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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p ABAT 1.51 0 -2.16 0 MirTarget -0.93 0 NA
2 hsa-miR-21-5p ABCA1 1.51 0 -1.1 0 mirMAP -0.29 0 NA
3 hsa-miR-21-5p ABCA10 1.51 0 -1.06 4.0E-5 mirMAP -0.45 0 NA
4 hsa-miR-21-5p ABCD3 1.51 0 -0.9 0 miRNAWalker2 validate -0.38 0 NA
5 hsa-miR-21-5p ACAT1 1.51 0 -1.62 0 miRNAWalker2 validate -0.62 0 NA
6 hsa-miR-21-5p ACBD5 1.51 0 -0.75 0 miRNAWalker2 validate; miRNATAP -0.33 0 NA
7 hsa-miR-21-5p ACVR2A 1.51 0 -0.55 0 miRNATAP -0.17 0 NA
8 hsa-miR-21-5p AIM1 1.51 0 -1.46 0 miRNAWalker2 validate -0.35 0 NA
9 hsa-miR-21-5p AKAP6 1.51 0 -0.97 0 MirTarget -0.54 0 NA
10 hsa-miR-21-5p AKAP9 1.51 0 -0.79 0 miRNAWalker2 validate -0.29 0 NA
11 hsa-miR-21-5p AKIRIN1 1.51 0 -0.73 0 miRNATAP -0.13 0.00038 NA
12 hsa-miR-21-5p AKT2 1.51 0 -0.34 1.0E-5 miRNAWalker2 validate -0.25 0 NA
13 hsa-miR-21-5p ANKRD28 1.51 0 -0.36 1.0E-5 miRNAWalker2 validate -0.17 0 NA
14 hsa-miR-21-5p ANKRD46 1.51 0 -0.78 0 miRNAWalker2 validate; miRTarBase -0.41 0 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC
15 hsa-miR-21-5p ANO3 1.51 0 -2.3 0 mirMAP -0.98 0 NA
16 hsa-miR-21-5p AP1AR 1.51 0 -0.61 0 MirTarget; miRNATAP -0.25 0 NA
17 hsa-miR-21-5p APC 1.51 0 -0.18 0.06792 miRNAWalker2 validate -0.17 0 23773491; 24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry
18 hsa-miR-21-5p APOLD1 1.51 0 0.45 0.00929 miRNAWalker2 validate -0.18 0.00545 NA
19 hsa-miR-21-5p ARHGAP21 1.51 0 -0.09 0.37274 miRNAWalker2 validate -0.11 0.00286 NA
20 hsa-miR-21-5p ARHGAP24 1.51 0 -0.99 0 MirTarget; miRNATAP -0.36 0 NA
21 hsa-miR-21-5p ARHGAP32 1.51 0 -0.2 0.09921 MirTarget -0.29 0 NA
22 hsa-miR-21-5p ARHGEF12 1.51 0 -0.86 0 miRNAWalker2 validate; MirTarget -0.26 0 NA
23 hsa-miR-21-5p ARID4A 1.51 0 -0.9 0 miRNAWalker2 validate -0.43 0 NA
24 hsa-miR-21-5p ART4 1.51 0 -1.74 0 mirMAP -0.48 1.0E-5 NA
25 hsa-miR-21-5p ASPN 1.51 0 -1.64 0 MirTarget; miRNATAP -0.2 0.04902 NA
26 hsa-miR-21-5p ATAD2B 1.51 0 -0.06 0.4791 miRNAWalker2 validate -0.14 3.0E-5 NA
27 hsa-miR-21-5p ATF2 1.51 0 -0.24 0.15619 miRNAWalker2 validate -0.18 0.00336 NA
28 hsa-miR-21-5p ATMIN 1.51 0 -0.37 0 miRNAWalker2 validate -0.12 0 NA
29 hsa-miR-21-5p ATP11B 1.51 0 -0.35 0.00133 miRNAWalker2 validate -0.16 4.0E-5 NA
30 hsa-miR-21-5p ATP2B2 1.51 0 -0.4 0.15518 mirMAP -0.24 0.01837 NA
31 hsa-miR-21-5p ATRN 1.51 0 0.12 0.34173 miRNATAP -0.17 0.00015 NA
32 hsa-miR-21-5p ATRNL1 1.51 0 -2.28 0 MirTarget -0.65 8.0E-5 NA
33 hsa-miR-21-5p ATRX 1.51 0 -0.07 0.48759 miRNAWalker2 validate -0.1 0.00335 NA
34 hsa-miR-21-5p ATXN3 1.51 0 -0.29 0.00037 mirMAP -0.22 0 NA
35 hsa-miR-21-5p AUTS2 1.51 0 -1.2 0 miRNAWalker2 validate -0.85 0 NA
36 hsa-miR-21-5p BACE1 1.51 0 -0.45 0 mirMAP -0.29 0 NA
37 hsa-miR-21-5p BCL6 1.51 0 -0.38 0.00305 miRNAWalker2 validate -0.19 6.0E-5 NA
38 hsa-miR-21-5p BDH2 1.51 0 -1.59 0 miRNAWalker2 validate -0.57 0 NA
39 hsa-miR-21-5p BMP2K 1.51 0 -0.82 0 mirMAP -0.12 0.00963 NA
40 hsa-miR-21-5p BMPR2 1.51 0 -0.74 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.28 0 NA
41 hsa-miR-21-5p BRD1 1.51 0 -0.22 0.01173 MirTarget -0.1 0.0018 NA
42 hsa-miR-21-5p C16orf52 1.51 0 -0.5 0 miRNATAP -0.29 0 NA
43 hsa-miR-21-5p C1orf226 1.51 0 0.29 0.07217 mirMAP -0.13 0.03584 NA
44 hsa-miR-21-5p CADM2 1.51 0 -2.32 0 mirMAP; miRNATAP -0.38 0.00648 NA
45 hsa-miR-21-5p CALD1 1.51 0 -0.53 0 miRNAWalker2 validate; MirTarget -0.27 0 NA
46 hsa-miR-21-5p CASC4 1.51 0 -0.46 0 miRNATAP -0.14 8.0E-5 NA
47 hsa-miR-21-5p CCDC121 1.51 0 0.09 0.43018 MirTarget -0.21 0 NA
48 hsa-miR-21-5p CCDC152 1.51 0 -1.09 0 mirMAP -0.61 0 NA
49 hsa-miR-21-5p CCNG1 1.51 0 -0.05 0.64033 miRNAWalker2 validate -0.13 0.00024 NA
50 hsa-miR-21-5p CLCN5 1.51 0 -0.78 0 miRNAWalker2 validate; mirMAP -0.33 0 NA
51 hsa-miR-21-5p CLOCK 1.51 0 -0.53 0.00745 miRNAWalker2 validate -0.26 0.00029 NA
52 hsa-miR-21-5p CNTFR 1.51 0 -3.51 0 miRNATAP -1.1 0 NA
53 hsa-miR-21-5p COBLL1 1.51 0 -1.47 0 miRNAWalker2 validate -0.8 0 NA
54 hsa-miR-21-5p CPEB3 1.51 0 -2.74 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.98 0 NA
55 hsa-miR-21-5p CREBL2 1.51 0 -0.86 0 miRNATAP -0.28 0 NA
56 hsa-miR-21-5p CRIM1 1.51 0 -0.43 0.03963 miRNATAP -0.15 0.04655 NA
57 hsa-miR-21-5p CSNK1A1 1.51 0 -0.34 0 miRNAWalker2 validate -0.1 0 NA
58 hsa-miR-21-5p CYBRD1 1.51 0 -1.29 0 miRNAWalker2 validate -0.31 6.0E-5 NA
59 hsa-miR-21-5p CYP4V2 1.51 0 -1.71 0 miRNAWalker2 validate -0.71 0 NA
60 hsa-miR-21-5p DAAM1 1.51 0 -0.82 3.0E-5 miRNAWalker2 validate -0.58 0 NA
61 hsa-miR-21-5p DCAF10 1.51 0 -0.27 0.00016 miRNAWalker2 validate -0.19 0 NA
62 hsa-miR-21-5p DCAF8 1.51 0 -0.03 0.75166 miRNAWalker2 validate -0.16 0 NA
63 hsa-miR-21-5p DDAH1 1.51 0 -0.92 0 miRNAWalker2 validate -0.39 0 26741162 In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX
64 hsa-miR-21-5p DDR2 1.51 0 -0.84 0.00128 miRNAWalker2 validate -0.3 0.00149 NA
65 hsa-miR-21-5p DDX3X 1.51 0 -0.7 0 miRNAWalker2 validate -0.2 0 NA
66 hsa-miR-21-5p DLG1 1.51 0 -0.14 0.08412 miRNAWalker2 validate -0.19 0 NA
67 hsa-miR-21-5p DMD 1.51 0 -1.66 0 miRNAWalker2 validate -0.77 0 NA
68 hsa-miR-21-5p DOCK4 1.51 0 -0.2 0.07305 miRNAWalker2 validate; miRTarBase -0.11 0.00485 NA
69 hsa-miR-21-5p DOCK5 1.51 0 -0.64 0.00098 miRNAWalker2 validate; miRTarBase -0.25 0.00043 NA
70 hsa-miR-21-5p DOK6 1.51 0 -1.91 0 mirMAP -0.47 8.0E-5 NA
71 hsa-miR-21-5p DST 1.51 0 -0.38 0.00155 mirMAP -0.19 1.0E-5 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen
72 hsa-miR-21-5p DUSP10 1.51 0 -1.25 0 miRNAWalker2 validate; miRTarBase -0.34 0 NA
73 hsa-miR-21-5p EGFR 1.51 0 -1.02 0 miRNAWalker2 validate; miRTarBase -0.44 0 24198203; 20113523; 24012640; 24331411; 26563758; 19597153; 26026961; 20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status
74 hsa-miR-21-5p EIF1AX 1.51 0 -0.29 0.00114 miRNATAP -0.23 0 NA
75 hsa-miR-21-5p EIF4EBP2 1.51 0 -0.11 0.27493 miRNAWalker2 validate -0.25 0 NA
76 hsa-miR-21-5p EIF5 1.51 0 -0.72 0 miRNAWalker2 validate -0.26 0 NA
77 hsa-miR-21-5p ELF2 1.51 0 -0.39 0 MirTarget; miRNATAP -0.17 0 NA
78 hsa-miR-21-5p ENTPD4 1.51 0 -0.41 0.00079 mirMAP -0.14 0.00192 NA
79 hsa-miR-21-5p EPM2A 1.51 0 -1.16 0 miRNAWalker2 validate -0.56 0 NA
80 hsa-miR-21-5p EPM2AIP1 1.51 0 -0.3 0.00244 mirMAP -0.28 0 NA
81 hsa-miR-21-5p ESYT2 1.51 0 -0.17 0.03903 miRNAWalker2 validate; MirTarget -0.12 6.0E-5 NA
82 hsa-miR-21-5p EXOC5 1.51 0 -0.38 0 miRNAWalker2 validate -0.2 0 NA
83 hsa-miR-21-5p FAM107B 1.51 0 -0.78 0 miRNATAP -0.24 0 NA
84 hsa-miR-21-5p FAM126B 1.51 0 -0.64 0 miRNAWalker2 validate -0.28 0 NA
85 hsa-miR-21-5p FAM46A 1.51 0 -1.45 0 miRNAWalker2 validate; miRNATAP -0.31 0 NA
86 hsa-miR-21-5p FAM63B 1.51 0 -0.54 0.00241 miRNATAP -0.21 0.00123 NA
87 hsa-miR-21-5p FAS 1.51 0 -1.02 0 miRNAWalker2 validate -0.35 0 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7
88 hsa-miR-21-5p FBXL17 1.51 0 -0.25 0.00489 miRNAWalker2 validate; miRNATAP -0.19 0 NA
89 hsa-miR-21-5p FBXO28 1.51 0 -0.5 0 MirTarget -0.19 0 NA
90 hsa-miR-21-5p FBXO3 1.51 0 -0.54 0 miRNAWalker2 validate -0.27 0 NA
91 hsa-miR-21-5p FERMT2 1.51 0 -1.17 0 miRNAWalker2 validate -0.47 0 NA
92 hsa-miR-21-5p FGD4 1.51 0 -1.16 0 MirTarget -0.49 0 NA
93 hsa-miR-21-5p FGF2 1.51 0 -1.09 0.00032 mirMAP -0.44 6.0E-5 NA
94 hsa-miR-21-5p FILIP1L 1.51 0 -1.19 0 miRNAWalker2 validate -0.22 0.00092 NA
95 hsa-miR-21-5p FMR1 1.51 0 0.02 0.84822 miRNAWalker2 validate -0.18 0 NA
96 hsa-miR-21-5p FOXN3 1.51 0 -0.43 6.0E-5 miRNAWalker2 validate; mirMAP -0.36 0 NA
97 hsa-miR-21-5p FOXP2 1.51 0 -3.25 0 mirMAP -0.74 0 NA
98 hsa-miR-21-5p FREM2 1.51 0 -5.81 0 mirMAP -1.22 0 NA
99 hsa-miR-21-5p FRMD3 1.51 0 0.2 0.5219 MirTarget -0.38 0.00068 NA
100 hsa-miR-21-5p FZD4 1.51 0 -0.35 0.01097 mirMAP -0.32 0 NA
101 hsa-miR-21-5p GFOD1 1.51 0 -0.74 0 mirMAP -0.37 0 NA
102 hsa-miR-21-5p GLCCI1 1.51 0 -0.29 0.0401 miRNAWalker2 validate; MirTarget; miRNATAP -0.42 0 NA
103 hsa-miR-21-5p GLYR1 1.51 0 -0.17 0.02754 miRNATAP -0.1 0.00024 NA
104 hsa-miR-21-5p GNAQ 1.51 0 -0.39 1.0E-5 miRNAWalker2 validate -0.25 0 NA
105 hsa-miR-21-5p GNE 1.51 0 -1.82 0 miRNAWalker2 validate -0.76 0 NA
106 hsa-miR-21-5p GOLGA4 1.51 0 -0.24 0.01863 miRNAWalker2 validate -0.25 0 NA
107 hsa-miR-21-5p GPAM 1.51 0 -0.47 0.0638 miRNAWalker2 validate; mirMAP -0.63 0 NA
108 hsa-miR-21-5p GRAMD3 1.51 0 -0.64 0 MirTarget -0.27 0 NA
109 hsa-miR-21-5p GTF2A1 1.51 0 -0.69 0.00536 miRNAWalker2 validate -0.43 0 NA
110 hsa-miR-21-5p GTF2I 1.51 0 -0.01 0.96805 miRNAWalker2 validate -0.23 0.00076 NA
111 hsa-miR-21-5p GXYLT1 1.51 0 -0.35 3.0E-5 mirMAP -0.17 0 NA
112 hsa-miR-21-5p HBP1 1.51 0 -0.36 2.0E-5 miRNATAP -0.24 0 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53
113 hsa-miR-21-5p HECTD1 1.51 0 -0.51 0 miRNAWalker2 validate -0.38 0 NA
114 hsa-miR-21-5p HHIP 1.51 0 -5.86 0 mirMAP -1.12 0 NA
115 hsa-miR-21-5p HIPK1 1.51 0 -0.16 0.1272 mirMAP -0.11 0.00449 NA
116 hsa-miR-21-5p HIPK3 1.51 0 -1.5 0 MirTarget -0.58 0 NA
117 hsa-miR-21-5p HPS5 1.51 0 -1.54 0 miRNAWalker2 validate -0.36 0 NA
118 hsa-miR-21-5p HS3ST3B1 1.51 0 -2.61 0 miRNAWalker2 validate -0.98 0 NA
119 hsa-miR-21-5p HSD17B4 1.51 0 -0.64 1.0E-5 MirTarget -0.49 0 NA
120 hsa-miR-21-5p IDS 1.51 0 -0.55 0 mirMAP -0.1 0.01298 NA
121 hsa-miR-21-5p IL6R 1.51 0 -0.2 0.38255 MirTarget; miRNATAP -0.54 0 NA
122 hsa-miR-21-5p IL6ST 1.51 0 -1.92 0 mirMAP -0.64 0 NA
123 hsa-miR-21-5p ING3 1.51 0 -0.22 0.01365 MirTarget -0.18 0 NA
124 hsa-miR-21-5p INSR 1.51 0 -0.28 0.00786 mirMAP -0.13 0.00046 24804226; 27220494; 21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR
125 hsa-miR-21-5p INTS6 1.51 0 -0.65 0 MirTarget -0.23 0 NA
126 hsa-miR-21-5p IPP 1.51 0 -0.12 0.33175 miRNAWalker2 validate -0.15 0.00067 NA
127 hsa-miR-21-5p IREB2 1.51 0 -0.37 1.0E-5 miRNAWalker2 validate -0.22 0 NA
128 hsa-miR-21-5p ITGA1 1.51 0 -0.68 0 mirMAP -0.32 0 NA
129 hsa-miR-21-5p JMY 1.51 0 -0.07 0.48262 miRNAWalker2 validate; mirMAP -0.17 1.0E-5 NA
130 hsa-miR-21-5p KBTBD6 1.51 0 -0.19 0.03786 miRNAWalker2 validate; MirTarget -0.21 0 NA
131 hsa-miR-21-5p KBTBD7 1.51 0 -0.94 0 miRNAWalker2 validate -0.54 0 NA
132 hsa-miR-21-5p KCNA3 1.51 0 -1.97 0 miRNATAP -0.3 0.00296 NA
133 hsa-miR-21-5p KIAA0355 1.51 0 0.03 0.72841 MirTarget -0.15 0 NA
134 hsa-miR-21-5p KIAA1671 1.51 0 -0.84 0 mirMAP -0.16 0.00035 NA
135 hsa-miR-21-5p KLF12 1.51 0 -0.86 0 mirMAP -0.55 0 NA
136 hsa-miR-21-5p KLF3 1.51 0 -0.61 0 miRNATAP -0.23 0 NA
137 hsa-miR-21-5p KLF6 1.51 0 -1.44 0 miRNATAP -0.27 1.0E-5 NA
138 hsa-miR-21-5p KLF9 1.51 0 -1.36 0 miRNAWalker2 validate -0.61 0 NA
139 hsa-miR-21-5p KLHL15 1.51 0 -1.44 0 miRNAWalker2 validate; miRNATAP -0.66 0 NA
140 hsa-miR-21-5p KLHL24 1.51 0 -0.4 6.0E-5 miRNAWalker2 validate -0.3 0 NA
141 hsa-miR-21-5p KLHL4 1.51 0 -1.09 0 mirMAP -0.18 0.03456 NA
142 hsa-miR-21-5p LAMP2 1.51 0 -0.14 0.20334 miRNAWalker2 validate -0.14 0.00074 NA
143 hsa-miR-21-5p LATS1 1.51 0 -0.73 4.0E-5 miRNAWalker2 validate -0.26 7.0E-5 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment
144 hsa-miR-21-5p LCOR 1.51 0 -0.83 0.00038 mirMAP -0.3 0.00043 NA
145 hsa-miR-21-5p LCORL 1.51 0 -0.47 0.00013 miRNAWalker2 validate; miRNATAP -0.17 0.00014 NA
146 hsa-miR-21-5p LEMD3 1.51 0 -0.24 0.00152 miRNATAP -0.12 1.0E-5 NA
147 hsa-miR-21-5p LIFR 1.51 0 -3.55 0 miRNAWalker2 validate -0.97 0 NA
148 hsa-miR-21-5p LIN7C 1.51 0 -0.78 0 miRNAWalker2 validate -0.32 0 NA
149 hsa-miR-21-5p LMBR1 1.51 0 -0.13 0.15477 miRNAWalker2 validate -0.12 0.00014 NA
150 hsa-miR-21-5p LPA 1.51 0 -3.96 0 MirTarget -1.32 0 26098771 DNA microarray and real-time PCR analyses further demonstrated that LPA up-regulated the oncomiR miR-21 through an LPA1/Pi3K/ZEB1-dependent mechanism

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 65 1784 2.123e-08 9.879e-05
2 PROTEIN PHOSPHORYLATION 42 944 5.05e-08 0.0001175
3 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 18 229 1.707e-07 0.0002648
4 INTRACELLULAR SIGNAL TRANSDUCTION 56 1572 4.975e-07 0.0005787
5 PHOSPHORYLATION 46 1228 1.56e-06 0.001452
6 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 55 1656 5.379e-06 0.002276
7 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 59 1805 3.808e-06 0.002276
8 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 52 1517 4.143e-06 0.002276
9 POSITIVE REGULATION OF GENE EXPRESSION 57 1733 4.742e-06 0.002276
10 ENSHEATHMENT OF NEURONS 10 91 5.161e-06 0.002276
11 AXON ENSHEATHMENT 10 91 5.161e-06 0.002276
12 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 62 1977 7.794e-06 0.003011
13 TISSUE DEVELOPMENT 51 1518 9.058e-06 0.003011
14 NEGATIVE REGULATION OF CELL COMMUNICATION 43 1192 9.046e-06 0.003011
15 NEGATIVE REGULATION OF GENE EXPRESSION 50 1493 1.222e-05 0.003554
16 REGULATION OF CELL DIFFERENTIATION 50 1492 1.2e-05 0.003554
17 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 29 689 1.887e-05 0.005165
18 NEUROGENESIS 47 1402 2.24e-05 0.005485
19 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 46 1360 2.216e-05 0.005485
20 NEGATIVE REGULATION OF PHOSPHORYLATION 21 422 2.572e-05 0.005698
21 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 1004 2.534e-05 0.005698
22 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 53 1672 2.966e-05 0.006274
23 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 33 873 4.337e-05 0.008773
24 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 48 1492 5.123e-05 0.009931
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 63 1737 4.335e-08 2.014e-05
2 PROTEIN SERINE THREONINE KINASE ACTIVITY 27 445 3.572e-08 2.014e-05
3 PROTEIN KINASE ACTIVITY 32 640 1.725e-07 3.645e-05
4 KINASE ACTIVITY 38 842 1.61e-07 3.645e-05
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 42 992 1.962e-07 3.645e-05
6 TRANSLATION REPRESSOR ACTIVITY 6 20 9.731e-07 0.0001507
7 GROWTH FACTOR BINDING 12 123 2.119e-06 0.0002812
8 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 22 420 7.437e-06 0.0008636
9 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 9 81 1.4e-05 0.001301
10 KINASE BINDING 27 606 1.362e-05 0.001301
11 TRANSLATION REGULATOR ACTIVITY 6 35 3.251e-05 0.00255
12 PDZ DOMAIN BINDING 9 90 3.294e-05 0.00255
13 SMAD BINDING 8 72 4.217e-05 0.003014
14 RIBONUCLEOTIDE BINDING 56 1860 7.122e-05 0.004726
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX 34 703 1.53e-07 8.932e-05
2 PML BODY 11 97 1.27e-06 0.0003709
3 UBIQUITIN LIGASE COMPLEX 16 262 2.11e-05 0.003081
4 CULLIN RING UBIQUITIN LIGASE COMPLEX 12 150 1.652e-05 0.003081

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 11 132 2.537e-05 0.001066
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 11 139 4.099e-05 0.001066
3 MAPK_signaling_pathway_hsa04010 16 295 8.736e-05 0.001514
4 Cellular_senescence_hsa04218 11 160 0.000146 0.001788
5 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.000172 0.001788
6 HIF_1_signaling_pathway_hsa04066 7 100 0.002107 0.01826
7 Rap1_signaling_pathway_hsa04015 10 206 0.004033 0.02961
8 PI3K_Akt_signaling_pathway_hsa04151 14 352 0.004555 0.02961
9 Hippo_signaling_pathway_hsa04390 8 154 0.006535 0.03776
10 Jak_STAT_signaling_pathway_hsa04630 8 162 0.008761 0.04292
11 Ras_signaling_pathway_hsa04014 10 232 0.009079 0.04292
12 Regulation_of_actin_cytoskeleton_hsa04810 9 208 0.01268 0.05496
13 mTOR_signaling_pathway_hsa04150 7 151 0.01891 0.07161
14 Sphingolipid_signaling_pathway_hsa04071 6 118 0.01928 0.07161
15 Gap_junction_hsa04540 5 88 0.02069 0.07172
16 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.03231 0.1018
17 p53_signaling_pathway_hsa04115 4 68 0.03329 0.1018
18 Adherens_junction_hsa04520 4 72 0.03982 0.115
19 TNF_signaling_pathway_hsa04668 5 108 0.04435 0.117
20 ABC_transporters_hsa02010 3 45 0.04613 0.117
21 Wnt_signaling_pathway_hsa04310 6 146 0.04726 0.117
22 Hedgehog_signaling_pathway_hsa04340 3 47 0.05138 0.1214
23 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.05404 0.1222
24 TGF_beta_signaling_pathway_hsa04350 4 84 0.06347 0.1314
25 cAMP_signaling_pathway_hsa04024 7 198 0.06525 0.1314
26 ErbB_signaling_pathway_hsa04012 4 85 0.06571 0.1314
27 Tight_junction_hsa04530 6 170 0.08474 0.1632
28 VEGF_signaling_pathway_hsa04370 3 59 0.0884 0.1642
29 Apelin_signaling_pathway_hsa04371 5 137 0.09914 0.1778
30 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.1209 0.2096
31 Focal_adhesion_hsa04510 6 199 0.1466 0.2459
32 AMPK_signaling_pathway_hsa04152 4 121 0.1708 0.2776
33 Autophagy_animal_hsa04140 4 128 0.1958 0.3085
34 Calcium_signaling_pathway_hsa04020 5 182 0.2262 0.346
35 Lysosome_hsa04142 3 123 0.3767 0.5362
36 Cell_cycle_hsa04110 3 124 0.3816 0.5362
37 Oocyte_meiosis_hsa04114 3 124 0.3816 0.5362
38 Peroxisome_hsa04146 2 83 0.4378 0.5685
39 Endocytosis_hsa04144 5 244 0.4413 0.5685
40 Apoptosis_hsa04210 3 138 0.4482 0.5685
41 Phagosome_hsa04145 3 152 0.5118 0.6214
42 Necroptosis_hsa04217 3 164 0.5631 0.6655

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-119D9.1 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-181b-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-25-3p;hsa-miR-425-5p;hsa-miR-93-5p 10 PTEN Sponge network -2.765 0 -0.546 0 0.375
2 LDLRAD4-AS1 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-181b-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-25-3p;hsa-miR-589-3p;hsa-miR-93-5p 10 PTEN Sponge network -3.366 0 -0.546 0 0.292
3 RP11-166D19.1 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-193a-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-425-5p;hsa-miR-484;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p 14 PTEN Sponge network -0.244 0.28835 -0.546 0 0.28
4 LINC01018 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-181b-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-25-3p;hsa-miR-589-3p;hsa-miR-93-5p 10 PTEN Sponge network -3.231 0 -0.546 0 0.256

Quest ID: c691256d4d5ae51e5987e054489b6187