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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-375 ABCA8 -3.08 0 0.44 0.01932 miRanda -0.25 0 NA
2 hsa-miR-375 ABCD3 -3.08 0 0.51 0 miRanda -0.1 0 NA
3 hsa-miR-375 ABHD4 -3.08 0 0.47 0 miRNAWalker2 validate -0.14 0 NA
4 hsa-miR-375 ABHD6 -3.08 0 0.96 0 miRanda -0.26 0 NA
5 hsa-miR-375 ACSL4 -3.08 0 1.19 0 miRNAWalker2 validate; miRanda -0.34 0 NA
6 hsa-miR-375 ACSL5 -3.08 0 0.07 0.72152 miRNATAP -0.19 0 NA
7 hsa-miR-375 ADAM22 -3.08 0 1.06 1.0E-5 miRanda -0.39 0 NA
8 hsa-miR-375 ADCY3 -3.08 0 0.59 0 miRanda -0.23 0 NA
9 hsa-miR-375 AGPS -3.08 0 0.88 0 miRNATAP -0.24 0 NA
10 hsa-miR-375 AHDC1 -3.08 0 0.63 0 miRanda -0.21 0 NA
11 hsa-miR-375 AHR -3.08 0 1.07 0 miRanda; miRNATAP -0.37 0 NA
12 hsa-miR-375 AKAP6 -3.08 0 0.91 0 miRanda -0.26 0 NA
13 hsa-miR-375 ANKMY2 -3.08 0 0.62 0 miRNATAP -0.15 0 NA
14 hsa-miR-375 ANKRD1 -3.08 0 0.55 0.18775 miRNAWalker2 validate -0.3 0.00079 NA
15 hsa-miR-375 ANKRD44 -3.08 0 0.89 0 miRanda -0.31 0 NA
16 hsa-miR-375 ANO4 -3.08 0 1.68 0 miRanda -0.41 0 NA
17 hsa-miR-375 APBB1IP -3.08 0 0.14 0.33276 miRanda; miRNATAP -0.19 0 NA
18 hsa-miR-375 APLF -3.08 0 0.91 0 miRanda -0.29 0 NA
19 hsa-miR-375 APOB -3.08 0 1.73 0 miRanda -0.56 0 NA
20 hsa-miR-375 AQP4 -3.08 0 1.1 0 miRanda -0.19 1.0E-5 NA
21 hsa-miR-375 ARL4C -3.08 0 0.78 0 MirTarget; miRNATAP -0.24 0 NA
22 hsa-miR-375 ARNTL2 -3.08 0 0.75 0.0008 miRNAWalker2 validate -0.31 0 NA
23 hsa-miR-375 AS3MT -3.08 0 0.71 0 miRanda -0.12 6.0E-5 NA
24 hsa-miR-375 ATF7IP -3.08 0 0.55 0 miRanda -0.15 0 NA
25 hsa-miR-375 ATP1B1 -3.08 0 1.17 0 miRanda; miRNATAP -0.35 0 NA
26 hsa-miR-375 AVPR1A -3.08 0 1.04 4.0E-5 miRanda -0.39 0 NA
27 hsa-miR-375 AXL -3.08 0 0.75 0 miRNAWalker2 validate -0.31 0 NA
28 hsa-miR-375 BACH2 -3.08 0 0.74 0 miRNATAP -0.29 0 NA
29 hsa-miR-375 BAG4 -3.08 0 0.8 0 miRanda -0.2 0 NA
30 hsa-miR-375 BATF2 -3.08 0 0.88 0 miRNAWalker2 validate -0.36 0 NA
31 hsa-miR-375 BCL11B -3.08 0 0.6 0.00098 miRanda -0.3 0 NA
32 hsa-miR-375 BCL2 -3.08 0 1.2 0 miRNAWalker2 validate -0.38 0 26381132; 26697569; 25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated
33 hsa-miR-375 BCL6 -3.08 0 0.36 0.00062 miRanda -0.12 0 NA
34 hsa-miR-375 BCO2 -3.08 0 0.45 0.00248 miRanda -0.13 3.0E-5 NA
35 hsa-miR-375 BDH2 -3.08 0 1.01 0 miRNAWalker2 validate -0.31 0 NA
36 hsa-miR-375 BEND6 -3.08 0 0.83 0 miRanda -0.25 0 NA
37 hsa-miR-375 BIN2 -3.08 0 -0.02 0.90479 miRNATAP -0.14 1.0E-5 NA
38 hsa-miR-375 BIRC3 -3.08 0 0.33 0.02185 miRNAWalker2 validate -0.23 0 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization
39 hsa-miR-375 BNC2 -3.08 0 1.29 0 miRNATAP -0.45 0 NA
40 hsa-miR-375 BVES -3.08 0 1.18 0 miRNATAP -0.33 0 NA
41 hsa-miR-375 C15orf41 -3.08 0 1.35 0 miRNATAP -0.36 0 NA
42 hsa-miR-375 C7 -3.08 0 1.1 0 miRanda; miRNATAP -0.42 0 NA
43 hsa-miR-375 CCDC80 -3.08 0 1.09 0 miRanda -0.4 0 NA
44 hsa-miR-375 CCDC88A -3.08 0 1.01 0 miRNAWalker2 validate -0.32 0 NA
45 hsa-miR-375 CCL28 -3.08 0 0.76 0 miRanda -0.24 0 NA
46 hsa-miR-375 CD200 -3.08 0 1.39 0 miRanda -0.42 0 NA
47 hsa-miR-375 CD3G -3.08 0 0.28 0.23689 miRanda -0.26 0 NA
48 hsa-miR-375 CDCA7L -3.08 0 0.54 0.0004 miRNAWalker2 validate -0.12 0.00019 NA
49 hsa-miR-375 CDKN2B -3.08 0 0.53 3.0E-5 miRNAWalker2 validate; miRNATAP -0.17 0 NA
50 hsa-miR-375 CELF2 -3.08 0 1.12 0 miRNAWalker2 validate -0.35 0 NA
51 hsa-miR-375 CFL2 -3.08 0 1.33 0 miRNAWalker2 validate -0.34 0 NA
52 hsa-miR-375 CHGB -3.08 0 1.62 0 miRNAWalker2 validate -0.32 0 NA
53 hsa-miR-375 CHODL -3.08 0 0.6 0.01606 miRanda -0.25 0 NA
54 hsa-miR-375 CHRNA7 -3.08 0 1.9 0 mirMAP -0.43 0 NA
55 hsa-miR-375 CLCA2 -3.08 0 3.75 0 MirTarget; miRanda -0.79 0 NA
56 hsa-miR-375 CLCA4 -3.08 0 2.79 0 miRNATAP -0.62 0 NA
57 hsa-miR-375 CLDN1 -3.08 0 0.92 2.0E-5 miRNAWalker2 validate -0.4 0 25001509 Claudin 1 is a novel target of miR 375 in non small cell lung cancer; Claudin-1 CLDN1 has 4 putative miR-375 target sites in its 3'-untranslated region and this gene was determined to be a target of miR-375; CLDN1 messenger RNA and protein expression were attenuated by overexpression of miR-375 and increased by knockdown of miR-375 in NSCLC cell lines; In clinical NSCLC samples there was a negative correlation between miR-375 and CLDN1 expression r=-0.35 P=0.005; CLDN1 is a novel target of miR-375 and high miR-375 expression shortens survival in NSCLC
58 hsa-miR-375 CLEC2B -3.08 0 0.51 7.0E-5 miRanda -0.2 0 NA
59 hsa-miR-375 CNN3 -3.08 0 0.45 5.0E-5 miRNAWalker2 validate; miRanda -0.13 0 NA
60 hsa-miR-375 CNRIP1 -3.08 0 0.93 0 miRanda -0.31 0 NA
61 hsa-miR-375 COL8A1 -3.08 0 -0.13 0.54236 miRanda -0.2 1.0E-5 NA
62 hsa-miR-375 CORO1C -3.08 0 0.91 0 miRNAWalker2 validate -0.29 0 NA
63 hsa-miR-375 CPEB1 -3.08 0 2.02 0 miRanda -0.61 0 NA
64 hsa-miR-375 CPNE8 -3.08 0 0.72 0 miRanda; miRNATAP -0.25 0 NA
65 hsa-miR-375 CPPED1 -3.08 0 0.49 0 miRNATAP -0.12 0 NA
66 hsa-miR-375 CRABP2 -3.08 0 2.01 0 miRNAWalker2 validate -0.59 0 NA
67 hsa-miR-375 CRIM1 -3.08 0 0.65 0 miRNAWalker2 validate -0.22 0 NA
68 hsa-miR-375 CRYBG3 -3.08 0 0.57 1.0E-5 miRNATAP -0.15 0 NA
69 hsa-miR-375 CTDSP2 -3.08 0 0.24 0.00016 miRNAWalker2 validate -0.11 0 NA
70 hsa-miR-375 CTGF -3.08 0 0.37 0.06738 miRNAWalker2 validate; miRanda -0.24 0 NA
71 hsa-miR-375 CTNNA2 -3.08 0 0.52 0.10921 miRanda -0.36 0 NA
72 hsa-miR-375 CTSC -3.08 0 0.1 0.39159 miRNAWalker2 validate -0.18 0 NA
73 hsa-miR-375 CX3CR1 -3.08 0 0.9 0 miRanda -0.32 0 NA
74 hsa-miR-375 CXCL12 -3.08 0 0.78 0 PITA; miRanda -0.24 0 NA
75 hsa-miR-375 CXCL6 -3.08 0 1.52 0 miRanda -0.52 0 NA
76 hsa-miR-375 CYBB -3.08 0 0.14 0.39968 miRanda -0.18 0 NA
77 hsa-miR-375 CYP7B1 -3.08 0 0.52 0.0002 miRanda -0.15 0 NA
78 hsa-miR-375 CYS1 -3.08 0 0.88 0 miRanda -0.31 0 NA
79 hsa-miR-375 CYTL1 -3.08 0 1.22 0 miRanda -0.34 0 NA
80 hsa-miR-375 DCHS2 -3.08 0 2.06 0 miRanda -0.73 0 NA
81 hsa-miR-375 DCUN1D4 -3.08 0 0.55 0 miRNAWalker2 validate; miRanda -0.15 0 NA
82 hsa-miR-375 DFNA5 -3.08 0 0.87 0 miRanda -0.33 0 NA
83 hsa-miR-375 DGKH -3.08 0 0.9 0 PITA; miRanda -0.25 0 NA
84 hsa-miR-375 DIO2 -3.08 0 -0.21 0.177 mirMAP -0.13 4.0E-5 NA
85 hsa-miR-375 DIP2C -3.08 0 0.44 0 miRNAWalker2 validate; miRanda; miRNATAP -0.12 0 NA
86 hsa-miR-375 DIRAS3 -3.08 0 0.93 0 miRanda -0.33 0 NA
87 hsa-miR-375 DLG4 -3.08 0 0.92 0 miRNAWalker2 validate -0.27 0 NA
88 hsa-miR-375 DMD -3.08 0 1.67 0 miRanda -0.52 0 NA
89 hsa-miR-375 DNAH11 -3.08 0 0.97 4.0E-5 miRNAWalker2 validate -0.35 0 NA
90 hsa-miR-375 DOCK5 -3.08 0 0.53 0.00014 miRanda -0.17 0 NA
91 hsa-miR-375 DOK7 -3.08 0 0.99 0 miRNAWalker2 validate -0.34 0 NA
92 hsa-miR-375 DPY19L1 -3.08 0 0.61 0 miRNAWalker2 validate -0.18 0 NA
93 hsa-miR-375 DPYSL2 -3.08 0 0.7 0 PITA; miRanda -0.27 0 NA
94 hsa-miR-375 DPYSL3 -3.08 0 1.16 0 miRNAWalker2 validate -0.35 0 NA
95 hsa-miR-375 DUSP6 -3.08 0 0.65 0 miRNAWalker2 validate; miRanda -0.22 0 NA
96 hsa-miR-375 EBF3 -3.08 0 0.24 0.11551 miRanda; miRNATAP -0.14 2.0E-5 NA
97 hsa-miR-375 EDIL3 -3.08 0 1.78 0 miRanda -0.55 0 NA
98 hsa-miR-375 EDN3 -3.08 0 2.3 0 miRanda -0.51 0 NA
99 hsa-miR-375 EFNB3 -3.08 0 0.96 0 miRanda -0.2 0 NA
100 hsa-miR-375 EGFR -3.08 0 0.88 0 miRanda -0.23 0 NA
101 hsa-miR-375 EIF4EBP2 -3.08 0 0.6 0 miRNAWalker2 validate -0.17 0 NA
102 hsa-miR-375 ELAVL3 -3.08 0 1.9 0 miRNATAP -0.35 0 NA
103 hsa-miR-375 EMP1 -3.08 0 0.26 0.1003 miRNAWalker2 validate -0.15 1.0E-5 NA
104 hsa-miR-375 ENAH -3.08 0 0.63 0 miRNAWalker2 validate; miRNATAP -0.18 0 NA
105 hsa-miR-375 ERC1 -3.08 0 0.63 0 miRNATAP -0.18 0 NA
106 hsa-miR-375 ESPNL -3.08 0 1.4 0 miRNAWalker2 validate -0.51 0 NA
107 hsa-miR-375 EXT1 -3.08 0 0.43 0 miRNAWalker2 validate -0.14 0 NA
108 hsa-miR-375 FAM153A -3.08 0 0.39 0.02611 miRanda -0.19 0 NA
109 hsa-miR-375 FAM153B -3.08 0 0.32 0.08831 miRanda -0.13 0.00067 NA
110 hsa-miR-375 FAM155A -3.08 0 1.03 1.0E-5 miRanda -0.27 0 NA
111 hsa-miR-375 FAM167A -3.08 0 1.93 0 mirMAP -0.58 0 NA
112 hsa-miR-375 FAM63B -3.08 0 0.62 0.00011 miRNAWalker2 validate -0.14 5.0E-5 NA
113 hsa-miR-375 FAM89A -3.08 0 0.58 0 miRNAWalker2 validate -0.2 0 NA
114 hsa-miR-375 FBN1 -3.08 0 0.62 6.0E-5 mirMAP -0.31 0 NA
115 hsa-miR-375 FBN2 -3.08 0 1.04 0 miRanda -0.28 0 NA
116 hsa-miR-375 FBXL21 -3.08 0 2.39 0 miRanda -0.42 0 NA
117 hsa-miR-375 FER -3.08 0 0.96 0 miRanda -0.29 0 NA
118 hsa-miR-375 FHAD1 -3.08 0 0.93 0 miRanda -0.32 0 NA
119 hsa-miR-375 FHL5 -3.08 0 1.14 0 miRanda -0.35 0 NA
120 hsa-miR-375 FILIP1 -3.08 0 1.82 0 miRanda -0.54 0 NA
121 hsa-miR-375 FKBP1B -3.08 0 0.18 0.3815 miRNAWalker2 validate -0.12 0.00594 NA
122 hsa-miR-375 FLRT3 -3.08 0 1.84 0 PITA; miRanda -0.56 0 NA
123 hsa-miR-375 FOLR1 -3.08 0 2.65 0 miRNAWalker2 validate -0.78 0 NA
124 hsa-miR-375 FOXC1 -3.08 0 0.64 0 miRanda -0.26 0 NA
125 hsa-miR-375 FOXF1 -3.08 0 1.02 0 miRanda -0.32 0 NA
126 hsa-miR-375 FOXP2 -3.08 0 1.86 0 miRanda -0.54 0 NA
127 hsa-miR-375 FRMD6 -3.08 0 1.65 0 miRanda -0.47 0 NA
128 hsa-miR-375 FUT8 -3.08 0 0.31 0.0001 miRanda -0.15 0 NA
129 hsa-miR-375 GADD45A -3.08 0 0.9 0 miRanda -0.31 0 NA
130 hsa-miR-375 GALM -3.08 0 0.66 7.0E-5 miRNAWalker2 validate -0.28 0 NA
131 hsa-miR-375 GAP43 -3.08 0 -0.18 0.4862 miRanda -0.14 0.01047 NA
132 hsa-miR-375 GAPT -3.08 0 0.51 0.00162 miRanda -0.23 0 NA
133 hsa-miR-375 GAS7 -3.08 0 0.74 0 mirMAP -0.34 0 NA
134 hsa-miR-375 GNAO1 -3.08 0 2.19 0 miRanda -0.68 0 NA
135 hsa-miR-375 GPM6B -3.08 0 1.23 0 miRanda -0.35 0 NA
136 hsa-miR-375 GPR146 -3.08 0 0.38 1.0E-5 miRanda -0.13 0 NA
137 hsa-miR-375 GPR157 -3.08 0 0.35 0.03477 miRNAWalker2 validate; mirMAP -0.12 0.00037 NA
138 hsa-miR-375 GRAMD1B -3.08 0 1.28 0 miRanda -0.44 0 NA
139 hsa-miR-375 GRIA2 -3.08 0 1.33 0 miRanda -0.41 0 NA
140 hsa-miR-375 GRIA3 -3.08 0 1.6 0 miRanda -0.49 0 NA
141 hsa-miR-375 GRIK2 -3.08 0 0.92 0 miRanda; miRNATAP -0.25 0 NA
142 hsa-miR-375 GRIK3 -3.08 0 0.63 0.00211 miRanda -0.29 0 NA
143 hsa-miR-375 GRIK5 -3.08 0 0.92 0 miRNATAP -0.38 0 NA
144 hsa-miR-375 GTF2A1 -3.08 0 0.76 0.00088 miRanda -0.2 4.0E-5 NA
145 hsa-miR-375 HAS2 -3.08 0 1.14 0 miRNATAP -0.32 0 NA
146 hsa-miR-375 HAS3 -3.08 0 1 0 miRanda -0.34 0 NA
147 hsa-miR-375 HECTD2 -3.08 0 0.96 0 miRanda -0.23 0 NA
148 hsa-miR-375 HOXA7 -3.08 0 1.32 0 miRanda -0.4 0 NA
149 hsa-miR-375 HOXB3 -3.08 0 1.31 0 PITA; miRanda -0.49 0 27186281 Deregulation of MicroRNA 375 inhibits cancer proliferation migration and chemosensitivity in pancreatic cancer through the association of HOXB3; HOXB3 was also downregulated in Capan-1 and PANC-1 cells to assess its functional correlation with miR-375 on cancer regulation; HOXB3 was directly bound by miR-375 and was negatively regulated by miR-375 in pancreatic cancer cells; Subsequent HOXB3 downregulation reversed the suppression of miR-375 downregulation on cancer proliferation migration and cisplatin chemosensitivity in pancreatic cancer; Deregulation of miR-375 is inhibitory to the development of pancreatic cancer and reversely regulated by HOXB3
150 hsa-miR-375 HOXB9 -3.08 0 0.33 0.17755 miRanda -0.32 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 74 1402 2.547e-15 1.185e-11
2 REGULATION OF CELL DIFFERENTIATION 75 1492 2.057e-14 4.786e-11
3 CELL DEVELOPMENT 72 1426 6.123e-14 9.498e-11
4 LOCOMOTION 61 1114 2.202e-13 2.562e-10
5 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 37 513 8.271e-12 5.498e-09
6 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 63 1275 7.589e-12 5.498e-09
7 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 59 1142 6.454e-12 5.498e-09
8 NEURON PROJECTION DEVELOPMENT 38 545 1.169e-11 6.799e-09
9 CELLULAR COMPONENT MORPHOGENESIS 50 900 2.5e-11 1.293e-08
10 POSITIVE REGULATION OF CELL DIFFERENTIATION 47 823 4.153e-11 1.933e-08
11 REGULATION OF CELLULAR COMPONENT MOVEMENT 45 771 5.507e-11 2.329e-08
12 NEURON DIFFERENTIATION 48 874 9.667e-11 3.748e-08
13 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 2.092e-10 6.954e-08
14 TISSUE DEVELOPMENT 67 1518 2.083e-10 6.954e-08
15 NEURON DEVELOPMENT 40 687 7.522e-10 2.193e-07
16 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 70 1672 7.54e-10 2.193e-07
17 CARDIOVASCULAR SYSTEM DEVELOPMENT 43 788 1.215e-09 3.142e-07
18 CIRCULATORY SYSTEM DEVELOPMENT 43 788 1.215e-09 3.142e-07
19 NEURON PROJECTION MORPHOGENESIS 29 402 1.636e-09 4.006e-07
20 MUSCLE STRUCTURE DEVELOPMENT 30 432 2.077e-09 4.831e-07
21 REGULATION OF CELL DEVELOPMENT 44 836 2.329e-09 5.161e-07
22 CELL PROJECTION ORGANIZATION 46 902 2.637e-09 5.578e-07
23 NEURON PROJECTION GUIDANCE 20 205 3.915e-09 7.919e-07
24 SKELETAL SYSTEM DEVELOPMENT 30 455 6.898e-09 1.337e-06
25 CENTRAL NERVOUS SYSTEM DEVELOPMENT 44 872 8.287e-09 1.542e-06
26 RESPONSE TO ENDOGENOUS STIMULUS 61 1450 9.481e-09 1.697e-06
27 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 59 1395 1.424e-08 2.455e-06
28 CELL MOTILITY 42 835 2.036e-08 3.157e-06
29 LOCALIZATION OF CELL 42 835 2.036e-08 3.157e-06
30 HEAD DEVELOPMENT 38 709 1.929e-08 3.157e-06
31 RESPONSE TO EXTERNAL STIMULUS 70 1821 2.572e-08 3.861e-06
32 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 39 750 2.801e-08 4.061e-06
33 REGULATION OF CELL ADHESION 35 629 2.88e-08 4.061e-06
34 REGULATION OF CELL PROLIFERATION 61 1496 2.977e-08 4.075e-06
35 TAXIS 29 464 4.004e-08 5.323e-06
36 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 68 1784 5.881e-08 7.601e-06
37 ORGAN MORPHOGENESIS 41 841 7.152e-08 8.994e-06
38 REGULATION OF HEART CONTRACTION 19 221 7.458e-08 9.133e-06
39 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 46 1008 7.658e-08 9.137e-06
40 POSITIVE REGULATION OF GENE EXPRESSION 66 1733 9.884e-08 1.15e-05
41 HEART DEVELOPMENT 28 466 1.564e-07 1.774e-05
42 REGULATION OF NEURON DIFFERENTIATION 31 554 1.631e-07 1.807e-05
43 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 67 1805 2.02e-07 2.173e-05
44 MESENCHYME DEVELOPMENT 17 190 2.055e-07 2.173e-05
45 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 68 1848 2.225e-07 2.301e-05
46 RESPONSE TO GROWTH FACTOR 28 475 2.312e-07 2.339e-05
47 NEGATIVE REGULATION OF LOCOMOTION 20 263 2.528e-07 2.503e-05
48 REGULATION OF CELL SUBSTRATE ADHESION 16 173 2.989e-07 2.898e-05
49 EMBRYO DEVELOPMENT 41 894 3.638e-07 3.454e-05
50 REGULATION OF BLOOD CIRCULATION 21 295 3.808e-07 3.543e-05
51 TUBE DEVELOPMENT 30 552 4.818e-07 4.396e-05
52 MUSCLE ORGAN DEVELOPMENT 20 277 5.779e-07 5.171e-05
53 POSITIVE REGULATION OF CELL DEVELOPMENT 27 472 6.859e-07 6.022e-05
54 RESPONSE TO ORGANIC CYCLIC COMPOUND 41 917 7.02e-07 6.049e-05
55 RESPONSE TO WOUNDING 30 563 7.275e-07 6.155e-05
56 REGULATION OF SYSTEM PROCESS 28 507 8.55e-07 7.104e-05
57 POSITIVE REGULATION OF LOCOMOTION 25 420 8.705e-07 7.106e-05
58 CARTILAGE DEVELOPMENT 14 147 1.159e-06 9.254e-05
59 REGULATION OF MEMBRANE POTENTIAL 22 343 1.173e-06 9.254e-05
60 EPITHELIUM DEVELOPMENT 41 945 1.507e-06 0.0001168
61 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 42 983 1.647e-06 0.0001256
62 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 437 1.785e-06 0.000134
63 REGULATION OF CELL PROJECTION ORGANIZATION 29 558 1.843e-06 0.0001361
64 VASCULATURE DEVELOPMENT 26 469 1.979e-06 0.0001439
65 MUSCLE TISSUE DEVELOPMENT 19 275 2.135e-06 0.0001505
66 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 33 689 2.123e-06 0.0001505
67 FOREBRAIN DEVELOPMENT 22 357 2.267e-06 0.0001553
68 MESENCHYMAL CELL DIFFERENTIATION 13 134 2.269e-06 0.0001553
69 BIOLOGICAL ADHESION 43 1032 2.347e-06 0.0001582
70 POSITIVE REGULATION OF NEURON DIFFERENTIATION 20 306 2.706e-06 0.0001799
71 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 42 1004 2.809e-06 0.0001841
72 REGULATION OF PROTEIN MODIFICATION PROCESS 61 1710 2.873e-06 0.0001857
73 DENDRITE DEVELOPMENT 10 79 3.083e-06 0.0001954
74 BLOOD VESSEL MORPHOGENESIS 22 364 3.108e-06 0.0001954
75 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 34 740 3.674e-06 0.0002272
76 BEHAVIOR 27 516 3.711e-06 0.0002272
77 REGULATION OF TRANSPORT 63 1804 3.855e-06 0.000233
78 POSITIVE REGULATION OF HEART CONTRACTION 7 35 4.265e-06 0.0002544
79 HEART MORPHOGENESIS 16 212 4.439e-06 0.0002615
80 RESPONSE TO CYTOKINE 33 714 4.533e-06 0.0002637
81 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 28 554 4.729e-06 0.0002717
82 STEM CELL DIFFERENTIATION 15 190 5.103e-06 0.0002892
83 REGULATION OF CARDIAC MUSCLE CONTRACTION 9 66 5.158e-06 0.0002892
84 POSITIVE REGULATION OF CELL ADHESION 22 376 5.234e-06 0.0002899
85 REGULATION OF ION TRANSPORT 29 592 5.835e-06 0.0003194
86 ANTERIOR POSTERIOR PATTERN SPECIFICATION 15 194 6.579e-06 0.0003519
87 CONNECTIVE TISSUE DEVELOPMENT 15 194 6.579e-06 0.0003519
88 REGULATION OF HEART RATE 10 86 6.713e-06 0.000355
89 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 25 6.845e-06 0.0003579
90 REGULATION OF MUSCLE SYSTEM PROCESS 15 195 7.003e-06 0.000362
91 SINGLE ORGANISM BEHAVIOR 22 384 7.311e-06 0.0003738
92 CELL PART MORPHOGENESIS 30 633 7.682e-06 0.0003885
93 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 35 801 7.884e-06 0.0003945
94 RESPONSE TO OXYGEN CONTAINING COMPOUND 51 1381 8.152e-06 0.0004035
95 REGULATION OF TRANSPORTER ACTIVITY 15 198 8.423e-06 0.0004126
96 SARCOMERE ORGANIZATION 6 27 1.107e-05 0.0005365
97 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 16 229 1.18e-05 0.0005652
98 REGULATION OF TRANSMEMBRANE TRANSPORT 23 426 1.19e-05 0.0005652
99 REGULATION OF EPITHELIAL CELL PROLIFERATION 18 285 1.36e-05 0.0006394
100 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 207 1.435e-05 0.0006675
101 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 44 1152 1.603e-05 0.0007387
102 POSITIVE REGULATION OF RESPONSE TO STIMULUS 64 1929 1.648e-05 0.0007519
103 NEGATIVE REGULATION OF CELL COMMUNICATION 45 1192 1.703e-05 0.0007691
104 MUSCLE CELL DIFFERENTIATION 16 237 1.809e-05 0.0008093
105 REGULATION OF CELLULAR COMPONENT BIOGENESIS 33 767 1.974e-05 0.0008749
106 REGULATION OF GROWTH 29 633 2.051e-05 0.0009003
107 REGULATION OF STRIATED MUSCLE CONTRACTION 9 79 2.295e-05 0.0009981
108 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 541 2.475e-05 0.001047
109 SMOOTH MUSCLE CONTRACTION 7 45 2.434e-05 0.001047
110 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 541 2.475e-05 0.001047
111 NEGATIVE REGULATION OF CELL DIFFERENTIATION 28 609 2.678e-05 0.001123
112 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 11 122 2.728e-05 0.001125
113 NEGATIVE REGULATION OF CELL PROLIFERATION 29 643 2.732e-05 0.001125
114 RESPONSE TO LIPID 36 888 2.919e-05 0.001191
115 REGULATION OF CARTILAGE DEVELOPMENT 8 63 2.954e-05 0.001195
116 REGULATION OF CELL ACTIVATION 24 484 3.093e-05 0.00123
117 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 18 303 3.079e-05 0.00123
118 NEGATIVE REGULATION OF GENE EXPRESSION 52 1493 3.248e-05 0.001259
119 POSITIVE REGULATION OF CELL COMMUNICATION 53 1532 3.242e-05 0.001259
120 REGULATION OF MUSCLE CONTRACTION 12 147 3.216e-05 0.001259
121 REGULATION OF PHOSPHORUS METABOLIC PROCESS 55 1618 3.669e-05 0.001411
122 RESPONSE TO AXON INJURY 7 48 3.756e-05 0.001432
123 SKELETAL SYSTEM MORPHOGENESIS 14 201 4.271e-05 0.001616
124 REGULATION OF CELLULAR LOCALIZATION 46 1277 4.337e-05 0.001627
125 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 24 498 4.86e-05 0.001809
126 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 52 1517 4.934e-05 0.001822
127 REGULATION OF IMMUNE SYSTEM PROCESS 49 1403 5.236e-05 0.001919
128 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 15 232 5.411e-05 0.001967
129 POSITIVE REGULATION OF HEART RATE 5 22 5.504e-05 0.001985
130 REGULATION OF NEURON PROJECTION DEVELOPMENT 21 408 5.691e-05 0.002037
131 REGULATION OF DEVELOPMENTAL GROWTH 17 289 5.758e-05 0.002045
132 REGULATION OF KINASE ACTIVITY 32 776 5.958e-05 0.002088
133 REGULATION OF MAP KINASE ACTIVITY 18 319 6.014e-05 0.002088
134 POST EMBRYONIC DEVELOPMENT 9 89 5.974e-05 0.002088
135 POSITIVE REGULATION OF CELL PROLIFERATION 33 814 6.334e-05 0.002183
136 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 8 70 6.395e-05 0.002188
137 CELL CELL ADHESION 27 608 6.724e-05 0.002284
138 ACTIN FILAMENT BASED PROCESS 22 450 8.12e-05 0.002735
139 CARDIAC MUSCLE TISSUE MORPHOGENESIS 7 54 8.171e-05 0.002735
140 IONOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAY 5 24 8.604e-05 0.002843
141 MESENCHYME MORPHOGENESIS 6 38 8.614e-05 0.002843
142 UROGENITAL SYSTEM DEVELOPMENT 17 299 8.747e-05 0.002851
143 REGULATION OF CELL DEATH 50 1472 8.761e-05 0.002851
144 CARDIAC MUSCLE TISSUE DEVELOPMENT 11 140 9.65e-05 0.003118
145 REGULATION OF RECEPTOR ACTIVITY 10 117 9.91e-05 0.00318
146 CELLULAR RESPONSE TO LIPID 22 457 0.0001015 0.003235
147 GLAND DEVELOPMENT 20 395 0.0001064 0.003346
148 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 5 25 0.0001058 0.003346
149 DEVELOPMENTAL PIGMENTATION 6 40 0.0001159 0.003619
150 GLAND MORPHOGENESIS 9 97 0.0001172 0.003634
151 CELL MIGRATION INVOLVED IN HEART DEVELOPMENT 4 14 0.0001221 0.003761
152 IMMUNE SYSTEM PROCESS 62 1984 0.0001297 0.003969
153 POSITIVE REGULATION OF ATPASE ACTIVITY 6 41 0.0001336 0.004062
154 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 9 99 0.0001372 0.004091
155 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 9 99 0.0001372 0.004091
156 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 9 99 0.0001372 0.004091
157 RESPONSE TO OXYGEN LEVELS 17 311 0.0001407 0.00417
158 REGULATION OF ACTIN FILAMENT BASED PROCESS 17 312 0.0001462 0.004306
159 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 8 79 0.0001518 0.004414
160 POSITIVE REGULATION OF MAPK CASCADE 22 470 0.0001516 0.004414
161 DENDRITE MORPHOGENESIS 6 42 0.0001533 0.004416
162 EMBRYONIC ORGAN DEVELOPMENT 20 406 0.0001538 0.004416
163 STRIATED MUSCLE CELL DIFFERENTIATION 12 173 0.000155 0.004425
164 DIGESTIVE SYSTEM DEVELOPMENT 11 148 0.0001583 0.004451
165 CELLULAR RESPONSE TO CYTOKINE STIMULUS 26 606 0.0001588 0.004451
166 CELL FATE COMMITMENT 14 227 0.000157 0.004451
167 CELLULAR HOMEOSTASIS 28 676 0.0001607 0.004478
168 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 4 15 0.0001639 0.004497
169 EMBRYONIC MORPHOGENESIS 24 539 0.0001634 0.004497
170 TELENCEPHALON DEVELOPMENT 14 228 0.0001643 0.004497
171 CELLULAR RESPONSE TO ACID CHEMICAL 12 175 0.0001727 0.004698
172 REGULATION OF ATPASE ACTIVITY 7 61 0.0001791 0.004845
173 RIBONUCLEOTIDE CATABOLIC PROCESS 5 28 0.0001866 0.005018
174 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 14 232 0.0001969 0.005264
175 CARDIAC VENTRICLE MORPHOGENESIS 7 62 0.0001985 0.005279
176 CARDIAC CHAMBER MORPHOGENESIS 9 104 0.0001999 0.005285
177 REGULATION OF PHOSPHATASE ACTIVITY 10 128 0.0002086 0.005453
178 MUSCLE CELL DEVELOPMENT 10 128 0.0002086 0.005453
179 PIGMENT CELL DIFFERENTIATION 5 29 0.0002219 0.005736
180 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 40 1135 0.0002214 0.005736
181 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 37 1021 0.0002243 0.005736
182 POSITIVE REGULATION OF MAP KINASE ACTIVITY 13 207 0.0002242 0.005736
183 REGULATION OF TRANSFERASE ACTIVITY 35 946 0.0002261 0.005748
184 NEGATIVE REGULATION OF CELL DEATH 33 872 0.0002281 0.005769
185 SYNAPTIC VESICLE LOCALIZATION 9 106 0.0002309 0.005777
186 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 31 799 0.0002302 0.005777
187 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 53 1656 0.000238 0.005922
188 REGULATION OF CALCIUM ION TRANSPORT 13 209 0.0002462 0.006094
189 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 33 876 0.0002478 0.0061
190 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 10 131 0.0002519 0.00617
191 INTRASPECIES INTERACTION BETWEEN ORGANISMS 6 46 0.0002563 0.00618
192 SOCIAL BEHAVIOR 6 46 0.0002563 0.00618
193 NEGATIVE REGULATION OF PHOSPHORYLATION 20 422 0.0002555 0.00618
194 REGULATION OF CELL GROWTH 19 391 0.0002655 0.006368
195 SYNAPTIC SIGNALING 20 424 0.0002717 0.006483
196 CYCLIC NUCLEOTIDE CATABOLIC PROCESS 4 17 0.0002771 0.006578
197 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 0.000297 0.006808
198 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 0.000297 0.006808
199 VIRAL ENTRY INTO HOST CELL 8 87 0.000297 0.006808
200 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 8 87 0.000297 0.006808
201 MOVEMENT IN HOST ENVIRONMENT 8 87 0.000297 0.006808
202 ENTRY INTO HOST 8 87 0.000297 0.006808
203 ENTRY INTO HOST CELL 8 87 0.000297 0.006808
204 MODULATION OF SYNAPTIC TRANSMISSION 16 301 0.0003003 0.006849
205 INTERACTION WITH HOST 10 134 0.0003025 0.006867
206 POSITIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 5 31 0.0003075 0.006945
207 SECOND MESSENGER MEDIATED SIGNALING 11 160 0.0003124 0.007022
208 NEGATIVE REGULATION OF CELL DEVELOPMENT 16 303 0.0003232 0.00723
209 MYOFIBRIL ASSEMBLY 6 48 0.000325 0.007236
210 RESPONSE TO STEROID HORMONE 22 497 0.0003297 0.007305
211 EXTRACELLULAR STRUCTURE ORGANIZATION 16 304 0.0003352 0.007392
212 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 21 465 0.0003444 0.007558
213 TISSUE MORPHOGENESIS 23 533 0.0003478 0.007591
214 RESPONSE TO HORMONE 33 893 0.0003491 0.007591
215 HINDBRAIN DEVELOPMENT 10 137 0.0003614 0.007748
216 SKELETAL MUSCLE ORGAN DEVELOPMENT 10 137 0.0003614 0.007748
217 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 45 1360 0.0003593 0.007748
218 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 6 49 0.0003643 0.007776
219 OVULATION CYCLE 9 113 0.0003726 0.007881
220 CELLULAR CHEMICAL HOMEOSTASIS 24 570 0.000371 0.007881
221 SYNAPTIC VESICLE CYCLE 8 90 0.0003746 0.007887
222 WOUND HEALING 21 470 0.0003965 0.008273
223 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 21 470 0.0003965 0.008273
224 REGULATION OF ANATOMICAL STRUCTURE SIZE 21 472 0.0004192 0.008708
225 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 19 406 0.0004234 0.008721
226 MUSCLE ORGAN MORPHOGENESIS 7 70 0.0004236 0.008721
227 REGIONALIZATION 16 311 0.0004306 0.008827
228 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 8 92 0.0004349 0.008876
229 MUSCLE SYSTEM PROCESS 15 282 0.0004568 0.009282
230 HOMEOSTATIC PROCESS 44 1337 0.0004692 0.009451
231 POSITIVE REGULATION OF BLOOD CIRCULATION 8 93 0.0004679 0.009451
232 VESICLE LOCALIZATION 13 224 0.0004792 0.009611
233 APPENDAGE DEVELOPMENT 11 169 0.0004978 0.009898
234 LIMB DEVELOPMENT 11 169 0.0004978 0.009898
NumGOOverlapSizeP ValueAdj. P Value
1 GATED CHANNEL ACTIVITY 23 325 1.175e-07 0.0001091
2 LIGAND GATED CHANNEL ACTIVITY 14 142 7.617e-07 0.0002617
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 32 629 8.451e-07 0.0002617
4 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 25 464 5.148e-06 0.001196
5 TRANSMITTER GATED CHANNEL ACTIVITY 6 26 8.753e-06 0.001626
6 EXCITATORY EXTRACELLULAR LIGAND GATED ION CHANNEL ACTIVITY 8 55 1.064e-05 0.001647
7 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 28 588 1.425e-05 0.001891
8 TRANSCRIPTION COREPRESSOR ACTIVITY 15 221 3.095e-05 0.003454
9 EXTRACELLULAR GLUTAMATE GATED ION CHANNEL ACTIVITY 5 20 3.347e-05 0.003454
10 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 9 90 6.525e-05 0.006062
11 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 43 1199 8.646e-05 0.006179
12 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 18 328 8.58e-05 0.006179
13 TRANSCRIPTION COACTIVATOR ACTIVITY 17 296 7.733e-05 0.006179
14 RECEPTOR BINDING 50 1476 9.367e-05 0.006216
15 EXTRACELLULAR LIGAND GATED ION CHANNEL ACTIVITY 8 75 0.000105 0.006504
16 REGULATORY REGION NUCLEIC ACID BINDING 32 818 0.0001574 0.008125
17 GLUTAMATE RECEPTOR ACTIVITY 5 27 0.0001557 0.008125
18 SEQUENCE SPECIFIC DNA BINDING 38 1037 0.0001473 0.008125
19 FIBRONECTIN BINDING 5 28 0.0001866 0.009123
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE REGION 51 1134 2.226e-08 1.3e-05
2 PLASMA MEMBRANE PROTEIN COMPLEX 30 510 8.857e-08 2.586e-05
3 CELL JUNCTION 48 1151 5.606e-07 0.0001091
4 PLASMA MEMBRANE REGION 41 929 9.785e-07 0.0001429
5 SYNAPSE 34 754 5.494e-06 0.0005417
6 TRANSPORTER COMPLEX 20 321 5.565e-06 0.0005417
7 DENDRITE CYTOPLASM 5 16 1.006e-05 0.0007522
8 SYNAPSE PART 29 610 1.03e-05 0.0007522
9 NEURON PART 47 1265 1.639e-05 0.0008699
10 INTRINSIC COMPONENT OF PLASMA MEMBRANE 57 1649 1.611e-05 0.0008699
11 MEMBRANE MICRODOMAIN 18 288 1.567e-05 0.0008699
12 RECEPTOR COMPLEX 19 327 2.528e-05 0.00123
13 IONOTROPIC GLUTAMATE RECEPTOR COMPLEX 7 47 3.262e-05 0.001387
14 SOMATODENDRITIC COMPARTMENT 29 650 3.324e-05 0.001387
15 PLASMA MEMBRANE RECEPTOR COMPLEX 13 175 4.109e-05 0.0016
16 CELL PROJECTION 58 1786 7.896e-05 0.002882
17 NEURON PROJECTION 36 942 9.734e-05 0.003344
18 CATION CHANNEL COMPLEX 12 167 0.000111 0.003582
19 CELL BODY 23 494 0.0001165 0.003582
20 I BAND 10 121 0.0001312 0.003832
21 AMPA GLUTAMATE RECEPTOR COMPLEX 5 27 0.0001557 0.004134
22 PRESYNAPSE 16 283 0.0001497 0.004134
23 SYNAPTIC MEMBRANE 15 261 0.0002005 0.00509

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Ferroptosis_hsa04216 6 40 0.0001159 0.006027
2 Focal_adhesion_hsa04510 12 199 0.0005582 0.01451
3 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.002299 0.03471
4 Hippo_signaling_pathway_hsa04390 9 154 0.003297 0.03471
5 Neuroactive_ligand_receptor_interaction_hsa04080 13 278 0.003338 0.03471
6 cAMP_signaling_pathway_hsa04024 10 198 0.005641 0.04203
7 Peroxisome_hsa04146 6 83 0.005658 0.04203
8 Calcium_signaling_pathway_hsa04020 9 182 0.009612 0.06248
9 Adherens_junction_hsa04520 5 72 0.01323 0.07068
10 HIF_1_signaling_pathway_hsa04066 6 100 0.01359 0.07068
11 Rap1_signaling_pathway_hsa04015 9 206 0.0201 0.08992
12 ECM_receptor_interaction_hsa04512 5 82 0.02207 0.08992
13 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.02378 0.08992
14 TGF_beta_signaling_pathway_hsa04350 5 84 0.02421 0.08992
15 p53_signaling_pathway_hsa04115 4 68 0.04374 0.1516
16 Regulation_of_actin_cytoskeleton_hsa04810 8 208 0.0518 0.1684
17 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.06666 0.2039
18 Gap_junction_hsa04540 4 88 0.09324 0.2694
19 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.1149 0.3024
20 FoxO_signaling_pathway_hsa04068 5 132 0.1163 0.3024
21 MAPK_signaling_pathway_hsa04010 9 295 0.1246 0.3085
22 Apoptosis_multiple_species_hsa04215 2 33 0.1351 0.3193
23 PI3K_Akt_signaling_pathway_hsa04151 10 352 0.1521 0.3438
24 Sphingolipid_signaling_pathway_hsa04071 4 118 0.199 0.4201
25 Cellular_senescence_hsa04218 5 160 0.2031 0.4201
26 Jak_STAT_signaling_pathway_hsa04630 5 162 0.21 0.4201
27 ABC_transporters_hsa02010 2 45 0.2188 0.4214
28 ErbB_signaling_pathway_hsa04012 3 85 0.2305 0.4281
29 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.2756 0.4653
30 Apelin_signaling_pathway_hsa04371 4 137 0.2786 0.4653
31 Apoptosis_hsa04210 4 138 0.283 0.4653
32 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.2873 0.4653
33 Ras_signaling_pathway_hsa04014 6 232 0.2999 0.4653
34 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.3043 0.4653
35 VEGF_signaling_pathway_hsa04370 2 59 0.32 0.4755
36 Phagosome_hsa04145 4 152 0.3446 0.4952
37 TNF_signaling_pathway_hsa04668 3 108 0.3523 0.4952
38 Necroptosis_hsa04217 4 164 0.3976 0.5441
39 Cell_cycle_hsa04110 3 124 0.4364 0.5818
40 Endocytosis_hsa04144 5 244 0.5183 0.6738
41 Wnt_signaling_pathway_hsa04310 3 146 0.5444 0.6904
42 cGMP_PKG_signaling_pathway_hsa04022 3 163 0.619 0.7486
43 Tight_junction_hsa04530 3 170 0.6473 0.765
44 AMPK_signaling_pathway_hsa04152 2 121 0.6865 0.7668
45 Lysosome_hsa04142 2 123 0.6952 0.7668
46 Oocyte_meiosis_hsa04114 2 124 0.6994 0.7668
47 Autophagy_animal_hsa04140 2 128 0.7159 0.7668
48 mTOR_signaling_pathway_hsa04150 2 151 0.7965 0.8284

Quest ID: 46674aa31ca3011d9c4cf5df053af34c