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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-192-5p BUB1B -0.47 0 1.31 0 miRNAWalker2 validate -0.22 0.00092 NA
2 hsa-miR-486-5p BUB1B -2.71 0 1.31 0 miRanda -0.17 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 9 192 1.024e-09 8.332e-07
2 REGULATION OF LIGASE ACTIVITY 8 130 1.095e-09 8.332e-07
3 POSITIVE REGULATION OF LIGASE ACTIVITY 8 110 2.866e-10 8.332e-07
4 CELL CYCLE 18 1316 1.139e-09 8.332e-07
5 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 10 274 1.253e-09 8.332e-07
6 POSITIVE REGULATION OF PROTEOLYSIS 11 363 1.201e-09 8.332e-07
7 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 9 196 1.228e-09 8.332e-07
8 POSITIVE REGULATION OF CATABOLIC PROCESS 11 395 2.906e-09 1.502e-06
9 REGULATION OF PROTEIN CATABOLIC PROCESS 11 393 2.756e-09 1.502e-06
10 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 7 103 6.51e-09 3.029e-06
11 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 9 263 1.605e-08 6.788e-06
12 PROTEASOMAL PROTEIN CATABOLIC PROCESS 9 271 2.079e-08 8.062e-06
13 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 9 280 2.755e-08 9.862e-06
14 CELL CYCLE PROCESS 15 1081 3.363e-08 1.118e-05
15 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 6 77 3.709e-08 1.151e-05
16 REGULATION OF PROTEOLYSIS 12 711 1.304e-07 3.793e-05
17 REGULATION OF CATABOLIC PROCESS 12 731 1.759e-07 4.816e-05
18 MITOTIC CELL CYCLE 12 766 2.908e-07 7.516e-05
19 REGULATION OF TRANSFERASE ACTIVITY 13 946 3.798e-07 9.161e-05
20 REGULATION OF CELL CYCLE 13 949 3.937e-07 9.161e-05
21 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 6 139 1.25e-06 0.0002769
22 PROTEIN CATABOLIC PROCESS 10 579 1.385e-06 0.0002929
23 PROTEIN POLYUBIQUITINATION 7 243 2.295e-06 0.000416
24 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 2.414e-06 0.000416
25 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 8 351 2.346e-06 0.000416
26 REGULATION OF MITOTIC CELL CYCLE 9 468 2.082e-06 0.000416
27 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 10 616 2.414e-06 0.000416
28 PROTEIN UBIQUITINATION 10 629 2.908e-06 0.0004833
29 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 6.665e-06 0.001069
30 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 6 197 9.377e-06 0.001454
31 REGULATION OF WNT SIGNALING PATHWAY 7 310 1.133e-05 0.001602
32 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 14 1492 1.133e-05 0.001602
33 REGULATION OF PROTEIN MODIFICATION PROCESS 15 1710 1.136e-05 0.001602
34 POSITIVE REGULATION OF CATALYTIC ACTIVITY 14 1518 1.379e-05 0.001835
35 MACROMOLECULE CATABOLIC PROCESS 11 926 1.403e-05 0.001835
36 REGULATION OF CELL CYCLE PHASE TRANSITION 7 321 1.42e-05 0.001835
37 CELLULAR CATABOLIC PROCESS 13 1322 1.536e-05 0.001932
38 CELL DIVISION 8 460 1.695e-05 0.002046
39 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 1.715e-05 0.002046
40 POSITIVE REGULATION OF MOLECULAR FUNCTION 15 1791 1.977e-05 0.0023
41 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 134 2.084e-05 0.002365
42 FC EPSILON RECEPTOR SIGNALING PATHWAY 5 142 2.755e-05 0.003052
43 T CELL RECEPTOR SIGNALING PATHWAY 5 146 3.148e-05 0.003364
44 PROTEOLYSIS 12 1208 3.181e-05 0.003364
45 PROTEIN K11 LINKED UBIQUITINATION 3 27 4.122e-05 0.004262
46 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 10 873 5e-05 0.005057
47 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 5 162 5.174e-05 0.005122
48 NIK NF KAPPAB SIGNALING 4 83 5.491e-05 0.005323
49 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 11 1087 6.13e-05 0.005821
50 REGULATION OF CELL CYCLE PROCESS 8 558 6.676e-05 0.006213
51 CATABOLIC PROCESS 14 1773 7.745e-05 0.007066
52 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 5 181 8.75e-05 0.00783
NumGOOverlapSizeP ValueAdj. P Value
1 MICROTUBULE MOTOR ACTIVITY 5 77 1.372e-06 0.001275
2 CULLIN FAMILY PROTEIN BINDING 3 12 3.184e-06 0.001479
3 MOTOR ACTIVITY 5 131 1.868e-05 0.005784
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEAR UBIQUITIN LIGASE COMPLEX 5 42 6.309e-08 3.684e-05
2 KINESIN COMPLEX 5 55 2.518e-07 3.797e-05
3 ANAPHASE PROMOTING COMPLEX 4 22 2.445e-07 3.797e-05
4 UBIQUITIN LIGASE COMPLEX 8 262 2.601e-07 3.797e-05
5 MICROTUBULE CYTOSKELETON 13 1068 1.493e-06 0.0001743
6 CULLIN RING UBIQUITIN LIGASE COMPLEX 6 150 1.949e-06 0.0001897
7 TRANSFERASE COMPLEX 10 703 7.769e-06 0.0006481
8 MICROTUBULE ASSOCIATED COMPLEX 5 145 3.046e-05 0.002223
9 CATALYTIC COMPLEX 11 1038 4.031e-05 0.002616
10 MICROTUBULE 7 405 6.25e-05 0.00365
11 CYTOSKELETAL PART 12 1436 0.0001681 0.008925

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Oocyte_meiosis_hsa04114 5 124 1.432e-05 0.0007445
2 Cell_cycle_hsa04110 4 124 0.00026 0.00676
3 Mitophagy_animal_hsa04137 2 65 0.01152 0.1772
4 TGF_beta_signaling_pathway_hsa04350 2 84 0.01874 0.1772
5 ErbB_signaling_pathway_hsa04012 2 85 0.01916 0.1772
6 Gap_junction_hsa04540 2 88 0.02045 0.1772
7 Sphingolipid_signaling_pathway_hsa04071 2 118 0.03518 0.2613
8 Apoptosis_hsa04210 2 138 0.04669 0.2983
9 Wnt_signaling_pathway_hsa04310 2 146 0.05163 0.2983
10 Tight_junction_hsa04530 2 170 0.06749 0.3509
11 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.2197 0.6756

Quest ID: f1940a11990d582c39be2f51612e7b7d