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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-126-5p ABCA12 0.22 0.0501 -1.3 1.0E-5 mirMAP -0.27 0.01666 NA
2 hsa-miR-126-5p ABCB5 0.22 0.0501 0.03 0.9111 mirMAP -0.19 0.0485 NA
3 hsa-miR-130b-5p ABCC3 1.15 0 -1.19 0 mirMAP -0.43 0 NA
4 hsa-miR-126-5p ABCC9 0.22 0.0501 -1.23 0 mirMAP -0.14 0.04239 NA
5 hsa-miR-126-5p ABLIM1 0.22 0.0501 -0.73 0 mirMAP -0.14 0.00596 NA
6 hsa-miR-126-5p ACOT11 0.22 0.0501 -1.43 0 mirMAP -0.26 0.00012 NA
7 hsa-miR-130b-5p ACPP 1.15 0 0.1 0.70864 mirMAP -0.18 0.01854 NA
8 hsa-miR-130b-5p ACSL4 1.15 0 -1.19 0 MirTarget -0.33 0 NA
9 hsa-miR-130b-5p ADAM22 1.15 0 -1.06 1.0E-5 MirTarget -0.36 0 NA
10 hsa-miR-130b-5p ADAM23 1.15 0 -1.03 0 mirMAP -0.35 0 NA
11 hsa-miR-130b-5p ADAMTS12 1.15 0 -0.6 0.00161 mirMAP -0.21 6.0E-5 NA
12 hsa-miR-130b-5p ADAMTS5 1.15 0 -1.91 0 miRNATAP -0.43 0 NA
13 hsa-miR-130b-5p ADD2 1.15 0 0.23 0.38613 mirMAP -0.31 4.0E-5 NA
14 hsa-miR-130b-5p ADD3 1.15 0 -0.99 0 MirTarget; miRNATAP -0.22 0 NA
15 hsa-miR-130b-5p AFAP1 1.15 0 -0.34 4.0E-5 mirMAP -0.1 0 NA
16 hsa-miR-126-5p AFF2 0.22 0.0501 -1.9 0 mirMAP; miRNATAP -0.19 0.02483 NA
17 hsa-miR-130b-5p AFF2 1.15 0 -1.9 0 mirMAP -0.47 0 NA
18 hsa-miR-126-5p AGPAT4 0.22 0.0501 -0.67 0 mirMAP -0.15 0.00525 NA
19 hsa-miR-130b-5p AGPAT4 1.15 0 -0.67 0 mirMAP -0.34 0 NA
20 hsa-miR-126-5p AGPS 0.22 0.0501 -0.88 0 mirMAP -0.12 0.00851 NA
21 hsa-miR-126-5p AJAP1 0.22 0.0501 -1.01 0 mirMAP -0.19 0.02137 NA
22 hsa-miR-130b-5p AKAP2 1.15 0 -1.25 3.0E-5 mirMAP -0.33 7.0E-5 NA
23 hsa-miR-130b-5p AKAP6 1.15 0 -0.91 0 MirTarget -0.26 0 NA
24 hsa-miR-130b-5p ALDH1B1 1.15 0 -0.33 7.0E-5 miRNAWalker2 validate -0.15 0 NA
25 hsa-miR-126-5p ANGPTL1 0.22 0.0501 -1.94 0 mirMAP -0.19 0.04016 NA
26 hsa-miR-126-5p ANKDD1A 0.22 0.0501 -0.62 0 mirMAP -0.13 0.00215 NA
27 hsa-miR-126-5p ANKRD45 0.22 0.0501 -1.55 0 mirMAP -0.18 0.02109 NA
28 hsa-miR-130b-5p ANKRD50 1.15 0 0.05 0.63242 miRNATAP -0.14 0 NA
29 hsa-miR-130b-5p ANO5 1.15 0 -1.93 0 MirTarget -0.67 0 NA
30 hsa-miR-126-5p ANP32E 0.22 0.0501 -1.17 0 mirMAP -0.12 0.00914 NA
31 hsa-miR-126-5p ANTXR2 0.22 0.0501 -0.69 0 MirTarget -0.13 0.0064 NA
32 hsa-miR-130b-5p ANTXR2 1.15 0 -0.69 0 mirMAP; miRNATAP -0.17 0 NA
33 hsa-miR-126-5p APLF 0.22 0.0501 -0.91 0 mirMAP -0.17 0.00035 NA
34 hsa-miR-126-5p ARHGAP20 0.22 0.0501 -1.96 0 mirMAP -0.2 0.00836 NA
35 hsa-miR-130b-5p ARHGAP31 1.15 0 -0.55 0 mirMAP -0.16 0 NA
36 hsa-miR-130b-5p ARL10 1.15 0 -1.23 0 mirMAP -0.31 0 NA
37 hsa-miR-126-5p ARL4C 0.22 0.0501 -0.78 0 MirTarget; mirMAP; miRNATAP -0.15 0.00141 NA
38 hsa-miR-130b-5p ARL4C 1.15 0 -0.78 0 mirMAP; miRNATAP -0.29 0 NA
39 hsa-miR-126-5p ARL6IP6 0.22 0.0501 -0.24 0.00097 mirMAP -0.11 5.0E-5 NA
40 hsa-miR-126-5p ARRDC3 0.22 0.0501 -0.49 2.0E-5 mirMAP -0.16 0.00013 NA
41 hsa-miR-130b-5p ARRDC3 1.15 0 -0.49 2.0E-5 miRNATAP -0.26 0 NA
42 hsa-miR-126-5p ARSJ 0.22 0.0501 -1.03 0 mirMAP -0.3 0 NA
43 hsa-miR-130b-5p ASPH 1.15 0 -1.11 0 MirTarget -0.2 0 NA
44 hsa-miR-130b-5p ASTN1 1.15 0 -2.02 0 MirTarget -0.4 0 NA
45 hsa-miR-126-5p ATCAY 0.22 0.0501 -1.63 0 mirMAP -0.39 4.0E-5 NA
46 hsa-miR-130b-5p ATCAY 1.15 0 -1.63 0 mirMAP -0.65 0 NA
47 hsa-miR-130b-5p ATP10D 1.15 0 -0.76 0 mirMAP -0.25 0 NA
48 hsa-miR-126-5p ATP1B1 0.22 0.0501 -1.17 0 mirMAP -0.19 0.00037 NA
49 hsa-miR-130b-5p ATXN1 1.15 0 -0.46 2.0E-5 mirMAP -0.18 0 NA
50 hsa-miR-130b-5p AVPR2 1.15 0 -0.24 0.12825 mirMAP -0.11 0.014 NA
51 hsa-miR-126-5p B4GALT6 0.22 0.0501 -0.82 0 mirMAP -0.16 0.00016 NA
52 hsa-miR-130b-5p B4GALT6 1.15 0 -0.82 0 MirTarget -0.2 0 NA
53 hsa-miR-130b-5p BACH2 1.15 0 -0.74 0 mirMAP -0.23 0 NA
54 hsa-miR-126-5p BCL11A 0.22 0.0501 -1.44 0 mirMAP -0.38 2.0E-5 NA
55 hsa-miR-126-5p BCL2 0.22 0.0501 -1.2 0 mirMAP -0.2 0.00033 NA
56 hsa-miR-130b-5p BCL2 1.15 0 -1.2 0 mirMAP -0.29 0 27364335 The level of microRNA-130b in relationship with the expression of PPARĪ³ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARĪ³ up-regulation of VEGF-A and BCL-2 and decreased apoptosis
57 hsa-miR-130b-5p BCL6 1.15 0 -0.36 0.00062 MirTarget; miRNATAP -0.11 0.00012 NA
58 hsa-miR-126-5p BDH2 0.22 0.0501 -1.01 0 MirTarget -0.13 0.01144 NA
59 hsa-miR-130b-5p BDKRB2 1.15 0 -1.01 0 mirMAP -0.35 0 NA
60 hsa-miR-126-5p BEND6 0.22 0.0501 -0.83 0 mirMAP -0.16 0.0018 NA
61 hsa-miR-126-5p BHLHE41 0.22 0.0501 -0.25 0.10102 mirMAP -0.14 0.01183 NA
62 hsa-miR-130b-5p BMP7 1.15 0 -1.55 0 mirMAP -0.62 0 NA
63 hsa-miR-126-5p BNC2 0.22 0.0501 -1.29 0 mirMAP -0.16 0.01014 NA
64 hsa-miR-130b-5p BNC2 1.15 0 -1.29 0 miRNATAP -0.45 0 NA
65 hsa-miR-126-5p BVES 0.22 0.0501 -1.18 0 mirMAP -0.24 0.00055 NA
66 hsa-miR-126-5p C11orf45 0.22 0.0501 -1.74 0 miRNATAP -0.21 0.00181 NA
67 hsa-miR-130b-5p C17orf51 1.15 0 -0.61 0 mirMAP -0.15 0 NA
68 hsa-miR-126-5p C1D 0.22 0.0501 -0.11 0.12 mirMAP -0.16 0 NA
69 hsa-miR-130b-5p C1QTNF2 1.15 0 -0.59 0.00025 mirMAP -0.24 0 NA
70 hsa-miR-126-5p C1RL 0.22 0.0501 -0.17 0.13006 MirTarget -0.17 4.0E-5 NA
71 hsa-miR-130b-5p C1orf204 1.15 0 -0.88 0 miRNATAP -0.31 0 NA
72 hsa-miR-130b-5p C20orf194 1.15 0 -1.17 0 mirMAP -0.31 0 NA
73 hsa-miR-126-5p C2orf88 0.22 0.0501 -2.69 0 mirMAP -0.33 0.00015 NA
74 hsa-miR-126-5p C3orf58 0.22 0.0501 -0.39 6.0E-5 mirMAP -0.11 0.00392 NA
75 hsa-miR-126-5p C3orf70 0.22 0.0501 -1.44 0 mirMAP -0.25 9.0E-5 NA
76 hsa-miR-126-5p C9orf47 0.22 0.0501 -0.53 0.00074 mirMAP -0.19 0.0012 NA
77 hsa-miR-126-5p CACNB4 0.22 0.0501 -0.97 0 mirMAP -0.26 4.0E-5 NA
78 hsa-miR-126-5p CALD1 0.22 0.0501 -1.23 0 mirMAP -0.18 0.00025 NA
79 hsa-miR-130b-5p CAMK1D 1.15 0 -1.36 0 mirMAP -0.36 0 NA
80 hsa-miR-130b-5p CAMK2A 1.15 0 -1.67 0 mirMAP -0.34 0 NA
81 hsa-miR-130b-5p CAMK4 1.15 0 -1.01 0 mirMAP -0.37 0 NA
82 hsa-miR-130b-5p CBX6 1.15 0 -0.85 0 mirMAP -0.17 2.0E-5 NA
83 hsa-miR-130b-5p CCND2 1.15 0 -1.36 0 mirMAP -0.36 0 NA
84 hsa-miR-130b-5p CCNJL 1.15 0 -1.46 0 mirMAP -0.42 0 NA
85 hsa-miR-130b-5p CD93 1.15 0 -0.21 0.09856 mirMAP -0.14 0.00011 NA
86 hsa-miR-130b-5p CD99L2 1.15 0 -0.42 0 mirMAP -0.1 0 NA
87 hsa-miR-126-5p CDCA7 0.22 0.0501 -0.62 0.00061 MirTarget; miRNATAP -0.32 0 NA
88 hsa-miR-130b-5p CDCA7L 1.15 0 -0.54 0.0004 MirTarget -0.2 0 NA
89 hsa-miR-130b-5p CDH19 1.15 0 -1.61 0 MirTarget -0.52 0 NA
90 hsa-miR-130b-5p CDH23 1.15 0 -1.61 0 mirMAP -0.41 0 NA
91 hsa-miR-130b-5p CEACAM1 1.15 0 -0.52 0.00737 mirMAP -0.41 0 NA
92 hsa-miR-126-5p CELF2 0.22 0.0501 -1.12 0 mirMAP; miRNATAP -0.13 0.0247 NA
93 hsa-miR-130b-5p CERK 1.15 0 -1.2 0 mirMAP -0.25 0 NA
94 hsa-miR-126-5p CFL2 0.22 0.0501 -1.33 0 MirTarget; mirMAP -0.14 0.00243 NA
95 hsa-miR-130b-5p CGNL1 1.15 0 -0.15 0.12316 miRNAWalker2 validate; MirTarget -0.1 0.00014 NA
96 hsa-miR-130b-5p CHD1 1.15 0 -0.2 0.07933 miRNAWalker2 validate -0.15 0 NA
97 hsa-miR-126-5p CHL1 0.22 0.0501 -0.41 0.12478 mirMAP -0.22 0.03355 NA
98 hsa-miR-126-5p CHODL 0.22 0.0501 -0.6 0.01606 mirMAP -0.36 0.00013 NA
99 hsa-miR-126-5p CHRDL1 0.22 0.0501 -2.13 0 mirMAP -0.31 0.00049 NA
100 hsa-miR-130b-5p CHRDL1 1.15 0 -2.13 0 MirTarget; miRNATAP -0.67 0 NA
101 hsa-miR-130b-5p CHST3 1.15 0 -1.2 0 mirMAP -0.36 0 NA
102 hsa-miR-130b-5p CLIP3 1.15 0 -1.43 0 miRNATAP -0.41 0 NA
103 hsa-miR-126-5p CLIP4 0.22 0.0501 -1.23 0 mirMAP -0.22 2.0E-5 NA
104 hsa-miR-130b-5p CLVS2 1.15 0 -2.48 0 MirTarget -0.73 0 NA
105 hsa-miR-126-5p CNTN1 0.22 0.0501 -1.78 0 MirTarget -0.22 0.04692 NA
106 hsa-miR-126-5p CNTNAP3 0.22 0.0501 -0.45 0.01716 mirMAP -0.16 0.02394 NA
107 hsa-miR-130b-5p COL27A1 1.15 0 -1.35 0 mirMAP -0.47 0 NA
108 hsa-miR-130b-5p CPXM2 1.15 0 -0.05 0.77971 mirMAP -0.21 1.0E-5 NA
109 hsa-miR-126-5p CRYZ 0.22 0.0501 -0.84 0 mirMAP -0.13 0.00014 NA
110 hsa-miR-130b-5p CSRP1 1.15 0 -1.5 0 mirMAP -0.41 0 NA
111 hsa-miR-130b-5p CYBB 1.15 0 -0.14 0.39968 mirMAP -0.17 0.00025 NA
112 hsa-miR-130b-5p CYBRD1 1.15 0 -0.65 0 mirMAP -0.29 0 NA
113 hsa-miR-126-5p CYP24A1 0.22 0.0501 -1.49 0.00015 mirMAP -0.46 0.00209 NA
114 hsa-miR-130b-5p CYP26B1 1.15 0 -1.24 0 mirMAP -0.26 2.0E-5 NA
115 hsa-miR-130b-5p CYYR1 1.15 0 -0.69 0 MirTarget -0.16 0 NA
116 hsa-miR-126-5p DAB1 0.22 0.0501 -2.75 0 mirMAP -0.43 0.0004 NA
117 hsa-miR-126-5p DACH2 0.22 0.0501 -1.01 0.0039 mirMAP -0.31 0.01929 NA
118 hsa-miR-126-5p DCBLD2 0.22 0.0501 -0.76 0 mirMAP -0.13 0.00027 NA
119 hsa-miR-126-5p DCDC2 0.22 0.0501 -0.24 0.3307 MirTarget; mirMAP; miRNATAP -0.19 0.04947 NA
120 hsa-miR-130b-5p DENND5B 1.15 0 -0.49 3.0E-5 MirTarget -0.13 4.0E-5 NA
121 hsa-miR-130b-5p DIO2 1.15 0 0.21 0.177 miRNATAP -0.18 2.0E-5 NA
122 hsa-miR-130b-5p DIO3 1.15 0 -0.63 0.00012 mirMAP -0.3 0 NA
123 hsa-miR-126-5p DMD 0.22 0.0501 -1.67 0 MirTarget; mirMAP -0.16 0.02432 NA
124 hsa-miR-130b-5p DNAH3 1.15 0 -0.11 0.69134 mirMAP -0.18 0.02072 NA
125 hsa-miR-126-5p DNAJB4 0.22 0.0501 -1.41 0 mirMAP -0.16 0.00576 NA
126 hsa-miR-130b-5p DRP2 1.15 0 -0.6 0.00037 mirMAP -0.34 0 NA
127 hsa-miR-126-5p DSG3 0.22 0.0501 -1.91 0 mirMAP -0.4 0.00329 NA
128 hsa-miR-130b-5p DST 1.15 0 -1.08 0 mirMAP -0.34 0 NA
129 hsa-miR-130b-5p DTX4 1.15 0 -0.48 1.0E-5 mirMAP -0.19 0 NA
130 hsa-miR-126-5p DUSP19 0.22 0.0501 -1.15 0 mirMAP -0.16 7.0E-5 NA
131 hsa-miR-130b-5p DUSP3 1.15 0 -0.71 0 MirTarget -0.15 0 NA
132 hsa-miR-130b-5p EBF4 1.15 0 -0.47 0.00012 miRNATAP -0.22 0 NA
133 hsa-miR-126-5p EDA2R 0.22 0.0501 -1.15 0 MirTarget -0.17 0.00739 NA
134 hsa-miR-126-5p EDAR 0.22 0.0501 -2.05 0 mirMAP -0.56 0 NA
135 hsa-miR-130b-5p EDAR 1.15 0 -2.05 0 mirMAP -0.55 0 NA
136 hsa-miR-130b-5p EDN3 1.15 0 -2.3 0 mirMAP -0.69 0 NA
137 hsa-miR-126-5p EDNRA 0.22 0.0501 -1.35 0 mirMAP -0.24 0.00011 NA
138 hsa-miR-130b-5p EFNB1 1.15 0 -1.33 0 mirMAP; miRNATAP -0.26 0 NA
139 hsa-miR-130b-5p EGR3 1.15 0 -0.38 0.14781 mirMAP -0.32 1.0E-5 NA
140 hsa-miR-130b-5p EHD3 1.15 0 -0.26 0.00997 mirMAP -0.12 1.0E-5 NA
141 hsa-miR-130b-5p ELF3 1.15 0 0.05 0.76137 mirMAP -0.19 1.0E-5 NA
142 hsa-miR-126-5p EPHA3 0.22 0.0501 -0.73 8.0E-5 mirMAP -0.15 0.03152 NA
143 hsa-miR-126-5p EPHA5 0.22 0.0501 -1.46 1.0E-5 mirMAP -0.32 0.00776 NA
144 hsa-miR-126-5p EPHA7 0.22 0.0501 -0.61 0.00129 mirMAP; miRNATAP -0.3 2.0E-5 NA
145 hsa-miR-130b-5p EPHA7 1.15 0 -0.61 0.00129 miRNATAP -0.31 0 NA
146 hsa-miR-126-5p EPHB1 0.22 0.0501 -2.38 0 MirTarget -0.2 0.03078 NA
147 hsa-miR-126-5p ERAP1 0.22 0.0501 -0.61 0 mirMAP -0.11 0.00385 NA
148 hsa-miR-130b-5p ERBB4 1.15 0 -1.22 0 miRNATAP -0.21 0.00058 NA
149 hsa-miR-130b-5p ERC1 1.15 0 -0.63 0 mirMAP -0.12 0 NA
150 hsa-miR-130b-5p ESR1 1.15 0 -0.31 0.08775 mirMAP -0.33 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 89 1426 3.498e-15 1.628e-11
2 MORPHOGENESIS OF AN EPITHELIUM 41 400 4.785e-14 1.113e-10
3 NEURON PROJECTION DEVELOPMENT 48 545 1.003e-13 1.545e-10
4 MORPHOGENESIS OF A BRANCHING STRUCTURE 26 167 1.66e-13 1.545e-10
5 TISSUE DEVELOPMENT 89 1518 1.336e-13 1.545e-10
6 GLAND MORPHOGENESIS 20 97 4.772e-13 3.701e-10
7 TISSUE MORPHOGENESIS 46 533 6.96e-13 4.626e-10
8 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 91 1672 4.601e-12 2.676e-09
9 NEURON DEVELOPMENT 51 687 1.117e-11 4.727e-09
10 EPITHELIUM DEVELOPMENT 62 945 1.158e-11 4.727e-09
11 NEUROGENESIS 80 1402 1.128e-11 4.727e-09
12 NEURON DIFFERENTIATION 59 874 1.219e-11 4.727e-09
13 NEURON PROJECTION GUIDANCE 26 205 2.062e-11 7.382e-09
14 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 35 368 3.038e-11 1.01e-08
15 REGULATION OF CELL DIFFERENTIATION 82 1492 3.964e-11 1.153e-08
16 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 42 513 3.954e-11 1.153e-08
17 CELL PROJECTION ORGANIZATION 59 902 4.327e-11 1.184e-08
18 CARDIOVASCULAR SYSTEM DEVELOPMENT 54 788 5.58e-11 1.333e-08
19 CIRCULATORY SYSTEM DEVELOPMENT 54 788 5.58e-11 1.333e-08
20 BIOLOGICAL ADHESION 64 1032 5.731e-11 1.333e-08
21 NEURON PROJECTION MORPHOGENESIS 36 402 8.711e-11 1.93e-08
22 TUBE DEVELOPMENT 43 552 1.125e-10 2.379e-08
23 VASCULATURE DEVELOPMENT 39 469 1.283e-10 2.595e-08
24 DEVELOPMENTAL GROWTH 32 333 1.673e-10 3.244e-08
25 ORGAN MORPHOGENESIS 54 841 6.058e-10 1.084e-07
26 GROWTH 35 410 5.855e-10 1.084e-07
27 GLAND DEVELOPMENT 34 395 8.364e-10 1.441e-07
28 CELLULAR COMPONENT MORPHOGENESIS 56 900 9.045e-10 1.503e-07
29 TUBE MORPHOGENESIS 30 323 1.422e-09 2.282e-07
30 BLOOD VESSEL MORPHOGENESIS 32 364 1.579e-09 2.385e-07
31 ORGAN GROWTH 14 68 1.589e-09 2.385e-07
32 STEM CELL DIFFERENTIATION 22 190 4.164e-09 6.055e-07
33 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 63 1142 8.454e-09 1.192e-06
34 MESENCHYMAL CELL DIFFERENTIATION 18 134 1.04e-08 1.423e-06
35 TAXIS 35 464 1.468e-08 1.952e-06
36 MESENCHYME DEVELOPMENT 21 190 2.15e-08 2.778e-06
37 LOCOMOTION 60 1114 4.675e-08 5.879e-06
38 CELL PART MORPHOGENESIS 41 633 6.26e-08 7.665e-06
39 POSITIVE REGULATION OF CELL PROLIFERATION 48 814 8.151e-08 9.725e-06
40 POSITIVE REGULATION OF GENE EXPRESSION 81 1733 9.011e-08 1.048e-05
41 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 53 957 1.266e-07 1.435e-05
42 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 45 750 1.295e-07 1.435e-05
43 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 82 1805 2.461e-07 2.664e-05
44 UROGENITAL SYSTEM DEVELOPMENT 25 299 2.591e-07 2.708e-05
45 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 16 131 2.619e-07 2.708e-05
46 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 14 104 4.399e-07 4.449e-05
47 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 63 1275 4.556e-07 4.51e-05
48 CELL CELL ADHESION 38 608 4.717e-07 4.573e-05
49 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 54 1036 6.492e-07 6.041e-05
50 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 54 1036 6.492e-07 6.041e-05
51 REGULATION OF CELLULAR COMPONENT MOVEMENT 44 771 7.095e-07 6.473e-05
52 REGULATION OF CELL PROLIFERATION 70 1496 7.403e-07 6.624e-05
53 MUSCLE TISSUE DEVELOPMENT 23 275 7.767e-07 6.819e-05
54 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 53 1021 9.402e-07 8.101e-05
55 SALIVARY GLAND DEVELOPMENT 8 32 1.101e-06 9.148e-05
56 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 66 1395 1.092e-06 9.148e-05
57 MORPHOGENESIS OF AN EPITHELIAL FOLD 6 15 1.15e-06 9.388e-05
58 PROSTATE GLAND MORPHOGENESIS 7 23 1.219e-06 9.781e-05
59 REGULATION OF EPITHELIAL CELL PROLIFERATION 23 285 1.441e-06 0.0001117
60 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 10 56 1.419e-06 0.0001117
61 HEART DEVELOPMENT 31 466 1.518e-06 0.0001158
62 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 41 724 2.09e-06 0.0001568
63 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 56 1135 2.199e-06 0.0001624
64 REGULATION OF MUSCLE TISSUE DEVELOPMENT 13 103 2.382e-06 0.0001732
65 BRANCH ELONGATION OF AN EPITHELIUM 6 17 2.722e-06 0.0001948
66 MUSCLE STRUCTURE DEVELOPMENT 29 432 2.77e-06 0.0001953
67 KIDNEY EPITHELIUM DEVELOPMENT 14 125 4.142e-06 0.0002876
68 MUSCLE SYSTEM PROCESS 22 282 4.227e-06 0.0002892
69 POSITIVE REGULATION OF MAPK CASCADE 30 470 5.126e-06 0.0003457
70 REGULATION OF CELL DEVELOPMENT 44 836 5.858e-06 0.0003894
71 REGULATION OF PROTEIN MODIFICATION PROCESS 74 1710 6.095e-06 0.0003994
72 EPIDERMIS MORPHOGENESIS 7 29 6.79e-06 0.0004328
73 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 7 29 6.79e-06 0.0004328
74 REGULATION OF CELL ADHESION 36 629 7.035e-06 0.0004423
75 MESONEPHRIC TUBULE MORPHOGENESIS 9 53 7.39e-06 0.0004524
76 HEAD DEVELOPMENT 39 709 7.373e-06 0.0004524
77 REGULATION OF NEURON DIFFERENTIATION 33 554 7.505e-06 0.0004535
78 APPENDAGE DEVELOPMENT 16 169 7.858e-06 0.000457
79 LIMB DEVELOPMENT 16 169 7.858e-06 0.000457
80 ANGIOGENESIS 22 293 7.803e-06 0.000457
81 PROSTATE GLAND DEVELOPMENT 8 41 8.161e-06 0.0004607
82 NEPHRON DEVELOPMENT 13 115 8.218e-06 0.0004607
83 LUNG ALVEOLUS DEVELOPMENT 8 41 8.161e-06 0.0004607
84 POSITIVE REGULATION OF CELL DIFFERENTIATION 43 823 8.983e-06 0.0004976
85 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 14 135 1.02e-05 0.0005584
86 RESPONSE TO WOUNDING 33 563 1.047e-05 0.0005664
87 RESPIRATORY SYSTEM DEVELOPMENT 17 197 1.414e-05 0.0007564
88 CARDIAC MUSCLE TISSUE DEVELOPMENT 14 140 1.55e-05 0.0008193
89 RESPONSE TO EXTERNAL STIMULUS 76 1821 1.614e-05 0.0008437
90 LUNG MORPHOGENESIS 8 45 1.682e-05 0.0008509
91 EXOCRINE SYSTEM DEVELOPMENT 8 45 1.682e-05 0.0008509
92 CENTRAL NERVOUS SYSTEM DEVELOPMENT 44 872 1.665e-05 0.0008509
93 REGULATION OF ORGAN MORPHOGENESIS 19 242 1.732e-05 0.0008664
94 MESONEPHROS DEVELOPMENT 11 90 1.934e-05 0.0009571
95 NEGATIVE REGULATION OF CELL DIFFERENTIATION 34 609 2.116e-05 0.001024
96 REGULATION OF PHOSPHORUS METABOLIC PROCESS 69 1618 2.105e-05 0.001024
97 NEURAL CREST CELL DIFFERENTIATION 10 75 2.136e-05 0.001024
98 REGULATION OF CELL PROJECTION ORGANIZATION 32 558 2.195e-05 0.001042
99 REGULATION OF NEURON PROJECTION DEVELOPMENT 26 408 2.24e-05 0.001053
100 POSITIVE REGULATION OF CELL COMMUNICATION 66 1532 2.371e-05 0.001103
101 NEPHRON EPITHELIUM DEVELOPMENT 11 93 2.644e-05 0.001218
102 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 8 48 2.753e-05 0.001242
103 CELL MOTILITY 42 835 2.802e-05 0.001242
104 LOCALIZATION OF CELL 42 835 2.802e-05 0.001242
105 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 48 1004 2.741e-05 0.001242
106 INTRACELLULAR SIGNAL TRANSDUCTION 67 1572 2.861e-05 0.001256
107 RENAL TUBULE DEVELOPMENT 10 78 3.026e-05 0.001316
108 REGULATION OF TRANSPORT 74 1804 3.763e-05 0.001621
109 BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS 5 16 3.798e-05 0.001621
110 REGULATION OF HOMEOSTATIC PROCESS 27 447 3.983e-05 0.001685
111 POSITIVE REGULATION OF ORGAN GROWTH 7 38 4.494e-05 0.001884
112 REGULATION OF MAPK CASCADE 35 660 4.618e-05 0.001919
113 KIDNEY MORPHOGENESIS 10 82 4.695e-05 0.001933
114 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 16 197 5.263e-05 0.002111
115 POSITIVE REGULATION OF HEART GROWTH 6 27 5.231e-05 0.002111
116 AXIS ELONGATION 6 27 5.231e-05 0.002111
117 NEGATIVE CHEMOTAXIS 7 39 5.357e-05 0.00213
118 REGULATION OF SYSTEM PROCESS 29 507 5.561e-05 0.002193
119 SINGLE ORGANISM CELL ADHESION 27 459 6.252e-05 0.002445
120 REGULATION OF DEVELOPMENTAL GROWTH 20 289 6.363e-05 0.002446
121 EMBRYO DEVELOPMENT 43 894 6.338e-05 0.002446
122 REGULATION OF JNK CASCADE 14 159 6.414e-05 0.002446
123 SECOND MESSENGER MEDIATED SIGNALING 14 160 6.867e-05 0.002578
124 REGULATION OF MUSCLE ORGAN DEVELOPMENT 11 103 6.87e-05 0.002578
125 INOSITOL PHOSPHATE MEDIATED SIGNALING 5 18 7.139e-05 0.002658
126 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 6 29 8.036e-05 0.002968
127 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 72 1784 8.1e-05 0.002968
128 REGULATION OF HEART GROWTH 7 42 8.791e-05 0.003196
129 PATTERN SPECIFICATION PROCESS 25 418 8.941e-05 0.003225
130 CARDIAC CHAMBER DEVELOPMENT 13 144 9.011e-05 0.003225
131 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 17 229 9.526e-05 0.003333
132 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 19 9.485e-05 0.003333
133 POST EMBRYONIC DEVELOPMENT 10 89 9.508e-05 0.003333
134 SMOOTH MUSCLE CELL DIFFERENTIATION 6 30 9.828e-05 0.003413
135 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 58 1360 0.0001014 0.003494
136 DIGESTIVE SYSTEM DEVELOPMENT 13 148 0.0001191 0.004016
137 MUSCLE CONTRACTION 17 233 0.0001176 0.004016
138 SKIN DEVELOPMENT 16 211 0.0001186 0.004016
139 PROSTATE GLANDULAR ACINUS DEVELOPMENT 4 11 0.0001232 0.004126
140 SKELETAL SYSTEM DEVELOPMENT 26 455 0.0001358 0.004515
141 SMOOTH MUSCLE CONTRACTION 7 45 0.0001384 0.004566
142 REGULATION OF ION TRANSPORT 31 592 0.0001564 0.005125
143 REGULATION OF SYNAPSE ORGANIZATION 11 113 0.0001591 0.005177
144 NEGATIVE REGULATION OF LOCOMOTION 18 263 0.0001678 0.005421
145 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 13 154 0.0001775 0.005696
146 POSITIVE REGULATION OF RESPONSE TO STIMULUS 75 1929 0.0001834 0.005846
147 REGULATION OF SYNAPSE ASSEMBLY 9 79 0.0001901 0.006018
148 RESPONSE TO FIBROBLAST GROWTH FACTOR 11 116 0.0002008 0.006313
149 EPITHELIAL CELL DIFFERENTIATION 27 495 0.0002161 0.006747
150 SKELETAL SYSTEM MORPHOGENESIS 15 201 0.0002285 0.007089
151 REGULATION OF MEMBRANE POTENTIAL 21 343 0.0002347 0.007183
152 MESODERM DEVELOPMENT 11 118 0.0002334 0.007183
153 POSITIVE REGULATION OF LOCOMOTION 24 420 0.0002434 0.007404
154 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 5 23 0.0002521 0.007569
155 NEGATIVE REGULATION OF CELL COMMUNICATION 51 1192 0.0002509 0.007569
156 CYTOKINE PRODUCTION 11 120 0.0002705 0.008068
157 SECRETION 30 588 0.0003094 0.009111
158 NEURAL CREST CELL MIGRATION 7 51 0.0003091 0.009111
159 EPIDERMIS DEVELOPMENT 17 253 0.0003131 0.009162
160 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 40 876 0.0003333 0.009693
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 43 629 6.122e-09 5.687e-06
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 26 315 1.923e-07 8.933e-05
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 60 1199 5.798e-07 0.0001795
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 25 328 1.443e-06 0.0003351
5 REGULATORY REGION NUCLEIC ACID BINDING 44 818 3.365e-06 0.0005211
6 SEQUENCE SPECIFIC DNA BINDING 52 1037 3.283e-06 0.0005211
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 19 226 6.539e-06 0.0008678
8 ZINC ION BINDING 54 1155 1.575e-05 0.001829
9 DOUBLE STRANDED DNA BINDING 40 764 1.775e-05 0.001832
10 RECEPTOR BINDING 62 1476 8.846e-05 0.008218
11 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 14 168 0.0001161 0.00978
12 STEROID HORMONE RECEPTOR ACTIVITY 8 59 0.0001263 0.00978
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 55 1151 7.001e-06 0.004088
2 SYNAPSE 39 754 2.962e-05 0.008648

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Calcium_signaling_pathway_hsa04020 15 182 7.586e-05 0.003945
2 Regulation_of_actin_cytoskeleton_hsa04810 14 208 0.001017 0.02644
3 MAPK_signaling_pathway_hsa04010 17 295 0.001727 0.02796
4 Hippo_signaling_pathway_hsa04390 11 154 0.002151 0.02796
5 Ras_signaling_pathway_hsa04014 14 232 0.002822 0.02896
6 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.003342 0.02896
7 Wnt_signaling_pathway_hsa04310 10 146 0.004536 0.0337
8 Apelin_signaling_pathway_hsa04371 9 137 0.009001 0.05851
9 Neuroactive_ligand_receptor_interaction_hsa04080 14 278 0.01319 0.07115
10 cAMP_signaling_pathway_hsa04024 11 198 0.01368 0.07115
11 ABC_transporters_hsa02010 4 45 0.02802 0.1324
12 Hedgehog_signaling_pathway_hsa04340 4 47 0.03223 0.1337
13 Focal_adhesion_hsa04510 10 199 0.03343 0.1337
14 Adherens_junction_hsa04520 5 72 0.03773 0.1368
15 PI3K_Akt_signaling_pathway_hsa04151 15 352 0.03945 0.1368
16 Gap_junction_hsa04540 5 88 0.07631 0.2216
17 Ferroptosis_hsa04216 3 40 0.08292 0.2216
18 Phospholipase_D_signaling_pathway_hsa04072 7 146 0.08307 0.2216
19 Sphingolipid_signaling_pathway_hsa04071 6 118 0.08399 0.2216
20 Rap1_signaling_pathway_hsa04015 9 206 0.08522 0.2216
21 Cellular_senescence_hsa04218 7 160 0.1191 0.2949
22 FoxO_signaling_pathway_hsa04068 6 132 0.1252 0.2958
23 Peroxisome_hsa04146 4 83 0.1651 0.3549
24 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.1704 0.3549
25 Cell_adhesion_molecules_.CAMs._hsa04514 6 145 0.1706 0.3549
26 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.2281 0.434
27 Autophagy_animal_hsa04140 5 128 0.2334 0.434
28 Mitophagy_animal_hsa04137 3 65 0.2337 0.434
29 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.2504 0.4437
30 HIF_1_signaling_pathway_hsa04066 4 100 0.256 0.4437
31 Tight_junction_hsa04530 6 170 0.273 0.4579
32 ECM_receptor_interaction_hsa04512 3 82 0.3528 0.5611
33 TGF_beta_signaling_pathway_hsa04350 3 84 0.3668 0.5611
34 ErbB_signaling_pathway_hsa04012 3 85 0.3739 0.5611
35 AMPK_signaling_pathway_hsa04152 4 121 0.3777 0.5611
36 Oocyte_meiosis_hsa04114 4 124 0.3952 0.5708
37 VEGF_signaling_pathway_hsa04370 2 59 0.4501 0.6326
38 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.4809 0.6581
39 p53_signaling_pathway_hsa04115 2 68 0.5247 0.6975
40 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.5439 0.6975
41 Phagosome_hsa04145 4 152 0.5511 0.6975
42 Jak_STAT_signaling_pathway_hsa04630 4 162 0.6015 0.7024
43 Necroptosis_hsa04217 4 164 0.6112 0.7024
44 Cell_cycle_hsa04110 3 124 0.6213 0.7024
45 Endocytosis_hsa04144 5 244 0.7548 0.8177
46 Apoptosis_hsa04210 2 138 0.8732 0.9267
47 mTOR_signaling_pathway_hsa04150 2 151 0.9031 0.9392

Quest ID: 193d9f4e0a3ace8764369d4efa708e70