CR2Cancer

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain

Function

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	#	#	14966270

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030522 intracellular receptor signaling pathway GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation
Molecular Function	GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004887 thyroid hormone receptor activity GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000812 Swr1 complex GO:0031248 protein acetyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0097346 INO80-type complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4616127	c.2465delA	p.E822fs*58	Deletion - Frameshift	Large_intestine
COSM351125	c.2680C>G	p.L894V	Substitution - Missense	Lung
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Breast
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM1158531	c.2035C>G	p.Q679E	Substitution - Missense	Lung
COSM3608883	c.1877C>G	p.A626G	Substitution - Missense	Skin
COSM5720372	c.3665G>A	p.G1222E	Substitution - Missense	Skin
COSM4905426	c.1173G>A	p.K391K	Substitution - coding silent	Skin
COSM308641	c.2250-3_2250-2insT	p.?	Unknown	Lung
COSM5001560	c.1732G>T	p.A578S	Substitution - Missense	Pancreas
COSM5962271	c.595C>G	p.P199A	Substitution - Missense	Breast
COSM1184909	c.161G>A	p.R54H	Substitution - Missense	Large_intestine
COSM1310569	c.2703G>C	p.W901C	Substitution - Missense	Urinary_tract
COSM214010	c.361C>T	p.R121W	Substitution - Missense	Bone
COSM1660797	c.1736C>T	p.S579F	Substitution - Missense	Kidney
COSM481986	c.701T>A	p.L234Q	Substitution - Missense	Kidney
COSM3393154	c.2767G>T	p.E923*	Substitution - Nonsense	Pancreas
COSM1184904	c.2500G>T	p.D834Y	Substitution - Missense	Large_intestine
COSM1184908	c.2748C>A	p.S916R	Substitution - Missense	Large_intestine
COSM318944	c.3450A>T	p.L1150F	Substitution - Missense	Lung
COSM5344816	c.2532+7C>T	p.?	Unknown	Large_intestine
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Urinary_tract
COSM1184902	c.2491C>T	p.R831*	Substitution - Nonsense	Large_intestine
COSM3608889	c.1419C>T	p.L473L	Substitution - coding silent	Skin
COSM4924490	c.3125A>G	p.E1042G	Substitution - Missense	Liver
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM1184915	c.292C>T	p.R98W	Substitution - Missense	Large_intestine
COSM4954034	c.1990G>T	p.V664L	Substitution - Missense	Liver
COSM149917	c.2428-4A>G	p.?	Unknown	Stomach
COSM1184913	c.656A>C	p.E219A	Substitution - Missense	Large_intestine
COSM5622952	c.1157C>T	p.P386L	Substitution - Missense	Oesophagus
COSM1184906	c.183A>C	p.Q61H	Substitution - Missense	Large_intestine
COSM1753987	c.1282G>T	p.D428Y	Substitution - Missense	Urinary_tract
COSM4572941	c.698T>A	p.L233H	Substitution - Missense	Skin
COSM1619520	c.2218A>G	p.I740V	Substitution - Missense	Liver
COSM3428934	c.3641G>T	p.R1214I	Substitution - Missense	Large_intestine
COSM5002541	c.1033G>T	p.V345L	Substitution - Missense	Pancreas
COSM3608875	c.3351G>A	p.K1117K	Substitution - coding silent	Skin
COSM4954034	c.1990G>T	p.V664L	Substitution - Missense	Liver
COSM1658921	c.2242G>A	p.V748M	Substitution - Missense	Salivary_gland
COSM3608880	c.2617C>T	p.H873Y	Substitution - Missense	Skin
COSM1176695	c.1591G>A	p.A531T	Substitution - Missense	Endometrium
COSM589516	c.3488G>A	p.R1163H	Substitution - Missense	Stomach
COSM1246221	c.2299C>T	p.R767*	Substitution - Nonsense	Stomach
COSM5720372	c.3665G>A	p.G1222E	Substitution - Missense	Skin
COSM4483944	c.2750C>T	p.P917L	Substitution - Missense	Skin
COSM1061232	c.3113G>A	p.S1038N	Substitution - Missense	Endometrium
COSM1061245	c.942G>A	p.A314A	Substitution - coding silent	Endometrium
COSM215958	c.533G>A	p.R178Q	Substitution - Missense	Central_nervous_system
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM5471959	c.2537G>A	p.S846N	Substitution - Missense	Large_intestine
COSM5720372	c.3665G>A	p.G1222E	Substitution - Missense	Skin
COSM4159432	c.1404C>A	p.D468E	Substitution - Missense	Thyroid
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM4666124	c.2910C>T	p.G970G	Substitution - coding silent	Large_intestine
COSM1619518	c.2221G>A	p.A741T	Substitution - Missense	Liver
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Soft_tissue
COSM1238319	c.2405G>A	p.R802Q	Substitution - Missense	Oesophagus
COSM3608879	c.2997G>A	p.E999E	Substitution - coding silent	Skin
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Liver
COSM3850368	c.2854G>A	p.E952K	Substitution - Missense	Stomach
COSM1061238	c.2321G>A	p.R774H	Substitution - Missense	Endometrium
COSM481983	c.2885T>C	p.I962T	Substitution - Missense	Kidney
COSM340233	c.3369G>T	p.R1123S	Substitution - Missense	Lung
COSM3850366	c.3130C>T	p.Q1044*	Substitution - Nonsense	Stomach
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM268763	c.399C>G	p.H133Q	Substitution - Missense	Large_intestine
COSM1061229	c.3464G>T	p.R1155I	Substitution - Missense	Endometrium
COSM3608885	c.1787C>T	p.P596L	Substitution - Missense	Skin
COSM5758593	c.2222C>A	p.A741E	Substitution - Missense	Bone
COSM1246219	c.2250-2A>T	p.?	Unknown	Oesophagus
COSM1671894	c.445A>C	p.K149Q	Substitution - Missense	Large_intestine
COSM4853032	c.1156C>G	p.P386A	Substitution - Missense	Cervix
COSM4914183	c.3331A>G	p.T1111A	Substitution - Missense	Liver
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM481985	c.858T>A	p.T286T	Substitution - coding silent	Kidney
COSM1580110	c.1792G>A	p.E598K	Substitution - Missense	Central_nervous_system
COSM3608887	c.1775C>T	p.P592L	Substitution - Missense	Skin
COSM589516	c.3488G>A	p.R1163H	Substitution - Missense	Upper_aerodigestive_tract
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Thyroid
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Large_intestine
COSM1495903	c.318A>C	p.E106D	Substitution - Missense	Kidney
COSM3236970	c.1610C>T	p.P537L	Substitution - Missense	Large_intestine
COSM1292022	c.3615+1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM159412	c.1105G>T	p.E369*	Substitution - Nonsense	Breast
COSM5628966	c.356A>G	p.Y119C	Substitution - Missense	Oesophagus
COSM5402174	c.635C>T	p.T212I	Substitution - Missense	Skin
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM5957739	c.847_848insG	p.A283fs*9	Insertion - Frameshift	Thyroid
COSM420410	c.410G>C	p.R137T	Substitution - Missense	Urinary_tract
COSM3850365	c.3616G>A	p.V1206I	Substitution - Missense	Stomach
COSM366544	c.3203A>T	p.E1068V	Substitution - Missense	Lung
COSM4585419	c.1005A>G	p.Q335Q	Substitution - coding silent	Bone
COSM5996162	c.3701T>C	p.V1234A	Substitution - Missense	Prostate
COSM5720372	c.3665G>A	p.G1222E	Substitution - Missense	Skin
COSM376842	c.3200_3201GC>AT	p.G1067>?	Complex	Lung
COSM1184911	c.118G>A	p.V40I	Substitution - Missense	Large_intestine
COSM3365845	c.2081C>T	p.S694L	Substitution - Missense	Kidney
COSM1433316	c.2979C>A	p.L993L	Substitution - coding silent	Large_intestine
COSM1246223	c.206C>T	p.S69L	Substitution - Missense	Oesophagus
COSM3608891	c.1372C>T	p.P458S	Substitution - Missense	Skin
COSM1753985	c.1447G>A	p.E483K	Substitution - Missense	Urinary_tract
COSM1642601	c.533_534insC	p.R179fs*19	Insertion - Frameshift	Stomach
COSM1246219	c.2250-2A>T	p.?	Unknown	Kidney
COSM332444	c.534G>T	p.R178R	Substitution - coding silent	Lung
COSM1246225	c.2912G>T	p.C971F	Substitution - Missense	Oesophagus
COSM3850367	c.3087T>C	p.C1029C	Substitution - coding silent	Stomach
COSM1061237	c.2404C>T	p.R802*	Substitution - Nonsense	Endometrium
COSM1671892	c.2313A>C	p.E771D	Substitution - Missense	Large_intestine
COSM298053	c.557G>A	p.R186H	Substitution - Missense	Large_intestine
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM1619518	c.2221G>A	p.A741T	Substitution - Missense	Liver
COSM1633952	c.2416G>T	p.E806*	Substitution - Nonsense	Liver
COSM5902727	c.2968G>A	p.E990K	Substitution - Missense	Skin
COSM3850373	c.1439T>C	p.V480A	Substitution - Missense	Stomach
COSM5952799	c.2591G>A	p.W864*	Substitution - Nonsense	Oesophagus
COSM1328267	c.2092G>T	p.V698F	Substitution - Missense	Ovary
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1186837	c.313G>T	p.V105F	Substitution - Missense	Lung
COSM2157434	c.3464G>A	p.R1155K	Substitution - Missense	Central_nervous_system
COSM3236952	c.2313A>G	p.E771E	Substitution - coding silent	Upper_aerodigestive_tract
COSM1158531	c.2035C>G	p.Q679E	Substitution - Missense	Pancreas
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Liver
COSM1718169	c.963T>G	p.A321A	Substitution - coding silent	Skin
COSM4911311	c.1092C>T	p.I364I	Substitution - coding silent	Liver
COSM3236923	c.3338_3341delTGCC	p.L1113fs*5	Deletion - Frameshift	Upper_aerodigestive_tract
COSM1633954	c.2266A>G	p.T756A	Substitution - Missense	Liver
COSM3946869	c.3398C>T	p.S1133L	Substitution - Missense	Lung
COSM4795262	c.1480G>A	p.G494R	Substitution - Missense	Liver
COSM3428935	c.3539T>G	p.V1180G	Substitution - Missense	Large_intestine
COSM5560538	c.1821G>C	p.M607I	Substitution - Missense	Prostate
COSM1633954	c.2266A>G	p.T756A	Substitution - Missense	Liver
COSM1061240	c.2110G>T	p.E704*	Substitution - Nonsense	Endometrium
COSM481984	c.2586C>T	p.H862H	Substitution - coding silent	Kidney
COSM3850375	c.1227A>C	p.E409D	Substitution - Missense	Stomach
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM3608876	c.3279G>A	p.L1093L	Substitution - coding silent	Skin
COSM3236946	c.2352A>T	p.V784V	Substitution - coding silent	Upper_aerodigestive_tract
COSM1061231	c.3266C>T	p.T1089I	Substitution - Missense	Endometrium
COSM1671894	c.445A>C	p.K149Q	Substitution - Missense	Large_intestine
COSM1671891	c.3194C>T	p.P1065L	Substitution - Missense	Large_intestine
COSM1061239	c.2308G>A	p.A770T	Substitution - Missense	Endometrium
COSM1619517	c.2893A>G	p.N965D	Substitution - Missense	Liver
COSM1433329	c.532delC	p.R178fs*6	Deletion - Frameshift	Large_intestine
COSM1184909	c.161G>A	p.R54H	Substitution - Missense	Stomach
COSM329178	c.3237C>T	p.P1079P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1061243	c.1759T>C	p.S587P	Substitution - Missense	Endometrium
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM1671892	c.2313A>C	p.E771D	Substitution - Missense	Large_intestine
COSM149916	c.3120+8A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1433329	c.532delC	p.R178fs*6	Deletion - Frameshift	Large_intestine
COSM4967084	c.2429A>T	p.Q810L	Substitution - Missense	Central_nervous_system
COSM4489418	c.3471C>T	p.L1157L	Substitution - coding silent	Skin
COSM2157434	c.3464G>A	p.R1155K	Substitution - Missense	Central_nervous_system
COSM5601106	c.2686C>T	p.L896F	Substitution - Missense	Skin
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM3993987	c.3589C>T	p.R1197W	Substitution - Missense	Kidney
COSM3236920	c.3484A>C	p.I1162L	Substitution - Missense	Large_intestine
COSM3826830	c.2053G>A	p.D685N	Substitution - Missense	Breast
COSM1642603	c.440+1G>A	p.?	Unknown	Stomach
COSM274165	c.1822T>C	p.S608P	Substitution - Missense	Large_intestine
COSM1619520	c.2218A>G	p.I740V	Substitution - Missense	Liver
COSM5618339	c.1469C>T	p.T490M	Substitution - Missense	Breast
COSM1061246	c.244C>T	p.R82*	Substitution - Nonsense	Endometrium
COSM1061236	c.2464G>A	p.E822K	Substitution - Missense	Endometrium
COSM5450061	c.711C>T	p.G237G	Substitution - coding silent	Large_intestine
COSM4999034	c.2545A>G	p.M849V	Substitution - Missense	Pancreas
COSM1328265	c.1566C>T	p.A522A	Substitution - coding silent	Ovary
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM149916	c.3120+8A>G	p.?	Unknown	Stomach
COSM1328269	c.2539G>C	p.V847L	Substitution - Missense	Ovary
COSM214010	c.361C>T	p.R121W	Substitution - Missense	Breast
COSM3850366	c.3130C>T	p.Q1044*	Substitution - Nonsense	Kidney
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Liver
COSM1619517	c.2893A>G	p.N965D	Substitution - Missense	Liver
COSM149915	c.3684G>A	p.V1228V	Substitution - coding silent	Large_intestine
COSM1753985	c.1447G>A	p.E483K	Substitution - Missense	Urinary_tract
COSM1696218	c.3679_3680CC>TT	p.P1227L	Substitution - Missense	Skin
COSM3826829	c.2713G>A	p.E905K	Substitution - Missense	Breast
COSM3608881	c.1988C>T	p.P663L	Substitution - Missense	Skin
COSM5672288	c.1093A>T	p.N365Y	Substitution - Missense	Soft_tissue
COSM1486317	c.779C>A	p.A260D	Substitution - Missense	Breast
COSM4666126	c.1605G>A	p.E535E	Substitution - coding silent	Large_intestine
COSM3236996	c.918A>G	p.Q306Q	Substitution - coding silent	Skin
COSM5425863	c.3381A>G	p.P1127P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM448644	c.3437+1G>A	p.?	Unknown	Breast
COSM3850369	c.2252C>A	p.P751H	Substitution - Missense	Stomach
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM3608874	c.3501A>G	p.Q1167Q	Substitution - coding silent	Skin
COSM1158531	c.2035C>G	p.Q679E	Substitution - Missense	Pancreas
COSM1061244	c.1177G>T	p.E393*	Substitution - Nonsense	Endometrium
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM3428936	c.3022G>A	p.V1008I	Substitution - Missense	Large_intestine
COSM1619516	c.2990C>A	p.T997N	Substitution - Missense	Liver
COSM1433320	c.2216A>G	p.D739G	Substitution - Missense	Large_intestine
COSM4835429	c.96G>T	p.M32I	Substitution - Missense	Cervix
COSM1061233	c.3078A>G	p.S1026S	Substitution - coding silent	Endometrium
COSM1061241	c.2068A>G	p.S690G	Substitution - Missense	Endometrium
COSM204731	c.2962G>A	p.E988K	Substitution - Missense	Endometrium
COSM1158531	c.2035C>G	p.Q679E	Substitution - Missense	Pancreas
COSM5569003	c.2900C>T	p.S967L	Substitution - Missense	Prostate
COSM5749378	c.2840T>C	p.L947P	Substitution - Missense	Genital_tract
COSM1061242	c.1873-1G>T	p.?	Unknown	Endometrium
COSM1061245	c.942G>A	p.A314A	Substitution - coding silent	Endometrium
COSM392079	c.3206_3207insA	p.C1069fs*1	Insertion - Frameshift	Lung
COSM274164	c.2896G>A	p.E966K	Substitution - Missense	Large_intestine
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Skin
COSM1642601	c.533_534insC	p.R179fs*19	Insertion - Frameshift	Stomach
COSM149915	c.3684G>A	p.V1228V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM735574	c.498A>G	p.A166A	Substitution - coding silent	Lung
COSM77351	c.1090A>T	p.I364F	Substitution - Missense	Ovary
COSM1130932	c.3201C>T	p.G1067G	Substitution - coding silent	Prostate
COSM4795262	c.1480G>A	p.G494R	Substitution - Missense	Liver
COSM1433322	c.1592C>G	p.A531G	Substitution - Missense	Large_intestine
COSM3674285	c.2498G>T	p.R833I	Substitution - Missense	Prostate
COSM3850371	c.2037G>C	p.Q679H	Substitution - Missense	Stomach
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Stomach
COSM1642605	c.116+7T>C	p.?	Unknown	Stomach
COSM3784575	c.2978T>A	p.L993H	Substitution - Missense	Pancreas
COSM6011941	c.2946G>A	p.R982R	Substitution - coding silent	Skin
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM149915	c.3684G>A	p.V1228V	Substitution - coding silent	Stomach
COSM1061235	c.2904T>C	p.S968S	Substitution - coding silent	Endometrium
COSM4003294	c.1587T>C	p.V529V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4474979	c.1737C>T	p.S579S	Substitution - coding silent	Skin
COSM1718169	c.963T>G	p.A321A	Substitution - coding silent	Skin
COSM1158531	c.2035C>G	p.Q679E	Substitution - Missense	Pancreas
COSM4135442	c.809T>G	p.L270R	Substitution - Missense	Pancreas
COSM3608873	c.3559C>T	p.H1187Y	Substitution - Missense	Skin
COSM1642603	c.440+1G>A	p.?	Unknown	Stomach
COSM3975181	c.1198A>G	p.M400V	Substitution - Missense	Central_nervous_system
COSM1733218	c.531_532insCC	p.R178fs*7	Insertion - Frameshift	Pancreas
COSM1061234	c.2995G>A	p.E999K	Substitution - Missense	Endometrium
COSM1619516	c.2990C>A	p.T997N	Substitution - Missense	Liver
COSM3918693	c.2249+2T>G	p.?	Unknown	Skin
COSM4761798	c.245G>C	p.R82P	Substitution - Missense	Stomach
COSM735575	c.1234G>C	p.D412H	Substitution - Missense	Lung
COSM4512857	c.700C>T	p.L234L	Substitution - coding silent	Skin
COSM5778688	c.1223G>A	p.G408D	Substitution - Missense	Breast
COSM3608877	c.3193C>T	p.P1065S	Substitution - Missense	Skin
COSM1671891	c.3194C>T	p.P1065L	Substitution - Missense	Large_intestine
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Thyroid
COSM589516	c.3488G>A	p.R1163H	Substitution - Missense	Large_intestine
COSM4666123	c.3597A>T	p.E1199D	Substitution - Missense	Large_intestine
COSM204731	c.2962G>A	p.E988K	Substitution - Missense	Pancreas
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Pancreas
COSM4625408	c.717C>T	p.V239V	Substitution - coding silent	Large_intestine
COSM5830029	c.2250-3delT	p.?	Unknown	Large_intestine
COSM256416	c.2758G>T	p.E920*	Substitution - Nonsense	Large_intestine
COSM4666125	c.2751G>A	p.P917P	Substitution - coding silent	Large_intestine
COSM4171368	c.268G>A	p.E90K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM4890940	c.69G>C	p.E23D	Substitution - Missense	Upper_aerodigestive_tract
COSM308640	c.532_533insC	p.R178fs*20	Insertion - Frameshift	Lung
COSM1433315	c.3120+2T>C	p.?	Unknown	Large_intestine
COSM5455343	c.160C>T	p.R54C	Substitution - Missense	Large_intestine
COSM2157779	c.673_674insT	p.G225fs*67	Insertion - Frameshift	Central_nervous_system
COSM234447	c.1362C>T	p.S454S	Substitution - coding silent	Skin
COSM1433318	c.2442G>A	p.T814T	Substitution - coding silent	Large_intestine
COSM3365844	c.2742A>G	p.E914E	Substitution - coding silent	Kidney
COSM448643	c.3482G>A	p.R1161Q	Substitution - Missense	Bone
COSM3608878	c.3017C>T	p.P1006L	Substitution - Missense	Skin
COSM1753989	c.671C>T	p.S224F	Substitution - Missense	Upper_aerodigestive_tract
COSM1433317	c.2916C>T	p.C972C	Substitution - coding silent	Large_intestine
COSM4666128	c.1567G>A	p.E523K	Substitution - Missense	Large_intestine
COSM4539978	c.2548G>A	p.G850S	Substitution - Missense	Skin
COSM3736847	c.673G>T	p.G225C	Substitution - Missense	Upper_aerodigestive_tract
COSM1061230	c.3313C>A	p.H1105N	Substitution - Missense	Endometrium
COSM3236950	c.2328T>C	p.I776I	Substitution - coding silent	Upper_aerodigestive_tract
COSM1433329	c.532delC	p.R178fs*6	Deletion - Frameshift	Large_intestine
COSM3409756	c.892C>T	p.P298S	Substitution - Missense	Central_nervous_system
COSM1433314	c.3202G>A	p.E1068K	Substitution - Missense	Large_intestine
COSM3409755	c.3124G>A	p.E1042K	Substitution - Missense	Central_nervous_system
COSM5886380	c.2719C>T	p.P907S	Substitution - Missense	Skin
COSM149915	c.3684G>A	p.V1228V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5996162	c.3701T>C	p.V1234A	Substitution - Missense	Prostate
COSM448645	c.457G>A	p.E153K	Substitution - Missense	Breast
COSM149916	c.3120+8A>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5794040	c.2621C>T	p.P874L	Substitution - Missense	Breast
COSM5425863	c.3381A>G	p.P1127P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4585418	c.3033G>A	p.K1011K	Substitution - coding silent	Bone
COSM5912187	c.164C>T	p.P55L	Substitution - Missense	Skin
COSM5486446	c.2496G>T	p.G832G	Substitution - coding silent	Large_intestine
COSM5402172	c.2062C>T	p.P688S	Substitution - Missense	Skin
COSM4538824	c.2388G>A	p.M796I	Substitution - Missense	Skin
COSM1486316	c.3302C>G	p.P1101R	Substitution - Missense	Breast
COSM4168041	c.673_679delGGCCACC	p.G225fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4666130	c.532C>T	p.R178W	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for BRD8.

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9H0E9	383	S	Phosphoserine	-	No	None detected
Q9H0E9	387	S	Phosphoserine	-	No	None detected
Q9H0E9	481	K	N6-acetyllysine	-	No	None detected
Q9H0E9	579	S	Phosphoserine	-	No	None detected
Q9H0E9	621	S	Phosphoserine	-	No	None detected
Q9H0E9	637	S	Phosphoserine	-	No	None detected
Q9H0E9	641	S	Phosphoserine	-	No	None detected

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.345	5.366	0.101	0.49	NS
BRCA	Breast invasive carcinoma	112	1100	5.826	5.903	0.068	0.194	NS
CESC	Cervical and endocervical cancers	3	306	6.067	5.781	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.288	5.52	0.266	7.72e-05	NS
ESCA	Esophageal carcinoma	11	185	5.213	5.234	0.047	0.827	NS
GBM	Glioblastoma multiforme	5	166	6.193	6.123	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.955	4.839	-0.172	0.0609	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.512	5.639	0.119	0.0454	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.488	5.549	0.063	0.472	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.093	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.392	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.06	4.66	0.635	3.24e-14	Over
LUAD	Lung adenocarcinoma	59	517	5.329	5.539	0.324	1.66e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	5.277	5.15	-0.049	0.546	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.949	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.361	5.342	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.354	5.957	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.75	5.772	0.069	0.185	NS
READ	Rectum adenocarcinoma	10	167	5.386	5.502	0.209	0.184	NS
SARC	Sarcoma	2	263	5.339	5.642	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.387	5.611	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.166	5.289	0.192	0.031	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.29	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.872	5.821	-0.016	0.742	NS
THYM	Thymoma	2	120	6.32	6.194	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.897	5.778	-0.117	0.211	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.3
Autonomic ganglia	CHP212	7.8
Autonomic ganglia	IMR32	7.9
Autonomic ganglia	KELLY	7.8
Autonomic ganglia	KPNRTBM1	8.3
Autonomic ganglia	KPNSI9S	7.3
Autonomic ganglia	KPNYN	8.2
Autonomic ganglia	MHHNB11	7.8
Autonomic ganglia	NB1	7.4
Autonomic ganglia	NH6	8.1
Autonomic ganglia	SHSY5Y	7.9
Autonomic ganglia	SIMA	7.8
Autonomic ganglia	SKNAS	7.7
Autonomic ganglia	SKNBE2	8
Autonomic ganglia	SKNDZ	8.5
Autonomic ganglia	SKNFI	8.2
Autonomic ganglia	SKNSH	7.6
Biliary tract	HUCCT1	8
Biliary tract	HUH28	8.6
Biliary tract	SNU1079	7.7
Biliary tract	SNU1196	7.6
Biliary tract	SNU245	7.7
Biliary tract	SNU308	7.8
Biliary tract	SNU478	7.7
Bone	143B	7.7
Bone	A673	7.9
Bone	CADOES1	7.8
Bone	CAL78	7.9
Bone	G292CLONEA141B1	7.6
Bone	HOS	7.7
Bone	HS706T	8.1
Bone	HS737T	7.4
Bone	HS819T	7.3
Bone	HS821T	7.1
Bone	HS822T	7.2
Bone	HS863T	6.9
Bone	HS870T	7.8
Bone	HS888T	7.7
Bone	MG63	8.4
Bone	MHHES1	8.3
Bone	OUMS27	7.7
Bone	RDES	7.6
Bone	SJSA1	8.3
Bone	SKES1	7.8
Bone	SKNMC	8.1
Bone	SW1353	7.7
Bone	T173	7.6
Bone	TC71	7.6
Bone	U2OS	7.9
Breast	AU565	7.3
Breast	BT20	7.9
Breast	BT474	8
Breast	BT483	7.5
Breast	BT549	7.9
Breast	CAL120	7.7
Breast	CAL148	7.9
Breast	CAL51	8.3
Breast	CAL851	7.5
Breast	CAMA1	8.7
Breast	DU4475	7.5
Breast	EFM192A	8.5
Breast	EFM19	7.5
Breast	EVSAT	7.6
Breast	HCC1143	8
Breast	HCC1187	7.6
Breast	HCC1395	7.6
Breast	HCC1419	7.5
Breast	HCC1428	7.5
Breast	HCC1500	7.8
Breast	HCC1569	7.8
Breast	HCC1599	8
Breast	HCC1806	8.1
Breast	HCC1937	8.4
Breast	HCC1954	7.4
Breast	HCC202	7.5
Breast	HCC2157	8.1
Breast	HCC2218	7.7
Breast	HCC38	7.8
Breast	HCC70	7.2
Breast	HDQP1	7.8
Breast	HMC18	8.3
Breast	HS274T	7.8
Breast	HS281T	7.2
Breast	HS343T	7.6
Breast	HS578T	7.5
Breast	HS606T	7.6
Breast	HS739T	7.5
Breast	HS742T	7
Breast	JIMT1	7.3
Breast	KPL1	8
Breast	MCF7	7.7
Breast	MDAMB134VI	8.9
Breast	MDAMB157	8.2
Breast	MDAMB175VII	7.1
Breast	MDAMB231	7.9
Breast	MDAMB361	7.7
Breast	MDAMB415	8.4
Breast	MDAMB436	7.3
Breast	MDAMB453	8.2
Breast	MDAMB468	7.7
Breast	SKBR3	7.3
Breast	T47D	7.9
Breast	UACC812	8.2
Breast	UACC893	7.1
Breast	YMB1	7.2
Breast	ZR751	7.6
Breast	ZR7530	7.6
Central nervous system	1321N1	8
Central nervous system	42MGBA	8
Central nervous system	8MGBA	7.5
Central nervous system	A172	7.7
Central nervous system	AM38	7.5
Central nervous system	BECKER	7.9
Central nervous system	CAS1	8
Central nervous system	CCFSTTG1	7.9
Central nervous system	D283MED	8.8
Central nervous system	D341MED	8.1
Central nervous system	DAOY	8.1
Central nervous system	DBTRG05MG	7.2
Central nervous system	DKMG	7.4
Central nervous system	GAMG	7.9
Central nervous system	GB1	7.5
Central nervous system	GI1	7.7
Central nervous system	GMS10	7.9
Central nervous system	GOS3	7.9
Central nervous system	H4	7.9
Central nervous system	HS683	8.1
Central nervous system	KALS1	7.9
Central nervous system	KG1C	8.4
Central nervous system	KNS42	7.7
Central nervous system	KNS60	8.1
Central nervous system	KNS81	7.9
Central nervous system	KS1	7.7
Central nervous system	LN18	8.3
Central nervous system	LN229	7.8
Central nervous system	M059K	7.8
Central nervous system	MOGGCCM	8
Central nervous system	MOGGUVW	7.6
Central nervous system	NMCG1	7.6
Central nervous system	ONS76	7.8
Central nervous system	SF126	7.8
Central nervous system	SF295	8.1
Central nervous system	SNB19	7.8
Central nervous system	SNU1105	7.5
Central nervous system	SNU201	7.8
Central nervous system	SNU466	7.5
Central nervous system	SNU489	7.5
Central nervous system	SNU626	7.8
Central nervous system	SNU738	7.8
Central nervous system	SW1088	8.3
Central nervous system	SW1783	7.7
Central nervous system	T98G	8.3
Central nervous system	TM31	7.2
Central nervous system	U118MG	7.4
Central nervous system	U138MG	7.4
Central nervous system	U251MG	7.7
Central nervous system	U87MG	7.3
Central nervous system	YH13	7.9
Central nervous system	YKG1	7.6
Endometrium	AN3CA	9
Endometrium	COLO684	7.5
Endometrium	EFE184	7.7
Endometrium	EN	7.9
Endometrium	ESS1	7.9
Endometrium	HEC108	8.8
Endometrium	HEC151	7.2
Endometrium	HEC1A	8.1
Endometrium	HEC1B	8
Endometrium	HEC251	7.7
Endometrium	HEC265	7.5
Endometrium	HEC50B	7.8
Endometrium	HEC59	7.7
Endometrium	HEC6	7.7
Endometrium	ISHIKAWAHERAKLIO02ER	7.6
Endometrium	JHUEM1	7.5
Endometrium	JHUEM2	7.7
Endometrium	JHUEM3	7.7
Endometrium	KLE	7.9
Endometrium	MFE280	9.1
Endometrium	MFE296	7.5
Endometrium	MFE319	7.7
Endometrium	RL952	7.9
Endometrium	SNGM	7.3
Endometrium	SNU1077	7.8
Endometrium	SNU685	7.1
Endometrium	TEN	8.3
Haematopoietic and lymphoid	697	8
Haematopoietic and lymphoid	A3KAW	7.9
Haematopoietic and lymphoid	A4FUK	8.1
Haematopoietic and lymphoid	ALLSIL	8
Haematopoietic and lymphoid	AML193	7.7
Haematopoietic and lymphoid	AMO1	8
Haematopoietic and lymphoid	BCP1	8
Haematopoietic and lymphoid	BDCM	7.6
Haematopoietic and lymphoid	BL41	7.5
Haematopoietic and lymphoid	BL70	8.2
Haematopoietic and lymphoid	BV173	8.2
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	8
Haematopoietic and lymphoid	CMK115	7.7
Haematopoietic and lymphoid	CMK86	7.5
Haematopoietic and lymphoid	CMK	7.7
Haematopoietic and lymphoid	CMLT1	7.8
Haematopoietic and lymphoid	COLO775	7.4
Haematopoietic and lymphoid	DAUDI	7.8
Haematopoietic and lymphoid	DB	7.6
Haematopoietic and lymphoid	DEL	8.5
Haematopoietic and lymphoid	DND41	8.3
Haematopoietic and lymphoid	DOHH2	7.7
Haematopoietic and lymphoid	EB1	7.7
Haematopoietic and lymphoid	EB2	7.8
Haematopoietic and lymphoid	EHEB	7.2
Haematopoietic and lymphoid	EJM	7.8
Haematopoietic and lymphoid	EM2	7.8
Haematopoietic and lymphoid	EOL1	8.1
Haematopoietic and lymphoid	F36P	8.1
Haematopoietic and lymphoid	GA10	7.8
Haematopoietic and lymphoid	GDM1	8.1
Haematopoietic and lymphoid	GRANTA519	7.9
Haematopoietic and lymphoid	HDLM2	7.8
Haematopoietic and lymphoid	HDMYZ	7.9
Haematopoietic and lymphoid	HEL9217	7.7
Haematopoietic and lymphoid	HEL	7.4
Haematopoietic and lymphoid	HH	7.7
Haematopoietic and lymphoid	HL60	7.6
Haematopoietic and lymphoid	HPBALL	7.8
Haematopoietic and lymphoid	HS604T	7.6
Haematopoietic and lymphoid	HS611T	7.9
Haematopoietic and lymphoid	HS616T	7.5
Haematopoietic and lymphoid	HS751T	7.7
Haematopoietic and lymphoid	HT	8.3
Haematopoietic and lymphoid	HTK	7.5
Haematopoietic and lymphoid	HUNS1	7.8
Haematopoietic and lymphoid	HUT102	7.4
Haematopoietic and lymphoid	HUT78	8.1
Haematopoietic and lymphoid	JEKO1	8.1
Haematopoietic and lymphoid	JK1	8.2
Haematopoietic and lymphoid	JM1	8.3
Haematopoietic and lymphoid	JURKAT	7.9
Haematopoietic and lymphoid	JURLMK1	8.1
Haematopoietic and lymphoid	JVM2	7.1
Haematopoietic and lymphoid	JVM3	7.4
Haematopoietic and lymphoid	K562	7.9
Haematopoietic and lymphoid	KARPAS299	7.9
Haematopoietic and lymphoid	KARPAS422	7.9
Haematopoietic and lymphoid	KARPAS620	7.6
Haematopoietic and lymphoid	KASUMI1	7.9
Haematopoietic and lymphoid	KASUMI2	8.1
Haematopoietic and lymphoid	KASUMI6	8
Haematopoietic and lymphoid	KCL22	7.5
Haematopoietic and lymphoid	KE37	8.1
Haematopoietic and lymphoid	KE97	7.6
Haematopoietic and lymphoid	KG1	7.3
Haematopoietic and lymphoid	KHM1B	7.5
Haematopoietic and lymphoid	KIJK	8.2
Haematopoietic and lymphoid	KMH2	7.6
Haematopoietic and lymphoid	KMM1	8.3
Haematopoietic and lymphoid	KMS11	8
Haematopoietic and lymphoid	KMS12BM	7
Haematopoietic and lymphoid	KMS18	7.7
Haematopoietic and lymphoid	KMS20	8.2
Haematopoietic and lymphoid	KMS21BM	7.4
Haematopoietic and lymphoid	KMS26	7.7
Haematopoietic and lymphoid	KMS27	7.7
Haematopoietic and lymphoid	KMS28BM	7.9
Haematopoietic and lymphoid	KMS34	8.1
Haematopoietic and lymphoid	KO52	8.2
Haematopoietic and lymphoid	KOPN8	7.7
Haematopoietic and lymphoid	KU812	7.9
Haematopoietic and lymphoid	KYO1	8.3
Haematopoietic and lymphoid	L1236	8.4
Haematopoietic and lymphoid	L363	8
Haematopoietic and lymphoid	L428	7.7
Haematopoietic and lymphoid	L540	7.6
Haematopoietic and lymphoid	LAMA84	8.7
Haematopoietic and lymphoid	LOUCY	8
Haematopoietic and lymphoid	LP1	7
Haematopoietic and lymphoid	M07E	7.9
Haematopoietic and lymphoid	MC116	7.8
Haematopoietic and lymphoid	ME1	7.4
Haematopoietic and lymphoid	MEC1	7.4
Haematopoietic and lymphoid	MEC2	7.3
Haematopoietic and lymphoid	MEG01	8.5
Haematopoietic and lymphoid	MHHCALL2	8.2
Haematopoietic and lymphoid	MHHCALL3	8.2
Haematopoietic and lymphoid	MHHCALL4	8.1
Haematopoietic and lymphoid	MINO	7.6
Haematopoietic and lymphoid	MJ	7.9
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	7.8
Haematopoietic and lymphoid	MOLM16	7.5
Haematopoietic and lymphoid	MOLM6	7.5
Haematopoietic and lymphoid	MOLP2	7.1
Haematopoietic and lymphoid	MOLP8	7.7
Haematopoietic and lymphoid	MOLT13	8.1
Haematopoietic and lymphoid	MOLT16	7.5
Haematopoietic and lymphoid	MOLT4	8
Haematopoietic and lymphoid	MONOMAC1	7.6
Haematopoietic and lymphoid	MONOMAC6	7.8
Haematopoietic and lymphoid	MOTN1	8
Haematopoietic and lymphoid	MUTZ5	8.2
Haematopoietic and lymphoid	MV411	8
Haematopoietic and lymphoid	NALM19	8.8
Haematopoietic and lymphoid	NALM1	8.1
Haematopoietic and lymphoid	NALM6	8.2
Haematopoietic and lymphoid	NAMALWA	7.5
Haematopoietic and lymphoid	NB4	7.8
Haematopoietic and lymphoid	NCIH929	8.1
Haematopoietic and lymphoid	NCO2	7.7
Haematopoietic and lymphoid	NOMO1	7.4
Haematopoietic and lymphoid	NUDHL1	7.8
Haematopoietic and lymphoid	NUDUL1	7.9
Haematopoietic and lymphoid	OCIAML2	7.9
Haematopoietic and lymphoid	OCIAML3	7.5
Haematopoietic and lymphoid	OCIAML5	7.5
Haematopoietic and lymphoid	OCILY10	7.6
Haematopoietic and lymphoid	OCILY19	8.2
Haematopoietic and lymphoid	OCILY3	7.6
Haematopoietic and lymphoid	OCIM1	8.7
Haematopoietic and lymphoid	OPM2	6.6
Haematopoietic and lymphoid	P12ICHIKAWA	8
Haematopoietic and lymphoid	P31FUJ	7.2
Haematopoietic and lymphoid	P3HR1	8
Haematopoietic and lymphoid	PCM6	7.3
Haematopoietic and lymphoid	PEER	8.1
Haematopoietic and lymphoid	PF382	7.9
Haematopoietic and lymphoid	PFEIFFER	8.3
Haematopoietic and lymphoid	PL21	7.5
Haematopoietic and lymphoid	RAJI	8
Haematopoietic and lymphoid	RCHACV	7.7
Haematopoietic and lymphoid	REC1	7.4
Haematopoietic and lymphoid	REH	8.4
Haematopoietic and lymphoid	RI1	8
Haematopoietic and lymphoid	RL	7.5
Haematopoietic and lymphoid	RPMI8226	7.9
Haematopoietic and lymphoid	RPMI8402	8.1
Haematopoietic and lymphoid	RS411	8.3
Haematopoietic and lymphoid	SEM	8.1
Haematopoietic and lymphoid	SET2	7.2
Haematopoietic and lymphoid	SIGM5	7.7
Haematopoietic and lymphoid	SKM1	8
Haematopoietic and lymphoid	SKMM2	8
Haematopoietic and lymphoid	SR786	7.6
Haematopoietic and lymphoid	ST486	7.8
Haematopoietic and lymphoid	SUDHL10	7.1
Haematopoietic and lymphoid	SUDHL1	8.1
Haematopoietic and lymphoid	SUDHL4	7.7
Haematopoietic and lymphoid	SUDHL5	7.3
Haematopoietic and lymphoid	SUDHL6	7.5
Haematopoietic and lymphoid	SUDHL8	8.5
Haematopoietic and lymphoid	SUPB15	8.1
Haematopoietic and lymphoid	SUPHD1	7.6
Haematopoietic and lymphoid	SUPM2	8.2
Haematopoietic and lymphoid	SUPT11	8.1
Haematopoietic and lymphoid	SUPT1	8.1
Haematopoietic and lymphoid	TALL1	8.1
Haematopoietic and lymphoid	TF1	7.8
Haematopoietic and lymphoid	THP1	7.8
Haematopoietic and lymphoid	TO175T	8
Haematopoietic and lymphoid	TOLEDO	8.1
Haematopoietic and lymphoid	U266B1	7.5
Haematopoietic and lymphoid	U937	7.3
Haematopoietic and lymphoid	UT7	7.9
Haematopoietic and lymphoid	WSUDLCL2	7.7
Kidney	769P	7.4
Kidney	786O	7.4
Kidney	A498	7.2
Kidney	A704	7.9
Kidney	ACHN	7.5
Kidney	BFTC909	7.8
Kidney	CAKI1	7.6
Kidney	CAKI2	7.3
Kidney	CAL54	7.3
Kidney	KMRC1	7
Kidney	KMRC20	7.8
Kidney	KMRC2	7.5
Kidney	KMRC3	7.7
Kidney	OSRC2	7.1
Kidney	RCC10RGB	7.8
Kidney	SNU1272	7.9
Kidney	SNU349	7.5
Kidney	TUHR10TKB	7.5
Kidney	TUHR14TKB	7.7
Kidney	TUHR4TKB	7.6
Kidney	VMRCRCW	8.3
Kidney	VMRCRCZ	8
Large intestine	C2BBE1	7.7
Large intestine	CCK81	7.8
Large intestine	CL11	7.6
Large intestine	CL14	7.3
Large intestine	CL34	7.7
Large intestine	CL40	7.2
Large intestine	COLO205	7.9
Large intestine	COLO320	7.5
Large intestine	COLO678	7.6
Large intestine	CW2	7.3
Large intestine	DLD1	7.5
Large intestine	GP2D	7.8
Large intestine	HCC56	8.2
Large intestine	HCT116	7.4
Large intestine	HCT15	7.6
Large intestine	HS675T	7.5
Large intestine	HS698T	7.6
Large intestine	HT115	7.7
Large intestine	HT29	7.8
Large intestine	HT55	7.6
Large intestine	KM12	8.5
Large intestine	LOVO	8.3
Large intestine	LS1034	7.9
Large intestine	LS123	7.8
Large intestine	LS180	7.9
Large intestine	LS411N	8.3
Large intestine	LS513	7.7
Large intestine	MDST8	7.2
Large intestine	NCIH508	7.8
Large intestine	NCIH716	7.1
Large intestine	NCIH747	7.8
Large intestine	OUMS23	8.2
Large intestine	RCM1	8.1
Large intestine	RKO	7.9
Large intestine	SKCO1	7.5
Large intestine	SNU1040	7.8
Large intestine	SNU1197	7.8
Large intestine	SNU175	7.6
Large intestine	SNU283	7.6
Large intestine	SNU407	7.8
Large intestine	SNU503	7.8
Large intestine	SNU61	7.5
Large intestine	SNU81	7.8
Large intestine	SNUC1	7.1
Large intestine	SNUC2A	8.6
Large intestine	SNUC4	7.9
Large intestine	SNUC5	8.5
Large intestine	SW1116	8.7
Large intestine	SW1417	8.4
Large intestine	SW1463	7.8
Large intestine	SW403	7.7
Large intestine	SW480	7.7
Large intestine	SW48	7.5
Large intestine	SW620	7.9
Large intestine	SW837	8.3
Large intestine	SW948	7.6
Large intestine	T84	7.6
Liver	ALEXANDERCELLS	7.7
Liver	C3A	7.5
Liver	HEP3B217	7.1
Liver	HEPG2	7.4
Liver	HLE	8.1
Liver	HLF	8
Liver	HUH1	7.7
Liver	HUH6	7.9
Liver	HUH7	7.7
Liver	JHH1	8
Liver	JHH2	7.1
Liver	JHH4	8
Liver	JHH5	7.9
Liver	JHH6	8
Liver	JHH7	7.6
Liver	LI7	8.1
Liver	PLCPRF5	7.5
Liver	SKHEP1	7.5
Liver	SNU182	7.6
Liver	SNU387	7.8
Liver	SNU398	8.1
Liver	SNU423	7.9
Liver	SNU449	7.1
Liver	SNU475	7.4
Liver	SNU761	7.1
Liver	SNU878	7.7
Liver	SNU886	7.7
Lung	A549	7.4
Lung	ABC1	7.3
Lung	BEN	7.3
Lung	CAL12T	7.7
Lung	CALU1	7.8
Lung	CALU3	7.6
Lung	CALU6	8.1
Lung	CHAGOK1	8.3
Lung	COLO668	7.6
Lung	COLO699	8
Lung	CORL105	7.7
Lung	CORL23	7.4
Lung	CORL24	8.3
Lung	CORL279	6.9
Lung	CORL311	7.2
Lung	CORL47	7.7
Lung	CORL51	7.2
Lung	CORL88	7.8
Lung	CORL95	7.7
Lung	CPCN	8.1
Lung	DMS114	8.3
Lung	DMS153	7.5
Lung	DMS273	7.6
Lung	DMS454	7.5
Lung	DMS53	8
Lung	DMS79	7.5
Lung	DV90	7.9
Lung	EBC1	7.8
Lung	EPLC272H	7.9
Lung	HARA	7.9
Lung	HCC1171	7.7
Lung	HCC1195	7.7
Lung	HCC15	8.3
Lung	HCC2279	8.3
Lung	HCC2935	7.3
Lung	HCC33	8.1
Lung	HCC366	7.8
Lung	HCC4006	7.1
Lung	HCC44	7.1
Lung	HCC78	8.5
Lung	HCC827	7.7
Lung	HCC95	7.8
Lung	HLC1	8
Lung	HLFA	7.7
Lung	HS229T	7.8
Lung	HS618T	7.6
Lung	IALM	8.6
Lung	KNS62	6.8
Lung	LC1F	7.5
Lung	LC1SQSF	7.3
Lung	LCLC103H	7.6
Lung	LCLC97TM1	7.9
Lung	LK2	8.1
Lung	LOUNH91	7.9
Lung	LU65	8.4
Lung	LU99	8.4
Lung	LUDLU1	7.5
Lung	LXF289	7.9
Lung	MORCPR	7.7
Lung	NCIH1048	8.2
Lung	NCIH1092	7.8
Lung	NCIH1105	7.7
Lung	NCIH1155	7.7
Lung	NCIH1184	8.1
Lung	NCIH1299	8.2
Lung	NCIH1339	7.5
Lung	NCIH1341	8.1
Lung	NCIH1355	7.7
Lung	NCIH1373	8.7
Lung	NCIH1385	7.2
Lung	NCIH1395	7.2
Lung	NCIH1435	7
Lung	NCIH1436	8
Lung	NCIH1437	7.7
Lung	NCIH146	7.8
Lung	NCIH1563	7.3
Lung	NCIH1568	7.8
Lung	NCIH1573	8.3
Lung	NCIH1581	7.4
Lung	NCIH1618	8.1
Lung	NCIH1623	7.9
Lung	NCIH1648	7.8
Lung	NCIH1650	7.9
Lung	NCIH1651	7.9
Lung	NCIH1666	7.6
Lung	NCIH1693	8.1
Lung	NCIH1694	7.9
Lung	NCIH1703	7.8
Lung	NCIH1734	7.8
Lung	NCIH1755	7.9
Lung	NCIH1781	7.6
Lung	NCIH1792	7.3
Lung	NCIH1793	7.9
Lung	NCIH1836	8
Lung	NCIH1838	7.4
Lung	NCIH1869	8
Lung	NCIH1876	8.2
Lung	NCIH1915	8
Lung	NCIH1930	8.1
Lung	NCIH1944	7.5
Lung	NCIH1963	7.5
Lung	NCIH196	7.6
Lung	NCIH1975	7.8
Lung	NCIH2009	7.3
Lung	NCIH2023	7.5
Lung	NCIH2029	8.7
Lung	NCIH2030	7.8
Lung	NCIH2066	7.9
Lung	NCIH2081	7.5
Lung	NCIH2085	8.1
Lung	NCIH2087	8.1
Lung	NCIH209	8.5
Lung	NCIH2106	8
Lung	NCIH2110	7.5
Lung	NCIH211	7.8
Lung	NCIH2122	7.6
Lung	NCIH2126	7.4
Lung	NCIH2141	8.1
Lung	NCIH2170	7.1
Lung	NCIH2171	7.4
Lung	NCIH2172	7.6
Lung	NCIH2196	8
Lung	NCIH2227	7.9
Lung	NCIH2228	8.1
Lung	NCIH226	7.9
Lung	NCIH2286	7.9
Lung	NCIH2291	7.2
Lung	NCIH2342	8.5
Lung	NCIH2347	7.6
Lung	NCIH23	8.2
Lung	NCIH2405	7.9
Lung	NCIH2444	7.2
Lung	NCIH292	7.4
Lung	NCIH322	7.5
Lung	NCIH3255	7.2
Lung	NCIH358	7.6
Lung	NCIH441	8.1
Lung	NCIH446	7.5
Lung	NCIH460	7.6
Lung	NCIH510	7.9
Lung	NCIH520	8
Lung	NCIH522	7.6
Lung	NCIH524	8.1
Lung	NCIH526	7.8
Lung	NCIH596	7.6
Lung	NCIH647	7.7
Lung	NCIH650	8.2
Lung	NCIH661	7.7
Lung	NCIH69	7.9
Lung	NCIH727	7.9
Lung	NCIH810	7.7
Lung	NCIH82	7.9
Lung	NCIH838	8
Lung	NCIH841	8.3
Lung	NCIH854	7.3
Lung	NCIH889	7.5
Lung	PC14	7.3
Lung	RERFLCAD1	8.2
Lung	RERFLCAD2	8
Lung	RERFLCAI	7.8
Lung	RERFLCKJ	7.9
Lung	RERFLCMS	8
Lung	RERFLCSQ1	7.6
Lung	SBC5	7.9
Lung	SCLC21H	8.3
Lung	SHP77	7.7
Lung	SKLU1	8
Lung	SKMES1	7.7
Lung	SQ1	7.5
Lung	SW1271	8.5
Lung	SW1573	8.7
Lung	SW900	7.6
Lung	VMRCLCD	7.6
Lung	VMRCLCP	7.9
Oesophagus	COLO680N	7.6
Oesophagus	ECGI10	7.1
Oesophagus	KYSE140	8.1
Oesophagus	KYSE150	7.1
Oesophagus	KYSE180	7.5
Oesophagus	KYSE270	7.8
Oesophagus	KYSE30	8.7
Oesophagus	KYSE410	8
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	8.1
Oesophagus	KYSE520	8.1
Oesophagus	KYSE70	7.5
Oesophagus	OE19	7
Oesophagus	OE33	7.5
Oesophagus	TE10	7.8
Oesophagus	TE11	7.6
Oesophagus	TE14	8.3
Oesophagus	TE15	7.7
Oesophagus	TE1	7
Oesophagus	TE4	7.4
Oesophagus	TE5	7.6
Oesophagus	TE6	8
Oesophagus	TE8	8.2
Oesophagus	TE9	7.8
Oesophagus	TT	8.2
Ovary	59M	7.9
Ovary	A2780	7.6
Ovary	CAOV3	7.8
Ovary	CAOV4	8.4
Ovary	COLO704	7.7
Ovary	COV318	7.7
Ovary	COV362	7.8
Ovary	COV434	7.2
Ovary	COV504	8.3
Ovary	COV644	8
Ovary	EFO21	8
Ovary	EFO27	7.8
Ovary	ES2	7.5
Ovary	FUOV1	8.2
Ovary	HEYA8	7.8
Ovary	HS571T	7.5
Ovary	IGROV1	7.4
Ovary	JHOC5	7.5
Ovary	JHOM1	7.1
Ovary	JHOM2B	7.8
Ovary	JHOS2	8.2
Ovary	JHOS4	7.5
Ovary	KURAMOCHI	8.3
Ovary	MCAS	7.6
Ovary	NIHOVCAR3	7.7
Ovary	OAW28	7.6
Ovary	OAW42	8
Ovary	OC314	7.8
Ovary	OC316	8
Ovary	ONCODG1	7.4
Ovary	OV56	8
Ovary	OV7	7.5
Ovary	OV90	7.6
Ovary	OVCAR4	7.4
Ovary	OVCAR8	7.9
Ovary	OVISE	7.5
Ovary	OVK18	8.1
Ovary	OVKATE	7.7
Ovary	OVMANA	8
Ovary	OVSAHO	8.3
Ovary	OVTOKO	7.6
Ovary	RMGI	7.4
Ovary	RMUGS	7.8
Ovary	SKOV3	7.7
Ovary	SNU119	7.5
Ovary	SNU840	8.1
Ovary	SNU8	7.9
Ovary	TOV112D	7.8
Ovary	TOV21G	7.4
Ovary	TYKNU	7.4
Pancreas	ASPC1	8
Pancreas	BXPC3	7.3
Pancreas	CAPAN1	7.6
Pancreas	CAPAN2	8.2
Pancreas	CFPAC1	8.2
Pancreas	DANG	7.2
Pancreas	HPAC	9
Pancreas	HPAFII	7.7
Pancreas	HS766T	8.1
Pancreas	HUPT3	7.8
Pancreas	HUPT4	7.9
Pancreas	KCIMOH1	8
Pancreas	KLM1	7.8
Pancreas	KP2	8
Pancreas	KP3	7.7
Pancreas	KP4	8.6
Pancreas	L33	8.1
Pancreas	MIAPACA2	8.6
Pancreas	PANC0203	8.3
Pancreas	PANC0213	7.3
Pancreas	PANC0327	7.9
Pancreas	PANC0403	7.3
Pancreas	PANC0504	7.6
Pancreas	PANC0813	7.2
Pancreas	PANC1005	8.1
Pancreas	PANC1	7.9
Pancreas	PATU8902	8.4
Pancreas	PATU8988S	7.9
Pancreas	PATU8988T	8.2
Pancreas	PK1	7.7
Pancreas	PK45H	7.5
Pancreas	PK59	7.7
Pancreas	PL45	8.3
Pancreas	PSN1	7.6
Pancreas	QGP1	8.1
Pancreas	SNU213	7.8
Pancreas	SNU324	7.8
Pancreas	SNU410	7.9
Pancreas	SU8686	7.4
Pancreas	SUIT2	7.6
Pancreas	SW1990	7.3
Pancreas	T3M4	7.8
Pancreas	TCCPAN2	7.7
Pancreas	YAPC	7.9
Pleura	ACCMESO1	7.9
Pleura	DM3	7
Pleura	ISTMES1	8.2
Pleura	ISTMES2	8
Pleura	JL1	7.7
Pleura	MPP89	8
Pleura	MSTO211H	8.1
Pleura	NCIH2052	7.7
Pleura	NCIH2452	8.2
Pleura	NCIH28	8.3
Prostate	22RV1	8.1
Prostate	DU145	7.9
Prostate	LNCAPCLONEFGC	7.6
Prostate	MDAPCA2B	7.7
Prostate	NCIH660	8.4
Prostate	PC3	7.6
Prostate	VCAP	9.3
Salivary gland	A253	7.8
Salivary gland	YD15	8
Skin	A101D	7.3
Skin	A2058	7.2
Skin	A375	8
Skin	C32	7.4
Skin	CHL1	7.5
Skin	CJM	7.9
Skin	COLO679	7
Skin	COLO741	7
Skin	COLO783	7.2
Skin	COLO792	7.4
Skin	COLO800	7.3
Skin	COLO818	7.2
Skin	COLO829	6.7
Skin	COLO849	7.1
Skin	G361	7.1
Skin	GRM	7.7
Skin	HMCB	7.7
Skin	HS294T	7.3
Skin	HS600T	7.7
Skin	HS688AT	7.4
Skin	HS695T	8
Skin	HS839T	7.7
Skin	HS852T	7.4
Skin	HS895T	7.1
Skin	HS934T	8
Skin	HS936T	7.4
Skin	HS939T	7.5
Skin	HS940T	7.4
Skin	HS944T	7.7
Skin	HT144	7.9
Skin	IGR1	7.9
Skin	IGR37	7.3
Skin	IGR39	7.9
Skin	IPC298	7.3
Skin	K029AX	7.7
Skin	LOXIMVI	8
Skin	MALME3M	6.8
Skin	MDAMB435S	7.5
Skin	MELHO	7.1
Skin	MELJUSO	7.4
Skin	MEWO	7.7
Skin	RPMI7951	7.5
Skin	RVH421	7.4
Skin	SH4	7.4
Skin	SKMEL1	7.5
Skin	SKMEL24	7.2
Skin	SKMEL28	7.6
Skin	SKMEL2	8.1
Skin	SKMEL30	8
Skin	SKMEL31	7.9
Skin	SKMEL3	7.4
Skin	SKMEL5	7.6
Skin	UACC257	7.2
Skin	UACC62	7.5
Skin	WM115	7.4
Skin	WM1799	7.3
Skin	WM2664	7.2
Skin	WM793	7.2
Skin	WM88	7.4
Skin	WM983B	7.9
Small intestine	HUTU80	8.1
Soft tissue	A204	7.8
Soft tissue	G401	7.9
Soft tissue	G402	7.7
Soft tissue	GCT	8.3
Soft tissue	HS729	8
Soft tissue	HT1080	7.9
Soft tissue	KYM1	7.7
Soft tissue	MESSA	7.5
Soft tissue	RD	7.9
Soft tissue	RH30	7.4
Soft tissue	RH41	8
Soft tissue	RKN	8.1
Soft tissue	S117	7.2
Soft tissue	SJRH30	8.2
Soft tissue	SKLMS1	8.3
Soft tissue	SKUT1	8.3
Soft tissue	TE125T	7.4
Soft tissue	TE159T	7.7
Soft tissue	TE441T	8
Soft tissue	TE617T	7.6
Stomach	2313287	7.7
Stomach	AGS	7.8
Stomach	AZ521	7.9
Stomach	ECC10	7.8
Stomach	ECC12	8.5
Stomach	FU97	7.3
Stomach	GCIY	7.8
Stomach	GSS	7.6
Stomach	GSU	7.5
Stomach	HGC27	7.9
Stomach	HS746T	7.5
Stomach	HUG1N	7.8
Stomach	IM95	7.4
Stomach	KATOIII	7.3
Stomach	KE39	7.6
Stomach	LMSU	7.9
Stomach	MKN1	7.8
Stomach	MKN45	8.1
Stomach	MKN74	7.8
Stomach	MKN7	7.9
Stomach	NCCSTCK140	6.8
Stomach	NCIN87	8.1
Stomach	NUGC2	7.7
Stomach	NUGC3	7.5
Stomach	NUGC4	7.7
Stomach	OCUM1	7.4
Stomach	RERFGC1B	8.7
Stomach	SH10TC	7.7
Stomach	SNU16	6.9
Stomach	SNU1	8.1
Stomach	SNU216	7.7
Stomach	SNU520	7.2
Stomach	SNU5	7.4
Stomach	SNU601	7.4
Stomach	SNU620	7.4
Stomach	SNU668	7.6
Stomach	SNU719	7.4
Stomach	TGBC11TKB	8.2
Thyroid	8305C	7
Thyroid	8505C	7.7
Thyroid	BCPAP	8
Thyroid	BHT101	7.7
Thyroid	CAL62	8.2
Thyroid	CGTHW1	7.8
Thyroid	FTC133	7.5
Thyroid	FTC238	8.1
Thyroid	ML1	8
Thyroid	SW579	7.5
Thyroid	TT2609C02	7.6
Thyroid	TT	8.3
Upper aerodigestive tract	BHY	7.5
Upper aerodigestive tract	BICR16	7.8
Upper aerodigestive tract	BICR18	7.7
Upper aerodigestive tract	BICR22	7.1
Upper aerodigestive tract	BICR31	7.6
Upper aerodigestive tract	BICR56	7.7
Upper aerodigestive tract	BICR6	7.7
Upper aerodigestive tract	CAL27	7.8
Upper aerodigestive tract	CAL33	7.3
Upper aerodigestive tract	DETROIT562	7.3
Upper aerodigestive tract	FADU	8.1
Upper aerodigestive tract	HS840T	7.5
Upper aerodigestive tract	HSC2	7.9
Upper aerodigestive tract	HSC3	7.6
Upper aerodigestive tract	HSC4	7.4
Upper aerodigestive tract	PECAPJ15	7.8
Upper aerodigestive tract	PECAPJ34CLONEC12	7.4
Upper aerodigestive tract	PECAPJ41CLONED2	7.9
Upper aerodigestive tract	PECAPJ49	7.9
Upper aerodigestive tract	SCC15	8
Upper aerodigestive tract	SCC25	7.3
Upper aerodigestive tract	SCC4	7.3
Upper aerodigestive tract	SCC9	8.5
Upper aerodigestive tract	SNU1076	7.8
Upper aerodigestive tract	SNU1214	7.6
Upper aerodigestive tract	SNU46	8.3
Upper aerodigestive tract	SNU899	7.5
Upper aerodigestive tract	YD10B	8.8
Upper aerodigestive tract	YD38	8
Upper aerodigestive tract	YD8	8.2
Urinary tract	5637	7.4
Urinary tract	639V	7.9
Urinary tract	647V	7.4
Urinary tract	BC3C	7.6
Urinary tract	BFTC905	7.1
Urinary tract	CAL29	7.4
Urinary tract	HS172T	7.4
Urinary tract	HT1197	7.1
Urinary tract	HT1376	7.8
Urinary tract	J82	7.4
Urinary tract	JMSU1	8.2
Urinary tract	KMBC2	7.4
Urinary tract	KU1919	7.8
Urinary tract	RT11284	7.8
Urinary tract	RT112	7.7
Urinary tract	RT4	7.8
Urinary tract	SCABER	7.6
Urinary tract	SW1710	7.9
Urinary tract	SW780	8.8
Urinary tract	T24	8
Urinary tract	TCCSUP	7.3
Urinary tract	UMUC1	7.4
Urinary tract	UMUC3	8.5
Urinary tract	VMCUB1	7.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	16
Adrenal gland	24.6
Appendix	21.2
Bone marrow	14.2
Breast	31.7
Cerebral cortex	38.1
Cervix, uterine	30.7
Colon	19
Duodenum	16
Endometrium	45.2
Epididymis	49.7
Esophagus	17
Fallopian tube	41
Gallbladder	25.9
Heart muscle	11.5
Kidney	22.3
Liver	7.2
Lung	29.8
Lymph node	24.1
Ovary	40.3
Pancreas	4.3
Parathyroid gland	43.8
Placenta	35.5
Prostate	37.5
Rectum	27.9
Salivary gland	8.6
Seminal vesicle	33.3
Skeletal muscle	8
Skin	28
Small intestine	16.9
Smooth muscle	37.5
Spleen	26.2
Stomach	16.9
Testis	147.8
Thyroid gland	38.1
Tonsil	21.7
Urinary bladder	22.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
19787264	Overexpression	Colorectal Carcinoma	BRD8 protein expression level is several-fold higher in human metastatic colorectal cancer cell lines (DLD-1, HCA-7 and HCT-116) than in other cell lines tested.

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.537	1.46e-31	46.3	46.8	6.9	Loss
BRCA	Breast invasive carcinoma	1075	0.585	7.04e-100	22	57.9	20.2	Neutral
CESC	Cervical and endocervical cancers	292	0.581	8.47e-28	21.9	67.5	10.6	Neutral
COAD	Colon adenocarcinoma	449	0.415	4.31e-20	20.5	71.7	7.8	Neutral
ESCA	Esophageal carcinoma	183	0.463	3.91e-11	50.3	43.7	6	Loss
GBM	Glioblastoma multiforme	147	0.428	6.33e-08	12.2	80.3	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.569	2.15e-45	38.3	54.7	7	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.444	7.81e-27	0.8	39	60.2	Gain
KIRP	Kidney renal papillary cell carcinoma	288	0.433	1.32e-14	4.2	83.3	12.5	Neutral
LAML	Acute Myeloid Leukemia	166	0.442	2.49e-09	9	91	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.318	1.77e-13	9	89.3	1.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.461	1.52e-20	11	56.6	32.4	Neutral
LUAD	Lung adenocarcinoma	512	0.514	6.63e-36	37.7	44.7	17.6	Loss
LUSC	Lung squamous cell carcinoma	498	0.464	5.23e-28	74.5	21.1	4.4	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.551	3.53e-25	42.3	42.7	15	Loss
PAAD	Pancreatic adenocarcinoma	177	0.603	7.08e-19	10.7	78.5	10.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.421	2.44e-08	7.4	87.7	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.405	7.44e-21	5.9	90	4.1	Neutral
READ	Rectum adenocarcinoma	164	0.496	1.46e-11	29.3	59.8	11	Neutral
SARC	Sarcoma	255	0.47	2.11e-15	14.5	58.8	26.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.529	6.75e-28	33.2	55.6	11.2	Neutral
STAD	Stomach adenocarcinoma	413	0.36	4.5e-14	32	62.2	5.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.297	0.000221	65.3	32	2.7	Loss
THCA	Thyroid carcinoma	497	0.194	1.28e-05	0	96.2	3.8	Neutral
THYM	Thymoma	119	0.02	0.829	0.8	91.6	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.226	1.14e-07	15.8	79.7	4.5	Neutral

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.382	1.41e-16	17	408	-0.105	0.000466	NS/NA
BRCA	Breast invasive carcinoma	-0.344	0	83	785	-0.014	0.0853	NS/NA
CESC	Cervical and endocervical cancers	-0.342	8.31e-10	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.217	0.000106	19	297	0.015	0.00493	NS/NA
ESCA	Esophageal carcinoma	-0.269	0.000155	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.313	0.0113	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	0	0.999	20	522	0.032	0.00823	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.024	0.656	24	319	0.006	0.000274	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.067	0.252	23	275	0.137	9.63e-24	NS/NA
LAML	Acute Myeloid Leukemia	0.152	0.0476	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.243	1.55e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.331	6.92e-12	41	373	-0.168	4.97e-18	NS/NA
LUAD	Lung adenocarcinoma	-0.31	5.3e-12	21	456	-0.043	0.00377	NS/NA
LUSC	Lung squamous cell carcinoma	-0.096	0.0616	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.5	0.178	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.139	0.06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.259	0.000368	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.15	0.00053	35	498	-0.025	0.00519	NS/NA
READ	Rectum adenocarcinoma	-0.275	0.00559	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.448	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.294	9.11e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.255	7.06e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.264	0.000884	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.178	2.42e-05	50	509	-0.043	0.112	NS/NA
THYM	Thymoma	0.315	0.000446	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.207	7.39e-06	34	431	-0.023	0.0132	NS/NA

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	3	High
Cerebral cortex	1	Low
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	1	Low
Lung	3	High
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	1	Low
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.274	NS	24476821
BRCA	Breast invasive carcinoma	521	2.54e-24	Significant	23000897
COAD	Colon adenocarcinoma	149	0.191	NS	22810696
GBM	Glioblastoma multiforme	157	1.86e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.05e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.212	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.26e-22	Significant	26824661
LUAD	Lung adenocarcinoma	230	9.55e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.51e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0017	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0147	Significant	26544944
READ	Rectum adenocarcinoma	67	0.273	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.222	NS	26091043
STAD	Stomach adenocarcinoma	277	1.97e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.00121	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00576	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.893	0.59	NS
BRCA	Breast invasive carcinoma	1079	1.19	0.448	NS
CESC	Cervical and endocervical cancers	291	1.037	0.915	NS
COAD	Colon adenocarcinoma	439	0.765	0.322	NS
ESCA	Esophageal carcinoma	184	1.212	0.567	NS
GBM	Glioblastoma multiforme	158	0.783	0.327	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.791	0.223	NS
KIRC	Kidney renal clear cell carcinoma	531	1.302	0.216	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.057	0.89	NS
LAML	Acute Myeloid Leukemia	149	0.723	0.269	NS
LGG	Brain Lower Grade Glioma	511	0.598	0.0318	Longer
LIHC	Liver hepatocellular carcinoma	365	1.549	0.0717	NS
LUAD	Lung adenocarcinoma	502	0.853	0.478	NS
LUSC	Lung squamous cell carcinoma	494	1.201	0.344	NS
OV	Ovarian serous cystadenocarcinoma	303	0.964	0.866	NS
PAAD	Pancreatic adenocarcinoma	177	0.758	0.384	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.441	0.452	NS
PRAD	Prostate adenocarcinoma	497	4.086	0.195	NS
READ	Rectum adenocarcinoma	159	0.345	0.0977	NS
SARC	Sarcoma	259	0.749	0.31	NS
SKCM	Skin Cutaneous Melanoma	459	0.908	0.623	NS
STAD	Stomach adenocarcinoma	388	0.889	0.603	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.614	0.5	NS
THYM	Thymoma	119	0.526	0.531	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.078	0.794	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.193	9.37e-05	Lower
BRCA	Breast invasive carcinoma	1071	0.014	0.647	NS
CESC	Cervical and endocervical cancers	167	0.167	0.0305	Higher
COAD	Colon adenocarcinoma	445	-0.027	0.571	NS
ESCA	Esophageal carcinoma	162	0.141	0.0731	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.02	0.669	NS
KIRC	Kidney renal clear cell carcinoma	531	0.054	0.215	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.121	0.051	NS
LIHC	Liver hepatocellular carcinoma	347	0.08	0.139	NS
LUAD	Lung adenocarcinoma	507	-0.034	0.449	NS
LUSC	Lung squamous cell carcinoma	497	0.019	0.677	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.059	0.31	NS
PAAD	Pancreatic adenocarcinoma	176	-0.128	0.0895	NS
READ	Rectum adenocarcinoma	156	0.075	0.351	NS
SKCM	Skin Cutaneous Melanoma	410	-0.059	0.237	NS
STAD	Stomach adenocarcinoma	392	0.047	0.354	NS
TGCT	Testicular Germ Cell Tumors	81	0.184	0.101	NS
THCA	Thyroid carcinoma	499	0.027	0.552	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.033	0.459	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.035	0.565	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.199	7.71e-06	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.018	0.673	NS
LGG	Brain Lower Grade Glioma	514	-0.1	0.0232	Lower
LIHC	Liver hepatocellular carcinoma	366	0.127	0.0151	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.05	0.393	NS
PAAD	Pancreatic adenocarcinoma	176	0.023	0.761	NS
STAD	Stomach adenocarcinoma	406	0.024	0.634	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.177	3.98e-05	Higher

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for BRD8.

Summary
Symbol	BRD8
Name	bromodomain containing 8
Aliases	skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120; Skele ......
Location	5q31.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for BRD8.