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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-150-5p VEGFA -1.15 0 0.03 0.81383 miRNAWalker2 validate; miRTarBase -0.11 0 NA
2 hsa-miR-29b-2-5p VEGFA -0.22 0.08431 0.03 0.81383 MirTarget -0.13 0.00172 NA
3 hsa-miR-29b-3p VEGFA -0.35 0.01214 0.03 0.81383 miRNAWalker2 validate; miRTarBase; MirTarget -0.13 0.00126 26155940; 22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 BIOLOGICAL ADHESION 32 1032 6.907e-15 3.214e-11
2 IMMUNE SYSTEM PROCESS 43 1984 1.639e-14 3.785e-11
3 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 29 867 2.441e-14 3.785e-11
4 REGULATION OF CELL ADHESION 25 629 4.369e-14 5.083e-11
5 LEUKOCYTE ACTIVATION 21 414 5.594e-14 5.206e-11
6 POSITIVE REGULATION OF RESPONSE TO STIMULUS 41 1929 1.644e-13 1.275e-10
7 LYMPHOCYTE ACTIVATION 19 342 1.979e-13 1.315e-10
8 CELL ACTIVATION 23 568 3.545e-13 2.062e-10
9 REGULATION OF RESPONSE TO STRESS 35 1468 6.728e-13 3.478e-10
10 POSITIVE REGULATION OF CELL ADHESION 19 376 1.064e-12 4.5e-10
11 REGULATION OF IMMUNE SYSTEM PROCESS 34 1403 1.001e-12 4.5e-10
12 REGULATION OF CELL CELL ADHESION 19 380 1.282e-12 4.971e-10
13 SINGLE ORGANISM CELL ADHESION 20 459 3.876e-12 1.202e-09
14 LEUKOCYTE MIGRATION 16 259 3.677e-12 1.202e-09
15 RESPONSE TO OXYGEN CONTAINING COMPOUND 33 1381 3.476e-12 1.202e-09
16 REGULATION OF HOMOTYPIC CELL CELL ADHESION 17 307 4.286e-12 1.246e-09
17 IMMUNE SYSTEM DEVELOPMENT 22 582 4.788e-12 1.31e-09
18 POSITIVE REGULATION OF CELL ACTIVATION 17 311 5.267e-12 1.362e-09
19 REGULATION OF CELL PROLIFERATION 34 1496 6.004e-12 1.47e-09
20 REGULATION OF CELL ACTIVATION 20 484 1.014e-11 2.358e-09
21 LOCOMOTION 29 1114 1.25e-11 2.769e-09
22 REGULATION OF CELL DEATH 33 1472 1.939e-11 4.101e-09
23 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 35 1656 2.072e-11 4.192e-09
24 REGULATION OF CELLULAR COMPONENT MOVEMENT 24 771 2.672e-11 5.181e-09
25 NEGATIVE REGULATION OF CELL DEATH 25 872 5.596e-11 1.041e-08
26 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 876 6.166e-11 1.103e-08
27 POSITIVE REGULATION OF LOCOMOTION 18 420 6.714e-11 1.157e-08
28 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 31 1395 1.16e-10 1.927e-08
29 CELL MOTILITY 24 835 1.373e-10 2.129e-08
30 LOCALIZATION OF CELL 24 835 1.373e-10 2.129e-08
31 LEUKOCYTE DIFFERENTIATION 15 292 2.44e-10 3.663e-08
32 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 29 1275 3.109e-10 4.521e-08
33 RESPONSE TO OXIDATIVE STRESS 16 352 3.569e-10 5.032e-08
34 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 35 1848 4.225e-10 5.783e-08
35 LYMPHOCYTE COSTIMULATION 9 78 9.583e-10 1.239e-07
36 HOMEOSTATIC PROCESS 29 1337 9.365e-10 1.239e-07
37 RESPONSE TO ENDOGENOUS STIMULUS 30 1450 1.37e-09 1.723e-07
38 POSITIVE REGULATION OF CELL CELL ADHESION 13 243 2.528e-09 3.096e-07
39 CELL CELL ADHESION 19 608 3.776e-09 4.505e-07
40 CELL DEVELOPMENT 29 1426 4.079e-09 4.745e-07
41 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 20 689 4.912e-09 5.575e-07
42 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 23 926 5.783e-09 6.407e-07
43 CARDIOVASCULAR SYSTEM DEVELOPMENT 21 788 8.676e-09 9.175e-07
44 CIRCULATORY SYSTEM DEVELOPMENT 21 788 8.676e-09 9.175e-07
45 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 31 1672 9.347e-09 9.665e-07
46 RESPONSE TO EXTERNAL STIMULUS 32 1821 1.824e-08 1.845e-06
47 RESPONSE TO REACTIVE OXYGEN SPECIES 11 191 2.121e-08 2.099e-06
48 IMMUNE RESPONSE 24 1100 3.114e-08 3.018e-06
49 CIRCULATORY SYSTEM PROCESS 14 366 4.275e-08 4.06e-06
50 LEUKOCYTE CELL CELL ADHESION 12 255 4.444e-08 4.135e-06
51 CELL CHEMOTAXIS 10 162 4.97e-08 4.534e-06
52 CELLULAR CHEMICAL HOMEOSTASIS 17 570 5.337e-08 4.7e-06
53 LYMPHOCYTE DIFFERENTIATION 11 209 5.354e-08 4.7e-06
54 PHOSPHORYLATION 25 1228 5.892e-08 5.077e-06
55 REGULATION OF BODY FLUID LEVELS 16 506 6.141e-08 5.195e-06
56 TISSUE DEVELOPMENT 28 1518 6.52e-08 5.418e-06
57 RESPONSE TO LIPID 21 888 6.747e-08 5.508e-06
58 REGULATION OF CELL GROWTH 14 391 9.671e-08 7.759e-06
59 CELLULAR HOMEOSTASIS 18 676 1.15e-07 9.068e-06
60 REGULATION OF DEFENSE RESPONSE 19 759 1.286e-07 9.977e-06
61 REGULATION OF ANATOMICAL STRUCTURE SIZE 15 472 1.54e-07 1.175e-05
62 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 22 1021 1.594e-07 1.178e-05
63 REGULATION OF CELLULAR RESPONSE TO STRESS 18 691 1.593e-07 1.178e-05
64 PEPTIDYL TYROSINE MODIFICATION 10 186 1.821e-07 1.324e-05
65 EPITHELIUM DEVELOPMENT 21 945 1.912e-07 1.369e-05
66 CHEMICAL HOMEOSTASIS 20 874 2.447e-07 1.725e-05
67 REGULATION OF SEQUESTERING OF CALCIUM ION 8 107 2.636e-07 1.818e-05
68 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 23 1142 2.657e-07 1.818e-05
69 EPITHELIAL CELL DIFFERENTIATION 15 495 2.832e-07 1.91e-05
70 POSITIVE REGULATION OF LEUKOCYTE MIGRATION 8 109 3.042e-07 2.022e-05
71 POSITIVE REGULATION OF CELL PROLIFERATION 19 814 3.762e-07 2.398e-05
72 REGULATION OF ION HOMEOSTASIS 10 201 3.737e-07 2.398e-05
73 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 21 983 3.664e-07 2.398e-05
74 IMMUNOLOGICAL SYNAPSE FORMATION 4 11 3.937e-07 2.476e-05
75 INTRACELLULAR SIGNAL TRANSDUCTION 27 1572 4.919e-07 3.012e-05
76 REGULATION OF HOMEOSTATIC PROCESS 14 447 4.904e-07 3.012e-05
77 LEUKOCYTE CHEMOTAXIS 8 117 5.248e-07 3.171e-05
78 REGENERATION 9 161 5.533e-07 3.301e-05
79 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 7 81 5.652e-07 3.315e-05
80 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 12 323 5.699e-07 3.315e-05
81 HEART MORPHOGENESIS 10 212 6.097e-07 3.484e-05
82 VASCULAR PROCESS IN CIRCULATORY SYSTEM 9 163 6.139e-07 3.484e-05
83 REGULATION OF PROTEIN KINASE B SIGNALING 8 121 6.787e-07 3.805e-05
84 TAXIS 14 464 7.652e-07 4.239e-05
85 REGULATION OF IMMUNE RESPONSE 19 858 8.32e-07 4.399e-05
86 NEGATIVE REGULATION OF HOMEOSTATIC PROCESS 8 124 8.182e-07 4.399e-05
87 PROTEIN PHOSPHORYLATION 20 944 8.227e-07 4.399e-05
88 HEART DEVELOPMENT 14 466 8.053e-07 4.399e-05
89 POSITIVE REGULATION OF CELL COMMUNICATION 26 1532 1.054e-06 5.508e-05
90 DIVALENT INORGANIC CATION HOMEOSTASIS 12 343 1.073e-06 5.548e-05
91 RESPONSE TO INORGANIC SUBSTANCE 14 479 1.115e-06 5.702e-05
92 REGULATION OF EPITHELIAL CELL PROLIFERATION 11 285 1.191e-06 6.025e-05
93 REGULATION OF GROWTH 16 633 1.232e-06 6.162e-05
94 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 5 32 1.265e-06 6.261e-05
95 RESPONSE TO WOUNDING 15 563 1.427e-06 6.697e-05
96 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 8 133 1.392e-06 6.697e-05
97 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 10 233 1.439e-06 6.697e-05
98 VASCULOGENESIS 6 59 1.43e-06 6.697e-05
99 POSITIVE REGULATION OF IMMUNE RESPONSE 15 563 1.427e-06 6.697e-05
100 REGULATION OF VASCULATURE DEVELOPMENT 10 233 1.439e-06 6.697e-05
101 RESPONSE TO HORMONE 19 893 1.507e-06 6.944e-05
102 POSITIVE REGULATION OF T CELL PROLIFERATION 7 95 1.676e-06 7.646e-05
103 REGULATION OF ERK1 AND ERK2 CASCADE 10 238 1.743e-06 7.874e-05
104 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 14 498 1.761e-06 7.877e-05
105 ION HOMEOSTASIS 15 576 1.891e-06 8.379e-05
106 BLOOD VESSEL MORPHOGENESIS 12 364 1.993e-06 8.747e-05
107 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 2.068e-06 8.991e-05
108 REGULATION OF MAPK CASCADE 16 660 2.116e-06 9.118e-05
109 MYELOID LEUKOCYTE MIGRATION 7 99 2.214e-06 9.451e-05
110 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 25 1492 2.235e-06 9.452e-05
111 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 513 2.488e-06 0.0001039
112 REGULATION OF PROTEIN MODIFICATION PROCESS 27 1710 2.501e-06 0.0001039
113 ORGAN MORPHOGENESIS 18 841 2.704e-06 0.0001113
114 REGULATION OF ACTIN FILAMENT BASED PROCESS 11 312 2.864e-06 0.0001169
115 REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 1618 2.908e-06 0.0001177
116 REGULATION OF LEUKOCYTE MIGRATION 8 149 3.266e-06 0.000131
117 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 20 1036 3.416e-06 0.0001347
118 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1036 3.416e-06 0.0001347
119 REGULATION OF HYDROLASE ACTIVITY 23 1327 3.51e-06 0.0001364
120 CELLULAR RESPONSE TO CYTOKINE STIMULUS 15 606 3.517e-06 0.0001364
121 NEGATIVE REGULATION OF TRANSPORT 13 458 3.805e-06 0.0001463
122 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 5 40 3.978e-06 0.0001505
123 POSITIVE REGULATION OF CELL MATRIX ADHESION 5 40 3.978e-06 0.0001505
124 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 29 1977 4.218e-06 0.0001583
125 VASCULATURE DEVELOPMENT 13 469 4.922e-06 0.0001832
126 POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 5 42 5.093e-06 0.0001881
127 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 23 1360 5.277e-06 0.0001934
128 NEGATIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 5 43 5.736e-06 0.0002085
129 RUFFLE ORGANIZATION 4 21 6.817e-06 0.0002459
130 DETOXIFICATION 6 77 6.891e-06 0.0002466
131 REGULATION OF CELL DIFFERENTIATION 24 1492 7.447e-06 0.0002645
132 POSITIVE REGULATION OF CHEMOTAXIS 7 120 7.975e-06 0.0002811
133 CALCIUM ION TRANSPORT 9 223 8.118e-06 0.000284
134 REGULATION OF CELLULAR EXTRAVASATION 4 22 8.293e-06 0.000288
135 POSITIVE REGULATION OF CELL DIFFERENTIATION 17 823 8.409e-06 0.0002898
136 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 19 1008 8.703e-06 0.0002977
137 NEGATIVE REGULATION OF NEURON DEATH 8 171 9.032e-06 0.0003068
138 POSITIVE REGULATION OF LEUKOCYTE CHEMOTAXIS 6 81 9.25e-06 0.0003119
139 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 8 172 9.426e-06 0.0003155
140 REGULATION OF LIPID KINASE ACTIVITY 5 48 9.962e-06 0.0003311
141 ACTIVATION OF IMMUNE RESPONSE 12 427 1.013e-05 0.0003344
142 ORGAN REGENERATION 6 83 1.065e-05 0.000348
143 HOMEOSTASIS OF NUMBER OF CELLS 8 175 1.069e-05 0.000348
144 RESPONSE TO ABIOTIC STIMULUS 19 1024 1.087e-05 0.0003512
145 LYMPHOCYTE MIGRATION 5 49 1.104e-05 0.0003519
146 ANGIOGENESIS 10 293 1.097e-05 0.0003519
147 PEPTIDYL AMINO ACID MODIFICATION 17 841 1.114e-05 0.0003527
148 RESPONSE TO ALCOHOL 11 362 1.172e-05 0.0003684
149 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 10 296 1.198e-05 0.0003743
150 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 8 179 1.261e-05 0.0003911
151 DEFENSE RESPONSE 21 1231 1.271e-05 0.0003916
152 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 20 1135 1.319e-05 0.0004038
153 RESPONSE TO TOXIC SUBSTANCE 9 241 1.511e-05 0.0004564
154 EXTRACELLULAR STRUCTURE ORGANIZATION 10 304 1.509e-05 0.0004564
155 EPITHELIAL CELL DEVELOPMENT 8 186 1.665e-05 0.0004998
156 ENDOTHELIUM DEVELOPMENT 6 90 1.698e-05 0.0005066
157 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 7 135 1.723e-05 0.0005108
158 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 7 136 1.808e-05 0.0005325
159 RESPONSE TO OXYGEN LEVELS 10 311 1.836e-05 0.0005373
160 TISSUE MORPHOGENESIS 13 533 1.921e-05 0.0005584
161 POSITIVE REGULATION OF NEUTROPHIL MIGRATION 4 27 1.944e-05 0.0005584
162 PHAGOCYTOSIS 8 190 1.941e-05 0.0005584
163 NATURAL KILLER CELL ACTIVATION 5 55 1.957e-05 0.0005587
164 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 1.988e-05 0.0005639
165 REGULATION OF TRANSPORT 26 1804 2.036e-05 0.0005741
166 REGULATION OF NEURON APOPTOTIC PROCESS 8 192 2.094e-05 0.0005868
167 REGULATION OF NEURON DEATH 9 252 2.151e-05 0.0005958
168 OUTFLOW TRACT MORPHOGENESIS 5 56 2.139e-05 0.0005958
169 REGULATION OF CELLULAR LOCALIZATION 21 1277 2.2e-05 0.0006058
170 RESPONSE TO ACID CHEMICAL 10 319 2.283e-05 0.0006247
171 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 8 195 2.34e-05 0.0006368
172 PLATELET ACTIVATION 7 142 2.391e-05 0.0006468
173 REGULATION OF LEUKOCYTE CHEMOTAXIS 6 96 2.456e-05 0.000658
174 RESPONSE TO CYTOKINE 15 714 2.461e-05 0.000658
175 CELLULAR RESPIRATION 7 143 2.501e-05 0.0006651
176 POSITIVE REGULATION OF MAPK CASCADE 12 470 2.62e-05 0.0006848
177 REGULATION OF DEFENSE RESPONSE TO VIRUS BY VIRUS 4 29 2.607e-05 0.0006848
178 NEGATIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 4 29 2.607e-05 0.0006848
179 REGULATION OF T CELL PROLIFERATION 7 147 2.987e-05 0.0007765
180 NEGATIVE REGULATION OF LOCOMOTION 9 263 3.009e-05 0.0007779
181 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 8 203 3.12e-05 0.0008022
182 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 5 61 3.253e-05 0.0008316
183 REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 6 101 3.277e-05 0.0008332
184 RESPONSE TO ORGANIC CYCLIC COMPOUND 17 917 3.362e-05 0.0008503
185 REGULATION OF CYTOKINE PRODUCTION 13 563 3.394e-05 0.0008536
186 REGULATION OF LEUKOCYTE PROLIFERATION 8 206 3.464e-05 0.0008666
187 DIVALENT INORGANIC CATION TRANSPORT 9 268 3.486e-05 0.0008674
188 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 7 152 3.701e-05 0.0009161
189 REGULATION OF NEUTROPHIL MIGRATION 4 32 3.892e-05 0.0009582
190 REGULATION OF RESPONSE TO WOUNDING 11 413 3.941e-05 0.0009651
191 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 274 4.142e-05 0.001009
192 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 7 156 4.369e-05 0.001059
193 DENDRITIC CELL DIFFERENTIATION 4 33 4.408e-05 0.001063
194 NATURAL KILLER CELL DIFFERENTIATION 3 12 4.455e-05 0.001068
195 POSITIVE REGULATION OF MOLECULAR FUNCTION 25 1791 5.162e-05 0.001232
196 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 5 68 5.512e-05 0.001309
197 INDUCTION OF POSITIVE CHEMOTAXIS 3 13 5.766e-05 0.001355
198 EXTRACELLULAR FIBRIL ORGANIZATION 3 13 5.766e-05 0.001355
199 CELL SUBSTRATE ADHESION 7 164 6.001e-05 0.001403
200 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 36 6.258e-05 0.001442
201 POSITIVE CHEMOTAXIS 4 36 6.258e-05 0.001442
202 HEAD MORPHOGENESIS 4 36 6.258e-05 0.001442
203 POSITIVE REGULATION OF DEFENSE RESPONSE 10 364 6.939e-05 0.001591
204 RESPONSE TO EXTRACELLULAR STIMULUS 11 441 7.107e-05 0.001619
205 REGULATION OF INFLAMMATORY RESPONSE 9 294 7.131e-05 0.001619
206 ENDOTHELIAL CELL DIFFERENTIATION 5 72 7.258e-05 0.001632
207 CHEMOKINE MEDIATED SIGNALING PATHWAY 5 72 7.258e-05 0.001632
208 MAMMARY GLAND DEVELOPMENT 6 117 7.481e-05 0.001673
209 LYMPHOCYTE CHEMOTAXIS 4 38 7.77e-05 0.001722
210 MESENCHYME MORPHOGENESIS 4 38 7.77e-05 0.001722
211 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 5 74 8.277e-05 0.001825
212 CYTOKINE PRODUCTION 6 120 8.61e-05 0.00189
213 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 15 799 8.818e-05 0.001926
214 ENDOCARDIAL CUSHION FORMATION 3 15 9.093e-05 0.001932
215 INNATE IMMUNE RESPONSE 13 619 8.899e-05 0.001932
216 POSITIVE REGULATION OF ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 3 15 9.093e-05 0.001932
217 VENOUS BLOOD VESSEL DEVELOPMENT 3 15 9.093e-05 0.001932
218 MRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 3 15 9.093e-05 0.001932
219 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 9 303 8.976e-05 0.001932
220 POSITIVE REGULATION OF CATALYTIC ACTIVITY 22 1518 9.169e-05 0.001937
221 INFLAMMATORY RESPONSE 11 454 9.198e-05 0.001937
222 OXIDATION REDUCTION PROCESS 16 898 9.312e-05 0.001952
223 GLIAL CELL DEVELOPMENT 5 76 9.403e-05 0.001962
224 CELLULAR COMPONENT MORPHOGENESIS 16 900 9.556e-05 0.001985
225 T CELL DIFFERENTIATION 6 123 9.872e-05 0.002042
226 REGULATION OF CHEMOTAXIS 7 180 0.0001077 0.002217
227 DENDRITIC CELL CHEMOTAXIS 3 16 0.0001114 0.002264
228 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 0.0001114 0.002264
229 POSITIVE REGULATION OF ANTIGEN PROCESSING AND PRESENTATION 3 16 0.0001114 0.002264
230 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 5 79 0.0001131 0.002288
231 CALCIUM ION TRANSMEMBRANE IMPORT INTO CYTOSOL 4 42 0.0001157 0.00232
232 CALCIUM ION IMPORT INTO CYTOSOL 4 42 0.0001157 0.00232
233 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 0.000123 0.002455
234 CELLULAR RESPONSE TO OXIDATIVE STRESS 7 184 0.0001234 0.002455
235 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 4 43 0.0001269 0.002513
236 NEGATIVE REGULATION OF CELL PROLIFERATION 13 643 0.0001299 0.002562
237 NEGATIVE REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 17 0.0001347 0.002645
238 RESPONSE TO GROWTH FACTOR 11 475 0.0001369 0.002676
239 BODY MORPHOGENESIS 4 44 0.000139 0.002695
240 NEGATIVE REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 4 44 0.000139 0.002695
241 CELL MATURATION 6 131 0.0001397 0.002696
242 RESPONSE TO FATTY ACID 5 83 0.0001429 0.002748
243 B CELL ACTIVATION 6 132 0.0001456 0.00278
244 MYELOID CELL DIFFERENTIATION 7 189 0.0001458 0.00278
245 ENDOTHELIAL CELL DEVELOPMENT 4 45 0.0001518 0.002884
246 POSITIVE REGULATION OF KINASE ACTIVITY 11 482 0.0001555 0.002941
247 RESPONSE TO OXYGEN RADICAL 3 18 0.0001609 0.003032
248 DEVELOPMENTAL MATURATION 7 193 0.0001659 0.003112
249 POSITIVE REGULATION OF RECEPTOR MEDIATED ENDOCYTOSIS 4 47 0.0001801 0.003366
250 MYELOID CELL HOMEOSTASIS 5 88 0.0001883 0.003477
251 CELLULAR RESPONSE TO INTERLEUKIN 1 5 88 0.0001883 0.003477
252 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 7 197 0.0001882 0.003477
253 FIBRIL ORGANIZATION 3 19 0.0001903 0.0035
254 REGULATION OF CELL SHAPE 6 139 0.000193 0.003536
255 RESPONSE TO NITROGEN COMPOUND 15 859 0.0001951 0.003555
256 RESPONSE TO AXON INJURY 4 48 0.0001956 0.003555
257 REGULATION OF CELLULAR COMPONENT SIZE 9 337 0.0001997 0.003613
258 CELL PROLIFERATION 13 672 0.0002003 0.003613
259 RESPONSE TO STEROID HORMONE 11 497 0.0002027 0.003638
260 REGULATION OF GTPASE ACTIVITY 13 673 0.0002033 0.003638
261 REGULATION OF CELL MATRIX ADHESION 5 90 0.0002092 0.00373
262 SECRETION 12 588 0.000219 0.00389
263 POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 3 20 0.0002229 0.003943
264 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 6 143 0.0002251 0.003968
265 FACE DEVELOPMENT 4 50 0.0002293 0.004027
266 REGULATION OF KINASE ACTIVITY 14 776 0.0002318 0.004042
267 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 5 92 0.0002319 0.004042
268 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 145 0.0002427 0.004213
269 NEGATIVE REGULATION OF CALCIUM ION TRANSPORT 4 51 0.0002477 0.004285
270 ENDOCYTOSIS 11 509 0.0002488 0.004288
271 RESPONSE TO ESTRADIOL 6 146 0.0002519 0.004308
272 T CELL RECEPTOR SIGNALING PATHWAY 6 146 0.0002519 0.004308
273 DENDRITIC CELL MIGRATION 3 21 0.0002589 0.004397
274 MRNA TRANSCRIPTION 3 21 0.0002589 0.004397
275 NEGATIVE REGULATION OF CELL COMMUNICATION 18 1192 0.0002637 0.004462
276 ORGANOPHOSPHATE METABOLIC PROCESS 15 885 0.0002687 0.004529
277 REGULATION OF CALCIUM ION TRANSPORT 7 209 0.00027 0.004536
278 RESPONSE TO BIOTIC STIMULUS 15 886 0.0002719 0.004551
279 MYELOID LEUKOCYTE DIFFERENTIATION 5 96 0.0002828 0.004683
280 REGULATION OF CYTOKINE SECRETION 6 149 0.000281 0.004683
281 POSITIVE REGULATION OF CYTOKINE SECRETION 5 96 0.0002828 0.004683
282 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 0.0002876 0.004712
283 AEROBIC RESPIRATION 4 53 0.0002876 0.004712
284 CYTOSOLIC CALCIUM ION TRANSPORT 4 53 0.0002876 0.004712
285 REGULATION OF INTERFERON GAMMA PRODUCTION 5 97 0.0002968 0.004845
286 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 0.0002985 0.004851
287 EMBRYO DEVELOPMENT 15 894 0.0002992 0.004851
288 REGULATION OF LIPID METABOLIC PROCESS 8 282 0.0003042 0.004914
289 B CELL RECEPTOR SIGNALING PATHWAY 4 54 0.0003092 0.004978
290 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 14 801 0.0003198 0.005131
291 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 5 99 0.0003262 0.005217
292 CELL PROJECTION ORGANIZATION 15 902 0.0003289 0.005241
293 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 12 616 0.0003342 0.005308
294 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 6 154 0.0003355 0.00531
295 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 7 217 0.000339 0.005319
296 REGULATION OF ANTIGEN PROCESSING AND PRESENTATION 3 23 0.0003417 0.005319
297 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 5 100 0.0003418 0.005319
298 REGULATION OF SUPEROXIDE METABOLIC PROCESS 3 23 0.0003417 0.005319
299 TRABECULA FORMATION 3 23 0.0003417 0.005319
300 REGULATION OF APOPTOTIC SIGNALING PATHWAY 9 363 0.0003451 0.005353
301 RESPONSE TO ESTROGEN 7 218 0.0003485 0.005388
302 NEGATIVE REGULATION OF STEROID METABOLIC PROCESS 3 24 0.0003889 0.005913
303 REGULATION OF POSITIVE CHEMOTAXIS 3 24 0.0003889 0.005913
304 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 3 24 0.0003889 0.005913
305 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 3 24 0.0003889 0.005913
306 REGULATION OF T CELL MIGRATION 3 24 0.0003889 0.005913
307 REGULATION OF CALCIUM ION IMPORT 5 103 0.0003918 0.005938
308 NEGATIVE REGULATION OF CELL ADHESION 7 223 0.0003995 0.006035
309 NEGATIVE REGULATION OF WOUND HEALING 4 58 0.0004072 0.006132
310 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 23 1805 0.0004125 0.006192
311 RESPONSE TO PROSTAGLANDIN E 3 25 0.00044 0.006519
312 CELLULAR EXTRAVASATION 3 25 0.00044 0.006519
313 NEGATIVE REGULATION OF CALCIUM ION IMPORT 3 25 0.00044 0.006519
314 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 6 162 0.0004395 0.006519
315 CELL CELL RECOGNITION 4 60 0.0004637 0.00685
316 POSITIVE REGULATION OF TRANSPORT 15 936 0.0004849 0.00714
317 POSITIVE REGULATION OF LYMPHOCYTE MIGRATION 3 26 0.0004952 0.007178
318 NEGATIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 4 61 0.000494 0.007178
319 VASODILATION 3 26 0.0004952 0.007178
320 GLUTATHIONE METABOLIC PROCESS 4 61 0.000494 0.007178
321 SCHWANN CELL DEVELOPMENT 3 26 0.0004952 0.007178
322 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 0.0004979 0.007194
323 RESPONSE TO HYDROGEN PEROXIDE 5 109 0.0005082 0.00732
324 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 17 1152 0.0005159 0.007409
325 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 62 0.0005256 0.007525
326 REGULATION OF TRANSFERASE ACTIVITY 15 946 0.0005414 0.007681
327 WOUND HEALING 10 470 0.0005409 0.007681
328 REGULATION OF CELL PROJECTION ORGANIZATION 11 558 0.00054 0.007681
329 REGULATION OF BLOOD PRESSURE 6 169 0.0005497 0.007774
330 REGULATION OF RYANODINE SENSITIVE CALCIUM RELEASE CHANNEL ACTIVITY 3 27 0.0005546 0.007797
331 REGULATION OF NEUTROPHIL CHEMOTAXIS 3 27 0.0005546 0.007797
332 NEGATIVE REGULATION OF GROWTH 7 236 0.0005601 0.00785
333 NEGATIVE REGULATION OF CELL GROWTH 6 170 0.0005671 0.0079
334 REGULATION OF PROTEIN LOCALIZATION 15 950 0.0005656 0.0079
335 REGULATION OF PROTEIN SECRETION 9 389 0.0005689 0.007902
336 HEMOSTASIS 8 311 0.000582 0.00806
337 TISSUE HOMEOSTASIS 6 171 0.0005848 0.008075
338 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 15 957 0.0006101 0.008398
339 REGULATION OF CELL SUBSTRATE ADHESION 6 173 0.0006217 0.008533
340 POSITIVE REGULATION OF ENDOCYTOSIS 5 114 0.0006235 0.008533
341 CALCIUM ION IMPORT 4 65 0.0006292 0.008585
342 INTERSPECIES INTERACTION BETWEEN ORGANISMS 12 662 0.0006343 0.008604
343 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 12 662 0.0006343 0.008604
344 RESPONSE TO INTERLEUKIN 1 5 115 0.0006488 0.008776
345 REGULATION OF ORGANELLE ORGANIZATION 17 1178 0.0006634 0.008947
346 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 5 116 0.0006748 0.009075
347 REGULATION OF CGMP METABOLIC PROCESS 3 29 0.0006868 0.009186
348 REGULATION OF MAP KINASE ACTIVITY 8 319 0.000687 0.009186
349 MORPHOGENESIS OF AN EPITHELIUM 9 400 0.000694 0.009253
350 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 5 117 0.0007016 0.009301
351 IMMUNE EFFECTOR PROCESS 10 486 0.0007001 0.009301
352 CELL AGING 4 67 0.0007058 0.009329
353 NEGATIVE REGULATION OF MOLECULAR FUNCTION 16 1079 0.0007241 0.009545
354 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN 4 68 0.0007464 0.009783
355 TUBE MORPHOGENESIS 8 323 0.000745 0.009783
356 HYDROGEN PEROXIDE METABOLIC PROCESS 3 30 0.0007598 0.009903
357 REGULATION OF VASCULAR PERMEABILITY 3 30 0.0007598 0.009903
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN TYROSINE KINASE ACTIVITY 10 176 1.086e-07 0.0001009
2 IDENTICAL PROTEIN BINDING 23 1209 7.202e-07 0.000223
3 RECEPTOR BINDING 26 1476 5.199e-07 0.000223
4 PROTEIN DIMERIZATION ACTIVITY 21 1149 4.425e-06 0.0008222
5 ANTIOXIDANT ACTIVITY 6 70 3.943e-06 0.0008222
6 PROTEIN KINASE ACTIVITY 15 640 6.79e-06 0.001051
7 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 6 81 9.25e-06 0.001228
8 KINASE ACTIVITY 17 842 1.132e-05 0.001314
9 PROTEIN HOMODIMERIZATION ACTIVITY 15 722 2.798e-05 0.002889
10 GLYCOPROTEIN BINDING 6 101 3.277e-05 0.003044
11 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 5 64 4.109e-05 0.00332
12 PROTEIN COMPLEX BINDING 17 935 4.289e-05 0.00332
13 SIGNAL TRANSDUCER ACTIVITY 24 1731 8.354e-05 0.005506
14 MACROMOLECULAR COMPLEX BINDING 21 1399 8.28e-05 0.005506
15 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 17 992 8.89e-05 0.005506
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 24 1376 1.852e-06 0.001081
2 EXTRACELLULAR MATRIX 12 426 9.899e-06 0.001597
3 CELL SURFACE 16 757 1.197e-05 0.001597
4 SIDE OF MEMBRANE 12 428 1.037e-05 0.001597
5 EXTERNAL SIDE OF PLASMA MEMBRANE 9 238 1.367e-05 0.001597
6 LAMELLIPODIUM 7 172 8.101e-05 0.007885

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 1.727e-08 8.978e-07
2 Focal_adhesion_hsa04510 9 199 3.22e-06 8.371e-05
3 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 3.694e-05 0.0006403
4 Ras_signaling_pathway_hsa04014 8 232 8.003e-05 0.00104
5 Rap1_signaling_pathway_hsa04015 7 206 0.0002473 0.002335
6 NF_kappa_B_signaling_pathway_hsa04064 5 95 0.0002694 0.002335
7 cAMP_signaling_pathway_hsa04024 6 198 0.001252 0.008407
8 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.001293 0.008407
9 MAPK_signaling_pathway_hsa04010 7 295 0.002037 0.01177
10 HIF_1_signaling_pathway_hsa04066 4 100 0.003103 0.01613
11 VEGF_signaling_pathway_hsa04370 3 59 0.005363 0.02535
12 Adherens_junction_hsa04520 3 72 0.009301 0.03755
13 Apelin_signaling_pathway_hsa04371 4 137 0.009386 0.03755
14 ErbB_signaling_pathway_hsa04012 3 85 0.01456 0.05409
15 Tight_junction_hsa04530 4 170 0.01933 0.06701
16 Ferroptosis_hsa04216 2 40 0.024 0.07375
17 Calcium_signaling_pathway_hsa04020 4 182 0.02411 0.07375
18 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.02622 0.07574
19 Sphingolipid_signaling_pathway_hsa04071 3 118 0.03417 0.09352
20 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.03675 0.09554
21 Apoptosis_hsa04210 3 138 0.0504 0.1248
22 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.05776 0.1306
23 Wnt_signaling_pathway_hsa04310 3 146 0.05776 0.1306
24 Jak_STAT_signaling_pathway_hsa04630 3 162 0.07392 0.1602
25 Peroxisome_hsa04146 2 83 0.08882 0.1813
26 TGF_beta_signaling_pathway_hsa04350 2 84 0.09064 0.1813
27 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.1192 0.2296
28 Autophagy_animal_hsa04140 2 128 0.1792 0.3329
29 FoxO_signaling_pathway_hsa04068 2 132 0.1879 0.3368
30 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.2031 0.352
31 mTOR_signaling_pathway_hsa04150 2 151 0.2295 0.372
32 Phagosome_hsa04145 2 152 0.2317 0.372
33 Hippo_signaling_pathway_hsa04390 2 154 0.2361 0.372
34 Cellular_senescence_hsa04218 2 160 0.2494 0.3805
35 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.2561 0.3805

Quest ID: 386195724affefc9a4d348018bb85188