CR2Cancer

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF17035 Bromodomain extra-terminal - transcription regulation
PF17105 C-terminal domain of bromodomain protein 4
PF00439 Bromodomain

Function

Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters. ; FUNCTION: Isoform B: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AFX/H2A.x phosphorylation.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9, H3K14, H4K5, H4K12	#	12840145

> Gene Ontology [ TOP ]
Biological Process	GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007346 regulation of mitotic cell cycle GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0032784 regulation of DNA-templated transcription, elongation GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0034243 regulation of transcription elongation from RNA polymerase II promoter GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0044843 cell cycle G1/S phase transition GO:0045787 positive regulation of cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0050727 regulation of inflammatory response GO:0070816 phosphorylation of RNA polymerase II C-terminal domain GO:0090068 positive regulation of cell cycle process GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902749 regulation of cell cycle G2/M phase transition GO:1902751 positive regulation of cell cycle G2/M phase transition
Molecular Function	GO:0000993 RNA polymerase II core binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0002039 p53 binding GO:0003682 chromatin binding GO:0042393 histone binding GO:0043175 RNA polymerase core enzyme binding GO:0070063 RNA polymerase binding GO:0070577 lysine-acetylated histone binding
Cellular Component	GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3283283	c.1446G>A	p.P482P	Substitution - coding silent	Stomach
COSM5019999	c.360G>T	p.W120C	Substitution - Missense	Soft_tissue
COSM460042	c.387C>A	p.F129L	Substitution - Missense	Cervix
COSM4131320	c.1950C>T	p.D650D	Substitution - coding silent	Thyroid
COSM5760346	c.1779C>G	p.S593R	Substitution - Missense	Bone
COSM3529610	c.677C>T	p.P226L	Substitution - Missense	Skin
COSM3529613	c.675C>T	p.F225F	Substitution - coding silent	Skin
COSM4074983	c.618G>T	p.P206P	Substitution - coding silent	Stomach
COSM992130	c.2071G>A	p.G691S	Substitution - Missense	Endometrium
COSM249234	c.2080A>T	p.K694*	Substitution - Nonsense	Kidney
COSM474274	c.497C>A	p.T166K	Substitution - Missense	Kidney
COSM992157	c.286G>A	p.D96N	Substitution - Missense	Endometrium
COSM4750299	c.542G>C	p.R181P	Substitution - Missense	Stomach
COSM1165545	c.584C>T	p.T195M	Substitution - Missense	Large_intestine
COSM5343232	c.1293G>A	p.K431K	Substitution - coding silent	Large_intestine
COSM5388876	c.68C>T	p.T23I	Substitution - Missense	Skin
COSM1184896	c.2005C>T	p.R669C	Substitution - Missense	Large_intestine
COSM390796	c.709C>T	p.P237S	Substitution - Missense	Lung
COSM3529595	c.1409C>T	p.S470F	Substitution - Missense	Skin
COSM5916685	c.1752-5C>T	p.?	Unknown	Skin
COSM4623848	c.1294T>C	p.Y432H	Substitution - Missense	Large_intestine
COSM4131323	c.966G>A	p.R322R	Substitution - coding silent	Thyroid
COSM1391088	c.1261G>C	p.D421H	Substitution - Missense	Large_intestine
COSM4074993	c.190C>T	p.Q64*	Substitution - Nonsense	Stomach
COSM1680759	c.1352A>G	p.E451G	Substitution - Missense	Large_intestine
COSM6004136	c.1345G>A	p.V449M	Substitution - Missense	Prostate
COSM3712821	c.1400C>A	p.A467D	Substitution - Missense	Upper_aerodigestive_tract
COSM5419116	c.2141G>A	p.S714N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4074996	c.138G>A	p.P46P	Substitution - coding silent	Stomach
COSM1580616	c.682G>A	p.V228I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3529589	c.1705C>T	p.P569S	Substitution - Missense	Skin
COSM4604622	c.1948G>A	p.D650N	Substitution - Missense	Upper_aerodigestive_tract
COSM417732	c.1510G>A	p.E504K	Substitution - Missense	Urinary_tract
COSM5365245	c.9G>A	p.A3A	Substitution - coding silent	Large_intestine
COSM992136	c.1918C>T	p.R640W	Substitution - Missense	Endometrium
COSM4915559	c.602A>C	p.Q201P	Substitution - Missense	Liver
COSM4666104	c.1896C>T	p.R632R	Substitution - coding silent	Large_intestine
COSM1184894	c.167C>A	p.P56H	Substitution - Missense	Large_intestine
COSM3529616	c.136C>T	p.P46S	Substitution - Missense	Skin
COSM4978303	c.1396G>T	p.V466L	Substitution - Missense	Oesophagus
COSM4666110	c.589C>T	p.P197S	Substitution - Missense	Large_intestine
COSM1391080	c.1729A>G	p.N577D	Substitution - Missense	Large_intestine
COSM3742791	c.1545G>A	p.Q515Q	Substitution - coding silent	Liver
COSM384349	c.655C>G	p.Q219E	Substitution - Missense	Lung
COSM992133	c.1962C>T	p.I654I	Substitution - coding silent	Endometrium
COSM1611719	c.899T>C	p.I300T	Substitution - Missense	Liver
COSM4666116	c.468C>A	p.L156L	Substitution - coding silent	Large_intestine
COSM1391078	c.1894C>T	p.R632C	Substitution - Missense	Large_intestine
COSM270689	c.625C>G	p.Q209E	Substitution - Missense	Large_intestine
COSM992151	c.1097C>T	p.A366V	Substitution - Missense	Endometrium
COSM1641075	c.618G>A	p.P206P	Substitution - coding silent	Stomach
COSM4895316	c.2117C>T	p.S706F	Substitution - Missense	Skin
COSM5618553	c.449C>T	p.A150V	Substitution - Missense	Breast
COSM5388870	c.1932G>A	p.L644L	Substitution - coding silent	Skin
COSM992148	c.1357C>T	p.R453C	Substitution - Missense	Endometrium
COSM3362725	c.698T>A	p.I233N	Substitution - Missense	Kidney
COSM1391090	c.815C>T	p.P272L	Substitution - Missense	Large_intestine
COSM1480707	c.1638G>C	p.K546N	Substitution - Missense	Breast
COSM4879008	c.1719G>A	p.T573T	Substitution - coding silent	Prostate
COSM5967912	c.495C>A	p.P165P	Substitution - coding silent	Genital_tract
COSM5741478	c.1279T>C	p.S427P	Substitution - Missense	Small_intestine
COSM3283285	c.1379A>G	p.E460G	Substitution - Missense	Large_intestine
COSM3283243	c.2108C>T	p.S703L	Substitution - Missense	Large_intestine
COSM5641321	c.1994G>A	p.R665H	Substitution - Missense	Oesophagus
COSM3891706	c.581C>T	p.S194F	Substitution - Missense	Skin
COSM318941	c.1259C>A	p.A420D	Substitution - Missense	Lung
COSM5718015	c.613C>T	p.P205S	Substitution - Missense	Skin
COSM3529586	c.1814A>T	p.D605V	Substitution - Missense	Skin
COSM1711945	c.1081C>T	p.L361F	Substitution - Missense	Skin
COSM4394171	c.444A>G	p.L148L	Substitution - coding silent	Skin
COSM4951689	c.1708C>A	p.P570T	Substitution - Missense	Liver
COSM4916160	c.1369A>T	p.M457L	Substitution - Missense	Liver
COSM3529604	c.920C>T	p.P307L	Substitution - Missense	Skin
COSM4074990	c.330A>T	p.I110I	Substitution - coding silent	Stomach
COSM709705	c.2094C>G	p.F698L	Substitution - Missense	Lung
COSM3283339	c.118G>A	p.A40T	Substitution - Missense	Oesophagus
COSM3742794	c.1351G>A	p.E451K	Substitution - Missense	Large_intestine
COSM3362722	c.1596G>A	p.Q532Q	Substitution - coding silent	Kidney
COSM4074979	c.1597C>A	p.Q533K	Substitution - Missense	Stomach
COSM1391082	c.1584C>A	p.L528L	Substitution - coding silent	Large_intestine
COSM4995847	c.1677G>C	p.E559D	Substitution - Missense	Upper_aerodigestive_tract
COSM5365245	c.9G>A	p.A3A	Substitution - coding silent	Large_intestine
COSM3529607	c.699C>T	p.I233I	Substitution - coding silent	Skin
COSM1391078	c.1894C>T	p.R632C	Substitution - Missense	Large_intestine
COSM3362719	c.1835A>G	p.Y612C	Substitution - Missense	Kidney
COSM4074976	c.1985C>T	p.S662F	Substitution - Missense	Stomach
COSM1480707	c.1638G>C	p.K546N	Substitution - Missense	Cervix
COSM3283309	c.576C>T	p.G192G	Substitution - coding silent	Large_intestine
COSM3283245	c.2097G>A	p.S699S	Substitution - coding silent	Stomach
COSM992154	c.576C>A	p.G192G	Substitution - coding silent	Endometrium
COSM3403856	c.1278C>A	p.F426L	Substitution - Missense	Central_nervous_system
COSM3529592	c.1410C>T	p.S470S	Substitution - coding silent	Skin
COSM1680759	c.1352A>G	p.E451G	Substitution - Missense	Large_intestine
COSM1325443	c.2031G>A	p.K677K	Substitution - coding silent	Ovary
COSM5351783	c.1108G>A	p.A370T	Substitution - Missense	Kidney
COSM4405787	c.1785C>T	p.P595P	Substitution - coding silent	Skin
COSM3529601	c.976C>T	p.R326W	Substitution - Missense	Skin
COSM5718015	c.613C>T	p.P205S	Substitution - Missense	Skin
COSM1246218	c.747G>C	p.T249T	Substitution - coding silent	Stomach
COSM5418005	c.560-10T>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1391086	c.1267C>T	p.R423*	Substitution - Nonsense	Large_intestine
COSM3283307	c.605C>G	p.A202G	Substitution - Missense	Lung
COSM3422497	c.15C>T	p.S5S	Substitution - coding silent	Stomach
COSM1711947	c.991_992CC>TT	p.P331L	Substitution - Missense	Skin
COSM73859	c.374G>A	p.C125Y	Substitution - Missense	Ovary
COSM1680759	c.1352A>G	p.E451G	Substitution - Missense	Large_intestine
COSM5770830	c.1110C>T	p.A370A	Substitution - coding silent	Breast
COSM4397069	c.1912C>T	p.Q638*	Substitution - Nonsense	Skin
COSM3529598	c.1124C>T	p.P375L	Substitution - Missense	Skin
COSM5755282	c.182A>C	p.N61T	Substitution - Missense	Large_intestine
COSM992139	c.1878C>T	p.P626P	Substitution - coding silent	Endometrium
COSM5056312	c.530A>C	p.K177T	Substitution - Missense	Stomach
COSM1290883	c.1445C>A	p.P482Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5580360	c.300C>T	p.I100I	Substitution - coding silent	Skin
COSM3712821	c.1400C>A	p.A467D	Substitution - Missense	Upper_aerodigestive_tract
COSM4185921	c.360G>C	p.W120C	Substitution - Missense	Kidney
COSM992145	c.1471G>A	p.D491N	Substitution - Missense	Endometrium
COSM4140337	c.1240G>C	p.D414H	Substitution - Missense	Ovary
COSM1680763	c.218C>T	p.T73I	Substitution - Missense	Skin
COSM309518	c.1002C>T	p.D334D	Substitution - coding silent	Lung
COSM3362716	c.2149T>C	p.S717P	Substitution - Missense	Kidney
COSM6003824	c.2159-8C>G	p.?	Unknown	Prostate
COSM992142	c.1707T>A	p.P569P	Substitution - coding silent	Endometrium
COSM4878668	c.1696A>G	p.K566E	Substitution - Missense	Prostate
COSM1580618	c.652G>C	p.V218L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4188054	c.212T>C	p.L71P	Substitution - Missense	Kidney
COSM1184899	c.1680T>A	p.N560K	Substitution - Missense	Large_intestine
COSM1391100	c.266C>T	p.A89V	Substitution - Missense	Large_intestine
COSM3891709	c.283C>T	p.P95S	Substitution - Missense	Skin
COSM3422494	c.1919G>A	p.R640Q	Substitution - Missense	Large_intestine
COSM3283289	c.1330C>T	p.R444C	Substitution - Missense	Large_intestine
COSM212103	c.999G>C	p.K333N	Substitution - Missense	Breast
COSM1391086	c.1267C>T	p.R423*	Substitution - Nonsense	Large_intestine
COSM4982236	c.2046A>T	p.Q682H	Substitution - Missense	Oesophagus
COSM4666107	c.1895G>A	p.R632H	Substitution - Missense	Large_intestine
COSM5224678	c.1715delA	p.K572fs*12	Deletion - Frameshift	Breast
COSM3422494	c.1919G>A	p.R640Q	Substitution - Missense	Large_intestine
COSM3672753	c.912C>A	p.H304Q	Substitution - Missense	Prostate
COSM5441067	c.431A>G	p.D144G	Substitution - Missense	Oesophagus
COSM4666119	c.350A>G	p.N117S	Substitution - Missense	Large_intestine
COSM397002	c.984G>A	p.V328V	Substitution - coding silent	Lung
COSM4074986	c.587T>C	p.V196A	Substitution - Missense	Stomach
COSM3422497	c.15C>T	p.S5S	Substitution - coding silent	Large_intestine
COSM1184899	c.1680T>A	p.N560K	Substitution - Missense	Oesophagus
COSM3742794	c.1351G>A	p.E451K	Substitution - Missense	Liver
COSM220389	c.2008T>C	p.Y670H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1680761	c.359G>A	p.W120*	Substitution - Nonsense	Large_intestine
COSM3891703	c.906C>T	p.P302P	Substitution - coding silent	Skin
COSM1391092	c.756_759delAGTG	p.V253fs*29	Deletion - Frameshift	Large_intestine
COSM992160	c.87A>G	p.T29T	Substitution - coding silent	Endometrium
COSM4648213	c.883A>C	p.T295P	Substitution - Missense	Large_intestine
COSM5718015	c.613C>T	p.P205S	Substitution - Missense	Skin
COSM249234	c.2080A>T	p.K694*	Substitution - Nonsense	Kidney
COSM4666113	c.541C>T	p.R181C	Substitution - Missense	Large_intestine
COSM3932913	c.668A>C	p.H223P	Substitution - Missense	Urinary_tract
COSM1391076	c.1957G>T	p.E653*	Substitution - Nonsense	Large_intestine
COSM5022011	c.138G>C	p.P46P	Substitution - coding silent	Bone
COSM4402526	c.2022T>G	p.C674W	Substitution - Missense	Skin
COSM1680761	c.359G>A	p.W120*	Substitution - Nonsense	Large_intestine
COSM5015587	c.512T>C	p.I171T	Substitution - Missense	Kidney
COSM1659209	c.1682A>G	p.K561R	Substitution - Missense	Kidney
COSM5388873	c.928C>T	p.P310S	Substitution - Missense	Skin
COSM3283309	c.576C>T	p.G192G	Substitution - coding silent	Stomach
COSM4185623	c.1246C>T	p.Q416*	Substitution - Nonsense	Kidney
COSM1611719	c.899T>C	p.I300T	Substitution - Missense	Liver
COSM3529619	c.33G>T	p.L11F	Substitution - Missense	Skin
COSM80920	c.585G>C	p.T195T	Substitution - coding silent	Ovary
COSM4951689	c.1708C>A	p.P570T	Substitution - Missense	Liver
COSM5445537	c.840G>A	p.Q280Q	Substitution - coding silent	Oesophagus

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
24655834	Mutation	NUT Midline Carcinoma	Cytogenetic and fluorescence in situ hybridization analyses revealed a t(15;19) and BRD4-NUT gene rearrangement.
20871596	Mutation	Human Squamous Carcinoma	Recurrent translocation of BRD4 is observed in a genetically-defined, incurable subtype of human squamous carcinoma.

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O60885	484	S	Phosphoserine	CK2	No	None detected
O60885	488	S	Phosphoserine	CK2	No	None detected
O60885	492	S	Phosphoserine	CK2	No	None detected
O60885	494	S	Phosphoserine	CK2	No	None detected
O60885	498	S	Phosphoserine	CK2	No	None detected
O60885	499	S	Phosphoserine	CK2	No	None detected
O60885	503	S	Phosphoserine	CK2	No	None detected
O60885	601	S	Phosphoserine	-	No	None detected
O60885	1111	K	N6-acetyllysine	-	No	None detected
O60885	1117	S	Phosphoserine	-	No	None detected
O60885	1126	S	Phosphoserine	-	No	None detected
O60885	1201	S	Phosphoserine	-	No	None detected
O60885	1204	S	Phosphoserine	-	No	None detected

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.373	6.502	0.136	0.321	NS
BRCA	Breast invasive carcinoma	112	1100	6.167	6.478	0.298	5.11e-10	NS
CESC	Cervical and endocervical cancers	3	306	6.228	6.53	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.435	6.53	0.212	0.0066	NS
ESCA	Esophageal carcinoma	11	185	7.255	7.523	0.238	0.212	NS
GBM	Glioblastoma multiforme	5	166	6.757	6.441	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.506	6.687	0.189	0.0485	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.243	6.211	-0.004	0.941	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.477	6.164	-0.325	0.000288	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.673	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.405	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.898	5.713	-0.161	0.0852	NS
LUAD	Lung adenocarcinoma	59	517	6.4	6.34	-0.064	0.407	NS
LUSC	Lung squamous cell carcinoma	51	501	6.428	6.912	0.477	4.62e-07	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.582	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.429	6.292	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.511	6.017	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.329	6.32	0.024	0.743	NS
READ	Rectum adenocarcinoma	10	167	6.186	6.571	0.589	0.00069	Over
SARC	Sarcoma	2	263	5.59	6.694	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.396	6.847	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.892	7.154	0.347	4.71e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.017	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.198	6.044	-0.164	0.00225	NS
THYM	Thymoma	2	120	7.017	6.582	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.373	6.859	0.372	0.00241	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.2
Autonomic ganglia	CHP212	7.9
Autonomic ganglia	IMR32	8.6
Autonomic ganglia	KELLY	7.8
Autonomic ganglia	KPNRTBM1	8.3
Autonomic ganglia	KPNSI9S	7.5
Autonomic ganglia	KPNYN	8.4
Autonomic ganglia	MHHNB11	8.9
Autonomic ganglia	NB1	8.2
Autonomic ganglia	NH6	8
Autonomic ganglia	SHSY5Y	8.1
Autonomic ganglia	SIMA	8.2
Autonomic ganglia	SKNAS	8.2
Autonomic ganglia	SKNBE2	8.1
Autonomic ganglia	SKNDZ	7.9
Autonomic ganglia	SKNFI	7.9
Autonomic ganglia	SKNSH	7.5
Biliary tract	HUCCT1	7.7
Biliary tract	HUH28	8.1
Biliary tract	SNU1079	8.3
Biliary tract	SNU1196	8.3
Biliary tract	SNU245	7.7
Biliary tract	SNU308	8.9
Biliary tract	SNU478	8.8
Bone	143B	8.6
Bone	A673	8.1
Bone	CADOES1	8.2
Bone	CAL78	8.3
Bone	G292CLONEA141B1	8.7
Bone	HOS	8
Bone	HS706T	8
Bone	HS737T	8.2
Bone	HS819T	7.9
Bone	HS821T	8.2
Bone	HS822T	7.8
Bone	HS863T	7.9
Bone	HS870T	7.6
Bone	HS888T	8
Bone	MG63	9.3
Bone	MHHES1	8.7
Bone	OUMS27	8.3
Bone	RDES	8
Bone	SJSA1	8.4
Bone	SKES1	8.3
Bone	SKNMC	8.8
Bone	SW1353	8.4
Bone	T173	8
Bone	TC71	8
Bone	U2OS	7.8
Breast	AU565	7.7
Breast	BT20	8.2
Breast	BT474	8.7
Breast	BT483	7.4
Breast	BT549	8.5
Breast	CAL120	8.1
Breast	CAL148	8.7
Breast	CAL51	8.3
Breast	CAL851	7.5
Breast	CAMA1	8
Breast	DU4475	9
Breast	EFM192A	7.6
Breast	EFM19	8.3
Breast	EVSAT	7.9
Breast	HCC1143	10.6
Breast	HCC1187	8.4
Breast	HCC1395	8.9
Breast	HCC1419	8.1
Breast	HCC1428	7.5
Breast	HCC1500	7.5
Breast	HCC1569	8.1
Breast	HCC1599	8
Breast	HCC1806	8.4
Breast	HCC1937	8.9
Breast	HCC1954	7.5
Breast	HCC202	7.8
Breast	HCC2157	8.2
Breast	HCC2218	7.4
Breast	HCC38	8.4
Breast	HCC70	8.7
Breast	HDQP1	8.6
Breast	HMC18	8.1
Breast	HS274T	8.2
Breast	HS281T	7.9
Breast	HS343T	8
Breast	HS578T	8.3
Breast	HS606T	7.6
Breast	HS739T	7.8
Breast	HS742T	7.7
Breast	JIMT1	7.9
Breast	KPL1	8
Breast	MCF7	8.1
Breast	MDAMB134VI	7.4
Breast	MDAMB157	8
Breast	MDAMB175VII	7.9
Breast	MDAMB231	8.4
Breast	MDAMB361	8.1
Breast	MDAMB415	7.5
Breast	MDAMB436	8.6
Breast	MDAMB453	8.1
Breast	MDAMB468	8.4
Breast	SKBR3	7.9
Breast	T47D	7.5
Breast	UACC812	8.1
Breast	UACC893	7.9
Breast	YMB1	7.9
Breast	ZR751	7.1
Breast	ZR7530	7.8
Central nervous system	1321N1	8.9
Central nervous system	42MGBA	8
Central nervous system	8MGBA	7.6
Central nervous system	A172	7.3
Central nervous system	AM38	8
Central nervous system	BECKER	8.3
Central nervous system	CAS1	7.8
Central nervous system	CCFSTTG1	8.1
Central nervous system	D283MED	8.2
Central nervous system	D341MED	8.2
Central nervous system	DAOY	8.1
Central nervous system	DBTRG05MG	7.5
Central nervous system	DKMG	8.1
Central nervous system	GAMG	7.6
Central nervous system	GB1	8.8
Central nervous system	GI1	8.3
Central nervous system	GMS10	8.1
Central nervous system	GOS3	8.3
Central nervous system	H4	8.3
Central nervous system	HS683	8.1
Central nervous system	KALS1	7.7
Central nervous system	KG1C	7.2
Central nervous system	KNS42	8
Central nervous system	KNS60	7.6
Central nervous system	KNS81	7.3
Central nervous system	KS1	8
Central nervous system	LN18	8.2
Central nervous system	LN229	7.9
Central nervous system	M059K	8.4
Central nervous system	MOGGCCM	8
Central nervous system	MOGGUVW	7.9
Central nervous system	NMCG1	7.2
Central nervous system	ONS76	8.5
Central nervous system	SF126	8.1
Central nervous system	SF295	8.4
Central nervous system	SNB19	8
Central nervous system	SNU1105	8.4
Central nervous system	SNU201	8.2
Central nervous system	SNU466	8.5
Central nervous system	SNU489	8.8
Central nervous system	SNU626	7.9
Central nervous system	SNU738	8.2
Central nervous system	SW1088	8
Central nervous system	SW1783	7.5
Central nervous system	T98G	8.1
Central nervous system	TM31	8
Central nervous system	U118MG	9.1
Central nervous system	U138MG	8.6
Central nervous system	U251MG	7.8
Central nervous system	U87MG	8.4
Central nervous system	YH13	8.1
Central nervous system	YKG1	7.6
Endometrium	AN3CA	8.2
Endometrium	COLO684	8.8
Endometrium	EFE184	8.6
Endometrium	EN	8.5
Endometrium	ESS1	8.1
Endometrium	HEC108	7.4
Endometrium	HEC151	7.9
Endometrium	HEC1A	7.4
Endometrium	HEC1B	7.6
Endometrium	HEC251	7.2
Endometrium	HEC265	7.9
Endometrium	HEC50B	7.8
Endometrium	HEC59	8.4
Endometrium	HEC6	7.8
Endometrium	ISHIKAWAHERAKLIO02ER	7.3
Endometrium	JHUEM1	8.2
Endometrium	JHUEM2	8
Endometrium	JHUEM3	8.1
Endometrium	KLE	7.6
Endometrium	MFE280	8.7
Endometrium	MFE296	8.3
Endometrium	MFE319	8.6
Endometrium	RL952	8.7
Endometrium	SNGM	8.4
Endometrium	SNU1077	7.6
Endometrium	SNU685	8.2
Endometrium	TEN	7.9
Haematopoietic and lymphoid	697	8.5
Haematopoietic and lymphoid	A3KAW	7.6
Haematopoietic and lymphoid	A4FUK	7.9
Haematopoietic and lymphoid	ALLSIL	8.5
Haematopoietic and lymphoid	AML193	8.5
Haematopoietic and lymphoid	AMO1	8.4
Haematopoietic and lymphoid	BCP1	8.2
Haematopoietic and lymphoid	BDCM	7.8
Haematopoietic and lymphoid	BL41	8.5
Haematopoietic and lymphoid	BL70	8.7
Haematopoietic and lymphoid	BV173	9
Haematopoietic and lymphoid	CA46	9
Haematopoietic and lymphoid	CI1	8.7
Haematopoietic and lymphoid	CMK115	8.1
Haematopoietic and lymphoid	CMK86	8.8
Haematopoietic and lymphoid	CMK	8.5
Haematopoietic and lymphoid	CMLT1	8.6
Haematopoietic and lymphoid	COLO775	8.7
Haematopoietic and lymphoid	DAUDI	8.3
Haematopoietic and lymphoid	DB	8.4
Haematopoietic and lymphoid	DEL	8.6
Haematopoietic and lymphoid	DND41	8.7
Haematopoietic and lymphoid	DOHH2	8.4
Haematopoietic and lymphoid	EB1	8.8
Haematopoietic and lymphoid	EB2	9
Haematopoietic and lymphoid	EHEB	8.2
Haematopoietic and lymphoid	EJM	8.5
Haematopoietic and lymphoid	EM2	8.9
Haematopoietic and lymphoid	EOL1	8.6
Haematopoietic and lymphoid	F36P	8.1
Haematopoietic and lymphoid	GA10	8.5
Haematopoietic and lymphoid	GDM1	7.9
Haematopoietic and lymphoid	GRANTA519	8.4
Haematopoietic and lymphoid	HDLM2	7.8
Haematopoietic and lymphoid	HDMYZ	8
Haematopoietic and lymphoid	HEL9217	8
Haematopoietic and lymphoid	HEL	8.3
Haematopoietic and lymphoid	HH	8.3
Haematopoietic and lymphoid	HL60	9.4
Haematopoietic and lymphoid	HPBALL	8.8
Haematopoietic and lymphoid	HS604T	8.3
Haematopoietic and lymphoid	HS611T	8.1
Haematopoietic and lymphoid	HS616T	8.1
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	8.1
Haematopoietic and lymphoid	HTK	8.8
Haematopoietic and lymphoid	HUNS1	8.3
Haematopoietic and lymphoid	HUT102	8.2
Haematopoietic and lymphoid	HUT78	7.5
Haematopoietic and lymphoid	JEKO1	8.2
Haematopoietic and lymphoid	JK1	8.5
Haematopoietic and lymphoid	JM1	8
Haematopoietic and lymphoid	JURKAT	8.8
Haematopoietic and lymphoid	JURLMK1	8.5
Haematopoietic and lymphoid	JVM2	8.2
Haematopoietic and lymphoid	JVM3	8.8
Haematopoietic and lymphoid	K562	9.1
Haematopoietic and lymphoid	KARPAS299	8.7
Haematopoietic and lymphoid	KARPAS422	8.1
Haematopoietic and lymphoid	KARPAS620	8.4
Haematopoietic and lymphoid	KASUMI1	8.3
Haematopoietic and lymphoid	KASUMI2	8.3
Haematopoietic and lymphoid	KASUMI6	8.1
Haematopoietic and lymphoid	KCL22	8
Haematopoietic and lymphoid	KE37	8.4
Haematopoietic and lymphoid	KE97	7.5
Haematopoietic and lymphoid	KG1	8.6
Haematopoietic and lymphoid	KHM1B	7.9
Haematopoietic and lymphoid	KIJK	8.2
Haematopoietic and lymphoid	KMH2	8.5
Haematopoietic and lymphoid	KMM1	8.2
Haematopoietic and lymphoid	KMS11	8.1
Haematopoietic and lymphoid	KMS12BM	8.5
Haematopoietic and lymphoid	KMS18	8
Haematopoietic and lymphoid	KMS20	8.5
Haematopoietic and lymphoid	KMS21BM	7.6
Haematopoietic and lymphoid	KMS26	7.9
Haematopoietic and lymphoid	KMS27	8
Haematopoietic and lymphoid	KMS28BM	7.7
Haematopoietic and lymphoid	KMS34	7.9
Haematopoietic and lymphoid	KO52	8.1
Haematopoietic and lymphoid	KOPN8	9
Haematopoietic and lymphoid	KU812	9.3
Haematopoietic and lymphoid	KYO1	8.2
Haematopoietic and lymphoid	L1236	8.3
Haematopoietic and lymphoid	L363	9.1
Haematopoietic and lymphoid	L428	8.1
Haematopoietic and lymphoid	L540	8.4
Haematopoietic and lymphoid	LAMA84	8.4
Haematopoietic and lymphoid	LOUCY	8.2
Haematopoietic and lymphoid	LP1	7.9
Haematopoietic and lymphoid	M07E	8.7
Haematopoietic and lymphoid	MC116	8.3
Haematopoietic and lymphoid	ME1	8.3
Haematopoietic and lymphoid	MEC1	8.3
Haematopoietic and lymphoid	MEC2	8.8
Haematopoietic and lymphoid	MEG01	9.2
Haematopoietic and lymphoid	MHHCALL2	8.1
Haematopoietic and lymphoid	MHHCALL3	8.4
Haematopoietic and lymphoid	MHHCALL4	8.5
Haematopoietic and lymphoid	MINO	8.5
Haematopoietic and lymphoid	MJ	8.2
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	9
Haematopoietic and lymphoid	MOLM16	8.9
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	8.5
Haematopoietic and lymphoid	MOLP8	7.8
Haematopoietic and lymphoid	MOLT13	8.4
Haematopoietic and lymphoid	MOLT16	8.8
Haematopoietic and lymphoid	MOLT4	7.9
Haematopoietic and lymphoid	MONOMAC1	8.2
Haematopoietic and lymphoid	MONOMAC6	8.6
Haematopoietic and lymphoid	MOTN1	9.1
Haematopoietic and lymphoid	MUTZ5	8.2
Haematopoietic and lymphoid	MV411	9.5
Haematopoietic and lymphoid	NALM19	8.3
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	8.2
Haematopoietic and lymphoid	NAMALWA	9.2
Haematopoietic and lymphoid	NB4	8.4
Haematopoietic and lymphoid	NCIH929	7.4
Haematopoietic and lymphoid	NCO2	8.3
Haematopoietic and lymphoid	NOMO1	8.3
Haematopoietic and lymphoid	NUDHL1	8.4
Haematopoietic and lymphoid	NUDUL1	8.9
Haematopoietic and lymphoid	OCIAML2	7.9
Haematopoietic and lymphoid	OCIAML3	9
Haematopoietic and lymphoid	OCIAML5	8.9
Haematopoietic and lymphoid	OCILY10	8.6
Haematopoietic and lymphoid	OCILY19	9.2
Haematopoietic and lymphoid	OCILY3	8.5
Haematopoietic and lymphoid	OCIM1	9.5
Haematopoietic and lymphoid	OPM2	8.4
Haematopoietic and lymphoid	P12ICHIKAWA	8.5
Haematopoietic and lymphoid	P31FUJ	8.3
Haematopoietic and lymphoid	P3HR1	8.4
Haematopoietic and lymphoid	PCM6	8.4
Haematopoietic and lymphoid	PEER	8.6
Haematopoietic and lymphoid	PF382	8.6
Haematopoietic and lymphoid	PFEIFFER	8.6
Haematopoietic and lymphoid	PL21	8.5
Haematopoietic and lymphoid	RAJI	8.4
Haematopoietic and lymphoid	RCHACV	8.3
Haematopoietic and lymphoid	REC1	8.8
Haematopoietic and lymphoid	REH	8.6
Haematopoietic and lymphoid	RI1	8.8
Haematopoietic and lymphoid	RL	8.2
Haematopoietic and lymphoid	RPMI8226	8.2
Haematopoietic and lymphoid	RPMI8402	8.8
Haematopoietic and lymphoid	RS411	8.5
Haematopoietic and lymphoid	SEM	8.3
Haematopoietic and lymphoid	SET2	8.7
Haematopoietic and lymphoid	SIGM5	8.5
Haematopoietic and lymphoid	SKM1	8.2
Haematopoietic and lymphoid	SKMM2	8.2
Haematopoietic and lymphoid	SR786	8.5
Haematopoietic and lymphoid	ST486	8.4
Haematopoietic and lymphoid	SUDHL10	8.8
Haematopoietic and lymphoid	SUDHL1	8.8
Haematopoietic and lymphoid	SUDHL4	8.6
Haematopoietic and lymphoid	SUDHL5	8.7
Haematopoietic and lymphoid	SUDHL6	8.8
Haematopoietic and lymphoid	SUDHL8	8.8
Haematopoietic and lymphoid	SUPB15	8.3
Haematopoietic and lymphoid	SUPHD1	8.1
Haematopoietic and lymphoid	SUPM2	8.5
Haematopoietic and lymphoid	SUPT11	8.8
Haematopoietic and lymphoid	SUPT1	8.6
Haematopoietic and lymphoid	TALL1	8.3
Haematopoietic and lymphoid	TF1	8.1
Haematopoietic and lymphoid	THP1	7.8
Haematopoietic and lymphoid	TO175T	8.3
Haematopoietic and lymphoid	TOLEDO	8.2
Haematopoietic and lymphoid	U266B1	7.8
Haematopoietic and lymphoid	U937	8.3
Haematopoietic and lymphoid	UT7	9.3
Haematopoietic and lymphoid	WSUDLCL2	8.8
Kidney	769P	8
Kidney	786O	8.2
Kidney	A498	8.2
Kidney	A704	6.6
Kidney	ACHN	7.6
Kidney	BFTC909	8.2
Kidney	CAKI1	7.8
Kidney	CAKI2	8.1
Kidney	CAL54	7.7
Kidney	KMRC1	7.2
Kidney	KMRC20	7.2
Kidney	KMRC2	7.3
Kidney	KMRC3	7.7
Kidney	OSRC2	7.6
Kidney	RCC10RGB	7.8
Kidney	SNU1272	7.8
Kidney	SNU349	8
Kidney	TUHR10TKB	8.4
Kidney	TUHR14TKB	8.1
Kidney	TUHR4TKB	7.4
Kidney	VMRCRCW	7.7
Kidney	VMRCRCZ	8.2
Large intestine	C2BBE1	7.9
Large intestine	CCK81	8.3
Large intestine	CL11	8.3
Large intestine	CL14	8.2
Large intestine	CL34	7.9
Large intestine	CL40	7.8
Large intestine	COLO205	7.7
Large intestine	COLO320	7.9
Large intestine	COLO678	8.1
Large intestine	CW2	7.6
Large intestine	DLD1	7.9
Large intestine	GP2D	8
Large intestine	HCC56	7.7
Large intestine	HCT116	7.3
Large intestine	HCT15	8.4
Large intestine	HS675T	7.6
Large intestine	HS698T	7.8
Large intestine	HT115	8
Large intestine	HT29	7.6
Large intestine	HT55	8.4
Large intestine	KM12	7.6
Large intestine	LOVO	7.6
Large intestine	LS1034	8.1
Large intestine	LS123	8.6
Large intestine	LS180	7.7
Large intestine	LS411N	7.4
Large intestine	LS513	7.4
Large intestine	MDST8	8.3
Large intestine	NCIH508	7.9
Large intestine	NCIH716	7.9
Large intestine	NCIH747	8
Large intestine	OUMS23	8.1
Large intestine	RCM1	7.8
Large intestine	RKO	7.8
Large intestine	SKCO1	7.8
Large intestine	SNU1040	8.3
Large intestine	SNU1197	8.2
Large intestine	SNU175	8.5
Large intestine	SNU283	8.1
Large intestine	SNU407	8.4
Large intestine	SNU503	8.7
Large intestine	SNU61	7.8
Large intestine	SNU81	8.7
Large intestine	SNUC1	8.3
Large intestine	SNUC2A	8
Large intestine	SNUC4	8
Large intestine	SNUC5	7.6
Large intestine	SW1116	7.9
Large intestine	SW1417	7.7
Large intestine	SW1463	8.3
Large intestine	SW403	7.3
Large intestine	SW480	7.2
Large intestine	SW48	7.9
Large intestine	SW620	8
Large intestine	SW837	7.1
Large intestine	SW948	7.7
Large intestine	T84	8.1
Liver	ALEXANDERCELLS	7.6
Liver	C3A	8.1
Liver	HEP3B217	8.5
Liver	HEPG2	8.2
Liver	HLE	7.8
Liver	HLF	7.9
Liver	HUH1	7.8
Liver	HUH6	8.2
Liver	HUH7	7.7
Liver	JHH1	7.9
Liver	JHH2	8.3
Liver	JHH4	8
Liver	JHH5	8.5
Liver	JHH6	8
Liver	JHH7	8.3
Liver	LI7	7.7
Liver	PLCPRF5	8.4
Liver	SKHEP1	7.6
Liver	SNU182	8.2
Liver	SNU387	8
Liver	SNU398	8.7
Liver	SNU423	8.5
Liver	SNU449	8.2
Liver	SNU475	7.7
Liver	SNU761	8.1
Liver	SNU878	7.6
Liver	SNU886	8.7
Lung	A549	7.5
Lung	ABC1	7.8
Lung	BEN	8
Lung	CAL12T	7.5
Lung	CALU1	8.7
Lung	CALU3	7.7
Lung	CALU6	8.5
Lung	CHAGOK1	8.2
Lung	COLO668	7.7
Lung	COLO699	8.4
Lung	CORL105	8.1
Lung	CORL23	8.1
Lung	CORL24	8
Lung	CORL279	8.5
Lung	CORL311	7.9
Lung	CORL47	8.3
Lung	CORL51	8.5
Lung	CORL88	8.5
Lung	CORL95	8.6
Lung	CPCN	8.4
Lung	DMS114	9.1
Lung	DMS153	8.4
Lung	DMS273	8.3
Lung	DMS454	7.3
Lung	DMS53	7.5
Lung	DMS79	7.7
Lung	DV90	7.8
Lung	EBC1	7.9
Lung	EPLC272H	8.6
Lung	HARA	8.4
Lung	HCC1171	7.5
Lung	HCC1195	8.2
Lung	HCC15	8.2
Lung	HCC2279	8.6
Lung	HCC2935	8.2
Lung	HCC33	7.4
Lung	HCC366	8.1
Lung	HCC4006	7.6
Lung	HCC44	8.5
Lung	HCC78	7.8
Lung	HCC827	7.8
Lung	HCC95	8.4
Lung	HLC1	8.5
Lung	HLFA	7.8
Lung	HS229T	7.7
Lung	HS618T	7.7
Lung	IALM	7.8
Lung	KNS62	7.7
Lung	LC1F	8.6
Lung	LC1SQSF	8.3
Lung	LCLC103H	8
Lung	LCLC97TM1	8.2
Lung	LK2	8
Lung	LOUNH91	8.1
Lung	LU65	7.7
Lung	LU99	7.6
Lung	LUDLU1	7.4
Lung	LXF289	8.5
Lung	MORCPR	9.1
Lung	NCIH1048	7.9
Lung	NCIH1092	8.2
Lung	NCIH1105	8.8
Lung	NCIH1155	7.8
Lung	NCIH1184	7.8
Lung	NCIH1299	8.2
Lung	NCIH1339	8.2
Lung	NCIH1341	8
Lung	NCIH1355	7.9
Lung	NCIH1373	8.1
Lung	NCIH1385	7.8
Lung	NCIH1395	7.8
Lung	NCIH1435	7.5
Lung	NCIH1436	8.4
Lung	NCIH1437	7.4
Lung	NCIH146	8.1
Lung	NCIH1563	8
Lung	NCIH1568	7.8
Lung	NCIH1573	7.9
Lung	NCIH1581	8.2
Lung	NCIH1618	8.7
Lung	NCIH1623	8.2
Lung	NCIH1648	8.1
Lung	NCIH1650	8.3
Lung	NCIH1651	7.9
Lung	NCIH1666	7.7
Lung	NCIH1693	7.2
Lung	NCIH1694	8
Lung	NCIH1703	8.2
Lung	NCIH1734	7.7
Lung	NCIH1755	8.1
Lung	NCIH1781	7.9
Lung	NCIH1792	7.9
Lung	NCIH1793	8.2
Lung	NCIH1836	8.7
Lung	NCIH1838	7.7
Lung	NCIH1869	7.9
Lung	NCIH1876	8
Lung	NCIH1915	7.2
Lung	NCIH1930	8.1
Lung	NCIH1944	7
Lung	NCIH1963	8.2
Lung	NCIH196	8.3
Lung	NCIH1975	8.1
Lung	NCIH2009	7.7
Lung	NCIH2023	7.7
Lung	NCIH2029	8.2
Lung	NCIH2030	8.1
Lung	NCIH2066	8.2
Lung	NCIH2081	8
Lung	NCIH2085	8
Lung	NCIH2087	7.5
Lung	NCIH209	8.2
Lung	NCIH2106	6.4
Lung	NCIH2110	7.6
Lung	NCIH211	8.2
Lung	NCIH2122	7.6
Lung	NCIH2126	7.9
Lung	NCIH2141	8.3
Lung	NCIH2170	7.9
Lung	NCIH2171	8.2
Lung	NCIH2172	8
Lung	NCIH2196	8.2
Lung	NCIH2227	8.2
Lung	NCIH2228	8.3
Lung	NCIH226	8.2
Lung	NCIH2286	8.6
Lung	NCIH2291	8.2
Lung	NCIH2342	7.7
Lung	NCIH2347	7.9
Lung	NCIH23	8.5
Lung	NCIH2405	7.4
Lung	NCIH2444	8
Lung	NCIH292	7.8
Lung	NCIH322	8.3
Lung	NCIH3255	7.8
Lung	NCIH358	7.5
Lung	NCIH441	7.8
Lung	NCIH446	8.4
Lung	NCIH460	7.8
Lung	NCIH510	8.1
Lung	NCIH520	8.6
Lung	NCIH522	8.2
Lung	NCIH524	8
Lung	NCIH526	7.6
Lung	NCIH596	8.1
Lung	NCIH647	7.8
Lung	NCIH650	8
Lung	NCIH661	7.7
Lung	NCIH69	8.1
Lung	NCIH727	8.6
Lung	NCIH810	7.9
Lung	NCIH82	8.8
Lung	NCIH838	7.8
Lung	NCIH841	8.1
Lung	NCIH854	8.3
Lung	NCIH889	8.2
Lung	PC14	8.5
Lung	RERFLCAD1	7.5
Lung	RERFLCAD2	7.5
Lung	RERFLCAI	8.3
Lung	RERFLCKJ	7.8
Lung	RERFLCMS	7.9
Lung	RERFLCSQ1	7.7
Lung	SBC5	7.8
Lung	SCLC21H	8.4
Lung	SHP77	7.9
Lung	SKLU1	7.9
Lung	SKMES1	8
Lung	SQ1	8.5
Lung	SW1271	8.7
Lung	SW1573	7.2
Lung	SW900	8.3
Lung	VMRCLCD	8.2
Lung	VMRCLCP	8.4
Oesophagus	COLO680N	7.6
Oesophagus	ECGI10	8.3
Oesophagus	KYSE140	8.6
Oesophagus	KYSE150	8.2
Oesophagus	KYSE180	9.1
Oesophagus	KYSE270	8.6
Oesophagus	KYSE30	8.1
Oesophagus	KYSE410	8.4
Oesophagus	KYSE450	8.4
Oesophagus	KYSE510	7.7
Oesophagus	KYSE520	8.6
Oesophagus	KYSE70	8.7
Oesophagus	OE19	8.4
Oesophagus	OE33	7
Oesophagus	TE10	8.4
Oesophagus	TE11	8.2
Oesophagus	TE14	8.2
Oesophagus	TE15	7.7
Oesophagus	TE1	7.7
Oesophagus	TE4	8.2
Oesophagus	TE5	7.4
Oesophagus	TE6	8.2
Oesophagus	TE8	8.3
Oesophagus	TE9	8.2
Oesophagus	TT	8.4
Ovary	59M	8.1
Ovary	A2780	8.4
Ovary	CAOV3	7.7
Ovary	CAOV4	7.3
Ovary	COLO704	8.4
Ovary	COV318	8.5
Ovary	COV362	8
Ovary	COV434	8
Ovary	COV504	7.3
Ovary	COV644	7.5
Ovary	EFO21	9.1
Ovary	EFO27	8
Ovary	ES2	7.9
Ovary	FUOV1	8.1
Ovary	HEYA8	7.6
Ovary	HS571T	8
Ovary	IGROV1	8.2
Ovary	JHOC5	7.7
Ovary	JHOM1	7.7
Ovary	JHOM2B	7.7
Ovary	JHOS2	7.8
Ovary	JHOS4	8.6
Ovary	KURAMOCHI	8
Ovary	MCAS	8
Ovary	NIHOVCAR3	7.8
Ovary	OAW28	8.5
Ovary	OAW42	8.4
Ovary	OC314	7.8
Ovary	OC316	7.7
Ovary	ONCODG1	7.5
Ovary	OV56	8
Ovary	OV7	8.3
Ovary	OV90	8.3
Ovary	OVCAR4	8.3
Ovary	OVCAR8	7.7
Ovary	OVISE	8.1
Ovary	OVK18	8.1
Ovary	OVKATE	7.6
Ovary	OVMANA	7.7
Ovary	OVSAHO	7.9
Ovary	OVTOKO	7.7
Ovary	RMGI	8.5
Ovary	RMUGS	7.7
Ovary	SKOV3	8.4
Ovary	SNU119	8.4
Ovary	SNU840	7.8
Ovary	SNU8	7.6
Ovary	TOV112D	8.5
Ovary	TOV21G	7.9
Ovary	TYKNU	7.8
Pancreas	ASPC1	7.5
Pancreas	BXPC3	7.7
Pancreas	CAPAN1	8.2
Pancreas	CAPAN2	9
Pancreas	CFPAC1	8
Pancreas	DANG	8.3
Pancreas	HPAC	8.1
Pancreas	HPAFII	7.6
Pancreas	HS766T	7.9
Pancreas	HUPT3	8.8
Pancreas	HUPT4	8.1
Pancreas	KCIMOH1	7.5
Pancreas	KLM1	7.8
Pancreas	KP2	8
Pancreas	KP3	7.2
Pancreas	KP4	8.1
Pancreas	L33	7.9
Pancreas	MIAPACA2	9.1
Pancreas	PANC0203	8.1
Pancreas	PANC0213	8.5
Pancreas	PANC0327	8.4
Pancreas	PANC0403	7.4
Pancreas	PANC0504	8
Pancreas	PANC0813	8.2
Pancreas	PANC1005	8.4
Pancreas	PANC1	8.1
Pancreas	PATU8902	8.2
Pancreas	PATU8988S	7.5
Pancreas	PATU8988T	8.1
Pancreas	PK1	7.6
Pancreas	PK45H	7.9
Pancreas	PK59	9.3
Pancreas	PL45	8.3
Pancreas	PSN1	8.2
Pancreas	QGP1	8.2
Pancreas	SNU213	7.6
Pancreas	SNU324	8
Pancreas	SNU410	8.3
Pancreas	SU8686	7.7
Pancreas	SUIT2	7.6
Pancreas	SW1990	7.6
Pancreas	T3M4	7.5
Pancreas	TCCPAN2	8.2
Pancreas	YAPC	8.3
Pleura	ACCMESO1	6.9
Pleura	DM3	7.5
Pleura	ISTMES1	8.3
Pleura	ISTMES2	8.5
Pleura	JL1	8.3
Pleura	MPP89	7.7
Pleura	MSTO211H	8
Pleura	NCIH2052	7.6
Pleura	NCIH2452	8.4
Pleura	NCIH28	8
Prostate	22RV1	7.7
Prostate	DU145	7.3
Prostate	LNCAPCLONEFGC	7.8
Prostate	MDAPCA2B	7.8
Prostate	NCIH660	8.4
Prostate	PC3	8.1
Prostate	VCAP	7.9
Salivary gland	A253	7.8
Salivary gland	YD15	8
Skin	A101D	8.1
Skin	A2058	8.5
Skin	A375	8.8
Skin	C32	7.9
Skin	CHL1	7.9
Skin	CJM	8.4
Skin	COLO679	8.1
Skin	COLO741	8.4
Skin	COLO783	8.3
Skin	COLO792	7.9
Skin	COLO800	8.6
Skin	COLO818	8
Skin	COLO829	8.2
Skin	COLO849	8.7
Skin	G361	7.6
Skin	GRM	9.2
Skin	HMCB	8.1
Skin	HS294T	8.2
Skin	HS600T	7.9
Skin	HS688AT	7.9
Skin	HS695T	8.3
Skin	HS839T	8.1
Skin	HS852T	9
Skin	HS895T	7.5
Skin	HS934T	8.1
Skin	HS936T	8.1
Skin	HS939T	8
Skin	HS940T	8.1
Skin	HS944T	8.6
Skin	HT144	8.5
Skin	IGR1	8.1
Skin	IGR37	8.4
Skin	IGR39	8.5
Skin	IPC298	8.2
Skin	K029AX	8.1
Skin	LOXIMVI	8.3
Skin	MALME3M	7.7
Skin	MDAMB435S	8
Skin	MELHO	7.9
Skin	MELJUSO	8
Skin	MEWO	7.5
Skin	RPMI7951	8
Skin	RVH421	7.8
Skin	SH4	7.8
Skin	SKMEL1	7.8
Skin	SKMEL24	8
Skin	SKMEL28	8
Skin	SKMEL2	7.9
Skin	SKMEL30	7.8
Skin	SKMEL31	8.2
Skin	SKMEL3	7.8
Skin	SKMEL5	8.3
Skin	UACC257	8
Skin	UACC62	8.4
Skin	WM115	8.2
Skin	WM1799	7.8
Skin	WM2664	8.3
Skin	WM793	8.8
Skin	WM88	7.7
Skin	WM983B	7.9
Small intestine	HUTU80	8.7
Soft tissue	A204	8.1
Soft tissue	G401	8.5
Soft tissue	G402	8.1
Soft tissue	GCT	8.5
Soft tissue	HS729	9
Soft tissue	HT1080	8.3
Soft tissue	KYM1	8.2
Soft tissue	MESSA	8.5
Soft tissue	RD	8.4
Soft tissue	RH30	8.8
Soft tissue	RH41	7.9
Soft tissue	RKN	8.3
Soft tissue	S117	8.6
Soft tissue	SJRH30	8.9
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	8.1
Soft tissue	TE125T	7.7
Soft tissue	TE159T	8.1
Soft tissue	TE441T	8.7
Soft tissue	TE617T	8.4
Stomach	2313287	8.3
Stomach	AGS	7.8
Stomach	AZ521	8.6
Stomach	ECC10	8.4
Stomach	ECC12	8.5
Stomach	FU97	9.3
Stomach	GCIY	6.8
Stomach	GSS	9.9
Stomach	GSU	7.8
Stomach	HGC27	8.4
Stomach	HS746T	8.2
Stomach	HUG1N	7.5
Stomach	IM95	7.7
Stomach	KATOIII	7.5
Stomach	KE39	7.3
Stomach	LMSU	8.1
Stomach	MKN1	7.8
Stomach	MKN45	8.2
Stomach	MKN74	8.5
Stomach	MKN7	8.1
Stomach	NCCSTCK140	8.3
Stomach	NCIN87	8.3
Stomach	NUGC2	8.5
Stomach	NUGC3	7.9
Stomach	NUGC4	7.7
Stomach	OCUM1	7.9
Stomach	RERFGC1B	8.2
Stomach	SH10TC	7.6
Stomach	SNU16	8.2
Stomach	SNU1	8.1
Stomach	SNU216	8.5
Stomach	SNU520	7.4
Stomach	SNU5	8
Stomach	SNU601	8.3
Stomach	SNU620	7.9
Stomach	SNU668	9
Stomach	SNU719	8
Stomach	TGBC11TKB	8.2
Thyroid	8305C	7.9
Thyroid	8505C	8.2
Thyroid	BCPAP	8.4
Thyroid	BHT101	7.8
Thyroid	CAL62	8.4
Thyroid	CGTHW1	9.1
Thyroid	FTC133	8.5
Thyroid	FTC238	8.1
Thyroid	ML1	7.1
Thyroid	SW579	9.6
Thyroid	TT2609C02	8.1
Thyroid	TT	7.7
Upper aerodigestive tract	BHY	8.1
Upper aerodigestive tract	BICR16	8.2
Upper aerodigestive tract	BICR18	7.8
Upper aerodigestive tract	BICR22	8.2
Upper aerodigestive tract	BICR31	7.6
Upper aerodigestive tract	BICR56	8
Upper aerodigestive tract	BICR6	8.3
Upper aerodigestive tract	CAL27	8.1
Upper aerodigestive tract	CAL33	8.3
Upper aerodigestive tract	DETROIT562	8
Upper aerodigestive tract	FADU	7.7
Upper aerodigestive tract	HS840T	7.8
Upper aerodigestive tract	HSC2	8.3
Upper aerodigestive tract	HSC3	7.3
Upper aerodigestive tract	HSC4	7.7
Upper aerodigestive tract	PECAPJ15	8
Upper aerodigestive tract	PECAPJ34CLONEC12	8.4
Upper aerodigestive tract	PECAPJ41CLONED2	8.2
Upper aerodigestive tract	PECAPJ49	8.5
Upper aerodigestive tract	SCC15	7.6
Upper aerodigestive tract	SCC25	8.2
Upper aerodigestive tract	SCC4	8.3
Upper aerodigestive tract	SCC9	7.6
Upper aerodigestive tract	SNU1076	7.3
Upper aerodigestive tract	SNU1214	7.8
Upper aerodigestive tract	SNU46	9.2
Upper aerodigestive tract	SNU899	7.7
Upper aerodigestive tract	YD10B	7.9
Upper aerodigestive tract	YD38	8.5
Upper aerodigestive tract	YD8	8.2
Urinary tract	5637	8.5
Urinary tract	639V	8.8
Urinary tract	647V	8.2
Urinary tract	BC3C	8.3
Urinary tract	BFTC905	8.2
Urinary tract	CAL29	7.6
Urinary tract	HS172T	7.3
Urinary tract	HT1197	7.7
Urinary tract	HT1376	8.1
Urinary tract	J82	8.5
Urinary tract	JMSU1	8.7
Urinary tract	KMBC2	8
Urinary tract	KU1919	8.1
Urinary tract	RT11284	8.2
Urinary tract	RT112	8.2
Urinary tract	RT4	8.1
Urinary tract	SCABER	8
Urinary tract	SW1710	7.8
Urinary tract	SW780	7.6
Urinary tract	T24	8.4
Urinary tract	TCCSUP	7.1
Urinary tract	UMUC1	8.5
Urinary tract	UMUC3	7.9
Urinary tract	VMCUB1	7.7

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	22.6
Adrenal gland	18.5
Appendix	31.9
Bone marrow	15.6
Breast	10
Cerebral cortex	33.3
Cervix, uterine	19.7
Colon	12.2
Duodenum	15.4
Endometrium	26.3
Epididymis	10
Esophagus	17.5
Fallopian tube	21
Gallbladder	20.5
Heart muscle	10.2
Kidney	12.9
Liver	9.9
Lung	22.2
Lymph node	24.7
Ovary	24.2
Pancreas	5.6
Parathyroid gland	24
Placenta	41.6
Prostate	18.3
Rectum	9.4
Salivary gland	8.4
Seminal vesicle	19.1
Skeletal muscle	13.2
Skin	22.8
Small intestine	18.8
Smooth muscle	20.2
Spleen	33.9
Stomach	16.4
Testis	33
Thyroid gland	20.5
Tonsil	15.2
Urinary bladder	15

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27388964	overexpression	Glioblastoma	BRD2 and BRD4, members of the BET family, are significantly increased in glioblastoma multiforme (GBM), the most common primary adult brain cancer.
28681984	overexpression	Gastric Carcinoma	Expression analyses in both small and large cohort of sample show that BRD4 is highly expressed in gastric cancer tissues/cells when compared with the adjacent non-tumor tissues/normal cells.
28481868	aberrant expression	Gastric Carcinoma	Here, we report that the stability and functions of BRD4 are positively regulated by prolyl isomerase PIN1 in gastric cancer cells.
28391274	overexpression	Renal Cell Carcinoma	BRD4 is significantly overexpressed in RCC, and is related to tumor stage and lymph node metastasis.
27223260	Overexpression	Prostate Carcinoma	Gene expression profile analysis shows some ERG-BRD4 co-target genes are upregulated in CRPC compared to hormone-nave counterparts.
27081696	Overexpression	Hepatocellular Carcinoma	BRD4 was overexpressed in three different large cohort of hepatocellular carcinoma (HCC) patients as well as in liver cancer cell lines.
26939702	Overexpression	Bladder Carcinoma	We found that BRD4 was significantly overexpressed in bladder cancer cells and tissues.
26840017	Overexpression	Non-Small Cell Lung Cancer	Here, we found that BRD4 expression was significantly upregulated in NSCLC tissues and NSCLC cell lines with higher invasion and metastasis potentials.
26807235	Overexpression (Copy number gain)	Ovarian Carcinoma	Our analysis using clinical and genomic data from the TCGA ovarian carcinoma samples revealed that somatic amplification of BRD4 (observed in 12% of the cases) was correlated with increased BRD4 mRNA levels and is significantly associated with worse overall and progression-free survival compared to wild-type cases.
25892415	Overexpression; copy number gain	Ovarian Carcinoma	CCNE1 (19q12) and BRD4 (19p13.1) amplification/overexpression was found in 19/33 (57.5%) of non-BRCAness cases.
25120803	Overexpression	Bladder Carcinoma	Up-regulated expression of BRD4 mRNA and protein was observed in the majority of UCBs by qRT-PCR and Western blot when compared with their paired normal bladder tissues.
23950209	Overexpression	Melanoma	Here, we report that BRD4, a BET family member, is significantly upregulated in primary and metastatic melanoma tissues compared with melanocytes and nevi.
22120039	Underexpression (hypermethylation)	Colon Carcinoma	Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors.

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.428	2.22e-19	28.5	53.2	18.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.539	3.45e-82	19.1	60.1	20.8	Neutral
CESC	Cervical and endocervical cancers	292	0.411	2.6e-13	26.4	60.6	13	Neutral
COAD	Colon adenocarcinoma	449	0.286	6.34e-10	8.9	74.4	16.7	Neutral
ESCA	Esophageal carcinoma	183	0.613	3.1e-20	33.9	47.5	18.6	Loss
GBM	Glioblastoma multiforme	147	0.376	2.7e-06	8.2	58.5	33.3	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.412	1.56e-22	18.9	67.1	14	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.026	0.552	2.5	88.4	9.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.186	0.00156	5.2	92.7	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.379	4.64e-07	1.8	95.2	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.313	3.72e-13	2.9	75.2	21.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.284	3.52e-08	15.9	65.7	18.4	Neutral
LUAD	Lung adenocarcinoma	512	0.285	5.38e-11	49.6	45.5	4.9	Loss
LUSC	Lung squamous cell carcinoma	498	0.524	2.15e-36	33.1	43	23.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.795	1.47e-66	18.7	28.7	52.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.216	0.00385	12.4	78.5	9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.356	3.37e-06	0.6	87	12.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.171	0.000138	4.1	93.1	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.174	0.0255	15.2	64	20.7	Neutral
SARC	Sarcoma	255	0.539	1.28e-20	9.4	52.2	38.4	Gain
SKCM	Skin Cutaneous Melanoma	367	0.284	3.07e-08	21.8	61.9	16.3	Neutral
STAD	Stomach adenocarcinoma	413	0.391	1.64e-16	27.6	61.5	10.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.344	1.62e-05	31.3	44	24.7	Neutral
THCA	Thyroid carcinoma	497	0.119	0.00808	1.2	97.2	1.6	Neutral
THYM	Thymoma	119	0.072	0.438	2.5	95	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.404	1.9e-22	8.6	73.7	17.7	Neutral

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.143	0.00324	17	408	-0.227	6.47e-06	Decreased
BRCA	Breast invasive carcinoma	-0.244	3.81e-13	83	785	-0.09	5.29e-16	NS/NA
CESC	Cervical and endocervical cancers	-0.31	3.23e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	0.014	0.803	19	297	0.003	0.271	NS/NA
ESCA	Esophageal carcinoma	-0.222	0.0019	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.189	0.132	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.177	3.35e-05	20	522	0.046	0.026	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.042	0.434	24	319	0.08	3.81e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.091	0.119	23	275	0.08	3.75e-10	NS/NA
LAML	Acute Myeloid Leukemia	0.047	0.545	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.208	1.46e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.196	5.89e-05	41	373	-0.036	0.42	NS/NA
LUAD	Lung adenocarcinoma	-0.075	0.0999	21	456	-0.006	0.126	NS/NA
LUSC	Lung squamous cell carcinoma	-0.344	8.57e-12	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.267	0.493	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.059	0.427	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.197	0.00709	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.039	0.368	35	498	0.037	2e-06	NS/NA
READ	Rectum adenocarcinoma	-0.133	0.185	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.329	5.77e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.028	0.55	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	0.003	0.955	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.441	1.22e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.061	0.149	50	509	0.031	0.00211	NS/NA
THYM	Thymoma	-0.274	0.00237	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.197	1.92e-05	34	431	0.031	0.843	NS/NA

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA)

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Cancer	Full Name	# Sample	Median (abundance)	MAD (abundance)
BRCA	Breast invasive carcinoma	892	-0.002	0.327
COAD	Colon adenocarcinoma	362	-0.027	0.256
GBM	Glioblastoma multiforme	244	-0.088	0.352
LIHC	Liver hepatocellular carcinoma	184	-0.038	0.38
OV	Ovarian serous cystadenocarcinoma	436	-0.024	0.386
READ	Rectum adenocarcinoma	131	-0.026	0.252
UCEC	Uterine Corpus Endometrial Carcinoma	440	-0.035	0.255

> The Human Protein Atlas (HPA)

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Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.758	NS	24476821
BRCA	Breast invasive carcinoma	521	4.64e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00689	Significant	22810696
GBM	Glioblastoma multiforme	157	4.21e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.67e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0744	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00171	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.558	NS	25079552
LUSC	Lung squamous cell carcinoma	178	6.04e-08	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00956	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00766	Significant	26544944
READ	Rectum adenocarcinoma	67	0.185	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00408	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0334	Significant	25079317
THCA	Thyroid carcinoma	391	0.124	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.19e-08	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.316	0.182	NS
BRCA	Breast invasive carcinoma	1079	0.698	0.113	NS
CESC	Cervical and endocervical cancers	291	0.886	0.748	NS
COAD	Colon adenocarcinoma	439	1.515	0.121	NS
ESCA	Esophageal carcinoma	184	0.931	0.82	NS
GBM	Glioblastoma multiforme	158	1.128	0.638	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.958	0.825	NS
KIRC	Kidney renal clear cell carcinoma	531	1.498	0.039	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	3.297	0.007	Shorter
LAML	Acute Myeloid Leukemia	149	1.319	0.322	NS
LGG	Brain Lower Grade Glioma	511	2.087	0.00596	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.882	0.591	NS
LUAD	Lung adenocarcinoma	502	1.318	0.16	NS
LUSC	Lung squamous cell carcinoma	494	0.863	0.443	NS
OV	Ovarian serous cystadenocarcinoma	303	1.324	0.181	NS
PAAD	Pancreatic adenocarcinoma	177	0.899	0.717	NS
PCPG	Pheochromocytoma and Paraganglioma	179	533983343.771	0.0599	NS
PRAD	Prostate adenocarcinoma	497	4.63	0.15	NS
READ	Rectum adenocarcinoma	159	1.311	0.661	NS
SARC	Sarcoma	259	1.197	0.533	NS
SKCM	Skin Cutaneous Melanoma	459	1.899	0.001	Shorter
STAD	Stomach adenocarcinoma	388	0.935	0.754	NS
TGCT	Testicular Germ Cell Tumors	134	643421062.669	0.299	NS
THCA	Thyroid carcinoma	500	1.114	0.872	NS
THYM	Thymoma	119	0.387	0.396	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.041	0.892	NS

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.04	0.425	NS
BRCA	Breast invasive carcinoma	1071	-0.035	0.247	NS
CESC	Cervical and endocervical cancers	167	0.073	0.346	NS
COAD	Colon adenocarcinoma	445	0.065	0.171	NS
ESCA	Esophageal carcinoma	162	-0.125	0.112	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.05	0.289	NS
KIRC	Kidney renal clear cell carcinoma	531	0.032	0.459	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.202	0.00103	Higher
LIHC	Liver hepatocellular carcinoma	347	0.03	0.575	NS
LUAD	Lung adenocarcinoma	507	0.059	0.187	NS
LUSC	Lung squamous cell carcinoma	497	0.016	0.717	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.08	0.167	NS
PAAD	Pancreatic adenocarcinoma	176	0.073	0.333	NS
READ	Rectum adenocarcinoma	156	0.005	0.947	NS
SKCM	Skin Cutaneous Melanoma	410	-0.11	0.0261	Lower
STAD	Stomach adenocarcinoma	392	0.032	0.528	NS
TGCT	Testicular Germ Cell Tumors	81	-0.15	0.182	NS
THCA	Thyroid carcinoma	499	0.035	0.43	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.094	0.0355	Higher

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.035	0.56	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.024	0.586	NS
KIRC	Kidney renal clear cell carcinoma	525	0.07	0.108	NS
LGG	Brain Lower Grade Glioma	514	0.16	0.000265	Higher
LIHC	Liver hepatocellular carcinoma	366	0.004	0.935	NS
OV	Ovarian serous cystadenocarcinoma	296	0.055	0.35	NS
PAAD	Pancreatic adenocarcinoma	176	0.033	0.659	NS
STAD	Stomach adenocarcinoma	406	-0.043	0.391	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.134	0.00194	Higher

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for BRD4.

Summary
Symbol	BRD4
Name	bromodomain containing 4
Aliases	HUNKI; HUNK1; chromosome-associated protein; bromodomain-containing 4; Protein HUNK1; Bromodomain-containing ......
Location	19p13.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28681984	Gastric Carcinoma	downstream	c-MYC	positive regulation	We also find a positive correlation between the expression of BRD4 and c-MYC in patient samples. The repression of BRD4 by siRNAs leads to the down-regulation of c-MYC in gastric cancer cells. Chromatin immunoprecipitation-qPCR and luciferase assays show that BRD4 binds to and coordinately activates c-MYC promoter, indicating that c-MYC is transcriptional target of BRD4 and BRD4 regulates its basal expression.
28481868	Gastric Carcinoma	upstream	PIN1	positive regulation	Here, we report that the stability and functions of BRD4 are positively regulated by prolyl isomerase PIN1 in gastric cancer cells.
28391274	Renal Cell Carcinoma	downstream	BCL2; C-MYC; BAX; cleaved CASP3	positive regulation; positive regulation; negative regulation; negative regulation	Inhibition of BRD4 decreased BCL2 and C-MYC expression while increased BAX and cleaved caspase3 expression, and strikingly diminished the recruitment of BRD4 to BCL2 promoter.
24655834	NUT Midline Carcinoma	partner	NUT	Fusion	Cytogenetic and fluorescence in situ hybridization analyses revealed a t(15;19) and BRD4-NUT gene rearrangement.