CR2Cancer

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00022 Actin

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	9845365

> Gene Ontology [ TOP ]
Biological Process	GO:0000422 mitophagy GO:0001654 eye development GO:0003407 neural retina development GO:0006310 DNA recombination GO:0006338 chromatin remodeling GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006914 autophagy GO:0007423 sensory organ development GO:0010506 regulation of autophagy GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0021510 spinal cord development GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0043010 camera-type eye development GO:0043044 ATP-dependent chromatin remodeling GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0051222 positive regulation of protein transport GO:0060041 retina development in camera-type eye GO:0061726 mitochondrion disassembly GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:1903008 organelle disassembly GO:1903146 regulation of mitophagy GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016514 SWI/SNF complex GO:0031011 Ino80 complex GO:0031248 protein acetyltransferase complex GO:0033202 DNA helicase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0071564 npBAF complex GO:0090544 BAF-type complex GO:0097346 INO80-type complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-3214847: HATs acetylate histones R-HSA-392499: Metabolism of proteins R-HSA-5696398: Nucleotide Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-3214858: RMTs methylate histone arginines R-HSA-5689603: UCH proteinases

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-5696394: DNA Damage Recognition in GG-NER
R-HSA-73894: DNA Repair
R-HSA-5688426: Deubiquitination
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-3214847: HATs acetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-597592: Post-translational protein modification
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-5689603: UCH proteinases

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM308850	c.113C>G	p.P38R	Substitution - Missense	Soft_tissue
COSM4854811	c.121A>G	p.I41V	Substitution - Missense	Cervix
COSM3590425	c.33T>C	p.V11V	Substitution - coding silent	Skin
COSM5620200	c.320A>G	p.Y107C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4659108	c.146A>G	p.D49G	Substitution - Missense	Large_intestine
COSM1421066	c.751C>T	p.H251Y	Substitution - Missense	Large_intestine
COSM3205844	c.131T>C	p.V44A	Substitution - Missense	Large_intestine
COSM4837005	c.627C>T	p.L209L	Substitution - coding silent	Cervix
COSM729789	c.476+1G>T	p.?	Unknown	Lung
COSM273860	c.402G>T	p.E134D	Substitution - Missense	Large_intestine
COSM4898504	c.772G>A	p.V258I	Substitution - Missense	Skin
COSM5348037	c.830+3delA	p.?	Unknown	Liver
COSM5917955	c.572-5C>T	p.?	Unknown	Skin
COSM1308847	c.504G>A	p.L168L	Substitution - coding silent	Urinary_tract
COSM308850	c.113C>G	p.P38R	Substitution - Missense	Lung
COSM5518493	c.234G>A	p.P78P	Substitution - coding silent	Biliary_tract
COSM4659110	c.572-1G>T	p.?	Unknown	Large_intestine
COSM5806936	c.667A>T	p.I223F	Substitution - Missense	Liver
COSM5491744	c.1213A>G	p.T405A	Substitution - Missense	Biliary_tract
COSM729788	c.1048G>A	p.V350M	Substitution - Missense	Lung
COSM729792	c.132G>T	p.V44V	Substitution - coding silent	Lung
COSM4763722	c.1189G>A	p.G397S	Substitution - Missense	Stomach
COSM4801877	c.775A>G	p.I259V	Substitution - Missense	Liver
COSM1421064	c.315T>C	p.H105H	Substitution - coding silent	Large_intestine
COSM77210	c.196C>T	p.P66S	Substitution - Missense	Ovary
COSM3846799	c.333C>G	p.V111V	Substitution - coding silent	Breast
COSM5939054	c.451C>T	p.L151F	Substitution - Missense	Skin
COSM1308848	c.723G>C	p.E241D	Substitution - Missense	Urinary_tract
COSM5367653	c.263_264insA	p.N90fs*5	Insertion - Frameshift	Large_intestine
COSM4854811	c.121A>G	p.I41V	Substitution - Missense	Upper_aerodigestive_tract
COSM4659112	c.1064C>T	p.T355I	Substitution - Missense	Large_intestine
COSM1041555	c.490C>T	p.R164C	Substitution - Missense	Bone
COSM1283239	c.233C>T	p.P78L	Substitution - Missense	Autonomic_ganglia
COSM4434834	c.1188C>T	p.G396G	Substitution - coding silent	Oesophagus
COSM1632997	c.65C>G	p.T22S	Substitution - Missense	Liver
COSM1308849	c.1117C>T	p.P373S	Substitution - Missense	Urinary_tract
COSM4772737	c.491G>T	p.R164L	Substitution - Missense	Stomach
COSM3846800	c.781G>A	p.D261N	Substitution - Missense	Breast
COSM4625016	c.366G>A	p.M122I	Substitution - Missense	Large_intestine
COSM1041559	c.794C>T	p.S265L	Substitution - Missense	Endometrium
COSM1041557	c.716G>T	p.R239I	Substitution - Missense	Endometrium
COSM1617229	c.629T>G	p.F210C	Substitution - Missense	Liver
COSM5743008	c.830+2T>C	p.?	Unknown	Small_intestine
COSM1670717	c.785T>G	p.F262C	Substitution - Missense	Large_intestine
COSM5911826	c.1123-6T>A	p.?	Unknown	Skin
COSM170469	c.1129C>T	p.R377W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4801877	c.775A>G	p.I259V	Substitution - Missense	Liver
COSM4115474	c.901C>T	p.R301W	Substitution - Missense	Stomach
COSM1421065	c.750G>A	p.W250*	Substitution - Nonsense	Large_intestine
COSM4115477	c.1265A>C	p.Q422P	Substitution - Missense	Stomach
COSM5059513	c.211G>T	p.D71Y	Substitution - Missense	Stomach
COSM1193019	c.487delG	p.G163fs*6	Deletion - Frameshift	Lung
COSM378774	c.931C>T	p.P311S	Substitution - Missense	Lung
COSM1181716	c.471G>T	p.L157F	Substitution - Missense	Large_intestine
COSM5398699	c.1169G>A	p.R390K	Substitution - Missense	Skin
COSM3774731	c.370G>C	p.E124Q	Substitution - Missense	Urinary_tract
COSM1683970	c.269delA	p.N90fs*47	Deletion - Frameshift	Large_intestine
COSM3590426	c.59C>T	p.S20F	Substitution - Missense	Skin
COSM479748	c.990C>A	p.T330T	Substitution - coding silent	Kidney
COSM1163334	c.246G>A	p.M82I	Substitution - Missense	Pancreas
COSM1617229	c.629T>G	p.F210C	Substitution - Missense	Liver
COSM3205846	c.264delA	p.N90fs*47	Deletion - Frameshift	Large_intestine
COSM5555884	c.193G>A	p.G65S	Substitution - Missense	Prostate
COSM215895	c.491G>A	p.R164H	Substitution - Missense	Central_nervous_system
COSM1041556	c.521C>T	p.A174V	Substitution - Missense	Endometrium
COSM5978752	c.678_678+1insGAAGCT	p.A228_V229insEA	Insertion - In frame	Upper_aerodigestive_tract
COSM5026083	c.733C>T	p.Q245*	Substitution - Nonsense	Breast
COSM479747	c.446T>C	p.F149S	Substitution - Missense	Kidney
COSM4659111	c.934T>C	p.S312P	Substitution - Missense	Large_intestine
COSM1670717	c.785T>G	p.F262C	Substitution - Missense	Large_intestine
COSM5623249	c.1074G>C	p.Q358H	Substitution - Missense	Oesophagus
COSM348036	c.310G>C	p.D104H	Substitution - Missense	Lung
COSM419697	c.280G>A	p.E94K	Substitution - Missense	Urinary_tract
COSM4847047	c.630C>G	p.F210L	Substitution - Missense	Cervix
COSM4115447	c.476+2T>C	p.?	Unknown	Stomach
COSM4817833	c.1289G>C	p.*430S	Nonstop extension	Cervix
COSM4980397	c.740C>T	p.T247M	Substitution - Missense	Oesophagus
COSM1041560	c.1087A>G	p.R363G	Substitution - Missense	Endometrium
COSM729790	c.398G>T	p.R133I	Substitution - Missense	Lung
COSM3992877	c.919G>T	p.G307*	Substitution - Nonsense	Kidney
COSM1041558	c.769T>C	p.C257R	Substitution - Missense	Endometrium
COSM5736835	c.634G>T	p.E212*	Substitution - Nonsense	Small_intestine
COSM1193019	c.487delG	p.G163fs*6	Deletion - Frameshift	Lung
COSM3590427	c.450C>T	p.F150F	Substitution - coding silent	Skin
COSM5455167	c.950T>C	p.L317S	Substitution - Missense	Large_intestine
COSM4115473	c.752A>G	p.H251R	Substitution - Missense	Stomach
COSM4115476	c.976A>C	p.S326R	Substitution - Missense	Stomach
COSM4115475	c.947G>A	p.G316E	Substitution - Missense	Stomach
COSM1041561	c.1151A>T	p.N384I	Substitution - Missense	Endometrium
COSM3992878	c.1130G>A	p.R377Q	Substitution - Missense	Kidney
COSM1041555	c.490C>T	p.R164C	Substitution - Missense	Endometrium
COSM1041554	c.489T>G	p.G163G	Substitution - coding silent	Endometrium
COSM4659109	c.505A>G	p.I169V	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for ACTL6A.

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O96019	86	S	Phosphoserine	-	No	None detected
O96019	233	S	Phosphoserine	-	No	None detected

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.971	6.173	1.167	2.09e-14	Over
BRCA	Breast invasive carcinoma	112	1100	5.191	6.02	0.89	8.85e-49	Over
CESC	Cervical and endocervical cancers	3	306	5.264	6.768	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.447	6.382	0.84	1.07e-21	Over
ESCA	Esophageal carcinoma	11	185	4.784	6.166	1.515	1.19e-09	Over
GBM	Glioblastoma multiforme	5	166	2.729	5.698	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.279	6.235	1.073	3.52e-20	Over
KIRC	Kidney renal clear cell carcinoma	72	534	5.07	4.993	-0.108	0.0521	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.865	5.065	0.209	0.0203	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.64	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.736	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.767	4.315	0.544	2.55e-08	NS
LUAD	Lung adenocarcinoma	59	517	4.823	5.696	0.894	1.4e-22	Over
LUSC	Lung squamous cell carcinoma	51	501	4.862	7.128	2.273	1.12e-61	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.478	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.064	5.314	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.381	4.451	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.045	5.33	0.265	6.2e-05	NS
READ	Rectum adenocarcinoma	10	167	5.705	6.407	0.621	0.00102	Over
SARC	Sarcoma	2	263	4.634	5.352	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.427	5.722	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.867	5.832	0.886	1.28e-14	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.037	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.915	5.091	0.148	0.00654	NS
THYM	Thymoma	2	120	5.579	5.625	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.254	5.768	0.567	1.71e-06	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.2
Autonomic ganglia	CHP212	10.5
Autonomic ganglia	IMR32	10.2
Autonomic ganglia	KELLY	11.6
Autonomic ganglia	KPNRTBM1	10.7
Autonomic ganglia	KPNSI9S	10.3
Autonomic ganglia	KPNYN	11
Autonomic ganglia	MHHNB11	9.7
Autonomic ganglia	NB1	10.8
Autonomic ganglia	NH6	10.4
Autonomic ganglia	SHSY5Y	10.5
Autonomic ganglia	SIMA	10.2
Autonomic ganglia	SKNAS	9.4
Autonomic ganglia	SKNBE2	11.1
Autonomic ganglia	SKNDZ	11.1
Autonomic ganglia	SKNFI	9.5
Autonomic ganglia	SKNSH	10.2
Biliary tract	HUCCT1	10.6
Biliary tract	HUH28	10.4
Biliary tract	SNU1079	10
Biliary tract	SNU1196	10.9
Biliary tract	SNU245	10.3
Biliary tract	SNU308	10.1
Biliary tract	SNU478	10
Bone	143B	11
Bone	A673	10.7
Bone	CADOES1	9.6
Bone	CAL78	10.5
Bone	G292CLONEA141B1	10.4
Bone	HOS	11
Bone	HS706T	10.1
Bone	HS737T	9.3
Bone	HS819T	9.6
Bone	HS821T	9.1
Bone	HS822T	9.6
Bone	HS863T	9.6
Bone	HS870T	10.1
Bone	HS888T	9.7
Bone	MG63	10.9
Bone	MHHES1	10
Bone	OUMS27	9.8
Bone	RDES	9.6
Bone	SJSA1	10
Bone	SKES1	10.6
Bone	SKNMC	10.9
Bone	SW1353	9.6
Bone	T173	9.3
Bone	TC71	10.4
Bone	U2OS	10.5
Breast	AU565	10.2
Breast	BT20	10.3
Breast	BT474	11.4
Breast	BT483	10.2
Breast	BT549	10.1
Breast	CAL120	10.4
Breast	CAL148	11
Breast	CAL51	10.2
Breast	CAL851	11.1
Breast	CAMA1	10.9
Breast	DU4475	10.2
Breast	EFM192A	10.2
Breast	EFM19	10.8
Breast	EVSAT	10.4
Breast	HCC1143	10.5
Breast	HCC1187	9.7
Breast	HCC1395	10
Breast	HCC1419	10.1
Breast	HCC1428	11.5
Breast	HCC1500	11.4
Breast	HCC1569	10.5
Breast	HCC1599	11.3
Breast	HCC1806	10.8
Breast	HCC1937	11.2
Breast	HCC1954	10.9
Breast	HCC202	10.7
Breast	HCC2157	10.4
Breast	HCC2218	10.4
Breast	HCC38	10.9
Breast	HCC70	11.3
Breast	HDQP1	10.5
Breast	HMC18	11.6
Breast	HS274T	9.3
Breast	HS281T	9.8
Breast	HS343T	9.9
Breast	HS578T	10.3
Breast	HS606T	10.2
Breast	HS739T	9.5
Breast	HS742T	9.5
Breast	JIMT1	11.1
Breast	KPL1	10.4
Breast	MCF7	10.6
Breast	MDAMB134VI	10.1
Breast	MDAMB157	10.5
Breast	MDAMB175VII	10
Breast	MDAMB231	10.4
Breast	MDAMB361	10.1
Breast	MDAMB415	11.1
Breast	MDAMB436	9.1
Breast	MDAMB453	10.7
Breast	MDAMB468	10.3
Breast	SKBR3	10.5
Breast	T47D	11.2
Breast	UACC812	10.7
Breast	UACC893	10.4
Breast	YMB1	9.9
Breast	ZR751	11
Breast	ZR7530	10.2
Central nervous system	1321N1	10.9
Central nervous system	42MGBA	9.9
Central nervous system	8MGBA	11.2
Central nervous system	A172	10.8
Central nervous system	AM38	10.5
Central nervous system	BECKER	11.1
Central nervous system	CAS1	10.5
Central nervous system	CCFSTTG1	10.4
Central nervous system	D283MED	10
Central nervous system	D341MED	9.7
Central nervous system	DAOY	11.5
Central nervous system	DBTRG05MG	9.6
Central nervous system	DKMG	10.2
Central nervous system	GAMG	11.1
Central nervous system	GB1	10.8
Central nervous system	GI1	10.2
Central nervous system	GMS10	10.2
Central nervous system	GOS3	9.4
Central nervous system	H4	10.1
Central nervous system	HS683	10.7
Central nervous system	KALS1	10.6
Central nervous system	KG1C	9.5
Central nervous system	KNS42	10.4
Central nervous system	KNS60	11.3
Central nervous system	KNS81	9.9
Central nervous system	KS1	10.9
Central nervous system	LN18	9.7
Central nervous system	LN229	10.2
Central nervous system	M059K	9.8
Central nervous system	MOGGCCM	10
Central nervous system	MOGGUVW	10.8
Central nervous system	NMCG1	10.3
Central nervous system	ONS76	10.5
Central nervous system	SF126	11
Central nervous system	SF295	9.8
Central nervous system	SNB19	10.4
Central nervous system	SNU1105	10
Central nervous system	SNU201	9.2
Central nervous system	SNU466	9.5
Central nervous system	SNU489	9
Central nervous system	SNU626	10.1
Central nervous system	SNU738	10.8
Central nervous system	SW1088	10.3
Central nervous system	SW1783	11.1
Central nervous system	T98G	9.8
Central nervous system	TM31	10.4
Central nervous system	U118MG	10.7
Central nervous system	U138MG	10.5
Central nervous system	U251MG	10
Central nervous system	U87MG	9.5
Central nervous system	YH13	9.5
Central nervous system	YKG1	11.1
Endometrium	AN3CA	9.9
Endometrium	COLO684	10.1
Endometrium	EFE184	10.7
Endometrium	EN	9.6
Endometrium	ESS1	10.8
Endometrium	HEC108	9.6
Endometrium	HEC151	10.1
Endometrium	HEC1A	11.2
Endometrium	HEC1B	11.2
Endometrium	HEC251	11.2
Endometrium	HEC265	10.5
Endometrium	HEC50B	11.5
Endometrium	HEC59	11.1
Endometrium	HEC6	11.3
Endometrium	ISHIKAWAHERAKLIO02ER	10.5
Endometrium	JHUEM1	8.9
Endometrium	JHUEM2	10.8
Endometrium	JHUEM3	10.5
Endometrium	KLE	10.5
Endometrium	MFE280	10.5
Endometrium	MFE296	9.5
Endometrium	MFE319	8.9
Endometrium	RL952	9.3
Endometrium	SNGM	10.4
Endometrium	SNU1077	9.9
Endometrium	SNU685	10.4
Endometrium	TEN	10.9
Haematopoietic and lymphoid	697	10.8
Haematopoietic and lymphoid	A3KAW	10.8
Haematopoietic and lymphoid	A4FUK	10.5
Haematopoietic and lymphoid	ALLSIL	10.6
Haematopoietic and lymphoid	AML193	11.3
Haematopoietic and lymphoid	AMO1	10.6
Haematopoietic and lymphoid	BCP1	10.4
Haematopoietic and lymphoid	BDCM	10.6
Haematopoietic and lymphoid	BL41	11.2
Haematopoietic and lymphoid	BL70	10.9
Haematopoietic and lymphoid	BV173	9.9
Haematopoietic and lymphoid	CA46	10
Haematopoietic and lymphoid	CI1	10.5
Haematopoietic and lymphoid	CMK115	11
Haematopoietic and lymphoid	CMK86	11.1
Haematopoietic and lymphoid	CMK	9.4
Haematopoietic and lymphoid	CMLT1	9.5
Haematopoietic and lymphoid	COLO775	11.2
Haematopoietic and lymphoid	DAUDI	10.5
Haematopoietic and lymphoid	DB	10.4
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	10.5
Haematopoietic and lymphoid	DOHH2	10.5
Haematopoietic and lymphoid	EB1	9.8
Haematopoietic and lymphoid	EB2	9.7
Haematopoietic and lymphoid	EHEB	9.6
Haematopoietic and lymphoid	EJM	10.2
Haematopoietic and lymphoid	EM2	10.7
Haematopoietic and lymphoid	EOL1	10.1
Haematopoietic and lymphoid	F36P	9.8
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	10.2
Haematopoietic and lymphoid	GRANTA519	10.1
Haematopoietic and lymphoid	HDLM2	11.2
Haematopoietic and lymphoid	HDMYZ	11.1
Haematopoietic and lymphoid	HEL9217	10.7
Haematopoietic and lymphoid	HEL	10.6
Haematopoietic and lymphoid	HH	11.2
Haematopoietic and lymphoid	HL60	10.7
Haematopoietic and lymphoid	HPBALL	10.2
Haematopoietic and lymphoid	HS604T	9.1
Haematopoietic and lymphoid	HS611T	10.1
Haematopoietic and lymphoid	HS616T	9.4
Haematopoietic and lymphoid	HS751T	10.3
Haematopoietic and lymphoid	HT	10.7
Haematopoietic and lymphoid	HTK	11.1
Haematopoietic and lymphoid	HUNS1	10.2
Haematopoietic and lymphoid	HUT102	9.8
Haematopoietic and lymphoid	HUT78	10.5
Haematopoietic and lymphoid	JEKO1	10.5
Haematopoietic and lymphoid	JK1	9.6
Haematopoietic and lymphoid	JM1	10.8
Haematopoietic and lymphoid	JURKAT	9.4
Haematopoietic and lymphoid	JURLMK1	10.5
Haematopoietic and lymphoid	JVM2	10
Haematopoietic and lymphoid	JVM3	10.1
Haematopoietic and lymphoid	K562	10.1
Haematopoietic and lymphoid	KARPAS299	10
Haematopoietic and lymphoid	KARPAS422	9.7
Haematopoietic and lymphoid	KARPAS620	10.5
Haematopoietic and lymphoid	KASUMI1	10.8
Haematopoietic and lymphoid	KASUMI2	9.9
Haematopoietic and lymphoid	KASUMI6	10.6
Haematopoietic and lymphoid	KCL22	10.6
Haematopoietic and lymphoid	KE37	10.5
Haematopoietic and lymphoid	KE97	10.2
Haematopoietic and lymphoid	KG1	11
Haematopoietic and lymphoid	KHM1B	10.9
Haematopoietic and lymphoid	KIJK	10.6
Haematopoietic and lymphoid	KMH2	10.7
Haematopoietic and lymphoid	KMM1	10.5
Haematopoietic and lymphoid	KMS11	10.6
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	10.5
Haematopoietic and lymphoid	KMS20	10.1
Haematopoietic and lymphoid	KMS21BM	10.1
Haematopoietic and lymphoid	KMS26	10.7
Haematopoietic and lymphoid	KMS27	10.4
Haematopoietic and lymphoid	KMS28BM	10.7
Haematopoietic and lymphoid	KMS34	11.4
Haematopoietic and lymphoid	KO52	10.7
Haematopoietic and lymphoid	KOPN8	10.5
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	9.5
Haematopoietic and lymphoid	L1236	10.8
Haematopoietic and lymphoid	L363	11.3
Haematopoietic and lymphoid	L428	10.5
Haematopoietic and lymphoid	L540	10
Haematopoietic and lymphoid	LAMA84	9.9
Haematopoietic and lymphoid	LOUCY	11.1
Haematopoietic and lymphoid	LP1	9.8
Haematopoietic and lymphoid	M07E	10.8
Haematopoietic and lymphoid	MC116	10.8
Haematopoietic and lymphoid	ME1	10.4
Haematopoietic and lymphoid	MEC1	10.3
Haematopoietic and lymphoid	MEC2	10.3
Haematopoietic and lymphoid	MEG01	10.2
Haematopoietic and lymphoid	MHHCALL2	10.9
Haematopoietic and lymphoid	MHHCALL3	10.3
Haematopoietic and lymphoid	MHHCALL4	10.5
Haematopoietic and lymphoid	MINO	9.9
Haematopoietic and lymphoid	MJ	10.7
Haematopoietic and lymphoid	MM1S	11
Haematopoietic and lymphoid	MOLM13	10.6
Haematopoietic and lymphoid	MOLM16	10.7
Haematopoietic and lymphoid	MOLM6	9.6
Haematopoietic and lymphoid	MOLP2	9
Haematopoietic and lymphoid	MOLP8	10.1
Haematopoietic and lymphoid	MOLT13	10.4
Haematopoietic and lymphoid	MOLT16	10
Haematopoietic and lymphoid	MOLT4	10.6
Haematopoietic and lymphoid	MONOMAC1	10.5
Haematopoietic and lymphoid	MONOMAC6	10.1
Haematopoietic and lymphoid	MOTN1	10.3
Haematopoietic and lymphoid	MUTZ5	10.4
Haematopoietic and lymphoid	MV411	10.7
Haematopoietic and lymphoid	NALM19	10.9
Haematopoietic and lymphoid	NALM1	10.4
Haematopoietic and lymphoid	NALM6	10.5
Haematopoietic and lymphoid	NAMALWA	11
Haematopoietic and lymphoid	NB4	10.7
Haematopoietic and lymphoid	NCIH929	10.3
Haematopoietic and lymphoid	NCO2	10.4
Haematopoietic and lymphoid	NOMO1	10.9
Haematopoietic and lymphoid	NUDHL1	9.4
Haematopoietic and lymphoid	NUDUL1	9.8
Haematopoietic and lymphoid	OCIAML2	10.3
Haematopoietic and lymphoid	OCIAML3	9.1
Haematopoietic and lymphoid	OCIAML5	9.7
Haematopoietic and lymphoid	OCILY10	10.1
Haematopoietic and lymphoid	OCILY19	10.4
Haematopoietic and lymphoid	OCILY3	10.8
Haematopoietic and lymphoid	OCIM1	9.4
Haematopoietic and lymphoid	OPM2	10.7
Haematopoietic and lymphoid	P12ICHIKAWA	10.8
Haematopoietic and lymphoid	P31FUJ	10.5
Haematopoietic and lymphoid	P3HR1	10.4
Haematopoietic and lymphoid	PCM6	9.6
Haematopoietic and lymphoid	PEER	11.3
Haematopoietic and lymphoid	PF382	10.3
Haematopoietic and lymphoid	PFEIFFER	11
Haematopoietic and lymphoid	PL21	10.6
Haematopoietic and lymphoid	RAJI	10.5
Haematopoietic and lymphoid	RCHACV	11.1
Haematopoietic and lymphoid	REC1	10.6
Haematopoietic and lymphoid	REH	11
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	10.5
Haematopoietic and lymphoid	RPMI8226	11.4
Haematopoietic and lymphoid	RPMI8402	11.1
Haematopoietic and lymphoid	RS411	10.8
Haematopoietic and lymphoid	SEM	11
Haematopoietic and lymphoid	SET2	10.4
Haematopoietic and lymphoid	SIGM5	10.9
Haematopoietic and lymphoid	SKM1	11.1
Haematopoietic and lymphoid	SKMM2	10.3
Haematopoietic and lymphoid	SR786	10.2
Haematopoietic and lymphoid	ST486	11.4
Haematopoietic and lymphoid	SUDHL10	10
Haematopoietic and lymphoid	SUDHL1	10.7
Haematopoietic and lymphoid	SUDHL4	10.1
Haematopoietic and lymphoid	SUDHL5	11
Haematopoietic and lymphoid	SUDHL6	10.2
Haematopoietic and lymphoid	SUDHL8	10.6
Haematopoietic and lymphoid	SUPB15	10.5
Haematopoietic and lymphoid	SUPHD1	10
Haematopoietic and lymphoid	SUPM2	10.8
Haematopoietic and lymphoid	SUPT11	9.9
Haematopoietic and lymphoid	SUPT1	10.6
Haematopoietic and lymphoid	TALL1	10.7
Haematopoietic and lymphoid	TF1	11
Haematopoietic and lymphoid	THP1	10.5
Haematopoietic and lymphoid	TO175T	9.7
Haematopoietic and lymphoid	TOLEDO	10.6
Haematopoietic and lymphoid	U266B1	10.2
Haematopoietic and lymphoid	U937	9.9
Haematopoietic and lymphoid	UT7	10.3
Haematopoietic and lymphoid	WSUDLCL2	9.9
Kidney	769P	10.2
Kidney	786O	9.8
Kidney	A498	9.5
Kidney	A704	9.5
Kidney	ACHN	10.5
Kidney	BFTC909	10.5
Kidney	CAKI1	9.8
Kidney	CAKI2	11
Kidney	CAL54	9.7
Kidney	KMRC1	11
Kidney	KMRC20	10.5
Kidney	KMRC2	10.4
Kidney	KMRC3	9.3
Kidney	OSRC2	10.7
Kidney	RCC10RGB	9.8
Kidney	SNU1272	10.2
Kidney	SNU349	10.1
Kidney	TUHR10TKB	10.5
Kidney	TUHR14TKB	9.5
Kidney	TUHR4TKB	10.6
Kidney	VMRCRCW	10.3
Kidney	VMRCRCZ	10
Large intestine	C2BBE1	10.4
Large intestine	CCK81	10.9
Large intestine	CL11	10.7
Large intestine	CL14	9.4
Large intestine	CL34	10.5
Large intestine	CL40	9.9
Large intestine	COLO205	11.3
Large intestine	COLO320	11.2
Large intestine	COLO678	10.7
Large intestine	CW2	10.7
Large intestine	DLD1	10.9
Large intestine	GP2D	10.2
Large intestine	HCC56	11.1
Large intestine	HCT116	10
Large intestine	HCT15	10.5
Large intestine	HS675T	9.4
Large intestine	HS698T	9.3
Large intestine	HT115	10.9
Large intestine	HT29	10.8
Large intestine	HT55	9.8
Large intestine	KM12	10.7
Large intestine	LOVO	11.2
Large intestine	LS1034	10.9
Large intestine	LS123	11
Large intestine	LS180	10
Large intestine	LS411N	11
Large intestine	LS513	11.2
Large intestine	MDST8	10.6
Large intestine	NCIH508	10.8
Large intestine	NCIH716	10.4
Large intestine	NCIH747	11.2
Large intestine	OUMS23	9.9
Large intestine	RCM1	10.8
Large intestine	RKO	10.7
Large intestine	SKCO1	9.8
Large intestine	SNU1040	10.2
Large intestine	SNU1197	10.7
Large intestine	SNU175	10.2
Large intestine	SNU283	10.6
Large intestine	SNU407	10
Large intestine	SNU503	10.9
Large intestine	SNU61	11.1
Large intestine	SNU81	10.3
Large intestine	SNUC1	10.9
Large intestine	SNUC2A	10
Large intestine	SNUC4	10.8
Large intestine	SNUC5	10.7
Large intestine	SW1116	10.7
Large intestine	SW1417	11.3
Large intestine	SW1463	10.8
Large intestine	SW403	11.4
Large intestine	SW480	11.1
Large intestine	SW48	10.4
Large intestine	SW620	10.5
Large intestine	SW837	11.1
Large intestine	SW948	11.1
Large intestine	T84	11.2
Liver	ALEXANDERCELLS	9.5
Liver	C3A	10
Liver	HEP3B217	11.7
Liver	HEPG2	9.5
Liver	HLE	10.8
Liver	HLF	10.8
Liver	HUH1	9.6
Liver	HUH6	11.3
Liver	HUH7	10.8
Liver	JHH1	10.1
Liver	JHH2	10.3
Liver	JHH4	10.4
Liver	JHH5	10.2
Liver	JHH6	10
Liver	JHH7	10
Liver	LI7	10.1
Liver	PLCPRF5	8.7
Liver	SKHEP1	10.3
Liver	SNU182	10
Liver	SNU387	10.2
Liver	SNU398	10.6
Liver	SNU423	9.9
Liver	SNU449	9.5
Liver	SNU475	10.2
Liver	SNU761	9.7
Liver	SNU878	11.3
Liver	SNU886	10.9
Lung	A549	10.2
Lung	ABC1	11.6
Lung	BEN	9.8
Lung	CAL12T	10.6
Lung	CALU1	10.6
Lung	CALU3	11.1
Lung	CALU6	10
Lung	CHAGOK1	11.4
Lung	COLO668	10.7
Lung	COLO699	10.5
Lung	CORL105	10.5
Lung	CORL23	10.8
Lung	CORL24	10.7
Lung	CORL279	11.3
Lung	CORL311	9.9
Lung	CORL47	11.8
Lung	CORL51	11.1
Lung	CORL88	10.8
Lung	CORL95	10.5
Lung	CPCN	10.9
Lung	DMS114	10.7
Lung	DMS153	11.5
Lung	DMS273	10.6
Lung	DMS454	11.3
Lung	DMS53	9.8
Lung	DMS79	11.4
Lung	DV90	10.5
Lung	EBC1	11
Lung	EPLC272H	10
Lung	HARA	11.5
Lung	HCC1171	10.6
Lung	HCC1195	10.6
Lung	HCC15	9.4
Lung	HCC2279	10.3
Lung	HCC2935	10.2
Lung	HCC33	11.2
Lung	HCC366	11.1
Lung	HCC4006	10.7
Lung	HCC44	10.7
Lung	HCC78	10.7
Lung	HCC827	10.5
Lung	HCC95	11.9
Lung	HLC1	10.4
Lung	HLFA	9.6
Lung	HS229T	10.5
Lung	HS618T	10.1
Lung	IALM	8.7
Lung	KNS62	10.9
Lung	LC1F	11.9
Lung	LC1SQSF	11.7
Lung	LCLC103H	10.1
Lung	LCLC97TM1	10.4
Lung	LK2	11
Lung	LOUNH91	9.5
Lung	LU65	10.7
Lung	LU99	11
Lung	LUDLU1	11.4
Lung	LXF289	9.9
Lung	MORCPR	9.9
Lung	NCIH1048	11.3
Lung	NCIH1092	11.1
Lung	NCIH1105	11.7
Lung	NCIH1155	11.1
Lung	NCIH1184	11.6
Lung	NCIH1299	10.9
Lung	NCIH1339	10.4
Lung	NCIH1341	10.1
Lung	NCIH1355	9.4
Lung	NCIH1373	10.1
Lung	NCIH1385	9.2
Lung	NCIH1395	9.7
Lung	NCIH1435	10.2
Lung	NCIH1436	10.9
Lung	NCIH1437	10.7
Lung	NCIH146	11.4
Lung	NCIH1563	9.9
Lung	NCIH1568	10.4
Lung	NCIH1573	9.5
Lung	NCIH1581	10.5
Lung	NCIH1618	11.4
Lung	NCIH1623	10.3
Lung	NCIH1648	10.9
Lung	NCIH1650	10.2
Lung	NCIH1651	10.4
Lung	NCIH1666	10.3
Lung	NCIH1693	10.4
Lung	NCIH1694	11.4
Lung	NCIH1703	11.2
Lung	NCIH1734	11.5
Lung	NCIH1755	9.9
Lung	NCIH1781	11.1
Lung	NCIH1792	9.5
Lung	NCIH1793	9.9
Lung	NCIH1836	11.1
Lung	NCIH1838	10.4
Lung	NCIH1869	10.6
Lung	NCIH1876	10.4
Lung	NCIH1915	11
Lung	NCIH1930	10.5
Lung	NCIH1944	10.2
Lung	NCIH1963	11.1
Lung	NCIH196	11
Lung	NCIH1975	10.6
Lung	NCIH2009	10.6
Lung	NCIH2023	11.3
Lung	NCIH2029	10.5
Lung	NCIH2030	9.7
Lung	NCIH2066	9.9
Lung	NCIH2081	10.9
Lung	NCIH2085	9.3
Lung	NCIH2087	10
Lung	NCIH209	10.6
Lung	NCIH2106	11
Lung	NCIH2110	11.4
Lung	NCIH211	10.8
Lung	NCIH2122	9.7
Lung	NCIH2126	9.2
Lung	NCIH2141	11.1
Lung	NCIH2170	10.3
Lung	NCIH2171	10.4
Lung	NCIH2172	10.5
Lung	NCIH2196	11.3
Lung	NCIH2227	10.6
Lung	NCIH2228	10.8
Lung	NCIH226	9.9
Lung	NCIH2286	10.3
Lung	NCIH2291	10.5
Lung	NCIH2342	10.5
Lung	NCIH2347	10.7
Lung	NCIH23	10.6
Lung	NCIH2405	10.8
Lung	NCIH2444	10.6
Lung	NCIH292	10
Lung	NCIH322	11.2
Lung	NCIH3255	10.4
Lung	NCIH358	10.7
Lung	NCIH441	10.3
Lung	NCIH446	10.5
Lung	NCIH460	11.1
Lung	NCIH510	10.7
Lung	NCIH520	10.9
Lung	NCIH522	10.5
Lung	NCIH524	11.3
Lung	NCIH526	10.6
Lung	NCIH596	10.1
Lung	NCIH647	10.1
Lung	NCIH650	9.1
Lung	NCIH661	10.3
Lung	NCIH69	11.3
Lung	NCIH727	10.8
Lung	NCIH810	11.3
Lung	NCIH82	11
Lung	NCIH838	11.6
Lung	NCIH841	10.3
Lung	NCIH854	10.2
Lung	NCIH889	10.7
Lung	PC14	11.3
Lung	RERFLCAD1	10.8
Lung	RERFLCAD2	10.3
Lung	RERFLCAI	10.6
Lung	RERFLCKJ	10.1
Lung	RERFLCMS	10.3
Lung	RERFLCSQ1	11.9
Lung	SBC5	10.1
Lung	SCLC21H	10.7
Lung	SHP77	10.7
Lung	SKLU1	9.6
Lung	SKMES1	9.6
Lung	SQ1	11.2
Lung	SW1271	10.4
Lung	SW1573	10
Lung	SW900	9.3
Lung	VMRCLCD	11.3
Lung	VMRCLCP	11.2
Oesophagus	COLO680N	9.9
Oesophagus	ECGI10	10.4
Oesophagus	KYSE140	11.8
Oesophagus	KYSE150	10.6
Oesophagus	KYSE180	12
Oesophagus	KYSE270	10.9
Oesophagus	KYSE30	10.3
Oesophagus	KYSE410	11.5
Oesophagus	KYSE450	10
Oesophagus	KYSE510	11
Oesophagus	KYSE520	10.1
Oesophagus	KYSE70	11.8
Oesophagus	OE19	10.9
Oesophagus	OE33	11.2
Oesophagus	TE10	11.6
Oesophagus	TE11	11
Oesophagus	TE14	11.1
Oesophagus	TE15	10.8
Oesophagus	TE1	11
Oesophagus	TE4	10.4
Oesophagus	TE5	11.9
Oesophagus	TE6	11.1
Oesophagus	TE8	11.1
Oesophagus	TE9	10.3
Oesophagus	TT	11.1
Ovary	59M	10.3
Ovary	A2780	10.9
Ovary	CAOV3	10.9
Ovary	CAOV4	10.4
Ovary	COLO704	10.5
Ovary	COV318	10
Ovary	COV362	11.1
Ovary	COV434	10.8
Ovary	COV504	10.8
Ovary	COV644	10.8
Ovary	EFO21	10.3
Ovary	EFO27	9.5
Ovary	ES2	11.1
Ovary	FUOV1	10.7
Ovary	HEYA8	11.3
Ovary	HS571T	8.7
Ovary	IGROV1	9.8
Ovary	JHOC5	10.8
Ovary	JHOM1	9.9
Ovary	JHOM2B	10.8
Ovary	JHOS2	11.3
Ovary	JHOS4	10.6
Ovary	KURAMOCHI	10.3
Ovary	MCAS	10.6
Ovary	NIHOVCAR3	10.6
Ovary	OAW28	11.6
Ovary	OAW42	10.5
Ovary	OC314	10.3
Ovary	OC316	10.5
Ovary	ONCODG1	10.6
Ovary	OV56	9.5
Ovary	OV7	10.4
Ovary	OV90	9.9
Ovary	OVCAR4	10.9
Ovary	OVCAR8	10.6
Ovary	OVISE	10.7
Ovary	OVK18	10.6
Ovary	OVKATE	11.6
Ovary	OVMANA	9.6
Ovary	OVSAHO	10.2
Ovary	OVTOKO	10.2
Ovary	RMGI	10
Ovary	RMUGS	10.5
Ovary	SKOV3	10.8
Ovary	SNU119	10.9
Ovary	SNU840	10.1
Ovary	SNU8	10.6
Ovary	TOV112D	10.3
Ovary	TOV21G	9.9
Ovary	TYKNU	10.7
Pancreas	ASPC1	9.2
Pancreas	BXPC3	9.9
Pancreas	CAPAN1	10.4
Pancreas	CAPAN2	9.8
Pancreas	CFPAC1	10
Pancreas	DANG	11.1
Pancreas	HPAC	10
Pancreas	HPAFII	10.9
Pancreas	HS766T	9
Pancreas	HUPT3	10.4
Pancreas	HUPT4	10.6
Pancreas	KCIMOH1	10.2
Pancreas	KLM1	10.9
Pancreas	KP2	10.5
Pancreas	KP3	10.7
Pancreas	KP4	11.2
Pancreas	L33	10.8
Pancreas	MIAPACA2	11
Pancreas	PANC0203	11.2
Pancreas	PANC0213	9.4
Pancreas	PANC0327	11.1
Pancreas	PANC0403	10.2
Pancreas	PANC0504	10
Pancreas	PANC0813	10.8
Pancreas	PANC1005	10.7
Pancreas	PANC1	11
Pancreas	PATU8902	11.6
Pancreas	PATU8988S	11.1
Pancreas	PATU8988T	10.9
Pancreas	PK1	10.5
Pancreas	PK45H	11.1
Pancreas	PK59	9.6
Pancreas	PL45	10.8
Pancreas	PSN1	10.1
Pancreas	QGP1	10.5
Pancreas	SNU213	10.4
Pancreas	SNU324	10.1
Pancreas	SNU410	10.2
Pancreas	SU8686	10
Pancreas	SUIT2	10.8
Pancreas	SW1990	11.2
Pancreas	T3M4	11.2
Pancreas	TCCPAN2	11
Pancreas	YAPC	9.8
Pleura	ACCMESO1	10.9
Pleura	DM3	9.4
Pleura	ISTMES1	10.5
Pleura	ISTMES2	9.3
Pleura	JL1	9.4
Pleura	MPP89	10.3
Pleura	MSTO211H	10.5
Pleura	NCIH2052	9.6
Pleura	NCIH2452	10.8
Pleura	NCIH28	10.2
Prostate	22RV1	11
Prostate	DU145	11
Prostate	LNCAPCLONEFGC	10.2
Prostate	MDAPCA2B	10.3
Prostate	NCIH660	11.9
Prostate	PC3	10.6
Prostate	VCAP	10.2
Salivary gland	A253	11.5
Salivary gland	YD15	11.2
Skin	A101D	10.5
Skin	A2058	10.2
Skin	A375	10
Skin	C32	10.6
Skin	CHL1	10.6
Skin	CJM	10.8
Skin	COLO679	10.4
Skin	COLO741	10.3
Skin	COLO783	9.5
Skin	COLO792	10.9
Skin	COLO800	10.1
Skin	COLO818	10.8
Skin	COLO829	10.3
Skin	COLO849	10.8
Skin	G361	11.1
Skin	GRM	10.4
Skin	HMCB	11.1
Skin	HS294T	9.3
Skin	HS600T	9.7
Skin	HS688AT	9.5
Skin	HS695T	10.2
Skin	HS839T	10.2
Skin	HS852T	10
Skin	HS895T	9.9
Skin	HS934T	9.9
Skin	HS936T	9.7
Skin	HS939T	10.3
Skin	HS940T	9.3
Skin	HS944T	10
Skin	HT144	11
Skin	IGR1	9.8
Skin	IGR37	11.1
Skin	IGR39	10.2
Skin	IPC298	10.5
Skin	K029AX	10.2
Skin	LOXIMVI	10.7
Skin	MALME3M	9.7
Skin	MDAMB435S	10.4
Skin	MELHO	10.7
Skin	MELJUSO	10.5
Skin	MEWO	10.6
Skin	RPMI7951	10.5
Skin	RVH421	10
Skin	SH4	10.6
Skin	SKMEL1	10.1
Skin	SKMEL24	9.6
Skin	SKMEL28	10.9
Skin	SKMEL2	10.8
Skin	SKMEL30	10.6
Skin	SKMEL31	9.8
Skin	SKMEL3	9
Skin	SKMEL5	10.1
Skin	UACC257	10.2
Skin	UACC62	10.5
Skin	WM115	9.9
Skin	WM1799	9.9
Skin	WM2664	10.5
Skin	WM793	10
Skin	WM88	9.9
Skin	WM983B	11
Small intestine	HUTU80	10.5
Soft tissue	A204	10.6
Soft tissue	G401	10.1
Soft tissue	G402	10.6
Soft tissue	GCT	10.2
Soft tissue	HS729	10.7
Soft tissue	HT1080	10.7
Soft tissue	KYM1	10.7
Soft tissue	MESSA	9.8
Soft tissue	RD	10.3
Soft tissue	RH30	10.5
Soft tissue	RH41	10.4
Soft tissue	RKN	10.2
Soft tissue	S117	10.3
Soft tissue	SJRH30	9.9
Soft tissue	SKLMS1	10.3
Soft tissue	SKUT1	10.5
Soft tissue	TE125T	9.7
Soft tissue	TE159T	9.3
Soft tissue	TE441T	9.4
Soft tissue	TE617T	10
Stomach	2313287	10.3
Stomach	AGS	10.7
Stomach	AZ521	10.9
Stomach	ECC10	10.4
Stomach	ECC12	11
Stomach	FU97	10.5
Stomach	GCIY	11.1
Stomach	GSS	10.7
Stomach	GSU	11.5
Stomach	HGC27	10.5
Stomach	HS746T	10.1
Stomach	HUG1N	11.3
Stomach	IM95	11
Stomach	KATOIII	11.5
Stomach	KE39	10.7
Stomach	LMSU	10.9
Stomach	MKN1	10.9
Stomach	MKN45	10.8
Stomach	MKN74	11.3
Stomach	MKN7	10.4
Stomach	NCCSTCK140	10.7
Stomach	NCIN87	10.8
Stomach	NUGC2	10
Stomach	NUGC3	10.2
Stomach	NUGC4	10.3
Stomach	OCUM1	10.2
Stomach	RERFGC1B	10.5
Stomach	SH10TC	10.8
Stomach	SNU16	10
Stomach	SNU1	11
Stomach	SNU216	9.8
Stomach	SNU520	11
Stomach	SNU5	10.4
Stomach	SNU601	11.4
Stomach	SNU620	10.9
Stomach	SNU668	10.2
Stomach	SNU719	9.9
Stomach	TGBC11TKB	10.2
Thyroid	8305C	10.2
Thyroid	8505C	10.8
Thyroid	BCPAP	8
Thyroid	BHT101	10.2
Thyroid	CAL62	11
Thyroid	CGTHW1	11
Thyroid	FTC133	10.3
Thyroid	FTC238	12.1
Thyroid	ML1	9.8
Thyroid	SW579	10.5
Thyroid	TT2609C02	10.6
Thyroid	TT	9
Upper aerodigestive tract	BHY	9.4
Upper aerodigestive tract	BICR16	11
Upper aerodigestive tract	BICR18	11.3
Upper aerodigestive tract	BICR22	11.7
Upper aerodigestive tract	BICR31	11.6
Upper aerodigestive tract	BICR56	9.9
Upper aerodigestive tract	BICR6	11.3
Upper aerodigestive tract	CAL27	9.9
Upper aerodigestive tract	CAL33	10.1
Upper aerodigestive tract	DETROIT562	10.7
Upper aerodigestive tract	FADU	11
Upper aerodigestive tract	HS840T	9.7
Upper aerodigestive tract	HSC2	11
Upper aerodigestive tract	HSC3	10.9
Upper aerodigestive tract	HSC4	10
Upper aerodigestive tract	PECAPJ15	10.4
Upper aerodigestive tract	PECAPJ34CLONEC12	11
Upper aerodigestive tract	PECAPJ41CLONED2	10.2
Upper aerodigestive tract	PECAPJ49	10.7
Upper aerodigestive tract	SCC15	10.6
Upper aerodigestive tract	SCC25	10.9
Upper aerodigestive tract	SCC4	10
Upper aerodigestive tract	SCC9	9.7
Upper aerodigestive tract	SNU1076	9.9
Upper aerodigestive tract	SNU1214	11.2
Upper aerodigestive tract	SNU46	9.4
Upper aerodigestive tract	SNU899	10.9
Upper aerodigestive tract	YD10B	10.8
Upper aerodigestive tract	YD38	10.4
Upper aerodigestive tract	YD8	8.4
Urinary tract	5637	10.1
Urinary tract	639V	9.4
Urinary tract	647V	11.1
Urinary tract	BC3C	10.4
Urinary tract	BFTC905	11.1
Urinary tract	CAL29	10.6
Urinary tract	HS172T	9.5
Urinary tract	HT1197	10.5
Urinary tract	HT1376	10.4
Urinary tract	J82	10.3
Urinary tract	JMSU1	10.9
Urinary tract	KMBC2	10.6
Urinary tract	KU1919	9.9
Urinary tract	RT11284	10.8
Urinary tract	RT112	10.9
Urinary tract	RT4	10.6
Urinary tract	SCABER	10.7
Urinary tract	SW1710	10.3
Urinary tract	SW780	10.3
Urinary tract	T24	10.1
Urinary tract	TCCSUP	10.8
Urinary tract	UMUC1	10.5
Urinary tract	UMUC3	11.1
Urinary tract	VMCUB1	10.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	20.8
Adrenal gland	26.6
Appendix	32.3
Bone marrow	10.7
Breast	40.4
Cerebral cortex	13.5
Cervix, uterine	37.2
Colon	31.5
Duodenum	25.3
Endometrium	45.5
Epididymis	31
Esophagus	26.5
Fallopian tube	39.6
Gallbladder	24.5
Heart muscle	12.5
Kidney	23.7
Liver	11.1
Lung	28.2
Lymph node	37.3
Ovary	39
Pancreas	3.3
Parathyroid gland	34.6
Placenta	33.3
Prostate	34.3
Rectum	42.4
Salivary gland	9.1
Seminal vesicle	29.6
Skeletal muscle	3.6
Skin	31.5
Small intestine	26.8
Smooth muscle	37.8
Spleen	27.8
Stomach	21
Testis	111.9
Thyroid gland	34.2
Tonsil	39.1
Urinary bladder	27.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28260090	Overexpression	Osteosarcoma	In this study, the results showed that, by analysis of frozen fresh primary tumor tissues, matched non-cancerous bone tissues(NCBTs) and biopsy lung metastatic nodule tissues from 30osteosarcoma patients after radical surgical resection, ACTL6A was overexpressed in osteosarcoma tissues compared with matched NCBTs, and its expression level was associated with osteosarcoma metastasis.
28041841	Overexpression (copy number gain)	Head and Neck Squamous Cell Carcinoma	Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and highly expressed together with the p53 family member p63 in head and neck squamous cell carcinoma (HNSCC).
23728344	Overexpression	Rhabdomyosarcoma	Here we show that the BAF53a transcript is significantly higher in primary RMS tumors than in normal muscle, and is a direct target of miR-206.
26698646	Overexpression	Hepatocellular Carcinoma	A high level of ACTL6A in HCCs is correlated with aggressive clinicopathological features and is an independent poor prognostic factor for overall and disease-free survival of HCC patients.

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.609	1.89e-42	2.7	43.1	54.2	Gain
BRCA	Breast invasive carcinoma	1075	0.664	7.91e-138	5.4	63.6	31	Neutral
CESC	Cervical and endocervical cancers	292	0.76	3.47e-56	1	23.3	75.7	Gain
COAD	Colon adenocarcinoma	449	0.382	5.09e-17	7.1	75.9	16.9	Neutral
ESCA	Esophageal carcinoma	183	0.794	6.76e-41	6	29	65	Gain
GBM	Glioblastoma multiforme	147	0.445	1.62e-08	4.8	73.5	21.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.754	2.42e-95	1.4	26.3	72.4	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.449	2.41e-27	11.8	72	16.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.381	2.35e-11	1.7	63.5	34.7	Gain
LAML	Acute Myeloid Leukemia	166	0.171	0.0272	1.8	97.6	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.295	9.19e-12	5.1	91.2	3.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.422	3.8e-17	11.5	70.9	17.6	Neutral
LUAD	Lung adenocarcinoma	512	0.657	1.21e-64	23	48	28.9	Neutral
LUSC	Lung squamous cell carcinoma	498	0.798	3.03e-111	0.6	9.2	90.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.706	1.69e-46	1.3	16.7	82	Gain
PAAD	Pancreatic adenocarcinoma	177	0.52	1.19e-13	10.2	74.6	15.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.71	3.6e-26	58	42	0	Loss
PRAD	Prostate adenocarcinoma	491	0.396	7.19e-20	2.2	82.9	14.9	Neutral
READ	Rectum adenocarcinoma	164	0.481	6.75e-11	6.1	71.3	22.6	Neutral
SARC	Sarcoma	255	0.539	1.25e-20	20	63.1	16.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.63	4.86e-42	15.5	64.3	20.2	Neutral
STAD	Stomach adenocarcinoma	413	0.587	1.2e-39	8	55.4	36.6	Gain
TGCT	Testicular Germ Cell Tumors	150	0.465	1.95e-09	12.7	55.3	32	Neutral
THCA	Thyroid carcinoma	497	0.078	0.0839	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.166	0.0706	5	90.8	4.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.592	3.46e-52	1.5	70	28.5	Neutral

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.298	4.34e-10	17	408	0.004	0.519	NS/NA
BRCA	Breast invasive carcinoma	-0.19	1.73e-08	83	785	-0.016	0.0458	NS/NA
CESC	Cervical and endocervical cancers	-0.593	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.151	0.00719	19	297	0.009	0.00134	NS/NA
ESCA	Esophageal carcinoma	-0.526	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.109	0.388	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.54	0	20	522	-0.017	9.71e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.261	1.02e-06	24	319	0.025	3.23e-19	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.203	0.000436	23	275	0.005	0.123	NS/NA
LAML	Acute Myeloid Leukemia	-0.061	0.429	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.115	0.00793	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.184	0.000166	41	373	-0.001	0.292	NS/NA
LUAD	Lung adenocarcinoma	-0.205	6.61e-06	21	456	-0.01	0.408	NS/NA
LUSC	Lung squamous cell carcinoma	-0.62	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.667	0.0589	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.166	0.0248	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.626	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.254	2.96e-09	35	498	-0.006	0.367	NS/NA
READ	Rectum adenocarcinoma	-0.225	0.024	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.176	0.00414	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.345	1.72e-14	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.19	0.000229	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.333	2.46e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.008	0.85	50	509	-0.011	0.08	NS/NA
THYM	Thymoma	-0.232	0.0103	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.343	3.61e-14	34	431	0	0.609	NS/NA

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.301	NS	24476821
BRCA	Breast invasive carcinoma	521	3.96e-20	Significant	23000897
COAD	Colon adenocarcinoma	149	0.254	NS	22810696
GBM	Glioblastoma multiforme	157	0.311	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.01e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.763	NS	26536169
LGG	Brain Lower Grade Glioma	513	8.84e-05	Significant	26824661
LUAD	Lung adenocarcinoma	230	7.66e-09	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.96e-13	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000209	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0146	Significant	26544944
READ	Rectum adenocarcinoma	67	0.03	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0155	Significant	26091043
STAD	Stomach adenocarcinoma	277	9.44e-13	Significant	25079317
THCA	Thyroid carcinoma	391	5.54e-31	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000258	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.171	0.461	NS
BRCA	Breast invasive carcinoma	1079	1.472	0.119	NS
CESC	Cervical and endocervical cancers	291	0.794	0.489	NS
COAD	Colon adenocarcinoma	439	0.576	0.0526	NS
ESCA	Esophageal carcinoma	184	1.408	0.297	NS
GBM	Glioblastoma multiforme	158	0.562	0.023	Longer
HNSC	Head and Neck squamous cell carcinoma	518	1.342	0.154	NS
KIRC	Kidney renal clear cell carcinoma	531	0.943	0.768	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.654	0.22	NS
LAML	Acute Myeloid Leukemia	149	0.711	0.231	NS
LGG	Brain Lower Grade Glioma	511	3.061	2.31e-05	Shorter
LIHC	Liver hepatocellular carcinoma	365	2.05	0.00145	Shorter
LUAD	Lung adenocarcinoma	502	1.92	0.00284	Shorter
LUSC	Lung squamous cell carcinoma	494	0.743	0.11	NS
OV	Ovarian serous cystadenocarcinoma	303	0.923	0.701	NS
PAAD	Pancreatic adenocarcinoma	177	4.056	5.49e-06	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	1.453	0.76	NS
PRAD	Prostate adenocarcinoma	497	4.708	0.122	NS
READ	Rectum adenocarcinoma	159	0.499	0.206	NS
SARC	Sarcoma	259	2.666	0.000915	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.125	0.553	NS
STAD	Stomach adenocarcinoma	388	0.904	0.642	NS
TGCT	Testicular Germ Cell Tumors	134	0.983	0.99	NS
THCA	Thyroid carcinoma	500	0.337	0.112	NS
THYM	Thymoma	119	1.074	0.96	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.692	0.0679	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.011	0.83	NS
BRCA	Breast invasive carcinoma	1071	0.019	0.537	NS
CESC	Cervical and endocervical cancers	167	-0.066	0.396	NS
COAD	Colon adenocarcinoma	445	0.049	0.305	NS
ESCA	Esophageal carcinoma	162	0.096	0.224	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.057	0.229	NS
KIRC	Kidney renal clear cell carcinoma	531	0.049	0.257	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.188	0.00228	Higher
LIHC	Liver hepatocellular carcinoma	347	0.172	0.0013	Higher
LUAD	Lung adenocarcinoma	507	0.08	0.0715	NS
LUSC	Lung squamous cell carcinoma	497	0.013	0.772	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.123	0.0327	Lower
PAAD	Pancreatic adenocarcinoma	176	0.152	0.0438	Higher
READ	Rectum adenocarcinoma	156	-0.023	0.773	NS
SKCM	Skin Cutaneous Melanoma	410	-0.029	0.556	NS
STAD	Stomach adenocarcinoma	392	-0.023	0.655	NS
TGCT	Testicular Germ Cell Tumors	81	-0.087	0.44	NS
THCA	Thyroid carcinoma	499	0.008	0.853	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.173	0.000102	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.045	0.457	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.111	0.0131	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.004	0.929	NS
LGG	Brain Lower Grade Glioma	514	0.266	8.8e-10	Higher
LIHC	Liver hepatocellular carcinoma	366	0.247	1.67e-06	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.001	0.992	NS
PAAD	Pancreatic adenocarcinoma	176	0.219	0.00345	Higher
STAD	Stomach adenocarcinoma	406	-0.165	0.000865	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.345	2.3e-16	Higher

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

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> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for ACTL6A.

Summary
Symbol	ACTL6A
Name	actin like 6A
Aliases	BAF53A; INO80K; BAF complex 53 kDa subunit; BRG1-associated factor; actin-related protein 4; INO80 complex s ......
Location	3q26.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

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> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28041841	Head and Neck Squamous Cell Carcinoma	partner	p63	Collaboration	ACTL6A and p63 physically interact, cooperatively controlling a transcriptional program that promotes proliferation and suppresses differentiation, in part through activation of the Hippo-YAP pathway via regulators including WWC1.
23728344	Rhabdomyosarcoma	upstream	miR-206	negative regulation	In this work, we focused on BAF53a, one of the genes downregulated in miR-206-expressing RMS cells, which codes for a subunit of the SWI/SNF chromatin remodeling complex. Here we show that the BAF53a transcript is significantly higher in primary RMS tumors than in normal muscle, and is a direct target of miR-206.
26698646	Hepatocellular Carcinoma	downstream	SOX2; Notch1	positive regulation	Further studies indicate that ACTL6A might manipulate SRY (sex determining region Y)-box 2 (SOX2) expression and then activate Notch1 signaling. Mechanism studies show that ACTL6A enhances SRY (sex determining region Y)-box 2 (SOX2) expression in HCC, which up-regulates Notch1 expression and triggers Notch signaling in HCC.