Browse VCPKMT in pancancer

Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF10294 Lysine methyltransferase
Function

Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.

Classification
Class Modification Substrate Product PubMed
# # # # #
> Gene Ontology
 
Biological Process GO:0006479 protein methylation
GO:0008213 protein alkylation
GO:0018022 peptidyl-lysine methylation
GO:0018023 peptidyl-lysine trimethylation
GO:0018205 peptidyl-lysine modification
GO:0032259 methylation
GO:0043414 macromolecule methylation
Molecular Function GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016278 lysine N-methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8876725: Protein methylation
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM3496145c.682C>Tp.P228SSubstitution - MissenseSkin
COSM1677967c.320A>Gp.N107SSubstitution - MissenseLarge_intestine
COSM3496144c.686C>Tp.S229LSubstitution - MissenseSkin
COSM3753974c.188C>Ap.A63DSubstitution - MissenseLarge_intestine
COSM1629309c.450+4A>Cp.?UnknownLiver
COSM4571831c.552T>Cp.I184ISubstitution - coding silentSkin
COSM3496145c.682C>Tp.P228SSubstitution - MissenseSkin
COSM1369939c.374A>Cp.K125TSubstitution - MissenseLarge_intestine
COSM5086782c.538A>Gp.K180ESubstitution - MissenseBreast
COSM3753974c.188C>Ap.A63DSubstitution - MissenseThyroid
COSM4551712c.537G>Ap.G179GSubstitution - coding silentSkin
COSM1369938c.587T>Gp.F196CSubstitution - MissenseLarge_intestine
COSM3419832c.674C>Tp.S225LSubstitution - MissenseLarge_intestine
COSM416679c.105C>Tp.S35SSubstitution - coding silentUrinary_tract
COSM4148107c.117T>Gp.G39GSubstitution - coding silentThyroid
COSM4188820c.202C>Tp.R68WSubstitution - MissenseKidney
COSM4187843c.478A>Gp.K160ESubstitution - MissenseKidney
COSM5967044c.77C>Tp.T26ISubstitution - MissensePituitary
COSM1196620c.562T>Gp.Y188DSubstitution - MissenseLung
COSM4569436c.175T>Ap.S59TSubstitution - MissenseSkin
COSM955988c.408A>Gp.P136PSubstitution - coding silentEndometrium
COSM5086782c.538A>Gp.K180ESubstitution - MissenseBreast
COSM1677967c.320A>Gp.N107SSubstitution - MissenseLarge_intestine
COSM469995c.615A>Gp.K205KSubstitution - coding silentKidney
COSM2198254c.138C>Tp.A46ASubstitution - coding silentSkin
COSM1726436c.568G>Tp.E190*Substitution - NonsenseLiver
COSM3753974c.188C>Ap.A63DSubstitution - MissenseLarge_intestine
COSM3744347c.14T>Cp.L5PSubstitution - MissenseLiver
COSM5971162c.98A>Gp.Y33CSubstitution - MissenseUpper_aerodigestive_tract
COSM5675158c.187G>Tp.A63SSubstitution - MissenseSoft_tissue
> Text Mining based Variations
 
There is no record for VCPKMT.
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
Q9H8678SPhosphoserine-Yesp.S8L (cancer: LUAD)
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194082.7992.8960.0810.578NS
BRCABreast invasive carcinoma11211002.6372.7270.10.0565NS
CESCCervical and endocervical cancers33063.1363.493NANANA
COADColon adenocarcinoma414592.1842.3940.0930.384NS
ESCAEsophageal carcinoma111853.1493.1840.1110.618NS
GBMGlioblastoma multiforme51663.542.34NANANA
HNSCHead and Neck squamous cell carcinoma445222.4272.8020.4024.68e-05NS
KIRCKidney renal clear cell carcinoma725342.1382.210.1390.099NS
KIRPKidney renal papillary cell carcinoma322912.0772.4780.2920.0444NS
LAMLAcute Myeloid Leukemia0173NA3.882NANANA
LGGBrain Lower Grade Glioma0530NA2.221NANANA
LIHCLiver hepatocellular carcinoma503731.7841.774-0.0420.655NS
LUADLung adenocarcinoma595172.4892.7760.3681.19e-06NS
LUSCLung squamous cell carcinoma515012.2553.0420.7645.15e-18Over
OVOvarian serous cystadenocarcinoma0307NA2.996NANANA
PAADPancreatic adenocarcinoma41792.6682.828NANANA
PCPGPheochromocytoma and Paraganglioma31842.7872.481NANANA
PRADProstate adenocarcinoma524982.3472.4690.0410.552NS
READRectum adenocarcinoma101672.4792.213-0.3260.192NS
SARCSarcoma22632.542.869NANANA
SKCMSkin Cutaneous Melanoma14723.042.329NANANA
STADStomach adenocarcinoma354152.4862.7230.2030.0624NS
TGCTTesticular Germ Cell Tumors0156NA3.111NANANA
THCAThyroid carcinoma595092.6832.7750.0480.395NS
THYMThymoma21203.6733.569NANANA
UCECUterine Corpus Endometrial Carcinoma355462.8782.932-0.030.841NS
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 2.1
Adrenal gland 3.4
Appendix 5
Bone marrow 3.3
Breast 2.5
Cerebral cortex 4.7
Cervix, uterine 2.9
Colon 2
Duodenum 1.9
Endometrium 5.3
Epididymis 3.4
Esophagus 4.1
Fallopian tube 3.1
Gallbladder 3.9
Heart muscle 0.9
Kidney 2.2
Liver 1.2
Lung 2.2
Lymph node 5.1
Ovary 1.2
Pancreas 0.2
Parathyroid gland 3.2
Placenta 2.4
Prostate 2.6
Rectum 2
Salivary gland 0.6
Seminal vesicle 2.4
Skeletal muscle 0.6
Skin 3.5
Small intestine 2.4
Smooth muscle 2.3
Spleen 3
Stomach 2.3
Testis 3.6
Thyroid gland 4.3
Tonsil 4.5
Urinary bladder 3.4
> Text Mining based Expression
 
There is no record.
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 
There is no record.
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.2521.5e-0717408-0.0010.834NS/NA
BRCABreast invasive carcinoma-0.1845.41e-0883785-0.252.08e-65Decreased
CESCCervical and endocervical cancers-0.2110.0001933306NANANS/NA
COADColon adenocarcinoma-0.2140.000135192970.0010.000347NS/NA
ESCAEsophageal carcinoma-0.3391.59e-069185NANANS/NA
GBMGlioblastoma multiforme-0.360.00341164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.1370.00143205220.010.653NS/NA
KIRCKidney renal clear cell carcinoma-0.2040.00014924319-0.1666.38e-09NS/NA
KIRPKidney renal papillary cell carcinoma-0.0430.45723275-0.0171.75e-05NS/NA
LAMLAcute Myeloid Leukemia-0.1570.04060170NANANS/NA
LGGBrain Lower Grade Glioma-0.2665.74e-100530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.2712.29e-08413730.0160.00885NS/NA
LUADLung adenocarcinoma-0.1630.00034821456-0.0140.00168NS/NA
LUSCLung squamous cell carcinoma-0.1020.04658370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.7830.017209NANANS/NA
PAADPancreatic adenocarcinoma-0.0990.1834179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.1820.01283184NANANS/NA
PRADProstate adenocarcinoma-0.2954.72e-1235498-0.0355.72e-11NS/NA
READRectum adenocarcinoma-0.1560.119299NANANS/NA
SARCSarcoma-0.3478.95e-090263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.1942.29e-051471NANANS/NA
STADStomach adenocarcinoma-0.2471.53e-060372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.2360.003140156NANANS/NA
THCAThyroid carcinoma-0.2866.45e-1250509-0.0080.551NS/NA
THYMThymoma-0.1570.08412120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.3284.99e-13344310.0060.852NS/NA
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 2 Medium
Appendix 2 Medium
Bone marrow 1 Low
Breast 2 Medium
Bronchus 2 Medium
Caudate 1 Low
Cerebellum 2 Medium
Cerebral cortex 2 Medium
Cervix, uterine 2 Medium
Colon 2 Medium
Duodenum 2 Medium
Endometrium 2 Medium
Epididymis 2 Medium
Esophagus 2 Medium
Fallopian tube 2 Medium
Gallbladder 2 Medium
Heart muscle 2 Medium
Hippocampus 1 Low
Kidney 2 Medium
Liver 2 Medium
Lung 2 Medium
Lymph node 1 Low
Nasopharynx 1 Low
Oral mucosa 2 Medium
Ovary 2 Medium
Pancreas 2 Medium
Parathyroid gland 2 Medium
Placenta 2 Medium
Prostate 2 Medium
Rectum 2 Medium
Salivary gland 2 Medium
Seminal vesicle 2 Medium
Skeletal muscle 1 Low
Skin 3 High
Small intestine 2 Medium
Smooth muscle 2 Medium
Soft tissue 3 High
Spleen 1 Low
Stomach 2 Medium
Testis 2 Medium
Thyroid gland 2 Medium
Tonsil 2 Medium
Urinary bladder 2 Medium
Vagina 2 Medium
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.696NS24476821
BRCABreast invasive carcinoma5210.823NS23000897
COADColon adenocarcinoma1490.00663Significant22810696
GBMGlioblastoma multiforme1570.597NS26824661
HNSCHead and Neck squamous cell carcinoma2792.34e-05Significant25631445
KIRPKidney renal papillary cell carcinoma1615.25e-07Significant26536169
LGGBrain Lower Grade Glioma5131.49e-07Significant26824661
LUADLung adenocarcinoma2300.0309Significant25079552
LUSCLung squamous cell carcinoma1780.00058Significant22960745
OVOvarian serous cystadenocarcinoma2870.000528Significant21720365
PRADProstate adenocarcinoma3330.61NS26544944
READRectum adenocarcinoma670.0176Significant22810696
SKCMSkin Cutaneous Melanoma3150.322NS26091043
STADStomach adenocarcinoma2770.000138Significant25079317
THCAThyroid carcinoma3910.0901NS25417114
UCECUterine Corpus Endometrial Carcinoma2320.434NS23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 0.9060.635NS
BRCABreast invasive carcinoma1079 1.1660.504NS
CESCCervical and endocervical cancers291 0.7820.51NS
COADColon adenocarcinoma439 1.1090.711NS
ESCAEsophageal carcinoma184 1.5120.205NS
GBMGlioblastoma multiforme158 0.9440.812NS
HNSCHead and Neck squamous cell carcinoma518 0.7830.195NS
KIRCKidney renal clear cell carcinoma531 1.7330.00783Shorter
KIRPKidney renal papillary cell carcinoma287 0.8820.796NS
LAMLAcute Myeloid Leukemia149 0.7410.303NS
LGGBrain Lower Grade Glioma511 1.0750.759NS
LIHCLiver hepatocellular carcinoma365 0.7370.207NS
LUADLung adenocarcinoma502 0.7850.253NS
LUSCLung squamous cell carcinoma494 0.4920.000354Longer
OVOvarian serous cystadenocarcinoma303 1.0580.801NS
PAADPancreatic adenocarcinoma177 0.5480.0685NS
PCPGPheochromocytoma and Paraganglioma179 579591168.80.323NS
PRADProstate adenocarcinoma497 684830496.8360.0351Shorter
READRectum adenocarcinoma159 1.0260.962NS
SARCSarcoma259 1.8170.0355Shorter
SKCMSkin Cutaneous Melanoma459 0.590.00849Longer
STADStomach adenocarcinoma388 0.8290.41NS
TGCTTesticular Germ Cell Tumors134 00.157NS
THCAThyroid carcinoma500 1.7370.409NS
THYMThymoma119 0.2110.148NS
UCECUterine Corpus Endometrial Carcinoma543 1.0630.837NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 -0.0940.0589NS
BRCABreast invasive carcinoma1071 00.998NS
CESCCervical and endocervical cancers167 -0.0490.529NS
COADColon adenocarcinoma445 -0.0110.811NS
ESCAEsophageal carcinoma162 -0.0990.209NS
HNSCHead and Neck squamous cell carcinoma448 0.0270.575NS
KIRCKidney renal clear cell carcinoma531 0.0610.16NS
KIRPKidney renal papillary cell carcinoma260 -0.2418.6e-05Lower
LIHCLiver hepatocellular carcinoma347 -0.030.577NS
LUADLung adenocarcinoma507 -0.1460.000969Lower
LUSCLung squamous cell carcinoma497 0.0490.277NS
OVOvarian serous cystadenocarcinoma302 0.0120.838NS
PAADPancreatic adenocarcinoma176 -0.0090.908NS
READRectum adenocarcinoma156 0.010.902NS
SKCMSkin Cutaneous Melanoma410 -0.0110.817NS
STADStomach adenocarcinoma392 0.0520.306NS
TGCTTesticular Germ Cell Tumors81 -0.3290.00271Lower
THCAThyroid carcinoma499 0.0370.405NS
UCECUterine Corpus Endometrial Carcinoma501 0.0570.205NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 -0.0650.287NS
HNSCHead and Neck squamous cell carcinoma498 -0.0310.497NS
KIRCKidney renal clear cell carcinoma525 -0.0390.371NS
LGGBrain Lower Grade Glioma514 -0.0590.183NS
LIHCLiver hepatocellular carcinoma366 -0.0370.482NS
OVOvarian serous cystadenocarcinoma296 0.0120.833NS
PAADPancreatic adenocarcinoma176 -0.1130.134NS
STADStomach adenocarcinoma406 -0.0630.203NS
UCECUterine Corpus Endometrial Carcinoma534 0.0930.0315Higher
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for VCPKMT.
Summary
SymbolVCPKMT
Namevalosin containing protein lysine methyltransferase
Aliases VCP-KMT; C14orf138; METTL21D; chromosome 14 open reading frame 138; methyltransferase like 21D; VCP lysine m ......
Location14q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for VCPKMT.
> Interactions from Text Mining
 
There is no record for VCPKMT.