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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-708-5p ADAMTS15 3.38 0 -2.81 0 mirMAP -0.18 0.01073 NA
2 hsa-miR-708-5p ADCY9 3.38 0 -1.5 0 mirMAP -0.11 0.00061 NA
3 hsa-miR-708-5p AMOTL2 3.38 0 -1.01 0.00015 miRNATAP -0.14 1.0E-5 NA
4 hsa-miR-708-5p ASPA 3.38 0 -4.76 0 MirTarget -0.41 0 NA
5 hsa-miR-708-5p ATRNL1 3.38 0 -2.48 0 MirTarget -0.25 7.0E-5 NA
6 hsa-miR-708-5p CAMK1D 3.38 0 -0.52 0.15669 mirMAP -0.12 0.00654 NA
7 hsa-miR-708-5p CAPN6 3.38 0 -3.48 0 miRNATAP -0.23 0.00671 NA
8 hsa-miR-708-5p CBX6 3.38 0 -1.54 0 mirMAP -0.14 8.0E-5 NA
9 hsa-miR-708-5p CCDC141 3.38 0 -2.94 0 mirMAP -0.18 0.00044 NA
10 hsa-miR-708-5p CCND2 3.38 0 -2.43 0 mirMAP -0.19 3.0E-5 NA
11 hsa-miR-708-5p CNTN2 3.38 0 -3.83 0 mirMAP -0.15 0.01792 NA
12 hsa-miR-708-5p DPF3 3.38 0 -1.67 1.0E-5 mirMAP -0.17 9.0E-5 NA
13 hsa-miR-708-5p DUSP3 3.38 0 -1.04 0 mirMAP -0.12 0 NA
14 hsa-miR-708-5p FAIM2 3.38 0 -5.19 0 MirTarget -0.2 0.00525 NA
15 hsa-miR-708-5p FAM107A 3.38 0 -5.01 0 MirTarget -0.3 0 NA
16 hsa-miR-708-5p FOXN3 3.38 0 -1.44 0 MirTarget; miRNATAP -0.11 0 NA
17 hsa-miR-708-5p FREM1 3.38 0 -3.1 0 MirTarget -0.29 6.0E-5 NA
18 hsa-miR-708-5p FZD4 3.38 0 -0.83 0.00068 miRNATAP -0.13 1.0E-5 NA
19 hsa-miR-708-5p GNAO1 3.38 0 -3.6 0 mirMAP -0.25 1.0E-5 NA
20 hsa-miR-708-5p GPM6A 3.38 0 -4.43 0 miRNATAP -0.29 4.0E-5 NA
21 hsa-miR-708-5p GSTT2 3.38 0 -0.45 0.25676 MirTarget -0.11 0.01912 NA
22 hsa-miR-708-5p KIF13B 3.38 0 -1.04 0 mirMAP -0.12 0 NA
23 hsa-miR-708-5p MAP1B 3.38 0 -3.18 0 MirTarget -0.19 9.0E-5 NA
24 hsa-miR-708-5p MASP1 3.38 0 -4.43 0 MirTarget -0.32 0 NA
25 hsa-miR-708-5p NDRG2 3.38 0 -0.79 0.03431 miRNATAP -0.1 0.02339 NA
26 hsa-miR-708-5p NFIC 3.38 0 -1.57 0 mirMAP -0.16 0 NA
27 hsa-miR-708-5p NNAT 3.38 0 -2.92 0 MirTarget; miRNATAP -0.33 1.0E-5 26075749 Metformin promotes increased expression of miR-708-5p leading to suppression of endoplasmic reticulum ER membrane protein neuronatin NNAT expression and subsequently induces apoptosis of prostate cancer cells through the ER stress pathway; This novel regulatory mechanism of metformin in prostate cancer cells not only advances our knowledge on the molecular mechanism of metformin but also provides a promising therapeutic strategy by targeting miR-708-5p and NNAT for prostate cancer treatment
28 hsa-miR-708-5p NPTXR 3.38 0 -1.27 0.01306 mirMAP -0.14 0.02118 NA
29 hsa-miR-708-5p NTRK3 3.38 0 -5.17 0 mirMAP -0.26 0.00011 NA
30 hsa-miR-708-5p PDZD4 3.38 0 -3.5 0 miRNATAP -0.15 0.0042 NA
31 hsa-miR-708-5p PITPNM3 3.38 0 -1.79 3.0E-5 MirTarget -0.1 0.04769 NA
32 hsa-miR-708-5p PPP1R12B 3.38 0 -3.46 0 mirMAP -0.31 0 NA
33 hsa-miR-708-5p PTGS1 3.38 0 -4.36 0 miRNAWalker2 validate -0.28 4.0E-5 NA
34 hsa-miR-708-5p PTGS2 3.38 0 -2.9 0 MirTarget -0.22 0.00038 NA
35 hsa-miR-708-5p PXK 3.38 0 -1.05 2.0E-5 MirTarget -0.13 1.0E-5 NA
36 hsa-miR-708-5p RASSF2 3.38 0 -1.41 3.0E-5 MirTarget -0.15 0.00018 NA
37 hsa-miR-708-5p RGL1 3.38 0 -1.52 0 MirTarget -0.13 3.0E-5 NA
38 hsa-miR-708-5p RHOBTB2 3.38 0 -0.43 0.15473 mirMAP -0.12 0.00066 NA
39 hsa-miR-708-5p SARM1 3.38 0 -0.74 0.01577 MirTarget -0.14 0.00019 NA
40 hsa-miR-708-5p SCUBE1 3.38 0 -2.96 0 MirTarget -0.23 2.0E-5 NA
41 hsa-miR-708-5p STARD8 3.38 0 -1.76 0 MirTarget -0.11 0.00063 NA
42 hsa-miR-708-5p SYNPO 3.38 0 -1.74 0 miRNATAP -0.13 2.0E-5 NA
43 hsa-miR-708-5p TMEM88 3.38 0 -1.72 0 miRNAWalker2 validate; miRTarBase -0.12 0.00037 22573352 The transcript for TMEM88 gene has a miR-708 binding site in its 3' UTR and was significantly reduced in tumors high of miR-708; Forced miR-708 expression reduced TMEM88 transcript levels and increased the rate of cell proliferation invasion and migration in culture
44 hsa-miR-708-5p TNS1 3.38 0 -3.79 0 mirMAP -0.31 0 NA
45 hsa-miR-708-5p WNK3 3.38 0 -1.25 0.00862 MirTarget -0.19 0.00072 NA
46 hsa-miR-708-5p WNT9A 3.38 0 -2.07 0 mirMAP -0.18 0.00053 NA
47 hsa-miR-708-5p ZC3H12B 3.38 0 -1.8 0 miRNATAP -0.11 0.00932 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 13 1265 4.533e-06 0.002551
2 NEURON PROJECTION 11 942 8.736e-06 0.002551

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Wnt_signaling_pathway_hsa04310 3 146 0.004886 0.1473
2 Hippo_signaling_pathway_hsa04390 3 154 0.005665 0.1473
3 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.0423 0.5488
4 mTOR_signaling_pathway_hsa04150 2 151 0.04907 0.5488
5 Tight_junction_hsa04530 2 170 0.06054 0.5488
6 Focal_adhesion_hsa04510 2 199 0.07958 0.5488
7 Rap1_signaling_pathway_hsa04015 2 206 0.08443 0.5488

Quest ID: 440ab3dd5458631d63a4079820a147ee