Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p AAAS -0.14 0.04976 0.33 0 miRNAWalker2 validate -0.19 0 NA
2 hsa-miR-342-3p AADAC 1.22 0 -4.47 0 miRanda -0.67 0 NA
3 hsa-miR-28-5p AAGAB -0.14 0.04976 0.81 0 miRanda -0.26 0 NA
4 hsa-miR-28-5p AATK -0.14 0.04976 0.45 0.00408 miRanda -0.27 0.00027 NA
5 hsa-miR-342-3p ABCA13 1.22 0 -1.78 0 miRanda -0.5 0 NA
6 hsa-miR-342-3p ABCA6 1.22 0 -3.37 0 miRanda -0.3 0 NA
7 hsa-miR-28-5p ABCB9 -0.14 0.04976 0.95 0 miRanda -0.26 0 NA
8 hsa-miR-28-5p ABCC5 -0.14 0.04976 0.8 0 miRanda; mirMAP -0.16 0.00553 NA
9 hsa-miR-342-3p ABCC9 1.22 0 -2.42 0 miRanda -0.26 0 NA
10 hsa-miR-28-5p ABHD1 -0.14 0.04976 -0.98 0 miRanda -0.3 7.0E-5 NA
11 hsa-miR-28-5p ABHD2 -0.14 0.04976 0.45 0.00053 mirMAP -0.25 5.0E-5 NA
12 hsa-miR-28-5p ABLIM3 -0.14 0.04976 -1.88 0 miRanda -0.64 0 NA
13 hsa-miR-28-5p ACACA -0.14 0.04976 -0.22 0.02162 miRanda -0.16 0.00043 NA
14 hsa-miR-28-5p ACAD8 -0.14 0.04976 -0.36 0 miRanda -0.12 0.00017 NA
15 hsa-miR-28-5p ACAT1 -0.14 0.04976 -0.75 0 miRanda -0.16 0.00027 NA
16 hsa-miR-28-5p ACE -0.14 0.04976 -0.33 0.00163 mirMAP -0.12 0.02054 NA
17 hsa-miR-342-3p ACER3 1.22 0 -0.64 0 miRanda -0.1 0.00023 NA
18 hsa-miR-28-5p ACOX3 -0.14 0.04976 0.2 0.02327 miRanda -0.18 1.0E-5 NA
19 hsa-miR-28-5p ACSF2 -0.14 0.04976 -0.26 0.05489 miRanda -0.31 0 NA
20 hsa-miR-342-3p ACSL4 1.22 0 -1.48 0 MirTarget; miRanda -0.26 0 NA
21 hsa-miR-342-3p ACVRL1 1.22 0 -0.99 0 miRanda -0.16 0 NA
22 hsa-miR-342-3p ADAM9 1.22 0 -0.03 0.77501 miRanda -0.14 0 NA
23 hsa-miR-342-3p ADAMTS1 1.22 0 -2.52 0 miRanda -0.41 0 NA
24 hsa-miR-28-5p ADAMTS13 -0.14 0.04976 0.49 0.00058 miRanda -0.25 0.0002 NA
25 hsa-miR-28-5p ADAMTS15 -0.14 0.04976 -0.94 0.00099 mirMAP -1.13 0 NA
26 hsa-miR-342-3p ADARB1 1.22 0 -0.6 0 miRanda -0.13 0 NA
27 hsa-miR-28-5p ADCK1 -0.14 0.04976 0.19 0.00451 miRanda -0.12 0.00012 NA
28 hsa-miR-28-5p ADCY1 -0.14 0.04976 -0.05 0.84149 miRanda -0.59 0 NA
29 hsa-miR-342-3p ADCY2 1.22 0 -0.73 0.00385 miRanda -0.39 0 NA
30 hsa-miR-342-3p ADCY3 1.22 0 -0.58 0 miRanda -0.14 0 NA
31 hsa-miR-28-5p ADCY6 -0.14 0.04976 -0.63 0 miRanda -0.32 0 NA
32 hsa-miR-28-5p ADCY9 -0.14 0.04976 0.12 0.23839 mirMAP -0.4 0 NA
33 hsa-miR-342-3p ADH1B 1.22 0 -7.23 0 miRanda -0.54 2.0E-5 NA
34 hsa-miR-342-3p ADI1 1.22 0 -0.35 3.0E-5 miRanda -0.14 0 NA
35 hsa-miR-342-3p ADORA2B 1.22 0 -0.76 0 miRanda -0.34 0 NA
36 hsa-miR-342-3p ADRA1A 1.22 0 -4.75 0 miRanda -0.46 0 NA
37 hsa-miR-342-3p ADRA2B 1.22 0 -1.36 0 miRanda -0.24 0 NA
38 hsa-miR-342-3p ADRB1 1.22 0 -2.83 0 PITA; miRanda -0.29 2.0E-5 NA
39 hsa-miR-28-5p AFF1 -0.14 0.04976 -0.82 0 miRanda -0.18 2.0E-5 NA
40 hsa-miR-342-3p AFF2 1.22 0 -1.78 0 mirMAP -0.32 0 NA
41 hsa-miR-28-5p AFF4 -0.14 0.04976 -0.28 0.00153 MirTarget; miRanda -0.2 0 NA
42 hsa-miR-28-5p AFTPH -0.14 0.04976 0.31 0 miRanda -0.1 0.00074 NA
43 hsa-miR-28-5p AGAP11 -0.14 0.04976 -2.72 0 miRanda -0.31 0.00022 NA
44 hsa-miR-342-3p AGAP11 1.22 0 -2.72 0 miRanda -0.12 0.00734 NA
45 hsa-miR-28-5p AGBL4 -0.14 0.04976 -0.14 0.45129 miRanda -0.24 0.00912 NA
46 hsa-miR-342-3p AGPAT4 1.22 0 -0.74 0 MirTarget -0.32 0 NA
47 hsa-miR-28-5p AHNAK -0.14 0.04976 -1.77 0 PITA; miRanda; miRNATAP -0.27 0 NA
48 hsa-miR-342-3p AIFM2 1.22 0 -1.44 0 miRanda -0.15 0 NA
49 hsa-miR-342-3p AK5 1.22 0 -3.09 0 miRanda -0.19 0.00828 NA
50 hsa-miR-342-3p AKAP7 1.22 0 -1.02 0 miRanda -0.13 0 NA
51 hsa-miR-342-3p AKR1B1 1.22 0 -0.51 0 miRanda -0.18 0 NA
52 hsa-miR-28-5p AKR7A2 -0.14 0.04976 0.34 1.0E-5 miRanda -0.24 0 NA
53 hsa-miR-28-5p ALDH3A2 -0.14 0.04976 -0.86 0 miRanda -0.29 0 NA
54 hsa-miR-342-3p ALS2CL 1.22 0 -1.15 0 mirMAP -0.21 0 NA
55 hsa-miR-342-3p ALS2CR11 1.22 0 -1.63 0 miRanda -0.13 0.00564 NA
56 hsa-miR-342-3p ALX4 1.22 0 -3.22 0 mirMAP -0.43 0 NA
57 hsa-miR-28-5p AMIGO2 -0.14 0.04976 -1.58 0 miRanda -0.24 0.00784 NA
58 hsa-miR-342-3p AMOT 1.22 0 -0.91 0 miRanda -0.13 3.0E-5 NA
59 hsa-miR-28-5p AMPH -0.14 0.04976 -0.23 0.25767 MirTarget; PITA; miRanda -0.38 8.0E-5 NA
60 hsa-miR-28-5p AMZ1 -0.14 0.04976 2.49 0 miRanda -0.45 0.00014 NA
61 hsa-miR-28-5p ANGEL1 -0.14 0.04976 -0.24 5.0E-5 miRanda -0.14 0 NA
62 hsa-miR-342-3p ANGPTL1 1.22 0 -3.72 0 miRanda -0.33 0 NA
63 hsa-miR-342-3p ANGPTL2 1.22 0 -1.92 0 miRanda -0.31 0 NA
64 hsa-miR-342-3p ANGPTL4 1.22 0 -2.45 0 miRanda -0.52 0 NA
65 hsa-miR-342-3p ANK2 1.22 0 -2.51 0 miRanda; miRNATAP -0.28 0 NA
66 hsa-miR-342-3p ANKDD1A 1.22 0 -1.5 0 miRanda -0.15 0 NA
67 hsa-miR-28-5p ANKS1B -0.14 0.04976 0.2 0.2194 miRanda -0.42 0 NA
68 hsa-miR-28-5p ANKS3 -0.14 0.04976 0.72 0 miRanda -0.16 0.0011 NA
69 hsa-miR-342-3p ANTXR1 1.22 0 -0.18 0.16983 miRanda -0.13 2.0E-5 NA
70 hsa-miR-342-3p ANXA8 1.22 0 -2.01 0 MirTarget; miRanda -0.61 0 NA
71 hsa-miR-28-5p ANXA9 -0.14 0.04976 1.78 0 miRanda -1.05 0 NA
72 hsa-miR-28-5p AP2A2 -0.14 0.04976 0.03 0.55943 miRanda -0.12 0 NA
73 hsa-miR-28-5p AP2B1 -0.14 0.04976 0.26 0.00183 miRanda -0.22 0 NA
74 hsa-miR-28-5p APC2 -0.14 0.04976 0.94 0 mirMAP -0.27 0.00015 NA
75 hsa-miR-342-3p APOLD1 1.22 0 -1.8 0 MirTarget; miRanda -0.17 0 NA
76 hsa-miR-342-3p AQP4 1.22 0 -2.95 0 miRanda -0.35 0 NA
77 hsa-miR-28-5p ARAF -0.14 0.04976 0.24 1.0E-5 miRanda; miRNATAP -0.11 4.0E-5 NA
78 hsa-miR-342-3p ARAP3 1.22 0 -1.27 0 mirMAP -0.23 0 NA
79 hsa-miR-342-3p ARHGAP21 1.22 0 -1.05 0 miRanda -0.19 0 NA
80 hsa-miR-342-3p ARHGAP26 1.22 0 -1.51 0 mirMAP -0.16 0 NA
81 hsa-miR-28-5p ARHGAP32 -0.14 0.04976 0.43 9.0E-5 miRanda -0.36 0 NA
82 hsa-miR-28-5p ARHGAP8 -0.14 0.04976 1.29 0 miRanda -0.12 0.04559 NA
83 hsa-miR-28-5p ARHGEF16 -0.14 0.04976 1.35 0 miRanda -0.31 0 NA
84 hsa-miR-342-3p ARHGEF9 1.22 0 -0.44 0 miRanda -0.1 0 NA
85 hsa-miR-342-3p ARID5B 1.22 0 -1.75 0 PITA; miRanda -0.16 0 NA
86 hsa-miR-342-3p ARL10 1.22 0 -1.27 0 mirMAP -0.25 0 NA
87 hsa-miR-28-5p ARL17A -0.14 0.04976 -0.08 0.37677 miRanda -0.12 0.00459 NA
88 hsa-miR-28-5p ARL6IP4 -0.14 0.04976 0.5 0 miRanda -0.19 0.00019 NA
89 hsa-miR-28-5p ARMC5 -0.14 0.04976 0.67 0 miRanda -0.28 0 NA
90 hsa-miR-28-5p ARMC7 -0.14 0.04976 0.79 0 miRanda -0.13 0.00026 NA
91 hsa-miR-28-5p ARMC9 -0.14 0.04976 1.05 0 miRanda -0.18 0 NA
92 hsa-miR-342-3p ASB1 1.22 0 -0.93 0 mirMAP -0.12 0 NA
93 hsa-miR-28-5p ASB8 -0.14 0.04976 -0.21 0.00012 miRanda -0.19 0 NA
94 hsa-miR-342-3p ASTN1 1.22 0 -2.96 0 miRanda -0.35 0 NA
95 hsa-miR-342-3p ATF3 1.22 0 -2.25 0 miRanda -0.28 0 NA
96 hsa-miR-342-3p ATP10B 1.22 0 -1.05 8.0E-5 miRanda -0.46 0 NA
97 hsa-miR-342-3p ATP11A 1.22 0 -0.67 0 miRanda -0.21 0 NA
98 hsa-miR-342-3p ATP2B4 1.22 0 -1.11 0 mirMAP -0.13 0 NA
99 hsa-miR-28-5p ATP6V0E2 -0.14 0.04976 0.87 0 mirMAP -0.24 0 NA
100 hsa-miR-28-5p ATPAF1 -0.14 0.04976 -0.16 0.00532 PITA; miRanda; miRNATAP -0.12 1.0E-5 NA
101 hsa-miR-28-5p ATRNL1 -0.14 0.04976 -0.74 0.02081 MirTarget; miRanda -0.53 0.00049 NA
102 hsa-miR-342-3p ATXN1L 1.22 0 -0.97 0 miRNATAP -0.14 0 NA
103 hsa-miR-28-5p B3GALT4 -0.14 0.04976 0.46 1.0E-5 miRanda -0.14 0.00301 NA
104 hsa-miR-342-3p B3GNT3 1.22 0 -1.39 0 miRanda -0.55 0 NA
105 hsa-miR-342-3p B3GNT7 1.22 0 0.2 0.16025 MirTarget; miRanda -0.23 0 NA
106 hsa-miR-342-3p B4GALT5 1.22 0 -0.34 4.0E-5 mirMAP -0.11 0 NA
107 hsa-miR-28-5p BAG1 -0.14 0.04976 0.42 2.0E-5 miRanda -0.31 0 NA
108 hsa-miR-342-3p BAG2 1.22 0 -0.04 0.72195 miRanda -0.2 0 NA
109 hsa-miR-342-3p BBOX1 1.22 0 -3.62 0 miRanda -0.84 0 NA
110 hsa-miR-28-5p BBS1 -0.14 0.04976 -0.09 0.27359 miRanda -0.29 0 NA
111 hsa-miR-28-5p BCAM -0.14 0.04976 0.51 0.00081 PITA; miRanda -0.64 0 NA
112 hsa-miR-342-3p BCL11A 1.22 0 -1.42 0 miRanda -0.55 0 NA
113 hsa-miR-28-5p BDKRB2 -0.14 0.04976 -0.63 0 mirMAP -0.17 0.00195 NA
114 hsa-miR-28-5p BHLHE40 -0.14 0.04976 0.41 0.00047 miRanda -0.47 0 NA
115 hsa-miR-342-3p BHLHE41 1.22 0 -1.53 0 miRanda -0.2 0 NA
116 hsa-miR-342-3p BMP7 1.22 0 -0.57 0.0198 miRNAWalker2 validate; miRTarBase; miRanda -0.4 0 NA
117 hsa-miR-342-3p BNC1 1.22 0 -2.84 0 miRanda -0.45 0 NA
118 hsa-miR-342-3p BTG3 1.22 0 -0.4 0.00167 miRanda -0.25 0 NA
119 hsa-miR-28-5p BTRC -0.14 0.04976 0.12 0.15929 miRanda -0.25 0 NA
120 hsa-miR-342-3p C10orf10 1.22 0 -2.19 0 mirMAP -0.38 0 NA
121 hsa-miR-28-5p C16orf52 -0.14 0.04976 -0.44 0 miRNATAP -0.11 0.00025 NA
122 hsa-miR-342-3p C17orf51 1.22 0 -1.38 0 mirMAP -0.37 0 NA
123 hsa-miR-28-5p C17orf82 -0.14 0.04976 0.65 0.00059 mirMAP -0.4 1.0E-5 NA
124 hsa-miR-342-3p C1orf115 1.22 0 -1.55 0 mirMAP -0.15 8.0E-5 NA
125 hsa-miR-342-3p C1orf198 1.22 0 -0.18 0.02916 mirMAP -0.15 0 NA
126 hsa-miR-342-3p C3orf70 1.22 0 -0.82 0 mirMAP -0.15 1.0E-5 NA
127 hsa-miR-342-3p C6orf223 1.22 0 1.13 0.00032 mirMAP -0.28 0.00023 NA
128 hsa-miR-28-5p CA12 -0.14 0.04976 1.11 2.0E-5 mirMAP -1.23 0 NA
129 hsa-miR-342-3p CACNA1C 1.22 0 -0.83 0 MirTarget; PITA; miRanda; miRNATAP -0.12 0.00028 NA
130 hsa-miR-28-5p CACNG4 -0.14 0.04976 2.21 0 miRanda -0.63 2.0E-5 NA
131 hsa-miR-342-3p CADM3 1.22 0 -3.48 0 miRanda -0.35 0 NA
132 hsa-miR-28-5p CALCOCO1 -0.14 0.04976 -1.08 0 miRanda -0.14 8.0E-5 NA
133 hsa-miR-28-5p CALCOCO2 -0.14 0.04976 -0.44 0 miRanda -0.2 0 NA
134 hsa-miR-342-3p CAMK2D 1.22 0 -0.88 0 miRanda -0.13 0 NA
135 hsa-miR-28-5p CANT1 -0.14 0.04976 1.19 0 miRanda; miRNATAP -0.31 0 NA
136 hsa-miR-28-5p CASC2 -0.14 0.04976 -0.06 0.56145 miRanda -0.21 1.0E-5 NA
137 hsa-miR-342-3p CAV1 1.22 0 -3.35 0 miRanda -0.37 0 NA
138 hsa-miR-28-5p CBFA2T3 -0.14 0.04976 -0.24 0.18951 mirMAP -0.49 0 NA
139 hsa-miR-342-3p CBX2 1.22 0 1.77 0 mirMAP -0.17 0.00048 NA
140 hsa-miR-28-5p CCDC113 -0.14 0.04976 0.15 0.13693 miRanda; miRNATAP -0.15 0.0019 NA
141 hsa-miR-28-5p CCDC114 -0.14 0.04976 1.17 0 miRanda -0.3 0.00046 NA
142 hsa-miR-342-3p CCDC141 1.22 0 -2.66 0 miRanda -0.21 0 NA
143 hsa-miR-342-3p CCDC68 1.22 0 -2.06 0 miRanda -0.11 0.04166 NA
144 hsa-miR-28-5p CCDC85A -0.14 0.04976 -2.64 0 miRanda -0.2 0.02171 NA
145 hsa-miR-28-5p CCDC87 -0.14 0.04976 1.38 0 miRanda -0.5 0 NA
146 hsa-miR-342-3p CCL8 1.22 0 -1.17 0 miRanda -0.17 0.00081 NA
147 hsa-miR-342-3p CCND2 1.22 0 -1.32 0 miRNAWalker2 validate; mirMAP -0.1 0.00019 NA
148 hsa-miR-28-5p CCNDBP1 -0.14 0.04976 -0.73 0 miRanda -0.17 0 NA
149 hsa-miR-28-5p CCNG2 -0.14 0.04976 -0.15 0.14084 miRanda -0.2 3.0E-5 NA
150 hsa-miR-342-3p CD109 1.22 0 -0.52 0.00083 mirMAP -0.18 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 129 1492 7.87e-10 1.971e-06
2 NEUROGENESIS 123 1402 8.471e-10 1.971e-06
3 REGULATION OF NEURON DIFFERENTIATION 62 554 3.418e-09 5.301e-06
4 MUSCLE STRUCTURE DEVELOPMENT 52 432 5.611e-09 6.526e-06
5 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 107 1275 1.186e-07 9.2e-05
6 REGULATION OF NEURON PROJECTION DEVELOPMENT 47 408 1.165e-07 9.2e-05
7 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 70 750 5.022e-07 0.0002921
8 REGULATION OF CELL DEVELOPMENT 76 836 4.551e-07 0.0002921
9 BIOLOGICAL ADHESION 88 1032 8.786e-07 0.0004542
10 POSITIVE REGULATION OF NEURON DIFFERENTIATION 36 306 2.136e-06 0.0008296
11 POSITIVE REGULATION OF CELL DIFFERENTIATION 73 823 1.916e-06 0.0008296
12 TISSUE DEVELOPMENT 117 1518 2.318e-06 0.0008296
13 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 30 232 2.186e-06 0.0008296
14 REGULATION OF PHOSPHOLIPASE ACTIVITY 14 64 2.847e-06 0.0009463
15 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 81 957 3.241e-06 0.001005
16 REGULATION OF GROWTH 59 633 4.179e-06 0.001079
17 APPENDAGE DEVELOPMENT 24 169 4.407e-06 0.001079
18 LIMB DEVELOPMENT 24 169 4.407e-06 0.001079
19 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 132 1784 4.151e-06 0.001079
20 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 125 1672 4.664e-06 0.001085
21 SKELETAL SYSTEM DEVELOPMENT 46 455 6.047e-06 0.001286
22 LOCOMOTION 90 1114 6.081e-06 0.001286
23 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 37 337 7.81e-06 0.001469
24 CELL MATRIX ADHESION 19 119 7.791e-06 0.001469
25 BEHAVIOR 50 516 7.894e-06 0.001469
26 PALLIUM DEVELOPMENT 22 153 8.9e-06 0.001593
27 NEURON MIGRATION 18 110 9.454e-06 0.001629
28 MUSCLE ORGAN DEVELOPMENT 32 277 1.128e-05 0.001875
29 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 104 1360 1.24e-05 0.001965
30 CELL DEVELOPMENT 108 1426 1.267e-05 0.001965
31 CHEMICAL HOMEOSTASIS 73 874 1.574e-05 0.002254
32 REGULATION OF LIPASE ACTIVITY 15 83 1.524e-05 0.002254
33 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 90 1142 1.599e-05 0.002254
34 BLOOD VESSEL MORPHOGENESIS 38 364 1.877e-05 0.002502
35 REGULATION OF CELLULAR COMPONENT MOVEMENT 66 771 1.882e-05 0.002502
36 CARDIOVASCULAR SYSTEM DEVELOPMENT 67 788 2.018e-05 0.002538
37 CIRCULATORY SYSTEM DEVELOPMENT 67 788 2.018e-05 0.002538
38 CELLULAR COMPONENT MORPHOGENESIS 74 900 2.339e-05 0.002675
39 REGULATION OF CELL PROLIFERATION 111 1496 2.322e-05 0.002675
40 REGULATION OF CELL MORPHOGENESIS 51 552 2.357e-05 0.002675
41 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 22 162 2.231e-05 0.002675
42 ORGAN MORPHOGENESIS 70 841 2.635e-05 0.00273
43 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 12 58 2.64e-05 0.00273
44 MUSCLE CELL DIFFERENTIATION 28 237 2.601e-05 0.00273
45 CENTRAL NERVOUS SYSTEM DEVELOPMENT 72 872 2.63e-05 0.00273
46 VASCULATURE DEVELOPMENT 45 469 2.832e-05 0.002804
47 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 33 303 2.804e-05 0.002804
48 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 120 1656 3.066e-05 0.002972
49 REGULATION OF CELL PROJECTION ORGANIZATION 51 558 3.138e-05 0.00298
50 REGULATION OF AXONOGENESIS 22 168 3.941e-05 0.003667
51 SENSORY ORGAN DEVELOPMENT 46 493 4.61e-05 0.004206
52 CELL MOTILITY 68 835 6.715e-05 0.005895
53 LOCALIZATION OF CELL 68 835 6.715e-05 0.005895
54 CAMP MEDIATED SIGNALING 9 37 7.067e-05 0.006089
55 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 30 278 7.554e-05 0.006391
56 CELL SUBSTRATE ADHESION 21 164 8.138e-05 0.006529
57 REGULATION OF CHONDROCYTE DIFFERENTIATION 10 46 7.915e-05 0.006529
58 SKELETAL SYSTEM MORPHOGENESIS 24 201 8.096e-05 0.006529
59 ARTERY DEVELOPMENT 13 75 8.735e-05 0.006663
60 REGULATION OF CELL GROWTH 38 391 8.878e-05 0.006663
61 REGULATION OF ACTION POTENTIAL 9 38 8.849e-05 0.006663
62 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 8 30 8.84e-05 0.006663
63 TELENCEPHALON DEVELOPMENT 26 228 9.043e-05 0.006679
64 CELL CELL SIGNALING 63 767 9.719e-05 0.007066
65 EMBRYONIC MORPHOGENESIS 48 539 0.0001004 0.007189
66 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 41 437 0.000104 0.007332
67 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 65 801 0.0001074 0.007458
68 REGULATION OF PHOSPHOLIPASE C ACTIVITY 9 39 0.0001099 0.007522
69 REGULATION OF MICROTUBULE POLYMERIZATION 8 31 0.0001139 0.007569
70 HEAD DEVELOPMENT 59 709 0.0001133 0.007569
71 DEVELOPMENTAL CELL GROWTH 13 77 0.0001155 0.007569
72 ACTIVATION OF PROTEIN KINASE A ACTIVITY 6 17 0.0001243 0.008036
73 REGULATION OF ANATOMICAL STRUCTURE SIZE 43 472 0.000138 0.00868
74 POSITIVE REGULATION OF CELL DEVELOPMENT 43 472 0.000138 0.00868
75 FOREBRAIN DEVELOPMENT 35 357 0.00014 0.008686
76 MUSCLE TISSUE DEVELOPMENT 29 275 0.000148 0.008781
77 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 79 1036 0.0001565 0.008781
78 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 79 1036 0.0001565 0.008781
79 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 8 32 0.0001452 0.008781
80 NEGATIVE REGULATION OF CELL DIFFERENTIATION 52 609 0.000152 0.008781
81 REGULATION OF PHOSPHORUS METABOLIC PROCESS 114 1618 0.0001546 0.008781
82 CELL GROWTH 18 135 0.0001532 0.008781
83 POSITIVE REGULATION OF AXONOGENESIS 12 69 0.0001566 0.008781
84 REGULATION OF EXTENT OF CELL GROWTH 15 101 0.0001598 0.008853
85 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 78 1021 0.0001625 0.008895
86 COGNITION 27 251 0.0001785 0.009228
87 REGULATION OF SMOOTH MUSCLE CONTRACTION 11 60 0.0001798 0.009228
88 EMBRYO DEVELOPMENT 70 894 0.0001724 0.009228
89 SMOOTH MUSCLE TISSUE DEVELOPMENT 6 18 0.0001786 0.009228
90 TUBE DEVELOPMENT 48 552 0.0001767 0.009228
91 WATER HOMEOSTASIS 12 70 0.0001805 0.009228
92 VESICLE MEDIATED TRANSPORT 91 1239 0.0001865 0.009431
NumGOOverlapSizeP ValueAdj. P Value
1 CLATHRIN BINDING 13 65 1.807e-05 0.009916
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 93 1199 2.135e-05 0.009916
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE REGION 98 1134 1.073e-07 6.268e-05
2 CELL JUNCTION 98 1151 2.163e-07 6.317e-05
3 GOLGI APPARATUS PART 80 893 4.075e-07 7.932e-05
4 SYNAPSE 70 754 6.11e-07 8.921e-05
5 EXTRACELLULAR MATRIX 45 426 2.403e-06 0.0002607
6 NEURON PART 101 1265 2.678e-06 0.0002607
7 GOLGI MEMBRANE 63 703 7.069e-06 0.0005898
8 PROTEINACEOUS EXTRACELLULAR MATRIX 38 356 1.134e-05 0.0007361
9 NEURON PROJECTION 78 942 1.094e-05 0.0007361
10 GOLGI APPARATUS 109 1445 1.37e-05 0.0008003
11 COATED PIT 13 67 2.543e-05 0.001221
12 INTRINSIC COMPONENT OF PLASMA MEMBRANE 120 1649 2.54e-05 0.001221
13 CELL PROJECTION 128 1786 2.717e-05 0.001221
14 MEMBRANE MICRODOMAIN 31 288 6.059e-05 0.002527
15 PLASMA MEMBRANE REGION 74 929 6.581e-05 0.002562
16 SYNAPSE PART 52 610 0.0001583 0.005777
17 CONTRACTILE FIBER 24 211 0.0001726 0.00593
18 INTRACELLULAR VESICLE 92 1259 0.0002047 0.00664
19 ACTIN BASED CELL PROJECTION 21 181 0.0003276 0.00981
20 SYNAPTIC MEMBRANE 27 261 0.000336 0.00981

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Calcium_signaling_pathway_hsa04020 24 182 1.589e-05 0.0005893
2 cAMP_signaling_pathway_hsa04024 25 198 2.267e-05 0.0005893
3 Phospholipase_D_signaling_pathway_hsa04072 19 146 0.0001408 0.002441
4 Rap1_signaling_pathway_hsa04015 23 206 0.0003064 0.003983
5 Neuroactive_ligand_receptor_interaction_hsa04080 25 278 0.003829 0.03982
6 Gap_junction_hsa04540 11 88 0.004667 0.04044
7 Focal_adhesion_hsa04510 19 199 0.005813 0.04318
8 FoxO_signaling_pathway_hsa04068 14 132 0.006843 0.04448
9 MAPK_signaling_pathway_hsa04010 25 295 0.008051 0.04652
10 Jak_STAT_signaling_pathway_hsa04630 15 162 0.01717 0.08666
11 Regulation_of_actin_cytoskeleton_hsa04810 18 208 0.01833 0.08666
12 Endocytosis_hsa04144 20 244 0.0228 0.08913
13 Peroxisome_hsa04146 9 83 0.02379 0.08913
14 Hippo_signaling_pathway_hsa04390 14 154 0.024 0.08913
15 ErbB_signaling_pathway_hsa04012 9 85 0.02729 0.09461
16 Wnt_signaling_pathway_hsa04310 13 146 0.03345 0.1087
17 mTOR_signaling_pathway_hsa04150 13 151 0.04213 0.1289
18 PI3K_Akt_signaling_pathway_hsa04151 25 352 0.0542 0.1491
19 ECM_receptor_interaction_hsa04512 8 82 0.05449 0.1491
20 cGMP_PKG_signaling_pathway_hsa04022 13 163 0.06913 0.1744
21 Adherens_junction_hsa04520 7 72 0.07044 0.1744
22 ABC_transporters_hsa02010 5 45 0.07493 0.1771
23 AMPK_signaling_pathway_hsa04152 10 121 0.08523 0.1927
24 Mitophagy_animal_hsa04137 6 65 0.1089 0.236
25 Phosphatidylinositol_signaling_system_hsa04070 8 99 0.1268 0.2525
26 Ras_signaling_pathway_hsa04014 16 232 0.128 0.2525
27 TGF_beta_signaling_pathway_hsa04350 7 84 0.1311 0.2525
28 Cytokine_cytokine_receptor_interaction_hsa04060 18 270 0.1397 0.2594
29 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 10 139 0.1648 0.2954
30 TNF_signaling_pathway_hsa04668 8 108 0.1787 0.3098
31 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.1973 0.3309
32 Hedgehog_signaling_pathway_hsa04340 4 47 0.2116 0.3439
33 HIF_1_signaling_pathway_hsa04066 7 100 0.2403 0.3734
34 Sphingolipid_signaling_pathway_hsa04071 8 118 0.2454 0.3734
35 Apelin_signaling_pathway_hsa04371 9 137 0.2553 0.3734
36 p53_signaling_pathway_hsa04115 5 68 0.2585 0.3734
37 Cellular_senescence_hsa04218 10 160 0.2888 0.4058
38 Oocyte_meiosis_hsa04114 7 124 0.4359 0.5964
39 VEGF_signaling_pathway_hsa04370 3 59 0.5776 0.7701
40 Ferroptosis_hsa04216 2 40 0.6062 0.788
41 Autophagy_animal_hsa04140 5 128 0.7796 0.9653
42 Apoptosis_hsa04210 5 138 0.8315 1
43 Tight_junction_hsa04530 6 170 0.8638 1
44 Lysosome_hsa04142 4 123 0.8736 1
45 Necroptosis_hsa04217 5 164 0.9213 1
46 Cell_cycle_hsa04110 3 124 0.953 1

Quest ID: b100ba742da51bf3ad931dfce92964a4