CR2Cancer

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00651 BTB/POZ domain

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor, Histone modification erase cofactor	Histone acetylation, Histone methylation	CG, mCG, DNA motif	#	14527417

> Gene Ontology [ TOP ]
Biological Process	GO:0016055 Wnt signaling pathway GO:0198738 cell-cell signaling by wnt
Molecular Function	GO:0008327 methyl-CpG binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1741097	c.578_579insTTG	p.D193_D194insC	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM5607220	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM2723784	c.1748T>G	p.L583R	Substitution - Missense	Large_intestine
COSM1497183	c.101T>C	p.V34A	Substitution - Missense	Kidney
COSM1114019	c.228G>T	p.E76D	Substitution - Missense	Endometrium
COSM5445901	c.568_569insGTG	p.D189_D190insG	Insertion - In frame	Thyroid
COSM216176	c.168C>A	p.Y56*	Substitution - Nonsense	Central_nervous_system
COSM3964636	c.1050C>T	p.V350V	Substitution - coding silent	Lung
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1465247	c.587delT	p.C198fs*43	Deletion - Frameshift	Large_intestine
COSM3719939	c.1180delA	p.I394fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5607220	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM4507545	c.749C>T	p.P250L	Substitution - Missense	Skin
COSM1114032	c.1589T>C	p.V530A	Substitution - Missense	Endometrium
COSM165656	c.762T>A	p.N254K	Substitution - Missense	Breast
COSM1114027	c.987G>A	p.E329E	Substitution - coding silent	Endometrium
COSM5644933	c.1527G>T	p.L509F	Substitution - Missense	Oesophagus
COSM1114033	c.1595C>T	p.P532L	Substitution - Missense	Endometrium
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM5447879	c.174T>C	p.H58H	Substitution - coding silent	Large_intestine
COSM1114038	c.1914G>T	p.M638I	Substitution - Missense	Endometrium
COSM1114026	c.922T>G	p.L308V	Substitution - Missense	Endometrium
COSM85241	c.954T>C	p.S318S	Substitution - coding silent	Pancreas
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM4186986	c.1748T>A	p.L583H	Substitution - Missense	Kidney
COSM5487297	c.85G>T	p.G29*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1114022	c.559G>A	p.D187N	Substitution - Missense	Endometrium
COSM4377010	c.1707A>G	p.I569M	Substitution - Missense	Large_intestine
COSM1114025	c.911C>G	p.S304C	Substitution - Missense	Endometrium
COSM4904598	c.1876C>T	p.P626S	Substitution - Missense	Skin
COSM1737066	c.8G>A	p.S3N	Substitution - Missense	Central_nervous_system
COSM3843404	c.1673C>A	p.S558Y	Substitution - Missense	Breast
COSM5419217	c.277G>A	p.V93I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1465255	c.1972A>G	p.T658A	Substitution - Missense	Large_intestine
COSM2723784	c.1748T>G	p.L583R	Substitution - Missense	Large_intestine
COSM5644932	c.1522A>G	p.S508G	Substitution - Missense	Oesophagus
COSM456627	c.2014_2015insTA	p.Y672fs*>2	Insertion - Frameshift	Breast
COSM4106225	c.203T>C	p.V68A	Substitution - Missense	Stomach
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Central_nervous_system
COSM324355	c.1687C>T	p.Q563*	Substitution - Nonsense	Lung
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM3557312	c.1772C>T	p.S591F	Substitution - Missense	Skin
COSM755631	c.691C>A	p.P231T	Substitution - Missense	Lung
COSM1114028	c.1003A>G	p.I335V	Substitution - Missense	Endometrium
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1114021	c.450G>T	p.Q150H	Substitution - Missense	Endometrium
COSM5587019	c.1354C>T	p.P452S	Substitution - Missense	Skin
COSM3843403	c.1651C>T	p.Q551*	Substitution - Nonsense	Breast
COSM1741099	c.585_586insTGT	p.V195_I196insC	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1114034	c.1609C>T	p.R537C	Substitution - Missense	Endometrium
COSM1465253	c.1569G>T	p.P523P	Substitution - coding silent	Large_intestine
COSM3774021	c.584T>A	p.V195D	Substitution - Missense	Kidney
COSM5419432	c.1312G>A	p.G438S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4850664	c.1634C>T	p.T545I	Substitution - Missense	Cervix
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1114031	c.1569G>A	p.P523P	Substitution - coding silent	Endometrium
COSM1744772	c.474T>G	p.D158E	Substitution - Missense	Biliary_tract
COSM4548962	c.460G>C	p.D154H	Substitution - Missense	Skin
COSM1114035	c.1701A>G	p.S567S	Substitution - coding silent	Endometrium
COSM5693909	c.1367A>T	p.E456V	Substitution - Missense	Soft_tissue
COSM3557313	c.1883G>A	p.G628E	Substitution - Missense	Skin
COSM5703381	c.1392delA	p.T466fs*11	Deletion - Frameshift	Autonomic_ganglia
COSM1114018	c.122G>A	p.R41Q	Substitution - Missense	Endometrium
COSM1315150	c.58A>T	p.N20Y	Substitution - Missense	Urinary_tract
COSM3728748	c.1407C>T	p.S469S	Substitution - coding silent	Stomach
COSM5960098	c.1180A>T	p.I394L	Substitution - Missense	Thyroid
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM270575	c.47G>A	p.G16D	Substitution - Missense	Large_intestine
COSM216176	c.168C>A	p.Y56*	Substitution - Nonsense	Central_nervous_system
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Central_nervous_system
COSM1665064	c.708C>G	p.N236K	Substitution - Missense	Kidney
COSM2723765	c.1284G>A	p.S428S	Substitution - coding silent	Large_intestine
COSM4106226	c.281G>C	p.R94T	Substitution - Missense	Stomach
COSM5607220	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM4106227	c.526G>A	p.E176K	Substitution - Missense	Stomach
COSM3694307	c.591T>G	p.F197L	Substitution - Missense	Large_intestine
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1741095	c.581_582insCTG	p.D194_V195insC	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM73333	c.775A>G	p.S259G	Substitution - Missense	Ovary
COSM3363784	c.1252T>A	p.L418I	Substitution - Missense	Kidney
COSM1741155	c.577_578insTAT	p.D193>VY	Complex - insertion inframe	Haematopoietic_and_lymphoid_tissue
COSM3992320	c.76C>T	p.R26C	Substitution - Missense	Kidney
COSM1465251	c.956C>T	p.A319V	Substitution - Missense	Large_intestine
COSM1465250	c.939G>A	p.Q313Q	Substitution - coding silent	Large_intestine
COSM117269	c.620C>A	p.T207N	Substitution - Missense	Ovary
COSM4742125	c.1789T>C	p.Y597H	Substitution - Missense	Large_intestine
COSM1465252	c.1056T>C	p.N352N	Substitution - coding silent	Large_intestine
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM5487297	c.85G>T	p.G29*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Central_nervous_system
COSM3424402	c.1311C>T	p.I437I	Substitution - coding silent	Large_intestine
COSM1741096	c.569_570insNTG	p.D190>XC	Complex - insertion inframe	Haematopoietic_and_lymphoid_tissue
COSM5695248	c.339A>T	p.I113I	Substitution - coding silent	Soft_tissue
COSM2723784	c.1748T>G	p.L583R	Substitution - Missense	Large_intestine
COSM1270711	c.510T>C	p.S170S	Substitution - coding silent	Oesophagus
COSM3390393	c.421G>T	p.D141Y	Substitution - Missense	Pancreas
COSM4742123	c.1520C>T	p.T507I	Substitution - Missense	Large_intestine
COSM367586	c.1847G>T	p.G616V	Substitution - Missense	Lung
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM2723751	c.12A>C	p.R4S	Substitution - Missense	Large_intestine
COSM5699496	c.132G>C	p.R44R	Substitution - coding silent	Soft_tissue
COSM165655	c.1039G>C	p.D347H	Substitution - Missense	Breast
COSM5427256	c.112G>A	p.V38M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM130277	c.1283C>T	p.S428L	Substitution - Missense	Upper_aerodigestive_tract
COSM4742124	c.1625T>A	p.I542N	Substitution - Missense	Large_intestine
COSM202338	c.1048G>A	p.V350I	Substitution - Missense	Central_nervous_system
COSM1114024	c.832C>A	p.P278T	Substitution - Missense	Endometrium
COSM3800373	c.435G>A	p.K145K	Substitution - coding silent	Urinary_tract
COSM6018707	c.1230G>T	p.M410I	Substitution - Missense	Skin
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Central_nervous_system
COSM4945104	c.26C>G	p.A9G	Substitution - Missense	Liver
COSM5949393	c.1123A>T	p.M375L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3557311	c.1753C>T	p.R585C	Substitution - Missense	Skin
COSM1114036	c.1803C>T	p.S601S	Substitution - coding silent	Endometrium
COSM3557309	c.1596T>C	p.P532P	Substitution - coding silent	Skin
COSM1465254	c.1955T>A	p.I652N	Substitution - Missense	Large_intestine
COSM4106229	c.1529G>A	p.R510Q	Substitution - Missense	Stomach
COSM3913273	c.1163C>T	p.S388F	Substitution - Missense	Skin
COSM26961	c.598G>A	p.E200K	Substitution - Missense	Skin
COSM1114016	c.13A>C	p.K5Q	Substitution - Missense	Endometrium
COSM1114020	c.335T>A	p.F112Y	Substitution - Missense	Endometrium
COSM4610146	c.1262C>T	p.A421V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4106231	c.1814G>A	p.S605N	Substitution - Missense	Stomach
COSM2723766	c.1323T>G	p.T441T	Substitution - coding silent	Large_intestine
COSM202338	c.1048G>A	p.V350I	Substitution - Missense	Central_nervous_system
COSM5607220	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1741153	c.574_575insAAT	p.D192>EY	Complex - insertion inframe	Haematopoietic_and_lymphoid_tissue
COSM85241	c.954T>C	p.S318S	Substitution - coding silent	Breast
COSM5607220	c.1942G>A	p.E648K	Substitution - Missense	Skin
COSM3843402	c.1009G>A	p.D337N	Substitution - Missense	Breast
COSM4838115	c.1398G>T	p.T466T	Substitution - coding silent	Cervix
COSM4106228	c.1105G>T	p.G369*	Substitution - Nonsense	Stomach
COSM3720430	c.110T>C	p.I37T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1114030	c.1172T>G	p.I391S	Substitution - Missense	Endometrium
COSM1114017	c.42C>A	p.Y14*	Substitution - Nonsense	Endometrium
COSM383674	c.432C>T	p.D144D	Substitution - coding silent	Lung
COSM4843943	c.1673C>T	p.S558F	Substitution - Missense	Cervix
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM5622205	c.1129A>G	p.I377V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1741154	c.580_581insTAT	p.D194>VY	Complex - insertion inframe	Haematopoietic_and_lymphoid_tissue
COSM4106230	c.1753C>G	p.R585G	Substitution - Missense	Stomach
COSM1114037	c.1887C>T	p.T629T	Substitution - coding silent	Endometrium
COSM26961	c.598G>A	p.E200K	Substitution - Missense	Upper_aerodigestive_tract
COSM3557308	c.1175C>T	p.S392L	Substitution - Missense	Skin
COSM1465246	c.563_564insTGA	p.D194_V195insD	Insertion - In frame	Upper_aerodigestive_tract
COSM1114029	c.1060T>C	p.S354P	Substitution - Missense	Endometrium
COSM5446592	c.578_579insCGA	p.D194_V195insD	Insertion - In frame	Thyroid
COSM367800	c.1231G>T	p.E411*	Substitution - Nonsense	Lung
COSM4459628	c.1133C>T	p.P378L	Substitution - Missense	Skin
COSM1114023	c.656C>A	p.S219Y	Substitution - Missense	Endometrium
COSM1490422	c.1872A>C	p.E624D	Substitution - Missense	Breast
COSM1319528	c.230T>A	p.I77N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3557310	c.1700C>T	p.S567L	Substitution - Missense	Skin
COSM356350	c.1408G>T	p.E470*	Substitution - Nonsense	Lung

> Text Mining based Variations [ TOP ]
There is no record for ZBTB33.

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.455	5.086	0.727	5.21e-07	Over
BRCA	Breast invasive carcinoma	112	1100	5.827	5.667	-0.148	0.0206	NS
CESC	Cervical and endocervical cancers	3	306	4.382	5.331	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.593	5.217	0.62	1.45e-08	Over
ESCA	Esophageal carcinoma	11	185	5.448	5.949	0.608	0.000967	Over
GBM	Glioblastoma multiforme	5	166	5.098	5.593	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.145	5.173	0.136	0.171	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.975	4.951	-0.068	0.305	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.53	4.542	0.054	0.574	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.099	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.637	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.786	4.941	0.177	0.152	NS
LUAD	Lung adenocarcinoma	59	517	5.111	5.256	0.176	0.00879	NS
LUSC	Lung squamous cell carcinoma	51	501	4.838	5.605	0.709	1.14e-17	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.811	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.02	4.764	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.601	4.579	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.962	5.021	0.119	0.0716	NS
READ	Rectum adenocarcinoma	10	167	4.552	5.32	0.701	0.00537	Over
SARC	Sarcoma	2	263	3.851	4.483	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.487	5.383	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.683	5.556	0.794	2.05e-14	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.324	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.147	5.775	0.593	1.36e-18	Over
THYM	Thymoma	2	120	5.309	5.259	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.692	4.948	0.215	0.0605	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	7.3
Adrenal gland	9.4
Appendix	11.9
Bone marrow	12.9
Breast	19
Cerebral cortex	16.9
Cervix, uterine	10.9
Colon	7
Duodenum	8.2
Endometrium	10.6
Epididymis	11.3
Esophagus	11.5
Fallopian tube	13.5
Gallbladder	12.2
Heart muscle	3.4
Kidney	7
Liver	10.2
Lung	13.2
Lymph node	15.8
Ovary	12.3
Pancreas	1.8
Parathyroid gland	23
Placenta	12.8
Prostate	12.1
Rectum	7.4
Salivary gland	4.4
Seminal vesicle	8.4
Skeletal muscle	1.9
Skin	22.7
Small intestine	7.7
Smooth muscle	7.4
Spleen	16.4
Stomach	8.2
Testis	11.1
Thyroid gland	17.4
Tonsil	12.5
Urinary bladder	11

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26999717	Overexpression	Triple-Negative Breast Carcinoma	In this study, we report that the novel POZ-ZF transcription factor Kaiso is highly expressed in TNBCs and correlates with a shorter metastasis-free survival.
24570268	Overexpression	Invasive ductal carcinoma	In IDCs, there was higher Kaiso expression in both the cytoplasmic and nuclear compartments, which correlated with age <48 (cytoplasmic p < 0.0093; nuclear p < 0.0001) and moderate differentiation (cytoplasmic p < 0.0042; nuclear p < 0.0001), as determined by Chi square analysis.
22662240	Overexpression	Invasive ductal carcinoma; Breast Carcinoma	Nuclear Kaiso was predominantly found in invasive ductal carcinoma (IDC) (p=0.007), while cytoplasmic Kaiso expression was linked to invasive lobular carcinoma (ILC) (p=0.006). Although cytoplasmic Kaiso did not correlate to clinicopathological features, we found a significant correlation between nuclear Kaiso, high histological grade (p=0.023), ERα negativity (p=0.001), and the HER2-driven and basal/triple-negative breast cancers (p=0.018). Interestingly, nuclear Kaiso was also abundant in BRCA1-associated breast cancer (p<0.001) and invasive breast cancer overexpressing EGFR (p=0.019).
21070476	Overexpression	Lung Carcinoma	Since δ-catenin is upregulated in human lung cancer, the effects of δ-catenin overexpression in lung cancer still need to be clarified. Immunohistochemistry was performed to investigate the expression of δ-catenin and Kaiso, a δ-catenin-binding transcription factor, in 151 lung cancer specimens. A correlation between cytoplasmic δ-catenin and Kaiso expression was also associated with high TNM stage, lymph node metastases and poor prognosis. Co-immunoprecipitation assay confirmed the interactions of δ-catenin and Kaiso in lung cancer cells.
19615783	Overexpression	Lung Carcinoma	Cytoplasmic Kaiso expression was correlated with cytoplasmic p120ctn, they formed Kaiso-p120ctn complex in lung cancer tissues and cell lines. In addition, p120ctn ablation and overexpression altered Kaiso subcellular localization and protein level.

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.171	0.000577	19.1	66.1	14.9	Neutral
BRCA	Breast invasive carcinoma	1075	0.16	1.28e-07	18.2	67.9	13.9	Neutral
CESC	Cervical and endocervical cancers	292	0.257	8.95e-06	20.5	63	16.4	Neutral
COAD	Colon adenocarcinoma	449	0.072	0.126	11.4	69.9	18.7	Neutral
ESCA	Esophageal carcinoma	183	0.436	6.76e-10	14.2	53.6	32.2	Neutral
GBM	Glioblastoma multiforme	147	-0.111	0.182	22.4	72.8	4.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.278	1.37e-10	11.9	64.6	23.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.024	0.579	9.1	85.7	5.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.258	9.1e-06	10.4	56.2	33.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.556	7.85e-15	4.2	95.2	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.101	0.0217	15.2	76.6	8.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.298	6.38e-09	16.8	63.5	19.8	Neutral
LUAD	Lung adenocarcinoma	512	0.254	5.2e-09	10.5	65.8	23.6	Neutral
LUSC	Lung squamous cell carcinoma	498	0.326	9.36e-14	19.3	58.6	22.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.4	5.93e-13	39.7	30.3	30	Loss
PAAD	Pancreatic adenocarcinoma	177	0.158	0.0356	9	81.4	9.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	-0.249	0.00143	31.5	65.4	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.048	0.284	6.1	91.2	2.6	Neutral
READ	Rectum adenocarcinoma	164	0.153	0.05	16.5	62.8	20.7	Neutral
SARC	Sarcoma	255	0.369	1.27e-09	49.4	41.6	9	Loss
SKCM	Skin Cutaneous Melanoma	367	-0.001	0.977	24.5	61.9	13.6	Neutral
STAD	Stomach adenocarcinoma	413	0.347	3.9e-13	10.7	73.4	16	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.223	0.00614	18.7	65.3	16	Neutral
THCA	Thyroid carcinoma	497	-0.015	0.74	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.521	1.21e-09	4.2	91.6	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.076	0.0766	13.6	72.6	13.8	Neutral

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.277	7.08e-09	17	408	-0.063	0.0102	NS/NA
BRCA	Breast invasive carcinoma	-0.168	6.81e-07	83	785	-0.023	0.000201	NS/NA
CESC	Cervical and endocervical cancers	-0.21	0.000202	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.349	2.46e-10	19	297	0.014	0.435	NS/NA
ESCA	Esophageal carcinoma	-0.333	2.44e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.062	0.624	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.209	9.49e-07	20	522	-0.003	0.691	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.112	0.0381	24	319	0.01	0.411	NS/NA
KIRP	Kidney renal papillary cell carcinoma	0.045	0.442	23	275	0.018	0.467	NS/NA
LAML	Acute Myeloid Leukemia	-0.096	0.212	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.133	0.00223	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.208	2.14e-05	41	373	0.006	0.0712	NS/NA
LUAD	Lung adenocarcinoma	-0.134	0.00348	21	456	0.089	0.658	NS/NA
LUSC	Lung squamous cell carcinoma	-0.187	0.000256	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.433	0.25	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.059	0.43	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.263	0.000292	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.327	1.19e-14	35	498	0.004	5.93e-09	NS/NA
READ	Rectum adenocarcinoma	-0.372	0.000141	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.148	0.0162	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.16	0.000487	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.153	0.00309	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.167	0.0368	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.053	0.211	50	509	-0.038	0.124	NS/NA
THYM	Thymoma	-0.047	0.61	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.27	3.78e-09	34	431	-0.016	2.11e-09	NS/NA

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.622	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00167	Significant	23000897
COAD	Colon adenocarcinoma	149	0.218	NS	22810696
GBM	Glioblastoma multiforme	157	0.0351	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.16e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.491	NS	26536169
LGG	Brain Lower Grade Glioma	513	7.76e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.884	NS	25079552
LUSC	Lung squamous cell carcinoma	178	6.91e-11	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	9.33e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00267	Significant	26544944
READ	Rectum adenocarcinoma	67	0.285	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.949	NS	26091043
STAD	Stomach adenocarcinoma	277	0.000767	Significant	25079317
THCA	Thyroid carcinoma	391	7.47e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00161	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.688	0.073	NS
BRCA	Breast invasive carcinoma	1079	1.679	0.0203	Shorter
CESC	Cervical and endocervical cancers	291	0.787	0.472	NS
COAD	Colon adenocarcinoma	439	1	0.999	NS
ESCA	Esophageal carcinoma	184	1.643	0.136	NS
GBM	Glioblastoma multiforme	158	0.649	0.0857	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.158	0.465	NS
KIRC	Kidney renal clear cell carcinoma	531	0.581	0.00806	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.363	0.0295	Shorter
LAML	Acute Myeloid Leukemia	149	1.033	0.91	NS
LGG	Brain Lower Grade Glioma	511	1.2	0.462	NS
LIHC	Liver hepatocellular carcinoma	365	1.116	0.663	NS
LUAD	Lung adenocarcinoma	502	0.918	0.684	NS
LUSC	Lung squamous cell carcinoma	494	0.823	0.312	NS
OV	Ovarian serous cystadenocarcinoma	303	1.187	0.406	NS
PAAD	Pancreatic adenocarcinoma	177	1.167	0.582	NS
PCPG	Pheochromocytoma and Paraganglioma	179	659025212.796	0.0688	NS
PRAD	Prostate adenocarcinoma	497	0.772	0.737	NS
READ	Rectum adenocarcinoma	159	0.742	0.638	NS
SARC	Sarcoma	259	2.014	0.0127	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.846	0.38	NS
STAD	Stomach adenocarcinoma	388	0.871	0.541	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.497	0.256	NS
THYM	Thymoma	119	0.929	0.941	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.007	0.021	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.106	0.0335	Lower
BRCA	Breast invasive carcinoma	1071	-0.005	0.877	NS
CESC	Cervical and endocervical cancers	167	0.029	0.705	NS
COAD	Colon adenocarcinoma	445	0.007	0.88	NS
ESCA	Esophageal carcinoma	162	0.011	0.886	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.028	0.55	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.107	0.0133	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.078	0.21	NS
LIHC	Liver hepatocellular carcinoma	347	-0.044	0.411	NS
LUAD	Lung adenocarcinoma	507	0.005	0.91	NS
LUSC	Lung squamous cell carcinoma	497	-0.051	0.255	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.022	0.705	NS
PAAD	Pancreatic adenocarcinoma	176	-0.042	0.577	NS
READ	Rectum adenocarcinoma	156	0.045	0.577	NS
SKCM	Skin Cutaneous Melanoma	410	0.06	0.225	NS
STAD	Stomach adenocarcinoma	392	0.039	0.442	NS
TGCT	Testicular Germ Cell Tumors	81	0.329	0.00268	Higher
THCA	Thyroid carcinoma	499	-0.008	0.86	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.069	0.12	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.064	0.289	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.058	0.198	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.103	0.018	Lower
LGG	Brain Lower Grade Glioma	514	0.06	0.171	NS
LIHC	Liver hepatocellular carcinoma	366	-0.119	0.0234	Lower
OV	Ovarian serous cystadenocarcinoma	296	0.011	0.85	NS
PAAD	Pancreatic adenocarcinoma	176	-0.053	0.481	NS
STAD	Stomach adenocarcinoma	406	-0.112	0.0244	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.225	1.45e-07	Higher

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ZBTB33.

Summary
Symbol	ZBTB33
Name	zinc finger and BTB domain containing 33
Aliases	ZNF-kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF348; kaiso transcription factor; zinc finger and BTB domain-contain ......
Location	Xq24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26999717	Triple-Negative Breast Carcinoma	upstream	TGFβ pathway	Positive regulation	Notably, Kaiso expression is induced by the TGFβ pathway and silencing Kaiso expression in the highly invasive breast cancer cell lines, MDA-MB-231 (hereafter MDA-231) and Hs578T, attenuated the expression of several EMT-associated proteins (Vimentin, Slug and ZEB1), abrogated TGFβ signaling and TGFβ-dependent EMT.
24570268	Invasive ductal carcinoma	partner	E-cadherin	Negative correlation	Immunofluorescence co-staining of poorly differentiated IDCs demonstrated that nuclear Kaiso is associated with a loss of E-cadherin expression.
21070476	Lung Carcinoma	upstream	δ-catenin	regulation	In addition, methylation-specific PCR and ChIP assay demonstrated that δ-catenin could regulate MTA2 via Kaiso in a methylation-dependent manner, while it could regulate cyclin D1 and MMP7 expression through Kaiso in a sequence-specific manner.
21070476	Lung Carcinoma	downstream	cyclin D1; NMP7	regulation	In addition, methylation-specific PCR and ChIP assay demonstrated that δ-catenin could regulate MTA2 via Kaiso in a methylation-dependent manner, while it could regulate cyclin D1 and MMP7 expression through Kaiso in a sequence-specific manner.
19615783	Lung Carcinoma	partner	p120ctn	Binding; positive correlation	Cytoplasmic Kaiso expression was correlated with cytoplasmic p120ctn, they formed Kaiso-p120ctn complex in lung cancer tissues and cell lines. In addition, p120ctn ablation and overexpression altered Kaiso subcellular localization and protein level.