Browse UTY in pancancer

Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF02373 JmjC domain
PF13181 Tetratricopeptide repeat
Function

Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Classification
Class Modification Substrate Product PubMed
Histone modification erase Histone ubiquitination H3K27me # 24798337
> Gene Ontology
 
Biological Process GO:0006482 protein demethylation
GO:0008214 protein dealkylation
GO:0016570 histone modification
GO:0016577 histone demethylation
GO:0070076 histone lysine demethylation
GO:0070988 demethylation
GO:0071557 histone H3-K27 demethylation
Molecular Function GO:0032451 demethylase activity
GO:0032452 histone demethylase activity
GO:0051213 dioxygenase activity
GO:0071558 histone demethylase activity (H3-K27 specific)
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214842: HDMs demethylate histones
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM5418763c.112delCp.L38fs*1Deletion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM4902349c.3059G>Tp.R1020MSubstitution - MissenseSkin
COSM4111710c.536A>Gp.D179GSubstitution - MissenseStomach
COSM1756705c.2029C>Tp.P677SSubstitution - MissenseUrinary_tract
COSM5431620c.4003G>Tp.D1335YSubstitution - MissenseOesophagus
COSM4645721c.3300C>Tp.C1100CSubstitution - coding silentLarge_intestine
COSM3974026c.527T>Cp.V176ASubstitution - MissenseCentral_nervous_system
COSM3391911c.2822A>Gp.N941SSubstitution - MissensePancreas
COSM6005447c.3924T>Cp.C1308CSubstitution - coding silentProstate
COSM5757583c.1504G>Ap.V502ISubstitution - MissenseLarge_intestine
COSM3660039c.3659T>Gp.L1220RSubstitution - MissenseLiver
COSM4740048c.3029A>Gp.N1010SSubstitution - MissenseLarge_intestine
COSM1756702c.2479C>Tp.Q827*Substitution - NonsenseUrinary_tract
COSM3974023c.3455T>Cp.V1152ASubstitution - MissenseCentral_nervous_system
COSM488715c.3170C>Ap.A1057ESubstitution - MissenseKidney
COSM1469995c.3909A>Tp.V1303VSubstitution - coding silentLarge_intestine
COSM3584396c.1274T>Ap.L425*Substitution - NonsenseSkin
COSM4789876c.922A>Gp.I308VSubstitution - MissenseLiver
COSM316443c.1979G>Tp.G660VSubstitution - MissenseSoft_tissue
COSM1293085c.1264C>Tp.P422SSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4610649c.1178T>Gp.F393CSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1159056c.1777delCp.H593fs*111Deletion - FrameshiftPancreas
COSM1626211c.430C>Ap.H144NSubstitution - MissenseLiver
COSM4449551c.2674-1G>Ap.?UnknownSkin
COSM1644109c.3786A>Gp.K1262KSubstitution - coding silentStomach
COSM1741515c.3238C>Tp.Q1080*Substitution - NonsenseUrinary_tract
COSM316443c.1979G>Tp.G660VSubstitution - MissenseLung
COSM1159056c.1777delCp.H593fs*111Deletion - FrameshiftPancreas
COSM1315739c.2793C>Gp.F931LSubstitution - MissenseUrinary_tract
COSM3380265c.2422A>Gp.K808ESubstitution - MissensePancreas
COSM5120308c.3053C>Ap.S1018YSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3660036c.3671T>Ap.M1224KSubstitution - MissenseLiver
COSM3720483c.2888G>Tp.G963VSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1190663c.2252A>Tp.H751LSubstitution - MissenseLung
COSM1469997c.1169G>Tp.R390ISubstitution - MissenseLarge_intestine
COSM1715916c.3272C>Tp.P1091LSubstitution - MissenseSkin
COSM1745546c.92_93insAGp.S31fs*9Insertion - FrameshiftUrinary_tract
COSM3660039c.3659T>Gp.L1220RSubstitution - MissenseLiver
COSM3584393c.3508G>Ap.G1170SSubstitution - MissenseSkin
COSM5643478c.3692C>Gp.S1231*Substitution - NonsenseOesophagus
COSM360674c.129G>Ap.R43RSubstitution - coding silentLung
COSM3660042c.1525C>Ap.P509TSubstitution - MissenseLiver
COSM1469993c.3955T>Gp.F1319VSubstitution - MissenseLarge_intestine
COSM316441c.3430C>Gp.L1144VSubstitution - MissenseLung
COSM5724547c.1503C>Ap.S501RSubstitution - MissenseSkin
COSM3144212c.3922T>Cp.C1308RSubstitution - MissenseLarge_intestine
COSM1756702c.2479C>Tp.Q827*Substitution - NonsenseUrinary_tract
COSM3800799c.808C>Tp.L270FSubstitution - MissenseUrinary_tract
COSM316441c.3430C>Gp.L1144VSubstitution - MissenseSoft_tissue
COSM1315743c.124G>Tp.E42*Substitution - NonsenseUrinary_tract
COSM758045c.1911T>Cp.N637NSubstitution - coding silentLung
COSM4740045c.3655C>Tp.H1219YSubstitution - MissenseLarge_intestine
COSM3426800c.915G>Ap.R305RSubstitution - coding silentLarge_intestine
COSM4448963c.152+2T>Cp.?UnknownSkin
COSM1756702c.2479C>Tp.Q827*Substitution - NonsenseUrinary_tract
COSM3660036c.3671T>Ap.M1224KSubstitution - MissenseLiver
COSM5476925c.1113C>Tp.C371CSubstitution - coding silentLarge_intestine
COSM1315741c.1719G>Ap.L573LSubstitution - coding silentUrinary_tract
COSM3660042c.1525C>Ap.P509TSubstitution - MissenseLiver
COSM758047c.3846G>Tp.E1282DSubstitution - MissenseLung
COSM5809717c.588A>Tp.P196PSubstitution - coding silentLiver
COSM1756702c.2479C>Tp.Q827*Substitution - NonsenseUrinary_tract
COSM4429344c.2689G>Ap.D897NSubstitution - MissenseOesophagus
COSM4789876c.922A>Gp.I308VSubstitution - MissenseLiver
COSM4654578c.2848C>Tp.Q950*Substitution - NonsenseLarge_intestine
COSM5047409c.906_907insTp.S303fs*7Insertion - FrameshiftOesophagus
COSM1626213c.395G>Tp.G132VSubstitution - MissenseLiver
> Text Mining based Variations
 
There is no record for UTY.
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
O14607498ROmega-N-methylarginine-NoNone detected
O14607716SPhosphoserine-NoNone detected
O14607774TPhosphothreonine-NoNone detected
O14607776SPhosphoserine-NoNone detected
O14607887TPhosphothreonine-NoNone detected
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194083.7742.8811.1660.354NS
COADColon adenocarcinoma41459-2.678-0.544-0.0390.962NS
ESCAEsophageal carcinoma111854.9412.171.1520.453NS
GBMGlioblastoma multiforme51663.5783.565NANANA
HNSCHead and Neck squamous cell carcinoma445224.071.508-0.7010.347NS
KIRCKidney renal clear cell carcinoma725344.4322.657-1.2430.0462Under
KIRPKidney renal papillary cell carcinoma322914.173-0.203-1.8390.0135Under
LAMLAcute Myeloid Leukemia0173NA5.283NANANA
LGGBrain Lower Grade Glioma0530NA3.236NANANA
LIHCLiver hepatocellular carcinoma503732.662.1780.4720.524NS
LUADLung adenocarcinoma59517-4.431-4.314-0.2820.708NS
LUSCLung squamous cell carcinoma515014.3321.858-0.9530.157NS
PAADPancreatic adenocarcinoma4179-1.1281.675NANANA
PCPGPheochromocytoma and Paraganglioma31844.051-4.143NANANA
PRADProstate adenocarcinoma524984.9454.505-0.3210.000349NS
READRectum adenocarcinoma10167-6.035-0.0282.0450.22NS
SARCSarcoma2263-0.722-4.636NANANA
SKCMSkin Cutaneous Melanoma14724.7280.875NANANA
STADStomach adenocarcinoma354154.0661.611-1.1760.202NS
TGCTTesticular Germ Cell Tumors0156NA3.703NANANA
THCAThyroid carcinoma59509-6.542-6.366-0.090.908NS
THYMThymoma2120-6.9283.969NANANA
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 0
Adrenal gland 0
Appendix 3.3
Bone marrow 3.9
Breast 0
Cerebral cortex 2.9
Cervix, uterine 0
Colon 2.6
Duodenum 2.6
Endometrium 0
Epididymis 11.7
Esophagus 4.6
Fallopian tube 0
Gallbladder 5.5
Heart muscle 1.2
Kidney 1.6
Liver 2.2
Lung 3.2
Lymph node 2.8
Ovary 0
Pancreas 0.7
Parathyroid gland 0
Placenta 5
Prostate 12.9
Rectum 7
Salivary gland 0.7
Seminal vesicle 8.7
Skeletal muscle 0.6
Skin 2.2
Small intestine 7.1
Smooth muscle 0
Spleen 4.2
Stomach 3.2
Testis 7.2
Thyroid gland 4
Tonsil 5.5
Urinary bladder 5.2
> Text Mining based Expression
 
PMID Expression Cancer Evidence
18447972OverexpressionIntestinal Type Sinonasal AdenocarcinomaAlso gains of PIK3CA, UTY, and RELA correlated with poor clinical outcome.
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 
There is no record.
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.68017408NA9.63e-08NS/NA
ESCAEsophageal carcinoma-0.72309185NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.576020522NA0.689NS/NA
KIRCKidney renal clear cell carcinoma-0.709024319NA0.0605NS/NA
KIRPKidney renal papillary cell carcinoma-0.592023275NA6.88e-09NS/NA
LIHCLiver hepatocellular carcinoma-0.611041373NA3.62e-09NS/NA
LUSCLung squamous cell carcinoma-0.68508370NANANS/NA
PRADProstate adenocarcinoma-0.3187.21e-14354980.0160.153NS/NA
STADStomach adenocarcinoma-0.67200372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.59500156NANANS/NA
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 0 Not detected
Appendix 1 Low
Bone marrow 1 Low
Breast 0 Not detected
Bronchus 1 Low
Caudate 1 Low
Cerebellum 1 Low
Cerebral cortex 2 Medium
Cervix, uterine 1 Low
Colon 0 Not detected
Duodenum 1 Low
Endometrium 1 Low
Epididymis 0 Not detected
Esophagus 1 Low
Fallopian tube 0 Not detected
Gallbladder 0 Not detected
Heart muscle 0 Not detected
Hippocampus 0 Not detected
Kidney 0 Not detected
Liver 1 Low
Lung 1 Low
Lymph node 2 Medium
Nasopharynx 1 Low
Oral mucosa 0 Not detected
Ovary 0 Not detected
Pancreas 1 Low
Parathyroid gland 0 Not detected
Placenta 0 Not detected
Prostate 0 Not detected
Rectum 1 Low
Salivary gland 0 Not detected
Seminal vesicle 1 Low
Skeletal muscle 0 Not detected
Skin 0 Not detected
Small intestine 0 Not detected
Soft tissue 0 Not detected
Spleen 2 Medium
Stomach 0 Not detected
Testis 1 Low
Thyroid gland 0 Not detected
Tonsil 2 Medium
Urinary bladder 1 Low
Vagina 1 Low
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.0219Significant24476821
COADColon adenocarcinoma1490.0277Significant22810696
GBMGlioblastoma multiforme1570.71NS26824661
HNSCHead and Neck squamous cell carcinoma2790.000775Significant25631445
KIRPKidney renal papillary cell carcinoma1610.906NS26536169
LGGBrain Lower Grade Glioma5130.245NS26824661
LUADLung adenocarcinoma2304.99e-05Significant25079552
LUSCLung squamous cell carcinoma1780.749NS22960745
PRADProstate adenocarcinoma3331.62e-07Significant26544944
READRectum adenocarcinoma670.325NS22810696
SKCMSkin Cutaneous Melanoma3150.47NS26091043
STADStomach adenocarcinoma2774.33e-05Significant25079317
THCAThyroid carcinoma3910.988NS25417114
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 0.7860.264NS
COADColon adenocarcinoma439 1.5580.129NS
ESCAEsophageal carcinoma184 1.6670.148NS
GBMGlioblastoma multiforme158 0.5970.0422Longer
HNSCHead and Neck squamous cell carcinoma518 0.4440.000114Longer
KIRCKidney renal clear cell carcinoma531 0.8740.536NS
KIRPKidney renal papillary cell carcinoma287 0.7960.577NS
LAMLAcute Myeloid Leukemia149 0.6640.169NS
LGGBrain Lower Grade Glioma511 0.930.764NS
LIHCLiver hepatocellular carcinoma365 0.6310.0614NS
LUADLung adenocarcinoma502 1.0120.958NS
LUSCLung squamous cell carcinoma494 1.1650.456NS
PAADPancreatic adenocarcinoma177 0.7820.44NS
PCPGPheochromocytoma and Paraganglioma179 619625196.4870.149NS
PRADProstate adenocarcinoma497 1.8740.605NS
READRectum adenocarcinoma159 0.4250.138NS
SARCSarcoma259 0.7710.339NS
SKCMSkin Cutaneous Melanoma459 1.3040.18NS
STADStomach adenocarcinoma388 1.3390.199NS
TGCTTesticular Germ Cell Tumors134 560155184.7030.332NS
THCAThyroid carcinoma500 1.8470.397NS
THYMThymoma119 0.5120.431NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 -0.0490.32NS
COADColon adenocarcinoma445 -0.0290.536NS
ESCAEsophageal carcinoma162 0.1090.165NS
HNSCHead and Neck squamous cell carcinoma448 0.0030.947NS
KIRCKidney renal clear cell carcinoma531 0.0690.112NS
KIRPKidney renal papillary cell carcinoma260 -0.0090.879NS
LIHCLiver hepatocellular carcinoma347 -0.1260.0187Lower
LUADLung adenocarcinoma507 0.0630.158NS
LUSCLung squamous cell carcinoma497 -0.0280.533NS
PAADPancreatic adenocarcinoma176 -0.0220.775NS
READRectum adenocarcinoma156 0.0150.849NS
SKCMSkin Cutaneous Melanoma410 -0.0150.764NS
STADStomach adenocarcinoma392 00.993NS
TGCTTesticular Germ Cell Tumors81 -0.150.181NS
THCAThyroid carcinoma499 0.0980.0284Higher
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
HNSCHead and Neck squamous cell carcinoma498 0.1680.000171Higher
KIRCKidney renal clear cell carcinoma525 0.0930.0336Higher
LGGBrain Lower Grade Glioma514 -0.0380.395NS
LIHCLiver hepatocellular carcinoma366 -0.1150.0272Lower
PAADPancreatic adenocarcinoma176 0.0620.416NS
STADStomach adenocarcinoma406 -0.0070.896NS
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for UTY.
Summary
SymbolUTY
Nameubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Aliases KDM6AL; ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome; ubiquitously transcribed tetra ......
LocationYq11.221
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for UTY.
> Interactions from Text Mining
 
There is no record for UTY.