	Stomach adenocarcinoma	406	0.096	0.053	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.061	0.159	NS

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for UHRF2.

Summary
Symbol	UHRF2
Name	ubiquitin like with PHD and ring finger domains 2
Aliases	RNF107; URF2; MGC33463; TDRD23; Np95-like ring finger protein; ubiquitin-like with PHD and ring finger domai ......
Location	9p24.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27738314	Leukemia	partner	UHRF2	Negative correlation	In contrast, UHRF2 immunostaining in human cancer tissues revealed widespread reduction or abnormal cytoplasmic localization which correlated with a higher Ki-67 and reduced 5hmC.
21666724	Breast Carcinoma	downstream	p16; p21; p27	negative regulation	Furthermore, we demonstrated that UHRF2 has the ability to suppress the expression of key cell-cycle inhibitors, such as p16(INK4a), p21(Waf1/Cip1) and p27(Kip1).