CR2Cancer

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00046 Homeobox domain

Function

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	17878164

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006182 cGMP biosynthetic process GO:0006471 protein ADP-ribosylation GO:0006486 protein glycosylation GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0007611 learning or memory GO:0007613 memory GO:0007614 short-term memory GO:0008361 regulation of cell size GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009743 response to carbohydrate GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010559 regulation of glycoprotein biosynthetic process GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010835 regulation of protein ADP-ribosylation GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022604 regulation of cell morphogenesis GO:0030307 positive regulation of cell growth GO:0030516 regulation of axon extension GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030826 regulation of cGMP biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0031346 positive regulation of cell projection organization GO:0031668 cellular response to extracellular stimulus GO:0032091 negative regulation of protein binding GO:0032147 activation of protein kinase activity GO:0032535 regulation of cellular component size GO:0033483 gas homeostasis GO:0033484 nitric oxide homeostasis GO:0033674 positive regulation of kinase activity GO:0042698 ovulation cycle GO:0043393 regulation of protein binding GO:0043413 macromolecule glycosylation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0044849 estrous cycle GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045860 positive regulation of protein kinase activity GO:0045927 positive regulation of growth GO:0045981 positive regulation of nucleotide metabolic process GO:0046068 cGMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0048511 rhythmic process GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050890 cognition GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051402 neuron apoptotic process GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0052652 cyclic purine nucleotide metabolic process GO:0060049 regulation of protein glycosylation GO:0060560 developmental growth involved in morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070085 glycosylation GO:0070997 neuron death GO:0071496 cellular response to external stimulus GO:0072522 purine-containing compound biosynthetic process GO:0090066 regulation of anatomical structure size GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901293 nucleoside phosphate biosynthetic process GO:1903018 regulation of glycoprotein metabolic process GO:1990138 neuron projection extension
Molecular Function	GO:0003682 chromatin binding GO:0005507 copper ion binding GO:0015631 tubulin binding GO:0033218 amide binding GO:0042277 peptide binding GO:0048487 beta-tubulin binding
Cellular Component	GO:0030424 axon GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5629127	c.1419A>G	p.K473K	Substitution - coding silent	Oesophagus
COSM1027977	c.673C>T	p.R225*	Substitution - Nonsense	Endometrium
COSM1327567	c.602G>C	p.G201A	Substitution - Missense	Ovary
COSM1327568	c.1313G>T	p.G438V	Substitution - Missense	Ovary
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Stomach
COSM1244519	c.2872G>C	p.D958H	Substitution - Missense	Stomach
COSM3713324	c.255C>G	p.F85L	Substitution - Missense	Upper_aerodigestive_tract
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Breast
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Breast
COSM4292917	c.2457G>A	p.K819K	Substitution - coding silent	Large_intestine
COSM5641532	c.2855C>A	p.A952E	Substitution - Missense	Oesophagus
COSM5771377	c.2208T>C	p.S736S	Substitution - coding silent	Breast
COSM1615723	c.2291A>G	p.Y764C	Substitution - Missense	Liver
COSM4099359	c.497A>G	p.Y166C	Substitution - Missense	Stomach
COSM1483745	c.2520T>A	p.F840L	Substitution - Missense	Breast
COSM5707484	c.169G>T	p.G57*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1027966	c.2476T>G	p.F826V	Substitution - Missense	Endometrium
COSM4754822	c.2438G>A	p.R813H	Substitution - Missense	Stomach
COSM1681758	c.2747T>G	p.I916S	Substitution - Missense	Large_intestine
COSM4793397	c.1754A>G	p.N585S	Substitution - Missense	Liver
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM673640	c.284A>G	p.N95S	Substitution - Missense	Upper_aerodigestive_tract
COSM1190289	c.3064G>T	p.D1022Y	Substitution - Missense	Lung
COSM3841279	c.2200G>A	p.D734N	Substitution - Missense	Breast
COSM5880459	c.1796A>G	p.E599G	Substitution - Missense	Soft_tissue
COSM4660056	c.191C>T	p.T64M	Substitution - Missense	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Pancreas
COSM4904584	c.1963C>A	p.P655T	Substitution - Missense	Skin
COSM1027970	c.1865C>T	p.T622I	Substitution - Missense	Endometrium
COSM4608929	c.1625C>A	p.P542H	Substitution - Missense	Adrenal_gland
COSM224050	c.915T>A	p.N305K	Substitution - Missense	Skin
COSM1713665	c.799C>T	p.P267S	Substitution - Missense	Skin
COSM4581887	c.3033A>G	p.P1011P	Substitution - coding silent	Bone
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Pancreas
COSM1615724	c.809T>A	p.L270Q	Substitution - Missense	Liver
COSM1483746	c.1743_1744insTTAC	p.H582fs*6	Insertion - Frameshift	Breast
COSM6017935	c.3141G>A	p.W1047*	Substitution - Nonsense	Skin
COSM5553889	c.2890G>C	p.E964Q	Substitution - Missense	Prostate
COSM1027976	c.852A>G	p.P284P	Substitution - coding silent	Endometrium
COSM4660054	c.2715C>T	p.N905N	Substitution - coding silent	Large_intestine
COSM1027975	c.916C>T	p.R306*	Substitution - Nonsense	Large_intestine
COSM1327569	c.1688A>G	p.H563R	Substitution - Missense	Ovary
COSM4458275	c.1079C>T	p.P360L	Substitution - Missense	Skin
COSM4651413	c.2091G>T	p.Q697H	Substitution - Missense	Large_intestine
COSM3841280	c.1948A>T	p.I650F	Substitution - Missense	Breast
COSM3547672	c.213A>G	p.T71T	Substitution - coding silent	Skin
COSM4799615	c.3162T>A	p.D1054E	Substitution - Missense	Liver
COSM4099357	c.736C>T	p.R246C	Substitution - Missense	Stomach
COSM234365	c.2682C>T	p.D894D	Substitution - coding silent	Skin
COSM1027964	c.2818C>A	p.H940N	Substitution - Missense	Endometrium
COSM5557106	c.861C>T	p.I287I	Substitution - coding silent	Prostate
COSM5783963	c.2239G>A	p.E747K	Substitution - Missense	Breast
COSM1683716	c.419_420insCAG	p.S141_T142insS	Insertion - In frame	Ovary
COSM1182085	c.798A>C	p.K266N	Substitution - Missense	Large_intestine
COSM242858	c.649G>A	p.E217K	Substitution - Missense	Prostate
COSM1027967	c.2437C>T	p.R813C	Substitution - Missense	Endometrium
COSM1027977	c.673C>T	p.R225*	Substitution - Nonsense	Endometrium
COSM4819130	c.2189G>T	p.R730L	Substitution - Missense	Cervix
COSM5365896	c.1905A>G	p.I635M	Substitution - Missense	Large_intestine
COSM3972602	c.2814T>C	p.T938T	Substitution - coding silent	Central_nervous_system
COSM79475	c.114T>C	p.F38F	Substitution - coding silent	Ovary
COSM3841278	c.2618A>G	p.D873G	Substitution - Missense	Breast
COSM4660055	c.1981A>G	p.T661A	Substitution - Missense	Large_intestine
COSM1027965	c.2573C>T	p.A858V	Substitution - Missense	Endometrium
COSM444028	c.1041G>A	p.M347I	Substitution - Missense	Breast
COSM1027961	c.3221G>T	p.G1074V	Substitution - Missense	Endometrium
COSM3841281	c.1363C>A	p.L455I	Substitution - Missense	Breast
COSM1684624	c.2247_2249delTGT	p.V751delV	Deletion - In frame	Kidney
COSM444025	c.2901C>T	p.D967D	Substitution - coding silent	Breast
COSM4793397	c.1754A>G	p.N585S	Substitution - Missense	Liver
COSM5936577	c.1516C>A	p.H506N	Substitution - Missense	Skin
COSM5365896	c.1905A>G	p.I635M	Substitution - Missense	Large_intestine
COSM4099358	c.577G>T	p.A193S	Substitution - Missense	Stomach
COSM1027971	c.1594C>T	p.R532W	Substitution - Missense	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM4099360	c.66A>T	p.I22I	Substitution - coding silent	Stomach
COSM1027978	c.638C>T	p.S213L	Substitution - Missense	Endometrium
COSM4472832	c.1809C>T	p.I603I	Substitution - coding silent	Skin
COSM1027969	c.2195T>A	p.L732*	Substitution - Nonsense	Endometrium
COSM4660053	c.3236A>G	p.N1079S	Substitution - Missense	Large_intestine
COSM5773820	c.2464G>A	p.V822M	Substitution - Missense	Breast
COSM1412438	c.1976delA	p.K659fs*17	Deletion - Frameshift	Large_intestine
COSM2762695	c.2235G>C	p.K745N	Substitution - Missense	Large_intestine
COSM4099352	c.2128C>G	p.P710A	Substitution - Missense	Stomach
COSM724207	c.1556C>T	p.S519L	Substitution - Missense	Lung
COSM3841282	c.976C>A	p.H326N	Substitution - Missense	Breast
COSM4099349	c.2716G>A	p.D906N	Substitution - Missense	Stomach
COSM1130607	c.1286C>G	p.A429G	Substitution - Missense	Prostate
COSM73596	c.2068G>A	p.V690I	Substitution - Missense	Ovary
COSM444027	c.2564G>C	p.R855T	Substitution - Missense	Breast
COSM5921658	c.1216C>T	p.Q406*	Substitution - Nonsense	Skin
COSM478295	c.1404A>G	p.E468E	Substitution - coding silent	Kidney
COSM273898	c.1779A>G	p.P593P	Substitution - coding silent	Large_intestine
COSM5916807	c.2897A>T	p.K966I	Substitution - Missense	Skin
COSM724208	c.1709A>G	p.N570S	Substitution - Missense	Lung
COSM2762704	c.1925A>G	p.H642R	Substitution - Missense	Prostate
COSM3911568	c.217C>T	p.P73S	Substitution - Missense	Skin
COSM4935267	c.2685T>G	p.P895P	Substitution - coding silent	Liver
COSM4099355	c.1452A>G	p.I484M	Substitution - Missense	Stomach
COSM3707845	c.332A>G	p.Y111C	Substitution - Missense	Liver
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM4474052	c.1891C>A	p.L631I	Substitution - Missense	Skin
COSM5078461	c.64_65insA	p.I22fs*3	Insertion - Frameshift	Large_intestine
COSM1182083	c.2978C>T	p.P993L	Substitution - Missense	Large_intestine
COSM256058	c.3266A>G	p.H1089R	Substitution - Missense	Large_intestine
COSM6004479	c.1913C>G	p.A638G	Substitution - Missense	Prostate
COSM4453465	c.2996A>C	p.E999A	Substitution - Missense	Skin
COSM4459097	c.1111C>T	p.P371S	Substitution - Missense	Skin
COSM1027978	c.638C>T	p.S213L	Substitution - Missense	Kidney
COSM2762730	c.351C>T	p.D117D	Substitution - coding silent	Pancreas
COSM1615724	c.809T>A	p.L270Q	Substitution - Missense	Liver
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1318827	c.2146A>C	p.K716Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3764890	c.1086A>G	p.Q362Q	Substitution - coding silent	Central_nervous_system
COSM5792500	c.2406C>G	p.S802S	Substitution - coding silent	Breast
COSM1027978	c.638C>T	p.S213L	Substitution - Missense	Large_intestine
COSM1027978	c.638C>T	p.S213L	Substitution - Missense	Endometrium
COSM287472	c.2453A>G	p.Y818C	Substitution - Missense	Large_intestine
COSM444026	c.2860G>C	p.D954H	Substitution - Missense	Skin
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Stomach
COSM5771927	c.1265G>C	p.G422A	Substitution - Missense	Breast
COSM3727905	c.2248G>A	p.V750I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1027972	c.1195_1196insG	p.A399fs*41	Insertion - Frameshift	Endometrium
COSM673640	c.284A>G	p.N95S	Substitution - Missense	Endometrium
COSM3732333	c.1039A>T	p.M347L	Substitution - Missense	Stomach
COSM3547669	c.1867C>T	p.L623F	Substitution - Missense	Skin
COSM4611777	c.3047_3048insA	p.A1017fs*6	Insertion - Frameshift	Large_intestine
COSM1412439	c.64delA	p.I22fs*14	Deletion - Frameshift	Large_intestine
COSM4819014	c.2359G>T	p.E787*	Substitution - Nonsense	Cervix
COSM5028712	c.3209A>C	p.D1070A	Substitution - Missense	Breast
COSM1027962	c.3187G>C	p.E1063Q	Substitution - Missense	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM3991781	c.1021T>A	p.Y341N	Substitution - Missense	Kidney
COSM1027963	c.3009C>T	p.S1003S	Substitution - coding silent	Endometrium
COSM2762713	c.1310delC	p.P437fs*41	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5964066	c.2325C>G	p.F775L	Substitution - Missense	Breast
COSM3713324	c.255C>G	p.F85L	Substitution - Missense	Upper_aerodigestive_tract
COSM1244518	c.2683C>A	p.P895T	Substitution - Missense	Oesophagus
COSM1027963	c.3009C>T	p.S1003S	Substitution - coding silent	Upper_aerodigestive_tract
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM278675	c.3096C>A	p.S1032S	Substitution - coding silent	Large_intestine
COSM4963302	c.3160G>T	p.D1054Y	Substitution - Missense	Pancreas
COSM1027971	c.1594C>T	p.R532W	Substitution - Missense	Stomach
COSM2762682	c.2826T>C	p.T942T	Substitution - coding silent	Large_intestine
COSM3991780	c.1979T>C	p.L660P	Substitution - Missense	Kidney
COSM5957561	c.2107C>T	p.P703S	Substitution - Missense	Thyroid
COSM1182084	c.739A>G	p.I247V	Substitution - Missense	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Pancreas
COSM1681759	c.2456A>C	p.K819T	Substitution - Missense	Ovary
COSM4421380	c.2956G>C	p.D986H	Substitution - Missense	Pleura
COSM444025	c.2901C>T	p.D967D	Substitution - coding silent	Stomach
COSM5464960	c.2808C>T	p.Y936Y	Substitution - coding silent	Large_intestine
COSM1483747	c.260C>G	p.S87C	Substitution - Missense	Breast
COSM3371725	c.2676T>C	p.P892P	Substitution - coding silent	Thyroid
COSM3693575	c.674G>A	p.R225Q	Substitution - Missense	Large_intestine
COSM5562699	c.1769C>T	p.P590L	Substitution - Missense	Prostate
COSM1027975	c.916C>T	p.R306*	Substitution - Nonsense	Cervix
COSM1615723	c.2291A>G	p.Y764C	Substitution - Missense	Liver
COSM1283296	c.2030C>T	p.A677V	Substitution - Missense	Autonomic_ganglia
COSM4853269	c.1612G>T	p.E538*	Substitution - Nonsense	Cervix
COSM4172261	c.158G>A	p.W53*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1027967	c.2437C>T	p.R813C	Substitution - Missense	Endometrium
COSM3547670	c.1749C>T	p.A583A	Substitution - coding silent	Skin
COSM5800215	c.144G>C	p.L48F	Substitution - Missense	Breast
COSM1161390	c.1663C>T	p.Q555*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM173384	c.2990C>A	p.S997Y	Substitution - Missense	Skin
COSM167320	c.1395C>T	p.F465F	Substitution - coding silent	Skin
COSM3668468	c.1401A>T	p.K467N	Substitution - Missense	Liver
COSM1027974	c.1030G>A	p.G344S	Substitution - Missense	Endometrium
COSM3547671	c.493T>A	p.Y165N	Substitution - Missense	Skin
COSM4619128	c.549C>T	p.H183H	Substitution - coding silent	Large_intestine
COSM167320	c.1395C>T	p.F465F	Substitution - coding silent	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Stomach
COSM1641376	c.2321_2322delAT	p.Y774fs*13	Deletion - Frameshift	Stomach
COSM5707483	c.671A>C	p.K224T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Stomach
COSM3720730	c.1490A>G	p.Y497C	Substitution - Missense	Upper_aerodigestive_tract
COSM4099353	c.1831G>A	p.A611T	Substitution - Missense	Stomach
COSM5596226	c.1369C>T	p.P457S	Substitution - Missense	Skin
COSM3707844	c.513T>G	p.T171T	Substitution - coding silent	Liver
COSM3405184	c.2275C>A	p.H759N	Substitution - Missense	Central_nervous_system
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1027967	c.2437C>T	p.R813C	Substitution - Missense	Endometrium
COSM4611777	c.3047_3048insA	p.A1017fs*6	Insertion - Frameshift	Large_intestine
COSM4660054	c.2715C>T	p.N905N	Substitution - coding silent	Large_intestine
COSM3707845	c.332A>G	p.Y111C	Substitution - Missense	Liver
COSM1027968	c.2196A>T	p.L732F	Substitution - Missense	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1190947	c.47delG	p.T18fs*2	Deletion - Frameshift	Lung
COSM4099354	c.1478A>G	p.Y493C	Substitution - Missense	Stomach
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM4754823	c.2071G>T	p.G691*	Substitution - Nonsense	Stomach
COSM4099350	c.2356A>C	p.I786L	Substitution - Missense	Stomach
COSM4099356	c.790C>A	p.R264R	Substitution - coding silent	Stomach
COSM4660054	c.2715C>T	p.N905N	Substitution - coding silent	Biliary_tract
COSM444026	c.2860G>C	p.D954H	Substitution - Missense	Breast
COSM1182082	c.1585G>A	p.A529T	Substitution - Missense	Large_intestine
COSM1027975	c.916C>T	p.R306*	Substitution - Nonsense	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM444024	c.3087G>C	p.K1029N	Substitution - Missense	Breast
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM4611777	c.3047_3048insA	p.A1017fs*6	Insertion - Frameshift	Bone
COSM1169361	c.2405C>T	p.S802F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1660427	c.1700C>T	p.T567I	Substitution - Missense	Kidney
COSM3799657	c.342C>T	p.F114F	Substitution - coding silent	Urinary_tract
COSM4940877	c.1521G>A	p.M507I	Substitution - Missense	Liver
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM4799615	c.3162T>A	p.D1054E	Substitution - Missense	Liver
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Stomach
COSM4611777	c.3047_3048insA	p.A1017fs*6	Insertion - Frameshift	Large_intestine
COSM4767296	c.3205A>T	p.I1069F	Substitution - Missense	Stomach
COSM1169361	c.2405C>T	p.S802F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1027973	c.1062C>T	p.N354N	Substitution - coding silent	Endometrium
COSM5602753	c.1094C>T	p.S365F	Substitution - Missense	Skin
COSM1161390	c.1663C>T	p.Q555*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM395880	c.2028C>T	p.T676T	Substitution - coding silent	Lung
COSM1681758	c.2747T>G	p.I916S	Substitution - Missense	Large_intestine
COSM5707482	c.1529A>G	p.H510R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2762673	c.3166C>T	p.R1056C	Substitution - Missense	Large_intestine
COSM1615722	c.2990C>G	p.S997C	Substitution - Missense	Liver
COSM3668468	c.1401A>T	p.K467N	Substitution - Missense	Liver
COSM4099351	c.2345C>T	p.T782I	Substitution - Missense	Stomach
COSM3707843	c.2038A>G	p.I680V	Substitution - Missense	Liver
COSM395880	c.2028C>T	p.T676T	Substitution - coding silent	Biliary_tract
COSM3707843	c.2038A>G	p.I680V	Substitution - Missense	Liver
COSM5520629	c.63_64insA	p.I22fs*3	Insertion - Frameshift	Biliary_tract
COSM3707844	c.513T>G	p.T171T	Substitution - coding silent	Liver
COSM5612807	c.1584C>T	p.A528A	Substitution - coding silent	Adrenal_gland
COSM167320	c.1395C>T	p.F465F	Substitution - coding silent	Endometrium
COSM1027979	c.528_529delTT	p.Y177fs*1	Deletion - Frameshift	Endometrium
COSM1683716	c.419_420insCAG	p.S141_T142insS	Insertion - In frame	Ovary
COSM273621	c.3096delC	p.Y1033fs*48	Deletion - Frameshift	Large_intestine
COSM1027975	c.916C>T	p.R306*	Substitution - Nonsense	Endometrium
COSM259340	c.1528C>A	p.H510N	Substitution - Missense	Large_intestine
COSM1027980	c.526C>A	p.L176I	Substitution - Missense	Endometrium
COSM1163731	c.3047delA	p.K1016fs*11	Deletion - Frameshift	Large_intestine
COSM3547669	c.1867C>T	p.L623F	Substitution - Missense	Skin
COSM3770844	c.382T>C	p.F128L	Substitution - Missense	Pancreas
COSM5801116	c.3046_3047insA	p.A1017fs*6	Insertion - Frameshift	Breast

> Text Mining based Variations [ TOP ]
There is no record for ADNP.

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9H2P0	348	R	Asymmetric dimethylarginine	-	No	None detected
Q9H2P0	409	S	Phosphoserine	-	No	None detected
Q9H2P0	413	S	Phosphoserine	-	No	None detected
Q9H2P0	608	S	Phosphoserine	-	No	None detected
Q9H2P0	709	S	Phosphoserine	-	No	None detected
Q9H2P0	736	S	Phosphoserine	-	No	None detected
Q9H2P0	738	S	Phosphoserine	-	No	None detected
Q9H2P0	805	S	Phosphoserine	-	No	None detected
Q9H2P0	876	S	Phosphoserine	-	No	None detected
Q9H2P0	878	S	Phosphoserine	-	No	None detected
Q9H2P0	886	S	Phosphoserine	-	No	None detected
Q9H2P0	889	S	Phosphoserine	-	No	None detected
Q9H2P0	921	S	Phosphoserine	-	No	None detected
Q9H2P0	953	S	Phosphoserine	-	No	None detected
Q9H2P0	955	S	Phosphoserine	-	No	None detected
Q9H2P0	1035	K	N6-acetyllysine	-	Yes	p.K1035fs (cancer: STAD)
Q9H2P0	1042	K	N6-acetyllysine	-	No	None detected
Q9H2P0	1071	S	Phosphoserine	-	No	None detected

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.704	6.85	0.221	0.203	NS
BRCA	Breast invasive carcinoma	112	1100	7.082	7.485	0.392	1.3e-10	NS
CESC	Cervical and endocervical cancers	3	306	6.741	6.903	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.33	6.962	0.662	4.25e-14	Over
ESCA	Esophageal carcinoma	11	185	7.081	7.311	0.244	0.171	NS
GBM	Glioblastoma multiforme	5	166	6.759	6.854	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.525	6.605	0.109	0.363	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.795	6.658	-0.157	0.00776	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.602	6.423	-0.199	0.073	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.612	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.908	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.146	5.357	0.175	0.125	NS
LUAD	Lung adenocarcinoma	59	517	6.414	6.644	0.306	3.67e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	6.352	7.02	0.718	3.88e-25	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.29	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.354	6.411	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.182	6.418	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.833	6.893	0.036	0.702	NS
READ	Rectum adenocarcinoma	10	167	6.312	7.197	0.832	2.25e-05	Over
SARC	Sarcoma	2	263	5.925	6.53	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.673	6.978	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.369	7.037	0.616	3.82e-10	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.357	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.937	6.709	-0.211	0.00121	NS
THYM	Thymoma	2	120	7.071	6.942	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.804	6.727	-0.096	0.418	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	11.5
Autonomic ganglia	CHP212	10.6
Autonomic ganglia	IMR32	11.2
Autonomic ganglia	KELLY	10.8
Autonomic ganglia	KPNRTBM1	10.9
Autonomic ganglia	KPNSI9S	10.8
Autonomic ganglia	KPNYN	11.2
Autonomic ganglia	MHHNB11	11.4
Autonomic ganglia	NB1	10.9
Autonomic ganglia	NH6	11
Autonomic ganglia	SHSY5Y	10.7
Autonomic ganglia	SIMA	10.9
Autonomic ganglia	SKNAS	10.3
Autonomic ganglia	SKNBE2	11.2
Autonomic ganglia	SKNDZ	11.3
Autonomic ganglia	SKNFI	10.1
Autonomic ganglia	SKNSH	10.2
Biliary tract	HUCCT1	9.8
Biliary tract	HUH28	10.3
Biliary tract	SNU1079	10.7
Biliary tract	SNU1196	11.1
Biliary tract	SNU245	10.3
Biliary tract	SNU308	10.8
Biliary tract	SNU478	10.1
Bone	143B	10.5
Bone	A673	10.9
Bone	CADOES1	11.2
Bone	CAL78	10
Bone	G292CLONEA141B1	10.8
Bone	HOS	10.6
Bone	HS706T	9.8
Bone	HS737T	9.8
Bone	HS819T	9.5
Bone	HS821T	9.8
Bone	HS822T	9.5
Bone	HS863T	9.7
Bone	HS870T	9.4
Bone	HS888T	10.2
Bone	MG63	10.1
Bone	MHHES1	10.5
Bone	OUMS27	10.8
Bone	RDES	11
Bone	SJSA1	9.6
Bone	SKES1	10.9
Bone	SKNMC	10.7
Bone	SW1353	10.1
Bone	T173	9.4
Bone	TC71	10.3
Bone	U2OS	11.4
Breast	AU565	11
Breast	BT20	10.9
Breast	BT474	11.4
Breast	BT483	11.7
Breast	BT549	9.9
Breast	CAL120	10.4
Breast	CAL148	11.6
Breast	CAL51	11.3
Breast	CAL851	9.5
Breast	CAMA1	11
Breast	DU4475	10.5
Breast	EFM192A	10.6
Breast	EFM19	10.4
Breast	EVSAT	10.5
Breast	HCC1143	10.2
Breast	HCC1187	10.7
Breast	HCC1395	10.5
Breast	HCC1419	12
Breast	HCC1428	10.7
Breast	HCC1500	11.6
Breast	HCC1569	10.7
Breast	HCC1599	10.6
Breast	HCC1806	10.9
Breast	HCC1937	10.2
Breast	HCC1954	10.6
Breast	HCC202	11.1
Breast	HCC2157	11
Breast	HCC2218	10.5
Breast	HCC38	10.5
Breast	HCC70	10.8
Breast	HDQP1	10.3
Breast	HMC18	10.1
Breast	HS274T	9.8
Breast	HS281T	9.9
Breast	HS343T	9.8
Breast	HS578T	9.9
Breast	HS606T	9.7
Breast	HS739T	9.7
Breast	HS742T	9.2
Breast	JIMT1	10.9
Breast	KPL1	11.4
Breast	MCF7	11.1
Breast	MDAMB134VI	11.3
Breast	MDAMB157	11.1
Breast	MDAMB175VII	10.9
Breast	MDAMB231	9.6
Breast	MDAMB361	11.2
Breast	MDAMB415	10.2
Breast	MDAMB436	10.4
Breast	MDAMB453	11
Breast	MDAMB468	10.4
Breast	SKBR3	11.4
Breast	T47D	10.7
Breast	UACC812	11
Breast	UACC893	10.6
Breast	YMB1	10.3
Breast	ZR751	10.4
Breast	ZR7530	10.9
Central nervous system	1321N1	11.4
Central nervous system	42MGBA	10.4
Central nervous system	8MGBA	10.1
Central nervous system	A172	10.2
Central nervous system	AM38	9.7
Central nervous system	BECKER	10.6
Central nervous system	CAS1	10.7
Central nervous system	CCFSTTG1	10.4
Central nervous system	D283MED	10.8
Central nervous system	D341MED	10.7
Central nervous system	DAOY	10.3
Central nervous system	DBTRG05MG	10
Central nervous system	DKMG	10.1
Central nervous system	GAMG	10
Central nervous system	GB1	10.4
Central nervous system	GI1	10.7
Central nervous system	GMS10	10.3
Central nervous system	GOS3	10
Central nervous system	H4	10
Central nervous system	HS683	10.4
Central nervous system	KALS1	10.1
Central nervous system	KG1C	10.8
Central nervous system	KNS42	10.5
Central nervous system	KNS60	10.1
Central nervous system	KNS81	9.7
Central nervous system	KS1	9.8
Central nervous system	LN18	10.3
Central nervous system	LN229	10.1
Central nervous system	M059K	9.6
Central nervous system	MOGGCCM	10.4
Central nervous system	MOGGUVW	10.3
Central nervous system	NMCG1	9.9
Central nervous system	ONS76	11
Central nervous system	SF126	10.4
Central nervous system	SF295	9.6
Central nervous system	SNB19	10.2
Central nervous system	SNU1105	10.4
Central nervous system	SNU201	10.5
Central nervous system	SNU466	10.1
Central nervous system	SNU489	10.2
Central nervous system	SNU626	10.2
Central nervous system	SNU738	11
Central nervous system	SW1088	10.2
Central nervous system	SW1783	9.7
Central nervous system	T98G	9.7
Central nervous system	TM31	9.8
Central nervous system	U118MG	10.5
Central nervous system	U138MG	10.5
Central nervous system	U251MG	10.3
Central nervous system	U87MG	9.5
Central nervous system	YH13	10.1
Central nervous system	YKG1	10.8
Endometrium	AN3CA	10.4
Endometrium	COLO684	11.2
Endometrium	EFE184	10.6
Endometrium	EN	10.5
Endometrium	ESS1	9.6
Endometrium	HEC108	10.8
Endometrium	HEC151	10
Endometrium	HEC1A	10
Endometrium	HEC1B	10.8
Endometrium	HEC251	10.5
Endometrium	HEC265	9.8
Endometrium	HEC50B	10.5
Endometrium	HEC59	10.6
Endometrium	HEC6	10.6
Endometrium	ISHIKAWAHERAKLIO02ER	10.7
Endometrium	JHUEM1	10.2
Endometrium	JHUEM2	10.6
Endometrium	JHUEM3	10
Endometrium	KLE	9.9
Endometrium	MFE280	10.8
Endometrium	MFE296	10.3
Endometrium	MFE319	9.7
Endometrium	RL952	10.2
Endometrium	SNGM	10.3
Endometrium	SNU1077	10.4
Endometrium	SNU685	10.4
Endometrium	TEN	11.2
Haematopoietic and lymphoid	697	11.1
Haematopoietic and lymphoid	A3KAW	10.2
Haematopoietic and lymphoid	A4FUK	10.1
Haematopoietic and lymphoid	ALLSIL	10.9
Haematopoietic and lymphoid	AML193	9.9
Haematopoietic and lymphoid	AMO1	10.6
Haematopoietic and lymphoid	BCP1	10
Haematopoietic and lymphoid	BDCM	10.3
Haematopoietic and lymphoid	BL41	11.2
Haematopoietic and lymphoid	BL70	10.8
Haematopoietic and lymphoid	BV173	11
Haematopoietic and lymphoid	CA46	11
Haematopoietic and lymphoid	CI1	10.8
Haematopoietic and lymphoid	CMK115	10.9
Haematopoietic and lymphoid	CMK86	10.5
Haematopoietic and lymphoid	CMK	10.7
Haematopoietic and lymphoid	CMLT1	10.7
Haematopoietic and lymphoid	COLO775	9.7
Haematopoietic and lymphoid	DAUDI	10.9
Haematopoietic and lymphoid	DB	11
Haematopoietic and lymphoid	DEL	10.3
Haematopoietic and lymphoid	DND41	11.1
Haematopoietic and lymphoid	DOHH2	11
Haematopoietic and lymphoid	EB1	10.9
Haematopoietic and lymphoid	EB2	10.9
Haematopoietic and lymphoid	EHEB	10.5
Haematopoietic and lymphoid	EJM	10.9
Haematopoietic and lymphoid	EM2	10.7
Haematopoietic and lymphoid	EOL1	10.9
Haematopoietic and lymphoid	F36P	9.7
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	10.5
Haematopoietic and lymphoid	GRANTA519	10.7
Haematopoietic and lymphoid	HDLM2	10.1
Haematopoietic and lymphoid	HDMYZ	9.9
Haematopoietic and lymphoid	HEL9217	9.8
Haematopoietic and lymphoid	HEL	9.9
Haematopoietic and lymphoid	HH	10.1
Haematopoietic and lymphoid	HL60	10.5
Haematopoietic and lymphoid	HPBALL	11.3
Haematopoietic and lymphoid	HS604T	9.9
Haematopoietic and lymphoid	HS611T	10.4
Haematopoietic and lymphoid	HS616T	9.6
Haematopoietic and lymphoid	HS751T	9.8
Haematopoietic and lymphoid	HT	11
Haematopoietic and lymphoid	HTK	10.1
Haematopoietic and lymphoid	HUNS1	10.3
Haematopoietic and lymphoid	HUT102	10.6
Haematopoietic and lymphoid	HUT78	10.6
Haematopoietic and lymphoid	JEKO1	11.4
Haematopoietic and lymphoid	JK1	10.5
Haematopoietic and lymphoid	JM1	11.1
Haematopoietic and lymphoid	JURKAT	10.8
Haematopoietic and lymphoid	JURLMK1	10.8
Haematopoietic and lymphoid	JVM2	10.5
Haematopoietic and lymphoid	JVM3	10.7
Haematopoietic and lymphoid	K562	9.7
Haematopoietic and lymphoid	KARPAS299	10.3
Haematopoietic and lymphoid	KARPAS422	10.7
Haematopoietic and lymphoid	KARPAS620	10.8
Haematopoietic and lymphoid	KASUMI1	10.8
Haematopoietic and lymphoid	KASUMI2	11.3
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	10.3
Haematopoietic and lymphoid	KE37	11.1
Haematopoietic and lymphoid	KE97	10.1
Haematopoietic and lymphoid	KG1	10.6
Haematopoietic and lymphoid	KHM1B	10.6
Haematopoietic and lymphoid	KIJK	10.5
Haematopoietic and lymphoid	KMH2	10.1
Haematopoietic and lymphoid	KMM1	10.1
Haematopoietic and lymphoid	KMS11	11.2
Haematopoietic and lymphoid	KMS12BM	10.9
Haematopoietic and lymphoid	KMS18	10.6
Haematopoietic and lymphoid	KMS20	10.8
Haematopoietic and lymphoid	KMS21BM	10.1
Haematopoietic and lymphoid	KMS26	10.1
Haematopoietic and lymphoid	KMS27	9.8
Haematopoietic and lymphoid	KMS28BM	10.8
Haematopoietic and lymphoid	KMS34	10.6
Haematopoietic and lymphoid	KO52	10.5
Haematopoietic and lymphoid	KOPN8	11.1
Haematopoietic and lymphoid	KU812	10.5
Haematopoietic and lymphoid	KYO1	10.8
Haematopoietic and lymphoid	L1236	9.5
Haematopoietic and lymphoid	L363	10.5
Haematopoietic and lymphoid	L428	10.3
Haematopoietic and lymphoid	L540	10
Haematopoietic and lymphoid	LAMA84	10.2
Haematopoietic and lymphoid	LOUCY	10.5
Haematopoietic and lymphoid	LP1	11.3
Haematopoietic and lymphoid	M07E	10.9
Haematopoietic and lymphoid	MC116	10.6
Haematopoietic and lymphoid	ME1	10.9
Haematopoietic and lymphoid	MEC1	10.9
Haematopoietic and lymphoid	MEC2	11.1
Haematopoietic and lymphoid	MEG01	10.5
Haematopoietic and lymphoid	MHHCALL2	11.2
Haematopoietic and lymphoid	MHHCALL3	11.3
Haematopoietic and lymphoid	MHHCALL4	11.3
Haematopoietic and lymphoid	MINO	11.2
Haematopoietic and lymphoid	MJ	10.5
Haematopoietic and lymphoid	MM1S	10.1
Haematopoietic and lymphoid	MOLM13	10.1
Haematopoietic and lymphoid	MOLM16	11.2
Haematopoietic and lymphoid	MOLM6	10.3
Haematopoietic and lymphoid	MOLP2	10.4
Haematopoietic and lymphoid	MOLP8	10.5
Haematopoietic and lymphoid	MOLT13	11
Haematopoietic and lymphoid	MOLT16	10.6
Haematopoietic and lymphoid	MOLT4	10.4
Haematopoietic and lymphoid	MONOMAC1	10.6
Haematopoietic and lymphoid	MONOMAC6	10.8
Haematopoietic and lymphoid	MOTN1	10.1
Haematopoietic and lymphoid	MUTZ5	11.4
Haematopoietic and lymphoid	MV411	10.8
Haematopoietic and lymphoid	NALM19	11.2
Haematopoietic and lymphoid	NALM1	11.2
Haematopoietic and lymphoid	NALM6	11
Haematopoietic and lymphoid	NAMALWA	11.1
Haematopoietic and lymphoid	NB4	10.7
Haematopoietic and lymphoid	NCIH929	10.1
Haematopoietic and lymphoid	NCO2	10.5
Haematopoietic and lymphoid	NOMO1	10.7
Haematopoietic and lymphoid	NUDHL1	10.8
Haematopoietic and lymphoid	NUDUL1	11
Haematopoietic and lymphoid	OCIAML2	10.7
Haematopoietic and lymphoid	OCIAML3	11.2
Haematopoietic and lymphoid	OCIAML5	10.5
Haematopoietic and lymphoid	OCILY10	10.4
Haematopoietic and lymphoid	OCILY19	11.5
Haematopoietic and lymphoid	OCILY3	11.1
Haematopoietic and lymphoid	OCIM1	10.1
Haematopoietic and lymphoid	OPM2	10.8
Haematopoietic and lymphoid	P12ICHIKAWA	10.6
Haematopoietic and lymphoid	P31FUJ	10.4
Haematopoietic and lymphoid	P3HR1	10.9
Haematopoietic and lymphoid	PCM6	10.1
Haematopoietic and lymphoid	PEER	10.9
Haematopoietic and lymphoid	PF382	10.9
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	10.5
Haematopoietic and lymphoid	RAJI	10.5
Haematopoietic and lymphoid	RCHACV	11.5
Haematopoietic and lymphoid	REC1	11
Haematopoietic and lymphoid	REH	10.8
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	10.4
Haematopoietic and lymphoid	RPMI8226	10.6
Haematopoietic and lymphoid	RPMI8402	11.4
Haematopoietic and lymphoid	RS411	11.1
Haematopoietic and lymphoid	SEM	11
Haematopoietic and lymphoid	SET2	10.7
Haematopoietic and lymphoid	SIGM5	10.4
Haematopoietic and lymphoid	SKM1	10.4
Haematopoietic and lymphoid	SKMM2	10.4
Haematopoietic and lymphoid	SR786	9.5
Haematopoietic and lymphoid	ST486	10.3
Haematopoietic and lymphoid	SUDHL10	10.9
Haematopoietic and lymphoid	SUDHL1	10.8
Haematopoietic and lymphoid	SUDHL4	11
Haematopoietic and lymphoid	SUDHL5	10.7
Haematopoietic and lymphoid	SUDHL6	10.7
Haematopoietic and lymphoid	SUDHL8	11.3
Haematopoietic and lymphoid	SUPB15	10.5
Haematopoietic and lymphoid	SUPHD1	10.5
Haematopoietic and lymphoid	SUPM2	10
Haematopoietic and lymphoid	SUPT11	10.9
Haematopoietic and lymphoid	SUPT1	10.7
Haematopoietic and lymphoid	TALL1	10.6
Haematopoietic and lymphoid	TF1	10.6
Haematopoietic and lymphoid	THP1	10.6
Haematopoietic and lymphoid	TO175T	9.8
Haematopoietic and lymphoid	TOLEDO	11
Haematopoietic and lymphoid	U266B1	10.2
Haematopoietic and lymphoid	U937	10.4
Haematopoietic and lymphoid	UT7	11
Haematopoietic and lymphoid	WSUDLCL2	11.1
Kidney	769P	9.7
Kidney	786O	9.7
Kidney	A498	10.1
Kidney	A704	9.2
Kidney	ACHN	9.9
Kidney	BFTC909	10.1
Kidney	CAKI1	10
Kidney	CAKI2	10.2
Kidney	CAL54	10.9
Kidney	KMRC1	10.1
Kidney	KMRC20	10.2
Kidney	KMRC2	9.9
Kidney	KMRC3	10
Kidney	OSRC2	10.5
Kidney	RCC10RGB	10.4
Kidney	SNU1272	10
Kidney	SNU349	9.6
Kidney	TUHR10TKB	10
Kidney	TUHR14TKB	10.4
Kidney	TUHR4TKB	10
Kidney	VMRCRCW	10.6
Kidney	VMRCRCZ	10.4
Large intestine	C2BBE1	11.2
Large intestine	CCK81	10.2
Large intestine	CL11	10.8
Large intestine	CL14	11.4
Large intestine	CL34	10.5
Large intestine	CL40	10.5
Large intestine	COLO205	10.2
Large intestine	COLO320	11.4
Large intestine	COLO678	11.3
Large intestine	CW2	10.2
Large intestine	DLD1	9.7
Large intestine	GP2D	10.5
Large intestine	HCC56	10.8
Large intestine	HCT116	10.4
Large intestine	HCT15	9.9
Large intestine	HS675T	9.8
Large intestine	HS698T	9.9
Large intestine	HT115	10.5
Large intestine	HT29	10.9
Large intestine	HT55	11.1
Large intestine	KM12	10.6
Large intestine	LOVO	9.9
Large intestine	LS1034	11.4
Large intestine	LS123	10.5
Large intestine	LS180	10
Large intestine	LS411N	10.4
Large intestine	LS513	9.8
Large intestine	MDST8	10.7
Large intestine	NCIH508	10.6
Large intestine	NCIH716	10.8
Large intestine	NCIH747	10.9
Large intestine	OUMS23	10.8
Large intestine	RCM1	11.2
Large intestine	RKO	10.6
Large intestine	SKCO1	10.4
Large intestine	SNU1040	10.6
Large intestine	SNU1197	10.3
Large intestine	SNU175	10.7
Large intestine	SNU283	10.6
Large intestine	SNU407	10
Large intestine	SNU503	10.6
Large intestine	SNU61	11
Large intestine	SNU81	10.8
Large intestine	SNUC1	10.7
Large intestine	SNUC2A	10.9
Large intestine	SNUC4	10.4
Large intestine	SNUC5	11
Large intestine	SW1116	10.6
Large intestine	SW1417	11.3
Large intestine	SW1463	10.5
Large intestine	SW403	10.4
Large intestine	SW480	10.3
Large intestine	SW48	10.8
Large intestine	SW620	10.9
Large intestine	SW837	11.1
Large intestine	SW948	11.1
Large intestine	T84	10.2
Liver	ALEXANDERCELLS	9.5
Liver	C3A	10
Liver	HEP3B217	11
Liver	HEPG2	10
Liver	HLE	10.7
Liver	HLF	10.6
Liver	HUH1	10.6
Liver	HUH6	10.2
Liver	HUH7	9.6
Liver	JHH1	10.6
Liver	JHH2	10.6
Liver	JHH4	10.6
Liver	JHH5	10.4
Liver	JHH6	10
Liver	JHH7	10.1
Liver	LI7	10.4
Liver	PLCPRF5	9.6
Liver	SKHEP1	10.2
Liver	SNU182	10.4
Liver	SNU387	10.2
Liver	SNU398	10.6
Liver	SNU423	10.3
Liver	SNU449	10.7
Liver	SNU475	10.4
Liver	SNU761	10.3
Liver	SNU878	10.1
Liver	SNU886	10.2
Lung	A549	10
Lung	ABC1	10.2
Lung	BEN	10.5
Lung	CAL12T	10.2
Lung	CALU1	10.2
Lung	CALU3	10.4
Lung	CALU6	10.7
Lung	CHAGOK1	11.2
Lung	COLO668	10
Lung	COLO699	10.8
Lung	CORL105	10.5
Lung	CORL23	10.6
Lung	CORL24	11.4
Lung	CORL279	11.4
Lung	CORL311	11.4
Lung	CORL47	10.5
Lung	CORL51	11.1
Lung	CORL88	10.9
Lung	CORL95	10.6
Lung	CPCN	11.1
Lung	DMS114	11.8
Lung	DMS153	11
Lung	DMS273	10.7
Lung	DMS454	10.4
Lung	DMS53	9.8
Lung	DMS79	10.8
Lung	DV90	9.6
Lung	EBC1	10.1
Lung	EPLC272H	10.1
Lung	HARA	9.9
Lung	HCC1171	11.1
Lung	HCC1195	10.4
Lung	HCC15	9.1
Lung	HCC2279	10
Lung	HCC2935	10.8
Lung	HCC33	11
Lung	HCC366	10.2
Lung	HCC4006	9.7
Lung	HCC44	9.6
Lung	HCC78	9.7
Lung	HCC827	10.2
Lung	HCC95	10.4
Lung	HLC1	10.4
Lung	HLFA	9.5
Lung	HS229T	10.1
Lung	HS618T	9.7
Lung	IALM	9.9
Lung	KNS62	10.6
Lung	LC1F	10.8
Lung	LC1SQSF	10.8
Lung	LCLC103H	9.6
Lung	LCLC97TM1	10.3
Lung	LK2	10.3
Lung	LOUNH91	10
Lung	LU65	10
Lung	LU99	10.3
Lung	LUDLU1	10.7
Lung	LXF289	10.6
Lung	MORCPR	10.7
Lung	NCIH1048	10.9
Lung	NCIH1092	11
Lung	NCIH1105	11.6
Lung	NCIH1155	10.2
Lung	NCIH1184	10.8
Lung	NCIH1299	9.8
Lung	NCIH1339	10.4
Lung	NCIH1341	11
Lung	NCIH1355	10
Lung	NCIH1373	9.9
Lung	NCIH1385	11
Lung	NCIH1395	9.9
Lung	NCIH1435	10.2
Lung	NCIH1436	10.7
Lung	NCIH1437	9.7
Lung	NCIH146	10.7
Lung	NCIH1563	10.6
Lung	NCIH1568	10.4
Lung	NCIH1573	10.4
Lung	NCIH1581	10.4
Lung	NCIH1618	11.2
Lung	NCIH1623	10.6
Lung	NCIH1648	10.5
Lung	NCIH1650	11
Lung	NCIH1651	10.4
Lung	NCIH1666	10.8
Lung	NCIH1693	10
Lung	NCIH1694	10.3
Lung	NCIH1703	9.9
Lung	NCIH1734	10
Lung	NCIH1755	10.5
Lung	NCIH1781	10.7
Lung	NCIH1792	10.1
Lung	NCIH1793	10.4
Lung	NCIH1836	11
Lung	NCIH1838	10.3
Lung	NCIH1869	9.7
Lung	NCIH1876	11.1
Lung	NCIH1915	9.7
Lung	NCIH1930	10.9
Lung	NCIH1944	9.8
Lung	NCIH1963	11
Lung	NCIH196	9.6
Lung	NCIH1975	10.3
Lung	NCIH2009	10.2
Lung	NCIH2023	10.3
Lung	NCIH2029	11
Lung	NCIH2030	10.2
Lung	NCIH2066	10.9
Lung	NCIH2081	11.2
Lung	NCIH2085	10.3
Lung	NCIH2087	9.6
Lung	NCIH209	10.6
Lung	NCIH2106	10.8
Lung	NCIH2110	10.6
Lung	NCIH211	10.6
Lung	NCIH2122	10.1
Lung	NCIH2126	10.1
Lung	NCIH2141	11.1
Lung	NCIH2170	10.8
Lung	NCIH2171	10.7
Lung	NCIH2172	11
Lung	NCIH2196	11
Lung	NCIH2227	11
Lung	NCIH2228	9.7
Lung	NCIH226	9.9
Lung	NCIH2286	10.5
Lung	NCIH2291	10.2
Lung	NCIH2342	10.4
Lung	NCIH2347	10.2
Lung	NCIH23	10.5
Lung	NCIH2405	10.4
Lung	NCIH2444	9.9
Lung	NCIH292	10.8
Lung	NCIH322	10.4
Lung	NCIH3255	10.8
Lung	NCIH358	10.8
Lung	NCIH441	9.8
Lung	NCIH446	10.5
Lung	NCIH460	9.9
Lung	NCIH510	10.8
Lung	NCIH520	9.7
Lung	NCIH522	11
Lung	NCIH524	10.7
Lung	NCIH526	10.9
Lung	NCIH596	10.9
Lung	NCIH647	9.9
Lung	NCIH650	9.4
Lung	NCIH661	10.5
Lung	NCIH69	9.6
Lung	NCIH727	10.9
Lung	NCIH810	11
Lung	NCIH82	11
Lung	NCIH838	10.5
Lung	NCIH841	10.6
Lung	NCIH854	11.6
Lung	NCIH889	10.8
Lung	PC14	9.9
Lung	RERFLCAD1	10.5
Lung	RERFLCAD2	9.8
Lung	RERFLCAI	10
Lung	RERFLCKJ	10.1
Lung	RERFLCMS	9.8
Lung	RERFLCSQ1	10.2
Lung	SBC5	10.1
Lung	SCLC21H	11.3
Lung	SHP77	10.2
Lung	SKLU1	9.6
Lung	SKMES1	9.4
Lung	SQ1	10.1
Lung	SW1271	10.2
Lung	SW1573	10.5
Lung	SW900	10.2
Lung	VMRCLCD	10.4
Lung	VMRCLCP	11.1
Oesophagus	COLO680N	10.4
Oesophagus	ECGI10	10.3
Oesophagus	KYSE140	9.9
Oesophagus	KYSE150	10.7
Oesophagus	KYSE180	10.6
Oesophagus	KYSE270	10.1
Oesophagus	KYSE30	9.9
Oesophagus	KYSE410	10.6
Oesophagus	KYSE450	10.4
Oesophagus	KYSE510	10.1
Oesophagus	KYSE520	10.6
Oesophagus	KYSE70	10.4
Oesophagus	OE19	10
Oesophagus	OE33	10.7
Oesophagus	TE10	10.9
Oesophagus	TE11	10.2
Oesophagus	TE14	10.5
Oesophagus	TE15	10
Oesophagus	TE1	10.3
Oesophagus	TE4	10.3
Oesophagus	TE5	10.5
Oesophagus	TE6	10.7
Oesophagus	TE8	11.5
Oesophagus	TE9	10.4
Oesophagus	TT	10.6
Ovary	59M	9.8
Ovary	A2780	10.4
Ovary	CAOV3	10.1
Ovary	CAOV4	10.8
Ovary	COLO704	11.1
Ovary	COV318	11.1
Ovary	COV362	10.7
Ovary	COV434	10.6
Ovary	COV504	10.2
Ovary	COV644	9.8
Ovary	EFO21	10.7
Ovary	EFO27	10.4
Ovary	ES2	10.1
Ovary	FUOV1	11
Ovary	HEYA8	9.8
Ovary	HS571T	9.4
Ovary	IGROV1	10.7
Ovary	JHOC5	9.9
Ovary	JHOM1	10.3
Ovary	JHOM2B	11.4
Ovary	JHOS2	9.5
Ovary	JHOS4	10.6
Ovary	KURAMOCHI	11.2
Ovary	MCAS	10.7
Ovary	NIHOVCAR3	10.7
Ovary	OAW28	10.2
Ovary	OAW42	10.9
Ovary	OC314	10.3
Ovary	OC316	10.3
Ovary	ONCODG1	10.9
Ovary	OV56	9.8
Ovary	OV7	10.1
Ovary	OV90	9.8
Ovary	OVCAR4	10
Ovary	OVCAR8	10.3
Ovary	OVISE	9.4
Ovary	OVK18	10.5
Ovary	OVKATE	11
Ovary	OVMANA	10.5
Ovary	OVSAHO	10.7
Ovary	OVTOKO	9.4
Ovary	RMGI	9.1
Ovary	RMUGS	10.1
Ovary	SKOV3	10.4
Ovary	SNU119	10.5
Ovary	SNU840	10.4
Ovary	SNU8	10.5
Ovary	TOV112D	10
Ovary	TOV21G	9.8
Ovary	TYKNU	9.6
Pancreas	ASPC1	10
Pancreas	BXPC3	10.6
Pancreas	CAPAN1	10.4
Pancreas	CAPAN2	10.1
Pancreas	CFPAC1	10.4
Pancreas	DANG	10.5
Pancreas	HPAC	10.8
Pancreas	HPAFII	10.8
Pancreas	HS766T	10.4
Pancreas	HUPT3	9.8
Pancreas	HUPT4	10.6
Pancreas	KCIMOH1	10.3
Pancreas	KLM1	10.1
Pancreas	KP2	10.2
Pancreas	KP3	9.8
Pancreas	KP4	10.6
Pancreas	L33	10.9
Pancreas	MIAPACA2	10
Pancreas	PANC0203	10.6
Pancreas	PANC0213	10.5
Pancreas	PANC0327	9.8
Pancreas	PANC0403	10.4
Pancreas	PANC0504	10.2
Pancreas	PANC0813	10.4
Pancreas	PANC1005	10
Pancreas	PANC1	10.2
Pancreas	PATU8902	10
Pancreas	PATU8988S	10.7
Pancreas	PATU8988T	10.4
Pancreas	PK1	10.5
Pancreas	PK45H	10.1
Pancreas	PK59	11.1
Pancreas	PL45	10.4
Pancreas	PSN1	10.5
Pancreas	QGP1	10.1
Pancreas	SNU213	10.4
Pancreas	SNU324	10.7
Pancreas	SNU410	10.8
Pancreas	SU8686	10.4
Pancreas	SUIT2	10.1
Pancreas	SW1990	10.1
Pancreas	T3M4	10.1
Pancreas	TCCPAN2	10.7
Pancreas	YAPC	10.8
Pleura	ACCMESO1	9.6
Pleura	DM3	9.5
Pleura	ISTMES1	10.3
Pleura	ISTMES2	10.1
Pleura	JL1	10.9
Pleura	MPP89	9.9
Pleura	MSTO211H	10
Pleura	NCIH2052	10.6
Pleura	NCIH2452	10.3
Pleura	NCIH28	10.7
Prostate	22RV1	9.8
Prostate	DU145	9.7
Prostate	LNCAPCLONEFGC	10.5
Prostate	MDAPCA2B	10.4
Prostate	NCIH660	10.4
Prostate	PC3	9.8
Prostate	VCAP	10.8
Salivary gland	A253	10.8
Salivary gland	YD15	10.4
Skin	A101D	10.4
Skin	A2058	9.9
Skin	A375	10.5
Skin	C32	10.5
Skin	CHL1	10.7
Skin	CJM	10.4
Skin	COLO679	10.3
Skin	COLO741	10.2
Skin	COLO783	10.7
Skin	COLO792	10
Skin	COLO800	10.3
Skin	COLO818	10.4
Skin	COLO829	10.1
Skin	COLO849	10.8
Skin	G361	10.6
Skin	GRM	10.7
Skin	HMCB	10.4
Skin	HS294T	10.4
Skin	HS600T	9.7
Skin	HS688AT	9.7
Skin	HS695T	10.4
Skin	HS839T	9.9
Skin	HS852T	10.4
Skin	HS895T	9.2
Skin	HS934T	9.8
Skin	HS936T	10.2
Skin	HS939T	10
Skin	HS940T	9.8
Skin	HS944T	10
Skin	HT144	10.8
Skin	IGR1	10
Skin	IGR37	10.5
Skin	IGR39	10.8
Skin	IPC298	10
Skin	K029AX	10
Skin	LOXIMVI	10.6
Skin	MALME3M	10.2
Skin	MDAMB435S	10.7
Skin	MELHO	10.4
Skin	MELJUSO	10.2
Skin	MEWO	11
Skin	RPMI7951	11
Skin	RVH421	10.7
Skin	SH4	10.6
Skin	SKMEL1	10.5
Skin	SKMEL24	9.8
Skin	SKMEL28	10.9
Skin	SKMEL2	10.3
Skin	SKMEL30	10.1
Skin	SKMEL31	9.7
Skin	SKMEL3	10.6
Skin	SKMEL5	10.4
Skin	UACC257	10.3
Skin	UACC62	10.3
Skin	WM115	9.7
Skin	WM1799	10.5
Skin	WM2664	9.9
Skin	WM793	10.5
Skin	WM88	10.3
Skin	WM983B	10.8
Small intestine	HUTU80	10.8
Soft tissue	A204	10
Soft tissue	G401	10.5
Soft tissue	G402	10.1
Soft tissue	GCT	10.7
Soft tissue	HS729	10.6
Soft tissue	HT1080	9.9
Soft tissue	KYM1	10.5
Soft tissue	MESSA	10.6
Soft tissue	RD	10.8
Soft tissue	RH30	9.7
Soft tissue	RH41	11.6
Soft tissue	RKN	10.4
Soft tissue	S117	10.6
Soft tissue	SJRH30	11.1
Soft tissue	SKLMS1	10.5
Soft tissue	SKUT1	10.6
Soft tissue	TE125T	9.4
Soft tissue	TE159T	9.7
Soft tissue	TE441T	11.2
Soft tissue	TE617T	10.4
Stomach	2313287	11.2
Stomach	AGS	10.7
Stomach	AZ521	10.7
Stomach	ECC10	11.6
Stomach	ECC12	11.6
Stomach	FU97	10.2
Stomach	GCIY	10
Stomach	GSS	11.5
Stomach	GSU	10.1
Stomach	HGC27	10
Stomach	HS746T	10.2
Stomach	HUG1N	10.2
Stomach	IM95	10.2
Stomach	KATOIII	10.5
Stomach	KE39	10.5
Stomach	LMSU	9.7
Stomach	MKN1	10.7
Stomach	MKN45	10.8
Stomach	MKN74	10.9
Stomach	MKN7	10.5
Stomach	NCCSTCK140	11
Stomach	NCIN87	10.2
Stomach	NUGC2	11.1
Stomach	NUGC3	10.1
Stomach	NUGC4	10.4
Stomach	OCUM1	10.4
Stomach	RERFGC1B	11.1
Stomach	SH10TC	10.2
Stomach	SNU16	11
Stomach	SNU1	10.8
Stomach	SNU216	11.4
Stomach	SNU520	10.4
Stomach	SNU5	10.1
Stomach	SNU601	10.7
Stomach	SNU620	10.8
Stomach	SNU668	10.3
Stomach	SNU719	11.2
Stomach	TGBC11TKB	10.8
Thyroid	8305C	10.6
Thyroid	8505C	10.5
Thyroid	BCPAP	10.7
Thyroid	BHT101	9.7
Thyroid	CAL62	11.4
Thyroid	CGTHW1	10.1
Thyroid	FTC133	10.3
Thyroid	FTC238	10.2
Thyroid	ML1	10.6
Thyroid	SW579	10.6
Thyroid	TT2609C02	10.3
Thyroid	TT	11.2
Upper aerodigestive tract	BHY	10.4
Upper aerodigestive tract	BICR16	9.8
Upper aerodigestive tract	BICR18	10.4
Upper aerodigestive tract	BICR22	10
Upper aerodigestive tract	BICR31	10.4
Upper aerodigestive tract	BICR56	10.5
Upper aerodigestive tract	BICR6	10.1
Upper aerodigestive tract	CAL27	10.3
Upper aerodigestive tract	CAL33	10.5
Upper aerodigestive tract	DETROIT562	10.4
Upper aerodigestive tract	FADU	10.4
Upper aerodigestive tract	HS840T	9.7
Upper aerodigestive tract	HSC2	10.3
Upper aerodigestive tract	HSC3	9.6
Upper aerodigestive tract	HSC4	11.4
Upper aerodigestive tract	PECAPJ15	10.7
Upper aerodigestive tract	PECAPJ34CLONEC12	10.2
Upper aerodigestive tract	PECAPJ41CLONED2	10
Upper aerodigestive tract	PECAPJ49	10.6
Upper aerodigestive tract	SCC15	10.2
Upper aerodigestive tract	SCC25	9.7
Upper aerodigestive tract	SCC4	10
Upper aerodigestive tract	SCC9	10.5
Upper aerodigestive tract	SNU1076	10.7
Upper aerodigestive tract	SNU1214	9.8
Upper aerodigestive tract	SNU46	10.6
Upper aerodigestive tract	SNU899	10.7
Upper aerodigestive tract	YD10B	10.4
Upper aerodigestive tract	YD38	10
Upper aerodigestive tract	YD8	11
Urinary tract	5637	10.4
Urinary tract	639V	11
Urinary tract	647V	10
Urinary tract	BC3C	10.2
Urinary tract	BFTC905	10.5
Urinary tract	CAL29	10.9
Urinary tract	HS172T	9.7
Urinary tract	HT1197	10.1
Urinary tract	HT1376	9.9
Urinary tract	J82	10.4
Urinary tract	JMSU1	10.8
Urinary tract	KMBC2	10.9
Urinary tract	KU1919	10.9
Urinary tract	RT11284	10.8
Urinary tract	RT112	10.7
Urinary tract	RT4	10.4
Urinary tract	SCABER	9.9
Urinary tract	SW1710	10.7
Urinary tract	SW780	10.7
Urinary tract	T24	10.5
Urinary tract	TCCSUP	10.4
Urinary tract	UMUC1	10.7
Urinary tract	UMUC3	10
Urinary tract	VMCUB1	10.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	24.7
Adrenal gland	25.1
Appendix	29.6
Bone marrow	16.8
Breast	36.9
Cerebral cortex	38.4
Cervix, uterine	39
Colon	22.9
Duodenum	21.1
Endometrium	53
Epididymis	39.6
Esophagus	28.2
Fallopian tube	48.9
Gallbladder	38.1
Heart muscle	13.4
Kidney	25.5
Liver	12
Lung	33.9
Lymph node	36.7
Ovary	50.8
Pancreas	4.4
Parathyroid gland	80.3
Placenta	38.2
Prostate	45
Rectum	27.4
Salivary gland	9.4
Seminal vesicle	38.1
Skeletal muscle	12.5
Skin	33.6
Small intestine	22.7
Smooth muscle	44.5
Spleen	34.6
Stomach	24.4
Testis	70.9
Thyroid gland	53.2
Tonsil	34.7
Urinary bladder	35.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27903678	Overexpression	Colon Carcinoma	ADNP was overexpressed in colon cancer cells with high WNT activity, where it acted as a WNT repressor.
22454142	Overexpression	Malignant Peripheral Nerve Sheath Tumor	Altogether, these finding provide evidence for the involvement of an endogenous PACAP-mediated ADNP signaling system that increases MPNST cell resistance to H(2)O(2)-induced death upon serum starvation.

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.363	4.89e-14	3.2	36.1	60.6	Gain
BRCA	Breast invasive carcinoma	1075	0.434	1.12e-50	3.7	47.5	48.7	Gain
CESC	Cervical and endocervical cancers	292	0.27	2.87e-06	4.8	54.5	40.8	Gain
COAD	Colon adenocarcinoma	449	0.669	1.75e-59	0	27.6	72.4	Gain
ESCA	Esophageal carcinoma	183	0.511	1.49e-13	3.3	30.6	66.1	Gain
GBM	Glioblastoma multiforme	147	0.428	6.4e-08	2	61.2	36.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.252	6.77e-09	6.4	55.6	37.9	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.144	0.000913	0	76.8	23.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.273	2.61e-06	0.3	64.6	35.1	Gain
LAML	Acute Myeloid Leukemia	166	0.161	0.0378	1.8	98.2	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.17	0.000112	1.2	90.1	8.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.203	9.36e-05	3.3	63.7	33	Neutral
LUAD	Lung adenocarcinoma	512	0.545	6.71e-41	13.1	44.3	42.6	Gain
LUSC	Lung squamous cell carcinoma	498	0.553	3.18e-41	9.4	38	52.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.55	3.96e-25	3.3	26.3	70.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.43	2.36e-09	2.8	72.3	24.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.353	4.04e-06	1.9	91.4	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.172	0.00013	0.8	91	8.1	Neutral
READ	Rectum adenocarcinoma	164	0.482	6.53e-11	0	12.2	87.8	Gain
SARC	Sarcoma	255	0.197	0.0016	5.5	54.9	39.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.469	1.78e-21	1.1	47.7	51.2	Gain
STAD	Stomach adenocarcinoma	413	0.563	7.59e-36	0.7	32.9	66.3	Gain
TGCT	Testicular Germ Cell Tumors	150	0.182	0.0262	7.3	63.3	29.3	Neutral
THCA	Thyroid carcinoma	497	0.019	0.677	0	97.6	2.4	Neutral
THYM	Thymoma	119	-0.01	0.914	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.305	5.39e-13	2	71.3	26.6	Neutral

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.348	2.11e-13	17	408	-0.232	1.3e-09	Decreased
BRCA	Breast invasive carcinoma	-0.366	0	83	785	0	0.0248	NS/NA
CESC	Cervical and endocervical cancers	-0.241	1.94e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.347	3.11e-10	19	297	-0.001	0.849	NS/NA
ESCA	Esophageal carcinoma	-0.34	1.4e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.29	0.0193	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.256	1.57e-09	20	522	0.001	0.0453	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.164	0.00231	24	319	0.002	1.79e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.261	5.57e-06	23	275	0.005	0.0159	NS/NA
LAML	Acute Myeloid Leukemia	-0.137	0.0757	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.136	0.00176	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.169	0.000575	41	373	0.001	0.00191	NS/NA
LUAD	Lung adenocarcinoma	-0.156	0.000653	21	456	-0.002	0.865	NS/NA
LUSC	Lung squamous cell carcinoma	-0.195	0.000141	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.867	0.00451	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.213	0.00378	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.21	0.0039	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.204	2.06e-06	35	498	-0.007	0.0294	NS/NA
READ	Rectum adenocarcinoma	-0.262	0.00837	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.27	9.58e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.361	5.55e-16	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.366	4.06e-13	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.455	3.49e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.119	0.0049	50	509	-0.042	0.795	NS/NA
THYM	Thymoma	-0.317	0.000394	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.179	0.000106	34	431	-0.002	0.0291	NS/NA

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	3	High
Kidney	2	Medium
Liver	0	Not detected
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.462	NS	24476821
BRCA	Breast invasive carcinoma	521	4.53e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	7.27e-13	Significant	22810696
GBM	Glioblastoma multiforme	157	9.01e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.51e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0482	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.0691	NS	26824661
LUAD	Lung adenocarcinoma	230	0.0053	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00255	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.14e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000113	Significant	26544944
READ	Rectum adenocarcinoma	67	0.000293	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.026	Significant	26091043
STAD	Stomach adenocarcinoma	277	2.65e-10	Significant	25079317
THCA	Thyroid carcinoma	391	6.03e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000213	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.976	0.912	NS
BRCA	Breast invasive carcinoma	1079	1.322	0.227	NS
CESC	Cervical and endocervical cancers	291	1.443	0.324	NS
COAD	Colon adenocarcinoma	439	0.867	0.607	NS
ESCA	Esophageal carcinoma	184	0.968	0.921	NS
GBM	Glioblastoma multiforme	158	0.74	0.23	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.7	0.07	NS
KIRC	Kidney renal clear cell carcinoma	531	0.602	0.0148	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.29	0.549	NS
LAML	Acute Myeloid Leukemia	149	0.566	0.044	Longer
LGG	Brain Lower Grade Glioma	511	1.027	0.917	NS
LIHC	Liver hepatocellular carcinoma	365	1.387	0.17	NS
LUAD	Lung adenocarcinoma	502	1.156	0.494	NS
LUSC	Lung squamous cell carcinoma	494	0.916	0.656	NS
OV	Ovarian serous cystadenocarcinoma	303	1.408	0.0925	NS
PAAD	Pancreatic adenocarcinoma	177	1.075	0.799	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1727737621.699	0.0739	NS
PRAD	Prostate adenocarcinoma	497	5.926	0.0752	NS
READ	Rectum adenocarcinoma	159	0.982	0.975	NS
SARC	Sarcoma	259	1.752	0.0554	NS
SKCM	Skin Cutaneous Melanoma	459	0.96	0.838	NS
STAD	Stomach adenocarcinoma	388	0.88	0.57	NS
TGCT	Testicular Germ Cell Tumors	134	1.02	0.989	NS
THCA	Thyroid carcinoma	500	2.231	0.325	NS
THYM	Thymoma	119	1.137	0.89	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.647	0.0919	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.051	0.302	NS
BRCA	Breast invasive carcinoma	1071	0.013	0.682	NS
CESC	Cervical and endocervical cancers	167	-0.026	0.735	NS
COAD	Colon adenocarcinoma	445	0.051	0.288	NS
ESCA	Esophageal carcinoma	162	-0.047	0.553	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.046	0.334	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.111	0.0105	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.098	0.113	NS
LIHC	Liver hepatocellular carcinoma	347	0.105	0.0517	NS
LUAD	Lung adenocarcinoma	507	0.024	0.584	NS
LUSC	Lung squamous cell carcinoma	497	-0.03	0.51	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.072	0.215	NS
PAAD	Pancreatic adenocarcinoma	176	-0.039	0.608	NS
READ	Rectum adenocarcinoma	156	0.067	0.403	NS
SKCM	Skin Cutaneous Melanoma	410	-0.096	0.051	NS
STAD	Stomach adenocarcinoma	392	0.02	0.691	NS
TGCT	Testicular Germ Cell Tumors	81	-0.153	0.174	NS
THCA	Thyroid carcinoma	499	-0.01	0.831	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.102	0.0227	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.047	0.444	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.151	0.000711	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.12	0.00589	Lower
LGG	Brain Lower Grade Glioma	514	0.081	0.0654	NS
LIHC	Liver hepatocellular carcinoma	366	0.099	0.0575	NS
OV	Ovarian serous cystadenocarcinoma	296	0.055	0.342	NS
PAAD	Pancreatic adenocarcinoma	176	0.072	0.345	NS
STAD	Stomach adenocarcinoma	406	-0.211	1.78e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.244	1.14e-08	Higher

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ADNP.

Summary
Symbol	ADNP
Name	activity dependent neuroprotector homeobox
Aliases	KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ......
Location	20q13.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27903678	Colon Carcinoma	downstream	WNT	Negative regulation	ADNP was overexpressed in colon cancer cells with high WNT activity, where it acted as a WNT repressor.
22454142	Malignant Peripheral Nerve Sheath Tumor	upstream	PACAP	positive regulation	Treatment with PACAP38 (10(-9) to 10(-5) M) dose-dependently increased ADNP levels in NS but not in SS cells. PAC(1)/VPAC receptor antagonists completely suppressed PACAP-stimulated ADNP increase and partially reduced ADNP expression in SS cells.