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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-16-5p AADAT 0.47 0.02635 -0.43 0.07498 miRNAWalker2 validate -0.28 6.0E-5 NA
2 hsa-miR-16-5p ABCB5 0.47 0.02635 -0.96 0.04077 MirTarget -1.06 0 NA
3 hsa-miR-16-5p ABCC1 0.47 0.02635 0.34 0.00384 miRNAWalker2 validate -0.1 0.0029 NA
4 hsa-miR-16-5p ABL1 0.47 0.02635 -0.21 0.07804 mirMAP -0.25 0 NA
5 hsa-miR-16-5p ABL2 0.47 0.02635 0.82 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.13 3.0E-5 NA
6 hsa-miR-16-5p ABTB2 0.47 0.02635 0.16 0.33586 MirTarget -0.13 0.00519 NA
7 hsa-miR-16-5p ACSBG1 0.47 0.02635 -0.89 4.0E-5 MirTarget -0.57 0 NA
8 hsa-miR-16-5p ACTB 0.47 0.02635 -0.25 0.01736 miRNAWalker2 validate -0.16 0 NA
9 hsa-miR-16-5p ACTN1 0.47 0.02635 0.14 0.44606 miRNAWalker2 validate -0.5 0 NA
10 hsa-miR-16-5p ACVR2A 0.47 0.02635 -0.41 0.00039 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.2 0 NA
11 hsa-miR-16-5p ACVR2B 0.47 0.02635 0.48 0.00365 miRNATAP -0.12 0.01367 NA
12 hsa-miR-16-5p ADAMTS18 0.47 0.02635 3.26 0 miRNATAP -0.24 0.03133 NA
13 hsa-miR-16-5p ADAMTS3 0.47 0.02635 0.38 0.04723 miRNATAP -0.31 0 NA
14 hsa-miR-16-5p ADAMTS5 0.47 0.02635 0.19 0.27716 miRNATAP -0.28 0 NA
15 hsa-miR-16-5p ADAMTSL3 0.47 0.02635 -1.56 0 MirTarget -0.86 0 NA
16 hsa-miR-16-5p ADCY2 0.47 0.02635 -1.53 4.0E-5 mirMAP -1.03 0 NA
17 hsa-miR-16-5p ADCY5 0.47 0.02635 -1.84 1.0E-5 MirTarget; miRNATAP -1.19 0 NA
18 hsa-miR-16-5p ADRB2 0.47 0.02635 -2.78 0 MirTarget -0.45 0 NA
19 hsa-miR-16-5p AFF4 0.47 0.02635 -0.27 0.01565 MirTarget; miRNATAP -0.21 0 NA
20 hsa-miR-16-5p AGPAT4 0.47 0.02635 0.09 0.61321 mirMAP -0.4 0 NA
21 hsa-miR-16-5p AHNAK2 0.47 0.02635 -0.59 0.13882 miRNAWalker2 validate -1.14 0 NA
22 hsa-miR-16-5p AK4 0.47 0.02635 -1.12 0.00017 MirTarget; miRNATAP -0.47 0 NA
23 hsa-miR-16-5p AKAP11 0.47 0.02635 0.2 0.09825 MirTarget; miRNATAP -0.19 0 NA
24 hsa-miR-16-5p AKT3 0.47 0.02635 -0.27 0.18865 miRNAWalker2 validate; miRTarBase; miRNATAP -0.57 0 NA
25 hsa-miR-16-5p AMOTL1 0.47 0.02635 -0.49 0.0546 MirTarget; miRNATAP -0.66 0 NA
26 hsa-miR-16-5p ANAPC16 0.47 0.02635 -0.56 0 miRNAWalker2 validate -0.13 1.0E-5 NA
27 hsa-miR-16-5p ANK2 0.47 0.02635 -1.6 1.0E-5 MirTarget; miRNATAP -1.03 0 NA
28 hsa-miR-16-5p ANKRD29 0.47 0.02635 -1.35 1.0E-5 MirTarget -0.51 0 NA
29 hsa-miR-16-5p ANKS1A 0.47 0.02635 -0.13 0.22949 MirTarget -0.26 0 NA
30 hsa-miR-16-5p ANO3 0.47 0.02635 -0.68 0.15551 MirTarget; miRNATAP -0.28 0.04553 NA
31 hsa-miR-16-5p AR 0.47 0.02635 -1.55 0 mirMAP; miRNATAP -0.99 0 NA
32 hsa-miR-16-5p ARHGAP20 0.47 0.02635 -1.38 0 MirTarget; miRNATAP -0.75 0 NA
33 hsa-miR-16-5p ARHGAP5 0.47 0.02635 -0.12 0.26304 MirTarget; miRNATAP -0.21 0 NA
34 hsa-miR-16-5p ARHGEF12 0.47 0.02635 0.09 0.35693 MirTarget -0.17 0 NA
35 hsa-miR-16-5p ARHGEF9 0.47 0.02635 -0.63 0 miRNATAP -0.23 0 NA
36 hsa-miR-16-5p ARIH1 0.47 0.02635 0.02 0.79347 MirTarget -0.12 0 NA
37 hsa-miR-16-5p ARL10 0.47 0.02635 -0.28 0.19832 miRNAWalker2 validate -0.49 0 NA
38 hsa-miR-16-5p ARL3 0.47 0.02635 -0.52 0 miRNAWalker2 validate; MirTarget -0.12 7.0E-5 NA
39 hsa-miR-16-5p ARL8B 0.47 0.02635 -0.21 0.01117 MirTarget; miRNATAP -0.16 0 NA
40 hsa-miR-16-5p ARMCX2 0.47 0.02635 -0.77 0.00112 miRNAWalker2 validate; MirTarget; miRNATAP -0.53 0 NA
41 hsa-miR-16-5p ARNT2 0.47 0.02635 -0.33 0.25851 mirMAP -0.26 0.00249 NA
42 hsa-miR-16-5p ARVCF 0.47 0.02635 0.32 0.05547 mirMAP -0.27 0 NA
43 hsa-miR-16-5p ASB1 0.47 0.02635 -0.28 0.00868 MirTarget -0.21 0 NA
44 hsa-miR-16-5p ASH1L 0.47 0.02635 0.11 0.30048 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0 NA
45 hsa-miR-16-5p ASTN1 0.47 0.02635 -2.39 2.0E-5 MirTarget -1.23 0 NA
46 hsa-miR-16-5p ATF7 0.47 0.02635 0.07 0.43806 miRNAWalker2 validate -0.22 0 NA
47 hsa-miR-16-5p ATG14 0.47 0.02635 0 0.96836 miRNAWalker2 validate; MirTarget; miRNATAP -0.27 0 NA
48 hsa-miR-16-5p ATL2 0.47 0.02635 -0.38 0.00058 miRNAWalker2 validate -0.25 0 NA
49 hsa-miR-16-5p ATP2B2 0.47 0.02635 -1.89 0 MirTarget; miRNATAP -0.94 0 NA
50 hsa-miR-16-5p ATP7A 0.47 0.02635 -0.24 0.02606 MirTarget -0.12 5.0E-5 NA
51 hsa-miR-16-5p ATP8A2 0.47 0.02635 -1.33 1.0E-5 miRNAWalker2 validate -0.31 0.0004 NA
52 hsa-miR-16-5p ATXN1L 0.47 0.02635 -0.07 0.43241 miRNATAP -0.14 0 NA
53 hsa-miR-16-5p ATXN2 0.47 0.02635 0.27 0.00072 MirTarget; miRNATAP -0.14 0 NA
54 hsa-miR-16-5p ATXN7L1 0.47 0.02635 0.06 0.53653 miRNATAP -0.15 0 NA
55 hsa-miR-16-5p BACE1 0.47 0.02635 -0.1 0.49755 miRNATAP -0.36 0 NA
56 hsa-miR-16-5p BACH2 0.47 0.02635 -0.15 0.55909 MirTarget; miRNATAP -0.34 1.0E-5 NA
57 hsa-miR-16-5p BCAP29 0.47 0.02635 -0.09 0.29187 MirTarget -0.17 0 NA
58 hsa-miR-16-5p BCL2 0.47 0.02635 -0.9 0 miRNAWalker2 validate; miRTarBase -0.31 0 18449891; 21336967; 24447552; 25435430; 24598659; 18931683; 22966344; 25623762 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells
59 hsa-miR-16-5p BHLHE41 0.47 0.02635 0.35 0.12753 miRNATAP -0.34 0 NA
60 hsa-miR-16-5p BMX 0.47 0.02635 -1.36 0 MirTarget; miRNATAP -0.41 0 NA
61 hsa-miR-16-5p BNC2 0.47 0.02635 -0.49 0.09988 miRNAWalker2 validate -0.9 0 NA
62 hsa-miR-16-5p BRD3 0.47 0.02635 0.37 0.00013 mirMAP -0.15 0 NA
63 hsa-miR-16-5p BRSK2 0.47 0.02635 0.55 0.14019 mirMAP -0.45 3.0E-5 NA
64 hsa-miR-16-5p BTBD19 0.47 0.02635 0.96 0 mirMAP -0.37 0 NA
65 hsa-miR-16-5p BTG2 0.47 0.02635 -1.76 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.27 3.0E-5 NA
66 hsa-miR-16-5p BTRC 0.47 0.02635 -0.03 0.74173 miRNAWalker2 validate; MirTarget; miRNATAP -0.13 0 NA
67 hsa-miR-16-5p BVES 0.47 0.02635 -1.51 1.0E-5 MirTarget -1.02 0 NA
68 hsa-miR-16-5p C15orf52 0.47 0.02635 -0.77 0.00649 mirMAP -0.85 0 NA
69 hsa-miR-16-5p C16orf52 0.47 0.02635 -0.07 0.3851 miRNATAP -0.18 0 NA
70 hsa-miR-16-5p C1orf21 0.47 0.02635 -0.73 9.0E-5 mirMAP; miRNATAP -0.38 0 NA
71 hsa-miR-16-5p CACNA1E 0.47 0.02635 1.75 0 MirTarget -0.23 0.03849 NA
72 hsa-miR-16-5p CACNA2D1 0.47 0.02635 -0.85 0.00675 miRNAWalker2 validate -0.8 0 NA
73 hsa-miR-16-5p CACNB2 0.47 0.02635 -1.06 0.00045 miRNAWalker2 validate -0.95 0 NA
74 hsa-miR-16-5p CACNB4 0.47 0.02635 -1.06 0.0002 miRNATAP -0.57 0 NA
75 hsa-miR-16-5p CADM1 0.47 0.02635 -0.9 0.00084 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 5.0E-5 NA
76 hsa-miR-16-5p CALM1 0.47 0.02635 -0.78 0 miRNATAP -0.17 0 NA
77 hsa-miR-16-5p CALU 0.47 0.02635 0.67 0 miRNAWalker2 validate; MirTarget -0.11 0.0011 NA
78 hsa-miR-16-5p CAMK2G 0.47 0.02635 -0.53 0.00041 miRNAWalker2 validate -0.44 0 NA
79 hsa-miR-16-5p CAMKV 0.47 0.02635 0.37 0.43837 miRNAWalker2 validate; miRNATAP -0.29 0.03624 NA
80 hsa-miR-16-5p CAMSAP1 0.47 0.02635 0.24 0.03991 miRNAWalker2 validate; MirTarget; miRNATAP -0.1 0.00344 NA
81 hsa-miR-16-5p CAMSAP2 0.47 0.02635 0.42 0.00053 miRNATAP -0.29 0 NA
82 hsa-miR-16-5p CAPN6 0.47 0.02635 -1.29 0.02537 miRNATAP -0.64 0.00013 NA
83 hsa-miR-16-5p CAPZA2 0.47 0.02635 -0.19 0.08777 miRNAWalker2 validate; MirTarget -0.16 0 NA
84 hsa-miR-16-5p CASZ1 0.47 0.02635 -0.74 0 MirTarget -0.17 8.0E-5 NA
85 hsa-miR-16-5p CBFA2T3 0.47 0.02635 -1.22 1.0E-5 MirTarget; miRNATAP -0.26 0.00132 NA
86 hsa-miR-16-5p CBL 0.47 0.02635 0.29 0.01267 mirMAP -0.13 8.0E-5 NA
87 hsa-miR-16-5p CBX5 0.47 0.02635 0.16 0.24446 miRNATAP -0.11 0.00638 NA
88 hsa-miR-16-5p CCDC144A 0.47 0.02635 -0.22 0.66837 mirMAP -0.48 0.00167 NA
89 hsa-miR-16-5p CCDC149 0.47 0.02635 -0.52 0.00236 MirTarget -0.25 0 NA
90 hsa-miR-16-5p CCDC6 0.47 0.02635 0.27 0.02555 MirTarget; miRNATAP -0.16 0 NA
91 hsa-miR-16-5p CCND2 0.47 0.02635 -0.27 0.3112 miRNAWalker2 validate; miRNATAP -0.52 0 NA
92 hsa-miR-16-5p CCPG1 0.47 0.02635 -0.21 0.04535 miRNAWalker2 validate -0.13 1.0E-5 NA
93 hsa-miR-16-5p CD44 0.47 0.02635 0.22 0.30295 miRNAWalker2 validate -0.18 0.00451 NA
94 hsa-miR-16-5p CDADC1 0.47 0.02635 -0.18 0.09805 miRNAWalker2 validate -0.12 9.0E-5 NA
95 hsa-miR-16-5p CDC37L1 0.47 0.02635 -0.43 9.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0 NA
96 hsa-miR-16-5p CDK17 0.47 0.02635 0.07 0.48708 miRNAWalker2 validate; MirTarget; miRNATAP -0.23 0 NA
97 hsa-miR-16-5p CDS2 0.47 0.02635 -0.26 0.01248 miRNAWalker2 validate; mirMAP; miRNATAP -0.24 0 NA
98 hsa-miR-16-5p CEP63 0.47 0.02635 -0.1 0.21895 miRNAWalker2 validate -0.14 0 NA
99 hsa-miR-16-5p CFL2 0.47 0.02635 -1.3 0 miRNAWalker2 validate -0.83 0 NA
100 hsa-miR-16-5p CHD3 0.47 0.02635 -0 0.99669 miRNAWalker2 validate -0.16 4.0E-5 NA
101 hsa-miR-16-5p CHD5 0.47 0.02635 -0.92 0.01521 miRNATAP -0.94 0 NA
102 hsa-miR-16-5p CHD9 0.47 0.02635 -0.26 0.02092 miRNATAP -0.26 0 NA
103 hsa-miR-16-5p CLASP1 0.47 0.02635 0.09 0.35045 miRNAWalker2 validate -0.2 0 NA
104 hsa-miR-16-5p CLOCK 0.47 0.02635 -0.1 0.34735 MirTarget -0.13 2.0E-5 NA
105 hsa-miR-16-5p CNKSR2 0.47 0.02635 -1.85 0.00014 miRNATAP -1.33 0 NA
106 hsa-miR-16-5p CNN1 0.47 0.02635 -2.63 0 miRNATAP -1.53 0 NA
107 hsa-miR-16-5p CNN3 0.47 0.02635 -0.56 0.00032 miRNAWalker2 validate -0.27 0 NA
108 hsa-miR-16-5p CNTNAP1 0.47 0.02635 0.36 0.13727 MirTarget -0.6 0 NA
109 hsa-miR-16-5p COL12A1 0.47 0.02635 1.85 0 MirTarget; miRNATAP -0.32 1.0E-5 NA
110 hsa-miR-16-5p COL24A1 0.47 0.02635 0.06 0.83086 MirTarget; miRNATAP -0.59 0 NA
111 hsa-miR-16-5p COL4A1 0.47 0.02635 1.79 0 miRNAWalker2 validate -0.15 0.01216 NA
112 hsa-miR-16-5p COL4A2 0.47 0.02635 1.02 0 miRNAWalker2 validate -0.28 0 NA
113 hsa-miR-16-5p COL4A3BP 0.47 0.02635 -0.44 0 MirTarget; miRNATAP -0.16 0 NA
114 hsa-miR-16-5p COL4A4 0.47 0.02635 0.2 0.56272 mirMAP -0.44 1.0E-5 NA
115 hsa-miR-16-5p COLQ 0.47 0.02635 -0.03 0.88881 MirTarget -0.39 0 NA
116 hsa-miR-16-5p COPS2 0.47 0.02635 -0.18 0.04974 MirTarget -0.13 0 NA
117 hsa-miR-16-5p CPEB2 0.47 0.02635 -0.81 0 miRNATAP -0.29 0 NA
118 hsa-miR-16-5p CPEB3 0.47 0.02635 -0.73 0 MirTarget; miRNATAP -0.19 0 NA
119 hsa-miR-16-5p CPNE8 0.47 0.02635 0.01 0.9743 miRNAWalker2 validate -0.38 0 NA
120 hsa-miR-16-5p CREB3L2 0.47 0.02635 -0.53 2.0E-5 miRNAWalker2 validate -0.18 0 NA
121 hsa-miR-16-5p CREB5 0.47 0.02635 0.01 0.953 miRNATAP -0.43 0 NA
122 hsa-miR-16-5p CREBL2 0.47 0.02635 -0.29 0.00289 miRNAWalker2 validate -0.14 0 NA
123 hsa-miR-16-5p CREBRF 0.47 0.02635 -0.37 0.00727 MirTarget; miRNATAP -0.41 0 NA
124 hsa-miR-16-5p CRHBP 0.47 0.02635 -1.87 0 miRNAWalker2 validate -0.5 0 NA
125 hsa-miR-16-5p CRIM1 0.47 0.02635 0.2 0.18944 MirTarget; miRNATAP -0.31 0 NA
126 hsa-miR-16-5p CRTC3 0.47 0.02635 0.16 0.16786 miRNATAP -0.23 0 NA
127 hsa-miR-16-5p CSDE1 0.47 0.02635 -0.49 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0 NA
128 hsa-miR-16-5p CSGALNACT1 0.47 0.02635 0.02 0.92021 miRNAWalker2 validate -0.19 2.0E-5 NA
129 hsa-miR-16-5p CSRNP1 0.47 0.02635 -1.45 0 MirTarget -0.17 0.00117 NA
130 hsa-miR-16-5p CSRNP2 0.47 0.02635 0.24 0.00293 miRNATAP -0.11 0 NA
131 hsa-miR-16-5p CTDSPL 0.47 0.02635 0.08 0.45121 miRNATAP -0.18 0 NA
132 hsa-miR-16-5p CYS1 0.47 0.02635 -1.28 0.00036 mirMAP -0.94 0 NA
133 hsa-miR-16-5p DCAF5 0.47 0.02635 -0.43 0 MirTarget; miRNATAP -0.14 0 NA
134 hsa-miR-16-5p DCLK1 0.47 0.02635 -1.32 0.00014 miRNATAP -0.84 0 NA
135 hsa-miR-16-5p DCUN1D4 0.47 0.02635 -0.26 0.02159 MirTarget; miRNATAP -0.23 0 NA
136 hsa-miR-16-5p DCX 0.47 0.02635 -0.84 0.10669 mirMAP -0.99 0 NA
137 hsa-miR-16-5p DDHD2 0.47 0.02635 -0.15 0.19384 miRNAWalker2 validate -0.21 0 NA
138 hsa-miR-16-5p DDX3Y 0.47 0.02635 -1.08 0.26927 miRNAWalker2 validate; MirTarget; miRNATAP -0.67 0.01858 NA
139 hsa-miR-16-5p DDX6 0.47 0.02635 0.09 0.36428 miRNAWalker2 validate -0.21 0 NA
140 hsa-miR-16-5p DENND4A 0.47 0.02635 0.06 0.54641 MirTarget -0.15 0 NA
141 hsa-miR-16-5p DEPTOR 0.47 0.02635 -0.64 0.00063 MirTarget -0.12 0.03198 NA
142 hsa-miR-16-5p DICER1 0.47 0.02635 0.04 0.674 miRNAWalker2 validate -0.11 0.00017 NA
143 hsa-miR-16-5p DIXDC1 0.47 0.02635 -1.16 0 miRNAWalker2 validate; MirTarget -0.8 0 NA
144 hsa-miR-16-5p DLC1 0.47 0.02635 -0.38 0.05038 miRNAWalker2 validate -0.47 0 NA
145 hsa-miR-16-5p DLL1 0.47 0.02635 -0.37 0.03112 miRNATAP -0.14 0.00452 NA
146 hsa-miR-16-5p DMD 0.47 0.02635 -1.51 0 miRNAWalker2 validate -0.99 0 NA
147 hsa-miR-16-5p DMTF1 0.47 0.02635 0.25 0.02726 miRNAWalker2 validate; MirTarget; miRNATAP -0.12 0.00016 NA
148 hsa-miR-16-5p DNAJA4 0.47 0.02635 0.27 0.13216 miRNAWalker2 validate -0.12 0.0268 NA
149 hsa-miR-16-5p DNAJB4 0.47 0.02635 -0.7 1.0E-5 miRNAWalker2 validate -0.45 0 NA
150 hsa-miR-16-5p DOCK4 0.47 0.02635 0.5 0.00108 MirTarget -0.21 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 107 1402 1.628e-16 7.573e-13
2 NEURON DIFFERENTIATION 73 874 2.382e-13 5.543e-10
3 CELLULAR COMPONENT MORPHOGENESIS 73 900 1.005e-12 1.559e-09
4 CENTRAL NERVOUS SYSTEM DEVELOPMENT 71 872 1.768e-12 2.056e-09
5 CELL DEVELOPMENT 97 1426 5.446e-12 5.068e-09
6 HEAD DEVELOPMENT 61 709 7.496e-12 5.813e-09
7 NEURON DEVELOPMENT 59 687 1.82e-11 1.21e-08
8 INTRACELLULAR SIGNAL TRANSDUCTION 102 1572 2.302e-11 1.339e-08
9 REGULATION OF DEVELOPMENTAL GROWTH 35 289 3.244e-11 1.677e-08
10 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 72 957 4.915e-11 2.287e-08
11 NEURON PROJECTION DEVELOPMENT 50 545 6.796e-11 2.474e-08
12 REGULATION OF CELL DIFFERENTIATION 97 1492 6.955e-11 2.474e-08
13 CARDIOVASCULAR SYSTEM DEVELOPMENT 63 788 7.444e-11 2.474e-08
14 CIRCULATORY SYSTEM DEVELOPMENT 63 788 7.444e-11 2.474e-08
15 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 104 1672 1.644e-10 4.781e-08
16 CELL PROJECTION ORGANIZATION 68 902 1.628e-10 4.781e-08
17 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 47 513 2.712e-10 7.422e-08
18 TISSUE DEVELOPMENT 96 1518 3.926e-10 1.015e-07
19 PROTEIN PHOSPHORYLATION 69 944 4.48e-10 1.097e-07
20 REGULATION OF NEURON DIFFERENTIATION 48 554 1.133e-09 2.635e-07
21 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 58 750 1.548e-09 3.43e-07
22 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 77 1142 1.646e-09 3.482e-07
23 ORGAN MORPHOGENESIS 61 841 6.602e-09 1.336e-06
24 REGULATION OF NEURON PROJECTION DEVELOPMENT 38 408 9.292e-09 1.802e-06
25 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 102 1784 2.273e-08 4.23e-06
26 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 52 689 2.534e-08 4.535e-06
27 VASCULATURE DEVELOPMENT 40 469 4.396e-08 7.306e-06
28 POSITIVE REGULATION OF CELL DIFFERENTIATION 58 823 4.365e-08 7.306e-06
29 EMBRYO DEVELOPMENT 61 894 6.127e-08 9.83e-06
30 REGULATION OF ION TRANSPORT 46 592 7.111e-08 1.103e-05
31 REGULATION OF GROWTH 48 633 7.717e-08 1.122e-05
32 REGULATION OF CELL DEVELOPMENT 58 836 7.491e-08 1.122e-05
33 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 108 1977 8.805e-08 1.241e-05
34 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 94 1656 1.241e-07 1.699e-05
35 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 65 1008 1.773e-07 2.357e-05
36 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 43 554 1.977e-07 2.42e-05
37 CELL PART MORPHOGENESIS 47 633 1.966e-07 2.42e-05
38 REGULATION OF EXTENT OF CELL GROWTH 16 101 1.909e-07 2.42e-05
39 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 20 156 2.167e-07 2.586e-05
40 HEART DEVELOPMENT 38 466 3.015e-07 3.507e-05
41 REGULATION OF METAL ION TRANSPORT 30 325 4.137e-07 4.695e-05
42 REGULATION OF CELL MORPHOGENESIS 42 552 4.677e-07 5.181e-05
43 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 64 1021 5.977e-07 6.468e-05
44 REGULATION OF CELL PROJECTION ORGANIZATION 42 558 6.222e-07 6.58e-05
45 PHOSPHORYLATION 73 1228 6.935e-07 7.17e-05
46 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 75 1275 7.191e-07 7.273e-05
47 FOREBRAIN DEVELOPMENT 31 357 1e-06 9.597e-05
48 SECRETION 43 588 9.847e-07 9.597e-05
49 CEREBRAL CORTEX CELL MIGRATION 10 43 1.011e-06 9.597e-05
50 TISSUE MORPHOGENESIS 40 533 1.244e-06 0.0001157
51 MORPHOGENESIS OF AN EPITHELIUM 33 400 1.409e-06 0.0001286
52 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 38 498 1.544e-06 0.0001382
53 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 31 368 1.9e-06 0.0001668
54 HEART MORPHOGENESIS 22 212 2.15e-06 0.0001852
55 SECRETION BY CELL 37 486 2.236e-06 0.0001892
56 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 23 232 2.783e-06 0.0002312
57 REGULATION OF TRANSPORT 95 1804 2.954e-06 0.0002411
58 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 34 437 3.596e-06 0.0002752
59 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 13 84 3.493e-06 0.0002752
60 RESPONSE TO ENDOGENOUS STIMULUS 80 1450 3.607e-06 0.0002752
61 BEHAVIOR 38 516 3.586e-06 0.0002752
62 REGULATION OF MEMBRANE POTENTIAL 29 343 3.78e-06 0.0002837
63 EPITHELIUM DEVELOPMENT 58 945 3.982e-06 0.0002941
64 MEMBRANE DEPOLARIZATION 11 61 4.269e-06 0.0003047
65 REGULATION OF CELL SIZE 19 172 4.215e-06 0.0003047
66 NEURON PROJECTION MORPHOGENESIS 32 402 4.322e-06 0.0003047
67 HINDBRAIN MORPHOGENESIS 9 40 4.746e-06 0.0003296
68 FOREBRAIN CELL MIGRATION 11 62 5.037e-06 0.0003447
69 REGULATION OF TRANSMEMBRANE TRANSPORT 33 426 5.476e-06 0.0003693
70 REGULATION OF BLOOD CIRCULATION 26 295 5.668e-06 0.0003767
71 REGULATION OF CALCIUM ION TRANSPORT 21 209 6.065e-06 0.0003975
72 INNERVATION 7 23 6.317e-06 0.0004082
73 REGULATION OF PHOSPHORUS METABOLIC PROCESS 86 1618 6.502e-06 0.0004144
74 TUBE DEVELOPMENT 39 552 7.124e-06 0.0004479
75 MUSCLE STRUCTURE DEVELOPMENT 33 432 7.346e-06 0.0004558
76 REGULATION OF ANATOMICAL STRUCTURE SIZE 35 472 7.478e-06 0.0004578
77 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 28 337 7.699e-06 0.0004652
78 SKELETAL SYSTEM DEVELOPMENT 34 455 8.566e-06 0.000511
79 CEREBRAL CORTEX DEVELOPMENT 14 105 8.942e-06 0.0005267
80 REGULATION OF TRANSPORTER ACTIVITY 20 198 9.283e-06 0.0005399
81 POSITIVE REGULATION OF NEURON DIFFERENTIATION 26 306 1.09e-05 0.0006263
82 HINDBRAIN DEVELOPMENT 16 137 1.179e-05 0.0006454
83 NEGATIVE REGULATION OF PHOSPHORYLATION 32 422 1.17e-05 0.0006454
84 CELLULAR MACROMOLECULE LOCALIZATION 69 1234 1.154e-05 0.0006454
85 REGULATION OF AXONOGENESIS 18 168 1.148e-05 0.0006454
86 PALLIUM DEVELOPMENT 17 153 1.237e-05 0.0006692
87 NERVE DEVELOPMENT 11 68 1.27e-05 0.0006794
88 PEPTIDYL TYROSINE MODIFICATION 19 186 1.316e-05 0.0006878
89 MULTICELLULAR ORGANISMAL SIGNALING 15 123 1.302e-05 0.0006878
90 PLASMA MEMBRANE ORGANIZATION 20 203 1.345e-05 0.0006918
91 ENDOMEMBRANE SYSTEM ORGANIZATION 34 465 1.353e-05 0.0006918
92 REGULATION OF HEART CONTRACTION 21 221 1.436e-05 0.0006965
93 POSITIVE REGULATION OF GROWTH 22 238 1.398e-05 0.0006965
94 REGULATION OF SYSTEM PROCESS 36 507 1.437e-05 0.0006965
95 BIOLOGICAL ADHESION 60 1032 1.422e-05 0.0006965
96 INOSITOL LIPID MEDIATED SIGNALING 15 124 1.437e-05 0.0006965
97 POSITIVE REGULATION OF CELL COMMUNICATION 81 1532 1.504e-05 0.0007216
98 CELL CELL SIGNALING 48 767 1.688e-05 0.0008012
99 REGULATION OF PROTEIN MODIFICATION PROCESS 88 1710 1.739e-05 0.0008172
100 SEMAPHORIN PLEXIN SIGNALING PATHWAY 8 36 1.78e-05 0.000828
101 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 19 191 1.918e-05 0.0008798
102 REGULATION OF CELLULAR COMPONENT MOVEMENT 48 771 1.929e-05 0.0008798
103 RESPONSE TO GROWTH FACTOR 34 475 2.101e-05 0.0009493
104 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 16 144 2.215e-05 0.0009909
105 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 32 437 2.346e-05 0.00104
106 METENCEPHALON DEVELOPMENT 13 100 2.45e-05 0.001069
107 NEGATIVE REGULATION OF CELL COMMUNICATION 66 1192 2.458e-05 0.001069
108 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 49 801 2.487e-05 0.001071
109 NEGATIVE REGULATION OF AXON EXTENSION 8 38 2.714e-05 0.001127
110 POSITIVE REGULATION OF LOCOMOTION 31 420 2.695e-05 0.001127
111 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 8 38 2.714e-05 0.001127
112 PROTEIN LOCALIZATION 91 1805 2.696e-05 0.001127
113 TUBE MORPHOGENESIS 26 323 2.792e-05 0.00115
114 CELL SUBSTRATE ADHESION 17 164 3.07e-05 0.001253
115 MUSCLE CONTRACTION 21 233 3.178e-05 0.001275
116 BLOOD VESSEL MORPHOGENESIS 28 364 3.158e-05 0.001275
117 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 74 1395 3.259e-05 0.001296
118 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 3.316e-05 0.001297
119 REGULATION OF AXON GUIDANCE 8 39 3.316e-05 0.001297
120 REGULATION OF CELL PROLIFERATION 78 1496 3.541e-05 0.001373
121 CYTOSKELETON ORGANIZATION 50 838 3.915e-05 0.001505
122 IN UTERO EMBRYONIC DEVELOPMENT 25 311 4.051e-05 0.001545
123 ACTIN FILAMENT BASED PROCESS 32 450 4.148e-05 0.001569
124 SENSORY ORGAN DEVELOPMENT 34 493 4.459e-05 0.001673
125 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 57 1004 4.559e-05 0.001697
126 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 36 541 5.625e-05 0.002061
127 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 36 541 5.625e-05 0.002061
128 REGULATION OF CELLULAR COMPONENT SIZE 26 337 5.71e-05 0.002076
129 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 5.98e-05 0.002137
130 ACTION POTENTIAL 12 94 5.994e-05 0.002137
131 PROTEIN DEPHOSPHORYLATION 18 190 6.017e-05 0.002137
132 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 19 208 6.23e-05 0.002196
133 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 60 1087 6.371e-05 0.002229
134 MUSCLE SYSTEM PROCESS 23 282 6.531e-05 0.002268
135 NEURON MIGRATION 13 110 6.765e-05 0.002332
136 LOCOMOTION 61 1114 6.931e-05 0.002371
137 REGULATION OF BODY FLUID LEVELS 34 506 7.447e-05 0.002529
138 EXTRACELLULAR STRUCTURE ORGANIZATION 24 304 7.625e-05 0.002571
139 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 71 1360 7.826e-05 0.00262
140 SINGLE ORGANISM BEHAVIOR 28 384 8.061e-05 0.002679
141 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 9 56 8.22e-05 0.002693
142 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 39 616 8.167e-05 0.002693
143 REGULATION OF HOMEOSTATIC PROCESS 31 447 8.654e-05 0.002816
144 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 55 983 9.117e-05 0.002946
145 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 10 70 9.396e-05 0.003015
146 CYCLIC NUCLEOTIDE METABOLIC PROCESS 9 57 9.479e-05 0.003021
147 FOREBRAIN NEURON DEVELOPMENT 7 34 0.0001011 0.003179
148 CAMP METABOLIC PROCESS 7 34 0.0001011 0.003179
149 REGULATION OF CELL GROWTH 28 391 0.0001097 0.003426
150 ESTABLISHMENT OF LOCALIZATION IN CELL 83 1676 0.0001157 0.003563
151 EMBRYONIC MORPHOGENESIS 35 539 0.0001151 0.003563
152 ANGIOGENESIS 23 293 0.0001164 0.003563
153 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 88 1805 0.0001218 0.003704
154 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 16 166 0.0001244 0.003758
155 POSITIVE REGULATION OF GENE EXPRESSION 85 1733 0.0001315 0.003948
156 SINGLE ORGANISM CELL ADHESION 31 459 0.0001397 0.00414
157 MESENCHYMAL CELL DIFFERENTIATION 14 134 0.0001388 0.00414
158 REGULATION OF CATION CHANNEL ACTIVITY 11 88 0.0001463 0.004307
159 POSITIVE REGULATION OF AXON EXTENSION 7 36 0.0001482 0.004337
160 CELL GROWTH 14 135 0.0001503 0.00437
161 REGULATED EXOCYTOSIS 19 224 0.0001663 0.004806
162 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 21 262 0.0001706 0.00484
163 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 89 1848 0.0001692 0.00484
164 MYELIN ASSEMBLY 5 17 0.0001702 0.00484
165 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 41 684 0.000176 0.004963
166 AXON EXTENSION 7 37 0.0001776 0.004979
167 POSITIVE REGULATION OF RESPONSE TO STIMULUS 92 1929 0.0001825 0.005053
168 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 8 49 0.0001819 0.005053
169 NEGATIVE REGULATION OF CELL DEVELOPMENT 23 303 0.0001909 0.005225
170 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 23 303 0.0001909 0.005225
171 NEGATIVE REGULATION OF AXON GUIDANCE 6 27 0.0002048 0.005574
172 TELENCEPHALON DEVELOPMENT 19 228 0.000209 0.005654
173 REGULATION OF SEQUESTERING OF CALCIUM ION 12 107 0.000211 0.005676
174 DEPHOSPHORYLATION 22 286 0.0002167 0.00578
175 PROTEIN AUTOPHOSPHORYLATION 17 192 0.0002174 0.00578
176 MEMBRANE ORGANIZATION 50 899 0.0002193 0.005797
177 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 0.0002211 0.005811
178 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 5 18 0.0002293 0.005962
179 POSITIVE REGULATION OF CELL DEVELOPMENT 31 472 0.0002288 0.005962
180 CONNECTIVE TISSUE DEVELOPMENT 17 194 0.0002459 0.006356
181 REGULATION OF GTPASE ACTIVITY 40 673 0.0002504 0.006438
182 COGNITION 20 251 0.0002612 0.00664
183 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 19 232 0.000261 0.00664
184 EXOCYTOSIS 23 310 0.0002657 0.006705
185 NEGATIVE REGULATION OF AXONOGENESIS 9 65 0.0002666 0.006705
186 SECOND MESSENGER MEDIATED SIGNALING 15 160 0.0002716 0.006794
187 CELLULAR RESPONSE TO OXYGEN LEVELS 14 143 0.0002754 0.006852
188 DEVELOPMENTAL GROWTH 24 333 0.0003027 0.007492
189 GLAND DEVELOPMENT 27 395 0.0003057 0.007526
190 CEREBRAL CORTEX RADIALLY ORIENTED CELL MIGRATION 6 29 0.0003108 0.007611
191 POSITIVE REGULATION OF NEURON MIGRATION 4 11 0.0003204 0.007804
192 CELL JUNCTION ASSEMBLY 13 129 0.0003398 0.008235
193 MUSCLE CELL DIFFERENTIATION 19 237 0.0003416 0.008236
194 MUSCLE ORGAN DEVELOPMENT 21 277 0.0003633 0.008714
195 CARTILAGE DEVELOPMENT 14 147 0.000366 0.008733
196 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 48 873 0.0003781 0.008841
197 CEREBELLAR CORTEX MORPHOGENESIS 6 30 0.0003778 0.008841
198 REGULATION OF ION HOMEOSTASIS 17 201 0.0003728 0.008841
199 ORGAN GROWTH 9 68 0.0003765 0.008841
200 CEREBRAL CORTEX RADIAL GLIA GUIDED MIGRATION 5 20 0.0003929 0.009005
201 TELENCEPHALON GLIAL CELL MIGRATION 5 20 0.0003929 0.009005
202 PROTEIN STABILIZATION 13 131 0.0003948 0.009005
203 REGULATION OF POTASSIUM ION TRANSPORT 10 83 0.0003928 0.009005
204 SINGLE ORGANISM CELLULAR LOCALIZATION 49 898 0.000391 0.009005
205 MODULATION OF SYNAPTIC TRANSMISSION 22 301 0.0004398 0.009982
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 54 640 2.626e-10 2.439e-07
2 CYTOSKELETAL PROTEIN BINDING 59 819 1.517e-08 5.232e-06
3 KINASE ACTIVITY 60 842 1.689e-08 5.232e-06
4 RIBONUCLEOTIDE BINDING 100 1860 6.072e-07 0.000141
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 62 992 9.996e-07 0.0001857
6 ENZYME BINDING 93 1737 1.91e-06 0.0002958
7 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 13 81 2.294e-06 0.0003044
8 PROTEIN TYROSINE KINASE ACTIVITY 19 176 5.913e-06 0.0006866
9 ACTIN BINDING 31 393 7.315e-06 0.0007551
10 ZINC ION BINDING 66 1155 9.085e-06 0.0008283
11 ADENYL NUCLEOTIDE BINDING 81 1514 9.808e-06 0.0008283
12 VOLTAGE GATED ION CHANNEL ACTIVITY 19 190 1.781e-05 0.00137
13 TRANSITION METAL ION BINDING 75 1400 2.064e-05 0.00137
14 MACROMOLECULAR COMPLEX BINDING 75 1399 2.015e-05 0.00137
15 PROTEIN COMPLEX BINDING 55 935 2.377e-05 0.001472
16 TUBULIN BINDING 23 273 3.959e-05 0.002163
17 PDZ DOMAIN BINDING 12 90 3.875e-05 0.002163
18 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 10 64 4.283e-05 0.002211
19 UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING 7 34 0.0001011 0.004944
20 CHANNEL REGULATOR ACTIVITY 14 131 0.0001088 0.005055
21 MICROTUBULE BINDING 18 201 0.0001242 0.005495
22 CALCIUM ION BINDING 42 697 0.0001313 0.005542
23 MOLECULAR FUNCTION REGULATOR 69 1353 0.0001972 0.007299
24 CORECEPTOR ACTIVITY 7 38 0.0002116 0.007299
25 PROTEIN SERINE THREONINE KINASE ACTIVITY 30 445 0.0001838 0.007299
26 CHEMOREPELLENT ACTIVITY 6 27 0.0002048 0.007299
27 GROWTH FACTOR BINDING 13 123 0.0002121 0.007299
28 KINASE BINDING 37 606 0.0002531 0.008398
29 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 16 178 0.0002782 0.008913
30 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 28 417 0.000318 0.009847
31 PHOSPHATASE ACTIVITY 21 275 0.0003298 0.009883
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 91 1265 1.266e-12 7.392e-10
2 NEURON PROJECTION 71 942 6.252e-11 1.826e-08
3 CELL PROJECTION 109 1786 1.68e-10 3.271e-08
4 CYTOSKELETON 109 1967 3.606e-08 5.265e-06
5 SOMATODENDRITIC COMPARTMENT 49 650 6.741e-08 7.874e-06
6 SYNAPSE 52 754 4.379e-07 4.263e-05
7 CATION CHANNEL COMPLEX 20 167 6.588e-07 5.496e-05
8 CELL JUNCTION 69 1151 1.067e-06 7.787e-05
9 DENDRITE 35 451 2.741e-06 0.0001779
10 SARCOLEMMA 16 125 3.577e-06 0.0002089
11 CELL PROJECTION PART 56 946 1.673e-05 0.0008882
12 PLASMA MEMBRANE RAFT 12 86 2.438e-05 0.001187
13 MICROTUBULE CYTOSKELETON 60 1068 3.869e-05 0.001329
14 MICROTUBULE 30 405 3.388e-05 0.001329
15 MEMBRANE MICRODOMAIN 24 288 3.231e-05 0.001329
16 ANCHORING JUNCTION 34 489 3.789e-05 0.001329
17 PLASMA MEMBRANE PROTEIN COMPLEX 35 510 3.82e-05 0.001329
18 CELL SUBSTRATE JUNCTION 29 398 6.123e-05 0.001987
19 EXTRACELLULAR MATRIX COMPONENT 14 125 6.525e-05 0.002006
20 EXCITATORY SYNAPSE 18 197 9.612e-05 0.002715
21 T TUBULE 8 45 9.762e-05 0.002715
22 CELL BODY 33 494 0.0001057 0.002807
23 PROTEINACEOUS EXTRACELLULAR MATRIX 26 356 0.0001397 0.003548
24 PRIMARY CILIUM 18 205 0.0001593 0.003876
25 BASEMENT MEMBRANE 11 93 0.0002402 0.00561
26 COSTAMERE 5 19 0.0003029 0.006802
27 POSTSYNAPSE 26 378 0.0003569 0.007443
28 MEMBRANE REGION 59 1134 0.0003505 0.007443
29 CYTOSKELETAL PART 71 1436 0.0003891 0.007836
30 EXTRACELLULAR MATRIX 28 426 0.000447 0.008702
31 PLASMA MEMBRANE REGION 50 929 0.0004668 0.008794

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 25 199 1.021e-08 5.309e-07
2 MAPK_signaling_pathway_hsa04010 27 295 1.839e-06 4.782e-05
3 Regulation_of_actin_cytoskeleton_hsa04810 21 208 5.626e-06 9.751e-05
4 Rap1_signaling_pathway_hsa04015 19 206 5.465e-05 0.0007105
5 Autophagy_animal_hsa04140 14 128 8.463e-05 0.0008456
6 cGMP_PKG_signaling_pathway_hsa04022 16 163 0.0001003 0.0008456
7 Calcium_signaling_pathway_hsa04020 17 182 0.0001138 0.0008456
8 mTOR_signaling_pathway_hsa04150 15 151 0.0001434 0.0009323
9 Oocyte_meiosis_hsa04114 13 124 0.00023 0.001329
10 Hippo_signaling_pathway_multiple_species_hsa04392 6 29 0.0003108 0.001616
11 ECM_receptor_interaction_hsa04512 10 82 0.0003558 0.001682
12 PI3K_Akt_signaling_pathway_hsa04151 24 352 0.0006709 0.002907
13 ErbB_signaling_pathway_hsa04012 9 85 0.001919 0.007209
14 Apelin_signaling_pathway_hsa04371 12 137 0.001941 0.007209
15 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 12 139 0.002193 0.007602
16 cAMP_signaling_pathway_hsa04024 15 198 0.00242 0.007864
17 Ras_signaling_pathway_hsa04014 16 232 0.004476 0.01369
18 AMPK_signaling_pathway_hsa04152 10 121 0.006733 0.01945
19 Gap_junction_hsa04540 8 88 0.008474 0.02319
20 Wnt_signaling_pathway_hsa04310 11 146 0.009067 0.02339
21 Adherens_junction_hsa04520 7 72 0.009446 0.02339
22 FoxO_signaling_pathway_hsa04068 10 132 0.01208 0.02855
23 Phosphatidylinositol_signaling_system_hsa04070 8 99 0.01653 0.03737
24 HIF_1_signaling_pathway_hsa04066 8 100 0.01747 0.03785
25 Jak_STAT_signaling_pathway_hsa04630 11 162 0.01858 0.03866
26 Mitophagy_animal_hsa04137 6 65 0.01997 0.03994
27 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.02289 0.04408
28 Hippo_signaling_pathway_hsa04390 10 154 0.03155 0.05859
29 Hedgehog_signaling_pathway_hsa04340 4 47 0.06845 0.1227
30 p53_signaling_pathway_hsa04115 5 68 0.07332 0.1271
31 Cellular_senescence_hsa04218 9 160 0.083 0.1392
32 Endocytosis_hsa04144 12 244 0.1098 0.1785
33 VEGF_signaling_pathway_hsa04370 4 59 0.1295 0.2041
34 TNF_signaling_pathway_hsa04668 6 108 0.1464 0.2239
35 Tight_junction_hsa04530 8 170 0.1994 0.2926
36 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.2026 0.2926
37 Notch_signaling_pathway_hsa04330 3 48 0.2099 0.295
38 Apoptosis_hsa04210 6 138 0.3035 0.4153
39 Phagosome_hsa04145 6 152 0.3855 0.514
40 ABC_transporters_hsa02010 2 45 0.4393 0.5711
41 TGF_beta_signaling_pathway_hsa04350 3 84 0.5263 0.6675
42 Sphingolipid_signaling_pathway_hsa04071 4 118 0.5479 0.6783
43 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.61 0.7376
44 Cell_cycle_hsa04110 3 124 0.78 0.863
45 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.8992 0.9741
46 Cytokine_cytokine_receptor_interaction_hsa04060 5 270 0.9455 0.9833
47 Necroptosis_hsa04217 2 164 0.9734 0.984

Quest ID: ee1b443570fa05c04731a1609ab13e1f